JPH01254628A - Agent for depressing consciousness level - Google Patents

Abstract

PURPOSE:To obtain the subject composition useful for relieving from a physiological and psychological state caused by excessive excitation of consciousness level, e.g., irritation, anxiety or tension and normalizing the psychologic action, by using a specific valerian oil fraction obtained by vacuum distillation as an active component. CONSTITUTION:The objective agent contains, as an active component, a valerian oil fraction prepared by removing the fraction distilled out at <=80 deg.C under 0.08mmHg pressure by vacuum distillation. The fraction is free from malodor, has weak woody spicy aroma and is applicable without giving influence to the balance of the odor of the whole compound perfume. Preferably, the composition is added to a flavoring product in an amount of 0.1-5% and the active amount of the fraction is inhaled continuously or for a prescribed period by the aid of the fragrance emitted from said product.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention provides a method for sedating the conscious level of humans or animals by vacuum distillation under an atmospheric pressure of 0.08 mmHg, except for the part distilled out at temperatures below 80°C. The present invention relates to a composition for sedating the conscious level of a human or animal by inhaling a valerian oil fraction.

[Prior Art] Traditionally, so-called aromatherapy (
A treatment method called aroma therapy is known. The fragrances that have been used in aromatherapy are mainly natural essential oils that have been handed down from ancient America, and in terms of the ``effect of calming the level of consciousness'' that is the issue of the present invention, lavender, bergamot, marjoram, Essential oils such as rose, mace, ginger, thyme, nutmeg, clary sage, and cinnamon are said to be highly effective (Osamu Okuda 7'O
"? Terrahy Ffl Nozomi Jaka'14; No, 140 (
1983) pp, 19-26) In addition, the research group of P. Rovesti et al.
Rose, camphor, neroli, bergamot, sage,
Using aerosols, you can use single essential oils such as civet, myrte, valerian wormwood, chamomile, geranium, yarrow hollyhock, orange blossom, mint, etc., or mixtures based on acacia, phage, gardenia, neroli, ovobonax, rose, lilac, etc. When administered by inhalation to neurotic thinking patients suffering from psychological anxiety or psychological tension, it was reported that the effect was similar to that of a sedative. (S, P, CAug47 However, these effects are subjective and qualitative, and their effectiveness is not necessarily satisfactory.In addition, many of the essential oils mentioned above have strong scents, Since i7J 12F is imparted to the overall fragrance when creating a blended fragrance by perfume mixing, the balance between the intensity and palatability of the fragrance and the effective amount for producing effects cannot always be satisfied. Among the effective essential oils of I'Lovesti mentioned above, valerian essential oil has been known as a sedative for hysteria since ancient times, and some pharmaceutical encyclopedias also mention its sedative effect due to its scent, and it has the most famous sedative effect. Although it has been considered as an essential oil, the main components are valeric acid and its derivatives, which have a bad odor, and when used as a fragrance ingredient, it has poor palatability.

[Problems to be Solved by the Invention] In view of the above circumstances, the present inventor conducted intensive research to obtain valerian essential oil, which has no bad odor and has an excellent effect of truly calming the level of consciousness. Through distillation below, the valerian fraction, excluding the part that flows out below 80℃, has a depressing, spicy aroma, and although it has no malodorous components, it has a strong sedative effect on the level of consciousness when inhaled. We have discovered the completely new fact that the present invention has the following properties, and based on this knowledge, we have completed the present invention.

[Means for Solving the Problems] That is, the present invention uses vacuum distillation to reduce the atmospheric pressure to 0°08 m.
It is characterized by containing as an active ingredient a valerian oil fraction (hereinafter abbreviated as "valerian active fraction") obtained by distillation fractionation under mHg and excluding the part distilled out at temperatures below 80°C. A composition that sedates the level of consciousness of a human or animal.

The effect of calming the level of consciousness referred to here refers to the effect of relieving humans or animals from the physiological and psychological states caused by excessively elevated levels of consciousness such as irritation, anxiety, and tension that they experience in their daily lives, and calming their mood. It refers to the effect of normalizing mental activity.

In addition, the term "composition" refers to a composition in which an effective amount of "active fraction of valerian" is inhaled to stimulate olfactory receptors or to be absorbed into the body through the respiratory tract, producing an effect. In addition to fragrance products such as air fresheners,
It also includes cosmetic stones such as soap and toothpaste, and pharmaceuticals.

The present invention will be explained in detail below.

The "valerian active fraction" in the present invention is a known substance, and valerian oil is heated at an atmospheric pressure of 0.08 mm l-1.
This is a valerian oil fraction that is distilled under 80° C. and is a mixture of high-boiling components of valerian essential oil.

For the valerian oil fraction, the standard commercial variety, Va.
The fractionated part of lerlan root oil (Yamamoto Co., Ltd.) is used in the present invention, but any fractionated part of any component composition of valerian oil from Japan, China, Europe, etc. can also be used.

Furthermore, a fraction of essential oil obtained from natural valerian by methods such as distillation and extraction can be used in the present invention.

Therefore, Valeriana.

ff1clnalls L and its subspecies) obtained by various means such as steam distillation and extraction.
An effective fraction can also be obtained by distilling the mixture under reduced pressure.

``The valerian active fraction can be obtained by other methods than vacuum distillation, such as atmospheric distillation, column chromatography, and GC fractionation, but from an industrial standpoint, vacuum distillation is considered preferable.

These "valerian active fractions" can be used alone or in mixed compositions with various media that can be mixed with the "valerian active fraction" (eg, ethanol, perfumes, perfumed products).

When a blended fragrance is used as a medium, the scent of each individual component contributes to the overall scent of the blended fragrance, but as mentioned above, the "active fraction of valerian" does not have a bad odor and has a weak, depressing, spicy aroma. It does not have a negative effect on the aroma balance of the entire blended fragrance.

From this point of view, there is a high degree of freedom in the amount of ``valerian active fraction'' used.
Even if it is added to a blended fragrance in an amount of % or more, it is possible to produce a conscious sedative effect without impairing the balance of the overall fragrance tone.

Furthermore, from the viewpoint of significantly producing a conscious sedative effect, it is possible to incorporate ``valerian active fraction'' in a range of 5% to 50% by weight in a blended fragrance.

Further, a balm composition containing the "valerian active fraction" alone or the above-mentioned "palerian active fraction" as a medium can be mixed with ethyl alcohol and used as an eau de cologne.

It is also possible to use the active fraction of valerian alone or the fragrance compositions containing the active fraction of valerian described above to perfume a perfumed product as a carrier. Perfumed products include fragrances, room air fresheners, creams, emulsion cosmetic powders, body lotions, deodorant sticks, toothpastes, hair products, and aerosol products.

Furthermore, it can also be used as an inhalation drug containing the active fraction of valerian as an active ingredient.

[Pharmacological effects] 1. Effect of prolonging the anesthetic action time on mice (1) Experimental method ICR male mice (6-7 weeks old, weight 80-35 g)
, an air flow containing the test substance (21 air per minute containing 1-2 mg of test substance) f! The difference in bendoparbital sleep time (55 mg/kg intraperitoneal injection) was compared between a group in which the substance was inhaled for 0:4 hours and a group in which the substance was not inhaled.

(2) Test substance Substance A: Valerlan root oil (manufactured by Yamamoto Co., Ltd.) Substance B: “Valerian active fraction °.

The experimental results are shown in Table 1.

Table 1 shows that the average sleeping time of the inhalation group was prolonged; negative values indicate that it was shortened.

[Administration Method and Dose] The present invention is characterized by administration by inhalation, and unlike stimulants administered orally, subcutaneously, or intramuscularly, it is more effective than stimulants when given to healthy individuals. Since valerian is expected to have a mild sedative effect, the above-mentioned ``valerian active fraction'' may be used as part of a composition containing alcohol or fragrance, or as part of a fragrance used in perfumed products. Preferably, it is given as part of a composition.

The effectiveness of the sedative inhaler of the present invention varies by age,
Shadow 2' in gender, mental and physical condition, etc.! Therefore, in some cases, doses outside the range shown below may be administered, but in general, when administering to healthy individuals, the dose of "parelliasis active fraction" is 0.
It is preferable to administer an effective amount of "valerian active fraction" by inhalation over a certain period of time or continuously by means of the aroma volatilized from a flavored product containing 1% to 5%.

[Examples] Next, examples and comparative examples will be given to specifically clarify the present invention. The present invention is not limited thereby. The blending amount is in weight%.

Example 1 "Active substances" of standard commercial varieties of perfumes and colognes, each at a weight concentration of 5
%, 10%, 15%, and 20% of a fragrance preparation with a citrus scent is dissolved in 95% aqueous alcohol to a weight concentration of 3% to prepare an eau de cologne. Further, the same blended fragrance is dissolved in 95% aqueous alcohol to a weight concentration of 20% to prepare a perfume.

These colognes have the effect of calming the human consciousness level by inhaling their scent.

Example 2 Indoor air spray The aerosol was filled according to the following formulation.

“Valerian active fraction” f! : Contains 15% fragrance (
Hereinafter, it will be abbreviated as effect perfume 1'4A. ) 5-functional alcohol 95% 56 Suban 85
2 twin 81
1 These aerosols can be used by inhaling the aroma.
It has the effect of calming the level of human consciousness.

Example 8 Soap (1) Soap base 95.0 (
2) Effect research fee A5.0 (3) Pigment 3f! Soaps were manufactured by adding the J amount manufacturing methods (2) and (3) to the soap base and then kneading it in two machines or forming a border.

These soaps have the effect of calming the human consciousness level by inhaling the aroma when used.

Example 4 Shampoo (1) Alkyl sulfate triethanolamine salt 15.0
(2) Coconut fatty acid monoethanolamide 5.0 (
3) Ethylene glycol monostearate 2.0 (4)
Preservative: Appropriate amount (5) Pigment: Appropriate amount (6) Effect Perfume 4t4A 3.0 (7) Purified water Residual manufacturing methods (1) to (6) were dissolved in (7) with stirring to obtain a shampoo.

These shampoos have the effect of calming the human consciousness level by inhaling the fragrance when used.

Example 5 Hair rinse (1) Alkyltrimethylammonium chloride 3.0 (2) Cetyl alcohol 1.0 (3) Preservative
0.1(4) Glycerin
5.0 (5) Effect fragrance A
0.4(6) Pigment
Appropriate amount (7) POE (8 mol) Stearyl ether 0.6 (8) Purified water
The remaining production methods (1) to (8) were mixed and dissolved at 80°C, and the mixture was allowed to cool to room temperature to obtain a hair rinse.

These hair rinses have the effect of calming the human consciousness level by inhaling the scent when used.

Example 6 Bath powder (1) Talc 80.0
(2) Effective fragrance composition 20.0 (
Effect Perfume 1"4 A, liquid paraffin, 1:20) Manufacturing methods (1) and (2) were mixed and stirred to obtain a bath powder.

These bath powders have the effect of calming the human conscious water 1 by inhaling the aroma when used.

Example 7 String perfume (1) Effective fragrance composition 90.0 (
Effect research fee A, Vaseline, 5:4) (2) Glyceryl trimyristate 8.0 (3)
) Perfume 2.0 Production Methods (1) to (3) were mixed and stirred to obtain a line perfume.

C. These line perfumes have the effect of calming the human consciousness level by inhaling the scent when used.

[Effects of the Invention] The present invention relieves humans and animals from physiological and psychological states caused by excessively elevated levels of consciousness such as irritation, anxiety, and tension that they experience in their daily lives, calms their mood, and reduces mental activity. It has the effect of calming the level of consciousness by bringing it back to normal.

Patent applicant: Shiseido Co., Ltd.

Claims (1)

[Claims] A composition that calms the level of consciousness of humans or animals, characterized in that it contains as an active ingredient a valerian oil fraction obtained by removing the part that distills out below 80°C under an atmospheric pressure of 0.08 mmHg by vacuum distillation.