WO2008099800A1 - 放射性画像診断剤の製造方法 - Google Patents

放射性画像診断剤の製造方法 Download PDF

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Publication number
WO2008099800A1
WO2008099800A1 PCT/JP2008/052231 JP2008052231W WO2008099800A1 WO 2008099800 A1 WO2008099800 A1 WO 2008099800A1 JP 2008052231 W JP2008052231 W JP 2008052231W WO 2008099800 A1 WO2008099800 A1 WO 2008099800A1
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Prior art keywords
solution
radioactive
labeled
organic compound
imaging agent
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PCT/JP2008/052231
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English (en)
French (fr)
Inventor
Daisaku Nakamura
Soichi Nakamura
Masahito Toyama
Akio Hayashi
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Nihon Medi-Physics Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi-Physics Co., Ltd. filed Critical Nihon Medi-Physics Co., Ltd.
Priority to JP2008558082A priority Critical patent/JP5258583B2/ja
Priority to CN200880008655.6A priority patent/CN101636183B/zh
Priority to CA2678020A priority patent/CA2678020C/en
Priority to KR1020097017131A priority patent/KR101485445B1/ko
Priority to EP08711095.3A priority patent/EP2119458B9/en
Priority to US12/526,667 priority patent/US8343459B2/en
Priority to ES08711095T priority patent/ES2421886T3/es
Publication of WO2008099800A1 publication Critical patent/WO2008099800A1/ja
Priority to HK10104126.7A priority patent/HK1138504A1/xx
Priority to US13/565,204 priority patent/US8658132B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/04—Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

【課題】放射性ハロゲン標識アミノ酸化合物を有効成分とする放射性画像診断剤において、該有効成分の放射線分解を抑制し、より安定性を高め得る組成を有したものの製造方法を提供する。 【解決手段】放射性ハロゲン標識アミノ酸化合物を含有した溶液を調製する放射性フッ素標識有機化合物溶液調製工程と、前記放射性フッ素標識有機化合物を含有した溶液を希釈して放射能濃度を調整する希釈工程とを含む放射性画像診断剤の製造方法において、前記放射性フッ素標識有機化合物溶液調製工程後、前記希釈工程前に、前記放射性フッ素標識有機化合物を含有した溶液に酸を加える酸添加工程を含み、前記酸添加工程において添加する酸の量が、希釈工程後の液のｐHを２．０から５．９とするのに十分な量、例えば、希釈工程後の液１Ｌに対して０．４０～２．８ｍｍｏｌ相当であることを特徴とする方法を用いる。
PCT/JP2008/052231 2007-02-13 2008-02-12 放射性画像診断剤の製造方法 WO2008099800A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2008558082A JP5258583B2 (ja) 2007-02-13 2008-02-12 放射性画像診断剤の製造方法
CN200880008655.6A CN101636183B (zh) 2007-02-13 2008-02-12 放射性诊断显像剂的制备方法
CA2678020A CA2678020C (en) 2007-02-13 2008-02-12 Method for production of radiation diagnostic imaging agent
KR1020097017131A KR101485445B1 (ko) 2007-02-13 2008-02-12 방사성 화상진단제의 제조 방법
EP08711095.3A EP2119458B9 (en) 2007-02-13 2008-02-12 Method for production of radiation diagnostic imaging agent
US12/526,667 US8343459B2 (en) 2007-02-13 2008-02-12 Method for production of radiation diagnostic imaging agent
ES08711095T ES2421886T3 (es) 2007-02-13 2008-02-12 Método para producción de un agente de representación de imágenes de diagnóstico por radiación
HK10104126.7A HK1138504A1 (en) 2007-02-13 2010-04-28 Method for production of radiation diagnostic imaging agent
US13/565,204 US8658132B2 (en) 2007-02-13 2012-08-02 Method for production of radiation diagnostic imaging agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007031692 2007-02-13
JP2007-031692 2007-02-13

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/526,667 A-371-Of-International US8343459B2 (en) 2007-02-13 2008-02-12 Method for production of radiation diagnostic imaging agent
US13/565,204 Division US8658132B2 (en) 2007-02-13 2012-08-02 Method for production of radiation diagnostic imaging agent

Publications (1)

Publication Number Publication Date
WO2008099800A1 true WO2008099800A1 (ja) 2008-08-21

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Application Number Title Priority Date Filing Date
PCT/JP2008/052231 WO2008099800A1 (ja) 2007-02-13 2008-02-12 放射性画像診断剤の製造方法

Country Status (10)

Country Link
US (2) US8343459B2 (ja)
EP (1) EP2119458B9 (ja)
JP (1) JP5258583B2 (ja)
KR (1) KR101485445B1 (ja)
CN (1) CN101636183B (ja)
CA (1) CA2678020C (ja)
ES (1) ES2421886T3 (ja)
HK (1) HK1138504A1 (ja)
TW (1) TWI406674B (ja)
WO (1) WO2008099800A1 (ja)

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EP2106808A1 (en) * 2006-12-21 2009-10-07 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
WO2010120368A2 (en) 2009-04-15 2010-10-21 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
JP2015500865A (ja) * 2011-12-21 2015-01-08 ジーイー・ヘルスケア・リミテッド クエン酸緩衝液中の１８ｆ−フルシクロビン組成物
JP2015530985A (ja) * 2012-08-09 2015-10-29 ジーイー・ヘルスケア・リミテッド １８ｆ−フルシクロビンの製造
JP2021512070A (ja) * 2018-01-24 2021-05-13 エーシー・イミューン・エス・アー Ｐｅｔ画像化のための診断用組成物、診断用組成物を製造するための方法及び診断におけるその使用
US11077216B2 (en) 2014-06-30 2021-08-03 Ge Healthcare Limited Formulation and method of synthesis
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US20130004414A1 (en) * 2011-06-30 2013-01-03 General Electric Company Devices and methods for reducing radiolysis of radioisotopes
US20130005958A1 (en) * 2011-06-30 2013-01-03 General Electric Company Devices and methods for reducing radiolysis of radioisotopes
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Cited By (16)

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Publication number Priority date Publication date Assignee Title
EP2106808A1 (en) * 2006-12-21 2009-10-07 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
EP2106808A4 (en) * 2006-12-21 2013-02-27 Nihon Mediphysics Co Ltd RADIOACTIVE DIAGNOSTIC IMAGING AGENT
US8790620B2 (en) 2006-12-21 2014-07-29 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
WO2009059977A1 (en) * 2007-11-07 2009-05-14 Ge Healthcare Bv Stabilization of radiopharmaceuticals
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JP2012524064A (ja) * 2009-04-15 2012-10-11 ランセウス メディカル イメージング， インコーポレイテッド アスコルビン酸による放射性医薬組成物の安定化
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CA2678020A1 (en) 2008-08-21
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TW200833362A (en) 2008-08-16
CA2678020C (en) 2015-03-24
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JP5258583B2 (ja) 2013-08-07
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US8658132B2 (en) 2014-02-25
US8343459B2 (en) 2013-01-01
US20100119448A1 (en) 2010-05-13
HK1138504A1 (en) 2010-08-27
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