JPH07305089A - Conception promoter - Google Patents

Abstract

PURPOSE:To obtain a conception promoter comprising low-boiling essence of a plant of the family Labiatae, activating action of the brain by stimulation of the sense of smell with scent, readily promoting conception, having extremely slight problem of safety. CONSTITUTION:This promoter comprises low-boiling essence of a plant of the family Labiatae. The essence is preferably obtained by immersing a plant material of a plant of the family Labiatae such as perilla, spearmint, sage or peppermint or a processed material of the plant material in a low-boiling solvent such as n-hexane or an ether in an amount of an equivalent to 10 times as much as that of the plant material at room temperature for several days or at a temperature close to the boiling point of the solvent for several hours. The promoter is preferably absorbed through the nasal cavity by a method for spraying with an aerosol. In the spraying, the promoter is diffused in air in a concentration of 0.1 to 5mg/m<2>.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an idea promoter and a fragrance composition containing the same.

[0002]

2. Description of the Related Art Obtaining an excellent idea is a cornerstone of inventions and discoveries, and is a very important element in social activities such as research, production and sales. For this reason, books related to various ideas are lined up in bookshelves of bookstores, etc., and even though seminars related to ideas have to pay expensive class fees, they are thriving. Conversely,
Such a situation also proves that there is no effective means for the idea.

Therefore, even if a person who seeks a new idea gets stuck in thinking, what can be done to it is:
Slightly recovering keenness by sleeping or resting, refreshing mood by walking or sports, concentrating the spirit by yoga or zazen, and relaxing by coffee, cigarettes, alcohol etc. It's just that, and these are also suspicious about the effect.

On the other hand, regarding the effects of herbs or plants on humans, the scents of herbs or plants include, for example, indulge in herb tea of bodhi tree before going to bed in France and wish for a good night's sleep. It was mainly known for its sedative effect, such as taking it for a purpose.
Further, it has not been known at all that plants of the Labiatae family have an action of promoting ideas, as far as the scent of lavender and the action of promoting secretory immunoglobulin secretion are known.

[0005]

The present invention has been made in view of such a situation, and an object thereof is to provide a means for easily promoting an idea.

[0006]

[Means for Solving the Problems] When the present inventors are studying the effect of stimulation via the olfactory sense on brain activity, a phenomenon in which a certain olfactory stimulation activates brain activity I have found From this, we believe that olfactory stimulus by scent stimulates brain activity, and as a result, has an action of promoting idea, and as a result of repeated screening of various scents using the idea promoting action as an index, The inventors have found that the plant contains a substance having such an action, and have completed the invention.

(1) Idea Promoter of the Present Invention The idea promoter of the present invention comprises a low boiling point essence of a Lamiaceae plant. Specific examples of the Lamiaceae plants include Perilla (Perilla frutescens) and Sage (Salvia offinali).
s), Spearmint (Mentha spicata), peppermint
(Mentha piperita), thyme (Thymus vulgalis), mint (Mentha arvensis), marjoram (Origanum majora)
na L.), oregano (Oruganum vulgare L.), rosemary (Rosmarinus officinaris L.), lavender (Lav)
andula officinalis L.) and the like. The low boiling point essences of these plants all contain substances that stimulate the sense of smell and promote ideas.

In the present invention, the low boiling point essence means an extract obtained by extracting a whole or a part of a plant body or a processed product such as a dried product with a solvent, a solvent-removed product of the extract, its purification, and a fractionated product. Among them, it means a general term for those containing a large amount of low boiling point components.

A method for obtaining an extract from a plant is to add a solvent to a plant or a processed product of the plant in the same amount to 10 times as much as that of the plant, and leave the solution at a boiling point of around several days at room temperature. It may be immersed for several hours under heating conditions. You may add stirring suitably. After that, insoluble matter may be removed by filtration, or the solvent may be removed by distillation under reduced pressure. However, in this case, care must be taken not to lose the low boiling point component. Furthermore, the extract or its solvent-removed product may be purified and fractionated by liquid-liquid extraction or column chromatography.
The solvent used for extraction is not particularly limited, but alcohols such as methanol and ethanol, ethers such as diethyl ether and tetrahydrofuran, ketones such as acetone and methyl ethyl ketone, chloroform, halogenated hydrocarbons such as methylene chloride, and acetonitrile. Examples of the organic solvent include nitriles such as the above, esters such as ethyl acetate, hydrocarbons such as normal hexane and petroleum ether, and these may be used alone or in combination of two or more kinds. Among these, preferred are solvents having a low boiling point, such as normal hexane, ether and methylene chloride.

The essence thus obtained can be formed into various flavor compositions according to a conventional method. Specific examples of the fragrance composition include cosmetics such as cologne and perfume, room fragrances and car fragrances, and incense and paste.

(2) Action of the idea promoting agent of the present invention As shown in Examples below, the idea promoting agent of the present invention activates brain activity through olfactory stimulation to promote the idea. Therefore, to maximize the effects of the present invention. The idea promoter of the present invention may be effectively absorbed through the nostrils. Examples of such a method include a method of spraying with an aerosol and a method of vaporizing with heat such as incense and inhaling. By thus stimulating the sense of smell, the idea promoting agent of the present invention can enhance the quality of idea. The dose of the idea promoting agent of the present invention required to obtain such an action is
It is preferable to diffuse it in the air at about 0.01 to 10 mg / m ² for inhalation, and a more preferable dose is 0.1.
Inhalation at a concentration of ~ 5 mg / m ² . or,
The idea promoting agent of the present invention has herbs as the bases, and therefore has very few safety problems.

[0012]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

Example 1 Production Example 1 To 1 kg of whole rosemary grass, 5 liters of normal hexane was added, and the mixture was heated under reflux for 2 hours for extraction, and then the insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to give an idea promoting agent 1. 125 g was obtained.

Example 2 Production Example 2 5 kg of diethyl ether was added to 1 kg of whole sage grass, heated under reflux for 2 hours for extraction, insoluble matters were removed by filtration, and the solvent was distilled off under reduced pressure to give 109 g of idea promoter 2. Obtained.

Example 3 Production Example 3 To 1 Kg of whole lavender grass, 5 l of diethyl ether was added, and the mixture was heated under reflux for 2 hours for extraction, and then the insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to give 235 g of the idea accelerator 3. Obtained.

Example 4 Production Example 4 To 1 Kg of whole grass of spearmint, 5 l of diethyl ether was added, and the mixture was heated under reflux for 2 hours for extraction, and then the insoluble matter was removed by filtration, the solvent was distilled off under reduced pressure, and 113 g of the idea promoting agent 4 was added. Obtained.

Example 5 Production Example 5 To 1 Kg of whole peppermint plant was added 5 liters of normal hexane, and the mixture was heated under reflux for 2 hours for extraction, and then the insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to give 161 g of idea promoter 5. Obtained.

Example 6 Production Example 6 To 1 kg of whole oregano grass, 5 l of methylene chloride was added, and the mixture was heated under reflux for 2 hours for extraction, the insoluble matter was removed by filtration, the solvent was distilled off under reduced pressure, and 186 g of the idea promoter 6 Obtained.

Example 7 Production Example 7 To 1 Kg of whole plant of marjoram was added 5 l of tetrahydrofuran and refluxed under heating for 2 hours for extraction, then insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to obtain 204 g of idea promoter 7. It was

Example 8 Production Example 8 To 1 kg of whole grass of Perilla frutescens, 5 l of petroleum ether was added and heated under reflux for 2 hours for extraction, and then insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to give 151 g of idea promoter 8. Obtained.

Example 9 Production Example 9 To 1 Kg of thyme whole grass, 5 l of acetone was added, and the mixture was heated under reflux for 2 hours for extraction, and then the insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to obtain 119 g of idea promoting agent 1. It was

Example 10 Production Example 10 To 1 Kg of whole grass of basil was added 5 l of diethyl ether and refluxed under heating for 2 hours for extraction. Then, insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to give 107 g of idea promoter 1. Obtained.

Example 11 Production Example 11 To 1 kg of whole plant of peppermint, 5 liters of cyclohexane was added and heated under reflux for 2 hours for extraction, and then insoluble matter was removed by filtration and the solvent was distilled off under reduced pressure to obtain 162 g of idea promoting agent 1. It was

Example 12 Idea promotion test 23 randomly selected male and 22 female panelists (ages 18 to 50), each having about 10 persons, to avoid bias, 4
I divided them into groups and instructed them to freely give as many questions as possible about how to use empty cans of Cucumber. 12 minutes after the start, the idea promoter 1 of Example 1 was added to the first group, the idea promoter 5 of Example 5 was added to the first group, and 0.3 mg of orange essence (commercially available product) was used as a control for the first group.
It was diffused into the air at a concentration of / m ² and administered via exhaled breath for 8 minutes. The remaining one group did nothing and was used as a blank group. The answers obtained during the 20 minutes were classified into 4 based on the TCT creativity test guidebook.

(1) Task-dependent reaction (Td): When the information set as a task is accepted as it is and an attempt is made to solve the task within a common sense framework. (Example: vase, ashtray, insect holder) (2) Task transformation reaction (Tm): When trying to solve a task by breaking the common sense framework and changing the viewpoint while accepting information on the set task. (Illustration: Kankeri,
(Flowerbed enclosures, chairs, rattles) (3) Isomorphic regeneration reaction (Ho): Focusing on specific information among various kinds of information indicated by the task, discarding unnecessary information,
When trying to solve an issue within the framework set by the issue. (Practical example: Tyco, weight, frisbee, accessory) (4) Aberrant regeneration reaction (He): When trying to solve the problem without being bound by the framework set by the problem. (Illustration: knife, screw, shoe sole, electric resistor)

Here, it is said that Tm and Td represent quantitative aspects of the reaction, and Ho and He represent qualitative aspects of the reaction. Therefore, it is understood that the sum of Ho and He may be used as an index for promoting the idea. Therefore, the increase / decrease rate of Ho and He before and after the administration of the idea promoting agent was determined by the following formula.

Rate of increase / decrease (%) = (Hoa + Hea- (Ho
p + Hep)) / S * 100 Hoa: Ho after administration, Hea: He, Ho after administration
p: Ho before administration, Hep: He before administration, S: Total number of responses

The average value of the increase / decrease rate of each group is shown in FIG. From this, it is clear that the idea promoting agent of the present invention has an excellent idea promoting action. Further, the idea promoting action does not have to be any as long as it stimulates the sense of smell like a fragrance, and it is also understood that only a specific scent has this action.

Example 13 Effect on Electroencephalogram The electroencephalogram of the subject of Example 12 was monitored using an electroencephalogram topograph measuring device (DP1100). As brain waves, we monitored beta waves, which are said to be indicators of creative brain activity such as ideas. As the idea promoting agent, the idea promoting agent 1 was used, and it was monitored before, immediately after the administration of the idea promoting agent, 30 seconds after the administration, and 1 minute after the administration. The results are shown in Figure 2. From this, it is understood that the beta wave actively appears in the right hemisphere of the brain by the administration of the idea promoting agent and promotes the idea.

Example 14 Effect on EEG The idea promoting agents of Examples 2 to 11 were diffused in air at 0.3 mg / m ² and administered to a subject via exhaled breath, before and 1 minute after the administration. Beta waves were measured. The results shown in FIG. 3 all show that beta waves actively appear in the right hemisphere of the brain, promoting the idea.

Example 15 Effects on EEG The effects on the EEG of the idea stimulant 1 of Example 1 and the scent components of rosemary, which had a low boiling point, were examined in the same manner as in Example 14. . Fractions low in low-boiling components were obtained by steam distillation of whole rosemary grass. The results are shown in Fig. 4. From this, idea promoter 1
It can be seen that the fraction with less low boiling point component has less effect on the electroencephalogram in comparison with.

Example 16 Formulation Example The following components were solubilized by stirring at room temperature and filled in a glass bottle equipped with a cotton core to prepare a room fragrance. Hereinafter, the numerical values represent parts by weight. Ethanol 50 Isopropanol 40 Idea promoter 1 10

Example 17 Formulation Example The components below were stirred and solubilized at room temperature and filled in a glass bottle equipped with a cotton core to prepare a room fragrance. Hereinafter, the numerical values represent parts by weight. Ethanol 50 Isopropanol 45 Idea promoter 25

Example 18 Formulation Example The following components were stirred and solubilized at room temperature and filled in a glass bottle equipped with a cotton core to prepare a room fragrance. Hereinafter, the numerical values represent parts by weight. Ethanol 59 Isopropanol 40 Idea promoter 3 1

Example 19 Formulation Example The following components were stirred and solubilized at room temperature and filled in a glass bottle equipped with a cotton core to prepare a room fragrance. Hereinafter, the numerical values represent parts by weight. Ethanol 50 Isopropanol 40 Idea promoter 4 5 Idea promoter 5 5

Example 20 Formulation Example The following components were solubilized with stirring at room temperature and filled in a glass bottle equipped with a cotton core to prepare a room fragrance. Hereinafter, the numerical values represent parts by weight. Ethanol 50 Isopropanol 40 Idea promoter 6 10

Example 21 Formulation Example The following components were stirred and solubilized at room temperature and filled in a glass bottle equipped with a cotton core to prepare a room fragrance. Hereinafter, the numerical values represent parts by weight. Ethanol 50 Isopropanol 40 Idea promoter 7 10

Example 22 Formulation Example The following components were stirred and solubilized at room temperature to obtain cologne. Ethanol 50 Water 40 Idea promoter 8 10

Example 23 Formulation Example The following components were stirred and solubilized at room temperature to obtain cologne. Ethanol 50 Water 45 Idea promoter 9 5

Example 24 Formulation Example The components below were stirred and solubilized at room temperature to obtain cologne. Ethanol 50 Water 40 Idea promoter 10 10

Example 25 Formulation Example The following components were stirred and solubilized at room temperature to obtain cologne. Ethanol 50 Water 49 Idea promoter 11 1

[0042]

INDUSTRIAL APPLICABILITY The idea accelerating agent of the present invention can easily promote creativity, and is very useful for creative activities.

[Brief description of drawings]

FIG. 1 is a diagram of a change rate of an idea.

FIG. 2 is a topograph of brain waves (beta waves).

FIG. 3 is a topograph of an electroencephalogram (beta wave).

FIG. 4 is a topograph of an electroencephalogram (beta wave).

Claims (3)

[Claims] 1. An idea promoting agent comprising a low boiling point essence of a Lamiaceae plant. 2. The idea promoter according to claim 1, wherein the Lamiaceae plant is one or more selected from lavender, rosemary, spearmint, peppermint, peppermint, marjoram, thyme, basil, oregano, sage, and perilla. . 3. A fragrance composition containing the idea promoting agent according to claim 1.