WO2011058764A1 - Gargle preparation, and process and apparatus for production of same - Google Patents

Gargle preparation, and process and apparatus for production of same Download PDF

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WO2011058764A1
WO2011058764A1 PCT/JP2010/006682 JP2010006682W WO2011058764A1 WO 2011058764 A1 WO2011058764 A1 WO 2011058764A1 JP 2010006682 W JP2010006682 W JP 2010006682W WO 2011058764 A1 WO2011058764 A1 WO 2011058764A1
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gargle
water
ppm
carbon dioxide
stock solution
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PCT/JP2010/006682
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French (fr)
Japanese (ja)
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宗則 野口
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パーフェクトペリオ株式会社
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • the present invention relates to a gargle, a method for producing the same, and a device for producing the same, mainly for the sterilization of viruses that cause infections in human bodies due to respiratory tract infection.
  • Infectious diseases caused by viruses begin with the adsorption of viruses to human cells, which part of the body becomes the site of entry of the virus varies from virus to virus. , Contact infection and wound infection.
  • viruses that have caused respiratory tract infection as an entry gate include influenza virus, coronavirus, which is a pathogen of SARS, measles virus, rubella virus, and the like.
  • Poppylon iodine is widely known as a mouthwash that can remove viruses, that is, an gargle, and iodine in the ingredients often shows a certain effectiveness against pathogenic microorganisms such as viruses and fungi and bacteria.
  • Patent Document 1 Known (Patent Document 1).
  • Non-Patent Document 1 New influenza (A / H1N1), which is showing a worldwide epidemic at the time of filing, has a larger scale of infection than seasonal influenza, and therefore, safer and more reliable infection prevention measures have become more urgent than before.
  • the present invention has been made in consideration of the above-described circumstances, and provides a gargle capable of removing viruses in the vicinity of the pharynx without damaging epithelial cells of the pharynx, a method for producing the same, and a device for producing the same. With the goal.
  • the gargle according to the present invention has an effective chlorine concentration of 50 to 300 ppm, a pH of 6.3 to 8, contains hypochlorous acid and sodium bicarbonate, and is present in the pharynx. It is intended for virus removal.
  • the gargle according to the present invention has an effective chlorine concentration of 50 to 250 ppm.
  • the gargle according to the present invention has the effective chlorine concentration of 50 to 200 ppm.
  • the gargle according to the present invention has a pH of 7-8 instead of 6.3-8.
  • the method for producing a gargle according to the present invention is used for removing viruses present in the pharynx, and an aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution.
  • a method for producing a gargle that produces hypochlorous acid and sodium hydrogen carbonate having a predetermined concentration by electrolyzing so as to have an effective chlorine concentration of 50 to 300 ppm and a pH of 6.3 to 8.
  • the stock solution By passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, blowing carbon dioxide or adding dry ice simultaneously with or before and after the sodium chloride addition step, By adding sodium chloride to pure water or distilled water, blowing carbon dioxide or adding dry ice simultaneously with or before and after the sodium chloride addition step, By passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, and making the partial pressure of carbon dioxide in contact with the passing water higher than the partial pressure in the atmosphere, or While adding sodium chloride to pure water or distilled water, by making the carbon dioxide partial pressure in contact with the pure water or the distilled water higher than the partial pressure in the atmosphere, Each is made.
  • the method for producing a gargle according to the present invention is such that the effective chlorine concentration is 50 to 250 ppm.
  • the method for producing a gargle according to the present invention is such that the effective chlorine concentration is 50 to 200 ppm.
  • the method for producing a gargle according to the present invention is such that the pH is 7 to 8 instead of 6.3 to 8.
  • the gargle production apparatus is an apparatus for producing a gargle for the purpose of removing viruses present in the pharynx as described in claim 9, to which sodium chloride and carbon dioxide are added.
  • the electrolytic bath has an effective chlorine concentration of 50 to 300 ppm by electrolyzing the stock solution,
  • the pH is 6.3 to 8, and a gargle containing hypochlorous acid and sodium hydrogen carbonate is produced.
  • the gargle producing apparatus has an effective chlorine concentration of 50 to 250 ppm.
  • the gargle producing apparatus has the effective chlorine concentration of 50 to 200 ppm.
  • the gargle producing apparatus according to the present invention has a pH of 7 to 8 instead of 6.3 to 8.
  • Viruses die outside of living cells in a very short time unless they are in a special environment, but once they have entered the living cells, they escape from humoral immunity and proliferate parasitically in the cells.
  • Mouthwashes based on cineol and thymol and gargles based on poppyon iodine have been verified to have certain bactericidal properties against such viruses, but on the other hand, There is also concern about the toxicity to epithelial cells.
  • the gargle according to the present invention has sodium bicarbonate (NaHCO 3 ) functioning as a buffer, and the pH of the entire gargle is maintained in the range of 6.3 to 8, thus ensuring safety for the human body.
  • NaHCO 3 sodium bicarbonate
  • the virus present in the pharynx can be killed by the bactericidal power of hypochlorous acid (HClO) present at a high level.
  • the effective chlorine concentration is 50 ppm or more and the abundance ratio of hypochlorous acid (HClO) is set to a pH range, it enters the epithelial cells of the pharynx and exists in the cytoplasm The virus can be reliably killed with hypochlorous acid.
  • the effective chlorine concentration is set to 300 ppm or less, preferably 250 ppm or less, more preferably 200 ppm or less. It is possible to minimize the damage to the cells and to surely avoid the death of the epithelial cells.
  • the above-mentioned hypochlorous acid shows high bactericidal activity against bacteria composed of prokaryotic cells not having a nuclear membrane, and can surely kill bacteria living in the pharynx.
  • hypochlorous acid selectively kills only viruses that invade the cytoplasm that makes up the pharyngeal epithelial cells and bacteria that inhabit the pharynx, while minimizing damage to the pharyngeal epithelial cells. It becomes possible.
  • Hypochlorous acid has a property of easily binding to an amino group, but since the virus is covered with a protein called capsid, the virus can be easily destroyed.
  • sodium hydrogencarbonate (NaHCO 3 ) is a hypochlorous acid to virus by destroying the biofilm in a situation where the biofilm inhibits hypochlorous acid (HClO) from contacting the virus. It also serves to allow acid (HClO) contact.
  • the target virus in the present invention is an invasion site serving as an entrance of infection to the human body, that is, the intrusion gate is the upper respiratory tract (range from the oral cavity and nasal cavity to the larynx through the pharynx), specifically, Influenza virus, measles virus, rubella virus, varicella virus, mumps virus which is a pathogen of epidemic parotitis, and coronavirus which is a pathogen of SARS.
  • the intrusion gate is the upper respiratory tract (range from the oral cavity and nasal cavity to the larynx through the pharynx), specifically, Influenza virus, measles virus, rubella virus, varicella virus, mumps virus which is a pathogen of epidemic parotitis, and coronavirus which is a pathogen of SARS.
  • forced dissolution of carbon dioxide means that the solubility of carbon dioxide is higher than the concentration at which it can be dissolved naturally (the solubility under the partial pressure of carbon dioxide present in the atmosphere).
  • the stock solution may be prepared by any of the following methods (a) to (d). In any of these methods, hydrochloric acid, acetic acid or other carbonic acid is used. Do not add any acid except. Therefore, the main solution composition condition is the amount of sodium chloride added.
  • the water that is a component of the stock solution in (a) and (c) can use well water, tap water, etc., and it is not necessary to use pure water.
  • the reason why the pH is desirably 7 or more is that it is possible to prevent acidification in the oral cavity caused by lactic acid produced by cariogenic pathogenic bacteria.
  • the effective chlorine concentration is 50 to 300 ppm is that if it is less than 50 ppm, it is difficult to kill the virus because of its low bactericidal activity. If it exceeds 300 pm, the cell nucleus is surrounded by the nuclear membrane. Nonetheless, there are concerns about injury to epithelial cells in the human body.
  • the reason why the effective chlorine concentration is desirably 50 to 250 ppm is that the concern about the damage to the epithelial cells can be further reduced, and more desirably 50 to 200 ppm is the possibility of the damage to the epithelial cells. This is because it can be made substantially zero.
  • the gargle according to this embodiment contains hypochlorous acid (HClO) and sodium hydrogen carbonate (NaHCO 3 ), and the effective chlorine concentration is 50 to 300 ppm, preferably 50 to 250 ppm, more preferably 50 to 200 ppm.
  • the pH is 6.3 or more and 8 or less, preferably 7 or more and 8 or less, and the purpose is to remove viruses present in the pharynx.
  • FIG. 1 shows an apparatus for producing a gargle according to this embodiment.
  • the gargle generating apparatus 51 includes a stock solution tank 3 that stores a stock solution 52, a stroke pump 4 that is connected to the stock solution tank, and a communication pump that is connected to the stroke pump.
  • the installation position of the dilution water tank 8 is relatively positioned with respect to the tip position of the discharge pipe 6 so as to be equal to or lower than the water level of the water 57.
  • the stock solution 52 is prepared by any of the methods described below, but no acid other than hydrochloric acid, acetic acid or other carbonic acid is added in any of the methods.
  • the dilution water 57 may be well water, tap water, pure water or any other water, but the pH is appropriately selected so that the pH of the gargle to be generated is in the above-mentioned range.
  • the generation apparatus 51 further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 60 obtained by diluting the primary generation water with the dilution water 57 in the dilution water tank 8.
  • the deaeration module is adapted to remove dissolved oxygen from the secondary product water 60 by decompression by the vacuum pump 12, and contains the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 60.
  • the tubes used in the generation device 51 or the electromagnetic valve provided as necessary may be deteriorated by oxidation with a high concentration of hypochlorous acid, so that it is desirable to form with fluorine.
  • the effective chlorine concentration of the tertiary product water is 50 to 300 ppm, desirably 50 to 250 ppm, more desirably 50 to 200 ppm.
  • the composition conditions of the stock solution 52 mainly the amount of sodium chloride added
  • the operating conditions during the electrolysis eg voltage value and current value
  • dilution so that the pH is 6.3 to 8, preferably 7 to 8.
  • the conditions are determined, and the blended stock solution 52 is stored in the stock solution tank 3.
  • Sodium chloride is added, for example, 2 to 5% by mass.
  • the method for temporarily increasing the solubility of carbon dioxide can be further classified into either a method by blowing carbon dioxide or a method by adding dry ice.
  • temporary means that the partial pressure of carbon dioxide in contact with the solvent is equal to the partial pressure of carbon dioxide present in the atmosphere.
  • carbon dioxide is mixed at atmospheric pressure, Even when forced press-fitting is performed, the solubility of carbon dioxide decreases with time due to pressure equilibrium with the partial pressure of carbon dioxide contained in the air. In this case, it is necessary to perform electrolytic treatment promptly before the solubility of carbon dioxide decreases.
  • the water is passed through a reverse osmosis membrane, pure water or distilled water is used as a solvent, and the solvent is sealed in an airtight tank.
  • a method in which carbon dioxide is injected or carbon dioxide gas is blown into a solvent in an airtight tank or dry ice is added to the solvent can be employed.
  • the forced dissolution of carbon dioxide is made by selecting one of the following methods.
  • the water that passes through the reverse osmosis membrane may be of any property, but it is purified to some extent in the sense of reducing the burden on the reverse osmosis membrane and the water purifier using it, or reducing the amount of waste water as much as possible.
  • Water is desirable.
  • ground water, tap water, or commercially available mineral water (commercial water) can be used.
  • tap water is used as the water that passes through the reverse osmosis membrane.
  • the stock solution 52 is then weighed in an amount corresponding to one batch of gargle and stored in the stock solution tank 3, and diluted water 57 of an amount corresponding to one batch of gargle is also added.
  • the dilution water tank 8 Stored in the dilution water tank 8.
  • the amount of the dilution water 57 corresponding to one batch of the gargle may be appropriately determined according to the dilution rate and the pH of the dilution water.
  • the stock solution 52 is sent to the electrolytic cell 5 by the stroke pump 4, and the electrolytic cell 5 is operated under predetermined operating conditions to electrolyze the stock solution 52.
  • the primary generated water generated in the electrolytic cell 5 is injected into the diluted water 57 previously stored in the diluted water tank 8 through the discharge pipe 6 connected to the electrolytic cell.
  • the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 57 stored in the dilution water tank 8.
  • the primary product water is injected into the dilution water 57 through the discharge pipe 6 without coming into contact with air (outside air).
  • the primary product water is injected into the diluting water 57 weighed in advance in a so-called batch system, the primary product water is diluted with the dilution water unlike conventional mixing in the pipe. 57 is mixed homogeneously.
  • the secondary generated water 60 is passed through the degassing module 11 to generate tertiary generated water from which dissolved gas, particularly dissolved oxygen is removed, and this is stored in the tertiary generated water tank 14 as a gargle 33. To do.
  • the gargle may be contained in the oral cavity for several seconds to several tens of seconds.
  • the pH of the entire gargle is maintained in the range of 6.3 to 8 in which the abundance ratio of hypochlorous acid (HClO) is kept high by sodium hydrogen carbonate (NaHCO 3 ), and is contained in the gargle 63. While the virus present in the pharynx is rapidly removed by the bactericidal power of hypochlorous acid (HClO), the safety to the human body is ensured by the buffer action by sodium hydrogen carbonate (NaHCO 3 ).
  • an aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution, and the stock solution has an effective chlorine concentration of 50 to 50. 300 ppm, preferably 50-250 ppm, more preferably 50-200 ppm, and the pH is 6.3-8, preferably 7-8. Electrolysis is performed so that the virus present in the pharynx can be sterilized. It becomes possible to produce hypochlorous acid having a concentration and sodium hydrogen carbonate (NaHCO 3 ) capable of maintaining a pH environment where the abundance ratio of hypochlorous acid is high.
  • NaHCO 3 sodium hydrogen carbonate
  • the production method and the production apparatus 51 of the gargle 63 since carbon dioxide is forcibly dissolved, a high concentration sodium hydrogen carbonate is produced and resistance to pH fluctuation ( It is possible to produce a tasteless and odorless gargle because there is no need to add acid such as hydrochloric acid or acetic acid, and even if the effective chlorine concentration is 300 ppm, there is no problem. There is a remarkable effect that the virus in the pharynx can be removed without giving pleasure and with a short period of rinsing for several seconds to several tens of seconds.
  • the effective chlorine concentration is 50 ppm or more and the pH ratio is high in the ratio of hypochlorous acid (HClO), bacteria that are prokaryotes having no nuclear membrane
  • the effective chlorine concentration is 300 ppm or less, preferably 250 ppm or less, more preferably 200 ppm or less. The protective action of the cell nucleus by the nuclear membrane is not impaired, and thus the damage to the epithelial cells of the human body can be minimized.
  • the effective chlorine concentration is 50 to 300 ppm, preferably 50 to 250 ppm, more preferably 50 to 200 ppm, so that the epithelial cells of the pharynx are not damaged, Only viruses that have entered bacteria and cells can be selectively attacked and killed.
  • hypochlorous acid binds to an amino group present in the capsid, so that the virus can be easily destroyed.
  • the dissolved gas in the secondary product water 60 is removed using the degassing module 11, but there is a concern that a foaming phenomenon may occur because the concentration of the dissolved gas in the secondary product water 60 is low. If not, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 60 becomes a gargle.
  • FIG. 2 is a diagram showing a generating device 51a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generating device 21.
  • the stock solution 52 and the dilution water 57 corresponding to one batch of the gargle are weighed and stored in the stock solution tank 3 and the dilution water tank 8 in advance. If the stock solution 52 in an amount larger than one batch of the gargle, for example, an amount corresponding to several batches is stored in the stock solution tank 3 in advance, the amount of the stock solution 52 corresponding to one batch of the gargle is determined. What is necessary is just to provide the water level measurement means for measuring each time. Such water level measuring means can be appropriately configured by, for example, an ultrasonic sensor, an electrode type sensor or the like.
  • the stock solution is electrolyzed and then diluted to produce a gargle, but instead, the stock solution is diluted and then the diluted water is electrolyzed.
  • a gargle may be obtained.
  • the stock solution is electrolyzed and then diluted to produce a gargle (post-dilution).
  • the stock solution is diluted, and then the diluted water is added.
  • the gargle may be obtained by electrolysis (pre-dilution).
  • the dilution water tank 8 is omitted, and instead, a diluted stock solution tank for storing the diluted stock solution is separately provided between the stock solution tank 3 and the electrolytic cell 5. That's fine.
  • the diluted stock solution was electrolyzed in an electrolytic cell to obtain a gargle.
  • the electrolytic cell used was an electrolytic neutral water generating device manufactured by Sakai Engineering Co., Ltd. and sold under the trade name “Perfect Perio” by Noguchi Dental Institute.
  • Test solution A By adding 5% (w / v) of dry ice to distilled water at atmospheric pressure and at room temperature, carbon dioxide constituting the dry ice is dissolved in the distilled water (saturated carbonated water). 0.6% (w / v) was dissolved.
  • Test solution B Saturated carbonated water, which is an intermediate product of test solution A, was diluted 5-fold with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
  • Test solution C Saturated carbonated water, which is an intermediate product of the test solution A, was diluted 10 times with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
  • Test solution D By exposing distilled water to the atmosphere under atmospheric pressure and room temperature, carbon dioxide in the air was dissolved in the distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
  • Test method 4 L of the above stock solution was put into a non-membrane type electrolytic cell, and electrolysis was performed with a direct current of 2.8 A.
  • Test Solution A to Test Solution C using saturated carbonated water have a pH range in which hypochlorous acid and sodium bicarbonate can be present in sufficient concentrations, that is, 6 to 8.
  • the pH of the test solution D in which carbon dioxide in the air was naturally dissolved was 9.2. Therefore, it seems that it is difficult to produce both hypochlorous acid and sodium hydrogen carbonate at a sufficient concentration by the method of spontaneously dissolving carbon dioxide in the air.

Abstract

Disclosed is a gargle preparation which can remove viruses that are present adjacent to the pharynx without damaging mucosal cells in the pharynx. Specifically disclosed is a gargle preparation (63) which comprises hypochlorous acid (HClO) and sodium hydrogen carbonate (NaHCO3), has an effective chlorine concentration of 50 to 300 ppm, desirably 50 to 250 ppm, more desirably 50 to 200 ppm, has a pH value of 6.3 to 8 inclusive, desirably 7 to 8 inclusive. The pH value of the gargle preparation (63) can be kept as a whole within a range from 6.3 to 8 in which hypochlorous acid (HClO) can be present at a high concentration, by the action of sodium hydrogen carbonate (NaHCO3). Therefore, when the gargle preparation (63) is put in the oral cavity and the throat is gargled with the gargle preparation (63) for a few seconds to several tens of seconds, viruses present in the pharynx can be removed rapidly by the germicidal action of hypochlorous acid (HClO) contained in the gargle preparation (63) and the safety of the gargle preparation for the human body can be ensured by the buffering action of sodium hydrogen carbonate (NaHCO3).

Description

含嗽剤及びその生成方法並びにその生成装置Gargle, production method thereof, and production apparatus thereof
　本発明は、主として経気道感染によって人体に感染症を引き起こすウィルスの殺菌を用途とした含嗽剤及びその生成方法並びにその生成装置に関する。 The present invention relates to a gargle, a method for producing the same, and a device for producing the same, mainly for the sterilization of viruses that cause infections in human bodies due to respiratory tract infection.
　ウィルスによる感染症は、人体細胞へのウィルスの吸着に始まるが、生体のどの部位がウィルスの侵入部位となるかはウィルスごとに異なっており、かかる侵入部位の違いによって、経口感染、経気道感染、接触感染、創傷感染といった分類がなされている。 Infectious diseases caused by viruses begin with the adsorption of viruses to human cells, which part of the body becomes the site of entry of the virus varies from virus to virus. , Contact infection and wound infection.
　これらのうち、経気道感染を侵入門戸としたウィルスとしては、インフルエンザウィルスやＳＡＲＳの病原体であるコロナウィルスをはじめ、麻疹ウィルス、風疹ウィルスなどが知られている。 Among these, viruses that have caused respiratory tract infection as an entry gate include influenza virus, coronavirus, which is a pathogen of SARS, measles virus, rubella virus, and the like.
　経気道感染は、咳やくしゃみに伴う飛沫に含まれているウィルスが咽頭の上皮細胞に存在するレセプターに吸着し、該ウィルスが上皮細胞に取り込まれ、あるいは侵入することで感染が始まるものであるため、水やうがい薬でうがいすることによって、咽頭上皮細胞へのウィルス付着、ひいてはウィルスによる感染を抑えることができる。
特開２０００－１６９３７８ 「みずうがいで風邪発症が４割減少」（２００５年１２月６日）、京都大学保健管理センター、[平成２１年１１月１２日検索]、インターネット＜URL : http://www.kyoto-u.ac.jp/health/006.htm＞ In respiratory tract infection, the virus contained in the droplets associated with coughing and sneezing is adsorbed to a receptor present in the epithelial cells of the pharynx, and the infection starts when the virus is taken into or invades the epithelial cells. Therefore, by gargleing with water or a mouthwash, virus adhesion to the pharyngeal epithelial cells, and consequently infection by the virus, can be suppressed.
JP 2000-169378 "Mizuigai reduces cold onset by 40%" (December 6, 2005), Kyoto University Health Management Center, [Search November 12, 2009], Internet <URL: http: //www.kyoto-u .ac.jp / health / 006.htm>
　ウィルスを除去可能なうがい薬、すなわち含嗽剤としてはポピヨンヨードが広く知られており、成分中のヨウ素がウィルスをはじめとした真菌や細菌等の病原微生物に対し、一定の有効性を示すことはよく知られている（特許文献１）。 Poppylon iodine is widely known as a mouthwash that can remove viruses, that is, an gargle, and iodine in the ingredients often shows a certain effectiveness against pathogenic microorganisms such as viruses and fungi and bacteria. Known (Patent Document 1).
　しかしながら、その殺菌性ゆえ、咽頭の上皮細胞も傷めてしまい、結果としてウィルスの侵入を十分に阻止できないのではないかという懸念が最近になって指摘され始めているとともに（非特許文献１）、本出願時に世界的流行を見せている新型インフルエンザ（Ａ／Ｈ１Ｎ１）は、季節型インフルエンザよりもその感染拡大の規模が大きいため、従来にも増して安全確実な感染予防策が急務となっていた。 However, due to its bactericidal properties, epithelial cells of the pharynx are also damaged, and as a result, there is a recent concern that the invasion of viruses cannot be sufficiently prevented (Non-Patent Document 1). New influenza (A / H1N1), which is showing a worldwide epidemic at the time of filing, has a larger scale of infection than seasonal influenza, and therefore, safer and more reliable infection prevention measures have become more urgent than before.
　本発明は、上述した事情を考慮してなされたもので、咽頭の上皮細胞を傷めることなくかつ咽頭近傍のウィルスを除去することが可能な含嗽剤及びその生成方法並びにその生成装置を提供することを目的とする。 The present invention has been made in consideration of the above-described circumstances, and provides a gargle capable of removing viruses in the vicinity of the pharynx without damaging epithelial cells of the pharynx, a method for producing the same, and a device for producing the same. With the goal.
　本発明に係る含嗽剤は請求項１に記載したように、有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８であって、次亜塩素酸及び炭酸水素ナトリウムを含み、咽頭に存在するウィルスの除去を用途としたものである。 As described in claim 1, the gargle according to the present invention has an effective chlorine concentration of 50 to 300 ppm, a pH of 6.3 to 8, contains hypochlorous acid and sodium bicarbonate, and is present in the pharynx. It is intended for virus removal.
　また、本発明に係る含嗽剤は、前記有効塩素濃度を５０～２５０ｐｐｍとしたものである。 In addition, the gargle according to the present invention has an effective chlorine concentration of 50 to 250 ppm.
　また、本発明に係る含嗽剤は、前記有効塩素濃度を５０～２００ｐｐｍとしたものである。 The gargle according to the present invention has the effective chlorine concentration of 50 to 200 ppm.
　また、本発明に係る含嗽剤は、ｐＨを、前記６．３～８に代えて、７～８としたものである。 In addition, the gargle according to the present invention has a pH of 7-8 instead of 6.3-8.
　また、本発明に係る含嗽剤の生成方法は請求項５に記載したように、咽頭に存在するウィルスの除去を用途とするとともに、塩化ナトリウム及び二酸化炭素が添加された水溶液を原液とし、該原液を、有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８となるように電気分解することにより、所定濃度の次亜塩素酸及び炭酸水素ナトリウムを生成させる含嗽剤の生成方法であって、前記原液を、
　水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加し、該塩化ナトリウムの添加工程と同時に又はその前後に炭酸ガスを吹き込み又はドライアイスを添加することによって、
　純水又は蒸留水に塩化ナトリウムを添加し、該塩化ナトリウムの添加工程と同時に又はその前後に炭酸ガスを吹き込み又はドライアイスを添加することによって、
　水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加するとともに、前記通過水に接する二酸化炭素分圧を大気中の分圧よりも高くすることによって、又は、
　純水又は蒸留水に塩化ナトリウムを添加するとともに、前記純水又は前記蒸留水に接する二酸化炭素分圧を大気中の分圧よりも高くすることによって、
それぞれ作製するものである。 In addition, as described in claim 5, the method for producing a gargle according to the present invention is used for removing viruses present in the pharynx, and an aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution. Is a method for producing a gargle that produces hypochlorous acid and sodium hydrogen carbonate having a predetermined concentration by electrolyzing so as to have an effective chlorine concentration of 50 to 300 ppm and a pH of 6.3 to 8. The stock solution,
By passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, blowing carbon dioxide or adding dry ice simultaneously with or before and after the sodium chloride addition step,
By adding sodium chloride to pure water or distilled water, blowing carbon dioxide or adding dry ice simultaneously with or before and after the sodium chloride addition step,
By passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, and making the partial pressure of carbon dioxide in contact with the passing water higher than the partial pressure in the atmosphere, or
While adding sodium chloride to pure water or distilled water, by making the carbon dioxide partial pressure in contact with the pure water or the distilled water higher than the partial pressure in the atmosphere,
Each is made.
　また、本発明に係る含嗽剤の生成方法は、前記有効塩素濃度を５０～２５０ｐｐｍとしたものである。 In addition, the method for producing a gargle according to the present invention is such that the effective chlorine concentration is 50 to 250 ppm.
　また、本発明に係る含嗽剤の生成方法は、前記有効塩素濃度を５０～２００ｐｐｍとしたものである。 Further, the method for producing a gargle according to the present invention is such that the effective chlorine concentration is 50 to 200 ppm.
　また、本発明に係る含嗽剤の生成方法は、ｐＨを前記６．３～８に代えて、７～８としたものである。 In addition, the method for producing a gargle according to the present invention is such that the pH is 7 to 8 instead of 6.3 to 8.
　また、本発明に係る含嗽剤の生成装置は請求項９に記載したように、咽頭に存在するウィルスの除去を用途とした含嗽剤を生成する装置であって、塩化ナトリウム及び二酸化炭素が添加された原液を貯留する原液タンクと、該原液タンクに連通接続され前記原液を電気分解する電解槽とを備え、該電解槽は、前記原液を電気分解することによって、有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８であって、次亜塩素酸及び炭酸水素ナトリウムを含む含嗽剤を生成するようになっているものである。 The gargle production apparatus according to the present invention is an apparatus for producing a gargle for the purpose of removing viruses present in the pharynx as described in claim 9, to which sodium chloride and carbon dioxide are added. A stock solution tank for storing the stock solution, and an electrolytic tank connected to the stock solution tank for electrolyzing the stock solution. The electrolytic bath has an effective chlorine concentration of 50 to 300 ppm by electrolyzing the stock solution, The pH is 6.3 to 8, and a gargle containing hypochlorous acid and sodium hydrogen carbonate is produced.
　また、本発明に係る含嗽剤の生成装置は、前記有効塩素濃度を５０～２５０ｐｐｍとしたものである。 Further, the gargle producing apparatus according to the present invention has an effective chlorine concentration of 50 to 250 ppm.
　また、本発明に係る含嗽剤の生成装置は、前記有効塩素濃度を５０～２００ｐｐｍとしたものである。 Further, the gargle producing apparatus according to the present invention has the effective chlorine concentration of 50 to 200 ppm.
　また、本発明に係る含嗽剤の生成装置は、ｐＨを前記６．３～８に代えて、７～８としたものである。 In addition, the gargle producing apparatus according to the present invention has a pH of 7 to 8 instead of 6.3 to 8.
　ウィルスは、生体細胞の外では、特殊な環境でない限り、ごく短時間で死滅するが、いったん生体細胞内に侵入した後は、体液性免疫から逃れながら、該細胞内に寄生して増殖する。 Viruses die outside of living cells in a very short time unless they are in a special environment, but once they have entered the living cells, they escape from humoral immunity and proliferate parasitically in the cells.
　シネオールやチモールを主成分とする洗口液やポピヨンヨードを主成分とするうがい薬は、このようなウィルスに対しても一定の殺菌性があることが検証されているが、その反面、人体内の上皮細胞に対して傷害性があることも懸念されている。 Mouthwashes based on cineol and thymol and gargles based on poppyon iodine have been verified to have certain bactericidal properties against such viruses, but on the other hand, There is also concern about the toxicity to epithelial cells.
　それに対し、本発明に係る含嗽剤は、炭酸水素ナトリウム（ＮａＨＣＯ3）が緩衝剤として機能し、含嗽剤全体のｐＨが６．３～８の範囲に維持されるので、人体に対する安全を確保しつつ、高水準で存在する次亜塩素酸（ＨＣｌＯ）の殺菌力で咽頭に存在するウィルスを死滅させることができる。 On the other hand, the gargle according to the present invention has sodium bicarbonate (NaHCO 3 ) functioning as a buffer, and the pH of the entire gargle is maintained in the range of 6.3 to 8, thus ensuring safety for the human body. However, the virus present in the pharynx can be killed by the bactericidal power of hypochlorous acid (HClO) present at a high level.
　すなわち、本発明に係る含嗽剤によれば、有効塩素濃度が５０ｐｐｍ以上でかつ次亜塩素酸（ＨＣｌＯ）の存在比率が高いｐＨ範囲としたので、咽頭の上皮細胞に侵入しその細胞質に存在するウィルスを次亜塩素酸で確実に死滅させることができる。
　一方、咽頭の上皮細胞は、真核細胞であってＤＮＡが核膜で守られているため、有効塩素濃度を３００ｐｐｍ以下、望ましくは２５０ｐｐｍ以下、さらに望ましくは２００ｐｐｍ以下とすることにより、咽頭の上皮細胞に対する傷害性を最小限にとどめるとともに、該上皮細胞の死滅を確実に回避することが可能となる。
　また、上述の次亜塩素酸は、核膜を持たない原核細胞で構成された細菌に対して高い殺菌性を示し、咽頭に棲息する細菌を確実に死滅させることができる。 That is, according to the gargle according to the present invention, since the effective chlorine concentration is 50 ppm or more and the abundance ratio of hypochlorous acid (HClO) is set to a pH range, it enters the epithelial cells of the pharynx and exists in the cytoplasm The virus can be reliably killed with hypochlorous acid.
On the other hand, since epithelial cells of the pharynx are eukaryotic cells and DNA is protected by the nuclear membrane, the effective chlorine concentration is set to 300 ppm or less, preferably 250 ppm or less, more preferably 200 ppm or less. It is possible to minimize the damage to the cells and to surely avoid the death of the epithelial cells.
Moreover, the above-mentioned hypochlorous acid shows high bactericidal activity against bacteria composed of prokaryotic cells not having a nuclear membrane, and can surely kill bacteria living in the pharynx.
　このように、次亜塩素酸は、咽頭の上皮細胞に対する傷害性を最小限にとどめつつ、咽頭の上皮細胞を構成する細胞質に侵入したウィルスや、咽頭に棲息する細菌だけを選択的に死滅させることが可能となる。 Thus, hypochlorous acid selectively kills only viruses that invade the cytoplasm that makes up the pharyngeal epithelial cells and bacteria that inhabit the pharynx, while minimizing damage to the pharyngeal epithelial cells. It becomes possible.
　また、次亜塩素酸（ＨＣｌＯ）は、アミノ基と結合しやすい性質があるが、ウィルスがカプシドと呼ばれるタンパク質で覆われているため、ウィルスを容易に破壊することができる。 Hypochlorous acid (HClO) has a property of easily binding to an amino group, but since the virus is covered with a protein called capsid, the virus can be easily destroyed.
　なお、炭酸水素ナトリウム（ＮａＨＣＯ3）は、次亜塩素酸（ＨＣｌＯ）がウィルスに接触するのをバイオフィルムが阻害している状況において、該バイオフィルムを破壊することにより、ウィルスへの次亜塩素酸（ＨＣｌＯ）の接触を可能にする役目も果たす。 In addition, sodium hydrogencarbonate (NaHCO 3 ) is a hypochlorous acid to virus by destroying the biofilm in a situation where the biofilm inhibits hypochlorous acid (HClO) from contacting the virus. It also serves to allow acid (HClO) contact.
　本発明において対象となるウィルスは、人体への感染の入口となる侵入部位、すなわち侵入門戸が上気道（口腔及び鼻腔から咽頭を経て喉頭に至るまでの範囲）であって、具体的には、インフルエンザウィルス、麻疹ウィルス、風疹ウィルス、水痘ウィルス、流行性耳下腺炎の病原体であるムンプスウィルス、ＳＡＲＳの病原体であるコロナウィルスを含む。 The target virus in the present invention is an invasion site serving as an entrance of infection to the human body, that is, the intrusion gate is the upper respiratory tract (range from the oral cavity and nasal cavity to the larynx through the pharynx), specifically, Influenza virus, measles virus, rubella virus, varicella virus, mumps virus which is a pathogen of epidemic parotitis, and coronavirus which is a pathogen of SARS.
　有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８となるように電気分解するためには、塩化ナトリウムを例えば２～５質量％添加するとともに、二酸化炭素についても、大気中に存在する二酸化炭素（３８０ｐｐｍ、日本の大気中二酸化炭素の年平均濃度、「理科年表（第２版環境編）」から抜粋）による分圧で自然に溶け込む程度の量では全く足りず、強制溶解によって二酸化炭素の溶解度を高める必要がある。 For electrolysis so that the effective chlorine concentration is 50 to 300 ppm and the pH is 6.3 to 8, for example, 2 to 5% by mass of sodium chloride is added, and carbon dioxide is also present in the atmosphere. Carbon (380ppm, annual average concentration of carbon dioxide in Japan, excerpted from "Science Chronology (2nd edition of the environment))" is not enough to dissolve naturally. It is necessary to increase the solubility of.
　すなわち、本明細書において二酸化炭素の強制溶解とは、二酸化炭素の溶解度を、自然に溶解し得る濃度（大気中に存在する二酸化炭素の分圧下における溶解度）よりも高くすることを意味するものとする。ここで、二酸化炭素を強制溶解させる具体的な方法としては、原液を、下記(a)～(d)のいずれかの方法で作製すればよいが、いずれの方法においても、塩酸、酢酸その他炭酸を除く酸は一切添加しない。したがって、原液組成条件は、塩化ナトリウムの添加量が主たるパラメータとなる。 That is, in this specification, forced dissolution of carbon dioxide means that the solubility of carbon dioxide is higher than the concentration at which it can be dissolved naturally (the solubility under the partial pressure of carbon dioxide present in the atmosphere). To do. Here, as a specific method for forcibly dissolving carbon dioxide, the stock solution may be prepared by any of the following methods (a) to (d). In any of these methods, hydrochloric acid, acetic acid or other carbonic acid is used. Do not add any acid except. Therefore, the main solution composition condition is the amount of sodium chloride added.
　(a)水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加し、該塩化ナトリウムの添加工程と同時に又はその前後に炭酸ガスを吹き込み、又はドライアイスを添加する。 (A) Water is passed through a reverse osmosis membrane, sodium chloride is added to the passing water, carbon dioxide gas is blown in or before or after the sodium chloride addition step, or dry ice is added.
　(b)純水又は蒸留水に塩化ナトリウムを添加し、該塩化ナトリウムの添加工程と同時に又はその前後に炭酸ガスを吹き込み、又はドライアイスを添加する。 (B) Sodium chloride is added to pure water or distilled water, and carbon dioxide gas is blown in or before or after the sodium chloride addition step, or dry ice is added.
  (c)水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加するとともに、通過水に接する二酸化炭素分圧を大気中の分圧よりも高くする。 (C) Pass water through the reverse osmosis membrane, add sodium chloride to the passing water, and make the partial pressure of carbon dioxide in contact with the passing water higher than the partial pressure in the atmosphere.
  (d)純水又は蒸留水に塩化ナトリウムを添加するとともに、純水又は蒸留水に接する二酸化炭素分圧を大気中の分圧よりも高くする。 (D) Sodium chloride is added to pure water or distilled water, and the partial pressure of carbon dioxide in contact with the pure water or distilled water is made higher than the partial pressure in the atmosphere.
　ここで、(a)及び(c)において原液の構成要素である水は、井戸水、水道水などを使用することが可能であり、あえて純水を使用する必要はない。但し、電解槽の電極損傷や電極反応の低下を未然に防止するためには、カルシウムイオン、マグネシウムイオンなどを含まない純水を使用した方がよいことは言うまでもない。 Here, the water that is a component of the stock solution in (a) and (c) can use well water, tap water, etc., and it is not necessary to use pure water. However, it goes without saying that it is better to use pure water that does not contain calcium ions, magnesium ions, etc., in order to prevent electrode damage in the electrolytic cell and reduction in electrode reaction.
　ここで、ｐＨを６．３～８としたのは、ｐＨ６．３以下では、含嗽剤を口腔内に含んだときに歯の脱灰の懸念があるからであり、さらにｐＨ６未満では、Ｈ2ＣＯ3、ＨＣＯ3 -及びＣＯ3 2-の濃度分率におけるＨＣＯ3 -の存在比率が低くなって、緩衝剤としての炭酸水素ナトリウムを生成させることが困難になり、ｐＨ８を上回ると、Ｃｌ2、ＨＣｌＯ及びＣｌＯ-の濃度分率におけるＨＣｌＯの存在比率が低下して、ウィルスを殺菌することができるだけの高濃度の次亜塩素酸を生成させることが困難になるからである。 Here, the reason the pH 6.3 to 8, in pH6.3 or less, because there is a concern demineralization of teeth when containing mouthwashes in the oral cavity, in even less than pH 6, H 2 CO 3, HCO 3 - and CO 3 2- in the HCO at concentrations fraction 3 - abundance ratio is lowered, and it becomes difficult to produce the sodium bicarbonate as a buffering agent, exceeds the pH 8, Cl 2 , HClO and ClO - because then reduced abundance ratio of HClO in the concentration fractions of, it becomes difficult to produce a high concentration of hypochlorous acid enough to be sterilized viruses.
　また、ｐＨを望ましくは７以上としたのは、う蝕病原菌によって産生される乳酸等に起因した口腔内の酸性化を防止することができるからである。 Also, the reason why the pH is desirably 7 or more is that it is possible to prevent acidification in the oral cavity caused by lactic acid produced by cariogenic pathogenic bacteria.
　また、有効塩素濃度を５０～３００ｐｐｍとしたのは、５０ｐｐｍ未満では、殺菌力が小さいためにウィルスを死滅させることが困難だからであり、３００ｐｍを上回ると、核膜によって細胞核が取り囲まれているとはいえ、人体の上皮細胞に傷害を与える懸念が出てくるからである。 The reason why the effective chlorine concentration is 50 to 300 ppm is that if it is less than 50 ppm, it is difficult to kill the virus because of its low bactericidal activity. If it exceeds 300 pm, the cell nucleus is surrounded by the nuclear membrane. Nonetheless, there are concerns about injury to epithelial cells in the human body.
　ここで、有効塩素濃度を望ましくは５０～２５０ｐｐｍとしたのは、上皮細胞への傷害の懸念をさらに小さくできるからであり、さらに望ましくは５０～２００ｐｐｍとしたのは、上皮細胞への傷害可能性を実質的にゼロにすることができるからである。 Here, the reason why the effective chlorine concentration is desirably 50 to 250 ppm is that the concern about the damage to the epithelial cells can be further reduced, and more desirably 50 to 200 ppm is the possibility of the damage to the epithelial cells. This is because it can be made substantially zero.
本実施形態に係る含嗽剤の生成装置を示した概略図。Schematic which showed the production | generation apparatus of the gargle concerning this embodiment. 変形例に係る含嗽剤の生成装置を示した概略図。Schematic which showed the production | generation apparatus of the gargle concerning the modification.
５１　　　　　　　　　　　　　含嗽剤の生成装置
５２　　　　　　　　　　　　　原液
３　　　　　　　　　　　　　　原液タンク
５　　　　　　　　　　　　　　電解槽
６　　　　　　　　　　　　　　吐出管
５７　　　　　　　　　　　　　希釈水
８　　　　　　　　　　　　　　希釈水タンク
１１　　　　　　　　　　　　　脱気モジュール
１４　　　　　　　　　　　　　３次生成水タンク 51 Generating device for gargle 52 Stock solution 3 Stock solution tank 5 Electrolysis tank 6 Discharge pipe 57 Dilution water 8 Dilution water tank 11 Deaeration module 14 Tertiary product water tank
　以下、本発明に係る含嗽剤及びその生成方法並びにその生成装置の実施の形態について、添付図面を参照して説明する。なお、従来技術と実質的に同一の部品等については同一の符号を付してその説明を省略する。 Hereinafter, embodiments of a gargle, a production method thereof, and a production apparatus thereof according to the present invention will be described with reference to the accompanying drawings. Note that components that are substantially the same as those of the prior art are assigned the same reference numerals, and descriptions thereof are omitted.
　本実施形態に係る含嗽剤は、次亜塩素酸（ＨＣｌＯ）及び炭酸水素ナトリウム（ＮａＨＣＯ3）を含み、有効塩素濃度を５０～３００ｐｐｍ、望ましくは５０～２５０ｐｐｍ、さらに望ましくは５０～２００ｐｐｍとするとともに、ｐＨを６．３以上８以下、望ましくは７以上８以下とし、咽頭に存在するウィルスの除去を用途とするものである。 The gargle according to this embodiment contains hypochlorous acid (HClO) and sodium hydrogen carbonate (NaHCO 3 ), and the effective chlorine concentration is 50 to 300 ppm, preferably 50 to 250 ppm, more preferably 50 to 200 ppm. The pH is 6.3 or more and 8 or less, preferably 7 or more and 8 or less, and the purpose is to remove viruses present in the pharynx.
　本実施形態に係る含嗽剤の生成装置を図１に示す。 FIG. 1 shows an apparatus for producing a gargle according to this embodiment.
　同図でわかるように、本実施形態に係る含嗽剤の生成装置５１は、原液５２を貯留する原液タンク３と、該原液タンクに連通接続されたストロークポンプ４と、該ストロークポンプに連通接続された電解槽５と、該電解槽に連通接続された吐出管６と、希釈水５７が貯留された希釈水タンク８とを備えるとともに、吐出管６の先端が希釈水タンク８に貯留された希釈水５７の水位以下となるように、吐出管６の先端位置に対する希釈水タンク８の設置位置を相対的に位置決めしてある。 As shown in the figure, the gargle generating apparatus 51 according to the present embodiment includes a stock solution tank 3 that stores a stock solution 52, a stroke pump 4 that is connected to the stock solution tank, and a communication pump that is connected to the stroke pump. The electrolytic cell 5, the discharge pipe 6 connected to the electrolytic tank, and the dilution water tank 8 in which the dilution water 57 is stored, and the tip of the discharge pipe 6 is diluted in the dilution water tank 8. The installation position of the dilution water tank 8 is relatively positioned with respect to the tip position of the discharge pipe 6 so as to be equal to or lower than the water level of the water 57.
　原液５２は、後述するいずれかの方法で作製するが、いずれの方法においても、塩酸、酢酸その他炭酸を除く酸は一切添加されていない。 The stock solution 52 is prepared by any of the methods described below, but no acid other than hydrochloric acid, acetic acid or other carbonic acid is added in any of the methods.
　希釈水５７は、井戸水、水道水、純水その他任意の水を使用することができるが、生成される含嗽剤のｐＨが上述した範囲になるようにｐＨを適宜選択する。 The dilution water 57 may be well water, tap water, pure water or any other water, but the pH is appropriately selected so that the pH of the gargle to be generated is in the above-mentioned range.
　本実施形態に係る生成装置５１はさらに、１次生成水が希釈水タンク８内において希釈水５７で希釈されてなる２次生成水６０に注水側が連通された脱気モジュール１１を備えており、該脱気モジュールは、真空ポンプ１２による減圧によって２次生成水６０の溶存酸素を除去するようになっているとともに、２次生成水６０から溶存酸素が除去された３次生成水を含嗽剤６３として貯留する３次生成水タンク１４を備えている。 The generation apparatus 51 according to the present embodiment further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 60 obtained by diluting the primary generation water with the dilution water 57 in the dilution water tank 8. The deaeration module is adapted to remove dissolved oxygen from the secondary product water 60 by decompression by the vacuum pump 12, and contains the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 60. As a third generation water tank 14 to be stored.
　なお、生成装置５１に用いるチューブ類あるいは必要に応じて適宜設ける電磁弁は、高濃度の次亜塩素酸による酸化で劣化のおそれがあるため、フッ素で形成するのが望ましい。 It should be noted that the tubes used in the generation device 51 or the electromagnetic valve provided as necessary may be deteriorated by oxidation with a high concentration of hypochlorous acid, so that it is desirable to form with fluorine.
　本実施形態に係る含嗽剤の生成装置５１を用いて含嗽剤６３を生成するには、３次生成水の有効塩素濃度が５０～３００ｐｐｍ、望ましくは５０～２５０ｐｐｍ、さらに望ましくは５０～２００ｐｐｍであり、かつｐＨが６．３～８、望ましくは７～８となるように、原液５２の組成条件（主として塩化ナトリウムの添加量）、電気分解時の動作条件（例えば電圧値や電流値）及び希釈条件（希釈倍率や希釈水のｐＨ）を定めるとともに、配合された原液５２を原液タンク３に貯留する。 In order to produce the gargle 63 using the gargle production apparatus 51 according to the present embodiment, the effective chlorine concentration of the tertiary product water is 50 to 300 ppm, desirably 50 to 250 ppm, more desirably 50 to 200 ppm. In addition, the composition conditions of the stock solution 52 (mainly the amount of sodium chloride added), the operating conditions during the electrolysis (eg voltage value and current value) and dilution so that the pH is 6.3 to 8, preferably 7 to 8. The conditions (dilution ratio and pH of dilution water) are determined, and the blended stock solution 52 is stored in the stock solution tank 3.
　塩化ナトリウムは例えば２～５質量％添加する。 Sodium chloride is added, for example, 2 to 5% by mass.
　二酸化炭素の溶解度を高めるためには、逆浸透膜に通された通過水、純水又は蒸留水を溶媒とし、該溶媒中に二酸化炭素を強制的に混入させることで二酸化炭素の溶解度を一時的に高める方法と、溶媒に接している二酸化炭素の分圧を上げる方法と、溶媒の温度を下げる方法とが考えられるが、電解時に生じる熱によって水温が上昇することを考えた場合、二酸化炭素を強制的に混入させる方法か、二酸化炭素の分圧を上げる方法のいずれかを選択するのが望ましい。 In order to increase the solubility of carbon dioxide, passing water, pure water or distilled water passed through a reverse osmosis membrane is used as a solvent, and carbon dioxide is forcibly mixed in the solvent to temporarily reduce the solubility of carbon dioxide. To increase the partial pressure of carbon dioxide in contact with the solvent, and to reduce the temperature of the solvent, it is possible to increase the water temperature due to heat generated during electrolysis. It is desirable to select either a method of forcibly mixing or a method of increasing the partial pressure of carbon dioxide.
　二酸化炭素の溶解度を一時的に高める方法としては、炭酸ガスの吹込みによる方法か、ドライアイスの添加による方法のいずれかにさらに分類することができる。ここで、一時的とは、溶媒に接している二酸化炭素の分圧が大気中に存在する二酸化炭素の分圧と等しいため、換言すれば、二酸化炭素の混入を大気圧下で行うため、一時的に強制圧入したとしても、空気に含まれる二酸化炭素の分圧との圧力平衡により、時間が経過するにしたがって、二酸化炭素の溶解度が減少する場合を指す。この場合、二酸化炭素の溶解度が低下しないうちに、速やかに電解処理を行う必要がある。 The method for temporarily increasing the solubility of carbon dioxide can be further classified into either a method by blowing carbon dioxide or a method by adding dry ice. Here, the term “temporary” means that the partial pressure of carbon dioxide in contact with the solvent is equal to the partial pressure of carbon dioxide present in the atmosphere. In other words, since carbon dioxide is mixed at atmospheric pressure, Even when forced press-fitting is performed, the solubility of carbon dioxide decreases with time due to pressure equilibrium with the partial pressure of carbon dioxide contained in the air. In this case, it is necessary to perform electrolytic treatment promptly before the solubility of carbon dioxide decreases.
　二酸化炭素の分圧を上げることで二酸化炭素の溶解度を高める方法としては、逆浸透膜を通過した通過水、純水又は蒸留水を溶媒として該溶媒を気密タンクに封入し、その気中空間に二酸化炭素を圧入するか、気密タンク内の溶媒に炭酸ガスを吹き込み若しくは溶媒にドライアイスを添加する方法を採用することができる。 As a method for increasing the solubility of carbon dioxide by increasing the partial pressure of carbon dioxide, the water is passed through a reverse osmosis membrane, pure water or distilled water is used as a solvent, and the solvent is sealed in an airtight tank. A method in which carbon dioxide is injected or carbon dioxide gas is blown into a solvent in an airtight tank or dry ice is added to the solvent can be employed.
　この場合、所定の二酸化炭素分圧で二酸化炭素を溶媒に溶かすとともに、その分圧を維持したまま、原液５２を電解槽５に送り込んで電気分解を行う必要があるため、二酸化炭素の分圧が低下しないよう、原液タンク３、ストロークポンプ４及び電解槽５を全体として気密に構成すればよい。 In this case, since it is necessary to dissolve carbon dioxide in a solvent at a predetermined partial pressure of carbon dioxide and to carry out electrolysis by feeding the stock solution 52 into the electrolytic cell 5 while maintaining the partial pressure, the partial pressure of carbon dioxide is reduced. What is necessary is just to comprise the undiluted | stock solution tank 3, the stroke pump 4, and the electrolytic vessel 5 as a whole so that it may not fall.
　以上まとめると、二酸化炭素の強制溶解は、以下に示す方法のいずれかを選択して作製する。 In summary, the forced dissolution of carbon dioxide is made by selecting one of the following methods.
　(a-1)　水道水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加するとともに、該塩化ナトリウムの添加工程と同時又はその前後に炭酸ガスを吹き込むことで、二酸化炭素を通過水に強制的に溶解させる。 (a-1) Tap water is passed through the reverse osmosis membrane, sodium chloride is added to the passing water, and carbon dioxide is blown into the passing water at the same time or before and after the sodium chloride adding step. Force to dissolve.
　(a-2)　水道水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加するとともに、該塩化ナトリウムの添加工程と同時又はその前後にドライアイスを添加することで、二酸化炭素を通過水に強制的に溶解させる。 (a-2) Tap water is passed through a reverse osmosis membrane, sodium chloride is added to the passing water, and carbon dioxide is passed through by adding dry ice simultaneously with or before and after the sodium chloride adding step. Forcibly dissolve.
　(b-1)　純水又は蒸留水に塩化ナトリウムを添加するとともに、該塩化ナトリウムの添加工程と同時又はその前後に炭酸ガスを吹き込むことで、二酸化炭素を強制的に溶解させる。 (B-1) While adding sodium chloride to pure water or distilled water, carbon dioxide is forcibly dissolved by blowing carbon dioxide at the same time as or before and after the sodium chloride addition step.
　(b-2)　純水又は蒸留水に塩化ナトリウムを添加するとともに、該塩化ナトリウムの添加工程と同時又はその前後にドライアイスを添加することで、二酸化炭素を強制的に溶解させる。 (B-2) While adding sodium chloride to pure water or distilled water, carbon dioxide is forcibly dissolved by adding dry ice simultaneously with or before and after the sodium chloride addition step.
　(c) 水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加するとともに、通過水に接する二酸化炭素分圧を大気中の分圧よりも高くすることによって、大気中の二酸化炭素分圧での溶解度よりも高い溶解度で二酸化炭素を通過水に溶解させる。 (c) Passing the brine through the reverse osmosis membrane, adding sodium chloride to the passing water, and increasing the partial pressure of carbon dioxide in contact with the passing water to be higher than the partial pressure in the atmosphere. Carbon dioxide is dissolved in the passing water with a solubility higher than that in
　(d) 純水又は蒸留水に塩化ナトリウムを添加するとともに、純水又は蒸留水に接する二酸化炭素分圧を大気中の分圧よりも高くすることによって、大気中の二酸化炭素分圧での溶解度よりも高い溶解度で二酸化炭素を通過水に溶解させる。 (d) 塩 化 ナ ト リ ウ ム Solubility at atmospheric carbon dioxide partial pressure by adding sodium chloride to pure water or distilled water and making the partial pressure of carbon dioxide in contact with pure water or distilled water higher than the partial pressure in the atmosphere Carbon dioxide is dissolved in the passing water with higher solubility.
　逆浸透膜に通す水は、どのような性状のものでもよいが、逆浸透膜やそれを使った浄水器の負担を軽減し、あるいは捨て水の量をなるべく少なくするという意味では、ある程度浄化された水が望ましい。例えば、地下水、水道水又は市販されているミネラルウォータ（市販水）を使用することができる。以下、本実施形態では、逆浸透膜に通す水として水道水を用いるものとする。 The water that passes through the reverse osmosis membrane may be of any property, but it is purified to some extent in the sense of reducing the burden on the reverse osmosis membrane and the water purifier using it, or reducing the amount of waste water as much as possible. Water is desirable. For example, ground water, tap water, or commercially available mineral water (commercial water) can be used. Hereinafter, in this embodiment, tap water is used as the water that passes through the reverse osmosis membrane.
　水道水を逆浸透膜に通すことで原液５２を作製する場合には、逆浸透膜を備えた浄水器がいくつかのメーカーから市販されているので、それらから適宜選択し利用すればよい。また、二酸化炭素の分圧が高い環境下で通過水、純水又は蒸留水に二酸化炭素を溶解させる場合には、従来公知の二酸化炭素溶解装置を適宜利用することができる。 When the stock solution 52 is produced by passing tap water through a reverse osmosis membrane, water purifiers equipped with a reverse osmosis membrane are commercially available from several manufacturers. In addition, when carbon dioxide is dissolved in passing water, pure water or distilled water in an environment where the partial pressure of carbon dioxide is high, a conventionally known carbon dioxide dissolving apparatus can be used as appropriate.
　原液５２を作製したならば、次に、かかる原液５２を含嗽剤１バッチ分に相当する量だけ計量し原液タンク３に貯留するとともに、同じく含嗽剤１バッチ分に相当する量の希釈水５７を希釈水タンク８に貯留する。含嗽剤１バッチ分に相当する希釈水５７の量は、希釈倍率や希釈水のｐＨに応じて適宜定めればよい。 Once the stock solution 52 has been prepared, the stock solution 52 is then weighed in an amount corresponding to one batch of gargle and stored in the stock solution tank 3, and diluted water 57 of an amount corresponding to one batch of gargle is also added. Stored in the dilution water tank 8. The amount of the dilution water 57 corresponding to one batch of the gargle may be appropriately determined according to the dilution rate and the pH of the dilution water.
　次に、原液５２をストロークポンプ４で電解槽５に送り、定められた動作条件で電解槽５を動作させ、原液５２を電気分解する。 Next, the stock solution 52 is sent to the electrolytic cell 5 by the stroke pump 4, and the electrolytic cell 5 is operated under predetermined operating conditions to electrolyze the stock solution 52.
　次に、電解槽５内で生成された１次生成水を、該電解槽に連通接続された吐出管６を介して、予め希釈水タンク８に貯留された希釈水５７内に注入する。 Next, the primary generated water generated in the electrolytic cell 5 is injected into the diluted water 57 previously stored in the diluted water tank 8 through the discharge pipe 6 connected to the electrolytic cell.
　ここで、希釈水タンク８は、吐出管６の先端位置が希釈水タンク８の中に貯留された希釈水５７の水位以下となるように、その設置位置を相対的に位置決めしてある。 Here, the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 57 stored in the dilution water tank 8.
　そのため、１次生成水は、空気（外気）と接触することなく、吐出管６を介して希釈水５７内に注入される。また、１次生成水は、予め計量された希釈水５７に注入されるいわばバッチ方式で注入されることになるため、従来のような配管内混合とは異なり、１次生成水は、希釈水５７に均質に混合される。 Therefore, the primary product water is injected into the dilution water 57 through the discharge pipe 6 without coming into contact with air (outside air). In addition, since the primary product water is injected into the diluting water 57 weighed in advance in a so-called batch system, the primary product water is diluted with the dilution water unlike conventional mixing in the pipe. 57 is mixed homogeneously.
　次に、２次生成水６０を脱気モジュール１１に通すことにより、溶存ガス、特に溶存酸素が除去された３次生成水を生成し、これを含嗽剤３３として３次生成水タンク１４に貯留する。 Next, the secondary generated water 60 is passed through the degassing module 11 to generate tertiary generated water from which dissolved gas, particularly dissolved oxygen is removed, and this is stored in the tertiary generated water tank 14 as a gargle 33. To do.
　本実施形態に係る含嗽剤６３を用いて咽頭に存在するウィルスを除去するには、含嗽剤を口腔内に含んで数秒～数十秒間、含嗽すればよい。 In order to remove the virus present in the pharynx using the gargle 63 according to the present embodiment, the gargle may be contained in the oral cavity for several seconds to several tens of seconds.
　このようにすると、炭酸水素ナトリウム（ＮａＨＣＯ3）によって、含嗽剤全体のｐＨを次亜塩素酸（ＨＣｌＯ）の存在比率が高い６．３～８の範囲に維持しつつ、含嗽剤６３に含まれる次亜塩素酸（ＨＣｌＯ）の殺菌力で咽頭に存在するウィルスを速やかに除去する一方、炭酸水素ナトリウム（ＮａＨＣＯ3）による緩衝作用によって人体に対する安全を確保する。 In this case, the pH of the entire gargle is maintained in the range of 6.3 to 8 in which the abundance ratio of hypochlorous acid (HClO) is kept high by sodium hydrogen carbonate (NaHCO 3 ), and is contained in the gargle 63. While the virus present in the pharynx is rapidly removed by the bactericidal power of hypochlorous acid (HClO), the safety to the human body is ensured by the buffer action by sodium hydrogen carbonate (NaHCO 3 ).
　以上説明したように、本実施形態に係る含嗽剤６３及びその生成方法並びに生成装置５１によれば、塩化ナトリウム及び二酸化炭素が添加された水溶液を原液とし、該原液を、有効塩素濃度が５０～３００ｐｐｍ、望ましくは５０～２５０ｐｐｍ、さらに望ましくは５０～２００ｐｐｍ、ｐＨが６．３～８、望ましくは７～８となるように電気分解するようにしたので、咽頭に存在するウィルスを殺菌できるだけの高濃度の次亜塩素酸と、次亜塩素酸の存在比率が高くなるｐＨ環境を維持できるだけの炭酸水素ナトリウム（ＮａＨＣＯ3）とを生成することが可能となる。 As described above, according to the gargle 63, the production method thereof, and the production apparatus 51 according to this embodiment, an aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution, and the stock solution has an effective chlorine concentration of 50 to 50. 300 ppm, preferably 50-250 ppm, more preferably 50-200 ppm, and the pH is 6.3-8, preferably 7-8. Electrolysis is performed so that the virus present in the pharynx can be sterilized. It becomes possible to produce hypochlorous acid having a concentration and sodium hydrogen carbonate (NaHCO 3 ) capable of maintaining a pH environment where the abundance ratio of hypochlorous acid is high.
　また、本実施形態に係る含嗽剤６３の生成方法及び生成装置５１によれば、二酸化炭素を強制的に溶解させるようにしたので、高濃度の炭酸水素ナトリウムを生成させてｐＨ変動に対する抵抗性（緩衝性）を高めることができるとともに、塩酸や酢酸といった酸をわざわざ添加する必要がないので、無味無臭の含嗽剤を生成することが可能であり、有効塩素濃度が３００ｐｐｍであっても、何ら不快感を与えることなく、かつ数秒～数十秒程度という短時間の含嗽で咽頭のウィルスを除去することができるという顕著な作用効果を奏する。 Moreover, according to the production method and the production apparatus 51 of the gargle 63 according to the present embodiment, since carbon dioxide is forcibly dissolved, a high concentration sodium hydrogen carbonate is produced and resistance to pH fluctuation ( It is possible to produce a tasteless and odorless gargle because there is no need to add acid such as hydrochloric acid or acetic acid, and even if the effective chlorine concentration is 300 ppm, there is no problem. There is a remarkable effect that the virus in the pharynx can be removed without giving pleasure and with a short period of rinsing for several seconds to several tens of seconds.
　また、本実施形態に係る含嗽剤６３によれば、有効塩素濃度を５０ｐｐｍ以上でかつ次亜塩素酸（ＨＣｌＯ）の存在比率が高いｐＨ範囲としたので、核膜を持たない原核生物である細菌や、細胞を構成する細胞質に侵入したウィルスを次亜塩素酸（ＨＣｌＯ）の殺菌作用によって速やかに死滅させる一方、有効塩素濃度を３００ｐｐｍ以下、望ましくは２５０ｐｐｍ以下、さらに望ましくは２００ｐｐｍ以下としたので、核膜による細胞核の保護作用が損なわれることはなく、かくして人体の上皮細胞に対する傷害性を最小限にとどめることができる。 In addition, according to the gargle 63 according to the present embodiment, since the effective chlorine concentration is 50 ppm or more and the pH ratio is high in the ratio of hypochlorous acid (HClO), bacteria that are prokaryotes having no nuclear membrane In addition, while the virus that has entered the cytoplasm constituting the cells is quickly killed by the bactericidal action of hypochlorous acid (HClO), the effective chlorine concentration is 300 ppm or less, preferably 250 ppm or less, more preferably 200 ppm or less. The protective action of the cell nucleus by the nuclear membrane is not impaired, and thus the damage to the epithelial cells of the human body can be minimized.
　すなわち、本実施形態に係る含嗽剤６３によれば、有効塩素濃度を５０～３００ｐｐｍ、望ましくは５０～２５０ｐｐｍ、さらに望ましくは５０～２００ｐｐｍとすることにより、咽頭の上皮細胞には傷害を与えず、細菌や細胞に侵入したウィルスだけを選択的に攻撃して死滅させることができる。 That is, according to the gargle 63 according to the present embodiment, the effective chlorine concentration is 50 to 300 ppm, preferably 50 to 250 ppm, more preferably 50 to 200 ppm, so that the epithelial cells of the pharynx are not damaged, Only viruses that have entered bacteria and cells can be selectively attacked and killed.
　また、本実施形態に係る含嗽剤６３によれば、次亜塩素酸（ＨＣｌＯ）が、カプシドに存在するアミノ基と結合するため、ウィルスを容易に破壊することができる。 Moreover, according to the gargle 63 according to the present embodiment, hypochlorous acid (HClO) binds to an amino group present in the capsid, so that the virus can be easily destroyed.
　本実施形態では、２次生成水６０中の溶存ガスを脱気モジュール１１を用いて除去するようにしたが、２次生成水６０中の溶存ガスの濃度が低いために発泡現象が起きる懸念がないのであれば、溶存ガスを除去する工程を省略してもかまわない。かかる場合には、２次生成水６０がすなわち含嗽剤となる。 In the present embodiment, the dissolved gas in the secondary product water 60 is removed using the degassing module 11, but there is a concern that a foaming phenomenon may occur because the concentration of the dissolved gas in the secondary product water 60 is low. If not, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 60 becomes a gargle.
　図２は、溶存ガスの除去工程を省略する際に用いる生成装置５１ａを示した図であり、脱気モジュール１１、真空ポンプ１２及び３次生成水タンク１４を生成装置２１から省略してある。 FIG. 2 is a diagram showing a generating device 51a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generating device 21.
　また、本実施形態では、含嗽剤１バッチ分に対応する量の原液５２と希釈水５７とを計量し、それぞれを原液タンク３と希釈水タンク８に予め貯留するようにしたが、これに代えて、含嗽剤１バッチ分よりも多い量、例えば数バッチ分に対応する量の原液５２を原液タンク３に予め貯留しておくのであれば、含嗽剤１バッチ分に対応する原液５２の量をそのつど計量するための水位計測手段を備えるようにすればよい。かかる水位計測手段は、例えば超音波センサや電極式センサ等で適宜構成することができる。 Further, in this embodiment, the stock solution 52 and the dilution water 57 corresponding to one batch of the gargle are weighed and stored in the stock solution tank 3 and the dilution water tank 8 in advance. If the stock solution 52 in an amount larger than one batch of the gargle, for example, an amount corresponding to several batches is stored in the stock solution tank 3 in advance, the amount of the stock solution 52 corresponding to one batch of the gargle is determined. What is necessary is just to provide the water level measurement means for measuring each time. Such water level measuring means can be appropriately configured by, for example, an ultrasonic sensor, an electrode type sensor or the like.
　また、本実施形態では、原液を電気分解した後、これを希釈して含嗽剤を生成するようにしたが、これに代えて、原液を希釈し、しかる後、該希釈水を電気分解して含嗽剤を得るようにしてもかまわない。 In the present embodiment, the stock solution is electrolyzed and then diluted to produce a gargle, but instead, the stock solution is diluted and then the diluted water is electrolyzed. A gargle may be obtained.
　また、本実施形態では、原液を電気分解した後、これを希釈して含嗽剤を生成するようにしたが（後希釈）、これに代えて、原液を希釈し、しかる後、該希釈水を電気分解して含嗽剤を得るようにしてもかまわない（前希釈）。なお、かかる変形例の場合においては、希釈水タンク８を省略し、これに代えて、希釈された原液を貯留するための希釈原液タンクを原液タンク３と電解槽５との間に別途備えればよい。 In the present embodiment, the stock solution is electrolyzed and then diluted to produce a gargle (post-dilution). Instead, the stock solution is diluted, and then the diluted water is added. The gargle may be obtained by electrolysis (pre-dilution). In the case of such a modified example, the dilution water tank 8 is omitted, and instead, a diluted stock solution tank for storing the diluted stock solution is separately provided between the stock solution tank 3 and the electrolytic cell 5. That's fine.
（含嗽剤の生成）
　まず、逆浸透膜を備えた浄水器に水道水を注水し、次いで、逆浸透膜を通過した水に３質量％の塩化ナトリウムを添加するとともに、ドライアイスを添加して原液とし、次いで、この原液を５倍に希釈した（前希釈）。 (Generation of gargle)
First, tap water is poured into a water purifier equipped with a reverse osmosis membrane, then 3% by mass of sodium chloride is added to the water that has passed through the reverse osmosis membrane, and dry ice is added to obtain a stock solution. The stock solution was diluted 5 times (pre-dilution).
　次に、希釈した原液を電解槽で電気分解して含嗽剤とした。 Next, the diluted stock solution was electrolyzed in an electrolytic cell to obtain a gargle.
　電解槽は、葵エンジニヤリング株式会社が製造し、野口歯科医学研究所株式会社が「パーフェクトペリオ」の商品名で販売している電解中性水生成装置の電解槽を用いた。 The electrolytic cell used was an electrolytic neutral water generating device manufactured by Sakai Engineering Co., Ltd. and sold under the trade name “Perfect Perio” by Noguchi Dental Institute.
　以上のプロセスで電気分解を行ったところ、ｐＨ６．３～８の範囲内で有効塩素濃度が５０～３００ｐｐｍの含嗽剤を生成することができた。なお、含嗽剤中における有効塩素の濃度を測定するにあたっては、２００ｐｐｍを越える濃度測定が可能な計器や試験紙あるいは試薬がなかったため、二倍希釈を二度繰り返すことで有効塩素濃度を計測した。 When electrolysis was performed by the above process, it was possible to produce a gargle having an effective chlorine concentration of 50 to 300 ppm within a pH range of 6.3 to 8. In measuring the concentration of effective chlorine in the gargle, there was no meter, test paper, or reagent capable of measuring concentrations exceeding 200 ppm. Therefore, the effective chlorine concentration was measured by repeating twice the dilution twice.
（含嗽剤の生成に関する実験）
1)原液
　原液として、以下の４つの試験溶液を準備した。
　試験溶液Ａ；
　大気圧下かつ室温下で蒸留水にドライアイス５％（w/v）を添加することで、該蒸留水にドライアイスを構成する二酸化炭素を溶解させ（飽和炭酸水）、しかる後、塩化ナトリウムを０．６％（w/v）を溶解させた。 (Experiment on generation of gargle)
1) Stock solution The following four test solutions were prepared as stock solutions.
Test solution A;
By adding 5% (w / v) of dry ice to distilled water at atmospheric pressure and at room temperature, carbon dioxide constituting the dry ice is dissolved in the distilled water (saturated carbonated water). 0.6% (w / v) was dissolved.
　試験溶液Ｂ；
　試験溶液Ａの中間生成物である飽和炭酸水を蒸留水で５倍に希釈し、しかる後、塩化ナトリウムを０．６％（w/v）を溶解させた。 Test solution B;
Saturated carbonated water, which is an intermediate product of test solution A, was diluted 5-fold with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
　試験溶液Ｃ；
　試験溶液Ａの中間生成物である飽和炭酸水を蒸留水で１０倍に希釈し、しかる後、塩化ナトリウムを０．６％（w/v）を溶解させた。 Test solution C;
Saturated carbonated water, which is an intermediate product of the test solution A, was diluted 10 times with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
　試験溶液Ｄ；
　大気圧下かつ室温下で蒸留水を大気に曝露することで、該蒸留水に空気中の二酸化炭素を溶解させ、次いで、塩化ナトリウムを０．６％（w/v）を溶解させた。 Test solution D;
By exposing distilled water to the atmosphere under atmospheric pressure and room temperature, carbon dioxide in the air was dissolved in the distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
2)試験方法
　無隔膜タイプの電解槽に上記原液を４Ｌ投入し、２．８Ａの直流電流で電気分解を行った。 2) Test method 4 L of the above stock solution was put into a non-membrane type electrolytic cell, and electrolysis was performed with a direct current of 2.8 A.
3)結果
　試験結果を表１に示す。
Figure JPOXMLDOC01-appb-T000001
 3) Results Table 1 shows the test results.
Figure JPOXMLDOC01-appb-T000001
　同表でわかるように、飽和炭酸水を使った試験溶液Ａ～試験溶液Ｃでは、次亜塩素酸及び炭酸水素ナトリウムが十分な濃度で存在し得るｐＨ範囲、すなわち６～８となっている。それに対し、空気中の二酸化炭素を自然溶解させた試験溶液Ｄでは、ｐＨが９．２となった。したがって、空気中の二酸化炭素を自然溶解させる方法では、次亜塩素酸及び炭酸水素ナトリウムの両方を十分な濃度で生成することは困難であろうと思われる。 As can be seen from the table, Test Solution A to Test Solution C using saturated carbonated water have a pH range in which hypochlorous acid and sodium bicarbonate can be present in sufficient concentrations, that is, 6 to 8. On the other hand, the pH of the test solution D in which carbon dioxide in the air was naturally dissolved was 9.2. Therefore, it seems that it is difficult to produce both hypochlorous acid and sodium hydrogen carbonate at a sufficient concentration by the method of spontaneously dissolving carbon dioxide in the air.

Claims (12)

  1. 有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８であって、次亜塩素酸及び炭酸水素ナトリウムを含み、咽頭に存在するウィルスの除去を用途としたことを特徴とする含嗽剤。 A gargle having an effective chlorine concentration of 50 to 300 ppm, a pH of 6.3 to 8, and containing hypochlorous acid and sodium hydrogen carbonate, and used for removing viruses present in the pharynx.
  2. 前記有効塩素濃度を５０～２５０ｐｐｍとした請求項１記載の含嗽剤。 The gargle according to claim 1, wherein the effective chlorine concentration is 50 to 250 ppm.
  3. 前記有効塩素濃度を５０～２００ｐｐｍとした請求項１記載の含嗽剤。 The gargle according to claim 1, wherein the effective chlorine concentration is 50 to 200 ppm.
  4. ｐＨを、前記６．３～８に代えて、７～８とした請求項１乃至請求項３のいずれか一記載の含嗽剤。 The gargle according to any one of claims 1 to 3, wherein the pH is 7 to 8 instead of 6.3 to 8.
  5. 咽頭に存在するウィルスの除去を用途とした含嗽剤の生成方法であって、塩化ナトリウム及び二酸化炭素が添加された水溶液を原液とし、該原液を、有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８となるように電気分解することにより、所定濃度の次亜塩素酸及び炭酸水素ナトリウムを生成させる含嗽剤の生成方法であって、前記原液を、
    　水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加し、該塩化ナトリウムの添加工程と同時に又はその前後に炭酸ガスを吹き込み又はドライアイスを添加することによって、
    　純水又は蒸留水に塩化ナトリウムを添加し、該塩化ナトリウムの添加工程と同時に又はその前後に炭酸ガスを吹き込み又はドライアイスを添加することによって、
    　水を逆浸透膜に通し、その通過水に塩化ナトリウムを添加するとともに、前記通過水に接する二酸化炭素分圧を大気中の分圧よりも高くすることによって、又は、
    　純水又は蒸留水に塩化ナトリウムを添加するとともに、前記純水又は前記蒸留水に接する二酸化炭素分圧を大気中の分圧よりも高くすることによって、
    それぞれ作製することを特徴とする含嗽剤の生成方法。     A method for producing a gargle for the purpose of removing viruses present in the pharynx, wherein an aqueous solution containing sodium chloride and carbon dioxide is used as a stock solution, and the stock solution has an effective chlorine concentration of 50 to 300 ppm and a pH of 6. A method for producing a gargle which generates a predetermined concentration of hypochlorous acid and sodium hydrogen carbonate by electrolysis to 3 to 8, wherein the stock solution comprises:
    By passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, blowing carbon dioxide or adding dry ice simultaneously with or before and after the sodium chloride addition step,
    By adding sodium chloride to pure water or distilled water, blowing carbon dioxide or adding dry ice simultaneously with or before and after the sodium chloride addition step,
    By passing water through a reverse osmosis membrane, adding sodium chloride to the passing water, and making the partial pressure of carbon dioxide in contact with the passing water higher than the partial pressure in the atmosphere, or
    While adding sodium chloride to pure water or distilled water, by making the carbon dioxide partial pressure in contact with the pure water or the distilled water higher than the partial pressure in the atmosphere,
    A method for producing a gargle, characterized in that each is produced.
  6. 前記有効塩素濃度を５０～２５０ｐｐｍとした請求項５記載の含嗽剤。 The gargle according to claim 5, wherein the effective chlorine concentration is 50 to 250 ppm.
  7. 前記有効塩素濃度を５０～２００ｐｐｍとした請求項５記載の含嗽剤。 The gargle according to claim 5, wherein the effective chlorine concentration is 50 to 200 ppm.
  8. ｐＨを前記６．３～８に代えて、７～８とした請求項５乃至請求項７のいずれか一記載の含嗽剤の生成方法。 The method for producing a gargle according to any one of claims 5 to 7, wherein the pH is changed to 7 to 8 instead of 6.3 to 8.
  9. 咽頭に存在するウィルスの除去を用途とした含嗽剤を生成する装置であって、塩化ナトリウム及び二酸化炭素が添加された原液を貯留する原液タンクと、該原液タンクに連通接続され前記原液を電気分解する電解槽とを備え、該電解槽は、前記原液を電気分解することによって、有効塩素濃度が５０～３００ｐｐｍ、ｐＨが６．３～８であって、次亜塩素酸及び炭酸水素ナトリウムを含む含嗽剤を生成するようになっていることを特徴とする含嗽剤の生成装置。 An apparatus for producing a gargle for the purpose of removing viruses present in the pharynx, a stock solution tank for storing a stock solution to which sodium chloride and carbon dioxide have been added, and an electrolysis of the stock solution connected to the stock solution tank The electrolytic cell electrolyzes the stock solution to have an effective chlorine concentration of 50 to 300 ppm, a pH of 6.3 to 8, and containing hypochlorous acid and sodium hydrogen carbonate. An apparatus for producing a gargle, wherein the gargle is produced.
  10. 前記有効塩素濃度を５０～２５０ｐｐｍとした請求項９記載の含嗽剤の生成装置。 The apparatus for producing a gargle according to claim 9, wherein the effective chlorine concentration is 50 to 250 ppm.
  11. 前記有効塩素濃度を５０～２００ｐｐｍとした請求項９記載の含嗽剤の生成装置。 The apparatus for producing a gargle according to claim 9, wherein the effective chlorine concentration is 50 to 200 ppm.
  12. ｐＨを前記６．３～８に代えて、７～８とした請求項９乃至請求項１１のいずれか一記載の含嗽剤の生成装置。 The apparatus for producing a gargle according to any one of claims 9 to 11, wherein the pH is changed to 7 to 8 instead of 6.3 to 8.
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