JP2005047935A - Slimming composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a sympathetic activator with less side effects as an autonomic modulator which has deep relationship with in vivo homeostatic maintenance in this stressful contemporary society. <P>SOLUTION: The subject slimming composition contains one or more kinds selected from a fennel oil, a grapefruit oil, a pepper oil, a hyssop oil, a sage oil, an estragon oil, a eucalyptus oil, a rosemary oil, a cinnamon oil, a clove oil, an ilang-ilang oil, a ginger oil, a geranium oil and olibanum, and caffeine. A slimming method is to apply the composition to the skin, to make a flavor component smelt, and to make caffeine percutaneously absorbed. These are preferable slimming composition and slimming method. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a slimming composition and a slimming method including a fragrance that activates sympathetic nerves. More specifically, the present invention relates to a slimming composition and a slimming method containing at least one essential oil.

  The autonomic nervous system is classified into a sympathetic nervous system and a parasympathetic nervous system based on the difference in function, and regulates the functions of each organ and organs. Among them, activation of the sympathetic nervous system is known to have various effects such as an increase in heart rate, suppression of gastrointestinal activity, etc., and it is also caused by mental tension while receiving effects of hormones and the like. On the other hand, it is well known traditionally that fragrances have various mental effects, and scents that calm the feelings and scents that enhance the mood have long been known.

  Furthermore, in recent years, the sedative and arousal effects are being demonstrated by electroencephalogram measurement and the like. The effects of fragrances on the whole body system, including mental effects, have been clinically demonstrated throughout the world as “aromatherapy”. However, as an action of fragrances on the autonomic nervous system, the parasympathetic nervous system is active. Only a part of the fragrances to be converted has been reported, and no fragrances acting on the sympathetic nervous system have been found so far (Japanese Patent Laid-Open No. 11-209294).

  In a stressful modern society, it has been desired to provide a sympathetic nervous system activator with few side effects as an autonomic nervous system regulator deeply involved in maintaining homeostasis.

As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention have found that a fragrance of a certain fragrance has a sympathetic nerve activation action, and have completed the present invention.
That is, the present invention relates to a sympathetic nerve activating fragrance comprising at least one fragrance as an active ingredient, a skin external preparation characterized by containing them as an active ingredient, and miscellaneous goods.

  The perfume here is fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil or olive nam. It is preferable that these fragrances can be used in combination. Moreover, it is preferable to contain limonene, pinene, myrcene or benzyl benzoate, and furthermore, these fragrances can be used in combination.

Therefore, the present invention is selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olive nam. A sympathetic nerve-activating fragrance composition characterized by containing one or more selected from the above, or containing one or more selected from limonene, pinene, myrcene and benzylbenzoate I will provide a.
The present invention further provides a skin external preparation composition or sundries characterized by containing the above-described perfume composition as an active ingredient.

  The present invention is further selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olive nam A fragrance composition for slimming comprising one or more selected from the group consisting of one or more selected from limonene, pinene, myrcene and benzylbenzoate To do.

  The present invention is further selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olive nam A fragrance composition with improved memory ability, characterized by containing one or more selected from the above, or one or more selected from limonene, pinene, myrcene and benzylbenzoate To do.

The present invention is further selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olive nam There is provided a slimming method characterized in that one or two or more selected from the above can be dissipated, or one or more selected from limonene, pinene, myrcene and benzylbenzoate.
The present invention further provides a slimming composition comprising the sympathetic nerve-activating fragrance composition as an active ingredient. This composition preferably further contains caffeine.

The present invention is described in detail below.
Essential oil production
Pepper oil Pepper oil is obtained by steam-distilling immature berries of a Piper genus plant belonging to the family Pepperaceae with the skin turned black. Its aroma has an exciting refreshing sensation and is widely used around the world as a food spice (from Japan Fragrance Association, "Encyclopedia of Scents").

The clove oil clove is an evergreen tree of the myrtaceae family and is called “chome” in Chinese medicine. Clove bud oil is obtained by picking the flower buds before flowering, drying them well and steam-distilling them, and clove leaf oil is obtained by steam-distilling from leaves or twigs. Both are used as cosmetics and food fragrances. . It has a woody and spicy fragrance that contains Eugenol as the main ingredient (from Japan Fragrance Association, “Scented Encyclopedia”).

Estragon oil Estragon is an Artemisia drueunculus belonging to the genus Artemisia and is also used in French escargot cooking. All the above-ground grass in the flowering period cultivated in Europe, North America, etc. is cut and dried and subjected to steam distillation to obtain oil. The main component of the fragrance is Estragole, which has a sweet anise-like fragrance (from “Scented Encyclopedia”, edited by the Japan Fragrance Association).

Hyssop oil hyssop is a plant belonging to the family Lamiaceae, which has been used as a medicine since ancient times. The leaves and flower spikes are cut off and steamed to obtain a refreshing oil (from Japan Fragrance Association, “Scented Encyclopedia”).

Sage oil sage is a herb classified as Lamiaceae, Akigiri, and is distributed in various parts of the world. The oil is obtained by steam distillation of dried leaves and has a fresh herbal fragrance. It is also widely used as a spice for foods in various parts of the world (from the Japanese Fragrance Association, “Encyclopedia of Scents”).

Eucalyptus oil Eucalyptus is an evergreen tree that belongs to the Myrtaceae family and is also important as wood. Various oils are distributed in the tropics and subtropics, and dried leaves and twigs are subjected to steam distillation to obtain oil (from Japan Fragrance Association, “Scented Encyclopedia”).

Grapefruit oil Grapefruit is called Citrus paradis Macf. And is an evergreen tree of the citrus family native to the West Indies. It is a fruit with a refreshing sweetness and bitterness. The main aroma is limonene and has a unique citrus scent (from Japan Fragrance Association, “Encyclopedia of Scents”).

Fennel oil Fennel belongs to the Apiaceae family. It is a perennial plant that originates in Europe and is used as a medicinal herb since prehistoric times. It came to Japan during the Heian period and is now widely cultivated all over the world. The fruit has aroma and sweetness, and essential oil is obtained by steam distillation. The main component of the essential oil has a sweet aroma that is characteristic of anethole (from Japan Fragrance Association, “Scented Encyclopedia”).

Rosemary oil Rosemary oil is a refreshing sweet-scented aroma component obtained by steam-distilling leaves and flowers of the Lamiaceae evergreen shrub (Rosmarinus officinalis) widely distributed in countries along the Mediterranean coast. It is widely used as an active ingredient of pharmaceuticals and as a flavoring agent and a fragrance for cosmetics (from "Scented Encyclopedia").

Ylang Ylang Ylang Ylang Ylang Ylang can be obtained by steam distillation of a plant (Canning odorata) belonging to the family Anonaceae as it is or by solvent extraction of fresh flowers with petroleum ether or the like. One of the most important fragrance plants known since ancient times, it has a floral aroma reminiscent of mild jasmine. It is used as a harmonizing agent for flower fragrance-like blended fragrances and also for food fragrances (from “Scented Encyclopedia”).

Cinnamon oil Cinnamon is a camphoraceae evergreen tree that originates in Southeast Asia, and its aroma is characterized by a sweet aroma and a slightly astringent stimulating taste. Cinnamon oil is obtained by crushing the skin and steam distillation, but oil can also be obtained by steam distillation of leaves and twigs. Utilizing the characteristics of each form, it is widely used in foods, cosmetics, pharmaceuticals, etc. (from “Scented Encyclopedia”).

Ginger oil Ginger oil is obtained by drying and steam-distilling rhizomes of ginger family perennial herbaceous ginger (Zingiber officinale Roscoe) that is also used for cooking as it is. The flavor differs slightly depending on the production area, and it is used for beverages, meat storage products, seasonings, etc. according to its characteristics (from "Scented Encyclopedia").

Geranium oil Geranium is a plant belonging to the genus Pelargonium belonging to the family Olympaceae. Geranium oil is obtained by collecting its branches and leaves before flowering, leaving them for about a day and steam-distilling them, and is used as a fragrance material. It is so important that it gets into the finger of a book. Because of its strong rose-like odor, it can be used in all formulated fragrances, and is stable and stable in alkaline media, so it is often used for flavoring high-grade soaps and detergents (from "Scent Encyclopedia").

Olibanum northeast America, South Arabia, also native to the poor soils of India, Furousou eyes Burseraceae Geraniales Burseraceae of the plant Boswellia carterii Birdw shrubs or small arbor resin exuded from the bark of such. Also known as frankincense or frankincense. The resin itself has a weak fragrance, but when it is burned, it gives off a very strong and unique odor and has long been used in religious ceremonies. Resinoids obtained by organic solvent extraction from this resin are used for oriental blended fragrances (from "Encentric Encyclopedia").

Description of other ingredients
Limonene typical monocyclic terpene. Colorless liquid. It is an optical isomer of dextrorotatory d (+)-and levorotatory l (-)-. The α form is obtained by fractionating the essential oil obtained by steam distillation of the peels of oranges, lemons, etc., and the l form is obtained from mint oil (from synthetic perfume chemistry and product knowledge by Motoichi Into Chemical Industries Daily).
A typical pinene terpene hydrocarbon, it is contained in many essential oils, and is most abundant in pinaceae plants.

Produced in large quantities by pyrolysis of myrcene β-pinene. Naturally, it is present in bay oil, verbena oil, hop oil, galvanum oil, lemongrass oil and the like. It is a colorless to light brown liquid with a sweet balsam or resinous fragrance.
Benzyl benzoate benzyl benzoate . It exists in trubalsum, peruvian balsam, jasmine oil, cinnamon oil and cananga oil. A slightly floral and sweet balsam-like odorless liquid. Widely used as a retention agent, modulator, and as a solvent for balsam, resinoids, etc. for heavy floral oriental blends.

The blending amount of these essential oils in the present invention is appropriately selected depending on the kind of the essential oil to be selected and the relationship with other blending components, and is not particularly limited. Usually, 0.001 to 100% by weight, preferably 10 to 100% by weight, is used in the fragrance composition (in the fragrance formulation).
The composition of the present invention is, for example, a fragrance composition for external preparations for skin such as cosmetics, pharmaceuticals, and quasi-drugs, a fragrance composition for miscellaneous goods such as incense and a space spray, and a fragrance composition for beverages and foods. However, it is not limited to these uses.
Moreover, according to the specific aspect which this composition can take other than the said sympathetic nerve activation fragrance | flavor, a general fragrance | flavor component can be mix | blended unless the effect of this invention is impaired.
Furthermore, sympathetic nerve activation is known to cause slimming and improved memory, and the above essential oil composition can also be used for such applications.

  The perfume composition of the present invention can be used by itself, and further, other sympathetic nerve activators such as capsaicin, zingerone, piperine, and / or other anti-obesity and slimming ingredients such as caffeine Xanthine derivatives, Chinese tea, green tea extract, herbal medicines such as fennel, peonies, shrimp, lavender, pepper, etc., tamarind, gymnema sylvester, inosit, dextran sulfate, etc.

  In particular, when the present invention is used for slimming, the slimming effect can be further enhanced by using it together with caffeine. That is, due to the synergistic effect of noradrenaline and caffeine secreted into the body by the activation of sympathetic nerves, fat burning occurs and a higher slimming effect is obtained. This synergistic effect is apparent from, for example, Example 2 and Example 3. In Example 2, it is clear that blood catecholamines (adrenaline and noradrenaline) are increased by the fragrance composition of the present invention. In Example 3, it is clear that the increase in the expression of uncoupling protein-3 by noradrenaline and caffeine occurs synergistically.

As described in Japanese Patent Application No. 2001-258346, weight loss occurs due to energy consumption (fat consumption) by uncoupling protein-3. Therefore, it is reasonably estimated that the slimming effect is generated synergistically by adding caffeine to the fragrance composition of the present invention.
In addition, the composition of the fragrance composition of the present invention and caffeine may be a mixture thereof. When such a mixture is applied to the skin, the aroma component evaporates and is sniffed from the nose, and caffeine is absorbed transdermally.

The amount of caffeine is 0.001 to 5% by weight as a drug. The standard of the fragrance flavoring rate is as follows.
Product type Perfume fragrance rate Lotion 0.001-0.05
Latex 0.03-0.2
Cream 0.05-0.2
Gel 0.005-0.2
Aerosol 0.001-30
Bath salt 0.2-3
Fragrance / Room Fragrance 1-100
Incense 1-30
Foam pack 0.03 ~ 0.2

Evaluation of autonomic nerve activity Autonomic nerves are broadly divided into sympathetic nerves and parasympathetic nerves, which regulate internal organs and glands. At that time, adrenaline and acetylcholine released from nerve endings directly act on the gland and muscle, and the action of the heart, blood vessels, pupils, gastrointestinal activity, sweat gland and the like is almost antagonistically regulated. Accordingly, various methods for measuring autonomic nerve activity have been reported, including a method for directly measuring the amount of adrenaline and acetylcholine, and a method for measuring heart rate, blood flow / blood pressure, sweating, pupil reaction, etc. "Fukumura Publishing").
In measuring the action of the fragrance on the autonomic nervous system, the measuring method is not particularly limited as long as it is an appropriate method.

EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to these.
Example 1. Measurement of sympathetic activity Heartbeat intervals (beat intervals) or blood pressure fluctuations (blood pressure fluctuations) vary in a complex manner at rest, and are governed by a plurality of systems represented by sympathetic nerves and parasympathetic nerves. Therefore, it is known that the activity of each system can be calculated by frequency analysis of the pulsation interval or blood pressure fluctuation. The high frequency component of heart rate variability shows parasympathetic nerve activity, the low frequency component shows mixed activity of the sympathetic nervous system and the parasympathetic nervous system, while the low frequency component of blood pressure fluctuation shows sympathetic nerve activity (Dainippon Pharmaceutical Data) .

  Thus, sympathetic nerve activity was measured by analyzing systolic blood pressure fluctuations using an autonomic nervous system activity analysis system (Fraclet, manufactured by Dainippon Pharmaceutical Co., Ltd.). The subject measured the upper arm blood pressure value after resting for 5 minutes in a thermostatic chamber at room temperature of 24 ° C., corrected the blood pressure value of the wrist part, and then continuously measured the blood pressure from the wrist part. At the start of measurement, cotton was attached under the nose and blood pressure was measured for 3 minutes without any scent, then the scent was soaked into the nose cotton and blood pressure was measured for 3 minutes. Obtain the low frequency component of the systolic blood pressure fluctuation in the measured value, calculate the sympathetic nerve activity, and obtain the relative value of the sympathetic nerve activity when there is no fragrance (the first half 3 minutes) and the sympathetic nerve activity (the second half 3 minutes). The effect on was measured.

  When presenting fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil, or olivenum, no scent The activation of the sympathetic nerve was recognized 1.2 to 3.0 times as compared with (Fig. 1). When TEC (triethyl citrate) in which no scent was felt was presented, the relative value of sympathetic nerve activity did not change. Further, as a result of GC / MS analysis of the fragrances with activated sympathetic nerves, limonene, pinene, myrcene and benzyl benzoate were found as components common to these effect fragrances. As for these fragrance components, as a result of measuring the sympathetic nerve activity when smelling the scent by the same method, the effect of increasing the sympathetic nerve activity was found (FIG. 2).

Comparative Example 1
In contrast to the essential oils having these activation effects, rose oil, mill oil, marjoram oil, juniper berry oil, patchouli oil and the like had an effect of calming sympathetic nerve activity (FIG. 1).
The attractive and pleasant scent of rose oil roses is well known and recognized all over the world today. Since ancient times, it has been regarded as a queen of flowers. Rose oil is characterized by its strength, scent-lifting and gorgeousness compared to absolute, and is often used for floral bases, shipleys, oriental bases (from "Scented Encyclopedia").

Mill oil A resin that exudes mainly from the bark of the genus Geraniales Burseraceae Commiphora. There are more than 60 species of genus Miralia in Africa and Arabia, and the sap that exudes from the wounds of the bark touches the air to form a deep, sweet and spicy balsam-like block resin. As a blended fragrance, it is often used in oriental tones, and as a flavor, it is used as a mouth preparation and toothpaste that makes use of its bitterness and hotness (from "Scented Encyclopedia").

Marjoram oil Marjoram is a plant of the family Lamiaceae native to the eastern Mediterranean coast. Typical examples include sweet marjoram (Origanum majorana) and Spanish wild marjoram. Marjoram is widely cultivated in temperate areas and is mainly used as a spice. In addition, it is used as a perfume, fragrance, colon, oriental base (from "Encentric Encyclopedia").

Juniper Berry Oil Juniper is a kind of cypress family, Juniperius communis L., which is an evergreen tree with a height of 3m. Widely wild in Europe, Asia and North America. Oil is obtained from juniper's ripe blue-black 2 years fruit. The oil has a balsamic, woody, and pine needle-like fragrance, and is used in fragrances of Western liquors, drinks, and mouth refreshers (from “Scented Encyclopedia”).

Patchouli oil Patchouli is a perennial herbaceous plant from Southern Asia that has little odor when fresh leaves, but smells when dried. Oil is obtained mainly by direct-fired distillation, and its heavy, oriental scent is widely used for floral and citrus scents.

Comparative Example 2
The effects of essential oil and hot water extract on sympathetic nerve activity were compared. The essential oil is pepper oil. As the hot water extract, black pepper and green pepper hot water extract prepared according to a conventional method were used. As a result, compared with the high effect on the scent of essential oil, the scent of hot water extract has no effect, and the scent component contained in the essential oil contributes greatly to the activation of sympathetic nerves. (Figure 3).

Example 2 Increased blood catecholamines due to sympathetic nerve activated fragrance scents Pepper oil and grapefruit oil are taken as examples of sympathetic nerve activated fragrances, and the concentration of blood catecholamines by smelling these fragrances We examined changes. Twelve subjects were each smelled of pepper oil or grapefruit oil, and the concentrations of catecholamines in the blood were compared before sniffing and after smelling for 7 minutes. The subject was seated on a chair and kept at rest for 30 minutes, and then 5 ml of blood was collected and used as a sample before presentation of fragrance.

  Under the nose of the subject who was kept in a resting state, a cotton wool soaked with essential oil was attached to smell the scent, and after 7 minutes, 5 ml of blood was collected again to give a scent. A blood collection tube containing ADTA.2NA was used for blood collection. The collected blood sample was immediately centrifuged at 4 ° C. and 2000 rpm for 10 minutes to collect plasma, and stored frozen until measurement. The measurement of catecholamines in plasma was carried out using a catecholamine analyzer (Tosoh, HLC-) using a post-column fluorescence reaction HPLC method using diphenylethylenediamine, a fluorescent reagent that specifically reacts with catechol nuclei. 8030).

  The results are shown in FIG. As is apparent from the figure, catecholamines such as adrenaline and noradrenaline increased after smelling pepper or grapefruit as compared to the scent presentation, and the scent of these fragrances activated sympathetic nerve activity. It became clear that secretion of catecholamines such as adrenaline and noradrenaline was promoted.

Example 3 FIG. Synergistic effect of catecholamines (noradrenaline) and caffeine When noradrenaline (0.5 μg / ml) was added to 70 mg subcutaneous tissue of 6-week-old rats, caffeine (1 mM) itself was uncoupled protein-3 as shown in FIG. However, when noradrenaline (0.5 μg / ml) and caffeine (1 mM) were added simultaneously, the expression of uncoupling protein-3 was synergistically increased.

Example 4 The slimming effect was confirmed using the emulsion of the emulsion (formulation example 5) described after the verification of the slimming effect by the continuous test . Twenty women aged 20 to 30 years used the milk on the body every day for a month, and compared changes in weight and surroundings (waist and hip 9) before and after the continuous test. It was as follows.

表１から明らかな通り、連用後、体重、ウエスト長及びヒップ長が有意に減少しており、本発明の痩身効果が確認された。

As apparent from Table 1, the weight, waist length and hip length were significantly reduced after continuous use, confirming the slimming effect of the present invention.

Formulation Examples In the formulation examples,% means mass%.
Fragrance (1) Alcohol 75%
(2) Purified water residue (3) Dipropylene glycol 5%
(4) 10% fragrance of the present invention
(5) Antioxidant appropriate amount (6) Grapefruit oil 5%
(7) Appropriate amount of dye (8) Appropriate amount of UV absorber

  Here, the “fragrance” is obtained by dissolving the grapefruit oil of the present invention in alcohol (for example, ethyl alcohol) or aqueous alcohol. The fragrance contains 1 to 99% by mass of the grapefruit oil of the present invention. The mixing ratio of water and alcohol is in the range of 50:50 to 0: 100. Fragrances can contain solubilizers, softeners, fumestanes, thickeners, bacteriostats, or other materials commonly used in cosmetics. Using normal scenting means, add fragrance ingredients that harmonize with the grapefruit oil of the present invention and modulate it, finish it with retention and body, or make top note, middle note, last note appropriately In combination, it is possible to prepare a formulation that emits an attractive fragrance over time.

  For example, an example of a blend that combines these essential oils that exhibit sympathetic nerve activity is the formulation shown in Fragrance Formulation Example 1. As a result of comparing the effects of this prescription fragrance on sympathetic nerve activity, a high sympathetic nerve activation effect was observed (FIG. 4).

Blended fragrance formulation example 1
(1) Grapefruit oil 200
(2) Linalool 20
(3) Linalyl acetate 10
(4) Pepper oil 100
(5) Fennel oil 20
(6) Estragon oil 10
(7) Sage oil 20
(8) Helional 20
(9) Manzanate 20
(10) Hedion 150
(11) Dihydromilsenol 50
(12) Garaxoride 50
(13) Bergamot oil 50
(14) Limonene 140
(15) Cis-3-hexenol 1
(16) Helional 2
(17) Allyl amyl glycolate 2
(18) Dipropylene glycol 135
Total 1000

Blended fragrance formulation examples 2 and 3
No. Fragrance Name Formulation Example 2 Formulation Example 3
(1) Grapefruit oil 10.0 5.0
(2) Estragon oil 32.0 30.0
(3) Fennel oil 8.0 1.0
(4) Pepper oil 0.1-
(5) Hyssop oil 0.1-
(6) Bergamot 1.0 −
(7) CIS-3-hexonol 2.0 0.7
(8) Cis-3-hexenyl acetate 1.0 0.3
(9) Triplar 2.0 0.7
(10) Tomato base 3.0 1.0
(11) Styraryl acetate 2.0 0.7
(12) Referrer 3.0 1.0
(13) Caron 1.0 1.0
(14) Linalool 10.0 10.0
(15) Benzyl acetate 1.0 1.0
(16) Hedion 0.5 0.5
(17) β-ionone 1.0 1.0
(18) Menthol 10.0 10.0
(19) Musk 1.0 5.0
(20) Triethyl citrate 11.3 31.1

Blended fragrance formulation examples 4 and 5
No. Fragrance Name Formulation Example 4 Formulation Example 5
(1) Grapefruit oil 200 200
(2) Linalool 20 20
(3) Linalyl acetate 10 20
(4) Pepper oil 100 20
(5) Fennel oil 20 10
(6) Estragon oil 10 10
(7) Sage oil 20 20
(8) Helional 20 −
(9) Manzanate 20 −
(10) Hedion 150 150
(11) Dihydromyrcenol 50 −
(12) Galaxoride 50 50
(13) Bergamot 50 50
(14) Limonene 140 140
(15) Cis-3-hexenol 1-
(16) Helional 2 −
(17) Allyl amyl glycolate 2-
(18) α-Hexylcinnamic aldehyde-40
(19) Phenylethyl alcohol-20
(20) Lilianal-20
(21) Rear -20
(22) β-ionone-20
(23) Methyl ionone γ-30
(24) Geraniol-30
(25) Citronellol-20
(26) Dimethylbenzylcarbonyl acetate-50
(27) Dipropylene glycol 135 70
Total 1,000 1,000

External preparation for skin (cosmetics)
As drugs, various extracts such as trimethylglycine, brown algae extract, red algae extract, green algae extract, tocopherol acetate, natto extract, dokudami extract, etc. and various drugs that can be used for skin external medicines such as dipotassium glycyrrhizinate I can do it.

Lotion (Formulation Example 1)
(1) Glycerin 2%
(2) Dipropylene glycol 2%
(3) PEG-60 hydrogenated castor oil 0.3%
(4) Trimethylglycine 0.1%
(5) Preservative appropriate amount (6) Chelating agent appropriate amount (7) Dye appropriate amount (8) Invention perfume appropriate amount (9) Purified water remaining amount

Lotion (Formulation Example 2)
(1) Alcohol 30%
(2) Butylene glycol 4%
(3) Glycerin 2%
(4) PPG-13 decyltetrades 24 0.3%
(5) Octyl methoxycinnamate 0.1%
(6) Menthol 0.2%
(7) Tocopherol acetate 0.1%
(8) Chelating agent appropriate amount (9) Dye appropriate amount (10) Perfume of the present invention Appropriate amount (11) Remaining amount of purified water

Emulsion (Formulation Example 1)
(1) Ethyl alcohol 10%
(2) Cyclomethicone 0.1%
(3) Butylene glycol 5%
(4) Dimethicone 3%
(5) Glycerin 0.1%
(6) Menthol 1%
(7) Trimethylsiloxysilicic acid 0.1%
(8) Caffeine 1%
(9) Trimethylglycine 1%
(10) Xanthan gum 0.001%
(11) Hydroxyethyl cellulose 0.1%
(12) Fermented soybean extract 1%
(13) Lauryl betaine 0.5%
(14) Brown algae extract 1%
(15) Red algae extract 1%
(16) Green algae extract 1%
(17) Carbomer 0.2%
(18) Chelating agent appropriate amount (19) Paraben appropriate amount (20) Benzoic acid appropriate amount (21) Perfume of the present invention (22) Iron oxide appropriate amount (23) Caustic potash 0.05%
(24) Dipotassium glycyrrhizinate 0.01%
(25) Pyridoxine hydrochloride 0.01%
(26) Ascorbic acid glucoside 0.01%
(27) Ascorbic acid 0.01%
(28) Arbutin 3%
(29) Yukinoshita extract 0.1%
(30) Water remaining

Emulsion (Formulation Example 2)
(1) Butylene glycol 4%
(2) Propylene glycol 4%
(3) Carbomer 0.2%
(4) Caustic potash 0.2%
(5) Behenic acid 0.5%
(6) Stearic acid 0.5%
(7) Isostearic acid 0.5%
(8) Glyceryl stearate 1%
(9) Glyceryl isostearate 1%
(10) Behenyl alcohol 0.5%
(11) 0.5% batyl alcohol
(12) Squalane 5%
(13) Trioctanoin 3%
(14) Phenyltrimethicone 2%
(15) Dipotassium glycyrrhizinate 0.01%
(16) Preservative appropriate amount (17) Chelating agent appropriate amount (18) Pigment appropriate amount (19) Perfume of the present invention (20) Purified water remaining

Emulsion (Formulation Example 3)
(1) Glycerin 3%
(2) Xylitol 2%
(3) Carbomer 0.1%
(4) Caustic potash 0.1%
(5) Glyceryl isostearate 1%
(6) Glyceryl stearate 0.5%
(7) Behenyl alcohol 1%
(8) 1% batyl alcohol
(9) Hardened palm oil 2%
(10) Vaseline 1%
(11) Squalane 5%
(12) Erythrityl octoate 3%
(13) 1% cyclomethicone
(14) Preservative appropriate amount (15) Chelating agent appropriate amount (16) Perfume remaining amount of the present invention (17) Purified water remaining amount (18) Tranexamic acid 1%
(19) Pantothenyl ethyl ether 0.5%
(20) Nicotinamide 0.1%
(21) Trehalose 0.1%
(22) Rosemary extract 0.1%
(23) Vitamin A 0.1%
(24) Ascorbic acid glycoside 0.001%
(25) 1% raspberry extract
(26) Ogon extract 0.001%
(27) Alum extract 0.01%

Emulsion (Formulation Example 4)
(1) Ethanol 2%
(2) Cyclomethicone 10%
(3) Glycerin 5%
(4) Dibutylene glycol 1%
(5) Dimethicone 1%
(6) Corn starch 4%
(7) Mineral oil 2%
(8) Trimethylsiloxysilicic acid 5%
(9) Polyethylene glycol 3%
(10) Menth lactate 0.1%
(11) PEG-60 hydrogenated castor oil 1%
(12) Aminopropyl dimethicone 1%
(13) Xanthan gum 0.01%
(14) Tocopherol acetate 0.01%
(15) Caffeine 0.1%
(16) Sodium hyaluronate 0.1%
(17) Xanthan gum 0.01%
(18) Fermented soybean extract 0.01%
(19) Hamamelis extract 0.01%
(20) Dokudami extract 0.01%
(21) Carbomer 0.3%
(22) Alkyl methacrylate copolymer 0.2%
(23) HEDTA appropriate amount (24) preservative appropriate amount (25) perfume of the present invention appropriate amount (26) pigment appropriate amount (27) caustic potash 0.15%
(28) Aminomethylpropanol 0.05%
(29) Water remaining

Emulsion (Formulation Example 5)
(1) Ethanol 15%
(2) Cyclomethicone 6%
(3) Butylene glycol 0.5%
(4) Dimethicone 1%
(5) Glycerol 1%
(6) Polyethylene glycol 1
(7) Lactic acid menthyl 1%
(8) Menthol 0.1%
(9) Trimethylsiloxysilicic acid 1%
(10) Caffeine 0.5%
(11) Trimethylglycine 0.1%
(12) Xanthan gum 0.1%
(13) Hydroxyethyl cellulose 0.1%
(14) Fermented soybean extract 0.01%
(15) Tocopherol acetate 0.05%
(16) Lauryl betaine 0.01%
(17) Brown algae extract 0.01%
(18) Dokudami extract 0.01%
(19) Red algae extract 0.01%
(20) Green algae extract 0.01%
(21) Cellulose powder 1%
(22) PEG-60 glyceryl isostearate 1%
(23) 1% isostearic acid
(24) Carbomer 0.1%
(25) Alkyl methacrylate alkyl copolymer 0.1%
(26) EDTA 0.1%
(27) Sodium metaphosphate 0.1%
(28) Phenoxyethanol 0.2%
(29) Paraben 0.2%
(30) Perfume of the present invention (Formulated perfume formulation example 1) 0.45
(31) Iron oxide (red) 0.02%
(32) Menthyl glyceryl ether 0.01%
(33) Water remaining

Cream (Formulation Example 1)
(1) Glycerin 10%
(2) Butylene glycol 5%
(3) Carbomer 0.1%
(4) Caustic potash 0.2%
(5) Stearic acid 2%
(6) Glyceryl stearate 2%
(7) Glyceryl isostearate 2%
(8) Vaseline 5%
(9) Stearyl alcohol 2%
(10) Behenyl alcohol 2%
(11) Palm hardened oil 2%
(12) Squalane 10%
(13) 4-methoxycalicylic acid K 3.0%
(14) Preservative appropriate amount (15) Chelating agent appropriate amount (16) Pigment appropriate amount (17) Perfume of the present invention Appropriate amount (18) Purified water remaining

Cream (formulation example 2)
(1) Glycerin 3%
(2) Dipropylene glycol 7%
(3) Polyethylene glycol 3%
(4) Glyceryl stearate 3%
(5) Glyceryl isostearate 2%
(6) Stearyl alcohol 2%
(7) Behenyl alcohol 2%
(8) Liquid paraffin 7%
(9) Cyclomethicone 3%
(10) Dimethicone 1%
(11) Octyl methoxycinnamate 0.1%
(12) Hyaluronic acid Na 0.05%
(13) Preservative appropriate amount (14) Chelating agent appropriate amount (15) Pigment appropriate amount (16) Perfume of the present invention Appropriate amount (17) Purified water remaining

Gel (1) Ethyl alcohol 10%
(2) Glycerin 5%
(3) Butylene glycol 5%
(4) Carbomer 0.5%
(5) Aminomethylpropanol 0.3%
(6) PEG-60 hydrogenated castor oil 0.3%
(7) Menthol 0.02%
(8) Preservative appropriate amount (9) Chelating agent appropriate amount (10) Perfume of the present invention Appropriate amount (11) Purified water remaining

Aerosol (Formulation Example 1)
(1) Glycerin 2%
(2) Dipropylene glycol 2%
(3) PEG-60 hydrogenated castor oil 0.3%
(4) HPPCD
(Hydroxypropyl β cyclodextrin) 1.0%
(5) Preservative appropriate amount (6) Chelating agent appropriate amount (7) Dye appropriate amount (8) Perfume of the present invention (9) Purified water remaining amount (10) Nitrogen gas 0.8%

Aerosol (Prescription Example 2)
(1) Alcohol 15%
(2) Butylene glycol 2%
(3) Glycerol 1%
(4) PPG-13 Decyltetrades 24 0.1%
(5) Silver supported zeolite powder 1.0%
(6) Chelating agent Appropriate amount (7) Dye Appropriate amount (8) Perfume of the present invention Appropriate amount (9) Remaining amount of purified water (10) LPG 40%

Aerosol (Prescription Example 3)
(1) Ethanol 60%
(2) Menthyl lactate 0.1%
(3) Sodium lactate 0.1%
(4) Tocopherol acetate 0.01%
(5) Lactic acid 0.01%
(6) Caffeine 0.01%
(7) fennel extract 1%
(8) Hamamelis extract 1%
(9) Dokudami extract 1%
(10) Dipropylene glycol 1%
(11) Nitrogen gas 0.9
(12) Polyoxyethylene polyoxypropylene decyl tetradecyl ether 1%
(13) Butylene glycol 2%
(14) Tocopherol 0.05%
(15) Appropriate perfume of the present invention (16) PEG-60 hydrogenated castor oil 0.1%
(17) Water remaining

Bath salt (1) Sodium sulfate 45.0%
(2) Sodium bicarbonate 45.0%
(3) Hyssop oil 10.0%
(4) The present perfume

Room fragrance (1) Alcohol 80.0%
(2) Purified water residue (3) Antioxidant 5.0%
(4) Perfume of the present invention Suitable amount (5) 3-methyl-3-methoxybutanol 5.0%
(6) Dibenzylidenesorbitol 5.0%
(7) Sage oil 5.0%

Incense (1) Tab powder 75.5%
(2) Sodium benzoate 15.5%
(3) Perfume amount of the present invention (4) Eucalyptus oil 1.0%
(5) Fennel oil 1.0%
(6) Purified water residue

Massage Gel (1) Erythritol 2.0%
(2) Caffeine 5.0%
(3) Awaku extract 3.0%
(4) Glycerin 50.0%
(5) Carboxyvinyl polymer 0.40%
(6) Polyethylene glycol 400 30.0%
(7) Ethylenediaminehydroxyethyl triacetate trisodium 0.1%
(8) Polyoxyethylene (10) methylpolysiloxane copolymer 2.0%
(9) Squalane 1.0%
(10) Fennel oil 1.0%
(11) Potassium hydroxide 0.15%
(12) Purified water residue

Foam pack (1) Caffeine 1.0%
(2) Sodium metaphosphate 0.02%
(3) Trehalose 2.0%
(4) Glycerin 7.0%
(5) Methylparaben 0.11%
(6) Potassium hydroxide 0.15%
(7) Stearic acid 0.5%
(8) Myristic acid 1.0%
(9) 1.5% batyl alcohol
(10) Polyoxyethylene (60) hydrogenated castor oil 3.0%
(11) Pepper oil 0.3%
(12) Liquefied petroleum gas 6.0%
(13) Dimethyl ether 3.0%
(14) Appropriate amount of the present invention fragrance (15) Purified water residue
The invention's effect

  ADVANTAGE OF THE INVENTION According to this invention, the sympathetic nerve activation composition without a side effect can be provided, Furthermore, the composition for slimming and the composition for memory improvement are provided.

FIG. 1 is a graph showing the sympathetic nerve relative activity by systolic blood pressure fluctuation analysis. FIG. 2 is a graph showing the sympathetic nerve relative activity by the systolic blood pressure fluctuation analysis. FIG. 3 is a graph showing the sympathetic nerve relative activity of the hot water extract of pepper. FIG. 4 is a graph showing the sympathetic nerve relative activity of the combination of the essential oils that have the effect of activating the sympathetic nerve (fragrance formulation 1). FIG. 5 is a graph showing the increase in blood catecholamines due to the sympathetic nerve activated fragrance. FIG. 6 is a graph showing the synergistic effect of caffeine and noradrenaline on the expression of uncoupling protein-3 gene in subcutaneous adipose tissue.

Claims (2)

  One or two selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olive nam A slimming composition comprising at least a seed and caffeine. Applying the composition according to claim 1 to the skin, fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, A slimming method in which one or more selected from ginger oil, geranium oil and olivenum are sniffed and caffeine is absorbed through the skin.

Images