CO6231030A2 - Metodos para preparar compuestos basados en imidazol como potentes inhibidores de respuesta inmune - Google Patents
Metodos para preparar compuestos basados en imidazol como potentes inhibidores de respuesta inmuneInfo
- Publication number
- CO6231030A2 CO6231030A2 CO09112457A CO09112457A CO6231030A2 CO 6231030 A2 CO6231030 A2 CO 6231030A2 CO 09112457 A CO09112457 A CO 09112457A CO 09112457 A CO09112457 A CO 09112457A CO 6231030 A2 CO6231030 A2 CO 6231030A2
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- compound
- optionally substituted
- hydrogen
- imidazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un método para preparar un compuesto de fórmula I:en donde: X es alquilo opcionalmente sustituido; R1 es alquilo opcionalmente sustituido; R2 es hidrógeno, halógeno, nitrilo, o alquilo opcionalmente sustituido, arilo, alquilarilo, arilalquilo, heteroalquilo, heterociclo, alquilheterociclo, o heterocicloalquilo; y R3 es hidrógeno o alquilo opcionalmente sustituido, arilo, alquilarilo, arilalquilo, heteroalquilo, heterociclo, alquilheterociclo, o heterocicloalquilo; que comprende: poner en contacto un compuesto de fórmula II:con un compuesto de fórmula III:bajo condiciones suficientes para la formación de una mezcla de isómeros E y Z de un compuesto de fórmula I; yponer en contacto la mezcla de isómeros E y Z con un ácido fuerte. 2.- El método de la reivindicación 1, en donde X es alquilo opcionalmente sustituido con uno o más grupos funcionales hidroxilo, acetato o halógeno. 3.- El método de la reivindicación 1, en donde R2 es hidrógeno. 4.- El método de la reivindicación 1, en donde R3 es hidrógeno. 5.- El método de la reivindicación 1, en donde el compuesto de fórmula I es de fórmula I(a):
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92302907P | 2007-04-12 | 2007-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6231030A2 true CO6231030A2 (es) | 2010-12-20 |
Family
ID=39580118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09112457A CO6231030A2 (es) | 2007-04-12 | 2009-10-09 | Metodos para preparar compuestos basados en imidazol como potentes inhibidores de respuesta inmune |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7812174B2 (es) |
| EP (1) | EP2139864B1 (es) |
| JP (1) | JP5398698B2 (es) |
| KR (1) | KR20100015463A (es) |
| CN (1) | CN101284817B (es) |
| AR (1) | AR065980A1 (es) |
| AU (1) | AU2008240251A1 (es) |
| BR (1) | BRPI0810993A2 (es) |
| CA (1) | CA2683445A1 (es) |
| CL (1) | CL2008001042A1 (es) |
| CO (1) | CO6231030A2 (es) |
| EA (1) | EA017076B1 (es) |
| EC (1) | ECSP099680A (es) |
| HK (1) | HK1124842A1 (es) |
| IL (1) | IL201075A0 (es) |
| MX (1) | MX2009010903A (es) |
| NZ (1) | NZ579691A (es) |
| PE (1) | PE20090699A1 (es) |
| TW (1) | TWI389891B (es) |
| UA (1) | UA97664C2 (es) |
| UY (1) | UY31013A1 (es) |
| WO (1) | WO2008128041A2 (es) |
| ZA (2) | ZA200906578B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI412362B (zh) * | 2007-04-12 | 2013-10-21 | Lexicon Pharmaceuticals Inc | （ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式 |
| UY31013A1 (es) * | 2007-04-12 | 2008-09-02 | Lexicon Pharmaceuticals Inc | Metodos para prepar compuestos basados en imidazol |
| TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
| TW201002698A (en) * | 2008-06-18 | 2010-01-16 | Lexicon Pharmaceuticals Inc | Methods of preparing imidazole-based bicyclic compounds |
| AR074062A1 (es) * | 2008-10-31 | 2010-12-22 | Lexicon Pharmaceuticals Inc | Agonistas del receptor s1p para el tratamiento de la malaria cerebral y forma farmaceutica |
| EP2493861A1 (en) * | 2009-10-26 | 2012-09-05 | Lexicon Pharmaceuticals, Inc. | Methods of preparing 1-(4-((1r,2s,3r)-1,2,3,4-tetrahydroxybutyl)-1h-imidazol-2-yl)ethanone |
| CN102082785A (zh) * | 2010-11-24 | 2011-06-01 | 蓝帽子(厦门)文化传播有限公司 | 线上线下游戏数据交互传输的认证加密装置及其认证方法 |
| WO2013049272A2 (en) | 2011-09-29 | 2013-04-04 | Theraceutix, Llc | Composition and method for treatment of symptoms associated with various skin conditions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4567194A (en) | 1983-03-10 | 1986-01-28 | The Coca-Cola Company | 2-Acylimidazole compounds, their synthesis and use as medicinal agents |
| US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TWI412362B (zh) * | 2007-04-12 | 2013-10-21 | Lexicon Pharmaceuticals Inc | （ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式 |
| UY31013A1 (es) | 2007-04-12 | 2008-09-02 | Lexicon Pharmaceuticals Inc | Metodos para prepar compuestos basados en imidazol |
-
2008
- 2008-04-08 UY UY31013A patent/UY31013A1/es not_active Application Discontinuation
- 2008-04-08 AR ARP080101446A patent/AR065980A1/es unknown
- 2008-04-10 TW TW097113079A patent/TWI389891B/zh active
- 2008-04-11 WO PCT/US2008/060032 patent/WO2008128041A2/en active Application Filing
- 2008-04-11 US US12/101,410 patent/US7812174B2/en active Active
- 2008-04-11 JP JP2010503232A patent/JP5398698B2/ja not_active Expired - Fee Related
- 2008-04-11 MX MX2009010903A patent/MX2009010903A/es active IP Right Grant
- 2008-04-11 BR BRPI0810993A patent/BRPI0810993A2/pt not_active Application Discontinuation
- 2008-04-11 CA CA002683445A patent/CA2683445A1/en not_active Abandoned
- 2008-04-11 NZ NZ579691A patent/NZ579691A/en unknown
- 2008-04-11 PE PE2008000641A patent/PE20090699A1/es not_active Application Discontinuation
- 2008-04-11 AU AU2008240251A patent/AU2008240251A1/en not_active Abandoned
- 2008-04-11 CN CN200810087095XA patent/CN101284817B/zh active Active
- 2008-04-11 EA EA200970939A patent/EA017076B1/ru not_active IP Right Cessation
- 2008-04-11 CL CL200801042A patent/CL2008001042A1/es unknown
- 2008-04-11 EP EP08745609.1A patent/EP2139864B1/en active Active
- 2008-04-11 KR KR1020097021115A patent/KR20100015463A/ko not_active Application Discontinuation
- 2008-11-04 UA UAA200911485A patent/UA97664C2/uk unknown
-
2009
- 2009-03-11 HK HK09102312.8A patent/HK1124842A1/xx unknown
- 2009-09-21 IL IL201075A patent/IL201075A0/en unknown
- 2009-09-21 ZA ZA2009/06578A patent/ZA200906578B/en unknown
- 2009-10-07 EC EC2009009680A patent/ECSP099680A/es unknown
- 2009-10-09 CO CO09112457A patent/CO6231030A2/es not_active Application Discontinuation
-
2010
- 2010-09-17 ZA ZA2010/06678A patent/ZA201006678B/en unknown
- 2010-09-20 US US12/885,738 patent/US8093280B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010523706A (ja) | 2010-07-15 |
| KR20100015463A (ko) | 2010-02-12 |
| CN101284817A (zh) | 2008-10-15 |
| US20080262241A1 (en) | 2008-10-23 |
| EA200970939A1 (ru) | 2010-04-30 |
| TW200902502A (en) | 2009-01-16 |
| US7812174B2 (en) | 2010-10-12 |
| WO2008128041A3 (en) | 2009-09-24 |
| BRPI0810993A2 (pt) | 2018-10-16 |
| TWI389891B (zh) | 2013-03-21 |
| AU2008240251A1 (en) | 2008-10-23 |
| JP5398698B2 (ja) | 2014-01-29 |
| UA97664C2 (uk) | 2012-03-12 |
| EP2139864A2 (en) | 2010-01-06 |
| ZA201006678B (en) | 2012-05-30 |
| IL201075A0 (en) | 2010-05-17 |
| HK1124842A1 (en) | 2009-07-24 |
| US20110071303A1 (en) | 2011-03-24 |
| WO2008128041A2 (en) | 2008-10-23 |
| US8093280B2 (en) | 2012-01-10 |
| CL2008001042A1 (es) | 2008-09-12 |
| PE20090699A1 (es) | 2009-07-08 |
| CA2683445A1 (en) | 2008-10-23 |
| EP2139864B1 (en) | 2015-12-02 |
| ZA200906578B (en) | 2010-11-24 |
| ECSP099680A (es) | 2009-12-28 |
| AR065980A1 (es) | 2009-07-15 |
| NZ579691A (en) | 2011-12-22 |
| MX2009010903A (es) | 2009-10-26 |
| CN101284817B (zh) | 2013-06-26 |
| UY31013A1 (es) | 2008-09-02 |
| EA017076B1 (ru) | 2012-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |