WO2007072697A1

WO2007072697A1 - Bactericidal water, method of producing the same and apparatus for producing the same

Info

Publication number: WO2007072697A1
Application number: PCT/JP2006/324568
Authority: WO
Inventors: Munenori Noguchi
Original assignee: Noguchi Dental Medical Research Institute
Priority date: 2005-12-20
Filing date: 2006-12-08
Publication date: 2007-06-28
Also published as: JPWO2007072697A1

Abstract

Periodontal bacteria living in the deep part of a periodontal pocket are exterminated at such a pH value as enabling both of decalcification and sterilization. A bactericidal water, which is to be used in exterminating periodontal bacteria living in a periodontal pocket, containing hypochlorous acid(HCLO) at a concentration of from 201 to 600 ppm and having a pH value of from 5.6 to 7. The reason for adjusting the pH value thereof to 201 ppm or above is that an oxidization intensity for exterminating the periodontal bacteria should be sustained at the point of reaching the deep part of the periodontal pocket and, furthermore, the periodontal bacteria should be exterminated within several seconds.

Description

Specification

Bactericidal water, method for producing the same, and production device

Technical field

The present invention relates to sterilized water for sterilizing periodontal pathogens that indwell deeply in periodontal pockets mainly as subgingival plaque, a method for generating the same, and a generation device.

Background art

[0002] Among the bacteria detected in the oral cavity, dental plaque bacteria are roughly classified into epigingival plaque using saliva as a nutrient source and subgingival plaque using gingival crevicular fluid (blood component) as a nutrient source. The strong subgingival plaque contains periodontal disease bacteria that cause periodontal disease.

[0003] In gingivitis and periodontal disease, first, plaque adheres to the gingival crevice between the tooth and gingiva, and this plaque causes gingivitis. A deep sulcus called a periodontal pocket is formed between them, and periodontal disease develops.

[0004] As the condition progresses from gingivitis to periodontal disease, the teeth become wobbled and eventually the teeth are lost, but since periodontal disease bacteria are carried throughout the body through the blood, Not only does it cause various diseases such as hematosis, myocardial infarction, angina pectoris, bacterial endocarditis, arteriosclerosis, hypertension, pneumonia, and sepsis, but it also exacerbates the pathology of diabetes, or It has recently been elucidated that it can cause premature birth and premature infants (underweight infants).

[0005] On the other hand, it is said that periodontal disease is infected in about 80% of generations in their 30s. As mentioned above, periodontal disease is a life-threatening infectious disease. Establishing appropriate treatments for diseases has become an urgent task.

[0006] Ozone treatment is known as one of the treatment methods for periodontal disease. Ozone treatment itself has been widely used in the medical field because of its excellent sterilizing ability, but research has also started on its application to the oral cavity using the high sterilizing ability of ozone water.

[0007] Odori Ozone therapy has been reported to be a bactericidal agent against Streptococcus mutans, a type of streptococcal caries pathogen, but supragingival plaques are the mainstay. Aerobic Streptococcus mutans Even if it can be killed, the unstable ozone, which is easily broken down into water and oxygen, can kill the periodontosis that is anaerobic and inhabits deep in the periodontal pocket. It is unclear whether it can be done, rather there is a great concern that the ozone will decompose and become inactive before reaching the bottom of the periodontal pocket.

[0008] Power! In order to expect a sufficient bactericidal effect with ozone therapy, ozone concentrations of at least 4 ppm are required. At such concentrations, the ozone gas power volatilized by the ozone water force, irritation of the upper respiratory tract, headache, etc. , Chest pain, coughing (coughing, coughing), there is a concern that it may cause an increase in pulse rate and anesthesia symptoms as well as causing symptoms, and it is a therapy that still has problems in terms of safety .

[0009] As a second treatment method, there is a widespread treatment method that kills periodontal disease bacteria by administration of antibiotics. It ’s not perfect for treating peri-disease.

[0010] Plaque that adheres to the surface of the teeth is not inside as a floating bacterium, but is blocked by the biofilm made of the exopolysaccharide that is produced by itself, blocking the host defense mechanism and antibiotics that are external enemies. Continue to grow slowly while maintaining a protected state. This is a so-called biofilm infection, which makes it difficult to treat with antibiotics.

[0011] In addition, the conventional ability of bactericidal properties of sodium hypochlorite (NaOCL, sodium hypochlorite) is widely known, but what actually has bactericidal power is that produced by hydrolysis. Although it is chlorous acid (HCLO), such hypochlorous acid can hardly be present in aqueous solution at high pH, and instead changes its form to hypochlorite ion (CLO_), which has weak sterilizing power. with the first place because of the high risk of corroding the _P H in irritation high human tissue it can not be used in the oral cavity. If the pH is lowered too much, extremely toxic chlorine gas is generated.

[0012] For this reason, sodium hypochlorite (NaOCL) is prepared by adding acid beforehand to lower the pH, disinfecting hands, disinfecting fruits and vegetables, disinfecting food production lines, bathrooms, etc. At present, it is limited to disinfection, boil water disinfection, bleach, and disinfection of waste water after sewage treatment. [0013] Further, although weakly acidic water in which sodium hypochlorite and hydrochloric acid are diluted and mixed and reacted to make the pH weakly acidic with a pH of 5.5 to 6.5 is commercially available, the use is generally within the above-described range, It is not intended for use in the dentistry field, but has been proven to be safe and effective as a treatment for periodontal disease!

Patent Document 1: Japanese Patent Laid-Open No. 9-183706

Patent Document 2: JP-A-10-87462

Patent Document 3: JP 2001-327975

Patent Document 4: JP-A-6-292892

Patent Document 5: JP-A-10-314746

Patent Document 6: Japanese Patent Laid-Open No. 63-286148

Patent Document 7: JP-A-5-76550

Patent Document 8: JP-A-4 994785

Patent Document 9: JP-A-7-313982

Patent Document 10: JP-A-8-19782

Patent Document 11: JP-A-8-108182

Disclosure of the invention

Problems to be solved by the invention

[0015] Here, Patent Document 1 discloses hypochlorous acid sterilized water to be used in the oral cavity. As an example, hydrochloric acid is added to a sodium chloride solution to perform electrolysis, and pH However, it is stated that sterilized water with a residual chlorine concentration of 50 ppm can be produced. Patent Document 2 discloses oral rinse water having a hypochlorous acid concentration of 5 to 55 ppm.

However, in the clinical trial of the present applicant, it is impossible to kill periodontal pathogens that are anaerobic pathogens and inhabit deep in the periodontal pockets with powerful sterilizing water and washing water. It was revealed. In the claims in Patent Document 1, the force in which the pH range is 3 to 8 At least in the range of about pH 3 to pH 5, it should not be used in the oral cavity where the risk of decalcification is strong. Can not.

[0017] In Patent Document 3, sodium chloride (NaCL), acetic acid and water are used as stock solutions, and hypochlorite ions (CLO_) are generated by electrolyzing the stock solution. Used terms as is disclosed that by which force hypochlorite ions (CLO_) road water, not only from the sterilizing power is small by the above-described UnijiA chlorate (HClO), high, may exist in _P H hypo The use of chlorate ion (CLO_) has too much effect on human tissues.

[0018] Further, Patent Document 4 discloses that sodium chloride (NaCL), an inorganic acid and water are used as a stock solution, and the stock solution is electrolyzed to produce active oxygen, and hypochlorous acid produced together with active oxygen. Although it has been described that it can be used in various fields such as food processing and distribution fields, including sterilized water for cooking and environmental hygiene, hand washing, food ingredients, and towels, etc. In the first place, no mention is made about the application to the dental field.

[0019] In addition, Patent Document 5 discloses a new stock solution composition to solve the problems that have not been solved in Patent Documents 6 to 9, that is, the problems related to pH when used as oral cleansing water, It is disclosed that sterilized water consisting of about 30 ppm hypochlorous acid (HCLO) can be generated by electrolyzing a strong stock solution (Table 2, Fig. 3), and for preventing periodontal disease. Although it has been disclosed that it can be used (paragraph number 28), the bacterial cells actually tested do not contain periodontal disease bacteria, and their efficacy against periodontal disease bacteria is not clear. In the same way, it is impossible to kill periodontal disease bacteria with powerful sterilizing water.

[0020] In addition, Patent Documents 10 and 11 are not premised on use in the oral cavity, and it is unclear whether or not there is an effect of killing dental plaque in the first place, as well as periodontal disease bacteria.

[0021] As described above, the periodontopathic bacteria threaten the danger of life. According to the known literature, how to kill the periodontopathic bacteria living deep in the periodontal pocket, and the means for that are all. It has not been revealed. As for sterilized water containing hypochlorous acid (HCLO), its main use is limited to sterilization of hands and production lines, and it is actually to kill periodontal bacteria that live in the periodontal pocket. It has been clarified by the applicant's clinical trial that this is impossible.

[0022] Further, in the conventional method for producing sterilizing water, hydrochloric acid and acetic acid have to be added, pH control becomes difficult, and the initial power is combined with components contained in water, so that hypochlorous acid (HCLO) In addition to various substances, especially substances that stimulate the taste and smell are generated. For this reason, there was a natural limit when used in the oral cavity.

Means for solving the problem

[0023] The present invention has been made in consideration of the above-described circumstances, and can surely kill periodontal disease bacteria that have a pH satisfying both decalcification and bactericidal activity, and that indwell deeply in the periodontal pocket. An object of the present invention is to provide a sterilizing water, a production method thereof, and a production apparatus.

[0024] It is another object of the present invention to provide a method and an apparatus for generating sterilizing water that are easy to control pH and do not generate a substance that stimulates taste and smell.

[0025] In order to achieve the above object, as described in claim 1, the sterilizing water according to the present invention is sterilized water containing hypochlorous acid (HCLO), and the hypochlorous acid (HCLO) The concentration is 201 to 600 ppm, the pH is 5.6 to 7, and the purpose is to kill periodontal disease bacteria that inhabit the periodontal pocket.

[0026] Further, according to the present invention, the sterilized water is from 201 to 600 ppm, and from 400 to 600 ppm.

[0027] The sterilizing water according to the present invention is 6.3 to 6.7 instead of 5.6 to 7.

[0028] The sterilizing water according to the present invention is 5.6 to 6.3 instead of 5.6 to 7.

[0029] The sterilizing water according to the present invention is a sterilizing water containing hypochlorous acid (HCLO), wherein the concentration of the hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7. Is.

[0030] Further, according to the method for producing sterilizing water according to the present invention, as described in claim 6, primary produced water obtained by electrolyzing a stock solution obtained by adding sodium chloride and an acid to water is diluted. Thus, a method for producing bactericidal water for producing bactericidal water for the purpose of bactericidal treatment of periodontal disease bacteria living in the periodontal pocket, wherein the concentration of hypochlorous acid contained in the bactericidal water is 201 to The stock solution composition conditions, electrolysis conditions and dilution conditions including the added amount of sodium chloride and acid are set so that the pH is 5.6-7, and the stock solution is prepared according to the stock solution composition conditions. Then, the stock solution is electrolyzed according to the electrolysis conditions, and then the primary product water generated by the electrolysis is diluted according to the dilution conditions. In the dilution step, the primary product water is Is injected into the dilution water through a predetermined discharge pipe. In addition, at the time of injection, the tip position of the discharge pipe is set to be equal to or lower than the water level of the dilution water. [0031] Further, according to the method for producing sterilizing water according to the present invention, as described in claim 7, water is passed through a reverse osmosis membrane, and only sodium chloride sodium is added to the passing water to obtain a stock solution. Is a method for producing sterilized water by diluting the primary produced water to produce sterilized water containing hypochlorous acid (HCLO), which is contained in the sterilized water. The concentration of hypochlorous acid is set to 20 l to 600 ppm and the pH is set to 5.6 to 7, and the stock solution composition, electrolysis conditions and dilution conditions including the added amount of sodium chloride are set. After preparing a stock solution according to the stock solution composition conditions, electrolyzing the stock solution according to the electrolysis conditions, and then diluting the primary product water generated by the electrolysis according to the dilution conditions, Injecting the primary product water into the dilution water through the specified discharge pipe When the injection, the tip position of the discharge pipe is intended to be equal to or less than the water level of the dilution water

[0032] Further, in the method for producing sterilizing water according to the present invention, as described in claim 8, pure water is left in the atmosphere for a predetermined period, and only sodium chloride sodium salt is added to the standing water to obtain a stock solution. Electrolyzing the undiluted solution into primary produced water, diluting the primary produced water to produce sterilized water containing hypochlorous acid (HCLO), the sterilized water concentration force ^s 201～600Ppm of hypochlorous acid contained in, so that the pH is 5.6 to 7, undiluted composition conditions including the amount of the sodium chloride, then set the electrolysis conditions and dilution conditions, the After preparing the stock solution according to the stock solution composition conditions, electrolyzing the stock solution according to the electrolysis conditions, and then diluting the primary product water generated by the electrolysis according to the dilution conditions. In the process, the primary product water is injected into the dilution water through a predetermined discharge pipe. With the time of injection, the tip position of the discharge pipe is intended to be equal to or less than the water level of the dilution water.

[0033] Further, in the method for producing sterilizing water according to the present invention, the pH of the stock solution is calculated using the solubility of carbon dioxide and the concentration of carbon dioxide in the atmosphere at the temperature at which the stock solution is prepared, The stock solution composition conditions, the electrolysis conditions, and the dilution conditions are set using the calculated values.

[0034] Further, the method for producing sterilizing water according to the present invention is set to 400 to 6 OOppm instead of 201 to 600ppm. [0035] The method for producing sterilizing water according to the present invention is 6.3 to 6.7 instead of 5.6 to 7.

[0036] The method for producing sterilizing water according to the present invention is 5.6 to 6.3 instead of 5.6 to 7.

[0037] Further, the sterilizing water generating apparatus according to the present invention is an apparatus for generating sterilizing water containing hypochlorous acid (HCLO) by electrolyzing a stock solution in an electrolytic cell as described in claim 13. A stock solution tank for storing the stock solution, an electrolytic bath connected to the stock solution tank, a discharge pipe connected to the electrolytic bath, and a dilution water tank storing dilution water. The dilution water tank is positioned relative to the tip of the discharge pipe so that the tip of the discharge pipe is below the level of the dilution water stored in the dilution water tank. It produces sterilized water for the purpose of sterilizing periodontal disease bacteria living in pockets.

[0038] Further, the sterilizing water generating device according to the present invention, as described in claim 14, is a sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria that inhabit the periodontal pocket. In addition, a stock solution tank that stores a stock solution in which only sodium chloride is added to the passing water obtained by passing water through a reverse osmosis membrane, and an electrolysis of the stock solution connected to the stock solution tank. An electrolytic cell that produces primary product water and dilution water that dilutes the primary product water that is discharged through a discharge pipe that is connected to the electrolytic tank to produce sterilization water is stored in advance. A diluting water tank in which the discharge pipe is relatively positioned so that the tip of the diluting water is below the level of the diluting water, and the concentration power of the hypochlorous acid (HCLO) in the sterilizing water is 201 to The amount of sodium chloride added is 600 ppm and the pH is 5.6-7. Because, it is as defined prescribed or dilution conditions operating conditions of the electrolytic cell.

[0039] In addition, the sterilizing water generating device according to the present invention, as described in claim 15, is a sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria that inhabit the periodontal pocket. In addition, a stock solution tank for storing a stock solution in which pure water is added to salt water obtained by leaving pure water in the atmosphere for a predetermined period, and a stock solution tank connected to the stock solution tank to electrically connect the stock solution. An electrolytic cell that decomposes to produce primary product water and dilution water that dilutes the primary product water discharged through a discharge pipe that is connected to the electrolytic cell to produce sterilization water are stored in advance. A dilution water tank in which the discharge pipe is relatively positioned so that the tip of the discharge pipe is below the level of the dilution water, and the hypochlorous acid in the sterilizing water (

The amount of sodium chloride added is determined so that the concentration power of HCLO is 201 to 600 ppm and the pH is 5.6 to 7, the operating conditions of the electrolytic cell are determined, or the dilution conditions are determined.

[0040] In addition, the sterilizing water generator according to the present invention is not limited to the above-mentioned 201-600ppm, but 400-6

OOppm.

[0041] Further, the sterilizing water generator according to the present invention is 6.3 to 6.7 instead of 5.6 to 7.

[0042] The sterilizing water generator according to the present invention is 5.6 to 6.3 instead of 5.6 to 7.

[0043] (Invention related to sterilized water)

[0044] The pathogens of periodontitis are mainly anaerobic gram-negative bacilli and spirochetes. Specifically, the gram-negative bacilli, Borphyromonas gingivalis (P. gingivalis), Actinobacillus actinomycetemcomitans (hereinafter "", A.actinomycetemc omitans), Prevotella intermedia, Bacteroides forsythus, Gram-negative short bacterium Eikenella corrodens, gram-negative bacteria, Campylobacter rectus, and Spirocheta, Treponema denticola (T.denticola).

[0045] The applicant of the present invention has conducted such a periodontopathic bacterium while performing laser treatment using an Er: YAG laser that generates a laser with a transpiration function of a wavelength of 2.94 μm and treatment with antibiotics. I learned how difficult it was to kill them, and researched the fact that it was impossible to use the sterilizing power of hypochlorous acid (HCLO), which has been known so far.

[0046] However, as already described, since periodontal disease bacteria live deep in the periodontal pocket as subgingival plaque, they contain known sterilized water containing hypochlorous acid (HCLO). At the same time, the gingival plaque and the organic matter in the oral cavity are not only oxidized, but when injected directly into the periodontal pocket, the organic matter and the periodontal pocket accumulated in the periodontal pocket are removed. Bactericidal power is consumed by acidifying other cells that inhabit. In any case, it was found that hypochlorous acid (HCLO) that preserved bactericidal power could not be fed deep into the periodontal pocket.

[0047] Therefore, if the concentration of hypochlorous acid (HCLO) is increased, the present applicant can prevent periodontopathic fungi even if the acidity gradually decreases before reaching the depth of the periodontal pocket. The R & D perspective was shifted to increasing the concentration of hypochlorous acid (HCLO), thinking it could be killed.

However, a high concentration of hypochlorous acid water exceeding 200 ppm has not been disclosed at the time of this application.

That is, in order to measure the concentration of hypochlorous acid (HCLO), for example, there is a residual chlorine meter sold by Organo Corporation under the trade name “Residual chlorine test paper Aqua Check”. Is 0, 0.1, 0.5, 1. O (mgZL). If the concentration is 1 ppm or more, the concentration cannot be measured. Similarly, “Digital Residual Chlorine Analyzer HI 95 Series” is 0.00 to 5. OOmg ZL, “Pocket Residual Chlorine Meter (manufactured by NOCK)” is O. 02 to 2. OOmg / L, “Portable Residual Chlorine” “Total OR-52” is 0.05 to 2. OOmg / L, and “Portable water quality meter WA-1” is 0.05 to 2. OOmgZL. In addition, products sold under the product name “Residual Chlorine Meter CR-200” by HORIBA Advanced Dotetano Co., Ltd. have a measuring range of 0 to 2. OmgZL, Emkeichi Ltd. “Residual Chlorine Meter C- The products sold under the trade name “201 (completely waterproof)” are 0.01 to 6. OmgZL, and the upper limit of measurement is mostly 5 to 6 ppm.

[0050] By the way, what is sold under the product name “Residual chlorine measuring device RC-7Z” by Tech Jam Co., Ltd. has a measurement range of 10 to 200 mgZL, and from Iwaki Co., Ltd. Type) The product sold under the trade name CL-50HJ is 20-200mgZL, sold by Toko Chemical Research Co., Ltd. under the trade name A QUALYTIC (made in Germany)! The “concentration meter” has a measurement range of high-concentration effective chlorine of 0 to 200 mg ZL, but 200 ppm is still the upper limit of measurement.

[0051] Furthermore, Bayer Medical Co., Ltd. sells a test strip under the product name "Nissan Aqua Check HC" as a high-concentration test strip. , 100, 200, 400, 600 mgZL ”is explained to have a high range S (http: 〃 www.aquachek.net/aq—08b06.html, December 14, 2005 Internet search ), “This method considers the measurement of high concentration sodium hypochlorite (strong alkalinity) (omitted) and uses a chromogen that has little effect on pH.” (Same as above) Regarding chlorine, it measures the concentration of sodium hypochlorite (strong alkaline), not hypochlorous acid (HCLO)! /.

[0052] In addition, Tsumoto Rii Sangyo Sangyo Co., Ltd. is sold under the trade name “Simple Water Quality Test Kit Simple Pack” and says that “Residual chlorine 300 ClO300” can be measured in the concentration range of 50 to 300 mgZL. , But the explanation is made (http://www.tsumoto-rika.co.jp/simple-pac k.htm, Internet search on December 16, 2005), the measurement object is hypochlorous acid (HCLO) However, it is clear that the product name is that it is hypochlorite ion (CLO).

[0053] Similarly, Endo Science Co., Ltd. sells the product under the trade name “Pack Test WAR—CIO (C)”. Residual chlorine (high concentration) 5 to: LOOOO mgZL concentration range It is explained that it can be measured by (http://www.endokagaku.co.jp/shop/packtest/pack test_kind.html, Internet search on December 16, 2005), but the measurement target is hypochlorite. It is clear from the trade name that it is a hypochlorite ion (CLO-), not an acid (H CLO).

[0054] Thus, when the concentration of hypochlorous acid (HCLO) exceeds 200 ppm, there is no device capable of measuring the concentration at the time of filing, that is, hypochlorous acid exceeding 200 ppm. There is no acid water, and it is a known proof that it is not a known substance.

[0055] And, above all, hypochlorous acid water for use in killing periodontal disease bacteria that reside in the periodontal pocket has been completely disclosed in the prior art, as described above. is there.

[0056] The reason why the concentration of hypochlorous acid (HCLO) must be increased in the sterilized water according to the present invention is as follows.

[0057] (a) Even if the acid squid is consumed gradually before reaching the depth of the periodontal pocket, it must retain the bactericidal power enough to kill the periodontal disease bacteria.

[0058] (b) Sterilizing over a long period of time, for example, 60 seconds or more, produces the end result of sending hundreds of millions of periodontal disease bacteria into the body (intravascular). 40 at the longest It must be killed within seconds (according to the applicant's clinical trials, the time required for sterilization when using 200 ppm), preferably within 20 seconds (also 300 ppm), more preferably within 10 seconds (also 400 ppm). The sterilization time clarified by clinical trials is the time to kill all periodontal disease bacteria present on the entire circumference of one tooth, as described in Examples.

[0059] (c) 300-400 species of bacteria in the dental plaque in the oral cavity grow in a parasitic manner while maintaining a certain balance, forming a bacterial flora (so), which is due to some cause In other words, if the bacteria are replaced with other bacteria, or if a small number of bacteria are abnormally increased, a change in the bacterial flora called a bacterial change phenomenon occurs. In other words, if some periodontal disease bacteria that live deep in the periodontal pocket, for example, T. denticola, survive without being sterilized, a fungal change occurs and T. denticola grows rapidly. In order to prevent this situation, all periodontal disease bacteria living in the periodontal pocket must be sterilized.

[0060] The sterilizing water according to the present invention has a hypochlorous acid (HCLO) concentration of 201 to 600 ppm and a pH of 5.

In addition to 6-7, it is intended for the sterilization of periodontal disease bacteria that inhabit the periodontal pocket. In use, the sterilizing water is injected into the periodontal pocket.

[0061] In this way, the sterilizing water gradually loses the sterilizing power due to oxidation of organic matter and other bacterial cells, but only sterilizes the periodontal disease bacteria when it reaches deep in the periodontal pocket. Because it retains acidity, periodontal disease bacteria can be killed reliably. Of course, tooth demineralization is also prevented at that time.

[0062] By the way, the reason why the concentration was set to 201 ppm or more is that it is difficult to achieve the above (a) to (c) at a concentration of 200 ppm or less. In order to achieve a) to (c), there is a force that is unnecessary concentration.

[0063] Here, when the concentration of hypochlorous acid (HCLO) is set to 300 to 600 ppm, periodontal disease bacteria can be completely sterilized within a few seconds, and when 400 to 600 ppm is set, it is instantly completely sterilized. It can be done.

[0064] When producing the sterilized water according to the present invention by adding hydrochloric acid or acetic acid, the stimulant substance generated at the same time as the production gives odor and taste to stimulate the patient, so hypochlorous acid ( The concentration of HCLO) should be 500 ppm or less, and more preferably 400 ppm or less.

[0065] In injecting the sterilizing water according to the present invention into the periodontal pocket, the Er: YAG laser By irradiating and scaling, the nanofilm existing deep in the periodontal pocket is removed in advance. Incidentally, it has become clear from the applicant's clinical trial that periodontal disease bacteria cannot be killed only by irradiation with an Er: YAG laser.

[0066] The sterilizing water according to the present invention is not limited to the use only for the sterilization of periodontal disease bacteria inhabiting the periodontal pocket, and can be applied to the sterilization of every part of the human body and every part of the human body. is there. The application target is not limited to the human body.

[0067] It should be noted that if the dissolved gas is removed as will be described later, it is possible to prevent an increase in bleeding from the wound due to the foaming phenomenon and prevent germs from entering the body.

(Invention relating to method and apparatus for producing sterilizing water)

[0069] In producing the sterilizing water according to the present invention, as long as the sterilizing water is injected into the periodontal pocket, maintaining the pH without decalcifying the teeth is an absolute condition. In H5.5, the dentin is decalcified at pH 6.2 and the deciduous teeth are decalcified at pH 6.2, so the pH range is limited to PH5.6 or higher. In addition, assuming that dentin is exposed without being covered with enamel, the pH range is limited to pH 6.3 or higher.

[0070] On the other hand, chlorine is a chemical substance that changes its form, such as chlorine gas, hypochlorous acid (HCLO), and hypochlorite ion (CLO-), depending on the pH environment, and is toxic to chlorine gas. This is well known, and when dilution is performed to adjust the concentration, the pH changes and the form of chlorine changes.

[0071] Specifically, in order to contain chlorine in a sufficient ratio in an aqueous solution in the form of hypochlorous acid (HCLO), pH 2.2 to pH 7 (as a guide, hypochlorous acid in the percentage of effective chlorine present) Acid (HCLO) of about 80% or more), desirably pH 2.8 to pH 6.7 (hypochlorous acid (HCLO) of about 90% or more in the percentage of available chlorine).

[0072] Therefore, in producing highly concentrated hypochlorous acid water as sterilizing water, the pH of the sterilizing water is 5.6 to 7 (6.3 to 7), preferably 5.6 to 6. 7 or less (6.3 or more and 6. 7 or less) must be diluted so that it is very strictly within the range! Along with /, the sterilized water after dilution must of course have the desired high concentration. In other words, a very difficult problem arises in that it is necessary to take into account the concentration variation of hypochlorous acid (HCLO) due to dilution while accurately controlling the pH after dilution. [0073] On the other hand, known methods for electrolyzing the raw stock solution using sodium chloride (NaCL), acid and water as the stock solution are hand disinfection, fruit and vegetable disinfection, and sterilization of food production lines. Strict pH control is not necessary because it is used for disinfection of bathrooms, disinfection of pool water, bleach, and disinfection of wastewater after sewage treatment. Rather, the pH does not work in a hygienic range, for example, about 4-6, so a large amount of sterilizing water is required.

[0074] Therefore, in the known method described above, during electrolysis, the inside of the electrolytic cell is adjusted to a strongly acidic side (for example, about pH 1), and the water pipe is joined to the discharge pipe connected to the electrolytic cell. By diluting, the strongly acidic water that came out of the electrolytic cell was diluted about 10 ³ to 10 ⁵ times to obtain a large amount of hypochlorous acid water of several tens of ppm.

[0075] In such a method, although the pH of the generated hypochlorous acid water is in the range of 4 to 6 described above, it is a large amount of dilution. In terms of accuracy, it is impossible to produce nitrous acid, and the concentration of hypochlorous acid is of course as low as several tens of ppm.

[0076] Thus, the method for producing sterilizing water in which the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7! / ヽ is 6.3 to 7 is the conventional technique. Not revealed at all.

[0077] In addition to this, to produce sterilized water so that the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm, the pH is 5.6 to 7 or the pH is 6.3 to 7 There are inherently difficult reasons.

[0078] That is, as long as high concentration hypochlorous acid water is generated, it is naturally necessary to lower the dilution rate. However, when the dilution rate is small, the water feeding speed (water feeding amount) by the pump of the diluting water becomes small. A pulsating flow is generated, making it difficult to produce homogeneous hypochlorous acid water.

[0079] In the past, strong acid water having a pH of about 1 was diluted in a large amount in the pipe, so there is little risk of chlorine gas being generated, and even if chlorine gas is temporarily generated and volatilized, Therefore, powerful force that needs to be concerned about leakage to the outside. If the pump cannot be used with a small amount of dilution, it will not be possible to dilute in the piping, and in the unlikely event of electrolysis trouble, that is, overcurrent will occur. If a trouble occurs in which the pH shifts to the acidic side and chlorine gas is generated due to the flow or unnatural force of the stock solution, the safety measures must be taken. Arise. [0080] It is very difficult to set the stock solution composition and the operating conditions of the electrolytic cell, and it is very difficult to set the stock solution composition and the electrolytic cell operating conditions. In reality, it lacks reality.

Therefore, the present applicant has obtained the following new knowledge regarding a method for producing sterilizing water that can be produced safely and homogeneously while satisfying the strict and demands regarding concentration and pH.

[0082] That is, in the method for producing sterilizing water according to the present invention, primary water obtained by electrolyzing a stock solution obtained by adding sodium chloride and an acid to water is diluted to produce sterilizing water. First, the concentration of hypochlorous acid contained in the sterilized water is 201-600ppm, and the pH is 5.6-7 or 6.3-7. Parameters (hereinafter referred to as stock solution composition conditions), parameters related to electrolysis such as voltage and current values (hereinafter referred to as electrolysis conditions), and dilution factors and dilution water types and parameters related to dilution (hereinafter referred to as dilution conditions) ) Is set.

[0083] Since the acid functions as a pH adjuster, any acid such as hydrochloric acid or acetic acid can be used.

[0084] The water that is a component of the stock solution can be well water, tap water, or the like, and it is not necessary to use pure water. However, it goes without saying that pure water that does not contain calcium ions, magnesium ions, etc. should be used to prevent electrode damage and electrode reaction deterioration in the electrolytic cell.

[0085] The same applies to the dilution water, and well water, tap water, pure water, or the like can be used. The dilution water is appropriately set so that the pH of the produced sterilization water is within the above-mentioned range.

[0086] After preparing the stock solution according to the set stock solution composition conditions, this is stored in the stock solution tank

Next, the stock solution is put in an electrolytic cell according to electrolysis conditions, and the stock solution is electrolyzed.

[0088] Next, primary generated water generated in the electrolytic cell is injected into diluted water stored in advance in a diluted water tank through a discharge pipe connected to the electrolytic cell.

Here, the installation position of the dilution water tank is relatively positioned so that the tip position of the discharge pipe is equal to or lower than the level of the dilution water stored in the dilution water tank. Therefore, if the primary product water is injected into the dilution water through the discharge pipe, it is injected in a non-contact state with air.

[0091] In this way, even if chlorine gas is generated due to the mixing ratio of the stock solution and the operating conditions of the electrolytic cell being different from the design values, the chlorine gas has a neutral pH environment. In dilute water close to, the form changes to hypochlorous acid (HCLO), and there is no fear of volatilizing into the air as chlorine gas.

Here, the dilution water is measured in advance so that the primary product water is diluted at the dilution factor set in the dilution condition, and then stored in the dilution water tank, and the dilution water corresponds to the dilution factor. If an amount of primary product water has been injected into the dilution water tank, the injection operation is terminated.

[0093] By doing so, hypochlorous acid water having a designed concentration and pH can be generated safely and homogeneously.

[0094] The dilution factor should be determined according to the required concentration of hypochlorous acid (HCLO)! For example, if hypochlorous acid water with a concentration of 400 ppm is required, the stock solution composition conditions and electrolysis conditions should be set appropriately so that the concentration of hypochlorous acid (HCLO) in the primary product water is 4000 ppm. At the same time, the dilution factor should be 10.

[0095] (Invention relating to sterilized water and its production method-no addition of hydrochloric acid or acetic acid)

[0096] According to the method for producing sterilized water described above, sterilized water having a concentration of hypochlorous acid (HCLO) of 201 to 600 ppm and a pH of 5.6 to 7 or 6.3 to 7 can be produced. According to such bactericidal water, it becomes possible to sterilize the periodontal disease bacteria that live in the periodontal pocket in a few seconds per tooth.

[0097] However, in the method of generating powerful sterilizing water, it is necessary to add hydrochloric acid or acetic acid to the stock solution, which makes it difficult to control pH, and in combination with components contained in water from the beginning. In addition to hypochlorous acid (HCLO), various substances, especially stimulants that stimulate the senses of taste and smell, are produced, causing discomfort to the patient.

[0098] Therefore, when the sterilized water produced by the production method described above is used in the oral cavity, it is desirable that the upper limit is 500 ppm, preferably 400 ppm.

[0099] Even at a strong concentration, periodontal disease bacteria that inhabit the periodontal pocket can be killed in a few seconds per tooth, but the patient's discomfort related to odor and taste can be further reduced. Or, as a result of further research by the applicant, focusing on whether or not the sterilizing water generation process including pH control could be further simplified, the company succeeded in developing an innovative sterilizing water manufacturing method. According to such a method for producing sterilizing water, the addition of hydrochloric acid or acetic acid, which was considered essential for the production of hypochlorous acid water, becomes unnecessary, and the production of stimulating substances is also prevented accordingly. Increasing the concentration of hypochlorous acid (HCLO) to 600 ppm does not cause discomfort to the patient regarding odor and taste.

[0100] In the method for producing sterilizing water according to claim 7 and claim 8, the raw solution composition conditions, electrolysis conditions, and dilution conditions are set in substantially the same procedure as in the invention according to claim 6. In the invention according to claim 7, water is passed through a reverse osmosis membrane, and the stock solution is prepared by adding only sodium chloride to the passing water. In the invention according to claim 8, pure water is left in the atmosphere for a predetermined period. The stock solution is prepared by adding only sodium chloride to the standing water, and no acid such as hydrochloric acid or acetic acid is added. In addition, the main component composition condition is the amount of sodium chloride added.

[0101] The reverse osmosis membrane has a pore size of lmm / million, so it allows water molecules that are slightly smaller than it to pass, but larger molecules are not allowed to pass, and ions are not allowed to pass. Since it also has the function of electrical exclusion, even substances that are smaller than 1 millionth of an inch, such as sodium ions, are almost completely removed, just like other ions.

[0102] Such a reverse osmosis membrane was originally studied as a means of seawater desalination and is now widely used in the production of pure water and ultrapure water for industrial use such as semiconductor cleaning.

[0103] However, even with a reverse osmosis membrane having such a high water purification function, gases such as oxygen and carbon dioxide, which are dissolved in water, which are difficult to prevent the passage of gas, are not suitable for reverse osmosis membranes. pass

[0104] Therefore, the pH requirement is strict! / In the process, dissolved gas is often removed by degassing prior to reverse osmosis. In addition, carbon dioxide in the atmosphere dissolves quickly and easily into the pure water produced.

[0105] The present applicant focused on whether such properties relating to reverse osmosis membranes and pure water can be used in reverse, and produced pure water by irrigating tap water with a reverse osmosis membrane. Repeated.

[0106] As a result, although the pH of tap water is about 6-8, there is considerable variation nationwide. However, the pH of the water that passed through the reverse osmosis membrane was approximately 5-6.

[0107] This is because tap water contains various substances including minerals, but the pH of the water itself varies, but the ions that contribute to the pH are almost completely removed by the reverse osmosis membrane. It is thought that the reason is that only the pH contribution due to carbon dioxide was realized.

[0108] If this property is used, sterilized water containing high concentration of hypochlorous acid (HCLO) can be generated without adding hydrochloric acid, acetic acid and! However, as a result of further research, the present applicant has made the above-described invention.

[0109] That is, the pH of water that has passed through a reverse osmosis membrane or pure water that has been left in the atmosphere for a certain period of time depends on the diacid-carbon in the atmosphere, and it does not bother the addition of acids such as hydrochloric acid and acetic acid. In both cases, it is possible to obtain a weakly acidic stock solution in a state where the pH is almost determined and safely, and since the force and pH value are known, the electrolysis conditions and dilution conditions can be easily set. wear.

[0110] And most of all, the dissolved substances contained in tap water and well water are removed in advance with a reverse osmosis membrane, or removed because they are pure water, and no hydrochloric acid or acetic acid is added. It is possible to produce tasteless and odorless sterilized water, and as a result, even if the concentration of hypochlorous acid (HCLO) is 500 ppm to 600 ppm, it will cause any discomfort to the patient and will be several seconds per tooth. It has an epoch-making effect that it can completely kill periodontal disease bacteria in a short time.

[0111] The procedure for generating sterilizing water after electrolysis is the same as that of the invention according to claim 6, and therefore detailed description thereof is omitted here.

[0112] (Degassing)

[0113] Although the sterilized water produced by each of the production methods described above may not be used as the sterilized water according to the present invention, the water produced by injecting the primary produced water into the diluted water (hereinafter, secondary produced water) By removing dissolved gas from the water and using this as sterilizing water, it is possible to prevent foaming in the periodontal pocket and more reliably prevent the periodontal bacteria from being sent into the body (intravascular). Become.

[0114] That is, when the stock solution is electrolyzed, oxygen and hydrogen are naturally generated in the electrolytic cell. And these remain in water as dissolved gas. Especially oxygen is dissolved oxygen It tends to remain.

[0115] In this case, there is no problem if the concentration of dissolved gas is low, but if the concentration of dissolved gas increases due to the electrolysis operating conditions, etc., sterilizing water (secondary product water) is poured into the periodontal pocket. When entering, the dissolved oxygen becomes gas in the periodontal pocket, causing a foaming phenomenon, which stimulates the capillaries in the periodontal pocket and increases bleeding.

[0116] In such a situation, there is a concern that some periodontal bacteria are sent into the body (intravascular) while disinfecting periodontal bacteria.

[0117] However, if the tertiary generated water obtained by removing the dissolved gas from the secondary generated water is used as sterilizing water, there is no fear of foaming when injected into the periodontal pocket.

[0118] In order to remove the dissolved gas, the tertiary product water tank that stores the tertiary product water as sterilizing water is connected to the dilution water tank, and between the tertiary product water tank and the dilution water tank. If there is a means for removing dissolved gas, it will be necessary.

[0119] As the dissolved gas removal means, for example, a hollow fiber membrane deaeration module sold by Dainippon Ink & Chemicals, Inc. can be used. If a powerful hollow fiber membrane deaeration module is used, Dissolved oxygen can be degassed to the lppb level, and foaming in the periodontal pocket can be reliably prevented. Brief Description of Drawings

FIG. 1 is a schematic diagram showing a sterilizing water generator according to a first embodiment.

FIG. 2 is a schematic view showing a sterilizing water generator according to a modification.

FIG. 3 is a graph showing the effect of sterilizing water according to the present embodiment.

FIG. 4 is a graph showing the effect of sterilizing water according to the present embodiment.

FIG. 5 is a diagram showing the difference in action and effect between sterilization methods (before sterilization).

[Fig. 6] A diagram showing the difference in action and effect of the sterilization method (after scaling).

FIG. 7 is a diagram showing the difference in action and effect of the sterilization method (after laser treatment).

FIG. 8 is a diagram showing the difference in action and effect by the sterilization method (high concentration hypochlorous acid water).

FIG. 9 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to the present embodiment is used for a patient with severe periodontal disease.

[Fig. 10] A diagram showing the state after treatment. FIG. 11 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to the present embodiment is used for a patient with severe periodontal disease.

圆 12] The same figure after treatment.

FIG. 13 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[14] The same figure after treatment.

FIG. 15 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[16] The same figure after treatment.

FIG. 17 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

圆 18] The same figure after treatment.

FIG. 19 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[20] The same figure after treatment.

FIG. 21 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[22] The same figure after treatment.

FIG. 23 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[24] The same figure after treatment.

FIG. 25 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[26] The same figure after treatment.

FIG. 27 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

圆 28] The same figure after treatment.

[FIG. 29] Using sterilized water (high concentration hypochlorous acid water) according to this embodiment for patients with severe periodontal disease The figure which showed the mode before treatment in the case of a case.

[30] The same figure after treatment.

FIG. 31 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to the present embodiment is used for a patient with severe periodontal disease.

圆 32] The same figure after treatment.

FIG. 33 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[34] The same figure after treatment.

FIG. 35 is a view showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

[36] The same figure after treatment.

FIG. 37 is a diagram showing a state before treatment when sterilizing water (high concentration hypochlorous acid water) according to this embodiment is used for a patient with severe periodontal disease.

圆 38] The same figure after treatment.

FIG. 39 is a schematic view showing a sterilizing water generator according to a second embodiment.

圆 40] Schematic showing a sterilizing water generator according to a modification.

FIG. 41 is a view showing a state after treatment when sterilized water having a concentration of hypochlorous acid (HCLO) of 200 ppm and a pH of 6.3 to 6.7 is used.

[42] A diagram showing a state after treatment when the same sterilized water is used.

[43] A diagram showing a state after treatment when the same sterilized water is used.

[44] A diagram showing a state after treatment when the same sterilized water is used.

圆 45] A diagram showing the state after treatment when similar sterilized water is used.

[46] A diagram showing the state after treatment when the same sterilized water is used.

[47] A diagram showing a state after treatment when the same sterilized water is used.

FIG. 48 is a diagram showing a state after treatment when sterilized water having a concentration of hypochlorous acid (HCLO) of 500 ppm and a pH of 6.3 to 6.7 is used.

[49] A diagram showing a state after treatment when the same sterilized water is used.

Explanation of symbols 1, 21 Disinfection water generator

2, 22 Stock solution

3 Stock solution tank

5 Electrolysis tank

6 Discharge pipe

7, 27 Diluted water

8 Dilution water tank

9 Water level sensor

11 Deaeration module

14 Tertiary water tank

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, embodiments of sterilizing water, a method for producing the same, and a production apparatus according to the present invention will be described with reference to the accompanying drawings. Note that parts that are substantially the same as those of the prior art are denoted by the same reference numerals and description thereof is omitted.

[0123] (First embodiment)

[0124] The sterilized water according to the present embodiment has a concentration of hypochlorous acid (HCLO) of 300 to 400 ppm, a pH of 6.3 to 6.7, and a periodontal disease bacterium that inhabits the periodontal pocket. It is intended for sterilization.

[0125] Here, 300 ppm or more is not only to retain the oxidizing power to kill periodontal bacteria when reaching deep in the periodontal pocket, but also to completely kill periodontal bacteria within a few seconds The reason for setting it to 400 ppm or less is to alleviate irritation to the oral cavity.

[0126] In order to treat periodontal disease using the sterilized water according to the present embodiment, first, the biofilm existing deep in the periodontal pocket is obtained by performing irradiation and scaling of an Er: YAG laser. Remove in advance.

[0127] Next, for example, an irrigation chip (cleaning chip) is attached to an ultrasonic scaler, and the tip of the irrigation chip is inserted into the periodontal pocket to inject the sterilizing water according to the present embodiment. . Here, while removing the biofilm with an ultrasonic scaler, Bacterial water can be injected.

In this way, when the sterilizing water according to the present embodiment reaches the depth of the periodontal pocket while gradually sterilizing the sterilizing power due to oxidation of organic matter and other bacteria in the periodontal pocket. With this, it is possible to hold an acid scent that can sterilize periodontal disease bacteria and to kill periodontal disease bacteria. Of course, tooth decalcification can also be prevented beforehand.

[0129] Power! In addition, according to the sterilizing water according to the present embodiment, the concentration of hypochlorous acid (HCLO) is adjusted to 300 to 400 ppm, so that the periodontal disease bacteria that live deep in the periodontal pocket can be detected within a few seconds (400 ppm). It can be completely sterilized instantaneously at nearby concentrations.

[0130] Incidentally, it has been conventionally said that it is difficult to kill periodontal disease bacteria in the periodontal pocket. In other words, Treponema denticola, which is classified as spirochete, has been researched since the time of Dr. Hideyo Noro. Recently, Td enticola has an action to suppress immune responses It has been elucidated that no antibodies are produced. In other words, T. denticola has an immunosuppressive factor, and this immunosuppressive factor inhibits the antigen recognition function of macrophages. Therefore, even if T. denticola is present, antibodies against T. denticola are not generated. Not only is T. denticola's immunosuppressive factor effective in suppressing the immune response against other periodontal pathogens, and as a result, T. denticola, along with other periodontal pathogens, is contained in the periodontal pocket. Increase rapidly.

[0131] In that sense, the sterilizing water according to this embodiment that can instantly sterilize the periodontal disease bacteria in the periodontal pocket is truly epoch-making, and its action and effect are remarkable as described in the examples described later. In a word.

[0132] Since the periodontal disease bacteria that were said to be difficult to kill can be completely sterilized, not only the supragingival plaque but also other subgingival plaques that inhabit the periodontal pocket. Naturally, it can be completely sterilized.

[0133] For example, Streptococcus sanguis, which is the most common dental plaque on the gingival margin and causes subacute bacterial endocarditis, and the bacterial heart Streptococcus mitis, the causative agent of membrane inflammation, can also be killed.

Next, FIG. 1 shows a production apparatus for producing sterilizing water according to this embodiment. As can be seen from the figure, the sterilizing water generator 1 according to this embodiment includes a stock solution tank 3 that stores a stock solution 2, a stroke pump 4 that is connected to the stock solution tank, and the stroke pump. An electrolyzer 5 connected to the electrolyzer, a discharge pipe 6 connected to the electrolyzer, a diluting water tank 8 storing diluting water 7, and a water level measuring means for measuring the water level in the diluting water tank The dilution water tank 8 is installed at the tip of the discharge pipe 6 so that the tip of the discharge pipe 6 is equal to or lower than the water level of the dilution water 7 stored in the dilution water tank 8. The position is relatively positioned.

[0136] Stock solution 2 can be composed of, for example, sodium chloride sodium (NaCL), hydrochloric acid (HCL), and water, but hydrochloric acid functions as a pH adjuster, so any acid such as acetic acid can be used. wear.

[0137] As the electrolytic cell 5, for example, an electrolytic cell used in an electrolytic neutral water generator sold by Sakai Engineering Co., Ltd. under the trade name "Epiosuko" can be used.

[0138] The water level sensor 9 may be appropriately selected, for example, an ultrasonic sensor or an electrode type sensor.

[0139] As dilution water 7, well water, tap water, pure water or any other water can be used. The pH is appropriately selected so that the pH of the sterilized water to be generated is in the above-mentioned range.

[0140] The production apparatus 1 according to the present embodiment further includes a deaeration module 11 in which the water injection side is communicated with the secondary production water 10 in which the primary production water is diluted with the dilution water 7 in the dilution water tank 8. The deaeration module is adapted to remove dissolved oxygen in the secondary product water 10 by decompression by the vacuum pump 12, and the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 10. Is provided with a tertiary production water tank 14 for storing as a sterilizing water 13.

[0141] As the degassing module 11, for example, a hollow fiber membrane degassing module sold by Dainippon Ink & Chemicals, Inc. can be used. In particular, a degassing module for chemicals that uses polytetrafluoroethylene hollow fiber as the degassing membrane and all wetted parts are fluorocoating is desirable.

[0142] It should be noted that the tubes used in the generating device 1 or the electromagnetic valve provided as necessary are likely to be deteriorated by acid with high-concentration hypochlorous acid (HCLO) and are therefore formed with fluorine. Is desirable. [0143] In order to produce the sterilized water 13 using the sterilized water generator 1 according to this embodiment, first, the concentration of hypochlorous acid (HCLO) in the secondary produced water is 300 to 400 ppm, pH The composition of stock solution 2, its blending ratio, operating conditions during electrolysis (for example, voltage value and current value) and dilution conditions (dilution ratio and pH of diluted water) At the same time, the blended stock solution 2 is stored in the stock solution tank 3.

[0144] Next, while the stock solution 2 is sent to the electrolytic cell 5 by the stroke pump 4, the electrolytic cell 5 is operated under the predetermined operating conditions, and the stock solution 2 is electrolyzed.

[0145] Next, primary generated water generated in the electrolytic cell 5 is injected into the diluted water 7 stored in the diluted water tank 8 in advance through the discharge pipe 6 connected to the electrolytic cell. To do.

Here, the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 7 stored in the dilution water tank 8. is there.

[0147] Therefore, if the primary water is injected into the dilution water 7 through the discharge pipe 6, it is injected in a non-contact state with the air.

[0148] In this way, even if the mixing ratio of the stock solution 2 and the operating conditions of the electrolytic cell 5 are different from the design values, and chlorine gas is generated due to this, the chlorine gas is In the diluting water 7 that is close to neutral, its form changes to hypochlorous acid (HCLO), and there is no concern of vaporizing into the air as chlorine gas.

[0149] The amount of the dilution water 7 is measured in advance so that the primary product water is diluted at the dilution rate, and the measured water level increase value obtained by the water level sensor 9 is a target corresponding to the dilution rate. When the water level rise value is reached, the primary water injection through the discharge pipe 6 is terminated.

[0150] By doing this, it is possible to produce secondary produced water 10 having the designed concentration and pH.

[0151] Next, the secondary product water 10 is passed through the deaeration module 11 to generate tertiary product water from which dissolved gas, particularly dissolved oxygen, has been removed. Store in tank 14.

[0152] As described above, according to the method and apparatus 1 for producing sterilizing water according to the present embodiment, the dissolved gas is removed from the secondary product water 10 to produce the tertiary product water 13, which is Since it is sterilized water, it prevents foaming in the periodontal pocket and sends periodontal disease bacteria into the body (intravascular). Therefore, it becomes possible to prevent the situation from occurring.

[0153] In this embodiment, the dissolved gas in the secondary product water 10 is removed using the degassing module 11. However, the concentration of the dissolved gas in the secondary product water 10 is low, so that the foaming phenomenon occurs. If there is no concern that this will occur, the process of removing dissolved gas can be omitted. In such a case, the secondary product water 10 is sterilized water.

FIG. 2 is a diagram showing the generator la used when the dissolved gas removal step is omitted. The degassing module 11, the vacuum pump 12, and the tertiary product water tank 14 are omitted from the generator 1.

[0154] In this embodiment, the force using the water level sensor 9 as the water level measuring means. Instead, for example, a scale is attached to the dilution water tank 8 in advance, and the water level is measured using this scale as a guide. It does n’t work. Furthermore, the water level measurement means may be omitted and the measurement may be performed separately.

[0155] In the present embodiment, the example in which the sterilizing water is generated so that the pH is 6.3 to 6.7 or 6.3 to 7 has been described, but the pH is 5.6 to 6.3. The same procedure can be followed for the production of sterilized water.

Further, in the present embodiment, the sterilizing water, its generating method and generating device for the purpose of sterilizing periodontal disease bacteria that inhabits in the periodontal pocket have been described. (HCLO) concentration is 201-500ppm and pH is 6.3-7, so it is inherently strong bactericidal and has a pH near neutral. Is unthinkable.

[0156] Therefore, the sterilizing water according to the present invention is not limited to the use only for the sterilization of periodontal disease bacteria living in the periodontal pocket, but can be applied to the sterilization of any part of the human body and any part. It is. In addition, the application target is not limited to the human body.

[0157] In particular, if the dissolved gas is removed, it is possible to prevent increased bleeding from the wound due to the foaming phenomenon and prevent germs from entering the body. As water, it becomes a very useful means.

[0158] Needless to say, the sterilizing water generating method and generating device can directly apply the generating method and generating device of the present embodiment. Example 1

[0159] (Clinical trial using sterilized water)

A clinical trial was conducted to examine the relationship between the concentration and the bactericidal level in T. denticola.

[0160] The test was performed using an Er: YAG laser (repetition rate 30pps, laser beam output energy 60m jZ pulse) to remove the biofilm of all teeth while injecting 20ppm low concentration hypochlorous acid water. Next, an irrigation chip was attached to the ultrasonic scaler, and high-concentration hypochlorous acid water was injected.

[0161] The high-concentration hypochlorous acid water had a pH of 6.5 and a concentration of 200, 300, 400 ppm. When 20 ppm of low-concentration hypochlorous acid water was used, treatment was performed before treatment, and when high-concentration hypochlorous acid water was used, after treatment. Here, the state of periodontal disease bacteria before and after treatment was determined by inserting a probe into the bottom of the periodontal pocket without touching saliva, collecting plaque and blood adhering to the root surface, and sliding it. After placing on glass and suspending in physiological saline, it was covered with a cover glass and observed with a high-resolution phase-contrast microscope at 3600 times.

[0162] Fig. 3 is a graph showing the tendency of sterilization in 10 seconds, 20 seconds, and 30 seconds, respectively. The level at which the tendency is seen, and the bactericidal level 2 indicate the level at which complete sterilization has been achieved.

[0163] As can be seen from the figure, when the time of injecting highly concentrated hypochlorous acid water into the periodontal pocket is, for example, 10 seconds, the sterilization level is less than 300 ppm of hypochlorous acid (HCLO). It was found that sterilization level 2 was obtained at a force of 400 ppm, which is almost 0, and complete sterilization was possible. Considering this graph from another perspective, for example, if the concentration is 200 ppm, complete sterilization (sterilization level 2) is 40 seconds, if the concentration is 300 ppm, 20 seconds, if the concentration is 400 ppm, complete in 10 seconds. It can be seen that sterilization is possible.

[0164] Here, the time for injecting high-concentration hypochlorous acid water into the periodontal pocket means the time for injecting per tooth, in other words, over the entire circumference of one tooth.

[0165] Fig. 4 is a graph showing the relationship between the concentration of hypochlorous acid (HCLO) and the complete sterilization time. As shown in the figure, the concentration force S200ppm is about 40%, 300ppm However, it was proved that complete sterilization was possible in 10 seconds at 20 ppm and 400 ppm. As with the above definition, the complete sterilization time is the period within a periodontal pocket distributed per tooth, in other words, around the entire circumference of one tooth. It shall mean the time required to inject hypochlorous acid water to disinfect all periodontal disease bacteria.

[0166] Incidentally, even if it can be completely sterilized over a long period of time, it has no meaning at all. This is because, for example, sterilizing over 60 seconds or more is the force that can feed hundreds of millions of periodontal disease bacteria into the body (intravascular).

Example 2

[0167] (Bactericidal effect due to different treatment methods)

The bactericidal effect due to the difference in treatment method was verified.

[0168] Figure 5 shows sterilization, Figure 6 after scaling, Figure 7 after laser treatment (30pps, 60mjZ pulse), and Figure 8 after treatment with high-concentration hypochlorous acid (400ppm). A still image is cut out from a moving image photographed through a high-resolution phase-contrast microscope (3600 times). Scaling and laser treatment were performed while injecting 20ppm low concentration hypochlorous acid water. Further, high-concentration hypochlorous acid water was poured into an ultrasonic scaler with an irrigation chip as in Example 2.

[0169] As can be seen from these figures, periodontal disease bacteria such as spirochetes were removed by scaling (Figure 6) and laser treatment (Figure 7) using 20ppm low-concentration hypochlorous acid water. It is almost the same as before the bacterium (Fig. 5), but it is almost dead (the spirochete that is a spiral bacterium is active in moving images). On the other hand, when treated with 400ppm high concentration hypochlorous acid water (Fig. 8), most of the bacteria, including periodontal disease bacteria, have been killed.

Example 3

[0170] (Results of clinical trial)

A clinical study was conducted on severe periodontal disease patients using high concentration hypochlorous acid water at 400 ppm and pH 6.5.

[0171] Fig. 9 shows the state before treatment, and Fig. 10 shows that the biofilm was removed by laser treatment, and as in Examples 2 and 3, an irrigation tip was attached to the ultrasonic scaler and high concentration hypochlorous acid was added. It shows the state after injecting water into the periodontal pocket for 10 seconds (after treatment), and the V-shift is also a still image from a moving image taken through a high-resolution phase-contrast microscope (3600 times). An image is cut out.

[0172] FIGS. 11 to 38 similarly show the pre-treatment and post-treatment states for another severe patient.

[0173] As can be seen in these figures, P.gingivalis (gram-negative bacilli) and T.denticola (spirochetes) that were inhabited in large quantities before treatment were completely treated with high-concentration hypochlorite water. The fact that it has been sterilized is powerful.

[0174] (Second Embodiment)

[0175] Next, a second embodiment will be described. Note that components that are substantially the same as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

[0176] The sterilized water according to the present embodiment has a concentration of hypochlorous acid (HCLO) of 300 to 600 ppm, a pH of 6.3 to 6.7, and a periodontopathic bacterium that resides in the periodontal pocket. It is intended for sterilization.

[0177] Here, the level of 300 ppm or more not only retains the oxidizing power to kill periodontal bacteria when reaching deep into the periodontal pocket, but also completely kills periodontal bacteria within a few seconds. The reason why it is set to 600 ppm or less is that it is not necessary to increase the concentration to sterilize the periodontal bacteria in the periodontal pocket!

[0178] To treat periodontal disease using the sterilized water according to the present embodiment, as in the first embodiment, first, Er: YAG laser irradiation and scaling exist in the deep periodontal pocket The biofilm to be removed is removed in advance, and then, for example, an irrigation chip is attached to an ultrasonic scaler, the tip of the irrigation chip is inserted into the periodontal pocket, and the sterilizing water according to the present embodiment is injected. Here, sterilizing water can be injected while removing the biofilm with an ultrasonic scaler.

In this way, when the sterilizing water according to this embodiment reaches the depth of the periodontal pocket while gradually sterilizing the sterilizing power due to oxidation of organic matter and other bacteria in the periodontal pocket. With this, it is possible to hold an acid scent that can sterilize periodontal disease bacteria and to kill periodontal disease bacteria. Of course, tooth decalcification can also be prevented beforehand.

[0180] Power! According to the sterilizing water according to this embodiment, since the concentration of hypochlorous acid (HCLO) is adjusted to 300 to 600 ppm, periodontal disease bacteria that inhabit deep in the periodontal pocket can be detected for several seconds. It can be completely sterilized within a moment (at a concentration of around 400-600ppm), and it is said that it cannot be killed. Thus, the sterilizing water according to the present embodiment capable of instant sterilization is epoch-making as in the first embodiment.

Next, FIG. 39 shows a generating apparatus for generating sterilizing water according to this embodiment.

[0182] As can be seen in the figure, the sterilizing water generator 21 according to the present embodiment includes a stock solution tank 3 that stores a stock solution 22, a stroke pump 4 that is connected in communication with the stock solution tank, and the stroke pump. The electrolytic tank 5 is connected in communication, the discharge pipe 6 is connected in communication with the electrolytic tank, and the dilution water tank 8 is stored with the dilution water 27, and the tip of the discharge pipe 6 is stored in the dilution water tank 8. The installation position of the dilution water tank 8 is relatively positioned with respect to the tip position of the discharge pipe 6 so as to be equal to or lower than the water level of the diluted water 27 that has been prepared.

[0183] Stock solution 22 is made by adding only sodium chloride (NaCL) to the water obtained by passing tap water through the reverse osmosis membrane, and adding acids such as hydrochloric acid and acetic acid!ヽヽ.

[0184] As the electrolytic cell 5, for example, an electrolytic cell used in an electrolysis neutral water generator sold by Sakai Engineering Co., Ltd. under the trade name "Epiosuko" can be used.

[0185] As dilution water 27, well water, tap water, pure water or any other water can be used, and the pH is appropriately selected so that the pH of the sterilized water to be generated is in the above-mentioned range.

[0186] The generation device 21 according to the present embodiment further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 30 in which the primary generation water is diluted with the dilution water 27 in the dilution water tank 8. The deaeration module is adapted to remove dissolved oxygen from the secondary product water 30 by depressurization by the vacuum pump 12, and to remove the dissolved oxygen from the secondary product water 30. A tertiary production water tank 14 for storing water as sterilizing water 33 is provided.

[0187] It should be noted that the tubes used in the generating device 21 or the electromagnetic valve provided as needed are likely to be deteriorated by the acid concentration of high-concentration hypochlorous acid (HCLO), and are therefore formed of fluorine. Is desirable.

[0188] In order to generate the sterilized water 33 using the sterilized water generator 21 according to the present embodiment, first, water is passed through a reverse osmosis membrane, and only sodium chloride sodium is added to the passing water. Prepare stock solution 22. [0189] Water purifiers equipped with reverse osmosis membranes have V and some manufacturer powers on the market, so these powers may be selected and adopted as appropriate.

[0190] The water may have any properties, but in order to reduce the burden on the reverse osmosis membrane and the water purifier using it, or to reduce the amount of waste water to some extent, Drowned water is desirable, and it is desirable to use water with a pH close to neutral in the sense that it produces sterilized water more safely. For example, ground water, tap water, or commercially available mineral water (commercial water) can be used.

[0191] If such water is passed through the reverse osmosis membrane, the pH of the passing water is approximately 5-6.

[0192] Even if various substances including minerals are contained in water, ions that contribute to pH are almost completely removed by the reverse osmosis membrane, and only dissolved carbon dioxide is present. Coupled with diacid carbon that passes through and dissolves from the atmosphere,

[0193] H CO → H + + HCO "

2 3 3

It is because it dissociates like this.

[0194] Next, sodium thorium is added to the water that has passed through the reverse osmosis membrane to make a stock solution 22, which is stored in the stock solution tank 3, and the stock solution 22 is sent to the electrolytic cell 5 by the stroke pump 4, The electrolytic cell 5 is operated under the specified operating conditions, and the stock solution 22 is electrolyzed.

[0195] Here, the amount of sodium chloride sodium added and the electrolysis conditions, which are the composition conditions of the stock solution, are determined by the concentration of hypochlorous acid (HCLO) after the primary water produced by electrolysis is diluted. Is set appropriately so that secondary product water of 300 to 600 ppm and pH of 6.3 to 6.7 is generated.

On the other hand, the dilution water tank 8 is filled with an amount of dilution water 27 corresponding to the dilution ratio.

[0197] Next, the primary generated water generated in the electrolytic cell 5 is injected into the diluted water 27 stored in advance in the diluted water tank 8 through the discharge pipe 6 connected to the electrolytic cell. To do.

[0198] Here, the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or less than the level of the dilution water 27 stored in the dilution water tank 8. is there.

[0199] Therefore, if the primary water is injected into the dilution water 27 via the discharge pipe 6, it is injected in a non-contact state with the air.

[0200] If this is done, the amount of sodium chloride added and the operating conditions of the electrolytic cell 5 should be the designed values. In contrast, even if chlorine gas is generated due to this, the chlorine gas changes its form to hypochlorous acid (HCLO) in diluted water 27 whose pH environment is close to neutral, and chlorine gas As a result, there is no longer any concern about evaporation.

[0201] Next, the secondary product water 30 is passed through the deaeration module 11 to produce tertiary product water from which dissolved gases, particularly dissolved oxygen, have been removed. Store in tank 14.

[0202] As described above, according to the method and apparatus 21 for producing sterilized water according to the present embodiment, the pH of the water that has passed through the reverse osmosis membrane depends on carbon dioxide in the atmosphere, and is approximately 5%. ~ 6.

[0203] Accordingly, it is possible to safely obtain a weakly acidic stock solution with a determined pH without the need to add an acid such as hydrochloric acid or acetic acid. Decomposition conditions and dilution conditions can be easily set.

[0204] And most of all, the dissolved substances contained in tap water and well water are removed in advance with a reverse osmosis membrane, and hydrochloric acid and acetic acid are not added at all, so it is possible to produce tasteless and odorless sterilized water. As a result, even if the concentration of hypochlorous acid (HCLO) is 500 ppm to 600 ppm, periodontal bacteria can be completely sterilized in a short time of several seconds per tooth without causing any discomfort to the patient. There is an epoch-making action effect.

[0205] Further, according to the sterilizing water generating method and generating device 21 according to the present embodiment, the dissolved gas is removed from the secondary generated water 30 to generate the tertiary generated water 33, which is used as the sterilizing water. Therefore, it is possible to prevent the foaming phenomenon in the periodontal pocket and prevent the periodontal disease bacteria from being sent into the body (intravascular).

[0206] In this embodiment, water is passed through a reverse osmosis membrane, and only saline and sodium chloride are added to the passing water to prepare a stock solution. Instead, pure water is used in the atmosphere for a predetermined period of time. The stock solution may be prepared by adding only sodium chloride to the standing water.

[0207] Even in a powerful configuration, there is no change in the pH of the stock solution determined by carbon dioxide in the atmosphere. Further, since the generation method and the generation apparatus are the same as those in the above-described embodiment, the description thereof is omitted here.

[0208] In the present embodiment, the degassing module 11 is used to remove dissolved gas in the secondary product water 30. However, if the concentration of the dissolved gas in the secondary product water 30 is low and there is no concern about the foaming phenomenon, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 30 is sterilized water.

FIG. 40 is a diagram showing the generation device 21a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generation device 21. .

[0209] Further, in this embodiment, the example in which the sterilizing water is generated so that the pH is 6.3 to 6.7 or 6.3 to 7 has been described, but the pH is 5.6 to 6.3. The same procedure can be followed for the production of sterilized water.

Further, in the present embodiment, the sterilizing water, its generating method and generating device for the purpose of sterilizing periodontal disease bacteria that live in the periodontal pockets have been described, but the sterilizing water according to the present invention is hypochlorous acid. (HCLO) concentration is 201-600ppm and pH is 6.3-7, so it is inherently strong bactericidal and pH is near neutral. Is unthinkable.

[0210] Therefore, the sterilizing water according to the present invention is not limited to use only for sterilization of periodontal disease bacteria living in the periodontal pocket, but can be applied to sterilization of any part of the human body and any part. It is. In addition, the application target is not limited to the human body.

[0211] In particular, if dissolved gas is removed, it is possible to prevent increased bleeding from the wound force due to the foaming phenomenon and prevent germs from entering the body. As water, it becomes a very useful means.

[0212] Needless to say, the generation method and the generation apparatus of the present embodiment can be applied as they are to the generation method and generation apparatus of the sterilizing water.

Example 4

[0213] (Experiment on generation of sterilizing water)

First, tap water was poured into a water purifier equipped with a reverse osmosis membrane, and then sodium chloride (NaCL) was added to the water that passed through the reverse osmosis membrane to prepare a stock solution.

[0214] Next, the stock solution was electrolyzed in an electrolytic cell to produce primary product water, and the primary product water was diluted with tap water. [0215] The electrolytic cell used was an electrolytic neutral water generation device sold by Sakai Engineering Co., Ltd. under the trade name "Epiosuko".

[0216] For dilution, the discharge pipe connected to the electrolytic cell is relatively positioned between the discharge pipe and the dilution water tank so that the tip of the discharge pipe is below the level of the dilution water stored in the dilution water tank. Positioned.

[0217] When electrolysis and dilution were carried out by the above process, 5 OOppm of sterilized water could be produced within the pH range of 6.3 to 6.7. Note that when measuring the concentration of hypochlorous acid (HC LO) in sterilized water, the instrument, test paper, or reagent capable of measuring concentrations exceeding 200 ppm was used. did.

[0218] As a control (standard reagent) for confirming the action and effect of 500 ppm sterilized water, 200 ppm sterilized water was also prepared in the same procedure.

Example 5

[0219] (Clinical trial using sterilized water)

While removing the biofilm with an ultrasonic scaler, a clinical trial was conducted in which sterilized water was injected into the periodontal pocket via an irrigation tip attached to the tip of the biofilm. The injection time was 10 seconds to avoid bacteremia.

[0220] First, treatment was performed by injecting sterilized water with a concentration of hypochlorous acid (HCLO) of 200 ppm and a pH of 6.3 to 6.7, and then the probe was placed in the periodontium without touching the saliva. Plaque and blood adhering to the root surface are collected at the bottom of the pocket, placed on a slide glass, suspended in physiological saline, covered with a cover glass, and this is a 3600 times high-resolution phase contrast microscope. Observed at.

[0221] Figures 41 to 47 show the results. As can be seen from these figures, scaling with 200 ppm hypochlorous acid water can confirm the bactericidal effect to some extent, but Campylobacter rectus and Treponema a denticola (Treponem a denticola ) Is still active, and it can be seen that complete sterilization has not been achieved. In addition, the results of this example also supported the test results of Example 1.

[0222] Therefore, sterilized water with a concentration of hypochlorous acid (HCLO) of 200 ppm cannot sufficiently kill the periodontal disease bacteria, and on the contrary, the periodontal disease bacteria are caused by periodontal transformation. It can be concluded that it can grow rapidly in the pocket.

[0223] Next, concentration 500 _PP m of hypochlorous acid (HClO), pH is 6. the same test was carried out using 3 to 6.7 sterilizing water.

[0224] The results are shown in Figs. As can be seen from these figures, in the irrigation using 500 ppm hypochlorous acid water, Campylobacter ^ ~~ · Rectus and Treponema denticola are completely killed. . Further, the result of this example also supported the test result of Example 3.

Claims

The scope of the claims

[1] In sterilized water containing hypochlorous acid (HCLO),

A sterilized water characterized in that the concentration of the hypochlorous acid (HCLO) is 201 to 600 ppm, the pH is 5.6 to 7, and the sterilization of periodontal disease bacteria living in the periodontal pocket is used.

[2] The sterilized water according to claim 1, wherein the sterilized water is 400 to 600 ppm instead of the 201 to 600 ppm.

[3] The sterilized water according to claim 1 or claim 2, wherein the water is replaced with 6.3 to 6.7 instead of 5.6 to 7.

[4] The sterilized water according to claim 1 or claim 2, wherein the 5.6 to 6.3 is used instead of the 5.6 to 7.

[5] In sterilized water containing hypochlorous acid (HCLO),

Bactericidal water characterized in that the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7.

[6] Bactericidal water intended for the sterilization of periodontal disease bacteria that live in periodontal pockets by diluting primary product water obtained by electrolyzing a stock solution of sodium chloride and acid added to water In which the concentration of hypochlorous acid contained in the sterilized water is S201 to 600 ppm, and the sodium chloride and the acid are added so that the pH is 5.6 to 7. After setting the stock solution composition conditions, electrolysis conditions and dilution conditions including the volume, preparing the stock solution according to the stock solution composition conditions, electrolyzing the stock solution according to the electrolysis conditions, The generated primary product water comprises a step of diluting according to the dilution conditions. In the dilution step, the primary product water is poured into the dilution water through a predetermined discharge pipe, and the injection pipe is used for injection. The tip position of is below the water level of the dilution water Method for generating sterile water, characterized in that the sea urchin.

[7] Pass water through the reverse osmosis membrane, add only sodium chloride to the passing water to make a stock solution, electrolyze the stock solution into primary product water, dilute the primary product water A method for producing sterilized water containing chlorous acid (HCLO), wherein the concentration of hypochlorous acid contained in the sterilized water is 201 to 600 ppm and the pH is 5.6 to 7. The stock solution composition conditions including the amount of calories added to the sodium chloride, electrolysis conditions, and dilution conditions are set, and after the stock solution is prepared according to the stock solution composition conditions, the stock solution is electrolyzed according to the electrolysis conditions, And then diluting the primary product water generated by electrolysis according to the dilution conditions. In the dilution step, the primary product water is injected into the dilution water through a predetermined discharge pipe. In addition, a method for producing sterilizing water is characterized in that, at the time of injection, the tip end position of the discharge pipe is set to be equal to or lower than the water level of the dilution water.

[8] Leave pure water in the atmosphere for a specified period of time, add only sodium chloride to the standing water to make a stock solution, electrolyze the stock solution into primary product water, and dilute the primary product water And producing sterilized water containing hypochlorous acid (H CLO), wherein the concentration of hypochlorous acid contained in the sterilized water is 201 to 600 ppm, and the pH is 5.6 to The stock solution composition conditions including the amount of sodium chloride added, the electrolysis conditions, and the dilution conditions were set so as to be 7, and after preparing the stock solution according to the stock solution composition conditions, the stock solution was prepared according to the electrolysis conditions. Electrolysis is performed, and then the primary product water generated by electrolysis is diluted in accordance with the dilution conditions. In the dilution step, the primary product water is diluted into diluted water through a predetermined discharge pipe. At the time of injection, the tip position of the discharge pipe is below the level of dilution water. Method for generating sterile water, characterized in that Unisuru.

[9] The pH of the stock solution is calculated using the solubility of carbon dioxide at the temperature at which the stock solution is produced and the concentration of carbon dioxide in the atmosphere, and V is used to calculate the stock solution composition conditions. The method for producing bactericidal water according to claim 7 or 8, wherein the electrolysis conditions and the dilution conditions are set.

[10] The method for producing sterilized water according to any one of [6] to [9], wherein the content is 400 to 600 ppm instead of the 201 to 600 ppm.

[11] The method for producing sterilized water according to any one of claims 6 to 9, wherein 6.3 to 6.7 is used instead of 5.6 to 7.

[12] The method for producing sterilized water according to any one of claims 6 to 9, wherein 5.6 to 6.3 is used instead of 5.6 to 7.

[13] An apparatus for electrolyzing the stock solution in the electrolytic cell to produce sterilized water containing hypochlorous acid (HCLO).

A stock solution tank for storing the stock solution, an electrolytic bath connected to the stock solution tank, a discharge pipe connected to the electrolytic bath, and a dilution water tank storing dilution water. Position the dilution water tank relative to the tip position of the discharge pipe so that the tip of the discharge pipe is below the level of the dilution water stored in the dilution water tank. A sterilizing water generator for generating sterilizing water for use in sterilization of periodontal disease bacteria that have been determined and inhabit the periodontal pocket.

[14] A sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria living in the periodontal pocket, and the water is passed through the reverse osmosis membrane to pass water. A stock solution tank for storing a stock solution to which only sodium is added, an electrolytic cell connected to the stock solution tank for electrolyzing the stock solution to generate primary product water, and a discharge pipe connected to the electrolytic cell Diluted water that is diluted into the sterilized water by diluting the primary product water discharged through the tank is stored in advance, and the discharge pipe is relatively positioned so that the tip of the discharge pipe is below the level of the diluted water. An amount of sodium chloride added so that the concentration of the hypochlorous acid (HCLO) in the sterilized water is 201 to 600 ppm and the pH is 5.6 to 7. The operating condition of the electrolytic cell is determined or the dilution condition is determined Generating device of sterile water to be.

[15] A sterilizing water generating device for generating sterilizing water for the sterilization of periodontal disease bacteria living in the periodontal pocket, and the pure water is left in the atmosphere for a predetermined period. A stock solution tank for storing a stock solution to which only sodium chloride is added, an electrolytic cell connected to the stock solution tank and electrolyzing the stock solution to generate primary product water, and a connected to the electrolytic cell Diluted water that is diluted as primary sterilized water discharged through the discharged discharge pipe to be sterilized water is stored in advance, and the discharge pipe has a leading end that is below the level of the diluted water. A diluting water tank that is relatively positioned, and the chloride is adjusted so that the concentration of the hypochlorous acid (HCLO) in the sterilized water is 201 to 600 ppm and the pH is 5.6 to 7. Determine the amount of sodium added, the operating conditions of the electrolytic cell, or the dilution conditions. Generator of sterile water and said.

[16] The apparatus for producing sterilized water according to any one of the above-mentioned items of 201 to 600 ppm [instead of! / In claim 13 to claim 15].

[17] The apparatus for producing sterilized water according to any one of claims 13 to 15, wherein 6.3 to 6.7 is used instead of 5.6 to 7.

[18] The apparatus for producing sterilized water according to any one of claims 13 to 15, wherein 5.6 to 6.3 is used instead of 5.6 to 7.