WO2008010985A2 - Phosphorus derivatives as histone deacetylase inhibitors - Google Patents
Phosphorus derivatives as histone deacetylase inhibitors Download PDFInfo
- Publication number
- WO2008010985A2 WO2008010985A2 PCT/US2007/016123 US2007016123W WO2008010985A2 WO 2008010985 A2 WO2008010985 A2 WO 2008010985A2 US 2007016123 W US2007016123 W US 2007016123W WO 2008010985 A2 WO2008010985 A2 WO 2008010985A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amino
- phenyl
- alkyl
- thienyl
- carbonyl
- Prior art date
Links
- 0 *OP1(OCC(CC2)(CCN2I)CO1)=O Chemical compound *OP1(OCC(CC2)(CCN2I)CO1)=O 0.000 description 14
- JPRRYPXPUYRBOW-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(C1SC=CC1)c1)c1NC(c(cc1)cnc1Cl)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(C1SC=CC1)c1)c1NC(c(cc1)cnc1Cl)=O)=O JPRRYPXPUYRBOW-UHFFFAOYSA-N 0.000 description 1
- ULMZPCPPDCDPOH-UHFFFAOYSA-N CC(CC1)CC1C(C1)C1C(C)(C)C Chemical compound CC(CC1)CC1C(C1)C1C(C)(C)C ULMZPCPPDCDPOH-UHFFFAOYSA-N 0.000 description 1
- CKLBJJNZZJNGCL-UHFFFAOYSA-N CC(CCC(CC1)(O)O)C1=N Chemical compound CC(CCC(CC1)(O)O)C1=N CKLBJJNZZJNGCL-UHFFFAOYSA-N 0.000 description 1
- AFWNMPPSZDFBIW-UHFFFAOYSA-N CCOP(Cc(nc1)ccc1C([O]1(C)CC1)=O)(OCC)=O Chemical compound CCOP(Cc(nc1)ccc1C([O]1(C)CC1)=O)(OCC)=O AFWNMPPSZDFBIW-UHFFFAOYSA-N 0.000 description 1
- VTOVRSMMCXHZNY-UHFFFAOYSA-N COP(C)(CC(CC1)=CC=C1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O Chemical compound COP(C)(CC(CC1)=CC=C1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O VTOVRSMMCXHZNY-UHFFFAOYSA-N 0.000 description 1
- GSTXVCMTWSHMPJ-UHFFFAOYSA-N COc(cc1)ccc1P(C=C)(C=C)=O Chemical compound COc(cc1)ccc1P(C=C)(C=C)=O GSTXVCMTWSHMPJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5304—Acyclic saturated phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002657288A CA2657288A1 (en) | 2006-07-20 | 2007-07-16 | Phosphorus derivatives as histone deacetylase inhibitors |
JP2009520791A JP2009544611A (ja) | 2006-07-20 | 2007-07-16 | ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 |
EP07810507A EP2049124A4 (en) | 2006-07-20 | 2007-07-16 | PHOSPHOR DERIVATIVES AS HISTONDEACETYLASE HEMMER |
US12/309,459 US7981874B2 (en) | 2006-07-20 | 2007-07-16 | Phosphorus derivatives as histone deacetylase inhibitors |
AU2007275743A AU2007275743A1 (en) | 2006-07-20 | 2007-07-16 | Phosphorus derivatives as histone deacetylase inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83201406P | 2006-07-20 | 2006-07-20 | |
US60/832,014 | 2006-07-20 | ||
US92054107P | 2007-03-28 | 2007-03-28 | |
US60/920,541 | 2007-03-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008010985A2 true WO2008010985A2 (en) | 2008-01-24 |
WO2008010985A3 WO2008010985A3 (en) | 2008-04-03 |
Family
ID=38957303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/016123 WO2008010985A2 (en) | 2006-07-20 | 2007-07-16 | Phosphorus derivatives as histone deacetylase inhibitors |
Country Status (6)
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2170076A1 (en) * | 2007-06-27 | 2010-04-07 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
US8168658B2 (en) | 2006-02-28 | 2012-05-01 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
US8420640B2 (en) | 2008-08-29 | 2013-04-16 | Treventis Corporation | Methods of treating amyloid disease using analogs of 1-(4-nitrophenyl) piperazine |
US8461189B2 (en) | 2007-06-27 | 2013-06-11 | Merck Sharp & Dohme Corp. | Pyridyl derivatives as histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
CZ305738B6 (cs) * | 2014-12-16 | 2016-02-24 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující |
CN105859774A (zh) * | 2016-04-12 | 2016-08-17 | 盘锦格林凯默科技有限公司 | 一种膦苯类化合物的制备方法 |
US9434994B2 (en) | 2004-05-27 | 2016-09-06 | The Regents Of The University Of Colorado, A Body Corporate | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by non-small cell lung cancer patients |
WO2016150215A1 (zh) * | 2015-03-24 | 2016-09-29 | 华南理工大学 | 离子型阴极缓冲层分子型材料及其制备方法和应用 |
US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US9908908B2 (en) | 2012-08-30 | 2018-03-06 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Tenofovir prodrug and pharmaceutical uses thereof |
US9951069B1 (en) | 2017-01-11 | 2018-04-24 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
US10029988B2 (en) | 2013-03-15 | 2018-07-24 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
EP3452489B1 (fr) * | 2016-05-02 | 2020-05-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Nouveaux dérivés de phosphinolactones et leurs utilisations pharmaceutiques |
US10919902B2 (en) | 2015-07-06 | 2021-02-16 | Alkermes, Inc. | Hetero-halo inhibitors of histone deacetylase |
CN112538091A (zh) * | 2020-11-26 | 2021-03-23 | 湖北大学 | 一种高纯度双-(对-羧基苯氨基)苯基氧化膦阻燃剂的合成法 |
USRE48547E1 (en) | 2010-08-23 | 2021-05-11 | Syntrix Biosystems Inc. | Aminopyrimidinecarboxamides as CXCR2 modulators |
US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
US11248013B2 (en) | 2011-05-31 | 2022-02-15 | Rakovina Therapeutics Inc. | Tricyclic inhibitors of poly(ADP-ribose)polymerase |
CN114685559A (zh) * | 2022-05-16 | 2022-07-01 | 多氟多新材料股份有限公司 | 一种双三氟甲基磷酸锂的制备方法 |
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WO2014018913A2 (en) * | 2012-07-27 | 2014-01-30 | University Of Connecticut | Santacruzamate a compositions and analogs and methods of use |
CN105307683A (zh) | 2013-03-14 | 2016-02-03 | 基因泰克公司 | 治疗癌症和预防癌症药物抗性的方法 |
US10807944B2 (en) | 2014-04-04 | 2020-10-20 | University Of Florida Research Foundation, Inc. | HDAC inhibitor compounds and methods of treatment |
WO2017127417A1 (en) * | 2016-01-19 | 2017-07-27 | Prospero Pharmaceuticals Llc | Phosphopantothenate compounds |
WO2024025862A1 (en) * | 2022-07-28 | 2024-02-01 | The Board Of Regents Of The University Of Oklahoma | Agonists of peroxisome proliferator-activated receptor alpha (ppara) and methods of use |
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NL294211A (US07981874-20110719-C00285.png) * | 1962-06-19 | |||
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US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
JP2787407B2 (ja) * | 1992-06-19 | 1998-08-20 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
JPH11335375A (ja) | 1998-05-20 | 1999-12-07 | Mitsui Chem Inc | ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体 |
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CN1777577B (zh) | 2003-01-08 | 2011-07-06 | 诺华疫苗和诊断公司 | 抗菌剂 |
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JP5319113B2 (ja) | 2004-03-26 | 2013-10-16 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
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-
2007
- 2007-07-16 EP EP07810507A patent/EP2049124A4/en not_active Withdrawn
- 2007-07-16 CA CA002657288A patent/CA2657288A1/en not_active Abandoned
- 2007-07-16 JP JP2009520791A patent/JP2009544611A/ja not_active Withdrawn
- 2007-07-16 WO PCT/US2007/016123 patent/WO2008010985A2/en active Application Filing
- 2007-07-16 US US12/309,459 patent/US7981874B2/en not_active Expired - Fee Related
- 2007-07-16 AU AU2007275743A patent/AU2007275743A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
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See references of EP2049124A4 * |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
US9434994B2 (en) | 2004-05-27 | 2016-09-06 | The Regents Of The University Of Colorado, A Body Corporate | Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by non-small cell lung cancer patients |
US8168658B2 (en) | 2006-02-28 | 2012-05-01 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
EP2170076A1 (en) * | 2007-06-27 | 2010-04-07 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
EP2170076A4 (en) * | 2007-06-27 | 2011-09-07 | Merck Sharp & Dohme | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONDEACETYLASE INHIBITORS |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US8461189B2 (en) | 2007-06-27 | 2013-06-11 | Merck Sharp & Dohme Corp. | Pyridyl derivatives as histone deacetylase inhibitors |
AU2008269154B2 (en) * | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US9096559B2 (en) | 2007-06-27 | 2015-08-04 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US8420640B2 (en) | 2008-08-29 | 2013-04-16 | Treventis Corporation | Methods of treating amyloid disease using analogs of 1-(4-nitrophenyl) piperazine |
US20160122290A1 (en) * | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
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CA2657288A1 (en) | 2008-01-24 |
US20090270351A1 (en) | 2009-10-29 |
US7981874B2 (en) | 2011-07-19 |
EP2049124A4 (en) | 2010-02-10 |
EP2049124A2 (en) | 2009-04-22 |
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AU2007275743A1 (en) | 2008-01-24 |
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