JP2001269393A - Physiological salt water having sterilizing action, sterilizing wash water using it, and manufacturing method thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide physiological salt water suitable for medical practice, having sterilizing action itself so that it is usable over a wide range for sterilization purposes and is safely applicable to human bodies. SOLUTION: This physiological salt water is obtained by dissolving a predetermined amount of sodium chloride into electrolytic water obtained by electrolyzing an aqueous solution of hydrochloric acid which does not substantially contain sodium chloride.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a physiological saline having a bactericidal action, various kinds of cleaning and disinfecting water using the same, and a method for producing the same. More specifically, the present invention relates to a physiological saline solution which does not contain a chemical bactericide, is safe for the human body, and has a bactericidal action, and various kinds of cleaning and disinfecting water utilizing the same, and a physiological saline solution having a bactericidal action. And a method for producing the same.

[0002]

2. Description of the Related Art Conventionally, physiological saline is frequently used in fields such as medical treatment and dental care. Generally, physiological saline is prepared by dissolving 9 g of sodium chloride in distilled water and adding a total amount of 10 g.
It is prepared as 00 ml (0.9% by weight) and is also called “physiological saline solution”, “isotonic saline solution” or the like. Such physiological saline is rarely used for physiological experiments. In this case, the concentration of sodium chloride is not limited to 0.9% by weight, but is adjusted according to the purpose of use. You.

[0003] As the normal physiological saline, commercially available products filled in bottles, plastic containers and the like are used. In some cases, such physiological saline is used in a sterile state. For example, when physiological saline is used as a cleaning solution for soft contact lenses, various preservatives,
A sterilizing agent is added to make it aseptic, and this is used for cleaning and disinfecting soft contact lenses. Described as technology 1.). Another technique for producing such a sterile physiological saline is a technique of preparing a physiological saline and then irradiating it with gamma rays for sterilization (Japanese Patent Publication No. 59-39139, hereinafter referred to as Conventional Technique 2). And a technique of removing dissolved oxygen after preparing a physiological saline solution and irradiating it with ionizing radiation for sterilization (Japanese Patent Publication No. 8-7336, hereinafter referred to as Conventional Technique 3). Have been.

On the other hand, in recent years, electrolyzed water obtained by electrolyzing various solutions has been known, and the application technology of such electrolyzed water is urgently established (Kiyoko Shiba et al., "Strong electrolysis"). Water Handbook ", Medical Information Company, 1995). Conventional electrolyzed water has been produced by, for example, a technique disclosed in Japanese Patent Application Laid-Open No. 1-180293 (hereinafter referred to as Reference Technique 1). In this technique, water to which salt is added is passed through an electrolytic cell provided with a diaphragm, which is electrolyzed to obtain strongly acidic water generated on the anode side as electrolytic water. The pH of the electrolyzed water is 1.5 or more and 3.2 or less, and it is said that the sterilizing effect is higher than a simple low pH solution.

Further, electrolyzed water produced by the technique disclosed in Japanese Patent No. 2627100 (hereinafter referred to as Reference Technique 2) is obtained by mixing water containing sodium chloride and water containing hydrochloric acid. This is obtained by electrolyzing this in a non-diaphragm electrolytic cell. In this case, the water to which sodium chloride has been added is regarded as an indispensable additive for increasing the electrolysis efficiency at the time of electrolysis. In addition, the present inventors have previously described the technology of electrolyzed water that is neutral and contains substantially no sodium (Japanese Patent Application No. 8-309920; hereinafter sometimes referred to as electrolyzed water of the prior application). Has applied for a patent. The water to which these electrolyzed waters are added has, for example, a higher sterilizing effect even at a low chlorine concentration, and is used every time as compared to a case where sodium hypochlorite is simply added to water. It is excellent in that it is not necessary to adjust the concentration of chlorine every time. However, a technique for applying these electrolyzed waters to physiological saline has not been known.

[0006]

The sterile physiological saline obtained by the prior art 1 contains a bactericide, a preservative, and the like, and therefore has a problem when applied to the human body, and has a problem in terms of safety. Therefore, it was not always suitable for use in the medical field. Further, in the above-mentioned prior art 2 and prior art 3, since both perform gamma rays and ionizing radiation,
There is a problem that the manufacturing apparatus becomes large-scale, and the investment cost and the manufacturing cost are high. Further, the obtained sterile physiological saline is merely in a sterile state, and has no bactericidal action itself. Therefore, there is a problem that when left untreated, there is a risk of enrichment, and furthermore, it cannot be used for the purpose of disinfection, and its use is limited.

[0007] The inventors of the present invention have applied for a patent application for a neutral and substantially sodium-free electrolyzed water (Japanese Patent Application No. Hei 8-
Electrolyzed water of the prior application of No. 309920. In the course of intensive research on the use of (2), the inventors have found that electrolyzed water can generally be suitably applied to sterile physiological saline, and completed the present invention. The object of the present invention is that it does not contain a bactericide, a preservative, etc., can be safely applied to the human body, is suitable for medical practice, and has a bactericidal action itself, and is widely used for disinfection. It is an object of the present invention to provide a sterile physiological saline that can be used, can be easily prepared with a simple device, and has low investment and manufacturing costs. Another object of the present invention is to provide various kinds of cleaning and disinfecting water using such physiological saline. Another object of the present invention is to provide a method for producing such a saline solution.

[0008]

A first aspect of the present invention for solving the above-mentioned problems is to add a predetermined amount of sodium chloride to electrolyzed water obtained by electrolyzing a hydrochloric acid aqueous solution containing substantially no sodium chloride. Physiological saline having a bactericidal action. Further, the first invention of the present invention is that the electrolyzed water is electrolyzed by a non-diaphragm electrolytic cell,
In a preferred embodiment, the aqueous hydrochloric acid solution is prepared by adding hydrochloric acid to pure water, and the concentration of sodium chloride is 0.9% by weight.

A second aspect of the present invention for solving the above-mentioned problems is a skin cleaning / disinfecting water, an affected area cleaning / disinfecting water, a medical instrument cleaning / disinfecting water, and a dental cleaning liquid comprising the physiological saline of the first invention. Disinfecting water or ophthalmic cleaning disinfecting water. A third invention of the present invention for solving the above-mentioned problems is that hydrochloric acid is added to water substantially free of sodium chloride, and the resulting hydrochloric acid-added water is passed through a non-separated membrane electric field to electrolyze. A method for producing physiological saline having a bactericidal action, characterized by adding a predetermined amount of sodium chloride to electrolyzed electrolyzed water. Next, the present invention will be described in detail.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION A first aspect of the present invention is a physiological saline having a bactericidal action, which is obtained by adding a predetermined amount of sodium chloride to an aqueous solution of a hydrochloric acid aqueous solution containing substantially no sodium chloride and dissolving the same. ,. The “hydrochloric acid aqueous solution containing substantially no sodium chloride” means, for example, an aqueous hydrochloric acid solution in which an operation of artificially adding sodium chloride is not performed, such as electrolyzed water of the prior application.

The physiological saline of the present invention is obtained by dissolving a predetermined amount of sodium chloride in water obtained by electrolyzing such an aqueous hydrochloric acid solution as raw water. The electrolyzed water used as a raw material in the present invention is desirably an electrolyzed water having a sodium ion concentration of 200 ppm or less (the electrolyzed water of the prior application). That is, unlike the above reference technology 1 or 2, the sodium ion concentration is 200 ppm or less, more preferably 10 pp, which is a standard water quality standard for drinking water.
m or less of electrolyzed water is used as a raw material.

The reason is as follows. That is, the electrolyzed water produced by the above-mentioned Reference Technique 1 and Reference Technique 2 is obtained by electrolyzing a solution containing sodium chloride. Therefore, since the sodium chloride concentration of the water after electrolysis varies depending on the conditions of electrolysis, it is difficult to prepare a physiological saline having a predetermined sodium chloride concentration.
However, as in the present invention, it is extremely easy to prepare a physiological saline having a predetermined concentration by using a material obtained by electrolysis of "a hydrochloric acid aqueous solution substantially containing no sodium chloride" as a raw material. Such electrolyzed water is desirably produced by the following procedure. That is, hydrochloric acid is added to water containing substantially no sodium chloride to adjust the hydrochloric acid-added water. Here, "water" refers to tap water, groundwater, underflow water, demineralized water, distilled water, purified water (eg, reverse osmosis treated water, membrane treated water, etc.), a mixed water thereof, and the like. It means that it does not contain sodium chloride.

The above-mentioned hydrochloric acid-added water is passed through an electrolytic cell, electrolyzed, and a predetermined amount of sodium chloride is added to the obtained electrolytic water to obtain a sterile physiological saline of the present invention having a bactericidal action. Can be. Any mode of adding sodium chloride may be used. For example, solid sodium chloride may be directly added to and dissolved in electrolyzed water, or a previously prepared aqueous solution of sodium chloride and electrolyzed water may be mixed.

[0014] Such an electrolysis operation is preferably performed in a non-diaphragm electrolytic cell. For example, the reference technology 1
Is a technique of electrolyzing using a diaphragm electrolyzer, and the obtained electrolyzed water is classified into either acidic water having a low pH or highly alkaline water having no bactericidal action. Therefore, it is difficult to obtain neutral physiological saline suitable for medical use with the electrolyzed water of Reference Technique 1. Therefore, if a non-diaphragm electrolytic cell is used, the pH of the obtained physiological saline is also around neutral, and the whole amount can be used without waste.
In this case, the physiological saline has a pH of 4.0 to 7.0.
Is desirably within the range.

The physiological saline of the present invention described above is not only sterile, but also has a bactericidal action itself. Therefore, there is no concern that the bacteria will increase even if left to some extent, and it can be used for the purpose of disinfection.
Moreover, since it is not what added the various preservatives and bactericides and added the bactericidal action like the said prior art 1, it is safe also for a human body. Moreover, the physiological saline of the present invention does not require treatment of gamma rays, ionizing radiation, etc., unlike the prior art 2 and the prior art 3, and equipment investment costs and manufacturing costs are low, and hospitals and dental clinics are inexpensive. There is an advantage that it can be easily used. Further, in the physiological saline of the present invention, it is preferable that the hydrochloric acid aqueous solution before electrolysis is obtained by adding hydrochloric acid to pure water.

When preparing an aqueous hydrochloric acid solution as described above, hydrochloric acid is added to water. As the "water", it is desirable to use pure water. Here, pure water means distillation,
It means water from which impurities have been removed by operations such as desalination, ion exchange, and ultrafiltration. In general, conventional normal saline is prepared by dissolving sodium chloride in distilled water, but using water free of impurities as a starting material in this way makes it difficult to obtain an isotonic saline solution. It is also desirable to ensure. Therefore, also in the present invention, it is desirable to use pure water as a starting material. Further, by using pure water as a starting material, there is an advantage that the concentration of sodium chloride can be easily adjusted in a later step.

Further, the physiological saline of the present invention has a concentration capable of ensuring isotonicity, for example, a sodium chloride concentration of 0.84.
In a preferred embodiment, the concentration is in the range of 0.94% by weight to 0.94% by weight, and more preferably 0.9% by weight. As described above, the physiological saline of the present invention can be used for physiological experiments, but the concentration of sodium chloride in this case is not limited to 0.9% by weight, but is adjusted according to the purpose of use. For example, when used in an experiment on birds, the sodium chloride concentration is adjusted to 0.75% by weight, and similarly, 0.80% by weight for amphibian rodents and 0.64% by weight for anuran. . However, when the physiological saline of the present invention is used for medical treatment and dental treatment, the normal standard of 0.9% by weight is most preferable,
From the point of isotonicity, this concentration has the highest utility value.

A second invention of the present invention is various kinds of cleaning and disinfecting water utilizing the physiological saline of the first invention. The skin cleaning and disinfecting water is composed of the physiological saline of the first invention,
For example, in addition to washing and disinfecting hands and fingers, it can be suitably used for washing and disinfecting mucous membrane parts such as vagina and nasal cavity, and other parts of skin. As a mode of use, in addition to a mode in which the skin cleaning / disinfecting water is allowed to flow and the hands and fingers are exposed to perform cleaning and disinfecting, a mode in which the skin cleaning / disinfecting water is dipped in a cloth and the skin is wiped, and the skin is sprayed. And an embodiment in which the washing is performed by storing in a washing bottle.
Affected part cleaning and disinfecting water is water for cleaning and disinfecting a surgical site, a suppuration site, a wound surface, a skin disease site, and the like, and is stored in a cloth soaked in a compress, sprayed, or in a cleaning bottle. Examples of the washing mode and the like can be given. Since the affected area cleaning and disinfecting water is a physiological saline, it has isotonicity, and has a great advantage that even if the affected area is washed, it does not irritate the affected area and has a bactericidal action.

The medical instrument cleaning and disinfecting water is used for various medical instruments such as surgical instruments such as scalpels, tweezers, kanshi, transplantation tools such as artificial heart valves and artificial blood vessels, and endoscopes and medical rubber gloves. Can be used for cleaning and disinfection. still,
The medical devices in this case are not limited to those used in hospitals, but also include tweezers used at home. Oral cleansing water is used in the dental field in addition to gargle. For example, in addition to cleaning and disinfecting dentures, it can be used for cleaning and disinfecting tooth extraction marks, roots, etc., and water for air turbine handpieces. Ophthalmic cleaning and disinfecting water is used for eye drops, eye cleaning, contact lens cleaning,
Used for disinfection and storage. Needless to say, the various types of cleaning and disinfecting water should be adjusted to the optimum available chlorine concentration according to the purpose of use.

The third invention of the present invention is a method for producing the physiological saline of the first invention. The method of the present invention comprises a step of preparing a hydrochloric acid aqueous solution by adding hydrochloric acid to water containing substantially no sodium chloride, a step of passing the added water through a diaphragm-free electric field and electrolyzing, and an electrolyzed electrolysis. Dissolving a predetermined amount of sodium chloride in water. First, hydrochloric acid is added to water substantially free of sodium chloride to prepare hydrochloric acid-added water. As described above, the “water” here includes tap water, groundwater, underflow water, demineralized water, distilled water, purified water (for example, reverse osmosis treated water, membrane treated water, etc.), a mixed water thereof, and the like. , Which does not substantially contain sodium chloride. As described above, the meaning of "substantially does not contain sodium chloride" means that sodium chloride is not artificially added,
In the present invention, it is desirable not to add not only sodium chloride but also alkali metal chloride as a whole.
In this case, it is needless to say that it is desirable to use pure water as the “water”.

The hydrochloric acid-added water to which hydrochloric acid has been added is passed through a non-diaphragm electrolytic cell to be electrolyzed. Because it is a non-diaphragm electrolytic cell,
The cathodic water and the anodic water are not separated after electrolysis, and can be collectively obtained as neutral electrolytic water. Further, naturally, no sodium chloride is added to the electrolyzed water, in other words, the sodium ion concentration does not exceed the sodium ion concentration contained in the “water”. That is, the sodium ion concentration is 200 ppm or less.

The above operation is performed, for example, by adding 21% by weight or 3% by weight to a commercially available electrolyzed water producing apparatus, Pure Star (trade name, manufactured by Morinaga Engineering Co., Ltd .; the same applies hereinafter).
A tank storing a concentration of hydrochloric acid is installed. In the former case, a mixture of 21% by weight of hydrochloric acid and water is mixed and passed through a non-diaphragm electrolytic cell. In the latter case, only 3% by weight of hydrochloric acid is used. It is possible to produce electrolyzed water by passing water through a non-diaphragm electrolytic cell and electrolyzing continuously.

The electrolyzed water obtained by the above method has substantially no added sodium chloride, and has physical properties closer to natural water than the electrolyzed water according to Reference Technique 1 or Reference Technique 2. It is doing.

A physiological saline can be obtained by adding a predetermined amount of sodium chloride to the electrolyzed water thus obtained. In addition, the predetermined amount is an amount that becomes a concentration that can ensure the isotonicity of the target physiological saline. Such an electrolyzed water may be once diluted and adjusted to a predetermined chlorine concentration, and then sodium chloride may be added. When sodium chloride is added, solid sodium chloride may be dissolved in electrolyzed water.
It is also possible to add sodium chloride by preparing a saline solution and mixing the saline solution with the electrolytic water.

Such an electrolyzed water has an effective chlorine concentration of 1 p.
Even if diluted to a concentration range of pm to 2 ppm, the bactericidal effect is not lost. Therefore, the obtained physiological saline can exhibit a sufficient bactericidal effect while having a chlorine concentration safe for the human body. In addition, pH after dilution
It is desirable that the target be adjusted around neutral. Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples.

[0026]

EXAMPLE 1 First, an example of an apparatus for producing electrolyzed water used in the method of the present invention will be described. Pure Star (trademark, manufactured by Morinaga Engineering Co., Ltd., model PS-)
01) comprises a hydrochloric acid container storing 3% by weight of hydrochloric acid, and a hydrochloric acid supply line having a tip connected to the hydrochloric acid container and a terminal connected to the diaphragm-free electrolytic cell. A metering pump is provided in the middle part of the road.

The diaphragm-free electrolytic cell connected to the end of the hydrochloric acid supply pipe is a device for electrolyzing hydrochloric acid. An electrolytic water pipe is provided on the discharge side of the non-diaphragm electrolytic cell, and discharges electrolytic water. The pure star having the above structure was operated as follows to prepare a physiological saline. First, dilute hydrochloric acid was added to demineralized water to prepare hydrochloric acid having a concentration of 3% by weight, and this was stored in a pure hydrochloric acid container. 3 from hydrochloric acid container
Hydrochloric acid at a concentration of 120 wt.
Hydrochloric acid was flowed into the non-diaphragm electrolytic cell at a rate of ml / h, and in this state, electricity was supplied to the non-diaphragm electrolytic cell under the condition of 4.5 A to electrolyze the hydrochloric acid.

The electrolyzed water after the electrolysis was discharged through an electrolyzed water pipe. At this time, unnecessary hydrogen gas was removed by a gas separator. This electrolyzed water had an effective chlorine concentration of 10 ppm. The effective chlorine concentration can be determined by the iodine titration method or the OT method (Japan Water Works Association, “Water Water Test Method, 1993 Edition”, pp. 212-219, 1993 November
(May 15) (the same applies hereinafter). Sodium chloride was added at a ratio of 9 g per 1000 ml of the obtained electrolyzed water to dissolve the sodium chloride, and finally a physiological saline having a sodium chloride concentration of 0.9% by weight was obtained.

Example 2 If a razor loses trauma to 50 male panelists 20 to 40 years old after shaving, washing and disinfection are performed using the physiological saline prepared according to the method of Example 1. Then, the feeling of use was heard by a questionnaire. As a result, all responded that the saline had no trauma and no discomfort during use.

Example 3 The physiological saline prepared by the method of Example 1 was allowed to flow down from a faucet to wash hands freely in a toilet in a toilet used by 100 men and women aged 20 to 40 years. Anke
And listened to it. As a result, all of the respondents answered that the feeling of use was good, and none of them had abnormalities such as rough hands and itching. In addition, a known method using a food stamp (standard agar for viable cell count) (Kyoko Shiba, "Electrolytic Water Handbook", pp. 65-66, Medical Information Company, September 1, 1995) As a result of confirming the bactericidal effect by hand washing according to (day), it was confirmed that the physiological saline solution of the present invention had the same bactericidal effect as ordinary electrolyzed water (electrolyzed water of the prior application).

Example 4 As a result of having 60 male and female panelers aged 20 to 40 years wash their mouths with the physiological saline prepared by the method of Example 1, no panelists complained of abnormalities. Washing,
Could be disinfected. In addition, as a result of confirming the bactericidal effect in the oral cavity by a known method (Kiyoko Shiba et al., "Handbook of Strong Electrolyzed Water", pages 62-63, Medical Information Company, September 1, 1995) It was confirmed that the physiological saline of the present invention has an oral sterilization effect.

Example 5 After the endoscope inspection, the scope was removed, the outer surface and the inner surface of the conduit were thoroughly washed with a detergent, and the electrolytic current was increased in the same manner as in Example 1 except that the electrolytic current was increased. It was washed with the prepared physiological saline (effective chlorine concentration: 30 ppm) and further immersed in the physiological saline of the present invention for about 5 minutes to disinfect it. Wipe the outer surface with a sterile gauze, and use standard agar medium at 35 ° C 4
A bacterial test was performed under the condition of 8 hours, but no bacteria were detected.

Example 6 A normal saline solution was added to and diluted with a saline solution prepared by the same method and under the same conditions as in Example 1 to obtain a saline solution of the present invention having an effective chlorine concentration of 7 ppm. . Regarding this physiological saline, the primary irritation test of the ocular mucosa was carried out by a known method using Japanese native white rabbits (Kiyoko Shiba et al., "Strong Electrolyzed Water Handbook", page 51, Medical Information Company, Heisei (September 1, 2007). As a result, no change was observed in the rabbit instilled with the physiological saline, and it was confirmed that there was no damage to the conjunctiva, cornea and the like.

Example 7 A normal saline solution was added to and diluted with a saline solution prepared by the same method and under the same conditions as in Example 1 to obtain a saline solution of the present invention having an effective chlorine concentration of 2 ppm. . The obtained physiological saline was stored in a stainless steel washing tank having a length and width of 40 cm and a depth of 30 cm, and the stored physiological saline was circulated by a pump. A scalpel, kanshi, and tweezers, which have been washed with a detergent in advance, are placed in the washing tank in which the physiological saline is circulating in this manner.
Immersed for a minute and then pulled up. A bacterial test was performed under the same conditions as in Example 5, but no bacteria were detected.

[0035]

The physiological saline or various kinds of cleaning and disinfecting water of the present invention does not contain a bactericide, a preservative, etc., can be safely applied to the human body, and is suitable for medical practice. Since it itself has a bactericidal action, it can be widely used for disinfection. Further, the method for producing physiological saline according to the present invention can be easily prepared with a simple device, and the equipment investment cost and production cost are low.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) C02F 1/50 560 C02F 1/50 560F 1/76 1/76 A C25B 1/26 C25B 1/26 C 9 / 00 A61L 2/02 Z // A61L 2/02 C25B 9/00 D (72) Inventor Kiyoshi Suzuki 5-1-83 Higashihara, Zama-shi, Kanagawa Pref. Morinaga Milk Industry Co., Ltd. Analysis Center-(72) Inventor Toyohiko Doi 4-515 Tateno, Higashiyamato-shi, Tokyo Morinaga Dairy Products Co., Ltd.F-term (reference) 4C058 AA12 AA13 AA28 AA29 BB07 JJ07 JJ21 JJ23 JJ30 4D050 AA02 AA04 AB06 BB04 BD04 BD08 CA10 CA13 CA20 4D061 DA02 DA02 DB01 DB09 EA EB14 EB37 ED12 FA20 GA02 GA06 GA12 GA21 GA22 4K021 AB07 BA05 BC01 DA17 DC07

Claims (10)

[Claims] 1. A physiological saline having a bactericidal action obtained by adding a predetermined amount of sodium chloride to electrolyzed water obtained by electrolyzing an aqueous hydrochloric acid solution containing substantially no sodium chloride. 2. The physiological saline having a bactericidal action according to claim 1, wherein the electrolyzed water is electrolyzed by a non-diaphragm electrolytic cell. 3. The physiological saline having a bactericidal action according to claim 1, wherein the aqueous hydrochloric acid solution is prepared by adding hydrochloric acid to pure water. 4. The physiological saline having a bactericidal action according to claim 1, wherein the concentration of sodium chloride is 0.9% by weight. 5. A skin cleaning and disinfecting water comprising the physiological saline according to claim 1. 6. A disinfecting water for washing an affected part, comprising the physiological saline according to any one of claims 1 to 4. 7. A medical instrument cleaning / disinfecting water comprising the physiological saline according to any one of claims 1 to 4. 8. A dental cleaning and disinfecting water comprising the physiological saline according to any one of claims 1 to 4. 9. An ophthalmic cleaning / disinfecting water comprising the physiological saline according to claim 1. Description: 10. Hydrochloric acid is added to water containing substantially no sodium chloride, and the obtained hydrochloric acid-added water is passed through a non-diaphragm electric field tank to be electrolyzed. A method for producing physiological saline having a bactericidal action, characterized by adding sodium.