WO2008095880A1 - Beleuchtungseinrichtung für ein mikroskop - Google Patents
Beleuchtungseinrichtung für ein mikroskop Download PDFInfo
- Publication number
- WO2008095880A1 WO2008095880A1 PCT/EP2008/051306 EP2008051306W WO2008095880A1 WO 2008095880 A1 WO2008095880 A1 WO 2008095880A1 EP 2008051306 W EP2008051306 W EP 2008051306W WO 2008095880 A1 WO2008095880 A1 WO 2008095880A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microscope
- lighting device
- holder
- illumination device
- illumination
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
- G02B21/08—Condensers
- G02B21/082—Condensers for incident illumination only
Definitions
- the present invention relates to a lighting device for a microscope, in particular an incident illumination device for a stereomicroscope, using a plurality of point-shaped light sources arranged on a carrier element, such as a light-emitting diode, and a microscope with such a lighting device.
- a lighting device for a microscope in particular an incident illumination device for a stereomicroscope, using a plurality of point-shaped light sources arranged on a carrier element, such as a light-emitting diode, and a microscope with such a lighting device.
- a stereomicroscope system with a reflected-light illumination device wherein the stereomicroscope system has a vertical focus column to which a focus arm is mounted vertically displaceable.
- the focus arm extends arcuately away from the focus column and opens into an opening which serves to receive the actual stereomicroscope.
- several light-emitting diodes are arranged around the receiving opening for the stereomicroscope, on the one hand, and fixedly arranged along the arcuate part of the focus arm, on the other hand.
- light emitting diodes high power white light diodes are used.
- the light-emitting diodes can be operated individually or in groups, whereby the brightness can also be regulated individually or in groups.
- the light emitting diodes arranged around the receiving opening serve for steep reflected light illumination, while the light emitting diodes arranged along the arcuate part of the focus column provide oblique illumination (angular range of 15 degrees to 105 degrees).
- the LEDs are fixedly arranged on the focus arm.
- the elevation angles are fixed by the arrangement of the LEDs at a fixed azimuth angle.
- the azimuth angle ie the angle on the horizontal circle on which the light emitting diodes are located around the receiving opening
- flexible lighting from different azimuth and elevation angles is therefore not possible.
- Another disadvantage of the proposed arrangement is that the high-power diodes generate considerable heat, which is emitted to the focus arm, which in turn is connected to the focus column.
- Patent specification EP 1 150 154 B1 discloses an arrangement for (incident) illumination in microscopes with a ring carrier oriented around the optical axis, wherein the illumination means (white light diodes) are arranged in a plurality of concentric ring rows lying in a plane in the ring carrier.
- the plane of the ring carrier is perpendicular to the optical axis.
- the light-emitting diodes have a relatively small emission angle and are directed towards the optical axis of the microscope.
- the LEDs can also be interconnected in groups and are operated by a controllable constant current source.
- a disadvantage of this proposed lighting arrangement is also here that the azimuthal direction of the lighting to the object can be done only by the control of individual lighting means. Since these are arranged in a close distance to each other because of the homogeneity of the illumination to be achieved, the number desired angles to a large extent the number of illuminants to be provided.
- US Pat. No. 5,038,258 discloses a lighting arrangement which has a hemispherical carrier in the center of which the object plane of the microscope is placed. At different heights, i. Layers above the object plane are arranged on the carrier point-shaped light sources, such as LEDs, circular. Thus, here determine the number and type of arrangement of the LEDs, the possible elevation and azimuth angle, under which an object illumination is possible. The brightness of the LEDs can be controlled individually. A flexible angle with regard to the angle here also requires a large number of lighting means. Furthermore, the accessibility to the object is hindered by the dome-shaped arrangement of the LEDs on concentric circular rings.
- a lighting device according to the preamble of claim 1 is known, wherein the illumination device comprises a carriage for receiving one or more incandescent bulbs as the light source and a mountable on the microscope tube holder, wherein the carriage together with the holder to the tube axis on an intermediate piece is displaceable with a circular guide in a horizontal plane.
- the illumination device comprises a carriage for receiving one or more incandescent bulbs as the light source and a mountable on the microscope tube holder, wherein the carriage together with the holder to the tube axis on an intermediate piece is displaceable with a circular guide in a horizontal plane.
- the said intermediate piece and the attached arc-shaped holder for the carriage with the light source are fixed in their geometry, it is not apparent how the illumination device in the case of a lens change to a new lens can be adapted.
- the lighting device proposed there is not suitable.
- the attachment of the lighting device to the microscope tube leads to the aforementioned disadvantageous heat transfer to the microscope optics.
- DE 195 41 420 A1 discloses a stereomicroscope arrangement with a main observer and a co-observer microscope and a lighting unit which directs light via the lens common to the main and co-observer microscope in the direction of the object plane.
- the illumination unit is attached to the microscope and can be brought by rotation about the optical axis in an optimal position for each observer. The setting of different elevation and azimuth angles is not addressed in this document.
- US Pat. No. 5,570,228 discloses a transmitted-light illumination device with two or more frames each having a light source whose light is directed via an optical waveguide in the direction of the object plane.
- a suspension point of the light guide can be moved along a circular arc-shaped guide. By means of this adjustment, the elevation angle can be changed.
- DE 10 2005 034 829 A1 discloses a microscope with an operating slit lamp with laser light source, wherein the lighting device is displaceably mounted along a circular arc segment carrier, wherein the displacement takes place in a plane perpendicular to the object plane.
- the circular arc segment carrier is arranged on the rear side of the microscope housing.
- external lighting means is known.
- the illuminant is placed on a separate stand next to the microscope and directed at any angle to the object. If the angle between the object plane and the illumination axis is about 90 degrees, then one generally speaks of a steep illumination, which is used to observe pits in objects. At shallower illumination angles, an oblique illumination is obtained which serves to detect three-dimensional object structures.
- Object of the present invention is to provide a lighting device for a microscope using point-shaped light sources, with a flexible illumination from different azimuth and elevation wind is made possible without reorienting the bulbs, in particular for stereomicroscopes in a simple and reproducible manner To realize different contrasting.
- the illumination device according to the invention for a microscope using a plurality of point-shaped light sources arranged on a carrier element is characterized by a plurality of carrier elements for receiving a plurality of point-shaped light sources and a mountable to the microscope holder with an arcuate guide, wherein the carrier elements along this guide in a plane to the object of the microscope are mounted displaceably parallel or perpendicular to the optical axis plane.
- the holder is attachable to the microscope such that the centers of curvature of the arc lie in the vicinity of or on the optical axis of the microscope and the light source is aligned with the focal point or at a point near the focal point of the microscope.
- the carrier element along the guide is slidably mounted along the guide in a horizontal plane along an arc around the object, so that in relation to an object point in the object plane of the microscope different Liehe azimuth angle of the illumination are adjustable.
- the displacement of a carrier element can be carried out continuously or in steps.
- a holder with a plurality of superimposed arcuate guides or a plurality of superimposed brackets each with an arcuate guide conceivable. Since a plurality of point-shaped light sources are provided, it is expedient to turn them on or off individually or in groups and to regulate their brightness.
- the displacement of a carrier element along the arcuate guide of the holder allows the setting of a specific azimuth angle of the illumination axis fixed by the punctiform light source to an object point at the object level of a microscope.
- the position of the punctiform light source in or on the carrier element, the position of the carrier element on the holder and the position of the holder in relation to the object plane define the elevation angle (or height) from which the object illumination takes place.
- the invention allows different contrasting in microscopy with illumination from different azimuth and elevation angles. This is realized according to the invention by means of mechanical adjustment and / or by different control of lighting fixtures (point light sources).
- the purpose of this adjustability is inter alia to adapt the illumination to the shape of the object to avoid shadows or gloss on reflective specimens and to visualize the topography, the relief or other structures of the surface without rotation of the object. Markings on the holder allow in particular the reproducible adjustment of the carrier elements and thus the azimuth angle.
- a further advantage of the invention is that the punctiform light sources, such as light-emitting diodes (light-emitting semiconductor diodes), are accommodated in a carrier element, which in turn is fastened to a holder.
- the resulting heat is not delivered directly to the microscope (for example, the focus arm or the focus column), so that there is no risk of heat for the user of the microscope.
- the support elements can be optimally used for the release of heat (in geometry and material al), so that as little heat is transferred to the holder.
- the guide is designed as a circular arc or circular segment, through or near the center of curvature of the optical axis of the microscope extends.
- a closed arc of 360 ° is possible, but for better accessibility of the object, lower angles are preferred, in particular those of 90 ° to 180 °.
- a plurality of point-shaped light sources are provided per carrier element.
- the punctiform light sources are preferably arranged on a carrier element in a second plane, which expediently approximately contains the centers of curvature of the arc and is substantially perpendicular to the first plane of the guide plane, ie substantially perpendicular to the horizontal object plane.
- the light sources are then arranged so to speak one above the other within the support element, wherein an arrangement on a straight line one above the other, that is, for example, in the vertical direction or in a direction inclined to the object plane, or an arcuate arrangement may be advantageous.
- the light sources are again at a point near the focus point. tes of the microscope.
- An arcuate arrangement of the light sources on a carrier element has the advantage that the light sources all have the same distance to an object.
- a variation of the elevation angle is made in the said fixed arrangements of the light sources via the switching on of different light sources on a carrier element.
- the point-shaped light sources are arranged displaceably in a carrier element.
- the displacement of a light source along a carrier element can be done manually, but also controlled automatically.
- the arrangement of the displaceable light sources within a support element on the above-mentioned arc is perpendicular to the first plane of the guide plane, i. perpendicular to the object plane.
- different elevation angles can thus be realized with one or more light sources.
- one or more light sources fixed, another or more other light sources are slidably mounted on a support member.
- the holder of the illumination device itself can be designed to be displaceable in a substantially vertical direction.
- the vertical shift but are narrow limits due to the limited beam angle of the light sources set if the homogeneity of the lighting should be maintained or the light sources should not be aligned with great effort.
- LEDs light emitting diodes, German: light emitting diode
- High power white light diodes are particularly suitable for conventional contrasting methods in microscopy. Should it be desired to work with light in a certain spectral range, light emitting diodes with a corresponding emission spectrum or white light diodes with a corresponding filter are suitable.
- At least one stationary support element is provided on the guide of the support of the illumination device.
- the central support element is arranged as a fixed support member at the apex of the (circular) arcuate guide.
- Starting from a top view of carrier elements and object plane then define the central carrier element and an object point an O ° line, wherein the two displaceable support elements each by a certain displacement angle with respect to this O ° line, for example by plus or minus 45 ° or plus or minus 90 °, are displaceable.
- the radiation angles of light-emitting diodes are generally between 5 ° and 120 °. Depending on the application, smaller or larger emission angles are preferred.
- the guide of the holder of the illumination device can serve as a busbar, via which the point-shaped light sources are supplied.
- the point-shaped light sources can be supplied.
- the carrier element can be provided for each support element own busbar. If a plurality of punctiform light sources are present on the carrier element, then these can be controlled via an encoding.
- the illumination device according to the invention is designed as a microscope module.
- the holder of the illumination device has a connecting element for fastening the Lighting device to a microscope, in particular to a fixed focus column of a microscope or to an adjustable focus arm of a microscope, on.
- illumination coupled to the object is obtained, which is advantageous for exposures with different focal planes (image stacks).
- focal planes image stacks
- the attachment to a focus arm which can be adjusted in the focus direction results in optimal illumination in the focal plane. Both methods have their meaning in microscopy, in particular in contrasting methods.
- connection element can be designed as a single piece, which can be connected to the holder of the illumination device.
- connection element for fastening the illumination device is formed both on a fixed focus column and on an adjustable focus arm of a microscope.
- the lighting device can then be selectively attached to the fixed focus column or to the adjustable focus arm, whereby the light field is either fixed to the object or fixed to the focal plane.
- This aspect of the invention is expressly considered to be protectable in isolation, independently of the above-described lighting device.
- the lighting device can thus be realized with a holder with horizontal arcuate guide (see previous description), or be designed as conventional lighting. Without limiting the generality, this aspect of the invention will be further elaborated in the following with reference to the already described lighting device. A later claim of this aspect of the invention independently gig of the concrete lighting device is reserved at this point.
- the connecting element which is designed as a single piece and can be connected to the holder of the lighting device, according to this aspect of the invention forms both a suitable fastening option for the focus column and a suitable fastening device for the focus arm.
- the connecting element is correspondingly oriented or aligned and brought into contact with the illumination device on the one hand, and with the focus arm or focus column on the other hand.
- connection element has a bracket, whose one longitudinal side is designed for fastening the bracket to the focus column, whose other longitudinal side is designed to fasten the bracket to the focus arm.
- focus arm and focus pillar represent longitudinal profiles which have different widths and / or geometries (towards the object plane).
- the bracket can then be a U-shaped headband having on its two longitudinal sides two different U-shaped profiles for attachment to the focus column or to the focus arm. By simply turning the bracket by 180 °, an optional attachment to the focus column or the focus arm can thus be realized.
- connection element must have a further attachment interface to the illumination device.
- the bracket advantageously has at least one, in particular two, columns for fastening (the holder) of the illumination device to the connection element, for which purpose the holder or the illumination device in turn has a or has a plurality of corresponding recesses.
- the illumination device is then attached to the column (s). It is useful if the at least one column is perpendicular to the longitudinal direction of the bracket and extending in only one direction, starting from the bracket.
- the illumination device is thus connected via the column (s) and the bracket connecting the columns to the focus arm or the focus column of a microscope.
- the columns run in particular parallel to the optical axis of the microscope or parallel to the adjustment direction of the focus arm, and the bracket preferably runs in its longitudinal direction perpendicular to the column direction.
- the holder of the lighting device (or in general the lighting device) can be fastened in a specific position along a column. As a result, the height of the illumination device above the object plane can be adjusted or adjusted again.
- connection element allows a quick and easy installation of the illumination device in both positions (attachment to focus arm or focus column) without additional parts. It is only necessary to change the orientation of the connection element (or the retaining clip). For this purpose, the illumination device is removed from the connection element, this correspondingly reoriented (rotated by 180 °) and again connected to the illumination device. Subsequently, the assembly of the connecting element together with the illumination device to the focus arm or to the focus column. Depending on the construction, it is also conceivable first to connect the connection element accordingly. to mount the microscope and then set up the lighting device.
- FIG. 1 very schematically shows a side view of a microscope with illumination device according to the invention
- FIG. 2 very schematically shows a plan view of a lighting device according to the invention and an object plane of a microscope
- FIG. 3 shows a perspective view of a lighting device with a connecting element for fastening the lighting device to the focus arm of a microscope
- FIG. 4 shows the illumination device from FIG. 3 attached to the focus arm of a microscope
- FIG. 5 shows a lighting device in naval view with a connection element for fastening the illumination device to the focus column of a microscope
- FIG. 6 shows the illumination device from FIG. 5 mounted on the focus column of a microscope.
- the illumination device 1 is a side view of a microscope 10 with an illumination device 1.
- the illumination device 1 has two carrier elements 2 for receiving two dot-shaped dots each. miger light sources, here light-emitting diodes 4, and a holder 5 on.
- the microscope 10 is connected via a vertically movable focus arm 11 with a vertical focus column 12.
- the microscope 10 in turn has an eyepiece 13 and an objective 14, which generate a picture of an object 3 in a known manner.
- the illumination device 1 is connected to the focus column 12 via a connecting element, not shown in detail here.
- the holder 5 of the illumination device 1 carries a carrier element 2, which has two light-emitting diodes 4 whose illumination axes 7 are directed onto the object 3 (or the object plane).
- the corresponding elevation angles are given by ⁇ i and c * 2.
- the variation of the elevation angle ⁇ can therefore take place here by switching the light-emitting diodes 4.
- a change in the elevation angle can take place in that a carrier element 2 is fastened displaceably in the vertical direction on the holder 5, and / or that the holder 5 is itself displaceable in the vertical direction (here on the focus column 12).
- a carrier element 2 is fastened displaceably in the vertical direction on the holder 5, and / or that the holder 5 is itself displaceable in the vertical direction (here on the focus column 12).
- the object 3 continues to remain in the light cone of the LEDs 4.
- FIG. 2 very schematically shows a plan view of the lighting device 1 and the object plane with the object 3. Shown are the guide 6 of the holder 5 of the lighting device 1 (see FIG. 1) and three carrier elements 2. In this illustration, all three carrier elements 2 slidably mounted along the circular guide 6. Shown is a shift range of about 90 °. Thus, the azimuth angle ⁇ can thus be changed between 0 and 90 °. Of course, guides 6 are conceivable with a larger angular range and depending on the objective also makes sense. However, care should be taken that the accessibility to the object 3 is not unduly restricted.
- the emission angle ⁇ of the light-emitting diodes 4 (cf., FIG. 1) is likewise sketched in FIG. Typical radiation angles ⁇ are between 5 ° and 120 °. In the present case, the emission angle ⁇ is approximately 20 °, so that the object 3 lies almost completely in the light cone of the light-emitting diodes 4.
- the arcuate guide 6 of the carrier elements 2 lies in a horizontal plane (same plane of drawing in FIG. 2), which is parallel to the object plane and perpendicular to the optical axis 15, as defined by the microscope 10 , runs.
- FIG. 3 shows an arcuate arrangement of punctiform light sources 4 on a carrier element 2.
- the light-emitting diodes or punctiform light sources 4 can also be arranged displaceably within a carrier element 2 in order to make a change in the elevation angle ⁇ .
- FIG. 3 shows an illumination device 1 with three carrier elements 2, two carrier elements 2 of which are each mounted so as to be displaceable on a holder 5 along an arcuate guide 6.
- the middle of the three support elements 2 is fixedly arranged on the holder 5.
- Each carrier element 2 has three fixed point-shaped light sources, in this case light-emitting diodes 4, which, as already mentioned, are arranged in an arcuate (circular) arc in the vertical direction.
- the center of the arc segment lies with advantage in the object 3 (see FIG. A Ska Ia 18 allows the reproducible positioning of the support elements. 2
- the azimuth angle starting from the fixed central support element 2, can be adjusted within a range of ⁇ 15 ° to ⁇ 45 °. This adjustment has proven to be useful in practice.
- the two adjustable support members 2 each have a clamping screw 8, by means of which the corresponding support member 2 can be fixed in the selected position on the holder 5.
- the further possibilities of a magnetic fixation and an electronically controlled displacement of a carrier element 2 should be pointed out again here.
- the carrier elements 2 have U-shaped recesses which are present on the side facing away from the light-emitting diodes 4 for guidance along the holder 5. It is in this case, if in the upper part of the U-shaped recess, the support element 2 has an inner nose which engages in the groove of the guide 6.
- a power supply of the individual LEDs 4 can be realized if the guide 6 comprises a busbar, which is tapped from the carrier element 2. The control of the individual LEDs 4 would have to be done in this case via a coding. Alternatively, each LED 4 has its own power supply.
- a membrane keypad 9 which serves for the operation of the lighting device 1, wherein in addition to an on / off circuit, a brightness control and a circuit of the sequences of individual light-emitting diodes 4 or a group of light-emitting diodes 4 may be provided.
- the support elements 2 serve as a heat sink for the LEDs 4 and can be optimized in shape for a sufficient cooling effect (cooling fins, active cooling and the like). This is advantageous for the integration of high-performance light-emitting diodes (so-called power LEDs).
- the lighting device 1 can also be controlled remotely via a computer or the like.
- the arrangement of the light-emitting diodes 4 on a carrier 2 is advantageously designed such that the uppermost light-emitting diode 4 can be used for a steep reflected light illumination, the middle light-emitting diode 4 for oblique illumination and the lowermost light-emitting diode 4 for dark-wave illumination.
- the attachment of the LEDs 4 in a recess in the support member 2 allows a cover of the LEDs 4 to protect the user from burns and at the same time Protection of the diodes 4 itself.
- the cover can also be used to hold color filters, wherein, depending on the purpose, all the light-emitting diodes 4 can be filtered identically or differently. Due to the stepless or stepped displacement of the carrier elements 2 around the object 3 (see FIGS. 1 and 2), different types of illumination and directions can be realized in a simple manner without moving the object 3.
- the lighting unit 1 represents a self-contained module, which can be connected to a microscope, more particularly to a focus arm or a focus column of a microscope.
- the rear side (the side of the holder 5 facing away from the carrier elements 2) can be correspondingly designed for attachment to the microscope.
- a connection element 20 is provided according to a further aspect of the invention, which is to be connected to the illumination device 1 in order to attach the illumination device 1 to a microscope 10, more specifically optionally to the focus column 12 or the focus arm 11 (see FIG.
- the connecting element 20 is designed here as a single piece, which is to be connected to the holder 5 of the lighting device 1 via two columns.
- the two columns 21a, b are in turn attached to a bracket 22 of the connecting element 20 and extend starting from the bracket 22 in one direction and parallel to each other.
- the bracket 22 has on its longitudinal sides in each case two different profiles or U-shaped recesses 23a, b for fastening the bracket 22 to the focussing column 12 or to the focus arm 11.
- the illumination device 1 it is advantageous for the illumination device 1 to be displaceable on the pillars 21a, b of the connection element 20. stores. In this way, after attaching the connection element 20 to the focus arm 11 or to the focus column 12 of the microscope 10, a (vertical) displacement of the illumination device 1 can be made for purposes of adjustment or for purposes of further variation of the elevation angle.
- connection element 20 on the illumination device 1 shown in FIG. 3 this is provided for attachment to the focus arm 11 of the microscope 10 shown in FIG.
- FIG. 4 shows a perspective view of the illumination device 1 from FIG. 3, which is fastened to the focus arm 11 of a microscope 10.
- the microscope 10 is a stereomicroscope with an objective 14, followed by a microscope housing in which a zoom system is located.
- the magnification of the zoom system can be changed by operating the adjustment knob 17 for the zoom system.
- This is followed by a further housing attachment, in which the tube is accommodated, and on which the eyepieces 13 (see FIG.
- the operation of a stereomicroscope 10 is known per se and will therefore not be explained further.
- the actual microscope 10 is supported by a focus arm 11, which in turn is slidably mounted on a vertical focus column 12.
- the knob 16 allows the coarse / fine adjustment of the vertical height of the focus arm. This construction is known per se and should therefore not be further explained.
- the lighting device 1 is fastened in the position shown in FIG. 3 via the connection element 20 to the focus arm 11.
- the U-shaped profile 23a oriented towards the focus arm 11.
- the profile 23a engages the profile of the focus arm 11 and both parts can be fastened to one another by a conventional method of attachment (for example by screwing). If the focus arm 11 is displaced in the vertical direction by actuating the rotary knob 16, then the lighting device 1 moves with the focus arm 11. Thus, the illumination in the respective focal plane remains constant.
- the illumination unit 1 can be displaced in a vertical direction via the columns 21a, 21b, whereby fine adjustments are possible.
- the illumination axes 7 of the light-emitting diodes 4 strike the object 3 on the object plane 3 '.
- the object 3 lies on the optical axis 15 of the microscope 10, usually in its focus.
- FIGS. 5 and 6 show the orientation of the connection element on the illumination device 1 for fastening the same to the focus column 12 of the microscope 10 shown in FIG. 4.
- FIGS. 5 and 6 show the orientation of the connection element on the illumination device 1 for fastening the same to the focus column 12 of the microscope 10 shown in FIG. 4.
- connection element 20 is removed from the illumination device 1, rotated from top to bottom and from left to right (ie, in each case by 180 °) and then connected to the illumination device 1 again.
- the clamping screws 24 can be seen, by means of which the lighting device 1 along the columns 21a, 21b can be moved and fixed.
- the recess or the U-shaped profile 23b now points outwards. This profile is designed according to the profile of the focus column 12, so that engagement of the profiles and attachment of the connection element 20 to the focus column 12 is possible.
- FIG. 6 shows the mounted state in which the illumination device 1 is fastened via the connection element 20 to the focus column 12 of the microscope 10 (see FIG. For the sake of clarity, the details of FIG. 4 regarding the microscope in FIG. 6 have been omitted.
- a fixed illumination which is always directed to the object 3
- This type of illumination is an advantage when recording image stacks, such as three-dimensional imaging.
- the assembly is carried out by first the connecting element 20 is fixed in the manner shown in Figure 6 on the focus column 12. Subsequently, the lighting device 1 is placed on the columns 21a, 21b and in turn fixed with the clamping screws 24. This approach has proven to be particularly useful in practice.
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Microscoopes, Condenser (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/525,424 US8331020B2 (en) | 2007-02-09 | 2008-02-04 | Illumination device for a microscope |
JP2009548671A JP5271278B2 (ja) | 2007-02-09 | 2008-02-04 | 顕微鏡の照明装置 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007006584A DE102007006584B3 (de) | 2007-02-09 | 2007-02-09 | Beleuchtungseinrichtung für ein Mikroskop |
DE102007006584.3 | 2007-02-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008095880A1 true WO2008095880A1 (de) | 2008-08-14 |
Family
ID=39400033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/051306 WO2008095880A1 (de) | 2007-02-09 | 2008-02-04 | Beleuchtungseinrichtung für ein mikroskop |
Country Status (4)
Country | Link |
---|---|
US (1) | US8331020B2 (de) |
JP (1) | JP5271278B2 (de) |
DE (1) | DE102007006584B3 (de) |
WO (1) | WO2008095880A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8585567B2 (en) * | 2007-12-11 | 2013-11-19 | Tokitae Llc | Systems, devices, and methods including paramagnetic oscillation, rotation and translation of hemozoin asymmetric nanoparticles in response to multi-harmonic optical detection of the presence of hemozoin |
US8385997B2 (en) | 2007-12-11 | 2013-02-26 | Tokitae Llc | Spectroscopic detection of malaria via the eye |
US8781184B2 (en) | 2010-02-10 | 2014-07-15 | Tokitae Llc | Systems, devices, and methods for detection of malaria |
US9044141B2 (en) * | 2010-02-10 | 2015-06-02 | Tokitae Llc | Systems, devices, and methods including a dark-field reflected-illumination apparatus |
US9081175B2 (en) * | 2012-03-23 | 2015-07-14 | Lumos Technology Co., Ltd. | Fluorescence observation device, domed base and fluorescence microscope provided with multiple light sources having different illumination angles |
CN103777336B (zh) * | 2012-10-22 | 2017-09-05 | 承奕科技股份有限公司 | 显微光学撷取装置用荧光辅具模组、基架及该装置 |
US9557551B2 (en) | 2013-07-18 | 2017-01-31 | University Of Maine System | System and apparatus for illuminating a specimen |
JP6596492B2 (ja) | 2014-10-14 | 2019-10-23 | ナノトロニクス イメージング インコーポレイテッド | 明視野暗視野対物レンズを使用する独自の斜角照明法及びそれに関連した撮像方法 |
EP3121637B1 (de) * | 2015-07-24 | 2021-09-01 | Leica Instruments (Singapore) Pte. Ltd. | Mikroskop und verfahren zum erzeugen eines kombinierten bildes aus mehreren einzelbildern eines objekts |
ES2599056B2 (es) * | 2015-07-31 | 2017-07-07 | Pablo ALBERTOS SÁNCHEZ | Dispositivo para ensayar una muestra de células |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5038258A (en) * | 1989-03-02 | 1991-08-06 | Carl-Zeiss-Stiftung | Illuminating arrangement for illuminating an object with incident light |
US5570228A (en) * | 1991-04-19 | 1996-10-29 | Edge Scientific Instrument Company Llc | Fiber optic illumination system and method for a high definition light microscope |
WO1999062442A1 (de) * | 1998-05-29 | 1999-12-09 | Wavelight Laser Technologie Gmbh | Vorrichtung für eine medizinische behandlung mit einer lichtquelle |
WO2001061324A1 (en) * | 2000-02-17 | 2001-08-23 | The University Of Chicago | Fluorescence microscopy methods and devices using light emission diodes |
JP2005006960A (ja) * | 2003-06-19 | 2005-01-13 | Olympus Corp | 手術用顕微鏡システム |
US20060091825A1 (en) * | 2004-11-01 | 2006-05-04 | Gil Abramovich | Reconfigurable linescan illumination |
DE102005036230B3 (de) * | 2005-08-02 | 2006-11-23 | Leica Microsystems (Schweiz) Ag | Stereomikroskop mit Auflichtbeleuchtungseinrichtung |
DE102005034829A1 (de) * | 2005-07-26 | 2007-02-01 | Leica Microsystems (Schweiz) Ag | Mikroskop mit einer Operationsspaltlampe mit Laserlichtquelle |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT137806B (de) * | 1933-03-11 | 1934-06-11 | Zeiss Carl Fa | Vorrichtung zur Beleuchtung mikroskopischer Objekte mit auffallendem Lichte. |
US2208882A (en) * | 1939-03-22 | 1940-07-23 | Paper Chemistry Inst | Microscope |
CH689954A5 (de) | 1994-11-19 | 2000-02-15 | Zeiss Carl Fa | Stereomikroskop-Anordnung mit geeigneter Beleuchtungseinheit. |
EP1150154B1 (de) * | 2000-04-26 | 2003-03-26 | COBRA electronic GmbH | Anordnung und Verfahren zur ringförmigen Beleuchtung, insbesondere zur Auflichtbeleuchtung bei Mikroskopen |
US6850637B1 (en) * | 2000-06-28 | 2005-02-01 | Teradyne, Inc. | Lighting arrangement for automated optical inspection system |
JP3496644B2 (ja) * | 2001-01-12 | 2004-02-16 | シーシーエス株式会社 | 検査用照明装置 |
JP4360808B2 (ja) * | 2001-04-03 | 2009-11-11 | ベルス・メステヒニーク・ゲーエムベーハー | 照明装置を備えた測定装置及び物体の照明のための方法 |
US6874911B2 (en) * | 2002-04-09 | 2005-04-05 | Ccs, Inc. | Light irradiating unit, lighting unit and method for manufacturing lighting unit |
JP3889992B2 (ja) * | 2002-05-17 | 2007-03-07 | 株式会社ミツトヨ | リング照明装置 |
JP2005017905A (ja) * | 2003-06-27 | 2005-01-20 | Olympus Corp | 実体顕微鏡 |
JP4588525B2 (ja) * | 2005-05-02 | 2010-12-01 | 株式会社ミツトヨ | 画像プローブ |
-
2007
- 2007-02-09 DE DE102007006584A patent/DE102007006584B3/de active Active
-
2008
- 2008-02-04 WO PCT/EP2008/051306 patent/WO2008095880A1/de active Application Filing
- 2008-02-04 US US12/525,424 patent/US8331020B2/en active Active
- 2008-02-04 JP JP2009548671A patent/JP5271278B2/ja active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5038258A (en) * | 1989-03-02 | 1991-08-06 | Carl-Zeiss-Stiftung | Illuminating arrangement for illuminating an object with incident light |
US5570228A (en) * | 1991-04-19 | 1996-10-29 | Edge Scientific Instrument Company Llc | Fiber optic illumination system and method for a high definition light microscope |
WO1999062442A1 (de) * | 1998-05-29 | 1999-12-09 | Wavelight Laser Technologie Gmbh | Vorrichtung für eine medizinische behandlung mit einer lichtquelle |
WO2001061324A1 (en) * | 2000-02-17 | 2001-08-23 | The University Of Chicago | Fluorescence microscopy methods and devices using light emission diodes |
JP2005006960A (ja) * | 2003-06-19 | 2005-01-13 | Olympus Corp | 手術用顕微鏡システム |
US20060091825A1 (en) * | 2004-11-01 | 2006-05-04 | Gil Abramovich | Reconfigurable linescan illumination |
DE102005034829A1 (de) * | 2005-07-26 | 2007-02-01 | Leica Microsystems (Schweiz) Ag | Mikroskop mit einer Operationsspaltlampe mit Laserlichtquelle |
DE102005036230B3 (de) * | 2005-08-02 | 2006-11-23 | Leica Microsystems (Schweiz) Ag | Stereomikroskop mit Auflichtbeleuchtungseinrichtung |
Also Published As
Publication number | Publication date |
---|---|
US8331020B2 (en) | 2012-12-11 |
JP2010518435A (ja) | 2010-05-27 |
DE102007006584B3 (de) | 2008-06-19 |
US20100103511A1 (en) | 2010-04-29 |
JP5271278B2 (ja) | 2013-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008095880A1 (de) | Beleuchtungseinrichtung für ein mikroskop | |
DE19861507B3 (de) | Umgekehrtes Mikroskop | |
DE69116818T2 (de) | Mikroskop mit einer Schärfeneinstelleinrichtung | |
DE10309138A1 (de) | Mikroskopvorrichtung | |
DE102005036230B3 (de) | Stereomikroskop mit Auflichtbeleuchtungseinrichtung | |
DD202477A5 (de) | Durchlicht- und/oder auflicht-inversmikroskop | |
DE7931427U1 (de) | Zwischentubus mit Höhenverstellung für Mikroskope | |
EP2746831B1 (de) | Digitales Mikroskopsystem | |
CH687424A5 (de) | Operationsmikroskop. | |
DE10359733A1 (de) | Afokales Zoomsystem | |
DE102006022592B4 (de) | Mikroskop mit Beleuchtungseinheit | |
DE60222624T2 (de) | Mikroskop mit veränderlicher Vergrösserung | |
WO2004040352A2 (de) | Stereomikroskop, bzw. zusatz für ein stereomikroskop | |
CH651139A5 (de) | Strahlenumlenkvorrichtung fuer ein optisches instrument, insbesondere ein mikroskop. | |
DE10323091A1 (de) | OP-Feldbeleuchtungsvorrichtung | |
EP1861743B1 (de) | Ringlicht für ein optisches oder medizinisches gerät | |
DE102010031678B4 (de) | Schnelle, variable Einfallswinkelbeleuchtung für Maschinensichtinspektionssystem | |
DE10027196A1 (de) | Video-Stereoskopmikroskop | |
EP2252908A2 (de) | Objektivwechsler mit auflichtbeleuchtung für lichtmikroskope | |
DE10339619A1 (de) | Stereomikroskop mit integrierter Auflicht-Beleuchtungseinrichtung | |
DE10130621B4 (de) | Mikroskoptubus | |
DE102006048056A1 (de) | Verfahren und Anordnung zum Fokussieren von Objektiven, Objekten und Kondensoren bei Mikroskopen | |
DE10106696A1 (de) | Mikroskop | |
DE9408066U1 (de) | Auflichtbeleuchtung für Stereomikroskope | |
DE102018101908B4 (de) | Durchlichtmikroskop mit Zusatzbeleuchtungsmodul |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08708610 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2009548671 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12525424 Country of ref document: US |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 08708610 Country of ref document: EP Kind code of ref document: A1 |