JPWO2007072697A1 - Bactericidal water, method for producing the same, and production device - Google Patents

Abstract

Periodontal bacteria that inhabit deep in the periodontal pocket at a pH satisfying both decalcification and bactericidal activity are surely killed. The sterilizing water according to the present invention has a concentration of hypochlorous acid (HCLO) of 201 to 600 ppm and a pH of 5.6 to 7, and is used for sterilization of periodontal disease bacteria that reside in periodontal pockets. It is. Here, the reason for setting it to 201 ppm or more is not only to retain the oxidizing power to sterilize the periodontal disease bacteria when reaching deep in the periodontal pocket, but also to completely sterilize the periodontal disease bacteria within a few seconds. .

Description

  The present invention relates to a sterilizing water that sterilizes periodontal disease bacteria that mainly reside deep in a periodontal pocket as a subgingival plaque, a method for generating the same, and a generating apparatus.

  Among the bacteria detected in the oral cavity, dental plaque bacteria are roughly classified into epigingival plaque using saliva as a nutrient source and subgingival plaque using gingival crevicular fluid (blood component) as a nutrient source. The submarine plaque contains periodontal disease bacteria that cause periodontal disease.

  In gingivitis and periodontal disease, first, plaque adheres to the gingival crevice between the teeth and the gingiva, and this plaque causes gingivitis, and this gingivitis progresses between the teeth and gingiva. Deep grooves called periodontal pockets are formed, and periodontal disease develops.

  As the condition progresses from gingivitis to periodontal disease, the teeth become wobbled and eventually the teeth will come off, but since periodontal disease bacteria are carried throughout the body through the blood, bacteremia, Not only does it cause various diseases such as myocardial infarction, angina pectoris, bacterial endocarditis, arteriosclerosis, hypertension, pneumonia, and sepsis, but it also worsens the pathology of diabetes, premature birth, and premature infants (low It has recently been elucidated that it can cause childbirth.

  On the other hand, it is said that periodontal disease is infected by about 80% in generations over 30 years old. As mentioned above, periodontal disease is a life-threatening infection and appropriate for periodontal disease. Establishing appropriate treatments has become an urgent task.

  As one of the treatment methods for periodontal disease, ozone treatment is known. Ozone treatment itself has been widely used in the medical field because of its excellent sterilizing ability. However, research has also started to apply it to the oral cavity using the high sterilizing ability of ozone water.

  However, with regard to ozone therapy, although there are reports of bactericidal activity against Streptococcus mutans, a type of streptococci, Streptococcus mutans, it is preferred that supragingival plaque is the main palliative site. Even if the temperate Streptococcus mutans can be killed, the unstable ozone that is easily broken down into water and oxygen instantly is an anaerobic pathogen that lives deep in the periodontal pocket It is unclear whether it can be killed, but rather there is a great concern that ozone will decompose and inactivate before reaching the bottom of the periodontal pocket.

  In addition, in order to expect a sufficient bactericidal effect with ozone therapy, an ozone concentration of at least 4 ppm is required. At such a concentration, ozone gas volatilized from the ozone water causes irritation to the upper respiratory tract, headache, chest Not only does it cause symptoms such as pain and cough (gumbling, cough), but there are also concerns that it may cause an increase in pulse and anesthesia symptoms, so it can be said that the therapy still has problems in terms of safety.

  As a second treatment, there is a wide range of treatments that kill periodontal disease bacteria by administration of antibiotics. However, treatment with antibiotics has a risk of emergence of resistant bacteria. Is not perfect.

  In addition, plaque attached to the surface of the teeth is not suspended in the biofilm, but is blocked by the biofilm made of the exopolysaccharide produced by itself, blocking the host defense mechanisms and antibiotics that are the enemy. Keep growing slowly while maintaining a protected state. This is a so-called biofilm infection, which makes treatment with antibiotics difficult.

In addition, the bactericidal properties of sodium hypochlorite (NaOCL, sodium hypochlorite) have been widely known in the past, but what actually has bactericidal power is hypochlorous acid (which is produced by hydrolysis ( HCLO), such hypochlorous acid can hardly be present in an aqueous solution at a high pH, and instead changes its form to hypochlorite ion (CLO ⁻ ) having a weak sterilizing power, and in the first place. High pH is highly irritating and may corrode human tissue, so it cannot be used in the oral cavity. If the pH is lowered too much, extremely toxic chlorine gas is generated.

  Therefore, sodium hypochlorite (NaOCL) is prepared by adding acid beforehand to lower the pH, disinfecting hands, disinfecting fruits and vegetables, disinfecting food production lines, disinfecting bathrooms, etc. At present, it is limited to disinfection, bleach, sterilization of waste water after sewage treatment.

  In addition, weakly acidic water in which sodium hypochlorite and hydrochloric acid are diluted and mixed to make the pH weakly acidic with a pH of 5.5 to 6.5 is commercially available. It is not premised on the use of, and it has not been demonstrated for safety or efficacy as a treatment for periodontal disease.

JP-A-9-183706 JP-A-10-87462 JP 2001-327975 A JP-A-6-292892 JP 10-314746 A JP-A 63-286148 JP 5-76550 A JP-A-4-994785 JP 7-313982 A JP-A-8-19784 JP-A-8-108182

  Here, Patent Document 1 discloses hypochlorous acid sterilized water used by including it in the oral cavity. As an example, hydrochloric acid is added to a sodium chloride solution to perform electrolysis, and the pH is 6.5. It is described that sterilizing water having a residual chlorine concentration of 50 ppm can be produced. Patent Document 2 discloses oral cleansing water having a hypochlorous acid concentration of 5 to 55 ppm.

  However, the present applicant's clinical trial revealed that such sterilized water and washing water cannot completely kill an anaerobic pathogen that kills the periodontal disease bacteria that inhabit deep in the periodontal pocket. In addition, in the claims of Patent Document 1, the pH range is 3 to 8, but at least in the range of about pH 3 to pH 5, there is a strong risk of decalcification, and it is used in the oral cavity. Can not.

In Patent Document 3, sodium chloride (NaCL), acetic acid and water are used as a stock solution, and the stock solution is electrolyzed to produce hypochlorite ions (CLO ⁻ ), which are used as dental tap water. As described above, hypochlorite ion (CLO ⁻ ) is not only less sterilizing than hypochlorous acid (HCLO), but also hypochlorite ion ( Using CLO ⁻ ) has too much effect on human tissue.

  Patent Document 4 discloses that a cooking environment is prepared by using sodium chloride (NaCL), an inorganic acid and water as a stock solution, electrolyzing the stock solution to generate active oxygen, and hypochlorous acid generated together with active oxygen. Although it is described that it can be used in various fields such as sanitary water for hand hygiene, hand washing, food materials, and hand towels, as well as food processing and distribution fields, it does not describe any effects on periodontal disease bacteria. There is no mention of any application in the dental field.

  In addition, Patent Document 5 discloses a new stock solution composition to solve the problems not solved in Patent Documents 6 to 9, that is, the pH-related problems when used as oral cleaning water. It is disclosed that sterilized water composed of hypochlorous acid (HCLO) of about 30 ppm can be generated by electrolysis (Table 2 and FIG. 3), and can be used for periodontal disease prevention. Although the disclosure has been made (paragraph number 28), the bacterial cells actually tested do not contain periodontal disease bacteria, and their effects on periodontal disease bacteria are not clear, as described above. It is impossible to kill periodontal disease bacteria with sterilized water.

  Further, Patent Documents 10 and 11 are not premised on use in the oral cavity, and it is unclear whether or not there is an effect of killing dental plaque in the first place as well as periodontal disease bacteria.

  As described above, the periodontopathic bacteria threaten the danger of life. However, in the publicly known literature, it is not clarified at all how to kill the periodontal pathogens living deep in the periodontal pocket. In addition, sterilized water containing hypochlorous acid (HCLO) is mainly used only for sterilization and disinfection of hands and production lines, and actually kills periodontal disease bacteria living in periodontal pockets. It has been clarified by the applicant's clinical trial that this is impossible.

  In addition, in the conventional method for producing sterilizing water, hydrochloric acid and acetic acid have to be added, pH control becomes difficult, and in addition to components contained in water from the beginning, there are various types other than hypochlorous acid (HCLO). Cause the generation of irritating substances, especially substances that stimulate the senses of taste and olfaction, and there was a natural limit when used in the oral cavity.

  The present invention has been made in consideration of the above-described circumstances, and is a sterilized water that can surely kill periodontal disease bacteria that inhabit deep in the periodontal pocket at a pH that satisfies both decalcification and sterilizing power. Another object of the present invention is to provide a generation method and a generation apparatus thereof.

  It is another object of the present invention to provide a method and an apparatus for generating sterilized water that can be easily pH-controlled and do not generate substances that stimulate taste and smell.

  In order to achieve the above object, as described in claim 1, the sterilizing water according to the present invention is a sterilizing water containing hypochlorous acid (HCLO), wherein the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm. In addition, the pH is set to 5.6 to 7, and the sterilization of periodontal disease bacteria that inhabit the periodontal pocket is used.

  The sterilizing water according to the present invention is 400 to 600 ppm instead of 201 to 600 ppm.

  The sterilizing water according to the present invention is 6.3 to 6.7 instead of 5.6 to 7 described above.

  The sterilizing water according to the present invention is 5.6 to 6.3 in place of the above 5.6 to 7.

  The sterilizing water according to the present invention is a sterilizing water containing hypochlorous acid (HCLO), wherein the concentration of the hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7. .

  Moreover, the production method of the sterilizing water according to the present invention, as described in claim 6, by diluting the primary product water obtained by electrolyzing a stock solution obtained by adding sodium chloride and an acid to water, A method for producing sterilized water for producing sterilized water for the purpose of sterilizing periodontal disease bacteria living in the periodontal pocket, wherein the concentration of hypochlorous acid contained in the sterilized water is 201 to 600 ppm, and the pH is 5 After setting the stock solution composition conditions, the electrolysis conditions and the dilution conditions including the addition amount of sodium chloride and the acid so as to be 6 to 7, after preparing the stock solution according to the stock solution composition conditions, according to the electrolysis conditions Electrolyzing the stock solution, and then diluting the primary product water generated by the electrolysis according to the dilution conditions. In the dilution step, the primary product water is diluted through a predetermined discharge pipe. To note As well as, during the injection, the tip position of the discharge pipe is intended to be equal to or less than the water level of the dilution water.

  The method for producing sterilizing water according to the present invention is as described in claim 7, wherein water is passed through a reverse osmosis membrane and only sodium chloride is added to the passing water to obtain a stock solution, and the stock solution is electrolyzed. A method for producing sterilized water, which is used as primary product water and dilutes the primary product water to produce sterilized water containing hypochlorous acid (HCLO), and the concentration of hypochlorous acid contained in the sterilized water After setting the stock solution composition conditions including the added amount of sodium chloride, the electrolysis conditions and the dilution conditions so as to be 201 to 600 ppm and pH 5.6 to 7, and preparing a stock solution according to the stock solution composition conditions, Electrolyzing the stock solution according to the electrolysis conditions, and then diluting the primary water produced by electrolysis according to the dilution conditions. In the diluting step, the primary product water is discharged into a predetermined discharge pipe. Poured into dilution water through While, during the injection, the tip position of the discharge pipe is intended to be equal to or less than the water level of the dilution water.

  Further, according to the method for producing sterilizing water according to the present invention, pure water is allowed to stand in the atmosphere for a predetermined period, and only sodium chloride is added to the left standing water to obtain a stock solution. A method for producing sterilized water by decomposing primary produced water and diluting the primary produced water to produce sterilized water containing hypochlorous acid (HCLO), comprising hypochlorous acid contained in the sterilized water The stock solution composition conditions including the added amount of sodium chloride, the electrolysis conditions and the dilution conditions are set so that the acid concentration is 201 to 600 ppm and the pH is 5.6 to 7, and the stock solution is prepared according to the stock solution composition conditions. And then, electrolyzing the stock solution according to the electrolysis conditions, and then diluting the primary product water generated by the electrolysis according to the dilution conditions. In the dilution step, the primary product water is predetermined. Through the discharge pipe Thereby injected into Shakumizu, during injection, the tip position of the discharge pipe is intended to be equal to or less than the water level of the dilution water.

  In the method for producing sterilizing water according to the present invention, the pH of the stock solution is calculated using the solubility of carbon dioxide at the temperature at which the stock solution is prepared and the concentration of carbon dioxide in the atmosphere, and the calculated value is calculated. It is used to set the stock solution composition conditions, the electrolysis conditions, and the dilution conditions.

  Moreover, the production method of the sterilizing water according to the present invention is 400 to 600 ppm instead of the 201 to 600 ppm.

  Moreover, it replaces with said 5.6-7, and the production | generation method of the sterilizing water which concerns on this invention shall be 6.3-6.7.

  Moreover, the production | generation method of the sterilizing water which concerns on this invention shall be 5.6-6.3 instead of said 5.6-7.

The sterilizing water generating device according to the present invention is an apparatus for electrolyzing a stock solution in an electrolytic cell to generate sterilizing water containing hypochlorous acid (HCLO), as described in claim 13.
The discharge pipe is provided with a stock solution tank for storing the stock solution, an electrolytic bath connected to the stock solution tank, a discharge pipe connected to the electrolytic tank, and a dilution water tank storing dilution water. The position of the dilution water tank relative to the tip position of the discharge pipe is relatively positioned so that the tip of the dilution water is equal to or lower than the level of the dilution water stored in the dilution water tank, and inhabits the periodontal pocket. It produces sterilized water for the purpose of sterilizing periodontal disease bacteria.

  Further, the sterilizing water generating device according to the present invention is a sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria that inhabit the periodontal pocket as described in claim 14. A stock solution tank for storing a stock solution in which only sodium chloride is added to the passing water obtained by passing water through a reverse osmosis membrane, and the stock solution is connected to the stock solution tank to electrolyze the stock solution to produce primary product water. Dilution water that dilutes the primary product water that is discharged through the discharge tank that is connected to the electrolysis tank and that is communicated with the electrolytic tank is stored in advance, and the tip of the discharge pipe is the dilution water. And a dilution water tank in which the discharge pipe is relatively positioned so as to be equal to or lower than the water level, the concentration of the hypochlorous acid (HCLO) in the sterilized water is 201 to 600 ppm, and the pH is 5. The sodium chloride is 6-7. Determine the amount of um, are as defined prescribed or dilution conditions operating conditions of the electrolytic cell.

  Further, the sterilizing water generating device according to the present invention is a sterilizing water generating device for generating sterilizing water for the purpose of sterilizing periodontal disease bacteria that inhabit the periodontal pocket as described in claim 15. A stock solution tank for storing a stock solution in which pure water is added to the standing water obtained by leaving pure water in the atmosphere for a predetermined period; and a primary solution that is connected to the stock solution tank and electrolyzed to the stock solution. Dilution water that dilutes the primary product water discharged through an electrolysis tank that generates product water and is connected to the electrolysis tank through a discharge pipe that is communicated with the electrolysis tank is preliminarily stored, and the tip of the discharge pipe is A dilution water tank in which the discharge pipe is relatively positioned so as to be below the level of the dilution water, and the concentration of the hypochlorous acid (HCLO) in the sterilized water is 201 to 600 ppm, pH To be 5.6-7 Determine the amount of sodium chloride, it is as defined prescribed or dilution conditions operating conditions of the electrolytic cell.

  Moreover, the production | generation apparatus of the sterilizing water which concerns on this invention replaces with said 201-600 ppm, and is 400-600 ppm.

  Moreover, the sterilizing water production | generation apparatus which concerns on this invention is replaced with said 5.6-7, and is set to 6.3-6.7.

  Moreover, the sterilizing water production | generation apparatus which concerns on this invention is replaced with said 5.6-7, and is set to 5.6-6.3.

(Invention related to sterilized water)

  The pathogens of periodontitis are mainly anaerobic gram-negative bacilli and spirochetes, but specifically, the gram-negative short bacilli, Porphyromonas gingivalis (hereinafter P. gingivalis), also gram-negative Actinobacillus actinomycetemcomitans (hereinafter referred to as A.actinomycetemcomitans), Prevotella intermedia, Bacteroides forsythus (Bacteroides forsythus) Eikenella corrodens), Gram-negative bacteria Campylobacter rectus, and Spirocheta (Treponema denticola, hereinafter T. denticola).

  It is difficult for the applicant to kill such periodontal disease bacteria while performing laser treatment using an Er: YAG laser that generates a laser with a transpiration function and a wavelength of 2.94 μm and treatment with antibiotics. Research was conducted focusing on whether or not the conventionally known bactericidal power of hypochlorous acid (HCLO) could not be used.

  However, as already mentioned, since the periodontal disease bacteria inhabit deep in the periodontal pocket as subgingival plaque, it contains a known sterilized water containing hypochlorous acid (HCLO). In addition to oxidizing gingival plaque and organic matter in the oral cavity, when injected directly into the periodontal pocket, it is sterilized by oxidizing the organic matter accumulated in the periodontal pocket and other bacteria that live in the periodontal pocket. Power is consumed. In any case, it was found that hypochlorous acid (HCLO) having a sterilizing power could not be fed deep into the periodontal pocket.

  Therefore, the applicant can kill periodontal disease bacteria by increasing the concentration of hypochlorous acid (HCLO) even if the oxidizing power gradually decreases until reaching the depth of the periodontal pocket. In view of this, the viewpoint of R & D was shifted to increasing the concentration of hypochlorous acid (HCLO).

  However, a high concentration of hypochlorous acid water exceeding 200 ppm has not been disclosed at the time of this application.

  That is, in order to measure the concentration of hypochlorous acid (HCLO), for example, there is a residual chlorine meter sold by Organo Co., Ltd. under the trade name “residual chlorine test paper Aqua Check”, but the measurement range is 0 0.1, 0.5, and 1.0 (mg / L), and when the concentration is 1 ppm or more, the concentration cannot be measured. Similarly, “Digital Residual Chlorine Meter HI 95 Series” is 0.00-5.00 mg / L, “Pocket Residual Chlorine Meter (manufactured by Hack)” is 0.02-2.00 mg / L, “Portable Residual Chlorine Meter” "OR-52" is 0.05 to 2.00 mg / L, and "Portable water quality meter WA-1" is 0.05 to 2.00 mg / L, and 5 ppm or more cannot be measured. In addition, HORIBA Advanced Techno Co., Ltd. sold under the product name “Residual chlorine meter CR-200” has a measuring range of 0 to 2.0 mg / L. From MK Scientific, “Residual chlorine meter C The product sold under the trade name “-201 (completely waterproof type)” is 0.01 to 6.0 mg / L, and the upper limit of measurement is mostly 5 to 6 ppm.

  By the way, what is sold under the trade name of “Residual chlorine measuring device RC-7Z” by Tech Jam Co., Ltd. has a measuring range of 10 to 200 mg / L, “Improved residual salt meter (drain type) ) The product sold under the trade name CL-50H is 20 to 200 mg / L, and the "DPD tablet method digital residual chlorine concentration meter" sold by Toko Chemical Laboratory Co., Ltd. under the trade name AQUALYTIC (made in Germany). "The measurement range of high-concentration effective chlorine is 0 to 200 mg / L, but 200 ppm is still the measurement upper limit.

 Furthermore, Bayer Medical Co., Ltd. sells a test paper under the product name “Nissan Aqua Check HC” as a high-concentration measurement test paper, and the “free residual chlorine concentration is 0, 50, 100, 200, 400, 600 mg. / L has a high measurement range ”(http://www.aquachek.net/aq_08b06.html, Internet search on December 14, 2005). In consideration of the measurement of sodium hypochlorite (strong alkalinity) (omitted), chromogen that has little effect on pH is used. ”(Id.) It measures the concentration of (strongly alkaline) and does not measure hypochlorous acid (HCLO).

  In addition, Tsumoto Rika Sangyo Co., Ltd. sells it under the trade name “Simple Water Quality Test Kit Simple Pack” and explains that “residual chlorine 300 ClO300” can be measured in a concentration range of 50 to 300 mg / L. Although it has been made (http://www.tsumoto-rika.co.jp/simple-pack.htm, Internet search on December 16, 2005), the target of measurement is not hypochlorous acid (HCLO), but hypochlorous acid. It is clear from the above trade name that it is a chlorate ion (CLO).

Similarly, Endo Kagaku Co., Ltd. has a product sold under the trade name “Pack Test WAK-ClO (C)”, and can be measured in a concentration range of residual chlorine (high concentration) of 5 to 10,000 mg / L. Although it has been explained (http://www.endokagaku.co.jp/shop/packtest/packtest_kind.html, Internet search on December 16, 2005), the measurement target is hypochlorous acid (HCLO). It is clear from the trade name that it is hypochlorite ion (CLO ⁻ ).

  Thus, when the concentration of hypochlorous acid (HCLO) exceeds 200 ppm, there is no device capable of measuring the concentration at the time of filing, that is, there is no hypochlorous acid water exceeding 200 ppm. It can be said that it is a proof of not being a known substance.

  Above all, as described above, hypochlorous acid water used for killing periodontal disease bacteria that reside in the periodontal pocket is not disclosed in the prior art.

  The reason why the concentration of hypochlorous acid (HCLO) must be increased in the sterilizing water according to the present invention is as follows.

  (a) Even if the oxidizing power is gradually consumed before reaching the deep part of the periodontal pocket, it must retain the bactericidal power enough to kill the periodontal disease bacteria.

  (b) Sterilizing over a long period of time, for example, 60 seconds or more, will produce an overturned result of sending hundreds of millions of periodontal disease bacteria into the body (intravascular). It must be killed within seconds (according to the applicant's clinical trials, the time required for sterilization when using 200 ppm), preferably within 20 seconds (also 300 ppm), more preferably within 10 seconds (also 400 ppm). In addition, the sterilization time clarified by the clinical test is the time for killing all periodontal disease bacteria present on the entire circumference of one tooth, as described in Examples.

  (c) 300-400 kinds of bacteria in the dental plaque in the oral cavity propagate in a parasitic manner while maintaining a certain balance to form a bacterial flora (so). When it is replaced or when a small number of bacteria are abnormally increased, a change in the bacterial flora called a fungal change phenomenon occurs. That is, when a part of periodontal disease bacteria living in the deep periodontal pocket, for example, T. denticola, survive without being sterilized, a fungus substitution phenomenon occurs and T. denticola grows rapidly. In order to prevent such a situation, it is necessary to sterilize all periodontal disease bacteria that live in the periodontal pocket.

  The sterilizing water according to the present invention has a concentration of hypochlorous acid (HCLO) of 201 to 600 ppm and a pH of 5.6 to 7, and is used for sterilization of periodontal disease bacteria that reside in periodontal pockets. In use, the sterilizing water is injected into the periodontal pocket.

  In this way, the sterilizing water gradually loses the bactericidal power due to oxidation of organic matter and other bacterial cells, but retains the oxidizing power to sterilize the periodontal disease bacteria when reaching deep in the periodontal pocket. Therefore, periodontal disease bacteria can be surely killed. Of course, tooth decalcification is also prevented in advance.

  By the way, the reason why the concentration is set to 201 ppm or more is that it is difficult to achieve the above (a) to (c) at a concentration of 200 ppm or less, and that the concentration exceeding 600 ppm is the above (a) to ( This is because the concentration is unnecessary to achieve c).

  Here, when the concentration of hypochlorous acid (HCLO) is set to 300 to 600 ppm, periodontal disease bacteria can be completely sterilized within several seconds, and when it is set to 400 to 600 ppm, it can be completely sterilized instantaneously.

  In addition, when producing the sterilizing water according to the present invention by adding hydrochloric acid or acetic acid, since the stimulating substance generated simultaneously with the production becomes odor and taste and stimulates the patient, the concentration of hypochlorous acid (HCLO) Is preferably 500 ppm or less, and more preferably 400 ppm or less.

  In injecting the sterilizing water according to the present invention into the periodontal pocket, Er: YAG laser irradiation and scaling are performed to previously remove the biofilm existing deep in the periodontal pocket. Incidentally, it has become clear from the applicant's clinical trial that periodontal disease bacteria cannot be killed only by irradiation with an Er: YAG laser.

  In addition, the use of the sterilizing water according to the present invention is not limited to the sterilization of periodontal disease bacteria that inhabit the periodontal pocket, but can be applied to sterilization of any part of the human body and any part. In addition, the application target is not limited to the human body.

  In addition, if the dissolved gas is removed as will be described later, it is possible to prevent an increase in bleeding from the wound due to the foaming phenomenon and to prevent germs from entering the body.

(Invention relating to method and apparatus for producing sterilizing water)

  In producing the sterilizing water according to the present invention, as long as the sterilizing water is injected into the periodontal pocket, maintaining a pH at which the teeth are not demineralized is an absolute condition. The enamel of the permanent tooth is pH 5.5, and ivory Since the quality is decalcified at pH 6.2 and the deciduous teeth are decalcified at pH 6.2, the pH range is limited to pH 5.6 or higher. In addition, assuming a case where dentin is exposed without being covered with enamel, the pH range is limited to pH 6.3 or more.

Chlorine, on the other hand, is a chemical substance that changes the form of chlorine gas, hypochlorous acid (HCLO), hypochlorite ion (CLO ⁻ ) and its form depending on the pH environment, and chlorine gas is widely toxic. As is known, when dilution is performed to adjust the concentration, the pH varies and the form of chlorine also changes.

  Specifically, in order to contain chlorine in a sufficient ratio in an aqueous solution in the form of hypochlorous acid (HCLO), pH 2.2 to pH 7 (as a guideline, hypochlorous acid (HCLO) in the percentage of available chlorine) Is about 80% or more), desirably pH 2.8 to pH 6.7 (hypochlorous acid (HCLO) is about 90% or more in the percentage of available chlorine).

  Therefore, when producing highly concentrated hypochlorous acid water as sterilizing water, the pH of the sterilizing water is 5.6 or more and 7 or less (6.3 or more and 7 or less), preferably 5.6 or more and 6.7 or less ( 6.3 to 6.7), and the sterilized water after dilution must have a desired high concentration as a matter of course. In other words, a very difficult problem has arisen in that the pH after dilution must be accurately controlled and the concentration variation of hypochlorous acid (HCLO) due to dilution must be taken into account at the same time.

  On the other hand, known methods for using sodium chloride (NaCL), acid and water as a stock solution and simply electrolyzing the stock solution are hand disinfection, fruit / vegetable disinfection, food production line disinfection, disinfection of bathrooms, etc. Since sterilization of pool water, bleach, disinfection of waste water after sewage treatment, etc. are used, strict pH control is not necessary. Rather, the pH may be in a range that is not problematic for hygiene, for example, about 4 to 6, and a large amount of sterilizing water is required.

Therefore, in the known method described above, during electrolysis, the inside of the electrolytic cell is adjusted to a strongly acidic side (for example, about pH 1), and the water pipe is joined to the discharge pipe connected to the electrolytic cell, thereby allowing electrolysis. The strongly acidic water that came out of the tank was diluted about 10 ³ to 10 ⁵ times to obtain a large amount of hypochlorous acid water of several tens of ppm.

  In such a method, although the pH of the generated hypochlorous acid water is in the range of 4 to 6 described above, it is diluted in a large amount, and therefore hypochlorous acid water is generated at a pH as the target value. However, the concentration of hypochlorous acid is naturally as low as several tens of ppm.

  As described above, a method for producing sterilizing water having a hypochlorous acid (HCLO) concentration of 201 to 600 ppm and a pH of 5.6 to 7 or 6.3 to 7 has not been clarified in the prior art.

  In addition, it is essentially difficult to produce sterilized water so that the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm, the pH is 5.6 to 7, or the pH is 6.3 to 7. There is a good reason.

  That is, as long as high-concentration hypochlorous acid water is generated, it is necessary to lower the dilution rate. However, when the dilution rate is small, the water supply speed (water supply amount) by the dilution water pump becomes small and the pulsating flow occurs. It is difficult to produce homogeneous hypochlorous acid water.

  In the past, strong acidic water having a pH of about 1 was diluted in a large amount in the pipe, so there is little risk of chlorine gas being generated, and even if chlorine gas is temporarily generated and volatilized, it is in the pipe, so There was no need to worry about leakage into the pipe. However, when a trouble occurs in which the pH shifts to the acidic side and chlorine gas is generated due to the fact that the product is not as designed, it is necessary to take some safety measures.

  It is extremely difficult to set up the stock solution composition and the operating conditions of the electrolytic cell, and it is realistic in terms of stability and accuracy that the dilution itself is not performed, that is, the hypochlorous acid water is directly generated by electrolysis. Lack.

  Accordingly, the present applicant has obtained the following new knowledge regarding a method for producing sterilizing water that can be produced homogeneously and safely while satisfying strict requirements regarding concentration and pH.

  That is, in the method for producing sterilizing water according to the present invention, when diluting primary product water obtained by electrolyzing a stock solution obtained by adding sodium chloride and an acid to water, Parameters related to the stock solution such as the amount of sodium chloride and acid added (hereinafter, stock solution composition) so that the concentration of hypochlorous acid contained in the sterilized water is 201 to 600 ppm and the pH is 5.6 to 7 or 6.3 to 7. Conditions), parameters relating to electrolysis (hereinafter referred to as electrolysis conditions) such as voltage value and current value, and parameters relating to dilution (hereinafter referred to as dilution conditions) such as dilution factor and type of dilution water.

  Since the acid functions as a pH adjuster, any acid such as hydrochloric acid or acetic acid can be used.

  Moreover, the water which is a component of the stock solution can be well water, tap water, etc., and it is not necessary to use pure water. However, it goes without saying that it is better to use pure water that does not contain calcium ions, magnesium ions, etc., in order to prevent electrode damage in the electrolytic cell and reduction in electrode reaction.

  The same applies to the dilution water, and well water, tap water, pure water, or the like can be used. In addition, pH of dilution water sets suitably so that pH of produced | generated sterilization water may become the range mentioned above.

  After preparing the stock solution according to the set stock solution composition conditions, this is stored in the stock solution tank.

  Next, the stock solution is put in an electrolytic cell according to electrolysis conditions, and the stock solution is electrolyzed.

  Next, the primary generated water generated in the electrolytic cell is injected into diluted water stored in advance in a diluted water tank through a discharge pipe connected to the electrolytic cell.

  Here, the installation position of the dilution water tank is relatively positioned so that the tip position of the discharge pipe is equal to or lower than the level of the dilution water stored in the dilution water tank.

  Therefore, if the primary product water is injected into the dilution water through the discharge pipe, it is injected in a non-contact state with air.

  In this way, even if the mixing ratio of the stock solution and the operating conditions of the electrolytic cell are different from the design values, and chlorine gas is generated due to this, the chlorine gas is diluted with a neutral pH environment. In water, its form changes to hypochlorous acid (HCLO), and there is no fear of volatilization in the air as chlorine gas.

  Here, the dilution water is measured in advance so that the primary product water is diluted at the dilution rate set in the dilution condition, and then stored in the dilution water tank. When the next generated water is injected into the dilution water tank, the injection operation is finished.

  By doing so, hypochlorous acid water having a designed concentration and pH can be produced safely and homogeneously.

  The dilution rate may be determined according to the required concentration of hypochlorous acid (HCLO). For example, if hypochlorous acid water having a concentration of 400 ppm is required, the stock solution composition conditions and the electrolysis conditions are appropriately set so that the concentration of hypochlorous acid (HCLO) in the primary product water is 4000 ppm. The dilution factor may be set to 10.

(Invention relating to sterilized water and its production method-no addition of hydrochloric acid or acetic acid)

  According to the method for producing sterilized water described above, sterilized water having a hypochlorous acid (HCLO) concentration of 201 to 600 ppm and a pH of 5.6 to 7 or 6.3 to 7 can be produced. According to this, it is possible to sterilize the periodontal disease bacteria that inhabit the periodontal pocket in a few seconds per tooth.

  However, since it is necessary to add hydrochloric acid and acetic acid to the undiluted solution in the method for producing such sterilizing water, pH control becomes difficult, and in combination with components contained in water from the beginning, hypochlorous acid (HCLO) In addition to this, various substances, especially stimulating substances that stimulate the senses of taste and smell, are generated, causing discomfort to the patient.

  Therefore, when using the sterilized water produced by the production method described above in the oral cavity, it is desirable that the upper limit is 500 ppm, preferably 400 ppm.

  Even at such concentrations, periodontopathic bacteria inhabiting the periodontal pocket can be sterilized within a few seconds per tooth, but the patient's discomfort regarding odor and taste cannot be further reduced, or pH control is included As a result of the applicant's further research focusing on the possibility of further simplifying the sterilizing water generation process, the inventors succeeded in developing an innovative sterilizing water manufacturing method. According to such a method for producing sterilizing water, the addition of hydrochloric acid and acetic acid, which are considered essential for the production of hypochlorous acid water, is unnecessary, and the generation of stimulating substances is also prevented accordingly. Even if the concentration of hypochlorous acid (HCLO) is increased to 600 ppm, the patient does not feel uncomfortable with respect to odor and taste.

  In the method for producing sterilizing water according to claims 7 and 8, the stock solution composition conditions, electrolysis conditions and dilution conditions are set in substantially the same procedure as in the invention according to claim 6, but the invention according to claim 7 Then, water is passed through a reverse osmosis membrane, and only sodium chloride is added to the passing water to prepare a stock solution. In the invention according to claim 8, pure water is left in the atmosphere for a predetermined period, The stock solution is prepared by adding only acid, and no acid such as hydrochloric acid or acetic acid is added. The stock solution composition condition is mainly determined by the amount of sodium chloride added.

  Since the reverse osmosis membrane has a pore size of 1 / 1,000,000 mm, it allows water molecules that are slightly smaller than it to pass through, but larger molecules are not allowed to pass through it, and ions are electrically passed through. Since there is also a function to eliminate, even a substance smaller than 1 / 1,000,000 mm, such as sodium ion, is almost completely removed like other ions.

  Such a reverse osmosis membrane was originally studied as a means for desalinating seawater, but is now widely used for the production of industrial pure water such as semiconductor cleaning and ultrapure water.

  However, even with such a reverse osmosis membrane having a high water purification function, it is difficult to prevent the passage of gas, and gases such as oxygen and carbon dioxide dissolved in water pass through the reverse osmosis membrane.

  Therefore, in processes where pH requirements are severe, it is not uncommon for degassing to remove dissolved gas before applying reverse osmosis. In addition, carbon dioxide in the atmosphere dissolves in pure water just generated in a short time and easily.

  The present applicant focused on whether such properties relating to reverse osmosis membranes and pure water could be used in reverse, and produced pure water by applying tap water to the reverse osmosis membrane, and repeated the experiment.

  As a result, the pH of tap water was about 6 to 8 and the pH of the water that passed through the reverse osmosis membrane was about 5 to 6 although there was considerable variation nationwide.

  Because tap water contains various substances including minerals, the pH of tap water itself varies, but ions that contribute to the pH are almost completely removed by the reverse osmosis membrane. It is thought that the reason is that only the contribution of pH due to the above has become apparent.

  If this property is utilized, the applicant will further study that it is possible to produce sterilized water containing high concentration of hypochlorous acid (HCLO) without adding acid such as hydrochloric acid or acetic acid. As a result of the advancement, the above-described invention has been achieved.

  That is, the pH of water that has passed through a reverse osmosis membrane or water that has been left pure in the atmosphere for a certain period of time depends on carbon dioxide in the atmosphere, and it is a weakly acidic undiluted solution without the need to add acid such as hydrochloric acid or acetic acid. Can be obtained safely in a state in which the pH is generally determined, and since the pH value is known, electrolysis conditions and dilution conditions can be easily set.

  Above all, the dissolved substances contained in tap water and well water are removed in advance with a reverse osmosis membrane, or are removed from the beginning because they are pure water, and hydrochloric acid and acetic acid are not added at all. As a result, even if the concentration of hypochlorous acid (HCLO) is 500 ppm to 600 ppm, it does not cause any discomfort to the patient and can be performed in a short time of several seconds per tooth. It has an epoch-making action effect that periodontal disease bacteria can be completely sterilized.

  In addition, since the production | generation procedure of the sterilization water after electrolysis is the same as that of the invention which concerns on Claim 6, the detailed description is abbreviate | omitted here.

(Degassing)

  The sterilized water produced by each of the production methods described above may be used as the sterilized water according to the present invention, but the dissolved gas is removed from the water in which the primary produced water is injected into the dilution water (hereinafter, the secondary produced water). If this is used as sterilizing water, the foaming phenomenon in the periodontal pocket can be prevented, and the situation in which periodontal disease bacteria are sent into the body (in the blood vessel) can be more reliably prevented.

  That is, when the stock solution is electrolyzed, oxygen and hydrogen are naturally generated in the electrolytic cell. And these remain in water as dissolved gas. In particular, oxygen tends to remain as dissolved oxygen.

  In this case, there is no problem if the concentration of dissolved gas is low, but when the concentration of dissolved gas increases due to the electrolysis operating conditions, etc., when sterilizing water (secondary product water) is injected into the periodontal pocket, In the periodontal pocket, dissolved oxygen becomes a gas to cause a foaming phenomenon, which stimulates capillaries in the periodontal pocket to increase bleeding.

  In such a situation, there is a concern that some periodontal bacteria are sent into the body (intravascular) while periodontal bacteria are sterilized.

  However, if the tertiary generated water obtained by removing dissolved gas from the secondary generated water is used as sterilizing water, there is no concern that a foaming phenomenon will occur when injected into the periodontal pocket.

  In order to remove the dissolved gas, the tertiary product water tank that stores the tertiary product water as sterilizing water is connected to the dilution water tank, and the dissolved gas is removed between the tertiary product water tank and the dilution water tank. What is necessary is just to interpose a means.

  As the dissolved gas removal means, for example, a hollow fiber membrane deaeration module sold by Dainippon Ink & Chemicals, Inc. can be used. If such a hollow fiber membrane deaeration module is used, 1 ppb of dissolved oxygen is used. It is possible to deaerate to the level, and the foaming phenomenon in the periodontal pocket can be surely prevented.

Schematic which showed the production | generation apparatus of the sterilization water which concerns on 1st Embodiment. Schematic which showed the production | generation apparatus of the sterilization water which concerns on a modification. The graph which showed the effect of sterilization water concerning this embodiment. The graph which similarly showed the effect of the sterilizing water which concerns on this embodiment. The figure which showed the difference of the effect by the sterilization method (before disinfection). The figure which showed the difference of the effect by the sterilization method (after scaling). The figure which showed the difference of the effect by the sterilization method (after laser treatment). The figure which showed the difference of the effect by the sterilization method (high concentration hypochlorous acid water). The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. The figure which showed the mode before a treatment at the time of using the disinfecting water (high concentration hypochlorous acid water) which concerns on this embodiment for a severe periodontal disease patient. The figure which similarly showed the state after treatment. Schematic which showed the production | generation apparatus of the sterilization water which concerns on 2nd Embodiment. Schematic which showed the production | generation apparatus of the sterilization water which concerns on a modification. The figure which showed the mode after treatment when the density | concentration of hypochlorous acid (HCLO) is 200 ppm and the sterilization water of pH 6.3-6.7 is used. The figure which showed the mode after the treatment at the time of using the same disinfection water. The figure which showed the mode after the treatment at the time of using the same disinfection water. The figure which showed the mode after the treatment at the time of using the same disinfection water. The figure which showed the mode after the treatment at the time of using the same disinfection water. The figure which showed the mode after the treatment at the time of using the same disinfection water. The figure which showed the mode after the treatment at the time of using the same disinfection water. The figure which showed the mode after treatment when the density | concentration of hypochlorous acid (HCLO) is 500 ppm and the sterilization water of pH 6.3-6.7 is used. The figure which showed the mode after the treatment at the time of using the same disinfection water.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,21 Production | generation apparatus 2,22 Sterilized water 2,22 Stock solution 3 Stock solution tank 5 Electrolysis tank 6 Discharge pipe 7,27 Dilution water 8 Dilution water tank 9 Water level sensor 11 Deaeration module 14 Tertiary production water tank

  Embodiments of sterilizing water, a method for producing the same, and a producing apparatus according to the present invention will be described below with reference to the accompanying drawings. Note that components that are substantially the same as those of the prior art are assigned the same reference numerals, and descriptions thereof are omitted.

(First embodiment)

  The sterilizing water according to the present embodiment has a concentration of hypochlorous acid (HCLO) of 300 to 400 ppm, a pH of 6.3 to 6.7, and is used for sterilization of periodontal disease bacteria that reside in periodontal pockets. It is what.

  Here, the reason for setting it to 300 ppm or more is not only to retain the oxidizing power to sterilize the periodontal disease bacteria when reaching deep in the periodontal pocket, but also to completely sterilize the periodontal disease bacteria within a few seconds. The reason why it is 400 ppm or less is to alleviate the stimulus given to the oral cavity.

  In order to treat periodontal disease using the sterilizing water according to this embodiment, first, the biofilm existing deep in the periodontal pocket is removed by performing irradiation and scaling of an Er: YAG laser.

  Next, for example, an irrigation chip (cleaning chip) is attached to an ultrasonic scaler, and the tip of the irrigation chip is inserted into a periodontal pocket to inject sterilizing water according to the present embodiment. Here, sterilizing water can be injected while removing the biofilm with an ultrasonic scaler.

  In this way, the sterilizing water according to the present embodiment has a periodontopathic fungus when it reaches deep in the periodontal pocket while gradually sterilizing the bactericidal power due to oxidation of organic matter and other bacterial cells in the periodontal pocket. It retains the oxidative power to sterilize and can kill periodontal bacteria. Of course, tooth decalcification can also be prevented beforehand.

  In addition, according to the sterilizing water according to the present embodiment, since the concentration of hypochlorous acid (HCLO) is adjusted to 300 to 400 ppm, the periodontal disease bacteria that live deep in the periodontal pocket are within a few seconds (400 ppm). It can be completely sterilized instantaneously at nearby concentrations.

  Incidentally, it has hitherto been said that it is difficult to kill periodontal disease bacteria in the periodontal pocket. In other words, Treponema denticola (Treponema denticola), which is classified as a spirochete, has been researched since the time of Dr. Hideyo Noguchi. It has been elucidated that no antibodies are produced. That is, T. denticola has an immunosuppressive factor, and this immunosuppressive factor inhibits the antigen recognition function of macrophages. Therefore, even if T. denticola is present, antibodies against T. denticola are not generated. Not only that, T. denticola's immunosuppressive factor has the effect of suppressing the immune response against other periodontal pathogens, and as a result, T. denticola, together with other periodontal pathogens, in the periodontal pocket. Increases rapidly.

  In that sense, the sterilizing water according to the present embodiment that can instantly sterilize the periodontal disease bacteria in the periodontal pocket is truly epoch-making, and as described in the examples described later, its action effect is a remarkable word. run out.

  In addition, periodontal disease bacteria that were said to be difficult to kill can be completely sterilized, so naturally supragingival plaque as well as other subgingival plaques residing in the periodontal pocket are naturally sterilized. can do.

  For example, Streptococcus sanguis, which is the most common dental plaque on the gingival margin and causes subacute bacterial endocarditis, and causes of bacterial endocarditis by inhabiting various parts of the oral cavity The fungus Streptococcus mitis can also be killed.

  Next, the production | generation apparatus which produces | generates the sterilization water based on this embodiment is shown in FIG.

  As can be seen from the figure, the sterilizing water generator 1 according to this embodiment includes a stock solution tank 3 for storing a stock solution 2, a stroke pump 4 connected to the stock solution tank, and a stroke pump connected to the stroke pump. A water level sensor as an electrolyzer 5, a discharge pipe 6 connected to the electrolyzer, a diluting water tank 8 in which diluting water 7 is stored, and a water level measuring means for measuring the water level in the diluting water tank 9, and the position where the dilution water tank 8 is installed relative to the tip position of the discharge pipe 6 is relatively positioned so that the tip of the discharge pipe 6 is equal to or lower than the level of the dilution water 7 stored in the dilution water tank 8. It is.

  The stock solution 2 can be composed of, for example, sodium chloride (NaCL), hydrochloric acid (HCL), and water. However, since hydrochloric acid functions as a pH adjuster, any acid such as acetic acid can be used.

  As the electrolytic cell 5, for example, an electrolytic cell used in an electrolysis neutral water generator sold by Sakai Engineering Co., Ltd. under the trade name “Epios Eco” can be used.

  What is necessary is just to select the water level sensor 9 suitably from an ultrasonic sensor, an electrode type sensor, etc., for example.

  The dilution water 7 can be well water, tap water, pure water or any other water, but the pH is appropriately selected so that the pH of the produced sterilizing water is in the above-described range.

  The production apparatus 1 according to the present embodiment further includes a deaeration module 11 in which the water injection side is communicated with the secondary production water 10 obtained by diluting the primary production water with the dilution water 7 in the dilution water tank 8. The deaeration module is adapted to remove dissolved oxygen in the secondary product water 10 by reducing the pressure by the vacuum pump 12, and sterilize the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 10. As a third generation water tank 14 to be stored.

  As the degassing module 11, for example, a hollow fiber membrane degassing module sold by Dainippon Ink & Chemicals, Inc. can be used. In particular, a degassing module for chemical liquid in which polytetrafluoroethylene hollow fiber is used for the degassing membrane and all the liquid contact parts are fluororesin is desirable.

  It should be noted that the tubes used in the generating device 1 or the electromagnetic valve provided as necessary may be deteriorated by oxidation with high-concentration hypochlorous acid (HCLO), so that it is desirable to form with fluorine.

  In order to generate the sterilizing water 13 using the sterilizing water generator 1 according to the present embodiment, first, the concentration of hypochlorous acid (HCLO) in the secondary generated water is 300 to 400 ppm and the pH is 6. The composition of undiluted solution 2, its blending ratio, operating conditions (for example, voltage value and current value) at the time of electrolysis and dilution conditions (dilution ratio and pH of diluted water) are determined and blended so as to be 3 to 6.7. The stock solution 2 is stored in the stock solution tank 3.

  Next, while the stock solution 2 is sent to the electrolytic cell 5 by the stroke pump 4, the electrolytic cell 5 is operated under a predetermined operating condition, and the stock solution 2 is electrolyzed.

  Next, the primary produced water produced | generated in the electrolytic vessel 5 is inject | poured in the diluting water 7 previously stored by the diluting water tank 8 through the discharge pipe 6 connected to this electrolytic vessel.

  Here, the installation position of the dilution water tank 8 is relatively positioned so that the front end position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 7 stored in the dilution water tank 8.

  Therefore, if the primary product water is injected into the dilution water 7 through the discharge pipe 6, it is injected in a non-contact state with air.

  In this case, even if the mixing ratio of the stock solution 2 and the operating conditions of the electrolytic cell 5 are different from the design values, and chlorine gas is generated due to this, the chlorine environment has a neutral pH environment. In the near dilution water 7, the form is changed to hypochlorous acid (HCLO), and there is no fear of volatilizing in the air as chlorine gas.

  The amount of dilution water 7 is measured in advance so that the primary product water is diluted at the dilution rate, and the measured water level increase value obtained by the water level sensor 9 corresponds to the target water level increase value corresponding to the dilution rate. , The injection of the primary product water through the discharge pipe 6 is terminated.

  If it does in this way, the secondary production | generation water 10 of the density | concentration and pH as designed can be produced | generated.

  Next, by passing the secondary product water 10 through the deaeration module 11, the tertiary product water from which dissolved gas, particularly dissolved oxygen is removed, is generated and stored in the tertiary product water tank 14 as sterilizing water 13. To do.

  As described above, according to the sterilizing water generating method and generating device 1 according to the present embodiment, the dissolved gas is removed from the secondary generated water 10 to generate the tertiary generated water 13, which is referred to as sterilizing water. Therefore, it is possible to prevent the foaming phenomenon in the periodontal pocket and prevent the periodontal disease bacteria from being sent into the body (intravascular).

In the present embodiment, the dissolved gas in the secondary product water 10 is removed using the degassing module 11, but there is a concern that a foaming phenomenon may occur due to the low concentration of the dissolved gas in the secondary product water 10. If not, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 10 is sterilized water.
FIG. 2 is a diagram showing the generation device 1a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generation device 1.

  In the present embodiment, the water level sensor 9 is used as the water level measuring means. Instead, for example, a scale is attached to the dilution water tank 8 in advance, and the water level is measured using this scale as a guide. It doesn't matter. Furthermore, the water level measuring means may be omitted and the measurement may be performed separately.

Moreover, although this embodiment demonstrated the example which produces | generates sterilizing water so that pH might be 6.3-6.7 or 6.3-7, it is so that pH may be 5.6-6.3. The same procedure can be followed when producing sterilized water.
Further, in the present embodiment, the sterilizing water, the generation method and the generation apparatus for the purpose of sterilization of periodontal disease bacteria that inhabit in the periodontal pocket have been described, but the sterilizing water according to the present invention is hypochlorous acid. Since the concentration of (HCLO) is 201 to 500 ppm and the pH is 6.3 to 7, the bactericidal power is inherently strong and the pH is near neutral. I can't.

  Therefore, the use of the sterilizing water according to the present invention is not limited to the sterilization of periodontal disease bacteria that inhabit the periodontal pocket, but can be applied to sterilization of any part of the human body and any part. In addition, the application target is not limited to the human body.

  In particular, if the dissolved gas is removed, it is possible to prevent bleeding from the wound due to the foaming phenomenon and prevent germs from entering the body. It is a very useful tool.

  In addition, it cannot be overemphasized that the production | generation method and production | generation apparatus of this embodiment can apply the production | generation method and production | generation apparatus of this sterilization water as they are.

(Clinical trial using sterilized water)
A clinical trial was conducted to examine the relationship between the concentration and the bactericidal level in T. denticola.

  The test was performed using an Er: YAG laser (repetition rate: 30 pps, laser beam output energy: 60 mj / pulse) while removing all dental biofilms while injecting 20 ppm of low-concentration hypochlorous acid water. An irrigation chip was attached to the sonic scaler, and highly concentrated hypochlorous acid water was injected.

  The high-concentration hypochlorous acid water had a pH of 6.5 and a concentration of 200, 300, 400 ppm. And the case where 20 ppm of low concentration hypochlorous acid water was used was made before treatment, and the case where high concentration hypochlorous acid water was used was made after treatment. Here, the state of periodontal disease bacteria before and after treatment was determined by inserting a probe into the bottom of the periodontal pocket without touching saliva, collecting plaque and blood adhering to the root surface, and using this slide glass After suspending in physiological saline, the sample was covered with a cover glass and observed with a high-resolution phase contrast microscope of 3600 times.

  FIG. 3 is a graph showing the tendency of sterilization in 10 seconds, 20 seconds, and 30 seconds, respectively. The sterilization level 0 is a level where there is almost no change in the number of bacteria, and the sterilization level 1 has a tendency to decrease in the number of bacteria. Level and sterilization level 2 indicate levels at which complete sterilization was achieved.

  As can be seen from the figure, when the time of injecting high concentration hypochlorous acid water into the periodontal pocket is, for example, 10 seconds, the sterilization level is almost 0 when the concentration of hypochlorous acid (HCLO) is less than 300 ppm. However, at 400 ppm, the sterilization level was 2, indicating that complete sterilization was possible. Considering this graph from another viewpoint, for example, when the concentration is 200 ppm, complete disinfection (sterilization level 2) is 40 seconds, when the concentration is 300 ppm, 20 seconds, and when the concentration is 400 ppm, complete is 10 seconds. It can be seen that sterilization is possible.

  Here, the time for injecting high-concentration hypochlorous acid water into the periodontal pocket means the time for injecting per tooth, in other words, over the entire circumference of one tooth.

  FIG. 4 is a graph showing the relationship between the concentration of hypochlorous acid (HCLO) and the complete sterilization time. As can be seen from FIG. 4, the concentration is 200 seconds at 200 ppm, 20 seconds at 300 ppm, and 10 seconds at 400 ppm. It was found that complete sterilization was possible. As with the above definition, the complete sterilization time is the hypochlorite necessary to sterilize all periodontal bacteria in the periodontal pocket distributed per tooth, in other words, around the entire circumference of one tooth. It means the time of water injection of acid water.

  By the way, it doesn't make any sense to complete sterilization over a long time. This is because, for example, performing sterilization over 60 seconds or more will send hundreds of millions of periodontal disease bacteria into the body (intravascular).

(Bactericidal effect due to different treatment methods)
The bactericidal effect by the difference of the treatment method was verified.

  5 shows the state before sterilization, FIG. 6 shows the state after scaling, FIG. 7 shows the state after the laser treatment (30 pps, 60 mj / pulse), and FIG. 8 shows the state after the treatment with high concentration hypochlorous acid water (400 ppm). A still image is cut out from a moving image photographed through a high-resolution phase-contrast microscope (3600 times). The scaling and laser treatment were performed while injecting 20 ppm of low concentration hypochlorous acid water. Further, the high-concentration hypochlorous acid water was injected by attaching an irrigation chip to an ultrasonic scaler as in Example 2.

  As can be seen from these figures, in scaling (FIG. 6) and laser treatment (FIG. 7) using low-concentration hypochlorite water of 20 ppm, periodontal disease bacteria such as spirochetes are not eradicated (FIG. 5). The spirochete, a spiral bacterium, is actively moving around on the video. On the other hand, when a treatment with 400 ppm high-concentration hypochlorous acid water was performed (FIG. 8), it can be seen that most bacteria, including periodontal disease bacteria, were killed.

(Clinical trial results)
A clinical trial was conducted on patients with severe periodontal disease using high concentration hypochlorous acid water at 400 ppm and pH 6.5.

  FIG. 9 shows the state before the treatment, and FIG. 10 shows the removal of the biofilm by laser treatment. As in Examples 2 and 3, the ultrasonic scaler is attached with an irrigation chip, and high-concentration hypochlorous acid water is added to the periodontal pocket. FIG. 2 shows the state after injection for 10 seconds (after treatment), and each is a still image cut out from a moving image taken through a high-resolution phase-contrast microscope (3600 times).

  FIGS. 11 to 38 similarly show the states before and after treatment for another severe patient.

  As can be seen in these figures, P. gingivalis (gram-negative bacilli) and T. denticola (spirocheta), which were in large numbers before treatment, are completely sterilized with high-concentration hypochlorous acid water. I understand that.

(Second Embodiment)

  Next, a second embodiment will be described. Note that components that are substantially the same as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.

  The sterilizing water according to the present embodiment has a concentration of hypochlorous acid (HCLO) of 300 to 600 ppm, a pH of 6.3 to 6.7, and is used for sterilization of periodontal disease bacteria that reside in periodontal pockets. It is what.

  Here, the reason for setting it to 300 ppm or more is not only to retain the oxidizing power to sterilize the periodontal disease bacteria when reaching deep in the periodontal pocket, but also to completely sterilize the periodontal disease bacteria within a few seconds. The reason why the concentration is 600 ppm or less is that it is not necessary to increase the concentration to sterilize the periodontal disease bacteria in the periodontal pocket.

  In order to treat periodontal disease using the sterilized water according to the present embodiment, as in the first embodiment, first, by performing irradiation and scaling of Er: YAG laser, biofilm existing deep in the periodontal pocket Next, for example, an irrigation chip is mounted on an ultrasonic scaler, the tip of the irrigation chip is inserted into a periodontal pocket, and sterilizing water according to this embodiment is injected. Here, sterilizing water can be injected while removing the biofilm with an ultrasonic scaler.

  In this way, the sterilizing water according to the present embodiment has a periodontopathic fungus when it reaches deep in the periodontal pocket while gradually sterilizing the bactericidal power due to oxidation of organic matter and other bacteria in the periodontal pocket. It retains the oxidative power to sterilize and can kill periodontal bacteria. Of course, tooth decalcification can also be prevented beforehand.

  In addition, according to the sterilizing water according to the present embodiment, since the concentration of hypochlorous acid (HCLO) is adjusted to 300 to 600 ppm, the periodontal disease bacteria that live deep in the periodontal pocket are within a few seconds (400 This embodiment can be instantly sterilized in the sense that it can be completely sterilized at a concentration of up to ˜600 ppm and can be completely eradicated from periodontal disease bacteria that were conventionally said to be unable to be killed. The sterilizing water according to can be said to be innovative as in the first embodiment.

  Next, the production | generation apparatus which produces | generates sterilizing water based on this embodiment is shown in FIG.

  As can be seen from the figure, the sterilizing water generator 21 according to the present embodiment includes a stock solution tank 3 that stores a stock solution 22, a stroke pump 4 that is connected to the stock solution tank, and a stroke pump that is connected to the stroke pump. And a diluting water tank 8 in which dilution water 27 is stored, and a diluting solution in which the tip of the discharge pipe 6 is stored in the diluting water tank 8. The installation position of the dilution water tank 8 is relatively positioned with respect to the tip position of the discharge pipe 6 so as to be equal to or lower than the water level of the water 27.

  In the stock solution 22, only sodium chloride (NaCL) is added to the passing water obtained by passing tap water through a reverse osmosis membrane, and no acid such as hydrochloric acid or acetic acid is added.

  As the electrolytic cell 5, for example, an electrolytic cell used in an electrolysis neutral water generator sold by Sakai Engineering Co., Ltd. under the trade name “Epios Eco” can be used.

  The dilution water 27 can be well water, tap water, pure water, or any other water, but the pH is appropriately selected so that the pH of the produced sterilizing water is in the above-described range.

  The generation apparatus 21 according to the present embodiment further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 30 obtained by diluting the primary generation water with the dilution water 27 in the dilution water tank 8. The deaeration module is adapted to remove dissolved oxygen in the secondary product water 30 by decompression by the vacuum pump 12, and sterilize the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 30. As a third generation water tank 14 to be stored.

  Note that the tubes used in the generating device 21 or the electromagnetic valve provided as necessary may be deteriorated by oxidation with high-concentration hypochlorous acid (HCLO), so that it is desirable to form with fluorine.

  In order to produce the sterilized water 33 using the sterilized water generator 21 according to the present embodiment, first, water is passed through a reverse osmosis membrane, and only sodium chloride is added to the passing water to produce a stock solution 22. To do.

  Since the water purifier provided with the reverse osmosis membrane is commercially available from several manufacturers, the water purifier may be appropriately selected and employed.

  The water may have any properties, but water that has been purified to some extent is desirable in order to reduce the burden on the reverse osmosis membrane and the water purifier using it, or to reduce the amount of waste water as much as possible. In terms of producing sterilized water more safely, it is desirable to use water having a pH close to neutral. For example, ground water, tap water, or commercially available mineral water (commercial water) can be used.

  If such water is passed through the reverse osmosis membrane, the pH of the passing water is approximately 5-6.

  This is because even if various substances including minerals are contained in water, ions that contribute to pH are almost completely removed by the reverse osmosis membrane, and only dissolved carbon dioxide passes through. Combined with carbon dioxide dissolved from the atmosphere,

H ₂ CO ₃ → H ⁺ + HCO ₃ ⁻
It is because it dissociates like this.

  Next, thorium chloride is added to the water that has passed through the reverse osmosis membrane to form a stock solution 22, which is stored in the stock solution tank 3, and the stock solution 22 is sent to the electrolytic cell 5 by the stroke pump 4 under the specified operating conditions. The electrolytic cell 5 is operated to electrolyze the stock solution 22.

  Here, the addition amount of sodium chloride, which is a raw solution composition condition, and electrolysis conditions are as follows: the primary product water produced by electrolysis is diluted, and then the concentration of hypochlorous acid (HCLO) is 300 to 600 ppm, pH Is appropriately set so that secondary product water of 6.3 to 6.7 is generated.

  On the other hand, the dilution water tank 8 is filled with an amount of dilution water 27 corresponding to the dilution factor.

  Next, the primary produced water produced | generated in the electrolytic vessel 5 is inject | poured in the dilution water 27 previously stored by the dilution water tank 8 through the discharge pipe 6 connected to this electrolytic vessel.

  Here, the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 27 stored in the dilution water tank 8.

  Therefore, if the primary product water is injected into the dilution water 27 through the discharge pipe 6, it is injected in a non-contact state with air.

  In this way, even if the amount of sodium chloride added and the operating conditions of the electrolytic cell 5 are different from the design values, and chlorine gas is generated due to this, the chlorine environment has a neutral pH environment. In the near dilution water 27, the form is changed to hypochlorous acid (HCLO), and there is no fear of volatilizing in the air as chlorine gas.

  Next, by passing the secondary product water 30 through the degassing module 11, the tertiary product water from which dissolved gas, particularly dissolved oxygen is removed, is generated and stored in the tertiary product water tank 14 as sterilizing water 33. To do.

  As described above, according to the method and apparatus 21 for generating sterilizing water according to the present embodiment, the pH of water that has passed through the reverse osmosis membrane depends on carbon dioxide in the atmosphere and is generally 5 to 6. .

  Therefore, it is possible to safely obtain a weakly acidic stock solution in a state where the pH has been determined, without adding an acid such as hydrochloric acid or acetic acid, and because the pH value is known, electrolysis conditions and dilution conditions can be obtained. Can also be set easily.

  Above all, dissolved substances contained in tap water and well water are removed in advance with a reverse osmosis membrane, and no hydrochloric acid or acetic acid is added at all. Even if the concentration of hypochlorous acid (HCLO) is 500 ppm to 600 ppm, the periodontal disease bacteria can be completely sterilized in a short time of several seconds per tooth without causing any discomfort to the patient. There are periodical effects.

  Moreover, according to the production | generation method and the production | generation apparatus 21 which concern on this embodiment, since dissolved gas was removed from the secondary production | generation water 30 and the tertiary production | generation water 33 was produced | generated and this was used as sterilization water, teeth It is possible to prevent the foaming phenomenon in the peripheral pocket and prevent the periodontal disease bacteria from being sent into the body (in the blood vessel).

  In the present embodiment, water is passed through a reverse osmosis membrane, and only sodium chloride is added to the passing water to prepare a stock solution. Instead, pure water is left in the atmosphere for a predetermined period of time. A stock solution may be prepared by adding only sodium chloride to the standing water.

  Even in such a configuration, the pH of the stock solution is determined by carbon dioxide in the atmosphere. Further, since the generation method and the generation apparatus are the same as those in the above-described embodiment, the description thereof is omitted here.

In this embodiment, the dissolved gas in the secondary product water 30 is removed by using the degassing module 11. However, since the concentration of the dissolved gas in the secondary product water 30 is low, a foaming phenomenon occurs. If there is no concern, the step of removing dissolved gas may be omitted. In such a case, the secondary product water 30 is sterilized water.
FIG. 40 is a diagram showing the generation device 21a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generation device 21.

Moreover, although this embodiment demonstrated the example which produces | generates sterilizing water so that pH might be 6.3-6.7 or 6.3-7, it is so that pH may be 5.6-6.3. The same procedure can be followed when producing sterilized water.
Further, in the present embodiment, the sterilizing water, the generation method and the generation apparatus for the purpose of sterilization of periodontal disease bacteria that inhabit in the periodontal pocket have been described, but the sterilizing water according to the present invention is hypochlorous acid. Since the concentration of (HCLO) is 201 to 600 ppm and the pH is 6.3 to 7, the bactericidal power is inherently strong and the pH is near neutral. I can't.

  Therefore, the use of the sterilizing water according to the present invention is not limited to the sterilization of periodontal disease bacteria that inhabit the periodontal pocket, and can be applied to sterilization of any part of the human body and any part. In addition, the application target is not limited to the human body.

  In particular, if the dissolved gas is removed, it is possible to prevent bleeding from the wound due to the foaming phenomenon and prevent germs from entering the body. It is a very useful tool.

  In addition, it cannot be overemphasized that the production | generation method and production | generation apparatus of this embodiment can apply the production | generation method and production | generation apparatus of this sterilization water as they are.

(Experiment on the production of sterilized water)
First, tap water was poured into a water purifier equipped with a reverse osmosis membrane, and then sodium chloride (NaCL) was added to the water that passed through the reverse osmosis membrane to prepare a stock solution.

  Next, the stock solution was electrolyzed in an electrolytic cell to produce primary product water, and the primary product water was diluted with tap water.

  The electrolytic cell used was an electrolytic neutral water generating device sold by Sakai Engineering Co., Ltd. under the trade name “Epios Eco”.

  In addition, the relative position of the discharge pipe and the dilution water tank was positioned so that the tip of the discharge pipe connected to the electrolytic cell was below the level of the dilution water stored in the dilution water tank. .

  When electrolysis and dilution were performed by the above process, 500 ppm of sterilized water could be generated within the pH range of 6.3 to 6.7. In measuring the concentration of hypochlorous acid (HCLO) in the sterilized water, since there was no instrument, test paper or reagent capable of measuring a concentration exceeding 200 ppm, the measurement was performed by repeating twice the dilution twice.

  In addition, as a control (standard reagent) for confirming the effect of 500 ppm of sterilizing water, 200 ppm of sterilizing water was also prepared in the same procedure.

(Clinical trial using sterilized water)
While removing the biofilm with an ultrasonic scaler, a clinical test was conducted in which sterilized water was injected into the periodontal pocket through an irrigation chip attached to the tip. The injection time was 10 seconds to avoid bacteremia.

  First, treatment is performed by injecting sterilized water having a concentration of hypochlorous acid (HCLO) of 200 ppm and a pH of 6.3 to 6.7, and then the probe is placed on the bottom of the periodontal pocket without touching saliva. Plaques and blood that were inserted and adhered to the root surface were collected, placed on a slide glass, suspended in physiological saline, covered with a cover glass, and observed with a high-resolution phase contrast microscope of 3600 times.

  The results are shown in FIGS. As can be seen from these figures, scaling with 200 ppm hypochlorous acid water can confirm some bactericidal effect, but Campylobacter rectus and Treponema denticola are still active. It can be seen that complete sterilization has not been performed. In addition, the result of this example also supported the test result of Example 1.

  Therefore, sterilized water with a concentration of hypochlorous acid (HCLO) of 200 ppm cannot sufficiently kill periodontal pathogens, but on the contrary, the periodontal pathogens can rapidly grow in the periodontal pockets due to the bacterial change phenomenon It can be concluded that there is sex.

  Next, a similar test was performed using sterilized water having a concentration of hypochlorous acid (HCLO) of 500 ppm and a pH of 6.3 to 6.7.

  The results are shown in FIGS. As can be seen from these figures, it is understood that Campylobacter rectus and Treponema denticola are completely killed by ligation using hypochlorous acid water of 500 ppm. Moreover, the result of the present Example also supported the test result of Example 3.

Claims (18)

In sterilized water containing hypochlorous acid (HCLO),
A sterilized water characterized in that the concentration of the hypochlorous acid (HCLO) is 201 to 600 ppm, the pH is 5.6 to 7, and the sterilization of periodontal disease bacteria living in the periodontal pocket is used. The sterilizing water according to claim 1, wherein the water content is 400 to 600 ppm instead of the 201 to 600 ppm. The sterilizing water according to claim 1 or 2, wherein 6.3 to 6.7 is used instead of 5.6 to 7. The sterilizing water according to claim 1 or 2, wherein 5.6 to 6.3 is used instead of 5.6 to 7. In sterilized water containing hypochlorous acid (HCLO),
Bactericidal water characterized in that the concentration of hypochlorous acid (HCLO) is 201 to 600 ppm and the pH is 5.6 to 7. By diluting the primary product water obtained by electrolyzing a stock solution obtained by adding sodium chloride and acid to water, sterilized water for sterilization of periodontal disease bacteria living in the periodontal pocket is generated. A method for producing sterilizing water, comprising a sodium chloride and an added amount of the acid so that the concentration of hypochlorous acid contained in the sterilizing water is 201 to 600 ppm and the pH is 5.6 to 7. The composition conditions, electrolysis conditions and dilution conditions are set, and after preparing the stock solution according to the stock solution composition conditions, the stock solution is electrolyzed according to the electrolysis conditions, and then the primary product water generated by the electrolysis is obtained. And diluting according to the diluting conditions. In the diluting step, primary generated water is injected into the diluting water through a predetermined discharge pipe, and at the time of injection, the tip position of the discharge pipe is lower than the water level of the diluting water. Method for generating sterile water, characterized in that to make the. Water is passed through a reverse osmosis membrane, and only sodium chloride is added to the passing water to make a stock solution. The stock solution is electrolyzed to primary product water, and the primary product water is diluted to hypochlorous acid (HCLO). ) For producing sterilized water, wherein the concentration of hypochlorous acid contained in the sterilized water is 201 to 600 ppm and the pH of the sodium chloride is 5.6 to 7. After setting the stock solution composition conditions including the addition amount, electrolysis conditions and dilution conditions, and preparing the stock solution according to the stock solution composition conditions, the stock solution was electrolyzed according to the electrolysis conditions, and then produced by electrolysis The method comprises a step of diluting primary product water according to the dilution conditions. In the dilution step, the primary product water is injected into the dilution water through a predetermined discharge pipe. Dilution water level or less Method for generating sterile water, characterized in that to make the. Pure water is left in the atmosphere for a predetermined period, and only sodium chloride is added to the left water to make a stock solution. The stock solution is electrolyzed to primary product water, and the primary product water is diluted to hypochlorous acid. A method for producing sterilizing water containing acid (HCLO), wherein the concentration of hypochlorous acid contained in the sterilizing water is 201 to 600 ppm, and the pH is 5.6 to 7. After setting the stock solution composition conditions including the amount of sodium chloride, electrolysis conditions and dilution conditions, and preparing the stock solution according to the stock solution composition conditions, the stock solution is electrolyzed according to the electrolysis conditions, and then electrolyzed. It comprises a step of diluting the generated primary product water according to the dilution conditions, and in the dilution step, the primary product water is injected into the dilution water through a predetermined discharge pipe, and at the time of injection, the discharge pipe The tip position is diluted Method for generating sterile water, characterized in that to make the following level. The pH of the stock solution is calculated using the solubility of carbon dioxide at the temperature at which the stock solution is prepared and the concentration of carbon dioxide in the atmosphere, and using the calculated value, the stock solution composition conditions, the electrolysis conditions, and the The method for producing sterilizing water according to claim 7 or 8, wherein dilution conditions are set. The method for producing sterilizing water according to any one of claims 6 to 9, wherein 400 to 600 ppm is used instead of the 201 to 600 ppm. The method for producing sterilized water according to any one of claims 6 to 9, wherein 6.3 to 6.7 is used instead of 5.6 to 7. The method for producing sterilizing water according to any one of claims 6 to 9, wherein 5.6 to 6.3 is used instead of 5.6 to 7. In an apparatus for producing sterilized water containing hypochlorous acid (HCLO) by electrolyzing a stock solution in an electrolytic cell,
The discharge pipe is provided with a stock solution tank for storing the stock solution, an electrolytic bath connected to the stock solution tank, a discharge pipe connected to the electrolytic tank, and a dilution water tank storing dilution water. The position of the dilution water tank relative to the tip position of the discharge pipe is relatively positioned so that the tip of the dilution water is equal to or lower than the level of the dilution water stored in the dilution water tank, and inhabits the periodontal pocket. A sterilizing water generating device for generating sterilizing water for sterilization of periodontal disease bacteria. A sterilizing water generator for generating sterilized water for sterilization of periodontal disease bacteria inhabiting the periodontal pocket, in which only sodium chloride is added to the passing water obtained by passing the water through the reverse osmosis membrane A stock solution tank for storing the stock solution, an electrolytic tank connected to the stock solution tank for electrolyzing the stock solution to produce primary product water, and a discharge pipe connected to the electrolytic tank. A dilution water tank is prepared by diluting the primary product water to be sterilized water in advance and relatively positioning the discharge pipe so that the tip of the discharge pipe is below the level of the dilution water. The amount of sodium chloride added is determined so that the concentration of hypochlorous acid (HCLO) in the sterilized water is 201 to 600 ppm and the pH is 5.6 to 7, and Define operating conditions or set dilution conditions Generator of sterile water, characterized in that the. A sterilizing water generating device for generating sterilizing water for the sterilization of periodontal disease bacteria living in the periodontal pocket, and only sodium chloride is contained in the standing water obtained by leaving pure water in the atmosphere for a predetermined period. Via a stock solution tank for storing a stock solution to which is added, an electrolytic bath connected to the stock solution tank for electrolyzing the stock solution to generate primary product water, and a discharge pipe connected to the electrolytic bath. The discharge pipe is relatively positioned so that the dilution water used as the sterilization water by diluting the primary generated water discharged in advance is stored in advance and the tip of the discharge pipe is below the water level of the dilution water. A dilution water tank, and the amount of sodium chloride added is determined so that the concentration of hypochlorous acid (HCLO) in the sterilized water is 201 to 600 ppm and the pH is 5.6 to 7, Define or rarely operate the electrolytic cell Generator of sterile water, characterized in that defining the condition. The apparatus for producing sterilizing water according to any one of claims 13 to 15, wherein 400 to 600 ppm is used instead of the 201 to 600 ppm. The apparatus for producing sterilized water according to any one of claims 13 to 15, wherein 6.3 to 6.7 is used instead of 5.6 to 7. The apparatus for producing sterilized water according to any one of claims 13 to 15, wherein 5.6 to 6.3 is used instead of 5.6 to 7.