WO2010004699A1 - Agent d'élimination la mauvaise haleine et son procédé de production - Google Patents

Agent d'élimination la mauvaise haleine et son procédé de production Download PDF

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Publication number
WO2010004699A1
WO2010004699A1 PCT/JP2009/003003 JP2009003003W WO2010004699A1 WO 2010004699 A1 WO2010004699 A1 WO 2010004699A1 JP 2009003003 W JP2009003003 W JP 2009003003W WO 2010004699 A1 WO2010004699 A1 WO 2010004699A1
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bad breath
ppm
water
instead
producing
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PCT/JP2009/003003
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English (en)
Japanese (ja)
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野口宗則
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野口歯科医学研究所株式会社
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Priority to JP2010519628A priority Critical patent/JPWO2010004699A1/ja
Publication of WO2010004699A1 publication Critical patent/WO2010004699A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Definitions

  • the present invention relates to a bad breath suppressant for suppressing or improving bad breath and a method for producing the same.
  • VSC volatile sulfur compounds
  • Such volatile sulfur compounds are produced by the metabolism of anaerobic bacteria that inhabit the oral cavity.
  • High VSC production by bacteria such as Intermedia (Prevotella intermedia), Tanerella forcicensis, Campylobacter rectus, Treponema denticola (T.denticola), Fusobacterium nucleatum (Fusobacterium nucleatum) Therefore, a particularly strong odor is generated from the oral cavity of periodontal disease patients.
  • CHX chlorhexidine
  • CPC cetylpyridinium chloride
  • triclosan popidone iodine
  • benzethonium chloride and zinc chloride are often mixed in the mouthwash.
  • chlorhexidine has been confirmed to have a certain sterilizing action against bacteria in the oral cavity, it is effective only for bacteria, so that the tongue becomes black due to fungi grown by the fungal substitution phenomenon, so-called black hair tongue It has also been pointed out that it causes side effects called “causes” and causes allergies. In Japan, the concentration used is limited.
  • Cetylpyridinium chloride is contained in conventional mouthwashes and dentifrices, and although it has been confirmed to suppress plaque formation and improve gingivitis, it is sufficient for oral bacteria. As a result, there was a problem that the bad breath could not be sufficiently suppressed.
  • the fragrance has an effect of masking the bad breath component, since it does not sterilize the volatile sulfur compound (VSC), it does not substantially improve the bad breath.
  • VSC volatile sulfur compound
  • the present invention has been made in consideration of the above-described circumstances, and an object of the present invention is to provide a bad breath inhibitor capable of reliably suppressing bad breath without causing side effects and a method for producing the bad breath.
  • the bad breath suppressant according to the present invention has an effective chlorine concentration of 50 to 700 ppm, a pH of 6.3 to 8, and hypochlorous acid and hydrogen carbonate. It contains sodium.
  • the halitosis suppressor according to the present invention has an effective chlorine concentration of 201 to 700 ppm instead of 50 to 700 ppm.
  • the bad breath suppressant according to the present invention has an effective chlorine concentration of 400 to 700 ppm instead of 201 to 700 ppm.
  • the bad breath suppressant according to the present invention has a pH of 7 to 8 instead of 6.3 to 8.
  • the halitosis suppressor according to the present invention has an effective chlorine concentration of 500 to 700 ppm instead of 50 to 700 ppm, and a pH of 7 to 8 instead of 6.3 to 8. .
  • the bad breath odor suppressor according to the present invention has an effective chlorine concentration of 50 to 300 ppm instead of 50 to 700 ppm, and a pH of 7 to 8 instead of 6.3 to 8. .
  • the method for producing a halitosis inhibitor according to the present invention uses an aqueous solution to which sodium chloride and carbon dioxide are added as a stock solution, and the stock solution has an effective chlorine concentration of 50 to 700 ppm and a pH of Electrolysis is performed so that 6.3 to 8 is obtained and hypochlorous acid and sodium hydrogen carbonate are generated.
  • the method for producing a bad breath odor suppressor comprises adding the stock solution to water through a reverse osmosis membrane, adding sodium chloride to the passing water, and simultaneously with or before or after the sodium chloride addition step. This is produced by blowing or adding dry ice.
  • the method for producing the bad breath odor suppressor according to the present invention comprises adding the sodium chloride to the stock solution, pure water or distilled water, and blowing carbon dioxide gas or dry ice before or after the sodium chloride addition step. It is produced by adding.
  • the method for producing a bad breath odor suppressor according to the present invention is characterized in that the stock solution is passed through a reverse osmosis membrane with water, sodium chloride is added to the passing water, and the carbon dioxide partial pressure in contact with the passing water is reduced in the atmosphere It is produced by making it higher than the partial pressure.
  • the method for producing a bad breath suppressant according to the present invention comprises adding the sodium chloride to pure water or distilled water as the stock solution, and changing the partial pressure of carbon dioxide in contact with the pure water or distilled water to the partial pressure in the atmosphere. It is produced by making it higher.
  • the method for producing a halitosis suppressor according to the present invention is such that the effective chlorine concentration is 201 to 700 ppm instead of 50 to 700 ppm.
  • the method for producing a halitosis inhibitor according to the present invention is such that the effective chlorine concentration is 400 to 700 ppm instead of the 201 to 700 ppm.
  • the pH is changed to 7 to 8 instead of the above 6.3 to 8.
  • the effective chlorine concentration is set to 500 to 700 ppm instead of the 50 to 700 ppm, and the pH is set to 7 to 8 instead of the 6.3 to 8. Is.
  • the effective chlorine concentration is set to 50 to 300 ppm instead of 50 to 700 ppm, and the pH is set to 7 to 8 instead of 6.3 to 8. Is.
  • the present applicant has developed a sterilizing water for periodontal disease treatment using a high concentration of hypochlorous acid as a sterilizing component, and confirmed that it can kill periodontal pathogens in clinical trials (Patent Document 3), R & D was conducted focusing on whether such sterilized water could be used as a bad breath suppressant.
  • the volatile sulfur compounds that cause halitosis are produced when oral bacteria metabolize proteins such as cysteine and methionine present in saliva, deciduous epithelial cells, or food residues. In order to fundamentally suppress bad breath, it is essential to sterilize oral bacteria.
  • pathogenic bacteria are not protected as floating bacteria, but are protected by a biofilm made of exopolysaccharides produced by themselves, and with the biofilm, the body's body defense mechanisms and antibiotics are used. Prolonged growth slowly while blocking.
  • the present applicant made an aqueous solution to which sodium chloride (NaCl) and carbon dioxide were added as a stock solution.
  • the stock solution had an effective chlorine concentration of 201 to 700 ppm and a pH of 6 Obtain new knowledge that if electrolysis is performed to 3 to 8, not only hypochlorous acid (HClO) but also sodium hydrogen carbonate (NaHCO 3 ) can be newly generated and contained at a high concentration.
  • the bad breath odor suppressor according to the present invention it is possible to completely sterilize oral bacteria and thereby prevent volatile sulfur compounds from being produced in the oral cavity.
  • the bad breath intensity could be remarkably suppressed not only because the oral bacteria producing volatile sulfur compounds can be sterilized by the bad breath suppressor according to the present invention as described above, but also solid matter.
  • Volatile sulfur compounds adhering to the tongue and teeth are captured by sodium bicarbonate contained in the bad breath suppressant and discharged during gargle, and volatile sulfur compounds vaporized in the oral cavity are included in the bad breath suppressant This is probably because hypochlorous acid is oxidized and brominated free.
  • the substrate necessary for metabolism of oral bacteria is oxidized by hypochlorous acid contained in the bad breath suppressant.
  • hypochlorine is used for sites in the oral cavity excluding periodontal pockets, such as the surface of the crown and the root of the root, even if the effective chlorine concentration is less than 201 ppm. It has also been found that since there are relatively few organic substances that cause a decrease in acid concentration, oral bacteria living in the above-mentioned site can be sufficiently sterilized.
  • the bad breath suppressant according to the present invention can be used not only to weaken strong bad breath, but also to prevent bad breath deterioration.
  • the effective chlorine concentration is 50 to 300 ppm, the patient himself can Sufficient safety is ensured even in daily use, and it can be used at home.
  • forced dissolution of carbon dioxide means that the solubility of carbon dioxide is higher than the concentration at which it can be dissolved naturally (the solubility under the partial pressure of carbon dioxide present in the atmosphere).
  • the stock solution may be prepared by any one of the following methods (a) to (d). In any method, acid other than hydrochloric acid, acetic acid and other carbonic acid is used. Do not add at all. Therefore, the main solution composition condition is the amount of sodium chloride added.
  • the water that is a component of the stock solution in (a) and (c) can use well water, tap water, etc., and it is not necessary to use pure water.
  • the bad breath suppressant is contained in the oral cavity, and is contained for several seconds to several tens of seconds.
  • the oral malodor suppressant produces a volatile sulfur compound while destroying the biofilm and gradually losing bactericidal power due to oxidation of organic substances and other cells present in the surroundings. Sterilizes internal bacteria, mainly periodontal pathogens, in a short time and reliably.
  • the pH was adjusted to 6.3 to 8 because there was a concern about the decalcification of teeth at pH 6.3 or lower, and below pH 6, the concentration of H 2 CO 3 , HCO 3 ⁇ and CO 3 2 ⁇ The proportion of HCO 3 ⁇ in the rate becomes low, making it difficult to produce sodium bicarbonate that can destroy the biofilm.
  • the concentration of HClO in the concentration fractions of Cl 2 , HClO and ClO ⁇ This is because the abundance ratio decreases and it becomes difficult to generate a high concentration of hypochlorous acid that can sterilize bacteria, particularly caries pathogenic bacteria.
  • the pH is preferably set to 7 or more because lactic acid produced by cariogenic pathogenic bacteria can be neutralized to prevent the oral cavity from being acidified.
  • the reason why the effective chlorine concentration is set to 50 ppm or more is that sterilization is difficult even if it is less than 50 ppm even in the case of oral bacteria attached to the surface of the crown or the shallow part of the root.
  • Sterilizing over a long period of time may cause bacteremia by inducing hundreds of thousands of bacteria into the body (intravascular), leading to systemic disease, and within 30 seconds If possible, it must be killed within 10 seconds.
  • the concentration of 500 ppm or more is desirably set to a concentration of hypochlorous acid that can sterilize or lyse oral bacteria such as caries pathogens and periodontal pathogens even if the ratio of hypochlorous acid is low near pH 8. This is because it can be secured sufficiently.
  • the reason why the concentration is 700 ppm or less is that the concentration exceeding 700 ppm is an unnecessary concentration for sterilization and achievement of the above (i) to (iii).
  • the effective chlorine concentration when the effective chlorine concentration is set to 300 to 700 ppm, various oral bacteria, particularly periodontal pathogens and caries pathogens can be sterilized or lysed within about 30 seconds. Further, when the effective chlorine concentration is 400 to 700 ppm, sterilization or lysis can be performed within about 10 seconds.
  • the bad breath suppressant according to this embodiment includes hypochlorous acid (HClO) and sodium hydrogen carbonate (NaHCO 3 ), and the effective chlorine concentration is 201 to 700 ppm, preferably 400 to 700 ppm, and more preferably 500 to 700 ppm.
  • the pH is 6.3 or more and 8 or less, preferably 7 or more and 8 or less.
  • FIG. 1 shows an apparatus for producing a bad breath suppressant according to this embodiment.
  • the bad breath odor suppressor generating apparatus 51 includes a stock solution tank 3 for storing a stock solution 52, a stroke pump 4 connected to the stock solution tank, and a communication connection to the stroke pump. And a diluting water tank 8 in which the diluting water 57 is stored, and the tip of the discharging pipe 6 is stored in the diluting water tank 8.
  • the installation position of the dilution water tank 8 relative to the tip position of the discharge pipe 6 is relatively positioned so as to be equal to or lower than the water level of the dilution water 57.
  • the stock solution 52 is prepared by any of the methods described below, but no acid other than hydrochloric acid, acetic acid or other carbonic acid is added in any of the methods.
  • Diluent water 57 may be well water, tap water, pure water, or any other water, but the pH is appropriately selected so that the pH of the mouth odor suppressant to be produced is in the above-described range.
  • the generation apparatus 51 further includes a deaeration module 11 in which the water injection side is communicated with the secondary generation water 60 obtained by diluting the primary generation water with the dilution water 57 in the dilution water tank 8.
  • the deaeration module is adapted to remove dissolved oxygen from the secondary product water 60 by reducing the pressure by the vacuum pump 12, and to remove the tertiary product water from which the dissolved oxygen has been removed from the secondary product water 60 from the bad breath.
  • a tertiary product water tank 14 is stored as 63.
  • the tubes used in the generation device 51 or the electromagnetic valve provided as necessary may be deteriorated by oxidation with a high concentration of hypochlorous acid, so that it is desirable to form with fluorine.
  • the effective chlorine concentration of the tertiary product water is 201 to 700 ppm, desirably 400 to 700 ppm, more desirably 500 to 700 ppm.
  • the composition conditions of the stock solution 52 mainly the amount of sodium chloride added
  • the operating conditions during electrolysis eg voltage value and current value
  • the pH is 6.3 to 8, preferably 7 to 8.
  • the dilution conditions are determined, and the blended stock solution 52 is stored in the stock solution tank 3.
  • Sodium chloride is added, for example, 2 to 5% by mass.
  • the method for temporarily increasing the solubility of carbon dioxide can be further classified into either a method by blowing carbon dioxide or a method by adding dry ice.
  • temporary means that the partial pressure of carbon dioxide in contact with the solvent is equal to the partial pressure of carbon dioxide present in the atmosphere.
  • carbon dioxide is mixed at atmospheric pressure, Even when forced press-fitting is performed, the solubility of carbon dioxide decreases with time due to pressure equilibrium with the partial pressure of carbon dioxide contained in the air. In this case, it is necessary to perform electrolytic treatment promptly before the solubility of carbon dioxide decreases.
  • the water is passed through a reverse osmosis membrane, pure water or distilled water is used as a solvent, and the solvent is sealed in an airtight tank.
  • a method in which carbon dioxide is injected or carbon dioxide gas is blown into a solvent in an airtight tank or dry ice is added to the solvent can be employed.
  • the forced dissolution of carbon dioxide is made by selecting one of the following methods.
  • the water that passes through the reverse osmosis membrane may be of any property, but it is purified to some extent in the sense of reducing the burden on the reverse osmosis membrane and the water purifier using it, or reducing the amount of waste water as much as possible.
  • Water is desirable.
  • ground water, tap water, or commercially available mineral water (commercial water) can be used.
  • tap water is used as the water that passes through the reverse osmosis membrane.
  • the stock solution 52 is then weighed in an amount corresponding to one batch of bad breath suppressant and stored in the stock solution tank 3, and diluted water in an amount corresponding to one batch of bad breath suppressant.
  • 57 is stored in the dilution water tank 8.
  • the amount of the dilution water 57 corresponding to one batch of bad breath odor suppressor may be appropriately determined according to the dilution rate and the pH of the dilution water.
  • the stock solution 52 is sent to the electrolytic cell 5 by the stroke pump 4, and the electrolytic cell 5 is operated under predetermined operating conditions to electrolyze the stock solution 52.
  • the primary generated water generated in the electrolytic cell 5 is injected into the diluted water 57 previously stored in the diluted water tank 8 through the discharge pipe 6 connected to the electrolytic cell.
  • the installation position of the dilution water tank 8 is relatively positioned so that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 57 stored in the dilution water tank 8.
  • the primary product water is injected into the dilution water 57 through the discharge pipe 6 without coming into contact with air (outside air).
  • the primary product water is injected into the diluting water 57 weighed in advance in a so-called batch system, the primary product water is diluted with the dilution water unlike conventional mixing in the pipe. 57 is mixed homogeneously.
  • the tertiary product water from which dissolved gas, particularly dissolved oxygen is removed is generated, and this is used as the bad breath suppressor 63 in the tertiary product water tank 14.
  • the bad breath suppressant 63 is included in the oral cavity, for example, for several seconds to several tens of seconds.
  • sodium hydrogen carbonate contained in the bad breath suppressor 63 destroys the biofilm, while hypochlorous acid gradually loses its bactericidal power due to oxidation of organic substances and other bacterial cells present in the surroundings. It sterilizes oral bacteria that produce volatile sulfur compounds in a short time.
  • hypochlorous acid contained in the bad breath suppressor 63 oxidizes volatile sulfur compounds vaporized in the oral cavity to make no bromide, and sodium hydrogen carbonate contained in the bad breath suppressor 63. Captures volatile sulfur compounds adhering to the tongue and teeth as solids and substrates necessary for the metabolism of oral bacteria and excretes them during garnishing.
  • an aqueous solution to which sodium chloride and carbon dioxide are added is used as a stock solution, and the stock solution has an effective chlorine concentration of 201.
  • Electrolysis is performed so that the pH is 6.3-8, preferably 7-8, so that the biofilm can be destroyed at a high concentration so that the biofilm can be destroyed. It is possible to produce both sodium hydrogen carbonate and hypochlorous acid at a high concentration that can sterilize oral bacteria such as periodontal pathogens.
  • innovative action and effect that can sterilize or lyse and wash or remove volatile sulfur compounds in the oral cavity Unlikely to.
  • Fig. 2 is a graph showing the existing abundance ratio of available chlorine (extracted from "Water Purification Technology", published by Gihodo Publishing Co., Ltd.). As can be seen from the figure, conventionally, the abundance ratio of hypochlorous acid was drastically lowered at pH 7 or higher, and the abundance ratio was 20% at pH 8.
  • hypochlorous acid Since it is difficult to directly measure hypochlorous acid in available chlorine, further research and development is necessary. However, considering the fact that caries pathogens have been killed and the results of pH measurement, the pH should be 7-8. Even so, there is a high possibility that a sufficient concentration of hypochlorous acid has been produced.
  • hypochlorous acid can kill bacteria with sufficient bactericidal power in a pH range of 7 to 8, which has not been attracting attention in the past, and such pH range
  • This is a synergistic effect with the biofilm destroying action of sodium hydrogen carbonate, which has a high abundance ratio, and has an industrially significant effect that bacteria in the biofilm can be killed without removing the biofilm in advance. is there.
  • the killing of bacteria by the bad breath odor suppressor leads to a so-called lysis state in which cell walls are broken and internal proteins are denatured, and there is no risk that resistant bacteria appear.
  • the dilution water tank 8 is configured such that the tip position of the discharge pipe 6 is equal to or lower than the water level of the dilution water 57 stored in the dilution water tank 8.
  • the primary generation water is injected into the dilution water 57 in a non-contact state with air (outside air), and thus the mixing ratio of the stock solution 52 and the electrolytic cell 5 Even if chlorine gas is generated due to the operating conditions differing from the design values, the chlorine gas is changed to hypochlorous acid in diluted water 57 whose pH environment is close to neutral. At the same time, there is no concern of volatilization in the air as chlorine gas.
  • the primary product water generated in the electrolytic cell 5 is poured into the dilution water 57 measured in advance in a batch system, it is possible to perform homogeneous mixing unlike conventional mixing in piping. It becomes possible to adjust the pH of the secondary product water 60 and the effective chlorine concentration contained therein as designed values.
  • the dissolved gas is removed from the secondary produced water 60 to produce the tertiary produced water 63, which is used as the bad breath suppressant.
  • the foaming phenomenon can be prevented in advance, and the situation where bacteria in the oral cavity are sent into the body (in the blood vessel) can be prevented.
  • the dissolved gas in the secondary product water 60 is removed using the degassing module 11, but there is a concern that a foaming phenomenon may occur because the concentration of the dissolved gas in the secondary product water 60 is low. If not, the step of removing the dissolved gas may be omitted. In such a case, the secondary product water 60 serves as a bad breath suppressant.
  • FIG. 3 is a diagram showing a generating device 51a used when the dissolved gas removal step is omitted, and the degassing module 11, the vacuum pump 12, and the tertiary generated water tank 14 are omitted from the generating device 21.
  • the stock solution 52 and the dilution water 57 in an amount corresponding to one batch of bad breath suppressant are weighed and stored in the stock solution tank 3 and the dilution water tank 8 in advance.
  • stock solution 52 of an amount larger than one batch of bad breath suppressant for example, an amount corresponding to several batches
  • stock solution 52 corresponding to one batch of bad breath suppressant is stored.
  • a water level measuring means for measuring the amount of water can be appropriately configured by, for example, an ultrasonic sensor, an electrode type sensor or the like.
  • the stock solution is electrolyzed and then diluted to produce a halitosis inhibitor (post-dilution).
  • the stock solution is diluted, and then the diluted water is used. May be electrolyzed to obtain a halitosis suppressant (pre-dilution).
  • the dilution water tank 8 is omitted, and instead, a diluted stock solution tank for storing the diluted stock solution is separately provided between the stock solution tank 3 and the electrolytic cell 5. That's fine.
  • the effective chlorine concentration is set to 201 to 700 ppm.
  • the concentration of hypochlorous acid is reduced in the oral cavity excluding the periodontal pocket, for example, the surface of the crown surface or the shallow root portion. Since the organic matter is relatively small, even if the effective chlorine concentration is less than 201 ppm, it is possible to sufficiently sterilize oral bacteria that inhabit the site. That is, even when the effective chlorine concentration is 50 ppm or more and less than 201 ppm, it can be used as a bad breath suppressant.
  • the bad breath suppressant used mainly when bad breath is strong has been described, but the bad breath suppressant according to the present invention can be used not only to weaken strong bad breath but also to prevent bad breath deterioration. .
  • the effective chlorine concentration is 50 to 300 ppm, sufficient safety will be ensured even when patients themselves use it daily to prevent bad breath and can be used at home. It becomes.
  • the diluted stock solution was electrolyzed in an electrolytic cell to obtain a bad breath suppressant.
  • the electrolytic cell used was an electrolytic neutral water generating device sold by Sakai Engineering Co., Ltd. under the trade name “Epios Eco”.
  • a 40 ppm halitosis inhibitor was also prepared in the same procedure.
  • Table 1 shows the observation results with a microscope.
  • Test solution A By adding 5% (w / v) of dry ice to distilled water at atmospheric pressure and at room temperature, carbon dioxide constituting the dry ice is dissolved in the distilled water (saturated carbonated water). 0.6% (w / v) was dissolved.
  • Test solution B Saturated carbonated water, which is an intermediate product of test solution A, was diluted 5-fold with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
  • Test solution C Saturated carbonated water, which is an intermediate product of the test solution A, was diluted 10 times with distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
  • Test solution D By exposing distilled water to the atmosphere under atmospheric pressure and room temperature, carbon dioxide in the air was dissolved in the distilled water, and then 0.6% (w / v) of sodium chloride was dissolved.
  • Test method 4 L of the above stock solution was put into a non-membrane type electrolytic cell, and electrolysis was performed with a direct current of 2.8 A.
  • OralChroma Oral Chroma, registered trademark sold by Abi Medical Co., Ltd. was used.
  • the device can individually measure the concentration of three components of volatile sulfur compounds, hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. If only hydrogen sulfide is detected, there is a possibility of physiological bad breath. If only dimethyl sulfide is detected, it is highly likely that it is a bad breath caused by a visceral disease rather than an oral disease, and when two major causative substances such as hydrogen sulfide and methyl mercaptan are detected. It can be determined that there is a high possibility of bad breath caused by oral disease.

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Abstract

Selon l'invention, la mauvaise haleine est éliminée avec certitude sans provoquer aucun effet secondaire. Dans un agent d'élimination de la mauvaise haleine qui contient de l'acide hypochloreux et de l'hydrogénocarbonate de sodium, la concentration en chlore efficace est régulée à 201 à 700 ppm et la valeur du pH est régulée à 6,3 ou plus mais pas plus de 8, de préférence 7 ou plus mais pas plus de 8. Pour éliminer la mauvaise haleine à l'aide de l'agent décrit ci-dessus d'élimination de la mauvaise haleine, l'agent d'élimination de la mauvaise haleine est maintenu dans la cavité buccale et celle-ci est rincée avec ledit agent d'élimination de la mauvaise haleine, par exemple, pendant plusieurs secondes à plusieurs dizaines de secondes. Ainsi, l'hydrogénocarbonate de sodium contenu dans l'agent d'élimination de la mauvaise haleine rompt des biofilms tandis que l'acide hypochloreux tue de façon certaine les bactéries dans la cavité buccale (principalement des bactéries parodontales), qui produisent des composés de soufre volatils tels que le méthyl mercaptan, le sulfure d'hydrogène et le sulfure de diméthyle, sur une courte période de temps. De plus, les composés de soufre volatils décrits ci-dessus sont désodorisés en raison de l'effet oxydant de l'acide hypochloreux ou de l'effet désodorisant de l'hydrogénocarbonate de sodium contenu dans l'agent d'élimination de la mauvaise haleine.
PCT/JP2009/003003 2008-07-09 2009-06-30 Agent d'élimination la mauvaise haleine et son procédé de production WO2010004699A1 (fr)

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US9833471B1 (en) 2016-09-15 2017-12-05 Reoxcyn Discoveries Group, Inc. Hypochlorous acid-based hand sanitizer
US10471003B2 (en) 2016-05-18 2019-11-12 Reoxcyn, Llc Lubricant formulations
US10485827B2 (en) 2016-01-19 2019-11-26 Rdg Holdings, Inc. Topical eye serum compositions, methods or preparing, and methods of use
US10543230B2 (en) 2013-10-07 2020-01-28 Rdg Holding, Inc. Redox signaling gel formulation
US11583481B2 (en) 2017-01-16 2023-02-21 Reoxcyn, Llc Dentifrice formulations and methods of oral care
WO2023228443A1 (fr) 2022-05-24 2023-11-30 株式会社オクト Solution de destruction de biofilm et son procédé de production
US11857674B2 (en) 2016-05-18 2024-01-02 Reoxcyn, Llc Lubricant formulations

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