WO2007072697A1 - Eau bactericide et procede et appareil pour la produire - Google Patents

Eau bactericide et procede et appareil pour la produire Download PDF

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Publication number
WO2007072697A1
WO2007072697A1 PCT/JP2006/324568 JP2006324568W WO2007072697A1 WO 2007072697 A1 WO2007072697 A1 WO 2007072697A1 JP 2006324568 W JP2006324568 W JP 2006324568W WO 2007072697 A1 WO2007072697 A1 WO 2007072697A1
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Prior art keywords
water
stock solution
dilution
hypochlorous acid
ppm
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PCT/JP2006/324568
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English (en)
Japanese (ja)
Inventor
Munenori Noguchi
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Noguchi Dental Medical Research Institute
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Priority to JP2007531527A priority Critical patent/JPWO2007072697A1/ja
Publication of WO2007072697A1 publication Critical patent/WO2007072697A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • C02F1/467—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction
    • C02F1/4672—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction by electrooxydation
    • C02F1/4674—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction by electrooxydation with halogen or compound of halogens, e.g. chlorine, bromine
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • C02F1/46104—Devices therefor; Their operating or servicing
    • C02F1/4618—Devices therefor; Their operating or servicing for producing "ionised" acidic or basic water
    • C02F2001/46185—Devices therefor; Their operating or servicing for producing "ionised" acidic or basic water only anodic or acidic water, e.g. for oxidizing or sterilizing
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/02—Non-contaminated water, e.g. for industrial water supply
    • C02F2103/026—Treating water for medical or cosmetic purposes
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/02—Non-contaminated water, e.g. for industrial water supply
    • C02F2103/04—Non-contaminated water, e.g. for industrial water supply for obtaining ultra-pure water
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2209/00—Controlling or monitoring parameters in water treatment
    • C02F2209/06—Controlling or monitoring parameters in water treatment pH
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F5/00—Softening water; Preventing scale; Adding scale preventatives or scale removers to water, e.g. adding sequestering agents

Definitions

  • the present invention relates to sterilized water for sterilizing periodontal pathogens that indwell deeply in periodontal pockets mainly as subgingival plaque, a method for generating the same, and a generation device.
  • dental plaque bacteria are roughly classified into epigingival plaque using saliva as a nutrient source and subgingival plaque using gingival crevicular fluid (blood component) as a nutrient source.
  • the strong subgingival plaque contains periodontal disease bacteria that cause periodontal disease.
  • periodontal disease is infected in about 80% of generations in their 30s.
  • periodontal disease is a life-threatening infectious disease. Establishing appropriate treatments for diseases has become an urgent task.
  • Ozone treatment is known as one of the treatment methods for periodontal disease. Ozone treatment itself has been widely used in the medical field because of its excellent sterilizing ability, but research has also started on its application to the oral cavity using the high sterilizing ability of ozone water.
  • Odori Ozone therapy has been reported to be a bactericidal agent against Streptococcus mutans, a type of streptococcal caries pathogen, but supragingival plaques are the mainstay. Aerobic Streptococcus mutans Even if it can be killed, the unstable ozone, which is easily broken down into water and oxygen, can kill the periodontosis that is anaerobic and inhabits deep in the periodontal pocket. It is unclear whether it can be done, rather there is a great concern that the ozone will decompose and become inactive before reaching the bottom of the periodontal pocket.
  • NaOCL sodium hypochlorite
  • CaOCL sodium hypochlorite
  • hypochlorous acid can hardly be present in aqueous solution at high pH, and instead changes its form to hypochlorite ion (CLO_), which has weak sterilizing power. with the first place because of the high risk of corroding the P H in irritation high human tissue it can not be used in the oral cavity. If the pH is lowered too much, extremely toxic chlorine gas is generated.
  • sodium hypochlorite NaOCL
  • NaOCL sodium hypochlorite
  • it is limited to disinfection, boil water disinfection, bleach, and disinfection of waste water after sewage treatment.
  • weakly acidic water in which sodium hypochlorite and hydrochloric acid are diluted and mixed and reacted to make the pH weakly acidic with a pH of 5.5 to 6.5 is commercially available, the use is generally within the above-described range, It is not intended for use in the dentistry field, but has been proven to be safe and effective as a treatment for periodontal disease!
  • Patent Document 1 Japanese Patent Laid-Open No. 9-183706
  • Patent Document 2 JP-A-10-87462
  • Patent Document 3 JP 2001-327975
  • Patent Document 4 JP-A-6-292892
  • Patent Document 5 JP-A-10-314746
  • Patent Document 6 Japanese Patent Laid-Open No. 63-286148
  • Patent Document 7 JP-A-5-76550
  • Patent Document 8 JP-A-4 994785
  • Patent Document 9 JP-A-7-313982
  • Patent Document 10 JP-A-8-19782
  • Patent Document 11 JP-A-8-108182
  • Patent Document 1 discloses hypochlorous acid sterilized water to be used in the oral cavity.
  • hydrochloric acid is added to a sodium chloride solution to perform electrolysis, and pH
  • Patent Document 2 discloses oral rinse water having a hypochlorous acid concentration of 5 to 55 ppm.
  • Patent Document 3 sodium chloride (NaCL), acetic acid and water are used as stock solutions, and hypochlorite ions (CLO_) are generated by electrolyzing the stock solution.
  • NaCL sodium chloride
  • acetic acid and water are used as stock solutions
  • hypochlorite ions (CLO_) are generated by electrolyzing the stock solution.
  • H hypo UnijiA chlorate
  • the use of chlorate ion (CLO_) has too much effect on human tissues.
  • Patent Document 4 discloses that sodium chloride (NaCL), an inorganic acid and water are used as a stock solution, and the stock solution is electrolyzed to produce active oxygen, and hypochlorous acid produced together with active oxygen. Although it has been described that it can be used in various fields such as food processing and distribution fields, including sterilized water for cooking and environmental hygiene, hand washing, food ingredients, and towels, etc. In the first place, no mention is made about the application to the dental field.
  • NaCL sodium chloride
  • an inorganic acid and water are used as a stock solution, and the stock solution is electrolyzed to produce active oxygen, and hypochlorous acid produced together with active oxygen.
  • Patent Document 5 discloses a new stock solution composition to solve the problems that have not been solved in Patent Documents 6 to 9, that is, the problems related to pH when used as oral cleansing water, It is disclosed that sterilized water consisting of about 30 ppm hypochlorous acid (HCLO) can be generated by electrolyzing a strong stock solution (Table 2, Fig. 3), and for preventing periodontal disease. Although it has been disclosed that it can be used (paragraph number 28), the bacterial cells actually tested do not contain periodontal disease bacteria, and their efficacy against periodontal disease bacteria is not clear. In the same way, it is impossible to kill periodontal disease bacteria with powerful sterilizing water.
  • HCLO hypochlorous acid
  • Patent Documents 10 and 11 are not premised on use in the oral cavity, and it is unclear whether or not there is an effect of killing dental plaque in the first place, as well as periodontal disease bacteria.
  • the periodontopathic bacteria threaten the danger of life. According to the known literature, how to kill the periodontopathic bacteria living deep in the periodontal pocket, and the means for that are all. It has not been revealed. As for sterilized water containing hypochlorous acid (HCLO), its main use is limited to sterilization of hands and production lines, and it is actually to kill periodontal bacteria that live in the periodontal pocket. It has been clarified by the applicant's clinical trial that this is impossible.
  • HCLO hypochlorous acid
  • hypochlorous acid In addition to various substances, especially substances that stimulate the taste and smell are generated. For this reason, there was a natural limit when used in the oral cavity.
  • the present invention has been made in consideration of the above-described circumstances, and can surely kill periodontal disease bacteria that have a pH satisfying both decalcification and bactericidal activity, and that indwell deeply in the periodontal pocket.
  • An object of the present invention is to provide a sterilizing water, a production method thereof, and a production apparatus.
  • the sterilizing water according to the present invention is sterilized water containing hypochlorous acid (HCLO), and the hypochlorous acid (HCLO)
  • HCLO hypochlorous acid
  • the concentration is 201 to 600 ppm
  • the pH is 5.6 to 7
  • the purpose is to kill periodontal disease bacteria that inhabit the periodontal pocket.
  • the sterilized water is from 201 to 600 ppm, and from 400 to 600 ppm.
  • the sterilizing water according to the present invention is 6.3 to 6.7 instead of 5.6 to 7.
  • the sterilizing water according to the present invention is 5.6 to 6.3 instead of 5.6 to 7.
  • the sterilizing water according to the present invention is a sterilizing water containing hypochlorous acid (HCLO), wherein the concentration of the hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7. Is.
  • HCLO hypochlorous acid
  • the stock solution is electrolyzed according to the electrolysis conditions, and then the primary product water generated by the electrolysis is diluted according to the dilution conditions.
  • the primary product water is Is injected into the dilution water through a predetermined discharge pipe.
  • the tip position of the discharge pipe is set to be equal to or lower than the water level of the dilution water.
  • hypochlorous acid HCLO
  • concentration of hypochlorous acid is set to 20 l to 600 ppm and the pH is set to 5.6 to 7, and the stock solution composition, electrolysis conditions and dilution conditions including the added amount of sodium chloride are set.
  • the tip position of the discharge pipe is intended to be equal to or less than the water level of the dilution water
  • the pH of the stock solution is calculated using the solubility of carbon dioxide and the concentration of carbon dioxide in the atmosphere at the temperature at which the stock solution is prepared,
  • the stock solution composition conditions, the electrolysis conditions, and the dilution conditions are set using the calculated values.
  • the method for producing sterilizing water according to the present invention is set to 400 to 6 OOppm instead of 201 to 600ppm. [0035] The method for producing sterilizing water according to the present invention is 6.3 to 6.7 instead of 5.6 to 7.
  • the method for producing sterilizing water according to the present invention is 5.6 to 6.3 instead of 5.6 to 7.
  • the sterilizing water generating apparatus is an apparatus for generating sterilizing water containing hypochlorous acid (HCLO) by electrolyzing a stock solution in an electrolytic cell as described in claim 13.
  • a stock solution tank for storing the stock solution, an electrolytic bath connected to the stock solution tank, a discharge pipe connected to the electrolytic bath, and a dilution water tank storing dilution water.
  • the dilution water tank is positioned relative to the tip of the discharge pipe so that the tip of the discharge pipe is below the level of the dilution water stored in the dilution water tank. It produces sterilized water for the purpose of sterilizing periodontal disease bacteria living in pockets.
  • the sterilizing water generating device is a sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria that inhabit the periodontal pocket.
  • a stock solution tank that stores a stock solution in which only sodium chloride is added to the passing water obtained by passing water through a reverse osmosis membrane, and an electrolysis of the stock solution connected to the stock solution tank.
  • An electrolytic cell that produces primary product water and dilution water that dilutes the primary product water that is discharged through a discharge pipe that is connected to the electrolytic tank to produce sterilization water is stored in advance.
  • the amount of sodium chloride added is 600 ppm and the pH is 5.6-7. Because, it is as defined prescribed or dilution conditions operating conditions of the electrolytic cell.
  • the sterilizing water generating device is a sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria that inhabit the periodontal pocket.
  • a stock solution tank for storing a stock solution in which pure water is added to salt water obtained by leaving pure water in the atmosphere for a predetermined period, and a stock solution tank connected to the stock solution tank to electrically connect the stock solution.
  • An electrolytic cell that decomposes to produce primary product water and dilution water that dilutes the primary product water discharged through a discharge pipe that is connected to the electrolytic cell to produce sterilization water are stored in advance.
  • a dilution water tank in which the discharge pipe is relatively positioned so that the tip of the discharge pipe is below the level of the dilution water, and the hypochlorous acid in the sterilizing water (
  • the amount of sodium chloride added is determined so that the concentration power of HCLO is 201 to 600 ppm and the pH is 5.6 to 7, the operating conditions of the electrolytic cell are determined, or the dilution conditions are determined.
  • the sterilizing water generator according to the present invention is not limited to the above-mentioned 201-600ppm, but 400-6
  • the sterilizing water generator according to the present invention is 6.3 to 6.7 instead of 5.6 to 7.
  • the sterilizing water generator according to the present invention is 5.6 to 6.3 instead of 5.6 to 7.
  • the pathogens of periodontitis are mainly anaerobic gram-negative bacilli and spirochetes.
  • the gram-negative bacilli Borphyromonas gingivalis (P. gingivalis), Actinobacillus actinomycetemcomitans (hereinafter "", A.actinomycetemc omitans), Prevotella intermedia, Bacteroides forsythus, Gram-negative short bacterium Eikenella corrodens, gram-negative bacteria, Campylobacter rectus, and Spirocheta, Treponema denticola (T.denticola).
  • the applicant of the present invention has conducted such a periodontopathic bacterium while performing laser treatment using an Er: YAG laser that generates a laser with a transpiration function of a wavelength of 2.94 ⁇ m and treatment with antibiotics. I learned how difficult it was to kill them, and researched the fact that it was impossible to use the sterilizing power of hypochlorous acid (HCLO), which has been known so far.
  • HCLO hypochlorous acid
  • periodontal disease bacteria live deep in the periodontal pocket as subgingival plaque, they contain known sterilized water containing hypochlorous acid (HCLO).
  • HCLO hypochlorous acid
  • the gingival plaque and the organic matter in the oral cavity are not only oxidized, but when injected directly into the periodontal pocket, the organic matter and the periodontal pocket accumulated in the periodontal pocket are removed.
  • Bactericidal power is consumed by acidifying other cells that inhabit. In any case, it was found that hypochlorous acid (HCLO) that preserved bactericidal power could not be fed deep into the periodontal pocket.
  • hypochlorous acid HCLO
  • the present applicant can prevent periodontopathic fungi even if the acidity gradually decreases before reaching the depth of the periodontal pocket.
  • the R & D perspective was shifted to increasing the concentration of hypochlorous acid (HCLO), thinking it could be killed.
  • HCLO hypochlorous acid
  • Digital Residual Chlorine Analyzer HI 95 Series is 0.00 to 5.
  • OOmg ZL “Pocket Residual Chlorine Meter (manufactured by NOCK)” is O. 02 to 2.
  • OOmg / L “Portable Residual Chlorine” “Total OR-52” is 0.05 to 2.
  • OOmg / L and “Portable water quality meter WA-1” is 0.05 to 2. OOmgZL.
  • products sold under the product name “Residual Chlorine Meter CR-200” by HORIBA Advanced Dotetano Co., Ltd. have a measuring range of 0 to 2. OmgZL, Emkeichi Ltd.
  • “Residual Chlorine Meter C- The products sold under the trade name “201 (completely waterproof)” are 0.01 to 6. OmgZL, and the upper limit of measurement is mostly 5 to 6 ppm.
  • Bayer Medical Co., Ltd. sells a test strip under the product name "Nissan Aqua Check HC" as a high-concentration test strip. , 100, 200, 400, 600 mgZL ”is explained to have a high range S (http: ⁇ www.aquachek.net/aq—08b06.html, December 14, 2005 Internet search ), “This method considers the measurement of high concentration sodium hypochlorite (strong alkalinity) (omitted) and uses a chromogen that has little effect on pH.” (Same as above) Regarding chlorine, it measures the concentration of sodium hypochlorite (strong alkaline), not hypochlorous acid (HCLO)! /.
  • HCLO hypochlorous acid
  • Tsumoto Rii Sangyo Sangyo Co., Ltd. is sold under the trade name “Simple Water Quality Test Kit Simple Pack” and says that “Residual chlorine 300 ClO300” can be measured in the concentration range of 50 to 300 mgZL.
  • the measurement object is hypochlorous acid (HCLO)
  • HCLO hypochlorite ion
  • hypochlorous acid HCLO
  • hypochlorous acid HCLO
  • acid water There is no acid water, and it is a known proof that it is not a known substance.
  • hypochlorous acid water for use in killing periodontal disease bacteria that reside in the periodontal pocket has been completely disclosed in the prior art, as described above. is there.
  • the sterilization time clarified by clinical trials is the time to kill all periodontal disease bacteria present on the entire circumference of one tooth, as described in Examples.
  • the sterilizing water according to the present invention has a hypochlorous acid (HCLO) concentration of 201 to 600 ppm and a pH of 5.
  • HCLO hypochlorous acid
  • the sterilizing water is injected into the periodontal pocket.
  • the sterilizing water gradually loses the sterilizing power due to oxidation of organic matter and other bacterial cells, but only sterilizes the periodontal disease bacteria when it reaches deep in the periodontal pocket. Because it retains acidity, periodontal disease bacteria can be killed reliably. Of course, tooth demineralization is also prevented at that time.
  • the reason why the concentration was set to 201 ppm or more is that it is difficult to achieve the above (a) to (c) at a concentration of 200 ppm or less. In order to achieve a) to (c), there is a force that is unnecessary concentration.
  • HCLO hypochlorous acid
  • hypochlorous acid When producing the sterilized water according to the present invention by adding hydrochloric acid or acetic acid, the stimulant substance generated at the same time as the production gives odor and taste to stimulate the patient, so hypochlorous acid (The concentration of HCLO) should be 500 ppm or less, and more preferably 400 ppm or less.
  • the Er: YAG laser By irradiating and scaling, the nanofilm existing deep in the periodontal pocket is removed in advance. Incidentally, it has become clear from the applicant's clinical trial that periodontal disease bacteria cannot be killed only by irradiation with an Er: YAG laser.
  • the sterilizing water according to the present invention is not limited to the use only for the sterilization of periodontal disease bacteria inhabiting the periodontal pocket, and can be applied to the sterilization of every part of the human body and every part of the human body. is there.
  • the application target is not limited to the human body.
  • chlorine is a chemical substance that changes its form, such as chlorine gas, hypochlorous acid (HCLO), and hypochlorite ion (CLO-), depending on the pH environment, and is toxic to chlorine gas. This is well known, and when dilution is performed to adjust the concentration, the pH changes and the form of chlorine changes.
  • hypochlorous acid HCLO
  • pH 2.2 to pH 7 a guide, hypochlorous acid in the percentage of effective chlorine present
  • Acid (HCLO) of about 80% or more
  • pH 2.8 to pH 6.7 hypochlorous acid (HCLO) of about 90% or more in the percentage of available chlorine
  • the pH of the sterilizing water is 5.6 to 7 (6.3 to 7), preferably 5.6 to 6. 7 or less (6.3 or more and 6. 7 or less) must be diluted so that it is very strictly within the range!
  • the sterilized water after dilution must of course have the desired high concentration.
  • HCLO concentration variation of hypochlorous acid
  • the inside of the electrolytic cell is adjusted to a strongly acidic side (for example, about pH 1), and the water pipe is joined to the discharge pipe connected to the electrolytic cell.
  • a strongly acidic side for example, about pH 1
  • the strongly acidic water that came out of the electrolytic cell was diluted about 10 3 to 10 5 times to obtain a large amount of hypochlorous acid water of several tens of ppm.
  • the method for producing sterilizing water in which the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7! / ⁇ is 6.3 to 7 is the conventional technique. Not revealed at all.
  • the present applicant has obtained the following new knowledge regarding a method for producing sterilizing water that can be produced safely and homogeneously while satisfying the strict and demands regarding concentration and pH.
  • the acid functions as a pH adjuster, any acid such as hydrochloric acid or acetic acid can be used.
  • the water that is a component of the stock solution can be well water, tap water, or the like, and it is not necessary to use pure water. However, it goes without saying that pure water that does not contain calcium ions, magnesium ions, etc. should be used to prevent electrode damage and electrode reaction deterioration in the electrolytic cell.
  • the dilution water is appropriately set so that the pH of the produced sterilization water is within the above-mentioned range.
  • the stock solution is put in an electrolytic cell according to electrolysis conditions, and the stock solution is electrolyzed.
  • the installation position of the dilution water tank is relatively positioned so that the tip position of the discharge pipe is equal to or lower than the level of the dilution water stored in the dilution water tank. Therefore, if the primary product water is injected into the dilution water through the discharge pipe, it is injected in a non-contact state with air.
  • the dilution water is measured in advance so that the primary product water is diluted at the dilution factor set in the dilution condition, and then stored in the dilution water tank, and the dilution water corresponds to the dilution factor. If an amount of primary product water has been injected into the dilution water tank, the injection operation is terminated.
  • hypochlorous acid water having a designed concentration and pH can be generated safely and homogeneously.
  • the dilution factor should be determined according to the required concentration of hypochlorous acid (HCLO)! For example, if hypochlorous acid water with a concentration of 400 ppm is required, the stock solution composition conditions and electrolysis conditions should be set appropriately so that the concentration of hypochlorous acid (HCLO) in the primary product water is 4000 ppm. At the same time, the dilution factor should be 10.
  • sterilized water having a concentration of hypochlorous acid (HCLO) of 201 to 600 ppm and a pH of 5.6 to 7 or 6.3 to 7 can be produced. According to such bactericidal water, it becomes possible to sterilize the periodontal disease bacteria that live in the periodontal pocket in a few seconds per tooth.
  • HCLO hypochlorous acid
  • the upper limit is 500 ppm, preferably 400 ppm.
  • the raw solution composition conditions, electrolysis conditions, and dilution conditions are set in substantially the same procedure as in the invention according to claim 6.
  • water is passed through a reverse osmosis membrane, and the stock solution is prepared by adding only sodium chloride to the passing water.
  • pure water is left in the atmosphere for a predetermined period.
  • the stock solution is prepared by adding only sodium chloride to the standing water, and no acid such as hydrochloric acid or acetic acid is added.
  • the main component composition condition is the amount of sodium chloride added.
  • the reverse osmosis membrane has a pore size of lmm / million, so it allows water molecules that are slightly smaller than it to pass, but larger molecules are not allowed to pass, and ions are not allowed to pass. Since it also has the function of electrical exclusion, even substances that are smaller than 1 millionth of an inch, such as sodium ions, are almost completely removed, just like other ions.
  • the pH of water that has passed through a reverse osmosis membrane or pure water that has been left in the atmosphere for a certain period of time depends on the diacid-carbon in the atmosphere, and it does not bother the addition of acids such as hydrochloric acid and acetic acid. In both cases, it is possible to obtain a weakly acidic stock solution in a state where the pH is almost determined and safely, and since the force and pH value are known, the electrolysis conditions and dilution conditions can be easily set. wear.
  • the dissolved substances contained in tap water and well water are removed in advance with a reverse osmosis membrane, or removed because they are pure water, and no hydrochloric acid or acetic acid is added. It is possible to produce tasteless and odorless sterilized water, and as a result, even if the concentration of hypochlorous acid (HCLO) is 500 ppm to 600 ppm, it will cause any discomfort to the patient and will be several seconds per tooth. It has an epoch-making effect that it can completely kill periodontal disease bacteria in a short time.
  • HCLO hypochlorous acid
  • the sterilized water produced by each of the production methods described above may not be used as the sterilized water according to the present invention
  • the water produced by injecting the primary produced water into the diluted water (hereinafter, secondary produced water)
  • secondary produced water By removing dissolved gas from the water and using this as sterilizing water, it is possible to prevent foaming in the periodontal pocket and more reliably prevent the periodontal bacteria from being sent into the body (intravascular).
  • the tertiary product water tank that stores the tertiary product water as sterilizing water is connected to the dilution water tank, and between the tertiary product water tank and the dilution water tank. If there is a means for removing dissolved gas, it will be necessary.
  • a hollow fiber membrane deaeration module sold by Dainippon Ink & Chemicals, Inc. can be used. If a powerful hollow fiber membrane deaeration module is used, Dissolved oxygen can be degassed to the lppb level, and foaming in the periodontal pocket can be reliably prevented.
  • FIG. 1 is a schematic diagram showing a sterilizing water generator according to a first embodiment.
  • FIG. 2 is a schematic view showing a sterilizing water generator according to a modification.
  • FIG. 3 is a graph showing the effect of sterilizing water according to the present embodiment.
  • FIG. 4 is a graph showing the effect of sterilizing water according to the present embodiment.
  • FIG. 5 is a diagram showing the difference in action and effect between sterilization methods (before sterilization).
  • FIG. 6 A diagram showing the difference in action and effect of the sterilization method (after scaling).
  • FIG. 7 is a diagram showing the difference in action and effect of the sterilization method (after laser treatment).
  • FIG. 8 is a diagram showing the difference in action and effect by the sterilization method (high concentration hypochlorous acid water).
  • FIG. 9 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to the present embodiment is used for a patient with severe periodontal disease.
  • FIG. 10 A diagram showing the state after treatment.
  • FIG. 11 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to the present embodiment is used for a patient with severe periodontal disease.
  • FIG. 13 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 15 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 17 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 19 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 21 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 23 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 25 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 27 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 29 Using sterilized water (high concentration hypochlorous acid water) according to this embodiment for patients with severe periodontal disease The figure which showed the mode before treatment in the case of a case.
  • FIG. 31 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to the present embodiment is used for a patient with severe periodontal disease.
  • FIG. 33 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 35 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 37 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.
  • FIG. 39 is a schematic view showing a sterilizing water generator according to a second embodiment.
  • ⁇ 40 Schematic showing a sterilizing water generator according to a modification.
  • FIG. 41 is a view showing a state after treatment when sterilized water having a concentration of hypochlorous acid (HCLO) of 200 ppm and a pH of 6.3 to 6.7 is used.
  • HCLO hypochlorous acid
  • ⁇ 45 A diagram showing the state after treatment when similar sterilized water is used.
  • FIG. 48 is a diagram showing a state after treatment when sterilized water having a concentration of hypochlorous acid (HCLO) of 500 ppm and a pH of 6.3 to 6.7 is used.
  • HCLO hypochlorous acid
  • the sterilized water according to the present embodiment has a concentration of hypochlorous acid (HCLO) of 300 to 400 ppm, a pH of 6.3 to 6.7, and a periodontal disease bacterium that inhabits the periodontal pocket. It is intended for sterilization.
  • HCLO hypochlorous acid
  • 300 ppm or more is not only to retain the oxidizing power to kill periodontal bacteria when reaching deep in the periodontal pocket, but also to completely kill periodontal bacteria within a few seconds
  • the reason for setting it to 400 ppm or less is to alleviate irritation to the oral cavity.
  • the biofilm existing deep in the periodontal pocket is obtained by performing irradiation and scaling of an Er: YAG laser. Remove in advance.
  • an irrigation chip cleaning chip
  • the tip of the irrigation chip is inserted into the periodontal pocket to inject the sterilizing water according to the present embodiment.
  • Bacterial water can be injected.
  • the concentration of hypochlorous acid (HCLO) is adjusted to 300 to 400 ppm, so that the periodontal disease bacteria that live deep in the periodontal pocket can be detected within a few seconds (400 ppm). It can be completely sterilized instantaneously at nearby concentrations.
  • T. denticola has an action to suppress immune responses It has been elucidated that no antibodies are produced.
  • T. denticola has an immunosuppressive factor, and this immunosuppressive factor inhibits the antigen recognition function of macrophages. Therefore, even if T. denticola is present, antibodies against T. denticola are not generated.
  • T. denticola's immunosuppressive factor effective in suppressing the immune response against other periodontal pathogens, and as a result, T. denticola, along with other periodontal pathogens, is contained in the periodontal pocket. Increase rapidly.
  • the sterilizing water according to this embodiment that can instantly sterilize the periodontal disease bacteria in the periodontal pocket is truly epoch-making, and its action and effect are remarkable as described in the examples described later. In a word.
  • periodontal disease bacteria that were said to be difficult to kill can be completely sterilized, not only the supragingival plaque but also other subgingival plaques that inhabit the periodontal pocket. Naturally, it can be completely sterilized.
  • Streptococcus sanguis which is the most common dental plaque on the gingival margin and causes subacute bacterial endocarditis, and the bacterial heart Streptococcus mitis, the causative agent of membrane inflammation, can also be killed.
  • FIG. 1 shows a production apparatus for producing sterilizing water according to this embodiment.
  • the sterilizing water generator 1 includes a stock solution tank 3 that stores a stock solution 2, a stroke pump 4 that is connected to the stock solution tank, and the stroke pump.
  • An electrolyzer 5 connected to the electrolyzer, a discharge pipe 6 connected to the electrolyzer, a diluting water tank 8 storing diluting water 7, and a water level measuring means for measuring the water level in the diluting water tank
  • the dilution water tank 8 is installed at the tip of the discharge pipe 6 so that the tip of the discharge pipe 6 is equal to or lower than the water level of the dilution water 7 stored in the dilution water tank 8. The position is relatively positioned.
  • Stock solution 2 can be composed of, for example, sodium chloride sodium (NaCL), hydrochloric acid (HCL), and water, but hydrochloric acid functions as a pH adjuster, so any acid such as acetic acid can be used. wear.
  • NaCL sodium chloride sodium
  • HCL hydrochloric acid
  • water water
  • hydrochloric acid functions as a pH adjuster, so any acid such as acetic acid can be used. wear.
  • electrolytic cell 5 for example, an electrolytic cell used in an electrolytic neutral water generator sold by Sakai Engineering Co., Ltd. under the trade name "Epiosuko" can be used.
  • the water level sensor 9 may be appropriately selected, for example, an ultrasonic sensor or an electrode type sensor.
  • dilution water 7 well water, tap water, pure water or any other water can be used.
  • the pH is appropriately selected so that the pH of the sterilized water to be generated is in the above-mentioned range.
  • the production apparatus 1 further includes a deaeration module 11 in which the water injection side is communicated with the secondary production water 10 in which the primary production water is diluted with the dilution water 7 in the dilution water tank 8.
  • the deaeration module is adapted to remove dissolved oxygen in the secondary product water 10 by decompression by the vacuum pump 12, and the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 10. Is provided with a tertiary production water tank 14 for storing as a sterilizing water 13.
  • the degassing module 11 for example, a hollow fiber membrane degassing module sold by Dainippon Ink & Chemicals, Inc. can be used.
  • a degassing module for chemicals that uses polytetrafluoroethylene hollow fiber as the degassing membrane and all wetted parts are fluorocoating is desirable.
  • the tubes used in the generating device 1 or the electromagnetic valve provided as necessary are likely to be deteriorated by acid with high-concentration hypochlorous acid (HCLO) and are therefore formed with fluorine. Is desirable.
  • the concentration of hypochlorous acid (HCLO) in the secondary produced water is 300 to 400 ppm, pH
  • the blended stock solution 2 is stored in the stock solution tank 3.
  • the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 7 stored in the dilution water tank 8. is there.
  • the amount of the dilution water 7 is measured in advance so that the primary product water is diluted at the dilution rate, and the measured water level increase value obtained by the water level sensor 9 is a target corresponding to the dilution rate.
  • the water level rise value is reached, the primary water injection through the discharge pipe 6 is terminated.
  • the secondary product water 10 is passed through the deaeration module 11 to generate tertiary product water from which dissolved gas, particularly dissolved oxygen, has been removed. Store in tank 14.
  • the dissolved gas is removed from the secondary product water 10 to produce the tertiary product water 13, which is Since it is sterilized water, it prevents foaming in the periodontal pocket and sends periodontal disease bacteria into the body (intravascular). Therefore, it becomes possible to prevent the situation from occurring.
  • the dissolved gas in the secondary product water 10 is removed using the degassing module 11.
  • the concentration of the dissolved gas in the secondary product water 10 is low, so that the foaming phenomenon occurs. If there is no concern that this will occur, the process of removing dissolved gas can be omitted. In such a case, the secondary product water 10 is sterilized water.
  • FIG. 2 is a diagram showing the generator la used when the dissolved gas removal step is omitted.
  • the degassing module 11, the vacuum pump 12, and the tertiary product water tank 14 are omitted from the generator 1.
  • the force using the water level sensor 9 as the water level measuring means is used as the water level measuring means.
  • a scale is attached to the dilution water tank 8 in advance, and the water level is measured using this scale as a guide. It does n’t work.
  • the water level measurement means may be omitted and the measurement may be performed separately.
  • the sterilizing water, its generating method and generating device for the purpose of sterilizing periodontal disease bacteria that inhabits in the periodontal pocket have been described.
  • (HCLO) concentration is 201-500ppm and pH is 6.3-7, so it is inherently strong bactericidal and has a pH near neutral. Is unthinkable.
  • the sterilizing water according to the present invention is not limited to the use only for the sterilization of periodontal disease bacteria living in the periodontal pocket, but can be applied to the sterilization of any part of the human body and any part. It is.
  • the application target is not limited to the human body.
  • the sterilizing water generating method and generating device can directly apply the generating method and generating device of the present embodiment.
  • Example 1
  • the test was performed using an Er: YAG laser (repetition rate 30pps, laser beam output energy 60m jZ pulse) to remove the biofilm of all teeth while injecting 20ppm low concentration hypochlorous acid water.
  • an irrigation chip was attached to the ultrasonic scaler, and high-concentration hypochlorous acid water was injected.
  • the high-concentration hypochlorous acid water had a pH of 6.5 and a concentration of 200, 300, 400 ppm.
  • 20 ppm of low-concentration hypochlorous acid water was used, treatment was performed before treatment, and when high-concentration hypochlorous acid water was used, after treatment.
  • the state of periodontal disease bacteria before and after treatment was determined by inserting a probe into the bottom of the periodontal pocket without touching saliva, collecting plaque and blood adhering to the root surface, and sliding it. After placing on glass and suspending in physiological saline, it was covered with a cover glass and observed with a high-resolution phase-contrast microscope at 3600 times.
  • Fig. 3 is a graph showing the tendency of sterilization in 10 seconds, 20 seconds, and 30 seconds, respectively.
  • the level at which the tendency is seen, and the bactericidal level 2 indicate the level at which complete sterilization has been achieved.
  • the time for injecting high-concentration hypochlorous acid water into the periodontal pocket means the time for injecting per tooth, in other words, over the entire circumference of one tooth.
  • Fig. 4 is a graph showing the relationship between the concentration of hypochlorous acid (HCLO) and the complete sterilization time.
  • the concentration force S200ppm is about 40%, 300ppm
  • the complete sterilization time is the period within a periodontal pocket distributed per tooth, in other words, around the entire circumference of one tooth. It shall mean the time required to inject hypochlorous acid water to disinfect all periodontal disease bacteria.
  • the bactericidal effect due to the difference in treatment method was verified.
  • Figure 5 shows sterilization, Figure 6 after scaling, Figure 7 after laser treatment (30pps, 60mjZ pulse), and Figure 8 after treatment with high-concentration hypochlorous acid (400ppm).
  • a still image is cut out from a moving image photographed through a high-resolution phase-contrast microscope (3600 times). Scaling and laser treatment were performed while injecting 20ppm low concentration hypochlorous acid water. Further, high-concentration hypochlorous acid water was poured into an ultrasonic scaler with an irrigation chip as in Example 2.
  • periodontal disease bacteria such as spirochetes were removed by scaling ( Figure 6) and laser treatment ( Figure 7) using 20ppm low-concentration hypochlorous acid water. It is almost the same as before the bacterium (Fig. 5), but it is almost dead (the spirochete that is a spiral bacterium is active in moving images). On the other hand, when treated with 400ppm high concentration hypochlorous acid water (Fig. 8), most of the bacteria, including periodontal disease bacteria, have been killed.
  • Fig. 9 shows the state before treatment
  • Fig. 10 shows that the biofilm was removed by laser treatment, and as in Examples 2 and 3, an irrigation tip was attached to the ultrasonic scaler and high concentration hypochlorous acid was added. It shows the state after injecting water into the periodontal pocket for 10 seconds (after treatment), and the V-shift is also a still image from a moving image taken through a high-resolution phase-contrast microscope (3600 times). An image is cut out.
  • FIGS. 11 to 38 similarly show the pre-treatment and post-treatment states for another severe patient.
  • the sterilized water according to the present embodiment has a concentration of hypochlorous acid (HCLO) of 300 to 600 ppm, a pH of 6.3 to 6.7, and a periodontopathic bacterium that resides in the periodontal pocket. It is intended for sterilization.
  • HCLO hypochlorous acid
  • the level of 300 ppm or more not only retains the oxidizing power to kill periodontal bacteria when reaching deep into the periodontal pocket, but also completely kills periodontal bacteria within a few seconds.
  • the reason why it is set to 600 ppm or less is that it is not necessary to increase the concentration to sterilize the periodontal bacteria in the periodontal pocket!
  • the sterilizing water according to this embodiment since the concentration of hypochlorous acid (HCLO) is adjusted to 300 to 600 ppm, periodontal disease bacteria that inhabit deep in the periodontal pocket can be detected for several seconds. It can be completely sterilized within a moment (at a concentration of around 400-600ppm), and it is said that it cannot be killed.
  • the sterilizing water according to the present embodiment capable of instant sterilization is epoch-making as in the first embodiment.
  • FIG. 39 shows a generating apparatus for generating sterilizing water according to this embodiment.
  • the sterilizing water generator 21 includes a stock solution tank 3 that stores a stock solution 22, a stroke pump 4 that is connected in communication with the stock solution tank, and the stroke pump.
  • the electrolytic tank 5 is connected in communication
  • the discharge pipe 6 is connected in communication with the electrolytic tank
  • the dilution water tank 8 is stored with the dilution water 27, and the tip of the discharge pipe 6 is stored in the dilution water tank 8.
  • the installation position of the dilution water tank 8 is relatively positioned with respect to the tip position of the discharge pipe 6 so as to be equal to or lower than the water level of the diluted water 27 that has been prepared.
  • Stock solution 22 is made by adding only sodium chloride (NaCL) to the water obtained by passing tap water through the reverse osmosis membrane, and adding acids such as hydrochloric acid and acetic acid! ⁇ ⁇ .
  • NaCL sodium chloride
  • electrolytic cell 5 for example, an electrolytic cell used in an electrolysis neutral water generator sold by Sakai Engineering Co., Ltd. under the trade name "Epiosuko" can be used.
  • dilution water 27 well water, tap water, pure water or any other water can be used, and the pH is appropriately selected so that the pH of the sterilized water to be generated is in the above-mentioned range.
  • the generation device 21 further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 30 in which the primary generation water is diluted with the dilution water 27 in the dilution water tank 8.
  • the deaeration module is adapted to remove dissolved oxygen from the secondary product water 30 by depressurization by the vacuum pump 12, and to remove the dissolved oxygen from the secondary product water 30.
  • a tertiary production water tank 14 for storing water as sterilizing water 33 is provided.
  • tubes used in the generating device 21 or the electromagnetic valve provided as needed are likely to be deteriorated by the acid concentration of high-concentration hypochlorous acid (HCLO), and are therefore formed of fluorine. Is desirable.
  • the water may have any properties, but in order to reduce the burden on the reverse osmosis membrane and the water purifier using it, or to reduce the amount of waste water to some extent, Drowned water is desirable, and it is desirable to use water with a pH close to neutral in the sense that it produces sterilized water more safely.
  • Drowned water is desirable, and it is desirable to use water with a pH close to neutral in the sense that it produces sterilized water more safely.
  • ground water, tap water, or commercially available mineral water (commercial water) can be used.
  • the amount of sodium chloride sodium added and the electrolysis conditions are determined by the concentration of hypochlorous acid (HCLO) after the primary water produced by electrolysis is diluted. Is set appropriately so that secondary product water of 300 to 600 ppm and pH of 6.3 to 6.7 is generated.
  • HCLO hypochlorous acid
  • the dilution water tank 8 is filled with an amount of dilution water 27 corresponding to the dilution ratio.
  • the primary generated water generated in the electrolytic cell 5 is injected into the diluted water 27 stored in advance in the diluted water tank 8 through the discharge pipe 6 connected to the electrolytic cell. To do.
  • the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or less than the level of the dilution water 27 stored in the dilution water tank 8. is there.
  • the secondary product water 30 is passed through the deaeration module 11 to produce tertiary product water from which dissolved gases, particularly dissolved oxygen, have been removed. Store in tank 14.
  • the pH of the water that has passed through the reverse osmosis membrane depends on carbon dioxide in the atmosphere, and is approximately 5%. ⁇ 6.
  • the dissolved gas is removed from the secondary generated water 30 to generate the tertiary generated water 33, which is used as the sterilizing water. Therefore, it is possible to prevent the foaming phenomenon in the periodontal pocket and prevent the periodontal disease bacteria from being sent into the body (intravascular).
  • water is passed through a reverse osmosis membrane, and only saline and sodium chloride are added to the passing water to prepare a stock solution.
  • pure water is used in the atmosphere for a predetermined period of time.
  • the stock solution may be prepared by adding only sodium chloride to the standing water.
  • the degassing module 11 is used to remove dissolved gas in the secondary product water 30.
  • the concentration of the dissolved gas in the secondary product water 30 is low and there is no concern about the foaming phenomenon, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 30 is sterilized water.
  • FIG. 40 is a diagram showing the generation device 21a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generation device 21. .
  • the sterilizing water, its generating method and generating device for the purpose of sterilizing periodontal disease bacteria that live in the periodontal pockets have been described, but the sterilizing water according to the present invention is hypochlorous acid. (HCLO) concentration is 201-600ppm and pH is 6.3-7, so it is inherently strong bactericidal and pH is near neutral. Is unthinkable.
  • HCLO hypochlorous acid
  • the sterilizing water according to the present invention is not limited to use only for sterilization of periodontal disease bacteria living in the periodontal pocket, but can be applied to sterilization of any part of the human body and any part. It is.
  • the application target is not limited to the human body.
  • the generation method and the generation apparatus of the present embodiment can be applied as they are to the generation method and generation apparatus of the sterilizing water.
  • tap water was poured into a water purifier equipped with a reverse osmosis membrane, and then sodium chloride (NaCL) was added to the water that passed through the reverse osmosis membrane to prepare a stock solution.
  • NaCL sodium chloride
  • the stock solution was electrolyzed in an electrolytic cell to produce primary product water, and the primary product water was diluted with tap water.
  • the electrolytic cell used was an electrolytic neutral water generation device sold by Sakai Engineering Co., Ltd. under the trade name "Epiosuko".
  • the discharge pipe connected to the electrolytic cell is relatively positioned between the discharge pipe and the dilution water tank so that the tip of the discharge pipe is below the level of the dilution water stored in the dilution water tank. Positioned.
  • Figures 41 to 47 show the results. As can be seen from these figures, scaling with 200 ppm hypochlorous acid water can confirm the bactericidal effect to some extent, but Campylobacter rectus and Treponema a denticola (Treponem a denticola ) Is still active, and it can be seen that complete sterilization has not been achieved. In addition, the results of this example also supported the test results of Example 1.

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Abstract

Selon l’invention, les bactéries parodontales vivant au fond d’une poche parodontale sont totalement détruites à un pH permettant une décalcification et une stérilisation. Une eau bactéricide, destinée à être utilisée pour détruire totalement des bactéries parodontales d’une poche parodontale, contient de l’acide hypochloreux (HCLO) en une concentration de 201 à 600 ppm et possède un pH allant de 5,6 à 7. La raison d’un tel pH pour une concentration de 201 ppm ou plus est qu’il faut d’une part, maintenir une intensité oxydative permettant la destruction des bactéries parodontales au moment où le fond de la poche parodontale est atteint, et d’autre part, parvenir à une destruction en l’espace de quelques secondes.
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WO2009098873A1 (fr) * 2008-02-08 2009-08-13 Noguchi Dental Medical Research Institute Eau stérilisée, et procédé et dispositif de production de l'eau
WO2009098870A1 (fr) 2008-02-08 2009-08-13 Noguchi Dental Medical Research Institute Eau de stérilisation dentaire, procédé de production de l'eau, et dispositif de production de l'eau
WO2010004699A1 (fr) * 2008-07-09 2010-01-14 野口歯科医学研究所株式会社 Agent d'élimination la mauvaise haleine et son procédé de production
JP2010126506A (ja) * 2008-11-28 2010-06-10 Tokyo Medical & Dental Univ 口腔洗浄用キット
WO2011058764A1 (fr) * 2009-11-16 2011-05-19 パーフェクトペリオ株式会社 Préparation pour gargarisme, procédé et appareil pour sa production
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KR20160067835A (ko) 2013-08-07 2016-06-14 하이크로테크 메디칼 재팬 씨오., 엘티디 액체 구강 세정제
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WO2020054494A1 (fr) * 2018-09-13 2020-03-19 株式会社トクヤマデンタル Composition de nettoyage dentaire, agent de nettoyage dentaire, accélérateur d'élimination de tartre dentaire et procédé de nettoyage dentaire
RU2779051C1 (ru) * 2018-09-13 2022-08-31 Токуяма Дентал Корпорейшн Состав для чистки зубов, средство для чистки зубов, ускоритель для удаления минерализованных отложений на поверхности зубов и способ чистки зубов
US11452778B2 (en) 2011-03-18 2022-09-27 Urgo Us, Inc. Stabilized hypohalous acid solutions
EP3730123A4 (fr) * 2017-12-21 2022-10-26 OPT Creation Inc. Procédé de soins buccaux et système de soins buccaux
KR20230090641A (ko) * 2021-12-15 2023-06-22 강원대학교산학협력단 미산성 차아염소산수, 식물성 정유, 모노라우린을 포함하는 나노에멀젼 형태의 구강청결제 조성물

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