WO2008105514A1 - 多分岐鎖ポリオキシアルキレン誘導体 - Google Patents

多分岐鎖ポリオキシアルキレン誘導体 Download PDF

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Publication number
WO2008105514A1
WO2008105514A1 PCT/JP2008/053568 JP2008053568W WO2008105514A1 WO 2008105514 A1 WO2008105514 A1 WO 2008105514A1 JP 2008053568 W JP2008053568 W JP 2008053568W WO 2008105514 A1 WO2008105514 A1 WO 2008105514A1
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Prior art keywords
biological substance
polyoxyalkylene derivative
derivative
multibranched
modify
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PCT/JP2008/053568
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English (en)
French (fr)
Inventor
Kenji Sakanoue
Hiroki Yoshioka
Tomohiro SHIROSAKI
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Nof Corporation
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Publication date
Application filed by Nof Corporation filed Critical Nof Corporation
Priority to US12/529,043 priority Critical patent/US8071712B2/en
Priority to CN200880006322XA priority patent/CN101622295B/zh
Priority to EP08721017.5A priority patent/EP2116561B1/en
Priority to DK08721017.5T priority patent/DK2116561T3/en
Publication of WO2008105514A1 publication Critical patent/WO2008105514A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/327—Polymers modified by chemical after-treatment with inorganic compounds containing phosphorus
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/3311—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group
    • C08G65/3314—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic
    • C08G65/3315—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic
    • C08G65/3317—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic phenolic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/3311—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group
    • C08G65/3318—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
    • C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33365—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing cyano group
    • C08G65/33368—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing cyano group acyclic
    • C08G65/33372—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing cyano group acyclic acrylonitrile
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
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  • Inorganic Chemistry (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明の目的は、新規多分岐鎖ポリオキシアルキレン誘導体、およびその製造中間体の提供である。詳細には、該多分岐鎖ポリオキシアルキレン誘導体で修飾された生体関連物質が高い活性率を保持出来、かつ該修飾体の製造が容易な多分岐鎖ポリオキシアルキレン誘導体、その中間体および生体関連物質が結合した該多分岐鎖ポリオキシアルキレン誘導体を提供することにある。生体関連物質と反応可能な官能基を有するポリオキシアルキレン誘導体（１）、当該化合物との反応により修飾された生体関連物質、および当該化合物の中間体であるポリオキシアルキレン誘導体（Ａ）を提供する。（式（１）または（Ａ）中、Ａ１ＯおよびＡ２Ｏは、独立して、炭素数２～４のオキシアルキレン基を示し、ｍは２０～５００、ｎは１５～７００を示し、Ｒは、水素原子または炭素数１～２０個の炭化水素基を示し、Ｘは生体関連物質と反応可能な官能基を示し、Ｘ１は保護されていてもよい水酸基を示す。）
PCT/JP2008/053568 2007-02-28 2008-02-28 多分岐鎖ポリオキシアルキレン誘導体 WO2008105514A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/529,043 US8071712B2 (en) 2007-02-28 2008-02-28 Multibranched polyoxyalkylene derivative
CN200880006322XA CN101622295B (zh) 2007-02-28 2008-02-28 多支链聚氧化亚烷基衍生物
EP08721017.5A EP2116561B1 (en) 2007-02-28 2008-02-28 Multibranched polyoxyalkylene derivative
DK08721017.5T DK2116561T3 (en) 2007-02-28 2008-02-28 branched polyoxyalkylenic compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-050782 2007-02-28
JP2007050782 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105514A1 true WO2008105514A1 (ja) 2008-09-04

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PCT/JP2008/053568 WO2008105514A1 (ja) 2007-02-28 2008-02-28 多分岐鎖ポリオキシアルキレン誘導体

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Country Link
US (1) US8071712B2 (ja)
EP (1) EP2116561B1 (ja)
JP (1) JP5515224B2 (ja)
CN (1) CN101622295B (ja)
DK (1) DK2116561T3 (ja)
WO (1) WO2008105514A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010155917A (ja) * 2008-12-26 2010-07-15 Nof Corp ポリオキシアルキレンポリグリセリルエーテル誘導体の製造方法
WO2011093508A1 (ja) * 2010-02-01 2011-08-04 日油株式会社 ポリアルキレングリコール誘導体およびこれを配合してなる化粧料
JP2011157466A (ja) * 2010-02-01 2011-08-18 Nof Corp ポリアルキレングリコール誘導体
KR20120014167A (ko) * 2009-05-15 2012-02-16 솔베이 솔렉시스 에스.피.에이. 폴리올 ｐｆｐｅ 유도체의 정제 방법
KR20120023747A (ko) * 2009-05-15 2012-03-13 솔베이 솔렉시스 에스.피.에이. 폴리올 ｐｆｐｅ 유도체의 정제 방법
WO2012133490A1 (ja) * 2011-03-30 2012-10-04 日油株式会社 末端に複数の水酸基を有するポリオキシエチレン誘導体
WO2013147015A1 (ja) * 2012-03-30 2013-10-03 日油株式会社 マルチアーム型ポリエチレングリコール誘導体、その中間体及び製造方法

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JP5589503B2 (ja) 2009-03-31 2014-09-17 日油株式会社 多分岐鎖ポリオキシアルキレン化合物、その製造方法および中間体
WO2013059323A1 (en) * 2011-10-18 2013-04-25 Prolynx Llc Peg conjugates of exenatide
JP6028649B2 (ja) * 2013-03-26 2016-11-16 日油株式会社 生分解性ポリオキシエチレン誘導体の製造方法
KR102247701B1 (ko) * 2016-02-26 2021-05-03 한미정밀화학주식회사 폴리에틸렌글리콜 디알데히드 유도체의 제조방법
JP6240709B2 (ja) * 2016-05-13 2017-11-29 第一工業製薬株式会社 加硫ゴム成形用離型剤
CN109134282B (zh) * 2017-06-28 2021-03-16 北京键凯科技股份有限公司 一种树状多缩乙二醇衍生物及其制备方法和应用
MX2020004332A (es) * 2017-11-06 2020-08-03 Hanmi Fine Chemical Co Ltd Derivado de polietilenglicol y metodo de preparacion del mismo.
WO2019181081A1 (ja) * 2018-03-19 2019-09-26 竹本油脂株式会社 ブリーディング抑制剤

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JP2007050782A (ja) 2005-08-18 2007-03-01 Toyota Motor Corp 車両用衝撃吸収構造
JP2007508427A (ja) 2003-10-09 2007-04-05 アンブレツクス・インコーポレイテツド アジドまたはアセチレン末端水溶性ポリマー

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JPS6142558B2 (ja) 1979-04-05 1986-09-22 Mihama Hisaharu
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JP2007503514A (ja) * 2003-08-26 2007-02-22 スミスクライン・ビーチャム・コーポレイション グリセロールおよびポリエチレングリコールのヘテロ官能性コポリマー、そのコンジュゲートおよび組成物
JP2007508427A (ja) 2003-10-09 2007-04-05 アンブレツクス・インコーポレイテツド アジドまたはアセチレン末端水溶性ポリマー
JP2007050782A (ja) 2005-08-18 2007-03-01 Toyota Motor Corp 車両用衝撃吸収構造

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See also references of EP2116561A4 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010155917A (ja) * 2008-12-26 2010-07-15 Nof Corp ポリオキシアルキレンポリグリセリルエーテル誘導体の製造方法
KR20120014167A (ko) * 2009-05-15 2012-02-16 솔베이 솔렉시스 에스.피.에이. 폴리올 ｐｆｐｅ 유도체의 정제 방법
KR20120023747A (ko) * 2009-05-15 2012-03-13 솔베이 솔렉시스 에스.피.에이. 폴리올 ｐｆｐｅ 유도체의 정제 방법
JP2012526873A (ja) * 2009-05-15 2012-11-01 ソルヴェイ・スペシャルティ・ポリマーズ・イタリー・エッセ・ピ・ア ポリオールｐｆｐｅ誘導体の精製方法
JP2012526875A (ja) * 2009-05-15 2012-11-01 ソルヴェイ・スペシャルティ・ポリマーズ・イタリー・エッセ・ピ・ア ポリオールｐｆｐｅ誘導体の精製方法
KR101699565B1 (ko) 2009-05-15 2017-01-24 솔베이 스페셜티 폴리머스 이태리 에스.피.에이. 폴리올 ｐｆｐｅ 유도체의 정제 방법
KR101694567B1 (ko) 2009-05-15 2017-01-09 솔베이 스페셜티 폴리머스 이태리 에스.피.에이. 폴리올 ｐｆｐｅ 유도체의 정제 방법
WO2011093508A1 (ja) * 2010-02-01 2011-08-04 日油株式会社 ポリアルキレングリコール誘導体およびこれを配合してなる化粧料
JP2011157466A (ja) * 2010-02-01 2011-08-18 Nof Corp ポリアルキレングリコール誘導体
US8952125B2 (en) 2011-03-30 2015-02-10 Nof Corporation Polyoxyethylene derivative having plural hydroxyl groups at terminal end thereof
WO2012133490A1 (ja) * 2011-03-30 2012-10-04 日油株式会社 末端に複数の水酸基を有するポリオキシエチレン誘導体
WO2013147015A1 (ja) * 2012-03-30 2013-10-03 日油株式会社 マルチアーム型ポリエチレングリコール誘導体、その中間体及び製造方法
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KR20140148403A (ko) * 2012-03-30 2014-12-31 니치유 가부시키가이샤 다중-아암 폴리에틸렌 글리콜 유도체, 그 유도체의 중간체, 및 그 유도체의 제조방법
JP2013227543A (ja) * 2012-03-30 2013-11-07 Nof Corp マルチアーム型ポリエチレングリコール誘導体、その中間体及び製造方法
US9908971B2 (en) 2012-03-30 2018-03-06 Nof Corporation Multi-arm polyethylene glycol derivative, intermediate thereof, and method for producing same
KR101918339B1 (ko) * 2012-03-30 2018-11-13 니치유 가부시키가이샤 다중-아암 폴리에틸렌 글리콜 유도체, 그 유도체의 중간체, 및 그 유도체의 제조방법

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US20100029899A1 (en) 2010-02-04
CN101622295A (zh) 2010-01-06
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EP2116561A4 (en) 2015-01-07
EP2116561A1 (en) 2009-11-11

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