WO2006087996A1 - カルバペネム誘導体の製法およびその中間体結晶 - Google Patents
カルバペネム誘導体の製法およびその中間体結晶 Download PDFInfo
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- WO2006087996A1 WO2006087996A1 PCT/JP2006/302482 JP2006302482W WO2006087996A1 WO 2006087996 A1 WO2006087996 A1 WO 2006087996A1 JP 2006302482 W JP2006302482 W JP 2006302482W WO 2006087996 A1 WO2006087996 A1 WO 2006087996A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
Definitions
- the present invention relates to a method for producing a powerful rubapenem derivative and an intermediate crystal thereof.
- a pyrrolidylthio-powered rubapenem derivative (compound (II)) having a broad antibacterial spectrum is known as a useful antibiotic (Reference: Patent Document 1).
- the compound (I) of the present invention is a synthetic intermediate.
- R 1 is a carboxy protecting group: R 2 is an amino protecting group
- Patent Document 2 (Reference Example 1) describes the same reaction shown below, but the base used in the condensation reaction is also diisopropylethylamine (yield 54%).
- tertiary amines such as diisopropylpropylamine are generally used as bases for the second-position condensation reaction of force rubapenem. This is probably because tertiary amines are generally strongly basic and there is no hydrogen on the N atom, so side reactions are unlikely to occur! /.
- Patent Document 1 Japanese Patent Laid-Open No. 05-294970
- Patent Document 2 WO2004Z72073 Publication
- Patent Document 3 Japanese Patent Laid-Open No. 02-15080
- Patent Document 4 Japanese Patent Application Laid-Open No. 64-79180
- R is hydrogen or a hydroxy protecting group
- R 1 is a carboxy protecting group
- Ph is
- a compound (I), a pharmaceutically acceptable salt, a solvate or a crystal thereof is obtained by the method described in any one of 1 to 3 above, and then subjected to a deprotection reaction. And the formula:
- R 1 is a carboxy protecting group
- R 2 is an amino protecting group
- compound (I) can be produced in a short period of time based on yield. Also, a solvate crystal of compound (I) excellent in handling can be obtained.
- the present invention also provides a method for deprotection of Compound (I) in the presence of a Pd catalyst and an intermediate crystal. By using these production methods and crystals, a compound ( ⁇ ), a solvate thereof, or a crystal thereof, which is a carbapenem antibacterial agent, can be efficiently produced.
- FIG. 1 is a chart of a powder X-ray diffraction pattern of a benzyl alcohol solvate crystal of compound (I a) obtained in Example 1.
- FIG. 2 shows a peak value of a powder X-ray diffraction pattern of a benzyl alcohol solvate crystal of compound (Ia) obtained in Example 1.
- FIG. 3 is a chart of a powder X-ray diffraction pattern of a crystal of the compound (IV-a) obtained in Example 7.
- FIG. 4 is a chart of a powder X-ray diffraction pattern of a crystal of the compound (Va) obtained in Example 7.
- R is hydrogen or a hydroxy protecting group; R 1 is a carboxy protecting group; R 2 is an amino protecting group, Ph is a phenol
- R is hydrogen or a hydroxy protecting group
- R 1 is a carboxy protecting group
- R 2 is an amino protecting group
- Ph is a phenol
- the hydroxy protecting group is optionally deprotected to give compound (1), a pharmaceutically acceptable salt thereof, a solvate thereof or a crystal thereof.
- a secondary amine is used, more preferably a secondary amine having a relatively large steric hindrance.
- it is represented by NHR a R b , and R a and R b are each independently alkyl or phenol, and preferably R a and R b are the same.
- Alkyl is straight-chain or branched C1-C10, preferably C3-C7 alkyl, more preferably branched. More preferable examples of R a and R b include isopropyl, t-butyl, isobutyl, amyl, and file.
- diisopropylamine di-t-butylamine, diisobutylamine, diamylamine, and diphenylamine are more preferable, and dialkylamine (eg, diisopropylamine) is particularly preferable.
- reaction solvent examples include acetonitrile, dimethylformamide, methylene chloride, dimethyl sulfoxide, N dimethylacetamide and the like, and N dimethylacetamide is preferable.
- the reaction temperature is generally 40 ° C to room temperature, preferably about 20 to 0 ° C.
- the reaction time is usually several tens of minutes to several tens of hours, preferably 1 to 5 hours.
- an inorganic base salt eg, sodium
- Al metal salts such as salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; ammonium salts; organic base salts (eg, triethylamine salt, pyridine salt, picoline salt, ethanolamine salt, triethanol salt) Amine salts, dicyclohexylamine, ⁇ , ⁇ '-dibenzylethylenediamine salts); inorganic acid addition salts such as hydrochloride, hydrobromide, sulfate, phosphate; formate, acetate, trifluoro Organic acid addition salts such as acetate, maleate, tartrate, methanesulfonate, benzenesulfonate; basic amino such as arginine, aspartic acid, glutamic acid And salts with acid or acidic
- hydroxy protecting group represented by R various hydroxy protecting groups that can be generally used in the field of ⁇ -ratata antibacterial agents can be used. Specific examples thereof include trialkylsilyl (the alkyl is preferably C1-C6, eg, trimethylsilyl, triethylsilyl, tert-butyldimethylsilyl, triisopropylpropylsilyl, dimethylhexylsilyl, tert-butyldiphenylsilyl), substituted.
- trialkylsilyl the alkyl is preferably C1-C6, eg, trimethylsilyl, triethylsilyl, tert-butyldimethylsilyl, triisopropylpropylsilyl, dimethylhexylsilyl, tert-butyldiphenylsilyl
- hydroxy protecting groups can be deprotected after the reaction, if desired, by methods well known to those skilled in the art. Further, it may be a protecting group that is automatically removed during the coupling reaction or in the post-treatment (eg, extraction, washing) stage. For example, trimethylsilyl and the like are eliminated by acid in the extraction operation after the reaction.
- the carboxy protecting group represented by R 1 includes lower alkyl (eg, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, pentyl, hexyl), lower alkanoyloxy (lower) alkyl (eg, Acetoxymethyl, propio-loxymethyl, butyryloxymethyl, valeryloxymethyl, bivalyloxymethyl, hexanoloxymethyl), lower alkanesulfo-loxy (lower) alkyl (eg 2-mesylethyl), mono (or di or Tri) halo (lower) alkyl (eg, 2-iodoethyl, 2,2,2-trichloroethyl), lower alkoxycarboxoxy (lower) alkyl (eg, methoxycarbonyloxymethyl, ethoxycarbonyloxymethyl, propoxycarbonyloxyme) Chill, tertiary butoxy Rub
- R 1 the advantage of using this production method in the case of a protective group of a relatively electrophilic type is great.
- lower alkyl eg, bur, aryl
- Lower alkyl eg, (substituted) aryl, (lower) alkyl, or (substituted) aryl.
- it is a protecting group that is difficult to be removed during the coupling reaction, and particularly preferred is aryl (one CH 2 CH ⁇ CH 2).
- Examples of the amino protecting group represented by R 2 include an aliphatic acyl group derived from carboxylic acid, carbonic acid, sulfonic acid and carbamic acid, and an aliphatic acyl group substituted with an aromatic group.
- Aliphatic acyl groups are saturated or unsaturated acyclic or cyclic acyl groups, such as, for example, lower alkanol groups such as formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, bivaloyl, hexanoyl and the like.
- Alkanoyl groups such as mesyl, ethylsulfol, propylsulfol, isopropylsulfol, butinolesnorehoninore, isobutinoresnorehoninore, pentinoresnorehoninore, hexinoresnorephonyl, etc.
- Alkylsulfol groups such as lower alkylsulfol groups, rubamoyl groups such as N-alkyl rubamoyl groups such as methylcarbamoyl, ethylcarbamoyl, etc., such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl , Tertiary butoxy Alkoxycarbon groups such as lower alkoxy carbo groups such as rubols, for example, alkke groups such as lower alkoxy carboxy groups such as buroxy carboxy and aralkyl carboxylic groups.
- Alkoxyl groups such as alkoxyl groups such as lower alkenyl groups such as acryloyl, methacryloyl, crotonol, etc.
- Cyclo (lower) alkanecarbox such as cyclopropanecarbol, cyclopentanecarbol, cyclohexanecarbol etc.
- cycloalkane carbo yl group such as -l group.
- aliphatic acyl group substituted with an aromatic group examples include aralkoxycarbons such as vinyl (lower) alkoxycarbonyl groups such as benzyloxycarbol and phenoxycarboxyl. Group. These acyl groups may be further substituted with one or more suitable substituents such as -tro group. Preferred acyl groups having such a substituent include, for example, -troayloxycarbol and the like. Examples include a larcocarboxyl group.
- the amino protecting group is preferably a protecting group which is not easily eliminated during the coupling reaction, and particularly preferably an alkoxycarboxyl group (eg, COOCH CH ⁇ CH 3).
- Compound (Ia) can be crystallized from an alcohol solvent.
- the alcohol is preferably substituted and is benzyl alcohol, and the alcohol solvate crystals are obtained.
- substituent of the benzyl alcohol which may be substituted, lower alkyl, preferably C1-C4 alkyl (eg, methyl, ethyl, propyl), lower alkoxy (eg, methoxy, ethoxy, propoxy), Halogen (eg: F, Cl, Br), optionally substituted amino (example of substituent: lower alkyl), nitro, silane-containing OH, etc. are exemplified, and the substitution position is either ortho, meta or para. Good.
- a benzyl alcohol solvate crystal is preferably obtained.
- the content of benzyl alcohol in the benzyl alcohol solvate crystal is 0.1 to 5 molar equivalents, preferably 0.5 to 2 molar equivalents, more preferably 1 molar equivalent, relative to compound (Ia). .
- the benzyl alcohol solvate crystal preferably exhibits the pattern of FIG. 1 in powder X-ray diffraction.
- the benzyl alcohol solvate crystal preferably has a main peak at least in the vicinity shown below in the powder X-ray diffraction pattern.
- the interplanar spacing d value is selected from the main peaks having a high relative intensity among the X-ray peaks, and the crystal structure is not necessarily limited only by these values. That is, peaks other than these may be included. In general, when a crystal is measured by X-ray analysis, the peak may cause some measurement error due to the measuring instrument, measurement conditions, presence of attached solvent, and the like. For example, a measurement error of about ⁇ 0.2 occurs as the value of surface separation d In some cases, even if very precise equipment is used, a measurement error of about ⁇ 0.01 to 0.1 may occur. Therefore, some errors should be taken into account in identifying the crystal structure, and all crystals characterized by X-ray patterns substantially similar to those described above are within the scope of the present invention.
- the benzyl alcohol solvate crystal is prepared from the compound (I a)
- it is preferable to dissolve the compound (I a) or a solvate thereof in a soluble solvent It can be obtained by stirring for several hours at room temperature, allowing to stand at 0 ° C to room temperature for several hours to several days, and then filtering and drying by a conventional method. Also. After dissolving the compound (Ia) or its solvate in a large amount of solvent, the solvent is once distilled off to obtain a concentrated solution. To this, benzyl alcohol and other organic solvent as required are added, As described above, stirring, filtration, drying and the like may be performed.
- Examples of the solvent include the following soluble solvents, insoluble solvents and mixed solutions thereof.
- Soluble solvents include methanol, ethanol, ethylene glycol, methoxyethanol, glycerol, propylene glycol and other alcohols, dioxane, tetrahydrofuran, dimethoxyethane, and other ethers, acetone, methyl ethyl ketone, methyl isobutyl ketone, and other ketones.
- Esters such as methyl formate, ethyl acetate, propyl formate, methyl acetate, ethyl acetate, propyl acetate, butyl acetate, methyl propionate, ethyl propionate, dichloromethane, chloroform, Organic halogenated hydrocarbons such as carbon tetrachloride, 1,2-dichloroethane, trichloroethane, black benzene and dichlorobenzene, -tolyls such as acetonitrile and propio-tolyl, dimethyl Fuorumuamido, dimethyl sulfoxide, N- methylpyrrolidone, quinoline, pyridine, and the like can be used Toryechiruamin. These solvents may be used alone or in combination of two or more. It can also be used by mixing water. Preferred is ethyl acetate.
- insoluble solvents examples include alcohols such as 2-propanol, 2-pentanol, 1 pentanol, tamyl alcohol, 1 propanol, n propanol, t-butanol, isobutanol, n-butanol, cyclohexanol, and benzyl alcohol.
- Ethers such as ethinoreethenole, isopropinoleetenore, dibutinoleethenole, ethinoreisoaminolethele, ethylphenol ether, n pentane, n-hexane, n-heptane, n octane, n Hydrocarbons such as decane, cyclohexane, methylcyclohexane, toluene, benzene, ethylbenzene, tamen, cymene, and xylene can be used. These solvents may be used alone or in combination of two or more.
- the use ratio of the soluble solvent and the insoluble solvent is usually 1: 0 to 1: 1000, preferably 1: 0.1 to 1: 100, particularly preferably 1: 1 to 1:50 in weight ratio, or Usually, 0: 1 to 1000: 1, preferably 0.1: 1 to 100: 1, particularly preferably 1: 1 to 50: 1.
- ethyl acetate and benzyl alcohol are used in a ratio of 1: 1 to 5.
- the benzyl alcohol solvate crystal of compound (Ia) has very good crystallinity, as is clear from the clarity of its X-ray peak. Therefore, when compound (Ia) is synthesized by a 2-position condensation reaction and isolated as a benzyl alcohol hydrate crystal, the desired product is obtained with high yield and high purity. Moreover, the handleability is good and the storage stability is high. Therefore, it is very useful as an intermediate for the synthesis of compound (ii), a carbapenem antibacterial agent.
- the reaction extract is preferably washed, evaporated, and dried, as described above.
- Crystallization may be achieved by dissolving in a soluble solvent and calorifying benzyl alcohol and optionally other insoluble solvents.
- benzyl alcohol solvate crystals of the compound (Ia) separately prepared as required may be added as seed crystals.
- compound (1) a pharmaceutically acceptable salt thereof, a solvate thereof or a crystal thereof, preferably a benzyl alcohol solvate crystal of compound (Ia), to a deprotection reaction,
- the compound (ii), its pharmaceutically acceptable salt, its solvate, or crystal thereof, which is the antibacterial agent disclosed in Japanese Patent No. 294970, is obtained.
- the deprotection reaction is performed according to methods well known to those skilled in the art.
- a noble metal catalyst such as a nickel catalyst, a cobalt catalyst, an iron catalyst, a copper catalyst, a platinum catalyst and a palladium catalyst is used.
- Palladium catalyst and nickel catalyst are preferably used. More preferable are tetrakis (triphenylphosphine) palladium, acetic acid (triphenylphosphine) palladium, and acetic acid (triethylphosphite) palladium.
- An additive preferably triphenylphosphine or the like
- a reducing agent for reducing and removing the protecting group and a nucleophilic reagent are added to the palladium catalyst.
- the reducing agent include hydrogen, metal hydride, and the like, and preferably hydrogenated tri-n-butyltin.
- nucleophiles include carboxylates (eg, sodium 2-ethylhexanoate), 1,3-dicarboxyl compounds (eg, Meldrum's acid, dimedone and malonic acid esters), secondary amines (eg, Jetylamine, etc.) and aromatic amines.
- a combination of a palladium catalyst (eg, tetrakis (triphenylphosphine) palladium) and an aromatic amine (eg, Ryoji phosphorus derivative) is more preferable as a deprotection reagent.
- the ar phosphorus derivatives include: arline, N-methylarine, N-ethylaniline, ⁇ , ⁇ -dimethylaniline, 0—, m—or ⁇ —toluidine, 0—, m— or p-amino-idine.
- N-ethylaline is particularly preferable.
- N-ethylaline e.g., less than 0.01 molar equivalent to the compound (I), preferably 0.
- the deprotection reaction proceeds at a high yield even at 005 monorequivalents or less, more preferably from 003 to 0.001 monoequivalents.
- the generation rate of by-products derived from the protecting group and the aniline reagent is low, and the handling operation of the compound (II) deposited after deprotection is also good, which is suitable as a mass production method.
- the amount of the aromatic amine (eg, a phosphorus derivative) to be used is 1 to 20 mole equivalents, preferably 5 to 15 equivalents, relative to Compound (I).
- Compound (1) a pharmaceutically acceptable salt thereof, a solvate thereof or a crystal thereof
- a nuclear reagent is added to the solvent and the reaction system (eg, reaction mixture and vessel) is preferably filled with nitrogen.
- the reaction temperature is about 20-50 ° C, preferably in the range of 0-30 ° C.
- the reaction time is usually several minutes and several tens of hours, preferably in the range of 1 to 3 hours.
- the present invention further provides the crystals of compounds (IV-a) and (V-a), which are synthetic intermediates of compound (Ia).
- the crystals of compound (IV-a) may be solvates (eg, hydrates, alcohol solvates)!
- the crystals of compound (Va) may be solvates (eg hydrates, alcohol solvates).
- the crystals of compound (IV-a) are preferred as shown in Examples below.
- an acid more preferably with an inorganic acid (e.g. hydrochloric acid)
- the reaction solution is adjusted to pH with an alkali (preferably 2 to 3) and precipitated, then dried and concentrated by a conventional method, and organic It can be crystallized from a solvent (preferably an ethyl acetate-toluene system).
- H NSO NHBoc is added to the compound (VI-a).
- a radical trapping agent may be preferably used in combination.
- An example of the radical trapping agent is dibutylhydroxytoluene.
- a 2-propanol hydrate crystal (3.340 g, equivalent to 3.137 g in solvent-free equivalent) of the compound (Ia) described in WO2004Z72073 is dissolved in ethyl acetate (67 ml), and then ethyl acetate and isopropanol are dissolved.
- Ethyl acetate (3.14 ml), benzyl alcohol (3.14 ml), and toluene (12.55 ml) were added thereto, and the mixture was stirred at room temperature for 2 hours and then at 5 ° C for 1 hour.
- Powder X-ray diffraction The chart is shown in Fig. 1 and the peak value is shown in Fig. 2.
- Amorphous and powdery compound (I a) (100 mg) was dissolved in ethyl acetate (0.1 ml), benzyl alcohol (0.3 ml) was added and stirred at room temperature for 1 hour, then 5 ° C was left for 2 days. The precipitated crystals were separated by filtration and air-dried to obtain a benzyl alcohol solvate crystal (79 mg) of compound (Ia) showing substantially the same powder X-ray pattern as in Example 1.
- Compound (I a) (however, using isopropyl alcohol hydrate crystals) 500 mg is dissolved in 2 ml of tetrahydrofuran (THF), 10 equivalents of N-ethylaline, 2 ml of THF and 1 ml of H 0 in this order.
- THF tetrahydrofuran
- Example 6 The reaction of Example 6 was carried out in the same manner using aline instead of N-ethylaline (provided that the solvent used was THF (12V) monohydrate (2V)). As shown below, when the amount of Pd catalyst used was reduced, a large amount of by-products were generated and the production rate of compound (II) was significantly reduced.
- Fig. 4 shows the powder X-ray diffraction data.
- the peak with peak number 23 is the peak derived from the aluminum used in the measurement.
- Figure 3 shows the powder X-ray diffraction data.
- the peak with peak number 20 is the peak derived from the aluminum used in the measurement.
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Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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CN2006800048907A CN101119997B (zh) | 2005-02-15 | 2006-02-14 | 碳青霉烯衍生物的制备方法及其中间体结晶 |
EP20060713624 EP1852436A4 (en) | 2005-02-15 | 2006-02-14 | PROCESS FOR PRODUCING CARBAPENEME DERIVATIVE AND CRYSTALLINE INTERMEDIATE THEREOF |
CA2596951A CA2596951C (en) | 2005-02-15 | 2006-02-14 | Process for production of carbapenem derivative and crystalline intermediate therefor |
JP2007503647A JP5019389B2 (ja) | 2005-02-15 | 2006-02-14 | カルバペネム誘導体の製法およびその中間体結晶 |
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JP2005-037088 | 2005-02-15 | ||
JP2005037088 | 2005-02-15 | ||
JP2005193257 | 2005-07-01 | ||
JP2005-193257 | 2005-07-01 |
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WO2006087996A1 true WO2006087996A1 (ja) | 2006-08-24 |
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PCT/JP2006/302482 WO2006087996A1 (ja) | 2005-02-15 | 2006-02-14 | カルバペネム誘導体の製法およびその中間体結晶 |
Country Status (7)
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EP (1) | EP1852436A4 (ja) |
JP (1) | JP5019389B2 (ja) |
KR (1) | KR20070104594A (ja) |
CN (1) | CN101119997B (ja) |
CA (1) | CA2596951C (ja) |
TW (1) | TWI393721B (ja) |
WO (1) | WO2006087996A1 (ja) |
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CN101747251B (zh) * | 2008-11-28 | 2013-01-16 | 上海医药工业研究院 | 一种多尼培南的中间体的结晶及其制备方法 |
EP2401278A4 (en) * | 2009-02-26 | 2012-07-04 | Orchid Chemicals & Pharm Ltd | IMPROVED PROCESS FOR THE PREPARATION OF A CARBAPENEM ANTIBIOTICS |
US8822445B2 (en) * | 2010-06-03 | 2014-09-02 | Xuanzhu Pharma Co., Ltd. | Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof |
WO2015167148A1 (ko) | 2014-04-28 | 2015-11-05 | 제이더블유중외제약 주식회사 | 도리페넴의 신규한 결정 및 이의 제조방법 |
Citations (3)
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---|---|---|---|---|
JPH05294970A (ja) * | 1991-08-20 | 1993-11-09 | Shionogi & Co Ltd | ピロリジルチオカルバペネム誘導体 |
JP2003026680A (ja) * | 2001-05-10 | 2003-01-29 | Shionogi & Co Ltd | アセチルチオピロリジン誘導体の製法 |
WO2004072073A1 (ja) * | 2003-02-14 | 2004-08-26 | Shionogi & Co., Ltd. | カルバペネム合成中間体の結晶 |
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US5539102A (en) * | 1992-02-21 | 1996-07-23 | Shionogi Seiyaku Kabushiki Kaisha | Production method for sulfamide |
US5872250A (en) | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
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2006
- 2006-02-14 EP EP20060713624 patent/EP1852436A4/en not_active Withdrawn
- 2006-02-14 TW TW095104814A patent/TWI393721B/zh active
- 2006-02-14 CN CN2006800048907A patent/CN101119997B/zh not_active Expired - Fee Related
- 2006-02-14 JP JP2007503647A patent/JP5019389B2/ja not_active Expired - Fee Related
- 2006-02-14 CA CA2596951A patent/CA2596951C/en not_active Expired - Fee Related
- 2006-02-14 KR KR1020077018449A patent/KR20070104594A/ko active Search and Examination
- 2006-02-14 WO PCT/JP2006/302482 patent/WO2006087996A1/ja active Application Filing
Patent Citations (3)
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Also Published As
Publication number | Publication date |
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EP1852436A1 (en) | 2007-11-07 |
KR20070104594A (ko) | 2007-10-26 |
CN101119997B (zh) | 2011-06-22 |
CN101119997A (zh) | 2008-02-06 |
TW200639175A (en) | 2006-11-16 |
JP5019389B2 (ja) | 2012-09-05 |
TWI393721B (zh) | 2013-04-21 |
EP1852436A4 (en) | 2010-02-24 |
CA2596951C (en) | 2013-11-05 |
JPWO2006087996A1 (ja) | 2008-07-03 |
CA2596951A1 (en) | 2006-08-24 |
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