JP2009235015A - Autonomic nerve regulator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To improve autonomic dystonia or sleep condition through sedative regulation of the autonomic nerves by suppressing the hyperactive sympathetic nerves or activating the parasympathetic nerves. <P>SOLUTION: At least one chosen from jasmin (Jasmin sambac) extract, 3-methyloctano-4-lactone, bornyl acetate and thyme (Thymus vulgaris) steam distillate is compounded as an active ingredient. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an autonomic nerve adjusting agent, and more particularly, to an autonomic nerve adjusting agent that suppresses sympathetic nerves or activates parasympathetic nerves to adjust the autonomic nerves statically.

  The modern society is said to be a stress society, and the balance of the autonomic nerves is lost due to various mental or physical stresses, and we suffer from various symptoms due to autonomic disorder such as insomnia, high blood pressure, headache, stiff shoulders, hot flashes and irritation. The number of people is increasing.

  The autonomic nerve is composed of a sympathetic nerve and a parasympathetic nerve, and both nerves have an action of antagonizing each other, and control most functions of the body such as internal organs, blood vessels, and secretory glands. The sympathetic nerve is a nerve that works to bring the mind and body into an active state. When the sympathetic nerve becomes dominant, the heart beats faster, blood vessels contract and blood pressure rises, and the mind and body become in an enhanced state. On the other hand, the parasympathetic nerve is a nerve that works to release the mind and body from tension and to rest (relax). When the parasympathetic nerve becomes dominant, the pulsation slows down, the blood vessels dilate, the blood pressure decreases, and the mind and body are sedated. It becomes. Under normal conditions, sympathetic nerves predominate during active time, parasympathetic nerves predominate during rest time, the balance of both nerves is properly adjusted to maintain homeostasis, and mental and physical health It is kept. However, due to various factors, the switching of both switches does not function well, the state of sympathetic nerves continues to increase, the balance of the autonomic nerves breaks down, the state of mind-body tension continues, sleeplessness and irritation, etc. Various symptoms occur due to ataxia.

  Aromatherapy has long been known to provide sedation and eliminate insomnia, and various studies have been conducted on the effects of fragrances on the autonomic nervous system. For example, Patent Document 1 describes that jasmine lactone has a sleep-stimulating action. Furthermore, Patent Document 2 describes that cedrol adjusts the autonomic nerve to bring about a sleep improvement effect, and Patent Document 3 adjusts the autonomic nerve to have a sleep improving effect. Are listed.

However, the sensitivity and palatability with respect to fragrances, such as fragrance | flavors reported conventionally, have a large individual difference, and the effect which can fully be satisfied is not acquired. Therefore, there is still a strong need for new substances that can more effectively and universally suppress enhanced sympathetic nerves or activate parasympathetic nerves to sedatively adjust autonomic nerves.
Japanese Patent Laid-Open No. 6-40911 International Publication No. 01/058435 Pamphlet JP 2007-197334 A

  In view of the circumstances as described above, the present invention provides a novel substance that can safely and effectively adjust the autonomic nerve and can effectively improve autonomic dysfunction or sleep state. It is the purpose.

  The present inventor has found that an extract of the pine mosquito (jasmin sambac), 3-methyloctano-4-lactone and bornyl acetate has a sympathetic inhibitory effect, and a thymus plant thyme (thymus vulgaris) steam distillate has a parasympathetic nerve activation effect, and all of them found that the autonomic nerve can be adjusted statically, and the present invention has been completed.

  The autonomic nervous regulator of the present invention is one or two selected from an extract of pine (jasmin sambac), 3-methyloctano-4-lactone, bornyl acetate, and a steam distillate of thymus vulgaris. The above is an effective ingredient. Extracts of pine (jasmin sambac), 3-methyloctano-4-lactone and bornyl acetate are sympathetic depressants, and thymus vulgaris steam distillate is a parasympathetic activator. The autonomic nerve can be adjusted statically.

  The agent for preventing or ameliorating autonomic dysfunction and the sleep improving agent of the present invention is an extract of pine (jasmin sambac), 3-methyloctano-4-lactone, bornyl acetate, and steam distillation of thymus vulgaris. One or more kinds selected from products are used as active ingredients. By suppressing the increased sympathetic nerves or activating the parasympathetic nerves, the parasympathetic nerves are adjusted to be more dominant than the sympathetic nerves, thereby improving various symptoms caused by autonomic dysfunction. In addition, the sleep state can be improved.

  The autonomic nerve regulator of the present invention has no side effects, and can adjust the autonomic nerve statically without being influenced by the sensitivity or preference of the individual, and the balance of the autonomic nerve is lost and the sympathetic nerve is in an overly dominant state. It can safely and effectively improve various symptoms caused by autonomic dysfunction such as insomnia, high blood pressure, headache, stiff shoulders, hot flashes, and irritation.

  The autonomic nerve adjusting agent, the preventive or improving agent for autonomic dystaxia, and the sleep improving agent (hereinafter referred to as autonomic nerve adjusting agent) of the present invention are extracts of pine (jasmin sambac), 3-methyloctano- One or more selected from 4-lactone, bornyl acetate, and thymus vulgaris steam distillate are included as active ingredients.

  In the present invention, “autonomous nerve adjustment” means to improve the autonomic nervous system malfunction, and in subjects whose sympathetic nerve activity is higher than usual, suppress sympathetic nerve activity or activate parasympathetic nerve activity. It is defined by observing the phenomenon to be caused. For example, the sympathetic nerve activity and the parasympathetic nerve activity are obtained using the “Fraclet ™ (Dainippon Sumitomo Pharma Co., Ltd.)” circulatory dynamics / autonomic nervous system activity analysis system to evaluate the autonomic nerve regulating action of each substance. can do.

  In the present invention, “prevention or amelioration of autonomic dysfunction” means preventing or reducing or alleviating the symptoms of autonomic dysfunction such as insomnia, high blood pressure, headache, stiff shoulders, hot flashes, and irritation. To do.

  Further, in the present invention, “sleep improvement” means improving sleep feeling such as good sleep, good awakening, and good sleep in a subject who recognizes poor sleep.

  The pine (jasmin sambac) is a plant belonging to the genus Sokei. The whole pine licorice, leaves, bark, branches, fruits or roots can be used as they are or after being pulverized, but it is particularly preferable to use flowers. The pine extract is more active than the extract obtained by further extracting and purifying the part of the extract as it is or after being dried and then cut into a suitable size or pulverized. Contains a high fraction (component). The extraction is performed by impregnation with a solvent at room temperature or in a heated state or by using a distillation method such as steam distillation in addition to solvent extraction performed using an extraction device such as a Soxhlet extractor. A supercritical extraction method performed in a critical state or a pressing method for obtaining an extract by pressing can be used, and a solvent-extracted method can be particularly preferably used.

  As the extraction solvent used for solvent extraction, either a polar solvent or a nonpolar solvent can be used, and these can also be mixed and used. For example, water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; tetrahydrofuran Linear and cyclic ethers such as diethyl ether; polyethers such as polyethylene glycol; halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride; hydrocarbons such as hexane, cyclohexane and petroleum ether; benzene and toluene Aromatic hydrocarbons such as; pyridines; supercritical carbon dioxide; oils, waxes, other oils, and the like. These can be used alone or in combination of two or more, and can be repeated by changing the solvent. In . Of these, ethanol, dipropylene glycol, propylene glycol, butylene glycol and the like are preferably used.

  Thymus vulgaris is a Labiatae plant. Whole grass, flowers, leaves, branches or roots can be used as they are or after being pulverized, but it is particularly preferable to use flowers. In the present invention, “steam distillate” refers to an essential oil obtained by steam distillation. The thyme steam distillate used in the present invention can be prepared by subjecting its part as it is or after it has been dried to a suitable size, or by pulverizing it, and subjecting it to ordinary steam distillation. Further, a fraction (component) having a higher activity obtained by further separation and purification is also included. For example, it can be prepared by blowing steam into freshly-grown thyme flowers or dried ones, cooling and collecting volatile components, and separating and collecting the oily part (essential oil).

  The extract of pine and the steam distillate of thyme may be further separated and purified. Examples of the separation and purification means include treatment of the extract with activated carbon, liquid-liquid distribution, column chromatography, liquid chromatography, gel filtration, and precision distillation. Etc.

  The 3-methyloctano-4-lactone and bornyl acetate used in the present invention can be synthesized by a known synthesis method, or commercially available products may be used.

  In the present invention, pine extract, 3-methyloctano-4-lactone, bornyl acetate and thyme steam distillate may be used singly or in combination of two or more. As long as the autonomic nervous regulator of the present invention contains the above-mentioned substances as active ingredients and can achieve the effects of the present invention, the form thereof is not particularly limited, and it can be in any form such as liquid, paste, gel, solid, etc. Can be used. In addition, any other component such as an arbitrary carrier, diluent, auxiliary agent and the like can be included as long as the effects of the present invention are not hindered.

  The autonomic nerve regulator of the present invention can suppress the enhanced sympathetic nerve or activate the parasympathetic nerve to sedatively adjust the autonomic nerve and has high safety. Therefore, the pharmaceutical, quasi-drug, cosmetic, food It can be applied to any use such as beverages. Moreover, since the said active ingredient can vaporize and can exhibit an effect, it is also possible to apply to clothing, miscellaneous goods, etc. The target to be blended with the autonomic nerve regulating agent or the like of the present invention may be anything as long as the active ingredient can be blended in a form that can be vaporized and inhaled, and is limited by its dosage form and product form. It is not something. Moreover, according to the kind of the target object, you may further include the arbitrary component normally contained in the target object other than the said active ingredient. Furthermore, you may use together other arbitrary chemical | medical agents, such as a chemical | medical agent which adjusts another autonomic nerve, and the autonomic-nerve regulator of this invention.

  For example, the product form in which the autonomic nervous regulator of the present invention is blended is not limited, and examples thereof include cosmetics, pharmaceuticals, quasi drugs, foods, beverages, and the like. Examples include powders, granules, aerosols, solids and gels.

  Cosmetics that are one of the particularly preferred embodiments include, but are not limited to, for example, perfume, eau de toilette, eau de cologne, cream, milky lotion, lotion, foundations, powdered white powder, lipstick, soap, shampoo / rinse, body Shampoos, body rinses, body powders, bath agents and the like can be mentioned.

  In addition, for example, for any miscellaneous goods such as fragrance, deodorant, aroma candle, incense, stationery, wallet, bag, shoes, etc., and for any clothing such as underwear, clothes, hats, stockings, socks, etc. Inventive autonomic nerve regulators and the like can be included. You may add the autonomic-nerve regulator of this invention, etc. to any of those raw materials or products.

  In addition, although various usage aspects, such as an autonomic nerve regulator of this invention, were illustrated, it is not limited to them, As long as the effect of this invention can be achieved, it can be used in arbitrary aspects.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to these. The solvent extract of matsurika was commercially available from Roberte Co., Ltd., and the thyme steam distillate was commercially available from Charabo Co., Ltd. Further, 3-methyloctano-4-lactone was commercially available from Iwata Fragrance Co., Ltd., and bornyl acetate was used from Takasago Fragrance Industry Co., Ltd.

Test Example 1 Examination of the effects on the autonomic nervous system Heartbeat intervals (beat intervals) and blood pressure fluctuate in a complex manner at rest, and are known as heartbeat fluctuations and blood pressure fluctuations, respectively. The pulsation interval is controlled by a plurality of systems represented by the sympathetic nervous system and the parasympathetic nervous system. As a result of each system having a different specific period, the pulsation interval changes in a complex manner. Therefore, it is possible to calculate the activity of each system by frequency analysis of the pulsation interval, HF (high frequency component) of heart rate fluctuation is parasympathetic nervous system activity, and LF (low frequency component) is sympathetic. Shows mixed activity of nervous system and parasympathetic nervous system. Further, blood pressure fluctuations (blood pressure fluctuations) are partially controlled by the sympathetic nervous system, and if the blood pressure fluctuations are subjected to frequency analysis, the sympathetic nervous system activity can be calculated as the LF (low frequency component). (Junichiro Hayano, Cardiology, 34, 347-356, 1993).

  Therefore, using an autonomic nervous system activity analysis system (Fraclet; manufactured by Dainippon Sumitomo Pharma Co., Ltd.), frequency analysis of fluctuations of pulsation interval (R wave interval, RR) and blood pressure (systolic blood pressure, SBP) is performed. Fluctuation HF (0.15 to 2 Hz high frequency component) is parasympathetic nerve activity (RR-HF), blood pressure fluctuation LF (0.04 to 0.15 Hz low frequency component) is sympathetic nerve activity (SBP-LF) The effects of substances on the autonomic nervous system were evaluated.

(1) Examination of influence on sympathetic nerve activity In a 20s female subject, a cotton piece soaked with a test sample was applied under the nose and inhaled with natural breathing to examine the influence on sympathetic nerve activity.

  The test was conducted in a constant temperature and humidity chamber having a temperature of 25 ° C. and a humidity of 50%. After the subject was seated in an easy chair and kept quiet for 30 minutes, a tonometer sensor was attached to the wrist and blood pressure was continuously measured. The blood pressure measured by the tonometer sensor was corrected by a cuff sphygmomanometer on the upper arm.

  The measurement test consists of (A) 3 minutes of rest, (B) 3 minutes by applying a non-scented cotton piece under the nose, (C) 3 minutes of rest, (D) Cotton piece in which the test sample is soaked under the nose. 3 minutes after applying (E) 3 minutes of rest, (F) 3 minutes after applying a piece of scented cotton under the nose, and (G) 3 minutes of rest. The blood pressure fluctuation was measured and frequency analysis was performed to calculate sympathetic nerve activity (SBP-LF).

The change of SBP-LF at the time of (D) which inhaled the test sample was investigated by using as a control the SBP-LF at the time of (B) and (F) to which a non-scented cotton piece was applied. That is,
SBP-LF ratio = SBP-LF (D) / (average value of SBP-LF (B) and SBP-LF (F))
When this SBP-LF ratio is smaller than 1, it means that the substance has suppressed sympathetic nerve activity, and when it is larger than 1, it means that sympathetic nerve activity has been enhanced.

  In addition, it evaluated similarly using the solvent extract of Sokei (jasmine) which belongs to the genus Solanumae as a control sample.

  The results are shown in FIG. When the scent of pine extract, 3-methyloctano-4-lactone or bornyl acetate was smelled, the SBP-LF ratio was lower than 1, indicating that the sympathetic nerve was suppressed. The inhibitory effect was significantly higher than that of jasmine.

(2) Examination of influence on parasympathetic nerve activity In a 20s female subject, a cotton piece soaked with a test sample was applied under the nose and inhaled with spontaneous breathing to examine the influence on parasympathetic nerve activity.

  The test was conducted in a constant temperature and humidity chamber having a temperature of 25 ° C. and a humidity of 50%. After keeping the subject at rest for 30 minutes, an electrode was attached to the chest and the electrocardiogram was continuously measured.

  The measurement test consists of (A) 3 minutes of rest, (B) 3 minutes by applying a non-scented cotton piece under the nose, (C) 3 minutes of rest, (D) Cotton piece in which the test sample is soaked under the nose. For 3 minutes, (E) 3 minutes for rest, (F) 3 minutes for a non-scented cotton piece attached to the nose, and (G) 3 minutes for rest. Was measured, frequency fluctuations were analyzed for fluctuations in the pulsation interval, and parasympathetic nerve activity (RR-HF) was calculated.

The change in RR-HF when the test sample was inhaled (D) was examined using the RR-HF at the time of (B) and (F) to which a non-scented cotton piece was applied as a control. That is,
RR-HF ratio = RR-HF (D) / (average value of RR-HF (B) and RR-HF (F))
When this RR-HF ratio is smaller than 1, it means that the substance has suppressed parasympathetic nerve activity, and when it is larger than 1, it means that parasympathetic nerve activity has been enhanced.

  In addition, it evaluated similarly using the steam distillate of the fruit (pepper) of the pepper which is a plant of the family Pepperaceae as a control sample.

  The results are shown in FIG. When the scent of thymus vulgaris steam distillate was smelled, the RR-HF ratio was greater than 1, indicating that the parasympathetic nerve was activated.

Test Example 2 Examination of effect on autonomic dysfunction symptoms The effect of improving autonomic dysfunction symptoms when using the present invention was examined.

  Four females in their twenties were subjects, and they were put to sleep while inhaling the scent of the present invention as room fragrances every night for about one month, and the intensity of symptoms before and after using the room fragrance was compared.

  The room fragrance was prepared by impregnating a non-woven fabric with triethyl citrate, a odorless solvent, so that the pine extract was 30% by weight, and putting it in a container.

  The subject's autonomic ataxia symptoms are the menstrual complications questionnaire (MDQ, Moos, RH, Psychosomatic Medicine, 30, 853-) that can measure both mental and physical complaints associated with the menstrual cycle and autonomic ataxia symptoms. 869, 1968).

  Using this questionnaire, the subjective symptoms of each subject in the late luteal phase were measured, and the symptoms of the luteal phase before using the room fragrance and the symptoms of the luteal phase after using it for one menstrual cycle (about 1 month) Compared.

  The results are shown in FIG. Compared with the use of fragrance, after the continuous use of the scent of pine extract, complaints such as cold sweat and hot face are significantly reduced, indicating that autonomic dysfunction symptoms are improved. It was.

  The following are typical examples of various compositions, sundry goods, clothing, etc., including the autonomic nerve regulator of the present invention, the agent for preventing or improving autonomic dystaxia, or the sleep improving agent (described as an autonomic nerve regulator in the following application examples). Application examples of typical product forms. In addition, all compounding quantities are represented by the mass% with respect to the product whole quantity. In addition, as an autonomic nervous regulator of the present invention, a squid extract, thyme steam distillate, 3-methyloctano-4-lactone or bornyl acetate was added alone or in combination.

Application example 1
Lotion (1) Glycerin 2.0
(2) Dipropylene glycol 2.0
(3) PEG-60 hydrogenated castor oil 0.3
(4) Trimethylglycine 0.1
(5) Preservative appropriate amount (6) chelating agent appropriate amount (7) dye appropriate amount (8) autonomic nervous regulator (bornyl acetate) 0.05
(9) Purified water residue

Application example 2
Lotion (1) Alcohol 30.0
(2) Butylene glycol 4.0
(3) Glycerin 2.0
(4) PPG-13 decyltetrades 24 0.3
(5) Octylmethoxycinnamate 0.1
(6) Menthol 0.2
(7) Tocopherol acetate 0.1
(8) Chelating agent appropriate amount (9) Dye appropriate amount (10) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.01
(11) Purified water residue

Application example 3
Emulsion (1) Stearic acid 2.0
(2) Cetyl alcohol 1.5
(3) Vaseline 4.0
(4) Squalane 5.0
(5) Glycerol tri-2-ethylhexanoate 2.0
(6) Sorbitan monooleate 2.0
(7) Dipropylene glycol 5.0
(8) PEG 1500 0.3
(9) Triethanolamine 0.1
(10) Preservative appropriate amount (11) Autonomic nerve regulator (3-methyloctano-4-lactone) 0.2
(12) Purified water residue

Application example 4
Latex (1) Ethyl alcohol 10.0
(2) Cyclomethicone 0.1
(3) Butylene glycol 5.0
(4) Dimethicone 3.0
(5) Glycene 0.1
(6) Menthol 1.0
(7) Trimethylsiloxysilicic acid 0.1
(8) Caffeine 1.0
(9) Trimethylglycine 1.0
(10) Xanthan gum 0.001
(11) Hydroxyethyl cellulose 0.1
(12) Fermented soybean extract 1.0
(13) Lauryl betaine 0.5
(14) Carbomer 0.2
(15) Chelating agent appropriate amount (16) Paraben appropriate amount (17) Benzoic acid appropriate amount (18) Autonomic nerve regulator (bornyl acetate) 0.02
(19) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.08

(20) Iron oxide appropriate amount (21) Caustic potash 0.05
(22) Dicalcium glycyrrhizinate 0.01
(23) Pyridoxine hydrochloride 0.01
(24) Ascorbic acid glucoside 0.01
(25) Arbutin 3.0
(26) Yukinoshita extract 0.1
(27) Water residue

Application example 5
Emulsion (1) Butylene glycol 4.0
(2) Propylene glycol 4.0
(3) Carbomer 0.2
(4) Caustic potash 0.2
(5) Behenic acid 0.5
(6) Stearic acid 0.5
(7) Isostearic acid 0.5
(8) Glyceryl stearate 1.0
(9) Glyceryl isostearate 1.0
(10) Behenyl alcohol 0.5
(11) Squalane 5.0
(12) Trioctanoin 3.0
(13) Phenyltrimethicone 2.0
(14) Batyl alcohol 0.5
(15) Dicalcium glycyrrhizinate 0.01
(16) Preservative Appropriate amount (17) Chelating agent Appropriate amount (18) Pigment Appropriate amount (19) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.15
(20) Purified water residue

Application Example 6
Latex (1) Glycerol 3.0
(2) Xylitol 2.0
(3) Carbomer 0.1
(4) Caustic potash 0.1
(5) Glyceryl isostearate 1.0
(6) Glyceryl stearate 0.5
(7) Behenyl alcohol 1.0
(8) Batyl alcohol 1.0
(9) Hardened palm oil 2.0
(10) Vaseline 1.0
(11) Squalane 5.0
(12) Erythrityl octoate 3.0
(13) Cyclomethicone 1.0
(14) Preservative appropriate amount (15) Chelating agent appropriate amount (16) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.2
(17) Purified water Residual (18) Tranexamic acid 1.0
(19) Pantothenyl ethyl ether 0.5
(20) Nicotinamide 0.1
(21) Trehalose 0.1
(22) Rosemary extract 0.1
(23) Vitamin A 0.1
(24) Ascorbic acid glycoside 0.001
(25) Raspberry extract 1.0
(26) Ogon extract 0.001
(27) Oat extract 0.01

Application example 7
Emulsion (1) Ethanol 2.0
(2) Cyclomethicone 10.0
(3) Glycerin 5.0
(4) Dibutylene glycol 1.0
(5) Dimethicone 1.0
(6) Cornstarch 4.0
(7) Mineral oil 2.0
(8) Trimethylsiloxysilicic acid 5.0
(9) Polyethylene glycol 3.0
(10) Lactic acid menthyl 0.1
(11) PEG-60 hydrogenated castor oil 1.0
(12) Aminopropyl dimethicone 1.0
(13) Xanthan gum 0.01
(14) Tocopherol acetate 0.01
(15) Caffeine 0.1
(16) Sodium hyaluronate 0.1
(17) Fermented soybean extract 0.01
(18) Hamamelis extract 0.01
(19) Dokudami Extract 0.01
(20) Carbomer 0.3
(21) Matacrylic acid alkyl copolymer 0.2
(22) EDTA appropriate amount (23) antiseptic appropriate amount (24) autonomic nervous regulator (extract of pine (jasmin sambac)) 0.15
(25) Autonomic nerve regulator (3-methyloctano-4-lactone) 0.15
(26) Pigment appropriate amount (27) Caustic potash 0.15
(28) Aminomethylpropanol 0.05
(29) Water residue

Application example 8
Latex (1) Ethanol 15.0
(2) Cyclomethicone 6.0
(3) Butylene glycol 0.5
(4) Dimethicone 1.0
(5) Glycerin 1.0
(6) Polyethylene glycol 1.0
(7) Lactic acid menthyl 1.0
(8) Menthol 0.1
(9) Trimethylsiloxysilicic acid 1.0
(10) Caffeine 0.5
(11) Trimethylene glycine 0.1
(12) Xanthan gum 0.1
(13) Hydroxyethyl cellulose 0.1
(14) Fermented soybean extract 0.01
(15) Tocopherol acetate 0.05
(16) Lauryl betaine 0.01
(17) Brown algae extract 0.01
(18) Dokudami extract 0.01
(19) Red algae extract 0.01
(20) Green algae extract 0.01
(21) Cellulose powder 1.0
(22) PEG-60 glyceryl isostearate 1.0
(23) Isostearic acid 1.0
(24) Carbomer 0.1
(25) Alkyl methacrylate alkyl polymer 0.1
(26) EDTA 0.1
(27) Sodium metaphosphate 0.1
(28) Phenoxyethanol 0.2
(29) Paraben 0.2
(30) Autonomic nerve regulator (3-methyloctano-4-lactone) 0.2
(31) Autonomic nerve regulator (bornyl acetate) 0.1
(32) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.15
(33) Iron oxide (red) 0.02
(34) Menthyl glyceryl ether 0.01
(35) Water residue

Application example 9
Cream (1) Glycerin 10.0
(2) Butylene glycol 5.0
(3) Carbomer 0.1
(4) Caustic potash 0.2
(5) Stearic acid 2.0
(6) Glyceryl stalate 2.0
(7) Glyceryl isostearate 2.0
(8) Vaseline 5.0
(9) Preservative appropriate amount (10) Antioxidant appropriate amount (11) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.3
(12) Purified water Residual (13) Chelating agent Appropriate amount (14) Pigment Appropriate amount (15) Stearyl alcohol 2.0
(16) Behenyl alcohol 2.0
(17) Palm hardened oil 2.0
(18) Squalane 10.0
(19) Potassium 4-methoxysalicylate 3.0

Application Example 10
Cream (1) Glycerin 3.0
(2) Dipropylene glycol 7.0
(3) Polyethylene glycol 3.0
(4) Glyceryl stearate 3.0
(5) Glyceryl isostearate 2.0
(6) Stearyl alcohol 2.0
(7) Behenyl alcohol 2.0
(8) Liquid paraffin 7.0
(9) Cyclomethicone 3.0
(10) Dimethicone 1.0
(11) Octyl methoxycinnamate 0.1
(12) Na hyaluronate 0.05
(13) Preservative appropriate amount (14) Antioxidant appropriate amount (15) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.3
(16) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.1
(17) Purified water Residual (18) Chelating agent appropriate amount (19) Pigment appropriate amount

Application Example 11
Gel (1) Ethyl alcohol 10.0
(2) Glycerin 5.0
(3) Butylene glycol 5.0
(4) Carbomer 0.5
(5) Aminomethylpropanol 0.3
(6) PEG-60 hydrogenated castor oil 0.3
(7) Menthol 0.02
(8) Preservative appropriate amount (9) chelating agent appropriate amount (10) autonomic nervous regulator (3-methyloctano-4-lactone) 0.1
(11) Purified water residue

Application Example 12
Aerosol (1) Glycerin 2.0
(2) Dipropylene glycol 2.0
(3) PEG-60 hydrogenated castor oil 0.3
(4) HPCCD 1.0
(5) Preservative appropriate amount (6) chelating agent appropriate amount (7) dye appropriate amount (8) autonomic nervous regulator (bornyl acetate) 0.2
(9) Purified water appropriate amount (10) LPG remaining

Application Example 13
Aerosol (1) Alcohol 15.0
(2) Butylene glycol 2.0
(3) Glycerin 1.0
(4) PPG-13 decyltetrades 24 0.1
(5) Silver supported zeolite 1.0
(6) Chelating agent appropriate amount (7) Dye appropriate amount (8) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.1
(9) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.1
(10) Purified water Residual (11) LPG 40.0

Application Example 14
Aerosol (1) Ethanol 60.0
(2) Lactic acid menthyl 0.1
(3) Sodium lactate 0.1
(4) Tocopherol acetate 0.01
(5) Lactic acid 0.01
(6) Caffeine 0.01
(7) Fennel extract 1.0
(8) Hamelis Extract 1.0
(9) Dokudami Extract 1.0
(10) Dipropylene glycol 1.0
(11) Nitrogen gas 0.9
(12) Polyoxyethylene polyoxypropylene 1.0
Decyl tetradecyl ether
(13) Butylene glycol 2.0
(14) Tocopherol 0.05
(15) Autonomic nerve regulator (3-methyloctano-4-lactone) 0.1
(16) Autonomic nerve regulator (bornyl acetate) 0.1
(17) PEG-60 hydrogenated castor oil 0.1
(18) Water residue

Application Example 15
Shampoo (1) Lauryl polyethylene (3)
Sulfate sodium salt (30% aqueous solution) 30.0
(2) Sodium lauryl sulfate ester salt (30% aqueous solution) 10.0
(3) Palm oil fatty acid diethanolamide 4.0
(4) Glycerin 1.0
(5) Preservative appropriate amount (6) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.5
(7) Dye appropriate amount (8) sequestering agent, pH adjuster appropriate amount (9) purified water residue

Application Example 16
Rinse (1) Silicone oil 3.0
(2) Liquid paraffin 1.0
(3) Cetyl alcohol 1.5
(4) Stearyl alcohol 1.0
(5) Stearyltrimethylammonium chloride 0.7
(6) Glycerin 3.0
(7) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.5
(8) Pigments and preservatives appropriate amount (9) Purified water residue

Application Example 17
Body shampoo (1) Lauric acid 2.5
(2) Myristic acid 5.0
(3) Palmitic acid 2.5
(4) Oleic acid 2.5
(5) Cocoyl diethanolamide 1.0
(6) Glycerin 20.0
(7) Caustic potash 3.6
(8) Dye appropriate amount (9) Autonomic nerve regulator (bornyl acetate) 0.5
(10) metal ion sequestering agent appropriate amount (11) purified water residue

Application Example 18
Fragrance (1) Alcohol 75.0
(2) Purified water Residual (3) Dipropylene glycol 5.0
(4) Autonomic nerve regulator (extract of pine (jasmin sambac)) 2.0
(5) Autonomic nerve regulator (3-methyloctano-4-lactone) 4.0
(6) Autonomic nerve regulator (bornyl acetate) 3.0
(7) Autonomic nerve modifier (thymus vulgaris steam distillate) 1.0
(8) Antioxidant 8.0
(9) Dye proper amount (10) UV absorber proper amount

Here, the “fragrance” is obtained by dissolving an essential oil in alcohol (for example, ethyl alcohol) or aqueous alcohol. The fragrance contains 1% to 99% by mass of essential oil. The mixing ratio of water and alcohol is in the range of 50:50 to 0: 100. Fragrances can contain solubilizers, softeners, fumestanes, thickeners, bacteriostats, or other materials commonly used in cosmetics.

Application Example 19
Room Fragrance (1) Alcohol 80.0
(2) Purified water Residue (3) Antioxidant 5.0
(4) Autonomic nerve regulator (bornyl acetate) 1.0
(5) Autonomic nerve modifier (thymus vulgaris steam distillate) 0.5
(6) 3-Methyl-3methoxybutanol 5.0
(7) Dibenzylidenesorbitol 5.0

Application Example 20
Incense (1) Tab powder 75.5
(2) Sodium benzoate 15.5
(3) Autonomic nerve regulator (extract of pine (jasmin sambac)) 5.0
(4) Eucalyptus oil 1.0
(5) Fennel oil 1.0
(6) Purified water residue

Application Example 21
Bath salt (1) Sodium sulfate 45.0
(2) Sodium bicarbonate 45.0
(3) Hyssop oil 9.0
(4) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.2
(5) Autonomic nerve regulator (3-methyloctano-4-lactone) 0.8

Application Example 22
Massage Gel (1) Erythritol 2.0
(2) Caffeine 5.0
(3) Oat extract 3.0
(4) Glycerin 50.0
(5) Carboxyvinyl polymer 0.4
(6) Polyethylene glycol 400 30.0
(7) edet trisodium 0.1
(8) Polyoxylene (10) Methyl polysiloxane copolymer 2.0
(9) Squalane 1.0
(10) Potassium hydroxide 0.15
(11) Autonomic nerve modifier (thymus vulgaris steam distillate) 1.0

Application Example 23
Massage cream (1) Solid paraffin 5.0
(2) Beeswax 10.0
(3) Vaseline 15.0
(4) Liquid paraffin 41.0
(5) 1.3-butylene glycol 4.0
(6) Glycerol monostearate 2.0
(7) POE (20) sorbitan monolaurate 2.0
(8) Borax 0.2
(9) Caffeine 2.0
(10) Preservative appropriate amount (11) Antioxidant appropriate amount (12) Autonomic nerve regulator (3-methyloctano-4-lactone) 1.0
(13) Purified water residue

Application Example 24
Aromatic fiber A microcapsule (particle size) in which the autonomic nerve regulator (bornyl acetate) of the present invention is encapsulated in a cuproammonium cellulose solution (cellulose concentration 10% by weight, ammonium concentration 7% by weight, copper concentration 3.6% by weight) 50 μm or less, the proportion of the essential oil in the microcapsule is 50 wt%) within a range of 0.1 to 20 wt% with respect to the cellulose weight, and after mixing, spinning according to a normal wet spinning method, An aromatic fiber was obtained through a drying process.

Application Example 25
Granule (1) Sucralose 0.1
(2) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.1
(3) Flavoring 5.0
(4) Excipient (Theolus) 10.0
(5) Maltitol residual

Application Example 26
Tablet (chewable type)
(1) Inositol 11.0
(2) Maltitol 21.0
(3) Sucrose 0.5
(4) White coconut extract (DNA Na) 0.1
(5) Yeast extract 0.1
(6) Autonomic nerve regulator (thymus vulgaris steam distillate) 0.1
(7) Flavoring 5.0
(8) Excipient residue

Application Example 27
Tablet (1) Lubricant (sucrose fatty acid ester, etc.) 1.0
(2) Gum arabic aqueous solution (5%) 2.0
(3) Acidulant 1.0
(4) Coloring agent appropriate amount (5) Autonomic nerve regulator (3-methyloctano-4-lactone) 0.1
(6) Carbohydrate (such as powdered sugar or sorbitol)

Application Example 28
Candy (1) Sugar 50.0
(2) Minamata 47.95
(3) Organic acid 2.0
(4) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.02
(5) Autonomic nerve regulator (bornyl acetate) 0.01
(6) Autonomic nervous regulator (thymus vulgaris steam distillate) 0.02

Application Example 29
Gum (1) Sugar 43.0
(2) Gum base 30.95
(3) Glucose 10.0
(4) Minamata 16.0
(5) Autonomic nerve regulator (extract of pine (jasmin sambac)) 0.05

  Various compositions, miscellaneous goods, clothing, etc. of these application examples can improve symptoms of autonomic dysfunction and sleep state by use test in typical usage of each product form. It was.

The graph which shows the influence with respect to a sympathetic nerve activity. The graph which shows the influence with respect to parasympathetic nerve activity. The graph which shows the influence with respect to an autonomic ataxia symptom.

Claims (5)

Autonomic nerve control with one or more active ingredients selected from pine (jasmin sambac) extract, 3-methyloctano-4-lactone, bornyl acetate, and thymus vulgaris steam distillate Agent. A sympathetic nerve inhibitor comprising as an active ingredient one or more selected from an extract of pine (jasmin sambac), 3-methyloctano-4-lactone and bornyl acetate. A parasympathomimetic agent containing thymus vulgaris steam distillate as an active ingredient. Autonomic dysfunction with one or more active ingredients selected from pine (jasmin sambac) extract, 3-methyloctano-4-lactone, bornyl acetate, and thymus vulgaris steam distillate Preventive or ameliorating agent. Sleep improver comprising as an active ingredient one or more selected from extracts of pine (jasmin sambac), 3-methyloctano-4-lactone, bornyl acetate, and thymus vulgaris steam distillate .

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