WO2008088039A1 - ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法 - Google Patents
ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法 Download PDFInfo
- Publication number
- WO2008088039A1 WO2008088039A1 PCT/JP2008/050602 JP2008050602W WO2008088039A1 WO 2008088039 A1 WO2008088039 A1 WO 2008088039A1 JP 2008050602 W JP2008050602 W JP 2008050602W WO 2008088039 A1 WO2008088039 A1 WO 2008088039A1
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- WO
- WIPO (PCT)
- Prior art keywords
- medicinal composition
- stabilization
- producing
- same
- composition containing
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本発明は、投与方法の選択肢を広げ、患者の服薬コンプライアンスの向上を図るため、痴呆症(認知症)の治療薬として既に利用されているドネペジルの新たな医薬組成物を提供することを目的とする。本発明は、ドネペジルまたはその薬理学的に許容され得る塩と、天然高分子物質と、を含む医薬組成物であって、エデト酸塩、亜硫酸塩、ジブチルヒドロキシトルエンまたはブチルヒドロキシアニソールのいずれか1種以上を含む医薬組成物を提供する。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/523,679 US20100016362A1 (en) | 2007-01-19 | 2008-01-18 | Stabilized pharmaceutical composition containing donepezil, process of producing same and method for stabilization |
EP08703452A EP2127651A4 (en) | 2007-01-19 | 2008-01-18 | STABILIZED MEDICINAL COMPOSITION COMPRISING DONEEPZIL, PROCESS FOR PRODUCING AND STABILIZING SUCH A COMPOSITION |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007010783 | 2007-01-19 | ||
JP2007-010783 | 2007-01-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008088039A1 true WO2008088039A1 (ja) | 2008-07-24 |
Family
ID=39636039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/050602 WO2008088039A1 (ja) | 2007-01-19 | 2008-01-18 | ドネペジルを含有する安定化医薬組成物、その製造方法、及び安定化方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100016362A1 (ja) |
EP (1) | EP2127651A4 (ja) |
JP (1) | JP5205067B2 (ja) |
WO (1) | WO2008088039A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010113324A1 (ja) * | 2009-04-03 | 2010-10-07 | 日医工ファーマ株式会社 | ペクチン含有ゼリー製剤 |
WO2010113325A1 (ja) * | 2009-04-03 | 2010-10-07 | 日医工ファーマ株式会社 | ペクチン含有ゼリー製剤 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2366378A1 (en) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
JP5611672B2 (ja) * | 2010-05-28 | 2014-10-22 | ゼリア新薬工業株式会社 | 経口ゼリー剤 |
WO2012053016A1 (en) | 2010-10-22 | 2012-04-26 | Cadila Healthcare Limited | Sustained release pharmaceutical compositions of donepezil |
JP2012188383A (ja) * | 2011-03-10 | 2012-10-04 | Towa Yakuhin Kk | ドネペジル塩酸塩の内用液剤 |
WO2014007774A1 (en) | 2012-07-02 | 2014-01-09 | Mahmut Bilgic | Water soluble formulations comprising a piperidine derivative active agent |
JP2017201923A (ja) * | 2016-05-11 | 2017-11-16 | ユニテックフーズ株式会社 | ゼリー食品 |
JP6761664B2 (ja) * | 2016-05-11 | 2020-09-30 | ユニテックフーズ株式会社 | 物品のゼリー包埋剤 |
JPWO2019230971A1 (ja) | 2018-05-31 | 2021-07-08 | 千寿製薬株式会社 | ジブチルヒドロキシトルエンの含量低下が抑制された眼科用液剤 |
CN110672738A (zh) * | 2019-09-29 | 2020-01-10 | 重庆健能医药开发有限公司 | 一种复方聚乙二醇电解质散中聚乙二醇4000含量测定方法 |
CN114246824B (zh) * | 2022-01-24 | 2023-08-22 | 南京康川济医药科技有限公司 | 一种多奈哌齐口服凝胶及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1192402A (ja) * | 1997-07-24 | 1999-04-06 | Eisai Co Ltd | 製剤組成物及びその製造方法 |
JPH11106353A (ja) | 1997-10-01 | 1999-04-20 | Eisai Co Ltd | 光安定化組成物 |
JPH11228450A (ja) * | 1997-03-28 | 1999-08-24 | Eisai Co Ltd | 苦味等を隠蔽した経口薬剤 |
JP2000136134A (ja) | 1998-08-28 | 2000-05-16 | Eisai Co Ltd | 薬物の苦味等を軽減した組成物 |
WO2006070930A1 (en) * | 2004-12-27 | 2006-07-06 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7273618B2 (en) * | 1998-12-09 | 2007-09-25 | Chiron Corporation | Method for administering agents to the central nervous system |
US20050214240A1 (en) * | 2002-03-29 | 2005-09-29 | Toshiyuki Ito | Cosmetic preparation |
US20030225031A1 (en) * | 2002-05-21 | 2003-12-04 | Quay Steven C. | Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid |
EP1776089A2 (en) * | 2003-12-31 | 2007-04-25 | Actavis Group hf | Donepezil formulations |
-
2008
- 2008-01-18 US US12/523,679 patent/US20100016362A1/en not_active Abandoned
- 2008-01-18 EP EP08703452A patent/EP2127651A4/en not_active Withdrawn
- 2008-01-18 JP JP2008009036A patent/JP5205067B2/ja active Active
- 2008-01-18 WO PCT/JP2008/050602 patent/WO2008088039A1/ja active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11228450A (ja) * | 1997-03-28 | 1999-08-24 | Eisai Co Ltd | 苦味等を隠蔽した経口薬剤 |
JPH1192402A (ja) * | 1997-07-24 | 1999-04-06 | Eisai Co Ltd | 製剤組成物及びその製造方法 |
JPH11106353A (ja) | 1997-10-01 | 1999-04-20 | Eisai Co Ltd | 光安定化組成物 |
JP2000136134A (ja) | 1998-08-28 | 2000-05-16 | Eisai Co Ltd | 薬物の苦味等を軽減した組成物 |
WO2006070930A1 (en) * | 2004-12-27 | 2006-07-06 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
Non-Patent Citations (1)
Title |
---|
See also references of EP2127651A4 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010113324A1 (ja) * | 2009-04-03 | 2010-10-07 | 日医工ファーマ株式会社 | ペクチン含有ゼリー製剤 |
WO2010113325A1 (ja) * | 2009-04-03 | 2010-10-07 | 日医工ファーマ株式会社 | ペクチン含有ゼリー製剤 |
US20120022104A1 (en) * | 2009-04-03 | 2012-01-26 | Kurato Takanashi | Pectin-containing jelly formulation |
JP5492871B2 (ja) * | 2009-04-03 | 2014-05-14 | 日医工株式会社 | ペクチン含有ゼリー製剤 |
JP5514193B2 (ja) * | 2009-04-03 | 2014-06-04 | 日医工株式会社 | ペクチン含有ゼリー製剤 |
US9125809B2 (en) | 2009-04-03 | 2015-09-08 | Nichi-Iko Pharmaceutical Co., Ltd. | Pectin-containing jelly formulation |
Also Published As
Publication number | Publication date |
---|---|
EP2127651A4 (en) | 2012-08-01 |
JP5205067B2 (ja) | 2013-06-05 |
US20100016362A1 (en) | 2010-01-21 |
JP2008195714A (ja) | 2008-08-28 |
EP2127651A1 (en) | 2009-12-02 |
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