Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
  • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
  • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
  • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
  • G01S7/52023—Details of receivers
  • G01S7/52025—Details of receivers for pulse systems
  • G01S7/52026—Extracting wanted echo signals
  • G01S7/52028—Extracting wanted echo signals using digital techniques
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
  • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
  • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
  • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
  • G01S7/52046—Techniques for image enhancement involving transmitter or receiver
  • G01S7/52047—Techniques for image enhancement involving transmitter or receiver for elimination of side lobes or of grating lobes; for increasing resolving power
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
  • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
  • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
  • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
  • G01S7/52085—Details related to the ultrasound signal acquisition, e.g. scan sequences
  • G01S7/5209—Details related to the ultrasound signal acquisition, e.g. scan sequences using multibeam transmission
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
  • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
  • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
  • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
  • G01S7/52085—Details related to the ultrasound signal acquisition, e.g. scan sequences
  • G01S7/52095—Details related to the ultrasound signal acquisition, e.g. scan sequences using multiline receive beamforming

Definitions

• This invention relates to medical diagnostic ultrasound systems and, in particular, to ultrasound systems which extend the focal region using a multiline receive beamformer .
• a specific application which employs the basic principles of synthetic focusing is the traditional delay-and-sum receive beamformer, in which the delays applied to the signals from each receiving element are the equivalent of data selection in the synthetic focus technique.
• the traditional beamformer is a limited application of these principles as it transmits a transmit beam focused at a specific focal region and dynamically focuses echoes only along this single transmit beam. Multiple transmissions are thus required to scan the entire image field.
• a resulting efficiency is that data does not need to be stored for all transmissions to every point in the image; the data received from a transmission is immediately processed to form coherent echo signals along the beam direction.
• a limitation is that each received beam is focused on transmit to only the selected focal region.
• This approach is premised upon the assumption of a "virtual source element" at the focal point of a standard transmitted beam which radiates energy both outward and inward from this "virtual source.”
• energy is received by the transducer elements of the receive aperture and stored.
• an echo signal at each point is computed from the signals received by elements of each virtual source field which encompassed the point in the field.
• Image points at the focal point will be imaged from only one beam, as the virtual source model is an hourglass-shaped field about the transmit focal point, but points further removed in depth from the focal point are computed from the received signals of many scanlines.
• the result is said to be an image which shows improved lateral resolution at points outward and inward from the transmit focal point.
• a significant amount of data must be stored for processing, the r.f. signals from every element in each receive aperture.
• the resultant image is said to appear darker around the focal point, since only one transmission and reception contributes to this image point and its resolution, whereas multiple transmissions and receptions contribute to points removed from the transmit focal point. Accordingly it is desirable to effect transmit focusing over at least a significant portion of an image but without the need to store vast amounts of r.f. data.
• retrospective dynamic transmit focusing In this approach groups of multilines are acquired which overlap spatially so that several resulting multilines are spatially co-aligned and hence from the same receive location. Spatially aligned multilines are then combined with a weighting function, e.g., apodization, if desired, and an inter-multiline delay which is generally related to the location of transmit beam centers to the received multiline location, which prevents undesired phase cancellation in the combined signals. The weighted and delayed multilines are then combined to produce a resultant line for display.
• This technique is advantageous because it improves the depth of field of the image by combining multiple received signals, and the effective beamforming from the received multilines causes the combination of multilines to be effectively transmit focused over a considerable depth of field.
• retrospective dynamic transmit focusing the name retrospective dynamic transmit focusing.
• the RDT technique as described above is a coherent signal process, as it operates on signals as a function of both amplitude and phase characteristics.
• Ultrasonic imaging is a coherent process in vivo since the echoes reflected back to the transducer elements from reflectors in the body- will have their own amplitude and phase characteristics.
• a disadvantage of this coherent character is that the reflected signals will both constructively and destructively interfere with each other, producing a mottled pattern known as "speckle" which overlays the desired tissue image and detracts from the image contrast. Since the speckle pattern has no phase or amplitude variation over time, it cannot be suppressed simply by averaging the image signals over time.
• a diagnostic ultrasound system and method are described in which the RDT technique is performed incoherently, effecting both an extended transmit focus over a significant depth of field and a reduction of the speckle effect.
• this is done by nonlinearly processing the multiline signals (as by detection) prior to combining. Since the multilines from different transmit signals have slightly different transmit apertures, combining the multiline signals as detected rather than r.f. data will cause a compounding effect which reduces the speckle.
• FIGURES Ia-Ic illustrate beam profiles of a three-beam example of the present invention.
• FIGURES 2a-2d illustrate beam profiles of a six- beam example of the present invention.
• FIGURES 3a-3d illustrate a four-beam example of the present invention in which the first four beam patterns are offset for clarity of illustration.
• FIGURES 4a-4d illustrate a continuation of the four-beam example of FIGURE 3 showing the alignment of the receive beams.
• FIGURE 5 illustrates in block diagram form an ultrasound system constructed in accordance with the principles of the present invention.
• FIGURES 6a and ⁇ b illustrate the delay and weighting characteristics of two different beams of the four-beam example of the present invention.
• FIGURES Ia-Ic overlapping beam profiles are shown for the transmission of three transmit beams followed in each case by the reception of three beams from each transmit beam.
• FIGURE Ia shows the transmit beam profile 10 at a constant level below the intensity peak at the center of the beam, transmitted by and extending from a transducer array 8 that transmitted the beam.
• the transmit beam profile level is chosen by the designer and may be 3 dB, 6 dB, 20 dB, or some other level below the maximum intensity at the center of the beam.
• the beam profile is seen to be focused about a focal point 12 at the narrowest width of the beam profile by conventional transmit focusing.
• An orthogonal view of the beam 20 is shown below the transducer array 8 which is seen to comprise a center lobe 20a and side lobes on either side of the main lobe 20a.
• the transmitted beam reaches its tightest focus at the focal region 12 and diverges thereafter. In other implementations a diverging transmit beam may be used. Focusing at a considerable depth has also been found to be effective.
• the transmit beam 10, 20 is transmitted with a width that encompasses multiple receive lines 14, 16, and 18. Generally a wider beam is produced by transmitting from a smaller transmit aperture. That is, a lesser number of elements of the array 8 are actuated to transmit the beam than the total number of elements across the array. Following transmission echoes are received and focused along three receive line locations 14, 16 and 18. As discussed below, the echoes received by the transducer elements of the receive aperture are delayed and summed in three different ways to form multiple lines at different line locations 14, 16, and 18 in response to one transmit beam. In this example receive line 14 is received down the center of the transmit beam 10, 20 and receive lines 14 and 18 are laterally steered and focused to be received on either side of the center line.
• the outer lines 14 and 18 are within the transmit beam profile 10. In these regions the outer lines 14 and 18 are received from transmit energy on either side of the center line position thereby sampling targets in the image field on both sides of the center line position, thereby efficiently using the laterally spread energy of the transmit beam in the near and far fields for image reception and resolution.
• a second beam has been transmitted by shifting the transmit aperture to the right by the spacing of one receive line.
• the second transmit beam has the same beam profile as the first transmit beam and is outlined by beam profile curves 10'.
• three receive lines are simultaneously received and beamformed in response to the second transmission at receive line locations 16', 18' and 22.
• receive line 16' is aligned with receive line 16 from the first transmission
• receive line 18' is aligned with receive line 18 from the first transmission
• receive line 22 is located to the right of the center line 18' of the second transmission.
• the second set of receive multilines 16', 18', and 22 is saved for subsequent processing.
• FIGURE Ic a third beam has been transmitted from a center aperture location which is again shifted to the right by one receive line.
• This transmit beam is outlined by beam profile 10" and the transmission is followed by the simultaneous reception of three receive lines 18", 22' and 24.
• These three receive lines like the previous receive lines, are wholly or partially within the beam profile of their transmit beam with the same spacing as the lines of the preceding beams.
• receive line 18" is axially aligned with receive line 18' of the second transmission and receive line 18 of the first transmission
• receive line 22' is axially aligned with receive line 22 of the second transmission.
• the targets in the path of receive lines 18, 18' and 18" have now been sampled by three receive lines, each by a respectively different transmit beam.
• FIGURES 2a-2d give another example of the present invention in which the transmit beam profile 30 includes all or portions of receive lines at six receive line locations, identified at 31-36 in FIGURE 2a.
• the transmit beam profile 30 includes all or portions of receive lines at six receive line locations, identified at 31-36 in FIGURE 2a.
• central receive lines 33 and 34 are spaced one-half of a receive line spacing on either side of the center of the transmit beam.
• the outer receive lines 32 and 35 are within the beam profile 30 in the near and far fields, and only near field portions of the outermost receive lines 31 and 36 are within the transmit beam profile. It may be decided not to use these near field line portions 31 and 36 in image data formation as explained below.
• the next transmit beam is transmitted to the right of the first transmit beam by one receive line spacing as shown by the profile 30' of the second transmit beam in FIGURE 2b.
• Six receive lines are again received and beamformed simultaneously at receive line locations 32', 33', 34', 35', 36' and 37.
• the first five of these receive lines are seen to be aligned with receive lines 32, 33, 34, 35 and 36 of the first transmit beam, thus providing a second receive line for processing at each of these line locations.
• FIGURE 2c shows the results following transmission of a third transmit beam and reception of six receive lines within that beam profile 30". There now have been all or parts of three receive lines received at line locations 33", 34", 35" and 36", two receive lines at location 37', and a portion of one receive line at location 38.
• FIGURES 3 and 4 illustrate another example of the present invention using four receive lines from every transmit beam.
• the successive beam and receive line groups are not overlapping but are vertically aligned for clarity of illustration.
• Each transmit beam 40-1, 40-2, 40-3, etc. is indicated by a dashed arrow pointing downward, and the receive lines from each transmit beam are shown as solid line arrows on either side of the respective transmit beam.
• FIGURES 3a-3d illustrate the first four transmit-receive sequences, with the transmit beam 40-n being shifted to the right by one receive line spacing for each successive transmit interval.
• receive line 44 receive line 44-1 from the second beam
• receive line 44-2 receive line 44-2 from the third beam
• receive line 44-3 receive line 44-3 from the fourth beam.
• FIGURES 4a-4d show a continuation of the previous transmit-receive sequence with four more transmit-receive intervals of four simultaneously received lines for each transmit beam.
• the next four transmit beams are identified as 40-5, 40-6, 40-7, and 40-8 in these drawings.
• these drawings illustrate, there now have been four receive lines received at line locations 44, 45, 46, 47 and 48. After the four receive lines at each of these locations has been received the four lines can be combined to form one line of image data and the stored receive lines deleted so that subsequent lines can be stored in the same storage locations. Each time another fourth line of a group of four aligned lines has been received, the four lines of the group can be combined to form the line of image data at that location and the storage used for subsequent lines. The sequence continues in this manner, receiving four receive lines for each transmitted beam across the image field so that four receive lines may be combined at each line location over all but the lateral extremities of the image field.
• FIGURE 5 illustrates in block diagram form an ultrasonic imaging system constructed in accordance with the principles of the present invention.
• An ultrasonic probe 102 includes a transducer array 104 of transducer elements. Selected groups of the transducer elements are actuated at respectively delayed times by the transmit beamformer 106 to transmit beams focused at selected focal regions in the desired directions and from the desired origin (s) along the array.
• the transmit beamformer is coupled to the transducer elements by a transmit/receive switch which may comprise a crosspoint switch that protects the receiver inputs from the high voltage transmit pulses applied.
• the echoes received by each transducer element of the array 104 in response to each transmit beam are applied to the inputs of multiline processors llOa-llOn.
• Each multiline processor comprises a receive beamformer which applies its own set of delays and, if desired, apodization weights to weight the received echoes from the array elements to form a differently steered receive beam from the same transmit beam.
• Suitable multiline beamformers for the multiline processors HOa-IlOn may be found, for instance, in US Pat. 6,695,783 (Henderson et al . ) and US Pat. 5,318,033 (Savord) .
• the outputs of the multiline processors HOa-IlOn are coupled to a line store 112 which stores the received multilines at least until all of the multilines needed to form a line of display data have been acquired.
• the group of multilines used to form a particular line of display data are applied to respective ones of multipliers 116a-116n to produce the display data for the corresponding line location.
• the echo data from each line may, if desired be weighted by apodization weights 114a-114n. In general, these weights will weight each line as a function of its round-trip impulse response.
• the weight applied to this received multiline to form a point of the image at depth Z is:
• Weight (X, Z) amplitude (X, Z)
• X be the azimuth of the receive line with respect to the transmit beam axis.
• the delay applied to this received multiline to form a point of the image at depth Z is:
• Delay (X, Z) propagation_time (X, Z) -propagation_time (0,Z)
• propagation_time (0, Z) is the time to reach a point at the same depth but on-axis.
• the functions amplitude (X, Z) and propagation_time (X, Z) may, for example, be obtained from a simulation of the transmit field.
• An appropriate way to compute the propagation time is to use the phase delay of the field from monochromatic simulation at several frequencies.
• the amplitude may be computed by averaging the amplitude of the field at several frequencies.
• a depth-dependent normalization can be applied to the weights. This multiplies all the weights at a given depth by a common factor. For example, the normalization can be chosen so that speckle regions have uniform brightness with depth. By varying the weights as a function of depth, it is possible to vary the size and shape (apodization) of the aperture dynamically with depth.
• the amplitude and propagation time do not need to be derived from a simulation of the exact transmit characteristics used in the system.
• the designer may choose to use a different aperture size or a different apodization for example.
• the echoes from each line are weighted by the multipliers 116a-116n and delayed by delay lines 118a-118n.
• these delays will be related to the location of the transmit beam center to the receive line location as shown above.
• the delays are used to equalize the phase shift variance that exists from line to line for the multilines with differing transmit-receive beam location combinations, so that a loss of precision will not be caused by misalignment of the combined signals.
• the delay lines may be effected by storing the weighted multiline echo data in memory and reading the data out at later times which effect the necessary delay. Shift registers of differing lengths and clock signals may also be used to effect a digital delay, or an interpolating beamformer such as that described in the aforementioned US Pat. 6,695,783 may be used.
• the multiline signal are nonlinearly processed before being combined.
• this is accomplished by amplitude detection of the r.f. signals by detectors 130a-130n. Since each received multiline bears a slightly different relation to its transmit beam center than the other multilines in the combination, each multiline exhibits a slightly different speckle pattern. Detection removes the phase information from the signals so that the incoherent combining of the multilines will effect an averaging of the speckle characteristics, improving the desired signal to speckle noise ratio by approximately the square root of N, where N is the number of independent multilines being combined.
• the delayed and detected signals are combined by a summer 120 and the resultant signals are coupled to an image processor 122.
• the image processor may perform scan conversion or other processing to improve the displayed image.
• the resultant image is displayed on an image display 124.
• the combining of the respectively delayed multilines effect a refocusing of the signals received from the several receive multilines which are co-aligned in a given direction.
• the refocusing adjusts for the phase differences resulting from the use of different transmit beam locations for each multiline, effecting signal alignment in the combined signals.
• the detection enables the speckle patterns of the respective multilines to be averaged and reduced while causing but a small diminution from the loss of coherent refocusing.
• the weights 114 weight the contributions of the multilines in relation to the proximity of the transmit beam to the multiline location, giving higher weight to receive beams with higher signal-to-noise ratios. This results in an extended depth of field along each receive line and an enhanced penetration (improved signal-to-noise and signal-to-speckle-noise ratios) due to the combination of multiple samplings in each receive line direction.
• each received multiline is only used once in combination with other co-aligned multilines.
• each received multiline for a given line location is detected and then stored in a line accumulator for that line.
• Each subsequently received multiline at that line location is detected and then added to the contents of the accumulator until the full complement of multilines at that location has been combined in the accumulator.
• the accumulator contents are then forwarded to the image processor, freeing the accumulator for use for another line location.
• FIGURES 6a and 6b illustrate examples of the weighting and delay characteristics that may be used in combining the received multilines for a given display line location.
• FIGURE 6a illustrates example weighting and delay characteristics for a received multiline that is relatively distant from the transmit beam center such as received multiline 33' of FIGURE 2b.
• the center of the multiline is drawn as dotted where that portion of the multiline 33' is outside of the selected beam profile 30' and its response is below that which the designer has deemed to be acceptable.
• the weighting characteristic 82 thus weights this multiline with a weight which is at a minimum where it is beyond the beam profile and at nonzero levels where the multiline is to be used for refocusing.
• the weighting characteristic 82 may drop to zero in the near field. This is because the echoes may be too close to or behind the array after the necessary delay has been applied and thus not susceptible to accurate reception.
• the phase characteristic 84 is seen to cross through a zero phase adjustment at the focal point of the transmit beam, staying nearly constant in the near field and gradually decreasing in the far field.
• FIGURE ⁇ b illustrates exemplary weighting and delay characteristics for a received multiline 33 that is closer to the center of its transmit beam. Due to this closer proximity the multiline is given greater overall weighting in the combination as shown by the weighting characteristic 86. The weighting increases in the vicinity of the focal region to balance the falloff of the weighting of the more remote multilines such as 33' in this region.
• the phase adjustment characteristic 88 is drawn as a straight line because the delay characteristic 84 for the more laterally remote multiline is calculated from the phase of the more central multiline 33.
• the multiline 33 is used for refocusing over the full image depth, although in a given implementation the designer may elect to use the echoes of a single line from a transmit beam in close proximity to the line location in the very near field.
• An implementation of the present invention can be used with a variety of receive functions. For instance an implementation can operate on signals from focused sub-apertures.
• an implementation instead of forming receive beams per se, a limited number of orthogonal functions such as Fourier components can be used. It is then possible to combine the different transmits in Fourier space.
• the signals being combined do not correspond exactly to received image lines . Thereafter receive beams are formed by combining the Fourier components or sub-apertures. Various combinations of several beams and functions derived from a beam by a change of apodization are also within the scope of the present invention. In other implementations a small number of received multilines can be increased by interpolating additional intermediate multilines, then performing the inventive processing with the increased number of multilines.
• the summation process can be partitioned as illustrated in FIGURE 7.
• the delayed multiline data is combined in two partial summations referred to as Summation 1 and Summation 2.
• Each partial sum is then detected by a detector.
• the detected partial sums are then combined by Summation 3.
• An implementation with partial summation prior to detection requires fewer detectors.
• FIGURE 8 provides an example of an ultrasound system of the present invention in which the delays are partitioned with some of the delay applied to detected data.
• the coherent multiline data is delayed, then partially summed.
• the two partial sums are detected as in FIGURE 7, then a further delay is applied to the two detected partial sums before the final summation.
• the first delay stages can align the signals within each sub- aperture, then the second stages align the signals across the sub-apertures.
• Another variation of this implementation is to apply the second delay stages to the partial sums before detection. Variations of the examples above will readily occur to those skilled in the art and are within the scope of the present invention. For example, instead of transmitting along successive line locations, transmission can skip lines (multiplex) between multiline transmission.
• Transmission can be done along every other line position, every fourth line position, or other intervals of multi-line spacing, thus reducing the number of transmit events needed to form the image and increasing the acquisition rate. This is also a way to reduce motion artifacts.
• Receiving multilines at more widely spaced line intervals with a fewer number of transmit beams is another way to address the problem of motion.
• This approach can be augmented with interpolated lines as mentioned above to increase the number of lines which are combined. This will also increase the depth of field improvement for a given number of multilines.
• the sampling used is generally a function of the F number of the transmit aperture, which determines the Nyquist sampling requirement.
• 60/747148 is also applicable to implementations of the present invention.

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• 2007
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