PE20090699A1 - Metodos para preparar compuestos basados en imidazol - Google Patents

Metodos para preparar compuestos basados en imidazol

Info

Publication number
PE20090699A1
PE20090699A1 PE2008000641A PE2008000641A PE20090699A1 PE 20090699 A1 PE20090699 A1 PE 20090699A1 PE 2008000641 A PE2008000641 A PE 2008000641A PE 2008000641 A PE2008000641 A PE 2008000641A PE 20090699 A1 PE20090699 A1 PE 20090699A1
Authority
PE
Peru
Prior art keywords
formula
compound
methods
based compounds
imidazole
Prior art date
Application number
PE2008000641A
Other languages
English (en)
Inventor
Wu Wenxue
Yan Jie
Zhang Haiming
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39580118&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090699(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of PE20090699A1 publication Critical patent/PE20090699A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

REFERIDA A UN METODO DE PREPARACION DE UN COMPUESTO DERIVADO DE IMIDAZOL DE FORMULA (I), DONDE X ES ALQUILO C1-C20 OPCIONALMENTE SUSTITUIDO CON OH, ACETATO O HALOGENO; R1 ES ALQUILO C1-C20 OPCIONALMENTE SUSTITUIDO; R2 ES H, HALOGENO, NITRILO, NITRILO, ENTRE OTROS; R3 ES H, ALQUILO C1-C20, ARILO, ENTRE OTROS, DONDE EL PROCEDIMIENTO COMPRENDE PONER EN CONTACTO UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA FORMAR UNA MEZCLA DE ISOMEROS E Y Z DEL COMPUESTO DE FORMULA (I) Y PONER EN CONTACTO DICHA MEZCLA CON UN ACIDO FUERTE TAL COMO ACIDO YOHIDRICO, BROMHIDRICO, SULFURICO, ENTRE OTROS
PE2008000641A 2007-04-12 2008-04-11 Metodos para preparar compuestos basados en imidazol PE20090699A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92302907P 2007-04-12 2007-04-12

Publications (1)

Publication Number Publication Date
PE20090699A1 true PE20090699A1 (es) 2009-07-08

Family

ID=39580118

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000641A PE20090699A1 (es) 2007-04-12 2008-04-11 Metodos para preparar compuestos basados en imidazol

Country Status (23)

Country Link
US (2) US7812174B2 (es)
EP (1) EP2139864B1 (es)
JP (1) JP5398698B2 (es)
KR (1) KR20100015463A (es)
CN (1) CN101284817B (es)
AR (1) AR065980A1 (es)
AU (1) AU2008240251A1 (es)
BR (1) BRPI0810993A2 (es)
CA (1) CA2683445A1 (es)
CL (1) CL2008001042A1 (es)
CO (1) CO6231030A2 (es)
EA (1) EA017076B1 (es)
EC (1) ECSP099680A (es)
HK (1) HK1124842A1 (es)
IL (1) IL201075A0 (es)
MX (1) MX2009010903A (es)
NZ (1) NZ579691A (es)
PE (1) PE20090699A1 (es)
TW (1) TWI389891B (es)
UA (1) UA97664C2 (es)
UY (1) UY31013A1 (es)
WO (1) WO2008128041A2 (es)
ZA (2) ZA200906578B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI412362B (zh) * 2007-04-12 2013-10-21 Lexicon Pharmaceuticals Inc （ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式
AR065980A1 (es) * 2007-04-12 2009-07-15 Lexicon Pharmaceuticals Inc Metodos para preparar compuestos basados en imidazol
TW200920355A (en) * 2007-09-06 2009-05-16 Lexicon Pharmaceuticals Inc Compositions and methods for treating immunological and inflammatory diseases and disorders
TW201002698A (en) * 2008-06-18 2010-01-16 Lexicon Pharmaceuticals Inc Methods of preparing imidazole-based bicyclic compounds
AR074062A1 (es) * 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc Agonistas del receptor s1p para el tratamiento de la malaria cerebral y forma farmaceutica
CA2778807A1 (en) * 2009-10-26 2011-05-05 Lexicon Pharmaceuticals, Inc. Methods of preparing 1-(4-((1r,2s,3r)-1,2,3,4-tetrahydroxybutyl)-1h-imidazol-2-yl)ethanone
CN102082785A (zh) * 2010-11-24 2011-06-01 蓝帽子(厦门)文化传播有限公司 线上线下游戏数据交互传输的认证加密装置及其认证方法
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567194A (en) 1983-03-10 1986-01-28 The Coca-Cola Company 2-Acylimidazole compounds, their synthesis and use as medicinal agents
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
TWI412362B (zh) * 2007-04-12 2013-10-21 Lexicon Pharmaceuticals Inc （ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式
AR065980A1 (es) 2007-04-12 2009-07-15 Lexicon Pharmaceuticals Inc Metodos para preparar compuestos basados en imidazol

Also Published As

Publication number Publication date
MX2009010903A (es) 2009-10-26
UY31013A1 (es) 2008-09-02
EA017076B1 (ru) 2012-09-28
UA97664C2 (uk) 2012-03-12
EP2139864B1 (en) 2015-12-02
CN101284817A (zh) 2008-10-15
EP2139864A2 (en) 2010-01-06
IL201075A0 (en) 2010-05-17
EA200970939A1 (ru) 2010-04-30
BRPI0810993A2 (pt) 2018-10-16
CO6231030A2 (es) 2010-12-20
HK1124842A1 (en) 2009-07-24
JP5398698B2 (ja) 2014-01-29
NZ579691A (en) 2011-12-22
CA2683445A1 (en) 2008-10-23
US20080262241A1 (en) 2008-10-23
WO2008128041A3 (en) 2009-09-24
CN101284817B (zh) 2013-06-26
US20110071303A1 (en) 2011-03-24
TWI389891B (zh) 2013-03-21
AR065980A1 (es) 2009-07-15
KR20100015463A (ko) 2010-02-12
WO2008128041A2 (en) 2008-10-23
JP2010523706A (ja) 2010-07-15
ZA200906578B (en) 2010-11-24
ZA201006678B (en) 2012-05-30
TW200902502A (en) 2009-01-16
CL2008001042A1 (es) 2008-09-12
US8093280B2 (en) 2012-01-10
US7812174B2 (en) 2010-10-12
ECSP099680A (es) 2009-12-28
AU2008240251A1 (en) 2008-10-23

Similar Documents

Publication Publication Date Title
PE20090699A1 (es) Metodos para preparar compuestos basados en imidazol
AR067355A1 (es) Procesos para la preparacion de pirazoles
AR091651A1 (es) Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico
IN2015DN02573A (es)
UA109883C2 (uk) Спосіб отримання сполук для застосування як інгібіторів sglt2
AR066709A1 (es) Proceso para la produccion de pirazoles
EP4230631A3 (en) Process for making trisubstituted silyloxyethyl triflates
MX367525B (es) Derivados de ácido bisfenil-butanoico fosfónico sustituido como inhibidores de la endopeptidasa neutra (nep).
NZ601805A (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
EP3388426A3 (en) Compounds for protection of cells
MX352470B (es) Disales de acido malonico y metodo para preparar dihaluros de malonilo.
PT2462098E (pt) Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico
MX2010006787A (es) Análogos halogenados de agentes anti-fibroticos.
IN2014DN05739A (es)
EA201490998A1 (ru) Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты
MX2011008787A (es) Composicion limpiadora microelectronica basada en solvente organico acido multiproposito.
MX2010009926A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexancarboxilico.
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
ME00929B (me) NOVI POSTUPAK ZA DOBlJANJE KRISTALNOG OBLIKA V AGOMELATIN A
CL2014001156A1 (es) Metodo para reducir el nivel de acido urico en un sujeto con funcion renal dañada administrando un compuesto de formula (i).
MY149706A (en) Method for producing aqueous ?-sulfo fatty acid alkyl ester salt solution
IN2014CN04667A (es)
AR061420A1 (es) Metodos para preparar derivados de acido glutamico e intermediarios del mismo
UA115765C2 (uk) Спосіб ферментативного синтезу (7s)-3,4-диметоксибіцикло[4.2.0]окта-1,3,5-триєн-7-карбонової кислоти або її естерів та застосування в синтезі івабрадину та його солей
PE20141326A1 (es) Metodo de produccion de derivados de imidazol

Legal Events

Date Code Title Description
FC Refusal