WO2008105507A1 - 脊髄損傷治療薬剤 - Google Patents
脊髄損傷治療薬剤 Download PDFInfo
- Publication number
- WO2008105507A1 WO2008105507A1 PCT/JP2008/053557 JP2008053557W WO2008105507A1 WO 2008105507 A1 WO2008105507 A1 WO 2008105507A1 JP 2008053557 W JP2008053557 W JP 2008053557W WO 2008105507 A1 WO2008105507 A1 WO 2008105507A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- therapeutic agent
- spinal cord
- cord injury
- demyelinating disease
- disclosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020157033326A KR20150138413A (ko) | 2007-02-28 | 2008-02-28 | 척수 손상 치료제 |
JP2009501304A JP5419045B2 (ja) | 2007-02-28 | 2008-02-28 | 脊髄損傷治療薬剤 |
CA2675953A CA2675953C (en) | 2007-02-28 | 2008-02-28 | Therapeutic agent for spinal cord injuries |
ES08721006T ES2412388T3 (es) | 2007-02-28 | 2008-02-28 | Administración intratecal de FCH después de una lesión en la médula espinal |
DK08721006.8T DK2116255T3 (da) | 2007-02-28 | 2008-02-28 | Intratekal indgivelse af hgf efter rygmarvsskade |
CN200880004651.0A CN101610783B (zh) | 2007-02-28 | 2008-02-28 | 脊髓损伤治疗剂 |
EP08721006.8A EP2116255B1 (en) | 2007-02-28 | 2008-02-28 | Intrathecal administration of hgf after spinal cord injury |
KR1020097019957A KR101670677B1 (ko) | 2007-02-28 | 2008-02-28 | 척수 손상 치료제 |
US12/548,881 US8518880B2 (en) | 2007-02-28 | 2009-08-27 | Therapeutic agent for spinal cord injuries |
HK10101945.2A HK1134445A1 (en) | 2007-02-28 | 2010-02-24 | Intrathecal administration of hgf after spinal cord injury |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2007/053804 WO2008105088A1 (ja) | 2007-02-28 | 2007-02-28 | 脊髄損傷治療薬剤 |
JPPCT/JP2007/053804 | 2007-02-28 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/053804 Continuation-In-Part WO2008105088A1 (ja) | 2007-02-28 | 2007-02-28 | 脊髄損傷治療薬剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/548,881 Continuation US8518880B2 (en) | 2007-02-28 | 2009-08-27 | Therapeutic agent for spinal cord injuries |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008105507A1 true WO2008105507A1 (ja) | 2008-09-04 |
Family
ID=39720932
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/053804 WO2008105088A1 (ja) | 2007-02-28 | 2007-02-28 | 脊髄損傷治療薬剤 |
PCT/JP2008/053557 WO2008105507A1 (ja) | 2007-02-28 | 2008-02-28 | 脊髄損傷治療薬剤 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/053804 WO2008105088A1 (ja) | 2007-02-28 | 2007-02-28 | 脊髄損傷治療薬剤 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8518880B2 (ja) |
EP (1) | EP2116255B1 (ja) |
KR (2) | KR20150138413A (ja) |
CN (2) | CN101610783B (ja) |
CA (1) | CA2675953C (ja) |
DK (1) | DK2116255T3 (ja) |
ES (1) | ES2412388T3 (ja) |
HK (1) | HK1134445A1 (ja) |
PT (1) | PT2116255E (ja) |
WO (2) | WO2008105088A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010041716A1 (ja) * | 2008-10-10 | 2010-04-15 | クリングルファーマ株式会社 | 腱骨移行部組織または靭帯骨移行部組織の再生促進剤 |
JP2014517695A (ja) * | 2011-05-23 | 2014-07-24 | アジュ ユニヴァーシティー インダストリー−アカデミック コーオペレイション ファウンデーション | 肝細胞増殖因子の遺伝子と、塩基性ヘリックスループヘリックスモチーフを有する神経原性転写因子の遺伝子とを導入した成体幹細胞株、及びその使用 |
US10213485B2 (en) | 2014-09-10 | 2019-02-26 | Kringle Pharma Inc. | HGF preparation suitable for treatment of neurological disorders |
JP2022522941A (ja) * | 2019-01-07 | 2022-04-21 | ベイジン・ノースランド・バイオテック・カンパニー・リミテッド | ヒト肝細胞増殖因子変異体およびその使用 |
WO2023171808A1 (ja) * | 2022-03-11 | 2023-09-14 | 慶應義塾 | 脊髄損傷治療剤 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012018069A1 (ja) * | 2010-08-06 | 2012-02-09 | 大日本住友製薬株式会社 | 脊髄損傷治療用製剤 |
US10716564B2 (en) | 2017-02-17 | 2020-07-21 | Ethicon Llc | Stapling adjunct attachment |
US10478280B2 (en) * | 2017-02-17 | 2019-11-19 | Ethicon Llc | Methods and devices for delivering and securing adjunct materials to a treatment site |
CN113433324B (zh) * | 2021-05-28 | 2022-11-18 | 南通大学 | Nck1蛋白作为标志物在诊断脊髓损伤中的应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6128521A (ja) | 1984-07-06 | 1986-02-08 | Wako Pure Chem Ind Ltd | 新規重合体及びその製造法 |
JPH05111382A (ja) | 1991-10-22 | 1993-05-07 | Saito Signal Kenkyusho:Kk | ヒト好酸球細胞株 |
WO2003045439A1 (fr) | 2001-11-28 | 2003-06-05 | Anges Mg, Inc. | Preparations medicinales contenant du materiel genetique destinees au traitement de maladies neurodegeneratives |
WO2005100577A1 (en) | 2004-04-14 | 2005-10-27 | Agency For Science, Technology And Research | Method for gene delivery to neuronal cells |
WO2006077675A1 (ja) * | 2005-01-24 | 2006-07-27 | Kringle Pharma Inc. | 移植臓器の線維化抑制剤 |
WO2007032396A1 (ja) * | 2005-09-16 | 2007-03-22 | Keio University | 脊髄損傷治療剤 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143714A (en) * | 1994-10-24 | 2000-11-07 | Regeneron Pharmaceuticals, Inc. | Methods of using hepatocyte growth factor to promote survival, growth and differentiation of motor neurons |
US7033608B1 (en) * | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
WO2004021992A2 (en) * | 2002-09-06 | 2004-03-18 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
CN1250287C (zh) * | 2002-11-20 | 2006-04-12 | 中国人民解放军军事医学科学院放射医学研究所 | 一种重组腺病毒在脑缺血、创伤修复和组织粘连治疗中的应用 |
JP2005035945A (ja) * | 2003-07-16 | 2005-02-10 | Cardio Corp | 組織再生複合療法 |
JP2007238487A (ja) | 2006-03-07 | 2007-09-20 | Osaka Univ | 脊髄損傷に対する嗅粘膜移植にhgfを用いた神経機能再建法 |
-
2007
- 2007-02-28 WO PCT/JP2007/053804 patent/WO2008105088A1/ja active Application Filing
-
2008
- 2008-02-28 CN CN200880004651.0A patent/CN101610783B/zh active Active
- 2008-02-28 KR KR1020157033326A patent/KR20150138413A/ko not_active Application Discontinuation
- 2008-02-28 DK DK08721006.8T patent/DK2116255T3/da active
- 2008-02-28 PT PT87210068T patent/PT2116255E/pt unknown
- 2008-02-28 CA CA2675953A patent/CA2675953C/en active Active
- 2008-02-28 ES ES08721006T patent/ES2412388T3/es active Active
- 2008-02-28 WO PCT/JP2008/053557 patent/WO2008105507A1/ja active Application Filing
- 2008-02-28 KR KR1020097019957A patent/KR101670677B1/ko active IP Right Grant
- 2008-02-28 EP EP08721006.8A patent/EP2116255B1/en active Active
- 2008-02-28 CN CN201510716455.8A patent/CN105311620A/zh active Pending
-
2009
- 2009-08-27 US US12/548,881 patent/US8518880B2/en active Active
-
2010
- 2010-02-24 HK HK10101945.2A patent/HK1134445A1/xx unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6128521A (ja) | 1984-07-06 | 1986-02-08 | Wako Pure Chem Ind Ltd | 新規重合体及びその製造法 |
JPH05111382A (ja) | 1991-10-22 | 1993-05-07 | Saito Signal Kenkyusho:Kk | ヒト好酸球細胞株 |
WO2003045439A1 (fr) | 2001-11-28 | 2003-06-05 | Anges Mg, Inc. | Preparations medicinales contenant du materiel genetique destinees au traitement de maladies neurodegeneratives |
WO2005100577A1 (en) | 2004-04-14 | 2005-10-27 | Agency For Science, Technology And Research | Method for gene delivery to neuronal cells |
WO2006077675A1 (ja) * | 2005-01-24 | 2006-07-27 | Kringle Pharma Inc. | 移植臓器の線維化抑制剤 |
WO2007032396A1 (ja) * | 2005-09-16 | 2007-03-22 | Keio University | 脊髄損傷治療剤 |
Non-Patent Citations (12)
Title |
---|
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 122, 1984, pages 1450 - 1459 |
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967 |
CLIN. CHIM ACTA., vol. 327, 2003, pages 1 - 23 |
IWANAMI A.: "Sekizui Sonsho ni Taisuru Hepatocyte Growth Factor (HGF) no Yukosei no Kento", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 79, no. 8, 2005, pages S764, XP003010152 * |
KITAMURA H.: "Sekizui Sonsho ni Taisuru Hepatocyte Growth Factor no Yukosei no Kento", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 80, no. 8, 2006, pages S884, XP003023237 * |
KITAMURA K.: "Sekizui Sonsho ni Taisuru Hepatocyte Growth Factor no Yokusei no Kento", JOURNAL OF THE JAPAN SPINE RESEARCH SOCIETY, vol. 17, no. 1, 2006, pages 557, XP003023238 * |
M. BODANSZKY; M.A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS |
NAT. NEUROSCI., vol. 2, 1999, pages 213 - 217 |
NATURE, vol. 342, 1989, pages 440 - 443 |
SCHROEDER; LUEBKE: "The Peptide", 1965, ACADEMIC PRESS |
See also references of EP2116255A4 |
THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 79, no. 8, 25 August 2005 (2005-08-25), pages S764 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010041716A1 (ja) * | 2008-10-10 | 2010-04-15 | クリングルファーマ株式会社 | 腱骨移行部組織または靭帯骨移行部組織の再生促進剤 |
EP2351574A4 (en) * | 2008-10-10 | 2012-03-28 | Kringle Pharma Inc | PROMOTER TO REGENERATE TEN-BONE JOINTS OR BAND BONE JOINTS |
US8927493B2 (en) | 2008-10-10 | 2015-01-06 | Kringle Pharma, Inc. | Promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue |
JP2014517695A (ja) * | 2011-05-23 | 2014-07-24 | アジュ ユニヴァーシティー インダストリー−アカデミック コーオペレイション ファウンデーション | 肝細胞増殖因子の遺伝子と、塩基性ヘリックスループヘリックスモチーフを有する神経原性転写因子の遺伝子とを導入した成体幹細胞株、及びその使用 |
US10213485B2 (en) | 2014-09-10 | 2019-02-26 | Kringle Pharma Inc. | HGF preparation suitable for treatment of neurological disorders |
US10702582B2 (en) | 2014-09-10 | 2020-07-07 | Kringle Pharma Inc. | HGF preparation suitable for treatment of neurological disorders |
JP2022522941A (ja) * | 2019-01-07 | 2022-04-21 | ベイジン・ノースランド・バイオテック・カンパニー・リミテッド | ヒト肝細胞増殖因子変異体およびその使用 |
JP7246494B2 (ja) | 2019-01-07 | 2023-03-27 | ベイジン・ノースランド・バイオテック・カンパニー・リミテッド | ヒト肝細胞増殖因子変異体およびその使用 |
WO2023171808A1 (ja) * | 2022-03-11 | 2023-09-14 | 慶應義塾 | 脊髄損傷治療剤 |
Also Published As
Publication number | Publication date |
---|---|
CN105311620A (zh) | 2016-02-10 |
US20100081617A1 (en) | 2010-04-01 |
CN101610783B (zh) | 2016-11-16 |
CN101610783A (zh) | 2009-12-23 |
CA2675953C (en) | 2016-05-10 |
KR20150138413A (ko) | 2015-12-09 |
CA2675953A1 (en) | 2008-09-04 |
HK1134445A1 (en) | 2010-04-30 |
ES2412388T3 (es) | 2013-07-11 |
WO2008105088A1 (ja) | 2008-09-04 |
KR101670677B1 (ko) | 2016-11-01 |
EP2116255B1 (en) | 2013-04-10 |
PT2116255E (pt) | 2013-06-21 |
US20120021040A9 (en) | 2012-01-26 |
EP2116255A1 (en) | 2009-11-11 |
EP2116255A4 (en) | 2011-05-04 |
US8518880B2 (en) | 2013-08-27 |
DK2116255T3 (da) | 2013-05-13 |
KR20090118078A (ko) | 2009-11-17 |
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