WO2006006282A1

WO2006006282A1 - Sedative composition

Info

Publication number: WO2006006282A1
Application number: PCT/JP2005/006390
Authority: WO
Inventors: Tsuyoshi Sakamoto
Original assignee: Kobayashi Pharmaceutical Co., Ltd.
Priority date: 2004-09-30
Filing date: 2005-03-31
Publication date: 2006-01-19
Also published as: JP2006104073A

Abstract

[PROBLEMS] To provide a sedative composition which is highly effective in tranquilizing the mind. [MEANS FOR SOLVING PROBLEMS] A distilled water obtained by the steam distillation of lavender is excellent in the function of tranquilizing the mind and the function of inducing a good sleep. The distilled water is used to prepare a sedative composition.

Description

Specification

Sedative composition

Technical field

[0001] The present invention relates to a sedative composition. More specifically, the present invention relates to a sedative composition having a sedative effect.

Background art

[0002] In recent years, aroma therapy using various plant-derived essential oil components has attracted attention as a means of reducing the mental adverse effects of stress and the like and calming the mind. In particular, it has been found that the essential oil component of Lavender has the effect of calming the mind and inducing sleep (for example, see Patent Document 1), and the essential oil component of Lavender is aimed at calming the spirit. It is often used for fresh air fresheners.

However, in recent years, as aromatherapy has been in the limelight, an aromatic component that has a more excellent sedative effect is required, and conventional essential oil components that are known to have a sedative effect satisfy consumer demands. I can't do that. Until now, most of the aromatic components having sedative activity are essential oil components, and water-soluble fragrance components that exhibit excellent sedative activity are almost known.

[0004] By the way, when producing essential oil by steam distillation of lavender, the water-soluble fraction (steam-distilled water) produced as a secondary component is not known for its characteristics and effective usage. It is completely known for its sedative and restfulness.

Patent Document 1: Japanese Patent Laid-Open No. 11-343497

Disclosure of the invention

Problems to be solved by the invention

[0005] Therefore, an object of the present invention is to provide a composition for sedation that is excellent in the action of calming the mind!

Means for solving the problem

[0006] The present inventors diligently studied to solve the above-mentioned problems. As a result, steam-distilled water obtained by steam-distilling lavender induces a soothing action and sleep. It was found that it is excellent in action. The present invention has been developed based on further knowledge and further studies.

[0007] That is, the present invention provides the following inventions:

Item 1. A sedative composition containing lavender steam distilled water.

Item 2. The sedative composition according to Item 1, wherein the lavender steam-distilled water is obtained from the above-ground part of the lavender or the whole plant power.

Item 3. The sedative composition according to Item 1 or 2, wherein the lavender is Okamurasaki or an improved variety thereof.

[0008] The present invention is described in detail below. In the present invention, the “sedative composition” is used for calming, relaxing, or inducing a sleep of a human or animal.

[0009] The sedative composition of the present invention is characterized by containing lavender steam distilled water.

[0010] Lavender is a plant species belonging to the family Labiatae and Lavandula, and is an authentic lavender (scientific name; Lavandula).

L. officinalis ^ vera), Sno 《Icraventer (scientific name; L.spica), Stokes (scientific name; L.stoechas), Labandin (scientific name; L.hybrida) And so on. In the present invention, the type of lavender to be used is not particularly limited. Particularly preferred examples include various varieties such as Okamurasaki, Hanamoiwa, dark purple early bloom, and Yodei, and most preferred are Okamurasaki or improved varieties thereof, particularly those from Hokkaido, Japan. Lavender may be wild or cultivated.

[0011] As a raw material of steam distilled water of lavender, lavender flowers, spikes, fruits, pericarp, stems, leaves, branches, branches and leaves, stems, crusts, rhizomes, root barks, seeds, either alone or in combination You can also use lavender whole plants. The raw material of lavender steam-distilled water is preferably the above-ground part (whole plant excluding roots) or whole grass. By using these, the sedative effect and the sleep-inducing effect are remarkably exhibited.

[0012] Lavender steam distilled water, 0.6 to 2 parts by weight of water with respect to 1 part by weight of lavender, Preferably, it is prepared by performing steam distillation using 0.8 to 1 part by weight and collecting the aqueous phase of the collected distillate. The method for steam distillation is not particularly limited, but a pressurized steam distillation method is preferable.

[0013] The sedative composition of the present invention may be composed only of lavender steam distilled water, but contains other components such as a carrier, a substrate or an additive depending on the form of use. You may do it. The blending ratio of lavender steam distilled water in the sedation composition of the present invention varies depending on the use form of the composition, expected effects, etc., and cannot be specified uniformly, but as an example, Lavender water-distilled water is 0.01 to 100% by weight relative to the total weight. / ₀ , preferably 1 to: L00 wt%, more preferably 10 to 100 wt%.

[0014] Regarding the shape of the sedative composition of the present invention, it may be in any form such as liquid, gel, solid, jewel, paste, and sheet. What is necessary is just to set suitably according to the intended purpose.

[0015] The sedative composition of the present invention can be used by supporting a nonwoven fabric, a sheet, a film, or the like as a carrier (holding body). Thus, the carrier material for carrying the sedative composition of the present invention is not particularly limited. For example, natural fibers such as pulp, cotton, wool, hemp and silk; polypropylene, polyethylene, polyamide, polyethylene terephthalate, Synthetic fibers such as ribylene terephthalate, polysulfone, rayon, methacrylic acid resin, and glass fiber; and porous materials such as zeolite, talc, white carbon, diatomaceous earth, lime, silica gel, and activated charcoal.

[0016] The form of the sedative composition of the present invention is not limited as long as lavender steam distilled water is volatilized and aroma is exhibited.

[0017] As an example of the form of the sedative composition of the present invention, one used in a mode in which lavender steam-distilled water is evaporated or volatilized in an indoor space can be mentioned. Specific examples of such a soothing composition include products such as aroma candles and indoor fragrances. By using the sedative yarn and composition in this form, the steam distilled water of lavender is evaporated in the space, and the effect of calming the mind can be given to the person or pet existing in the space. [0018] Further, as other forms of the sedative composition of the present invention, for example, cosmetic forms such as lotion, emulsion, cream, ointment, lotion, oil, knock, foundation, lipstick, scarlet, bath preparation Is mentioned. Thus, by using the sedative composition of the present invention as a cosmetic, a sedative effect of the mind can be obtained through the use of the cosmetic. Further, the sedative composition of the present invention may be in the form of an external preparation for skin (external medicine or quasi drug).

[0019] In addition to the above, the sedative composition of the present invention includes, for example, bedding such as futons and pillows; clothing; curtains; doors; screen doors; Those used in an embodiment in which steam distilled water is sprayed or applied. By using the sedative composition in this form, the components of the lavender steam-distilled water are volatilized from the daily necessities to which the sedative composition is adhered, thereby producing an excellent sedative effect. Examples of such forms include spray preparations, aerosol preparations, liquid, gel or cream preparations, and those obtained by impregnating them with a nonwoven fabric or the like.

The invention's effect

The sedative composition of the present invention uses lavender steam distilled water, which is a natural component, and has high safety, so that it is volatilized in the space and applied or sprayed to daily necessities. It can be applied directly to human skin as a simple cosmetic.

[0021] Further, since the sedative composition of the present invention has an excellent sedative effect in addition to an excellent sedative effect, it is also useful as a composition for inducing sleep or a composition for sedative sleep. Suitable for people with insomnia and poor sleep.

[0022] In particular, steam-distilled water from which the above-ground part of lavender or the whole plant power can be obtained has a particularly prominent sleep / sedation effect, and a sedative composition containing the steam-distilled water is extremely useful.

Brief Description of Drawings

[0023] FIG. 1 is a diagram showing the results (chromatograph) of lavender steam distilled water obtained in Example 1 analyzed by gas chromatography.

[Figure 2] Shows the results (chromatograph) of gas chromatographic analysis of lavender essential oil It is a figure.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

Example 1 Preparation of Lavender Steam Distilled Water

About 60 kg of lavender (Okamurasaki) above ground (whole plant excluding roots) was subjected to pressurized steam distillation using about 50 kg of water to produce a distillate containing 36 kg of water phase and 0.36 kg of oil phase. The aqueous phase was recovered from the distillate to obtain lavender steam distilled water.

[0025] Test Example 1

With the paper (40 mm long, 40 mm wide, 5 mm thick) impregnated with about 4 g of lavender steam distilled water obtained in Example 1 installed on the monitor of a desktop personal computer at the office desk, Three subjects (Subjects 1 to 3) Force The task of inputting simple numerical data into a computer was performed for 15 minutes, and the accuracy of the task (input correct answer rate) and worker fatigue were evaluated. As a comparison, one 30-year-old subject (subject 4) used water instead of the lavender's steam distilled water to perform the same personal computer input work as above. We evaluated the feasibility (input correct answer rate) and worker fatigue. At the same time the day before the above test, subjects 1 to 4 performed the same personal computer input work using water instead of lavender steam distilled water, and the result was used as a control console. . Specifically, the evaluation was performed according to the following criteria.

Work

A: Input accuracy rate is clearly improved compared to the previous day

B: Input accuracy rate is not much different from the previous day

C: Input accuracy rate clearly decreased compared to the previous day

Feeling of labor

A: Fatigue during and after work is less than the previous day

B: Fatigue during and after work is the same as the previous day

C: Fatigue during and after work is higher than the previous day The results obtained are shown in Table 1. As a result, it was confirmed that in the environment where the sedative composition of the present invention is volatilized, an accurate operation was performed and there was little fatigue after the operation. From the above results, it was suggested that the sedative composition of the present invention has an excellent sedative effect of the spirit, and the composition is volatilized to provide a relaxing effect in the environment.

[0026] [Table 1]

[0027] Test Example 2

We also randomly selected three adults with poor sleep or adult insomnia. 350 ml of the lavender steam distilled water obtained in Example 1 is put in a known volatile liquid volatilization container, this is placed at the bedside, and the above three subjects sleep at this state. The effect of the composition on sleep was evaluated. The evaluation was performed according to the following evaluation criteria for (1) falling asleep, (2) depth of sleep, (3) awakening during sleep, and (4) state of awakening.

A: V, better than Tsum

B: V, no change compared to Tsumo!

C: worse than usual

Table 2 shows the results obtained. As a result, it was confirmed that the sedative composition of the present invention has an excellent sleep promoting effect and a sleep inducing effect.

[0028] [Table 2] Rating ABC

(1) Sleeping 3 0 0

(2) Sleep depth 3 0 0

(3) Awakening during sleep 3 0 0

(4) Awakening state 3 0 0

The numbers in the table indicate the number of people.

[0029] Test Example 3

We also randomly selected three adults with poor sleep or adult insomnia. 50 ml of the lavender steam-distilled water obtained in Example 1 was added to a water bath containing about 200 L of hot water. The above three subjects soaked in this bathtub for about 5 minutes and then went to sleep within 30 minutes. The sleepiness at that time was evaluated according to the following evaluation criteria.

A: V, better than Tsum

B: V, no change compared to Tsumo!

C: worse than usual

The results obtained are shown in Table 3. As a result, even when the sedative composition of the present invention was used as a bath agent, it was confirmed that, as with the result of Test Example 2, sleep was improved and an excellent sleep promoting effect and sleep inducing effect were obtained. It was.

[0030] [Table 3]

Evaluation A — B — C—

(1) Sleeping 3 0 0

The numbers in the table indicate the number of people.

[0031] Participant Example Composition Analysis

The lavender steam distilled water and lavender essential oil obtained in Example 1 were subjected to component analysis by gas chromatography. As the lavender essential oil to be analyzed, the oil phase in which the distillate power produced by steam distillation was recovered in Example 1 was used. For the analysis, 47.5 g of lavender steam distilled water obtained in Example 1 was mixed with 2.5 g of hexane, and the lavender essential oil diluted to 1% by weight with methanol was used as samples. . The analysis conditions are as follows. <Analysis conditions>

Gas chromatograph

Hewlett Packard

HP6890 series

Column

DB-5MS

Length 30m

ID 0.25 mm

Film thickness 0.

The oven

Initial temperature 50 ° C 7 minutes

Heated up to 100 ° C at 5 ° C per minute

Heated up to 250 ° C at 20 ° C per minute

250. C constant temperature 10.5 min

Total analysis time 45 minutes

人口 Population

Temperature 250 ° C

Split ratio 10: 1

Total flow rate 9.8mlZ min

Carrier gas Ultra high purity helium

Sample IV.

2 μ \

FID (hydrogen flame ionization) detector.

Figure 1 shows the chromatograph obtained for lavender steam distilled water, and Figure 2 shows the chromatograph obtained for Lavender mono essential oil. The peak patterns are different between Fig. 1 and Fig. 2, and it was confirmed that the composition of lavender steam distilled water and lavender essential oil differ.

Claims

The scope of the claims

[1] A sedative composition containing steam distilled water of lavender.

[2] The composition for sedation according to claim 1, wherein the lavender's steam-distilled hydropower is obtained from the above-ground part or the whole plant power of lavender.

[3] The sedative composition according to claim 1 or 2, wherein the lavender is Okamurasaki or an improved variety thereof.