KR100336702B1 - An irritant liquid for root canal of tooth - Google Patents
An irritant liquid for root canal of tooth Download PDFInfo
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- KR100336702B1 KR100336702B1 KR1020000004562A KR20000004562A KR100336702B1 KR 100336702 B1 KR100336702 B1 KR 100336702B1 KR 1020000004562 A KR1020000004562 A KR 1020000004562A KR 20000004562 A KR20000004562 A KR 20000004562A KR 100336702 B1 KR100336702 B1 KR 100336702B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
본 발명은 증류수 74~76중량%, 에틸렌디아민테트라아세틱에시드(EDTA) 14~16중량%, 에탄올 4~6중량% 및 세틸피리디니움클로라이드(Cetylpridinium chloride) 2~8중량%로 구성됨을 특징으로 하는 치아 근관 세척액에 관한 것이다.The present invention comprises 74 to 76% by weight of distilled water, 14 to 16% by weight of ethylenediaminetetraacetic acid (EDTA), 4 to 6% by weight of ethanol and 2 to 8% by weight of cetylpyridinium chloride (Cetylpridinium chloride). It relates to a dental root canal cleaning solution.
본 발명은 근관내 상아질 제거가 용이하고, 근관세척효과 및 탈취효과가 우수하여 좁은 근관이나 석회화되어 확대가 힘든 근관 세척에 유용하다.The present invention is easy to remove the dentin in the root canal, excellent in the root canal washing effect and deodorizing effect is useful for narrow root canal or calcified difficult root canal cleaning.
Description
본 발명은 치과에서 치아치료시 근관내에 존재하는 세균 등을 세척하는데 사용되는 치아 근관 세척액에 관한 것이다.The present invention relates to a dental root canal cleaning solution used to wash bacteria and the like present in the root canal during dental treatment in the dentist.
치과에서는 썩은 치아를 치료하는 방법으로 치아의 썩은 부위를 치과용 천공기나 치아 근관 세척액 등을 사용하여 제거하고 치료 부위인 근관을 근관충전물질을 사용하여 충전시키고 밀폐시키는 방법으로 썩은 치아를 치료 해 오고 있다.Dentists have been treating rotten teeth by removing the rotten parts of the teeth with a dental puncturing machine or dental root canal cleaning solution, and filling and sealing the root canal with the root canal filling material. have.
근관 치료에 앞서서 근관 내 세균이나 조직 잔사, 감염 상아질, 상아질 삭편 등은 근관기구 등을 이용해서 기계적으로 제거하기도 하지만, 이러한 근관 내용물 등을 근관 세척 없이 기계적으로만 완전히 청소한다는 것은 불가능하기 때문에 최근에 와서 많은 임상의들이 근관 세척에 근관 세척액을 많이 이용하고 있다. 지금까지 사용되고 있는 근관 세척액의 재료로서는 30% 요소용액, 글리세린, 과산화요소, 3% 과산화수소, 크로라민용액, 생리적식염수, 차아염소산나트륨, 에틸렌디아민테트라아세틱에시드[ethylendiamine tetraacetic acid(이하 'EDTA'라고 한다)], 치아염소산나트륨과 과산화수소 또는 EDTA의 혼합액 등이 사용되고 있다.Prior to root canal treatment, bacteria and tissue residues, infected dentin, and dentin fragments in the root canal are mechanically removed using a root canal instrument, but it is not possible to completely clean the root canal contents only mechanically without root canal cleaning. Many clinicians have been using a lot of canal lavage in the root canal cleaning. The materials used for the root canal lavage are 30% urea solution, glycerin, urea peroxide, 3% hydrogen peroxide, chloramine solution, physiological saline solution, sodium hypochlorite, ethylenediamine tetraacetic acid (hereinafter referred to as 'EDTA'). ), A mixed solution of sodium hypochlorite and hydrogen peroxide or EDTA is used.
일반적으로 근관 세척액으로 가져야할 이상적인 성질은 첫째, 근관 내용물을 효과적으로 제거하고, 둘째 항균효과가 있고, 셋째 괴사 및 생활 치수조직에 용해작용이 있고, 네째 치근단 조직에 유해작용이 없어야 한다. 이 모든 요구조건을 만족시켜 주는 약제는 아직 없지만 이들 중 5.25% 차아염소산나트륨이 세척액으로서 가져야 할 대부분의 성질을 갖추고 있으며 다른 세척액과 비교해서 효과적인 세척액으로 알려져 있다.In general, the ideal properties of the root canal cleaning solution should be first, the effective removal of the root canal contents, second antibacterial effect, third, lytic action on necrosis and living pulp tissue, and fourth, no harmful action on the root root tissue. There is no medicament that satisfies all these requirements, but 5.25% of sodium hypochlorite has most of the properties that it should have as a washing liquid and is known as an effective washing liquid compared to other washing liquids.
임상의에 따라서는 차아염소산나트륨과 과산화수소, 또는 글리옥사이드 (Glyoxide)를 병용하는 것이 가장 좋은 세척방법이라고 주장하고 있다. 그 이유는 근관 내에서 이들이 상호작용해서 발포(effervescence)가 생기고 이로 인해 근관내 잔사와 세균을 부양해서 근관 입구쪽으로 밀어내게 되기 때문이다. 또 동시에 세균을 죽이는 데 유효한 발생기 산소가 생기기 때문이다. 그러나 상기 종래의 치아 근관 세척액은 일반 세척력은 우수하나 근관내 상아질을 제거하기 힘든 문제가 있었다.Clinicians claim that the best cleaning method is the combination of sodium hypochlorite and hydrogen peroxide or glyoxide. The reason is that they interact in the root canal, causing effervescence, which in turn causes the residue and bacteria in the root canal to be pushed towards the root canal entrance. At the same time, it produces generator oxygen, which is effective for killing bacteria. However, the conventional dental root canal cleaning solution has a problem that it is difficult to remove the dentin in the root canal but excellent general cleaning power.
한편 근래에 와서는 기계적 근관 형성시 근관 내면에 생기는 도말층(smear layer)을 제거하기 위하여 탈회효과가 있는 EDTA나 구연산이 세척액으로 이용되고 있으며 EDTA와 차아염소산나트륨을 병용한 경우 도말층 제거효과는 물론이고 세척액의 약물효과와 무관하게 세척이 잘되지 않는 것으로 알려진 근관의 근단 1/3 부위에서도 다른 세척액들에 비해 효과가 있다고 알려져 있다.In recent years, EDTA or citric acid, which has a deliming effect, is used as a washing solution to remove the smear layer on the inner surface of the root canal during mechanical root canal formation, and when EDTA and sodium hypochlorite are used in combination, as well as removing the smear layer, Irrespective of the drug effect of the washing solution, it is also known to be effective compared to other washing solutions in the root end 1/3 of the root canal, which is known to be poorly washed.
보다 구체적으로 EDTA 15중량%, 우레아퍼옥시드(Urea Peroxide) 10중량%, 증류수 75중량%로 구성된 치아 근관 세척액이 널리 사용되고 있다. 상기 치아 근관 세척액은 상아질내 칼슘이온과 강한 결합력이 있는 EDTA를 함유하고 있어서 치아 근관 내 상아질을 제거하기 쉬운 장점은 있지만, 구성성분 중 우레아퍼옥시드가 산화제 역할을 하기 때문에 과량 사용시 치아 근관 조직에 유해한 문제가 있다.More specifically, dental root canal cleaning solution consisting of 15% by weight of EDTA, 10% by weight of urea peroxide (Urea Peroxide), 75% by weight of distilled water is widely used. The dental root canal cleaning liquid contains EDTA which has strong binding strength with calcium ion in dentin, so it is easy to remove dentin in dental root canal, but it is harmful to dental root canal tissue when excessive use is made because urea peroxide acts as an oxidizing agent among the components. there is a problem.
한편 EDTA 17중량%와 증류수 83중량%로 구성된 치아 근관 세척액도 널리 사용되고 있다. 상기 치아 근관 세척액은 우레아퍼옥시드를 함유하고 있지 않아서 인체에 무해하지만 세척력이 다소 부족한 문제가 있다.On the other hand, dental root canal cleaning solution consisting of 17% by weight of EDTA and 83% by weight of distilled water is also widely used. The dental root canal washing solution does not contain urea peroxide, so it is harmless to the human body, but there is a problem that the washing power is somewhat insufficient.
본 발명은 이상에서 설명한 종래의 치아 근관 세척액들의 문제점을 해결하므로서 세척력이 우수함과 동시에 치아 근관내 상아질 제거가 용이하며, 인체에 유해하지 않고 항균 및 탈취효과도 우수한 치아 근관 세척액을 제공하고자 한다.The present invention solves the problems of the conventional dental root canal cleaning fluids described above, while providing excellent cleaning power and easy removal of dentin in the dental root canal, it is intended to provide a dental root canal cleaning solution having excellent antibacterial and deodorizing effects.
또한 본 발명은 좁은 근관이나 석회화되어 확대가 힘든 근관도 용이하게 세척할 수 있는 액상의 치아근관 세척액을 제공하고자 한다.In another aspect, the present invention is to provide a liquid dental root canal cleaning liquid that can easily wash the narrow canal or calcified difficult root canal.
본 발명은 치아 치료시에 사용하는 치아 근관 세척액에 관한 것이다.The present invention relates to a dental root canal cleaning liquid for use in treating teeth.
더욱 구체적으로 본 발명은 증류수 74~76중량%, 에틸렌디아민테트라아세틱에시드(EDTA) 14~16중량%, 에탄올 4~6중량% 및 세틸피리디니움클로라이드 (Cetylpridinium chloride) 2~8중량%로 구성됨을 특징으로 하는 치아 근관 세척액에 관한 것이다.More specifically, the present invention is 74 to 76% by weight of distilled water, 14 to 16% by weight of ethylenediaminetetraacetic acid (EDTA), 4 to 6% by weight of ethanol and 2 to 8% by weight of cetylpyridinium chloride (Cetylpridinium chloride) It relates to a dental root canal cleaning solution characterized in that the configuration.
이하 본 발명을 상세하게 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 (ⅰ)증류수에 (ⅱ)여섯자리리간드로서 여러 가지 무기물질과 상아질내 칼슘이온과 강한 결합을 해서 킬레이팅역할, 항균작용, 적당한자극성, 도말층제거 등의 역할을 하는 EDTA, (ⅲ)항균효과와 유기물을 잘 용해와 시킬 수 있는 에탄올, (ⅳ)살균제, 방향제 및 청정제로서의 역할을 할 수 있는 세틸피리디니움클로라이드(Cetylpiridinium chloride)를 첨가하여 제조한다.The present invention is (i) EDTA, which acts as a chelating role, antimicrobial action, moderate stimulation, removal of smear layer by binding strongly to various inorganic substances and calcium ions in dentin as (ii) six-digit ligand in distilled water. It is prepared by adding ethanol, disinfectant, fragrance and detergent which can dissolve and dissolve organic matters well as Cetylpiridinium chloride.
이들 성분의 함량은 증류수 74~76중량%, EDTA 14~16중량%, 에탄올 4~6중량% 및 세틸피리디니움클로라이드 2~8중량% 이다. EDTA의 함량이 상기 범위보다 낮을 경우에는 근관 내 상아질 제거효과 등이 저하되며, 상기 범위보다 높을 경우에는 에탄올 등의 기타성분 함량이 낮아져 세척력이 저하된다. 에탄올의 함량이 상기 범위보다 낮을 경우에는 근관 세척력이 저하되며, 세틸피리디니움클로라이드 함량이 상기 범위보다 낮을 경우에는 살균효과 및 탈취효과가 저하되어 치료시 상쾌한 느낌을 줄 수 없다.The content of these components is 74 to 76% by weight of distilled water, 14 to 16% by weight of EDTA, 4 to 6% by weight of ethanol and 2 to 8% by weight of cetylpyridinium chloride. When the content of EDTA is lower than the above range, dentin removal effect in the root canal is lowered. When the content of EDTA is higher than the above range, the content of other components such as ethanol is lowered and the washing power is lowered. When the content of ethanol is lower than the above range, the root canal washing power is lowered, and when the cetylpyridinium chloride content is lower than the above range, the bactericidal effect and the deodorizing effect are lowered, so that the treatment can not be refreshed.
본 발명의 구성성분중 하나인 세틸피리디니움클로라이드는 방향제 및 청정제 역할을 하여 치료 받는 사람에게 상쾌한 느낌을 준다. 그 결과 노약자, 어린이, 비위가 약한 사람 등도 거부감 없이 치아 치료를 받을 수 있게 된다.Cetylpyridinium chloride, one of the constituents of the present invention, acts as a fragrance and detergent to give a refreshing feeling to the treated person. As a result, the elderly, children, and those with weak stomachs can receive dental treatment without objection.
EDTA 성분은 상아질내 칼슘이온과 강한 결합을 하여 근관내 상아질 제거를 용이하게 하고, 항균작용 및 도말층 제거 기능도 한다. 에탄올 성분은 항균효과와 더불어 근관내 유기물을 용해 시키는 역할을 하여 세척력을 향상 시킨다.EDTA component has strong binding to calcium ion in dentin to facilitate dentin removal in the root canal, antibacterial action and smear removal. In addition to the antibacterial effect, ethanol also dissolves organic matter in the root canal, improving washing power.
따라서 본 발명은 근관내 세균, 유기물은 물론이고 상아질까지 쉽게 제거할수 있으며, 인체에도 무해하다. 더욱 치료시 상쾌한 느낌을 부여하여 거부감 없이 치아를 치료할 수 있는 효과도 있다.Therefore, the present invention can easily remove dentin, as well as bacteria, organic matter in the root canal, harmless to the human body. There is also an effect that can treat teeth without rejection by giving a refreshing feeling at the time of treatment.
본 발명은 상아질내 칼슘이온과 결합하여 칼슘-킬레이트 화합물(Cacium-chelate)을 형성하는 리간드 역할을 하는 EDTA를 함유하고 있어서 치아 근관내 상아질을 제거하는 능력이 매우 우수하다.The present invention contains EDTA, which acts as a ligand that binds to calcium ions in dentin to form a calcium-chelate, and thus has excellent ability to remove dentin in the root canal.
아울러 항균성과 용해성이 우수한 에탄올과 방향성과 청정성이 우수한 세틸피리디니움클로라이드를 함유하고 있어서 세척효과, 항균효과, 도말층 제거효과 및 탈취효과가 매우 우수하다. 특히 본 발명은 액상이기 때문에 좁은 근관이나 석회화 되어 확대가 힘든 근관 세척에 매우 유용하다.In addition, it contains ethanol with excellent antibacterial and solubility and cetylpyridinium chloride with excellent fragrance and cleanliness, so it has excellent washing, antibacterial, smear removal and deodorizing effect. In particular, the present invention is very useful for the cleaning of the root canal is difficult to enlarge because of the liquid phase narrow or calcified.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US705968A (en) * | 1901-10-02 | 1902-07-29 | John F Haas | Vehicle-wheel spindle. |
| US5236699A (en) * | 1992-06-22 | 1993-08-17 | Libin Barry M | Antiplaque mouth rinse |
| WO1999034765A1 (en) * | 1998-01-09 | 1999-07-15 | Mediteam Dentalutveckling I Göteborg Ab | Preparation for dental treatment |
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