WO2008050396A1 - Analyseur - Google Patents

Analyseur Download PDF

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Publication number
WO2008050396A1
WO2008050396A1 PCT/JP2006/321136 JP2006321136W WO2008050396A1 WO 2008050396 A1 WO2008050396 A1 WO 2008050396A1 JP 2006321136 W JP2006321136 W JP 2006321136W WO 2008050396 A1 WO2008050396 A1 WO 2008050396A1
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WO
WIPO (PCT)
Prior art keywords
sample
timing
processing
analysis
specimen
Prior art date
Application number
PCT/JP2006/321136
Other languages
English (en)
Japanese (ja)
Inventor
Shoji Iguchi
Original Assignee
Olympus Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corporation filed Critical Olympus Corporation
Priority to PCT/JP2006/321136 priority Critical patent/WO2008050396A1/fr
Priority to JP2008540827A priority patent/JPWO2008050396A1/ja
Publication of WO2008050396A1 publication Critical patent/WO2008050396A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling

Definitions

  • the present invention relates to an analyzer that analyzes a first sample and a second sample that requires an analysis time different from that of the first sample.
  • an analyzer for performing an immunological test includes a reaction mechanism for reacting a sample and a reagent in a reaction container, a removal mechanism for removing unreacted substances in the reaction container, and light generated from a reaction solution of each reagent and the sample.
  • Measuring mechanisms are arranged on each of a plurality of turntables, and further provided with a plurality of dispensing transfer mechanisms for transferring specimens, reagents and reaction solutions, and controlling the processing timing of each mechanism.
  • immunological examinations of various analysis contents are performed (for example, see Patent Document 1).
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2005-164508
  • the present invention has been made in view of the above-described drawbacks of the prior art, and even when analysis processing is performed on another specimen, the specimen obtained urgently. It is an object of the present invention to provide an analyzer that can quickly perform the analysis process.
  • an analyzer analyzes a first sample and a second sample that requires a different analysis time from the first sample. No processing is performed on the first sample between the processing timing for the predetermined first sample and the processing timing for the first sample processed next to the predetermined first sample. A blank period is provided, and when the analysis of the second sample is necessary, the process for the second sample is performed during the blank period by overtaking each process for the first sample. .
  • the analyzer includes a control unit that controls processing timing of each mechanism constituting the analyzer, and the control unit processes the first sample in the mechanism.
  • the blank period is generated by controlling timing.
  • control means generates the blank period by delaying the analysis start timing for the first sample to be processed next to the predetermined first sample. It is characterized by.
  • control means generates the blank period corresponding to the analysis time of each first specimen and the analysis time of each second specimen obtained in advance.
  • the generation period pattern of the blank period corresponding to the first sample and the second sample to be analyzed is selected from the timing pattern group, and the blank period is determined according to the generation timing pattern of the selected blank period. It is characterized by generating.
  • the mechanism for processing the second sample has the empty space.
  • the mechanism for processing the second sample is provided with a transfer mechanism for transferring the reaction solution of the second sample or the second sample and the reagent. .
  • the transfer mechanism is an arm-shaped transfer mechanism that transfers a liquid to a predetermined position at a predetermined timing.
  • the analyzer provides the reaction solution of the second sample or the second sample and the reagent until the mechanism for processing the second sample reaches the blank period.
  • the arm-shaped transfer mechanism is configured to wait for the second sample to wait on the standby table in accordance with a timing when the mechanism for processing the second sample reaches the blank period.
  • the reaction solution of the second specimen and the reagent is transferred to a mechanism for processing the second specimen.
  • the analyzer according to the present invention is characterized in that the transfer mechanism is a table-like transfer mechanism that stores a liquid and transfers it to a predetermined position at a predetermined timing.
  • the processing for the first sample is performed between the processing timing for the predetermined first sample and the processing timing for the first sample to be processed next to the predetermined first sample. If there is a blank period and the analysis of the second sample is necessary, each process for the first sample is overtaken and the second sample is processed during the blank period. Even if analysis processing is performed on the first sample, analysis processing can be quickly performed on the second sample for which an urgent result is to be obtained.
  • FIG. 1 is a schematic diagram showing a configuration of an analyzer according to an embodiment.
  • FIG. 2 is a diagram for explaining measurement instructions, measurement start, and measurement processing timing for each specimen in the analyzer shown in FIG. 1.
  • FIG. 2 is a diagram for explaining measurement instructions, measurement start, and measurement processing timing for each specimen in the analyzer shown in FIG. 1.
  • FIG. 3 is a diagram for explaining the measurement instruction, the start of measurement, and the timing of the measurement process for each sample in the analyzer that is effective in the prior art.
  • FIG. 4 is a diagram for explaining the measurement instruction, the start of measurement, and other timing of the measurement process for each sample in the analyzer diagram shown in FIG.
  • FIG. 5 is a flowchart showing blank cycle generation processing of the timing control unit shown in FIG.
  • FIG. 6 is a schematic diagram showing a configuration of an analyzer that works on the example.
  • FIG. 7 is a diagram for explaining an analysis process in the analyzer shown in FIG.
  • FIG. 8 is a diagram for explaining the operation of the sample transport section, the sample dispensing transport mechanism, and the BF table shown in FIG.
  • FIG. 9 is a diagram for explaining a specimen processed in each step shown in FIG. 7 in each cycle.
  • FIG. 10 is a diagram for explaining operations of the immune reaction table, the BF table, and the first cuvette transfer mechanism shown in FIG. 6.
  • FIG. 11 is a diagram for explaining operations of the immune reaction table, the BF table, and the first cuvette transfer mechanism shown in FIG. 6.
  • FIG. 12 is a diagram for explaining the operation of the BF table shown in FIG.
  • FIG. 13 is a diagram for explaining the operation of the BF table shown in FIG.
  • FIG. 14 is a diagram for explaining the operation of the BF table shown in FIG.
  • FIG. 15 is a diagram for explaining a mixed mode in the analyzer shown in FIG. 6.
  • FIG. 16 is a diagram for explaining a normal mode in the analyzer shown in FIG. Explanation of symbols
  • an analysis apparatus performs an immunological test such as an antigen-antibody reaction of a test blood in each field such as a biochemical test and a blood transfusion test.
  • An analysis apparatus will be described as an example. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.
  • Fig. 1 shows the configuration of the analyzer that works on this example. It is a schematic diagram.
  • the analyzer 1 according to the embodiment includes a measuring mechanism 2 that optically measures a reaction occurring between a specimen and a reagent, and an analyzer 1 including the measuring mechanism 2 that controls the entire apparatus. And a control mechanism 4 for analyzing the measurement results in the measurement mechanism 2.
  • the analyzer 1 automatically performs immunological analysis of a plurality of specimens through the cooperation of these two mechanisms. For example, analyzer 1 has many analysis processes and a long analysis time. V ⁇ Analyze sample A for which inspection item a is indicated, and analysis B for analysis item B that has few analysis steps and analysis time is short! Processing is performed at the same time.
  • the measurement mechanism 2 includes a sample and reagent dispensing process to a reaction container transferred to each mechanism for performing each process, a stirring process, a reaction process in which a sample and a reagent are reacted in the reaction container, After removing the unreacted substance in the reaction vessel, the reaction solution in which the sample and reagent have reacted is optically measured. When the optical measurement is complete, the reaction vessel is discarded.
  • the control mechanism 4 is realized by using one or a plurality of computer systems, and is connected to the measurement mechanism 2 that optically measures the reaction in the reaction vessel.
  • the control mechanism 4 controls the operation process of the measurement mechanism 2 and analyzes the measurement result in the measurement mechanism 2 using various software related to each process of the analyzer 1.
  • the control mechanism 4 includes a control unit 41, an input unit 43, an analysis unit 44, a storage unit 45, an output unit 46, and a transmission / reception unit 47. These units included in the measurement mechanism 2 and the control mechanism 4 are electrically connected to the control unit 41.
  • the control unit 41 is configured using a CPU or the like having a control function, and controls processing and operation of each component of the analyzer 1.
  • the control unit 41 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information.
  • the control unit 41 controls the analyzer 1 by reading out the program stored in the storage unit 45 from the memory.
  • the control unit 41 has a timing control unit 42.
  • the input unit 43 is configured by using a keyboard for inputting various information, a mouse for designating an arbitrary position on the display screen of the output unit 46, and the like. Necessary information and analysis operation instruction information from outside.
  • the storage unit 45 includes a hard disk that magnetically stores information, and the analysis apparatus 1 executes processing. In this case, it is configured by using a memory that loads various programs related to the processing from the node disk and electrically stores them, and stores various information including analysis results of the specimen.
  • the storage unit 45 may include an auxiliary storage device that can read information stored in a storage medium such as a CD-ROM, DVD-ROM, or PC card.
  • the output unit 46 is configured by using a display, a printer, a speaker, and the like, and outputs various information related to analysis.
  • the transmission / reception unit 47 has a function as an interface for performing transmission / reception of information according to a predetermined format via a communication network (not shown).
  • the timing control unit 42 controls the processing timing of each mechanism of the measuring mechanism 2 constituting the analyzer in accordance with the analysis content.
  • the timing control unit 42 provides a blank period during which the sample A is not processed between the processing timing for the predetermined sample A and the processing timing for the sample A to be processed next to the predetermined sample A. If analysis is necessary, add each process to specimen A, and then process specimen B during the blank period.
  • the timing control unit 42 controls the processing timing for the sample A in each mechanism constituting the measurement mechanism 2 to generate a blank period.
  • the timing control unit 42 delays the analysis start timing for the specimen A to be processed next to the predetermined specimen A to generate a blank period.
  • the timing control unit 42 overtakes the sample A at a timing when the mechanism for processing the sample B reaches the blank period with respect to the transfer mechanism in the measurement mechanism 2 that transfers the liquid or the reaction container containing the liquid. Then, control is performed so that the sample B or the reaction solution of the sample B and the reagent is transferred to the mechanism for processing the sample B.
  • FIG. 2 is a diagram for explaining the timing of measurement instruction, measurement start, and measurement processing for each specimen.
  • the cycle in FIG. 2 is a time unit that serves as a reference for the processing operation in each mechanism of the measurement mechanism 2, and the optical measurement process in the measurement mechanism 2 is performed once per cycle.
  • the test item b of the analysis cycle is shorter than the test item a for the samples A1 to A7.
  • the inspection item “a” to be measured is instructed at the eighth cycle after the start of measurement.
  • sample B1 The inspection item b to be measured in the second cycle from the scheduled start is instructed.
  • the measurement instructions are given to the sample B1 at the eighth cycle.
  • the processing table has a plurality of cuvette storage chambers that can each store a plurality of cuvettes.
  • the processing table is rotated to move the cuvette storage chamber corresponding to the sample instructed to start measurement to the cuvette transfer position where the cuvette transfer means transfers the cuvette.
  • the processing table rotates, for example, every cycle, and each cuvette storage chamber is transferred to the cuvette transfer position in the order of arrangement.
  • the timing control unit 42 generates blank cycles Bsl to Bs6 between the processing timings of the samples A1 to A7 in the cuvette placement process.
  • the blank cycles Bsl to Bs6 are generated at predetermined intervals by controlling the cuvette arrangement timing for the specimens A1 to A7. In the column R2 in FIG. 2, one of the two cycles is controlled as the processing timing of the samples A1 to A7, and blank cycles Bsl to Bs6 are generated in the remaining one cycle.
  • the timing control unit 42 performs the placement process on the cuvette processing table to which the specimen A1 is dispensed in the second cycle, and measures the specimen A1.
  • cuvette processing in which sample A2 is dispensed in the 4th cycle instead of the 3rd cycle. Placement on the table starts the measurement of sample A2, and a blank cycle Bsl is generated in the 3rd cycle.
  • the cuvette is placed between the cuvette storage chamber in which the cuvette for dispensing the sample A1 is arranged and the cuvette storage chamber in which the cuvette for dispensing the sample A2 is arranged. An empty cuvette storage room will be located.
  • the measurement is started by performing the cuvette placement process in which the sample A3 is dispensed in the 6th cycle instead of the 5th cycle. Generates a blank cycle Bs2. Then, for sample A4, the cuvette placement process in which sample A4 is dispensed in the 8th cycle is performed and measurement is started, and a blank cycle Bs3 is generated in the 7th cycle, and 10% for sample A5. cycle The cuvette where sample A5 is dispensed into the eye is placed and measurement is started, and blank cycle Bs4 is generated at the ninth cycle. In this case, in each mechanism, the cycle for processing the specimens A1 to A7 and the blank cycle alternate.
  • the cuvette storage chamber where the cuvettes into which the specimens A1 to A7 are dispensed and the empty cuvette storage chamber where no cuvette is arranged are alternately positioned. It becomes.
  • Each mechanism can process samples other than samples A1 to A7 during a blank cycle in which processing is not performed on samples A1 to A7.
  • the measurement start process for the sample A7 is overtaken by the measurement start cycle for the sample A7 as shown by the arrow Ya in the 15th cycle after the 14th cycle.
  • Sample B1 is dispensed during the blank cycle Bs4 generated in the eye.
  • the cuvette placement process is performed, and the measurement is started.
  • the cuvette in which the sample B1 is dispensed is dispensed in the 9th blank cycle Bs4.
  • the cuvette is placed in the empty cuvette storage chamber that is the next cuvette storage chamber after the cuvette storage chamber in which the cuvette is arranged. In this way, the measurement start process for specimen B1 passes the measurement start process for specimens A5 to A7 and interrupts at the blank cycle Bs4. Done.
  • Samples A2 to A7 are measured in the 12th, 14th, 16th, 18th, 20th, and 22nd cycles with blank cycles Bsl to Bs6 in between.
  • the sample B1! / And the sample A2 to the sample A4 are added to the measurement process, and the measurement instruction process is performed as indicated by the arrow Yb.
  • the measurement process is performed during the blank cycle Bsl of the 11th cycle after passing through. In this way, the measurement process for specimen B1 is performed in the shortest analysis time with the measurement instructed by overtaking the measurement process for specimens A2-A4 and interrupting at blank cycle Bsl.
  • Figure 3 shows the conventional analyzer.
  • the cuvettes into which the samples A1 to A7 and the sample B1 are dispensed are sequentially arranged on the processing table in the order of B1, and measurement is started.
  • the sample B1 can be measured at the 11th cycle after 2 cycles from the 9th cycle when the measurement start process was performed as indicated by the arrow Yc.
  • the measurement process cannot be performed because the measurement process for sample A3 that received the measurement start instruction first is performed in the 11th cycle and is duplicated. Since the measurement process for samples A1 to A7 continues, in order for sample B1 to receive the measurement process, as shown by the arrow Yd, it is necessary to wait until the 16th cycle when all the measurement processes for sample A1 to A7 are completed. was there. Furthermore, the samples A1 to A7 have a longer waiting time for the sample B1 as the number of samples for which a measurement start instruction is given earlier than the time from the start of measurement to the end of measurement increases. Therefore, the analysis result of the specimen B1 that can be obtained in a short time cannot be obtained quickly.
  • specimen B1 which is often an emergency specimen for which results are urgently obtained, is the specimen B1 that is an emergency specimen in the past. The analysis results could not be obtained quickly, which could be an obstacle in the emergency medical field.
  • the analyzer 1 according to the present embodiment is provided between the processing timings of the samples A1 to A7 even when the analysis processing for the samples A1 to A7 is performed first. By interrupting each processing for the sample B1 in the blank cycle Bsl to Bs6, it becomes possible to quickly perform the analysis processing of the sample B1 for which the result is urgently obtained.
  • the force described when one of the two cycles is set as a blank cycle is not limited to this.
  • the timing control unit 42 generates a blank cycle by delaying the measurement start timing for the specimens A1 to A7.
  • the measurement of the specimen A3 is started in the fifth cycle and the fourth cycle.
  • Has a blank cycle Btl After starting the measurement of specimen A4 in the 6th cycle, 8 cycles The sample A5 measurement is started in the eye, and a blank cycle Bt2 is provided in the seventh cycle.
  • measurement of sample A7 is started in the 11th cycle, and a blank cycle Bt3 is provided.
  • the measurement start of the sample A7 is overtaken in the 12th cycle following the 11th cycle in which the measurement start of the sample A7 is instructed.
  • the measurement is started by interrupting the blank cycle Bt3 generated in the 10th cycle.
  • the measurement process for specimen A1 is performed in the 10th cycle after the second cycle force is also 8th cycle, and the measurement process for specimen A2 is performed in the 11th cycle.
  • the measurement process for specimen B1 overtakes the measurement process for specimens A3 to A6, and during the blank cycle Btl of the twelfth cycle after the second cycle from the tenth cycle when the measurement instruction process was performed as shown by arrow Yb2 It is done by interrupting.
  • the sample for which the analysis result should be acquired quickly can be completed so that the measurement process can be completed earliest.
  • a white cycle may be provided in a timely manner.
  • FIG. 2 a case where a blank cycle is generated in the cuvette placement process in which each cuvette to which each specimen is dispensed is placed on the processing table has been described as an example. In other processes such as the process, agitation process, removal process, and reaction process, it is sufficient to control the process timing for specimens A1 to A7 to generate a blank cycle.
  • each processing timing and blank cycle insertion timing are determined so that the same processing does not overlap when any analysis item overlaps.
  • the timing control unit 42 considers both the processing capability of the apparatus and the urgency of obtaining the results for each specimen based on a plurality of preset patterns, and each processing timing and blank cycle in each mechanism. If you set the insertion timing of.
  • the timing control unit 42 receives analysis instruction information for instructing the start of analysis of a predetermined sample input from the input unit 43 (step S2). Based on the received analysis instruction information, the timing control unit 42 determines whether or not inspection items having different analysis times overlap (step S4). Timing control unit 42 If it is determined that test items with different times do not overlap (step S4: No), do not insert blank cycles! /, Control each component of measurement mechanism 2 at the processing timing, and End the insertion process.
  • step S4 determines whether or not it is possible to perform additional processing for a sample that needs to be analyzed quickly, such as an emergency sample. Is determined based on the instruction information input from the input unit 43 (step S6). If the timing control unit 42 determines that the overtaking process should not be executed (step S6: No), the blank cycle insertion process is not performed! The control unit 42 controls each component of the measurement mechanism 2 at the processing timing, and the blank cycle is performed. End the insertion process.
  • step S6 determines to execute an additional process
  • step S6 determines to execute an additional process
  • the timing control unit 42 determines to execute an additional process (step S6: Yes)
  • the storage unit 45 includes each blank cycle insertion timing pattern illustrated in FIGS. 2 and 4 and one or more blank cycle insertion timing patterns most suitable for each combination of overlapping inspection items. Memorize the corresponding table.
  • the timing control unit 42 may search the insertion timing pattern of the blank timing most suitable for the duplicate inspection item by referring to this table.
  • the output unit 46 presents the insertion timing pattern searched by the timing control unit 42 (step S10). Specifically, the output unit 46 displays a menu including an insertion timing pattern searched by the timing control unit 42 and a permission column that permits the insertion timing pattern and a non-permission column that does not permit the insertion timing pattern. Display output.
  • the timing control unit 42 determines whether the insertion timing pattern presented by the output unit 46 is OK / NO (step S12). ). Specifically, the operator of the analyzer checks this menu, and when permitting the presented insertion timing pattern, operates the mouse or keyboard to select the permission column. In this case, an instruction to allow the presented insertion timing pattern from the input unit 43. Since the information is input, the timing control unit 42 determines that the insertion timing pattern presented by the output unit 46 is acceptable (step S12: Yes), and sets this insertion timing pattern as the blank timing insertion timing. (Step S14), according to the insertion timing pattern, each component is controlled so as to generate a blank timing.
  • the operator of the analyzer checks this menu, and if the inserted insertion timing pattern is not permitted, operates the mouse or keyboard to select the non-permitted column. In this case, since the instruction information not permitting the presented insertion timing pattern is input from the input unit 43, the timing control unit 42 determines that the insertion timing pattern presented by the output unit 46 is not suitable ( Step S12: No), return to Step S8, and search for the insertion timing pattern again.
  • the timing control unit 42 performs analysis from the generation timing patterns of the blank period corresponding to the analysis time for each first sample and the analysis time for each second sample obtained in advance.
  • a blank cycle generation timing pattern corresponding to the first sample and the second sample to be performed may be selected, and a blank cycle may be generated according to the selected blank period generation timing pattern.
  • the test item a is performed for a plurality of samples A1 to A7, and the test item b is performed for sample B1.
  • 1S explained in a nutshell it is not limited to this.
  • the processing corresponding to the test item b of the sample B1 may be performed by overtaking each processing on the sample A.
  • the analysis process corresponding to the inspection item for which the result is to be obtained quickly can be performed in the blank cycle by overtaking the analysis process for other inspection items, so that the analysis of inspection items with different analysis times is duplicated. Applicable when
  • the measurement mechanism 2 in the analyzer 1 will be described in detail with reference to FIG.
  • the measurement mechanism 2 is roughly divided into a sample transfer unit 21, a chip storage unit 22, a sample dispensing transfer mechanism 23, an immune reaction table 24, a BF table 25, a first reagent storage unit 26, and a second reagent.
  • Storage unit 27 first reagent dispensing mechanism 28, second reagent dispensing mechanism 29, enzyme reaction table 30, photometric mechanism 31, first cuvette transport mechanism 32, second cuvette transport mechanism 33 and Standby table 34.
  • the sample transfer unit 21 includes a plurality of sample racks 21b that hold a plurality of sample containers 21a containing samples and are sequentially transferred in the direction of the arrows in the figure.
  • the specimen stored in the specimen container 21a is blood or urine collected by the donor's power.
  • the sample transport unit 21 is provided with a normal lane 21c for transporting samples that are not urgent and processed normally, and an extra lane 21d for transporting emergency samples that require urgent analysis results. RU
  • the chip storage unit 22 is provided with a chip case in which a plurality of chips are aligned, and this case force chip is supplied.
  • This tip is a Disposable Nopple Sampnore chip that is attached to the tip of the nozzle of the sample dispensing transfer mechanism 23 to prevent carryover when measuring infectious disease items, and is exchanged for each sample dispensing.
  • the specimen dispensing / transfer mechanism 23 is configured to rotate around a vertical line whose center axis is a probe that sucks and discharges a specimen, is attached to the distal end, moves up and down in the vertical direction, and passes through its proximal end. It has an arm that can be used freely.
  • the sample dispensing transfer mechanism 23 sucks the sample in the sample container 21a moved to the predetermined position by the sample transfer unit 21 with the probe, rotates the arm, and dispenses it to the cuvette transported to the predetermined position by the BF table 25. Then, the sample is transferred into the cuvette on the BF table 25 at a predetermined timing.
  • the immune reaction table 24 has a reaction line for reacting a specimen with a predetermined reagent corresponding to an analysis item in each cuvette arranged.
  • the immune reaction table 24 is rotatable for each reaction line with a vertical line passing through the center of the immune reaction table 24 as a rotation axis, and transfers the cuvette arranged on the immune reaction table 24 to a predetermined position at a predetermined timing.
  • the peripheral line 24a for pretreatment and pre-dilution, the middle peripheral line 24b for immune reaction between the specimen and the solid phase carrier reagent, and the specimen and labeling reagent Form a triple reaction line structure with the inner peripheral line 24c for the immune reaction.
  • the BF table 25 performs BF (bound-free) separation for separating unreacted substances in the specimen or reagent.
  • the BF table 25 is rotatable for each reaction line with a vertical line passing through the center of the BF table 25 as a rotation axis, and transfers the cuvette arranged on the BF table 25 to a predetermined position at a predetermined timing.
  • BF Table 25 is a magnet required for BF separation. It has a magnetic flux collecting mechanism that collects the particle carrier, a BF cleaning nozzle that performs BF separation, and a stirring mechanism that disperses the magnetic carrier.
  • the first reagent storage unit 26 can store a plurality of reagent containers storing the first reagent to be dispensed into the cuvettes arranged on the BF table 25.
  • the second reagent storage unit 27 can store a plurality of reagent containers containing second reagents to be dispensed in the cuvettes arranged on the BF table 25.
  • the first reagent storage unit 26 and the second reagent storage unit 27 can be rotated clockwise or counterclockwise by driving a drive mechanism (not shown), and a desired reagent container can be dispensed and transferred to the first reagent. Transfer to reagent aspiration position by mechanism 28 or second reagent dispensing transfer mechanism 29.
  • the first reagent dispensing transfer mechanism 28 has a probe for aspirating and discharging the first reagent attached to the distal end portion, the vertical line passing through the base end portion of the first reagent ascending and descending in the vertical direction. It has an arm that can rotate freely.
  • the first reagent dispensing transfer mechanism 28 sucks the reagent in the reagent container moved to the predetermined position by the first reagent storage unit 26 with the probe, rotates the arm, and is conveyed to the predetermined position by the BF table 25. Dispense into cuvettes.
  • the second reagent dispensing transfer mechanism 29 has the same configuration as the first reagent dispensing transfer mechanism 28, and the reagent in the reagent container moved to a predetermined position by the second reagent storage unit 27 is sucked by the probe. Then, the arm is swung and dispensed into the cuvette transported to a predetermined position by the BF table 25.
  • the enzyme reaction table 30 is a reaction line for performing an enzyme reaction that generates light in a cuvette into which a substrate solution has been injected.
  • the photometric mechanism 31 measures luminescence emitted from the reaction solution in the cuvette.
  • the photometric mechanism 31 includes, for example, a photomultiplier tube that detects weak luminescence generated by chemiluminescence, and measures the amount of luminescence.
  • the photometry mechanism 31 holds an optical filter, and calculates the true light emission intensity based on the measured value reduced by the optical filter according to the light emission intensity.
  • the first cuvette transfer mechanism 32 freely moves up and down in the vertical direction and rotates around the vertical line passing through its proximal end, and immunizes the cuvette containing the liquid at a predetermined timing.
  • An arm for feeding is provided.
  • the second cuvette transfer mechanism 33 freely moves up and down in the vertical direction and rotates around the vertical line passing through the base end of the second cuvette, and the cuvette containing the liquid is moved at a predetermined timing.
  • An enzyme reaction table 30, a photometric mechanism 31, and an arm for transferring to a predetermined position of a cuvette disposal unit (not shown) are provided.
  • the standby table 34 is used until the mechanism for processing a predetermined emergency sample reaches the above-described blank cycle, the predetermined sample, the sample and a predetermined reagent, a cuvette containing the predetermined sample, or Then, wait for the cuvette containing the reaction liquid of this sample and the predetermined reagent.
  • the cuvette supply unit force (not shown) is also transferred by the first cuvette transfer mechanism 32 to the predetermined position of the BF table 25, and then the first reagent dispensing transfer mechanism 28 A first reagent dispensing process is performed in which the magnetic particle solid phase carrier reagent as the first reagent is dispensed (step S22). Thereafter, the sample container 21a containing the sample A is transferred by the sample transfer unit 21, and the BF table 25 is transferred from the sample container 21a by the sample dispensing transfer mechanism 23 to which the chip supplied from the chip storage unit 22 is attached.
  • Sample A is dispensed into the upper cuvette (step S23).
  • the cuvette is stirred by the stirring mechanism of the BF table 25 (step S25), and then transferred to a predetermined position of the immune reaction table 24 by the first cuvette transfer mechanism 32 to perform the first reaction. (Step S26).
  • the cuvette is transferred to the BF table 25 by the first cuvette transfer mechanism 32, and the magnetic particle carrier is collected by the magnetic collection mechanism in the BF table 25.
  • the first BF cleaning is performed by the cleaning nozzle (step S27).
  • the labeled reagent as the second reagent is dispensed into the cuvette after the BF separation by the second reagent dispensing transfer mechanism 29 (step S28), and stirred by the stirring mechanism.
  • the cuvette is transferred to a predetermined line of the immune reaction table 24 by the first cuvette transfer mechanism 32 and the second reaction is performed (step S29).
  • this cuvette is transferred to the BF table 25, the magnetic particle carrier is collected by the magnetic collection mechanism, and the second BF cleaning is performed by the BF cleaning nozzle (step S30). ) .
  • the substrate solution is injected into this cuvette (step S31) and stirred again.
  • the cuvette is transferred to the enzyme reaction table 30 by the first cuvette transfer mechanism 32, and the enzyme reaction is performed (step S32).
  • the second cuvette transfer mechanism 33 transfers this cuvette to the photometry mechanism 31, and the photometry mechanism 31 measures the light emitted from the cuvette to measure the control mechanism. Output the measurement result to 4 (step S33).
  • the analysis process for specimen B is different from specimen A after the first reagent dispensing process (step S22) and the specimen dispensing process (step S23) as in specimen A.
  • the second reagent dispensing process (step S24) is performed.
  • sample B the same procedure as for sample A, after stirring (step S25), first reaction (step S26), and first BF washing (step S27), the second reagent dispensing process (step S28), the second reaction process (step S29) and the second BF washing process (step S30) are deleted, and the process proceeds to step S31.Substrate injection process (step S31), enzyme reaction process (step S32), and measurement process (step S33) is performed.
  • a blank cycle is generated by controlling the processing timing of the first reagent dispensing process.
  • the timing controller 42 analyzes the samples A1 to A7 by delaying the processing timing of the first reagent dispensing process (step S22) in FIG.
  • a blank cycle is provided by delaying the start timing.
  • a cuvette corresponding to the sample A1 is arranged at P1, and the first reagent is dispensed.
  • a cuvette corresponding to specimen A2 is placed in P3 and the first reagent is dispensed
  • a cuvette corresponding to specimen A3 is placed in P5 and the first reagent is dispensed
  • P7 corresponds to specimen A4 Cuvette
  • the first reagent is dispensed
  • a cuvette corresponding to specimen A5 is placed on P9 and the first reagent is dispensed.
  • FIG. 9 is a diagram for explaining a sample processed in each step during each cycle.
  • cycle n and cycle (n + 1) as shown in FIG. 9, the stirring process in step S25, the first reaction process in step S26, and the first BF washing process in step S27 shown in FIG. Bl, A5 is performed in order.
  • the substrate injection process in step S31 is performed in the specimen B1, unlike the specimens A4 and A5, the second reagent dispensing process, the second reaction process, and the second BF washing process shown in step S28 to step S30 are omitted, and the substrate injection process in step S31 is performed.
  • the substrate injection process (step S31) for sample A3 is performed, so the sample The substrate injection process for B1 cannot be performed.
  • the first cuvette transfer mechanism 32 sets the cuvette containing the sample A4 to BF to perform the second reaction process (step S29).
  • the position force of P13 on the table 25 is also transferred to a predetermined position on the immune reaction table 24, and the cuvette containing the specimen B1 is transferred from the position P14 on the BF table 25 to the standby table 34 as indicated by the arrow Yh. .
  • the cuvette containing the sample B 1 stands by at the waiting table 34 during the cycle (n + 2).
  • the first cuvette transfer mechanism 32 moves the cuvette containing the specimen B1 from the standby table 34 to the PI 1 position of the BF table 25 as shown by the arrow Yi in FIG. Transport. Then, the BF table 25 transfers the cuvette containing the sample B1 to a predetermined substrate injection location, and performs the substrate injection process on the sample B1.
  • the first cuvette transfer mechanism 32 transfers the cuvette containing the specimen A4 to P12 of the BF table 25 as well as the immune reaction table 24 force.
  • the BF table 25 performs the second BF cleaning process (Step S30) on the specimen A4.
  • the first cuvette transfer mechanism 32 is configured so that the processing mechanism for processing the sample B1 next is a blank cycle so as not to overlap with the processing of the other samples Al to A7.
  • the cuvette containing the sample B1 is transferred to the standby table 34, and the cuvette containing the sample B1 is put on standby.
  • the first cuvette transfer mechanism 32 then moves the cuvette containing the sample B 1 waiting in the waiting table 34 to the next sample in accordance with the timing when the processing mechanism that processes the sample B1 next reaches the blank cycle.
  • B 1 Transfer to processing mechanism for processing.
  • the analyzer 1 can quickly perform the process on the sample B1 by overtaking the process on the samples A1 to A7.
  • the analyzer 1 may control the rotation processing of each table to process the sample B1 in addition to the processing of the samples A1 to A7! /.
  • the substrate injection process (step S31) of FIG. 7 a case where the substrate solution is injected at the Pk position of the BF table 25 shown in FIG. 12 will be described as an example.
  • the cuvettes are arranged in the order of samples A3, A4, Bl, and A5.
  • the cuvette containing the specimen A3 is transferred to the Pk position by the rotation of the BF table 25 as shown by the arrow Yk in FIG. It is transferred to the enzyme reaction table 30 by the cuvette transfer mechanism 32.
  • the cuvette containing the specimen B1 is moved to the Pk position by the rotation of the BF table 25 as shown by the arrow Y1 in FIG. 13, and the substrate injection process is performed. Then, the cuvette containing the specimen B1 is transferred to the enzyme reaction table 30 by the first cuvette transfer mechanism 32. After that, the cuvette containing the specimen A4 is transferred to the Pk position as shown in Fig. 14, and the substrate is injected. Processing is performed. As described above, the timing control unit 42 can perform processing on the sample B 1 by overtaking the processing on the samples A1 to A7 by controlling the rotation processing of each table such as the BF table 25.
  • a mixed mode shown in FIG. 15 is provided, in which a blank cycle is provided between the sample A groups to perform the overtaking process on the sample B 1 illustrated by the arrow Ym; Any deviation from the normal mode shown in Fig. 16 in which processing is performed sequentially without providing a blank cycle may be selected.
  • the normal mode shown in FIG. 16 is normally set.
  • the mixed mode shown in FIG. Analysis results can be acquired quickly. If Analyzer 1 is installed in a medical institution, Analyzer 1 performs the analysis process in the mixed mode during the period specified by this medical institution on the emergency reception date, and in other periods. May perform analysis processing in the normal mode.
  • the analysis apparatus described in the above embodiment can be realized by executing a prepared program on a computer system such as a personal computer or a workstation.
  • This computer system realizes the processing operation of the analyzer by reading and executing a program recorded in a predetermined recording medium.
  • the predetermined recording medium refers to “portable physical media” such as a flexible disk (FD), CD-ROM, MO disk, DVD disk, magneto-optical disk, and IC card, as well as inside and outside the computer system.
  • FD flexible disk
  • CD-ROM compact disc
  • MO disk Compact Disc
  • DVD disk digital versatile disk
  • magneto-optical disk magneto-optical disk
  • IC card magneto-optical disk
  • IC card integrated circuitry
  • any recording medium that records programs that can be read by a computer system such as a ⁇ communication medium '' that holds a program for a short time when sending a program, such as a hard disk drive (HDD) .
  • HDD hard disk drive
  • this computer system obtains
  • the analyzer according to the present invention separates samples with different analysis times. This is useful for medical analyzers that analyze samples, and in particular, medical analyzers that perform sample analysis processing that have obtained results urgently even when analysis processing is performed on other samples. 1 ⁇ then 0

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention porte sur un analyseur (1) d'analyse d'un premier spécimen, et d'un deuxième spécimen demandant un temps d'analyse différent de celui du premier spécimen, et caractérisé en ce qu'une une période blanche où n'a lieu aucun traitement sur le premier spécimen se trouve entre la période de traitement du premier spécimen et la période de traitement du deuxième spécimen, au cas où le deuxième spécimen doive être traité dans la période blanche avant le traitement du deuxième spécimen.
PCT/JP2006/321136 2006-10-24 2006-10-24 Analyseur WO2008050396A1 (fr)

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WO2010073504A1 (fr) * 2008-12-26 2010-07-01 株式会社 日立ハイテクノロジーズ Analyseur automatique
WO2010117045A1 (fr) * 2009-04-09 2010-10-14 株式会社日立ハイテクノロジーズ Auto-analyseur
JP2011033409A (ja) * 2009-07-30 2011-02-17 Hitachi High-Technologies Corp 自動分析装置
JP2012008053A (ja) * 2010-06-25 2012-01-12 Hitachi High-Technologies Corp 自動分析装置
WO2013084969A1 (fr) * 2011-12-09 2013-06-13 Canon Kabushiki Kaisha Appareil d'analyse pour test de laboratoire
JP2017201318A (ja) * 2015-03-31 2017-11-09 シスメックス株式会社 免疫測定装置および免疫測定方法
WO2019235158A1 (fr) * 2018-06-06 2019-12-12 株式会社日立ハイテクノロジーズ Dispositif d'analyse automatisé et procédé permettant de transporter un échantillon
WO2020149033A1 (fr) * 2019-01-18 2020-07-23 株式会社日立ハイテク Dispositif d'analyse automatique, système d'analyse automatique, et procédé d'analyse automatique pour analytes
CN112567249A (zh) * 2018-08-28 2021-03-26 株式会社日立高新技术 自动分析装置及其方法

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JPH0628736U (ja) * 1992-09-03 1994-04-15 日本テクトロン株式会社 試料容器ディスク装置
JP2003302408A (ja) * 2002-04-11 2003-10-24 Aloka Co Ltd 検体処理システム

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JPS63256859A (ja) * 1987-04-15 1988-10-24 Hitachi Ltd 自動分析装置
JPH0628736U (ja) * 1992-09-03 1994-04-15 日本テクトロン株式会社 試料容器ディスク装置
JP2003302408A (ja) * 2002-04-11 2003-10-24 Aloka Co Ltd 検体処理システム

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102265164B (zh) * 2008-12-26 2014-10-08 株式会社日立高新技术 自动分析装置
JP2010151710A (ja) * 2008-12-26 2010-07-08 Hitachi High-Technologies Corp 自動分析装置
WO2010073504A1 (fr) * 2008-12-26 2010-07-01 株式会社 日立ハイテクノロジーズ Analyseur automatique
CN102265164A (zh) * 2008-12-26 2011-11-30 株式会社日立高新技术 自动分析装置
JPWO2010117045A1 (ja) * 2009-04-09 2012-10-18 株式会社日立ハイテクノロジーズ 自動分析装置
WO2010117045A1 (fr) * 2009-04-09 2010-10-14 株式会社日立ハイテクノロジーズ Auto-analyseur
JP2011033409A (ja) * 2009-07-30 2011-02-17 Hitachi High-Technologies Corp 自動分析装置
JP2012008053A (ja) * 2010-06-25 2012-01-12 Hitachi High-Technologies Corp 自動分析装置
WO2013084969A1 (fr) * 2011-12-09 2013-06-13 Canon Kabushiki Kaisha Appareil d'analyse pour test de laboratoire
JP2017201318A (ja) * 2015-03-31 2017-11-09 シスメックス株式会社 免疫測定装置および免疫測定方法
JP2019211372A (ja) * 2018-06-06 2019-12-12 株式会社日立ハイテクノロジーズ 自動分析装置および試料の搬送方法
WO2019235158A1 (fr) * 2018-06-06 2019-12-12 株式会社日立ハイテクノロジーズ Dispositif d'analyse automatisé et procédé permettant de transporter un échantillon
JP7010768B2 (ja) 2018-06-06 2022-02-10 株式会社日立ハイテク 自動分析装置および試料の搬送方法
CN112567249A (zh) * 2018-08-28 2021-03-26 株式会社日立高新技术 自动分析装置及其方法
CN113272653A (zh) * 2019-01-18 2021-08-17 株式会社日立高新技术 自动分析装置、自动分析系统以及检体的自动分析方法
JPWO2020149033A1 (ja) * 2019-01-18 2021-10-07 株式会社日立ハイテク 自動分析装置および自動分析システム、ならびに検体の自動分析方法
WO2020149033A1 (fr) * 2019-01-18 2020-07-23 株式会社日立ハイテク Dispositif d'analyse automatique, système d'analyse automatique, et procédé d'analyse automatique pour analytes
JP7059403B2 (ja) 2019-01-18 2022-04-25 株式会社日立ハイテク 自動分析装置および自動分析システム、ならびに検体の自動分析方法
CN113272653B (zh) * 2019-01-18 2023-09-15 株式会社日立高新技术 自动分析装置、自动分析系统以及检体的自动分析方法

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