WO2008088039A1 - ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法 - Google Patents

ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法 Download PDF

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Publication number
WO2008088039A1
WO2008088039A1 PCT/JP2008/050602 JP2008050602W WO2008088039A1 WO 2008088039 A1 WO2008088039 A1 WO 2008088039A1 JP 2008050602 W JP2008050602 W JP 2008050602W WO 2008088039 A1 WO2008088039 A1 WO 2008088039A1
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WO
WIPO (PCT)
Prior art keywords
medicinal composition
stabilization
producing
same
composition containing
Prior art date
Application number
PCT/JP2008/050602
Other languages
English (en)
French (fr)
Inventor
Tsutomu Harada
Kenji Wakabayashi
Yasunori Miyamoto
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to US12/523,679 priority Critical patent/US20100016362A1/en
Priority to EP08703452A priority patent/EP2127651A4/en
Publication of WO2008088039A1 publication Critical patent/WO2008088039A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

　本発明は、投与方法の選択肢を広げ、患者の服薬コンプライアンスの向上を図るため、痴呆症（認知症）の治療薬として既に利用されているドネペジルの新たな医薬組成物を提供することを目的とする。本発明は、ドネペジルまたはその薬理学的に許容され得る塩と、天然高分子物質と、を含む医薬組成物であって、エデト酸塩、亜硫酸塩、ジブチルヒドロキシトルエンまたはブチルヒドロキシアニソールのいずれか１種以上を含む医薬組成物を提供する。
PCT/JP2008/050602 2007-01-19 2008-01-18 ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法 WO2008088039A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/523,679 US20100016362A1 (en) 2007-01-19 2008-01-18 Stabilized pharmaceutical composition containing donepezil, process of producing same and method for stabilization
EP08703452A EP2127651A4 (en) 2007-01-19 2008-01-18 STABILIZED MEDICINAL COMPOSITION COMPRISING DONEEPZIL, PROCESS FOR PRODUCING AND STABILIZING SUCH A COMPOSITION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-010783 2007-01-19
JP2007010783 2007-01-19

Publications (1)

Publication Number Publication Date
WO2008088039A1 true WO2008088039A1 (ja) 2008-07-24

Family

ID=39636039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050602 WO2008088039A1 (ja) 2007-01-19 2008-01-18 ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法

Country Status (4)

Country Link
US (1) US20100016362A1 (ja)
EP (1) EP2127651A4 (ja)
JP (1) JP5205067B2 (ja)
WO (1) WO2008088039A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113325A1 (ja) * 2009-04-03 2010-10-07 日医工ファーマ株式会社 ペクチン含有ゼリー製剤
WO2010113324A1 (ja) * 2009-04-03 2010-10-07 日医工ファーマ株式会社 ペクチン含有ゼリー製剤

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366378A1 (en) 2010-03-01 2011-09-21 Dexcel Pharma Technologies Ltd. Sustained-release donepezil formulations
JP5611672B2 (ja) * 2010-05-28 2014-10-22 ゼリア新薬工業株式会社 経口ゼリー剤
WO2012053016A1 (en) 2010-10-22 2012-04-26 Cadila Healthcare Limited Sustained release pharmaceutical compositions of donepezil
JP2012188383A (ja) * 2011-03-10 2012-10-04 Towa Yakuhin Kk ドネペジル塩酸塩の内用液剤
WO2014007774A1 (en) 2012-07-02 2014-01-09 Mahmut Bilgic Water soluble formulations comprising a piperidine derivative active agent
JP2017201923A (ja) * 2016-05-11 2017-11-16 ユニテックフーズ株式会社 ゼリー食品
JP6761664B2 (ja) * 2016-05-11 2020-09-30 ユニテックフーズ株式会社 物品のゼリー包埋剤
JPWO2019230971A1 (ja) 2018-05-31 2021-07-08 千寿製薬株式会社 ジブチルヒドロキシトルエンの含量低下が抑制された眼科用液剤
CN110672738A (zh) * 2019-09-29 2020-01-10 重庆健能医药开发有限公司 一种复方聚乙二醇电解质散中聚乙二醇4000含量测定方法
CN114246824B (zh) * 2022-01-24 2023-08-22 南京康川济医药科技有限公司 一种多奈哌齐口服凝胶及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1192402A (ja) * 1997-07-24 1999-04-06 Eisai Co Ltd 製剤組成物及びその製造方法
JPH11106353A (ja) 1997-10-01 1999-04-20 Eisai Co Ltd 光安定化組成物
JPH11228450A (ja) * 1997-03-28 1999-08-24 Eisai Co Ltd 苦味等を隠蔽した経口薬剤
JP2000136134A (ja) 1998-08-28 2000-05-16 Eisai Co Ltd 薬物の苦味等を軽減した組成物
WO2006070930A1 (en) * 2004-12-27 2006-07-06 Eisai R & D Management Co., Ltd. Method for stabilizing anti-dementia drug

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7273618B2 (en) * 1998-12-09 2007-09-25 Chiron Corporation Method for administering agents to the central nervous system
WO2003082224A1 (fr) * 2002-03-29 2003-10-09 Kose Corporation Preparation cosmetique
US20030225031A1 (en) * 2002-05-21 2003-12-04 Quay Steven C. Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid
US20050232990A1 (en) * 2003-12-31 2005-10-20 Garth Boehm Donepezil formulations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11228450A (ja) * 1997-03-28 1999-08-24 Eisai Co Ltd 苦味等を隠蔽した経口薬剤
JPH1192402A (ja) * 1997-07-24 1999-04-06 Eisai Co Ltd 製剤組成物及びその製造方法
JPH11106353A (ja) 1997-10-01 1999-04-20 Eisai Co Ltd 光安定化組成物
JP2000136134A (ja) 1998-08-28 2000-05-16 Eisai Co Ltd 薬物の苦味等を軽減した組成物
WO2006070930A1 (en) * 2004-12-27 2006-07-06 Eisai R & D Management Co., Ltd. Method for stabilizing anti-dementia drug

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2127651A4

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113325A1 (ja) * 2009-04-03 2010-10-07 日医工ファーマ株式会社 ペクチン含有ゼリー製剤
WO2010113324A1 (ja) * 2009-04-03 2010-10-07 日医工ファーマ株式会社 ペクチン含有ゼリー製剤
US20120022104A1 (en) * 2009-04-03 2012-01-26 Kurato Takanashi Pectin-containing jelly formulation
JP5492871B2 (ja) * 2009-04-03 2014-05-14 日医工株式会社 ペクチン含有ゼリー製剤
JP5514193B2 (ja) * 2009-04-03 2014-06-04 日医工株式会社 ペクチン含有ゼリー製剤
US9125809B2 (en) 2009-04-03 2015-09-08 Nichi-Iko Pharmaceutical Co., Ltd. Pectin-containing jelly formulation

Also Published As

Publication number Publication date
JP2008195714A (ja) 2008-08-28
US20100016362A1 (en) 2010-01-21
EP2127651A4 (en) 2012-08-01
JP5205067B2 (ja) 2013-06-05
EP2127651A1 (en) 2009-12-02

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