WO2006006282A1 - Composition sedative - Google Patents

Composition sedative Download PDF

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Publication number
WO2006006282A1
WO2006006282A1 PCT/JP2005/006390 JP2005006390W WO2006006282A1 WO 2006006282 A1 WO2006006282 A1 WO 2006006282A1 JP 2005006390 W JP2005006390 W JP 2005006390W WO 2006006282 A1 WO2006006282 A1 WO 2006006282A1
Authority
WO
WIPO (PCT)
Prior art keywords
lavender
sedative
distilled water
composition
steam
Prior art date
Application number
PCT/JP2005/006390
Other languages
English (en)
Japanese (ja)
Inventor
Tsuyoshi Sakamoto
Original Assignee
Kobayashi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co., Ltd. filed Critical Kobayashi Pharmaceutical Co., Ltd.
Publication of WO2006006282A1 publication Critical patent/WO2006006282A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a sedative composition. More specifically, the present invention relates to a sedative composition having a sedative effect.
  • Patent Document 1 Japanese Patent Laid-Open No. 11-343497
  • an object of the present invention is to provide a composition for sedation that is excellent in the action of calming the mind!
  • the present invention provides the following inventions:
  • Item 1 A sedative composition containing lavender steam distilled water.
  • Item 2 The sedative composition according to Item 1, wherein the lavender steam-distilled water is obtained from the above-ground part of the lavender or the whole plant power.
  • Item 3 The sedative composition according to Item 1 or 2, wherein the lavender is Okamurasaki or an improved variety thereof.
  • the “sedative composition” is used for calming, relaxing, or inducing a sleep of a human or animal.
  • the sedative composition of the present invention is characterized by containing lavender steam distilled water.
  • Lavender is a plant species belonging to the family Labiatae and Lavandula, and is an authentic lavender (scientific name; Lavandula).
  • the type of lavender to be used is not particularly limited.
  • Particularly preferred examples include various varieties such as Okamurasaki, Hanamoiwa, dark purple early bloom, and Yodei, and most preferred are Okamurasaki or improved varieties thereof, particularly those from Hokkaido, Japan.
  • Lavender may be wild or cultivated.
  • a raw material of steam distilled water of lavender lavender flowers, spikes, fruits, pericarp, stems, leaves, branches, branches and leaves, stems, crusts, rhizomes, root barks, seeds, either alone or in combination
  • the raw material of lavender steam-distilled water is preferably the above-ground part (whole plant excluding roots) or whole grass.
  • Lavender steam distilled water 0.6 to 2 parts by weight of water with respect to 1 part by weight of lavender, Preferably, it is prepared by performing steam distillation using 0.8 to 1 part by weight and collecting the aqueous phase of the collected distillate.
  • the method for steam distillation is not particularly limited, but a pressurized steam distillation method is preferable.
  • the sedative composition of the present invention may be composed only of lavender steam distilled water, but contains other components such as a carrier, a substrate or an additive depending on the form of use. You may do it.
  • the blending ratio of lavender steam distilled water in the sedation composition of the present invention varies depending on the use form of the composition, expected effects, etc., and cannot be specified uniformly, but as an example, Lavender water-distilled water is 0.01 to 100% by weight relative to the total weight. / 0 , preferably 1 to: L00 wt%, more preferably 10 to 100 wt%.
  • the shape of the sedative composition of the present invention may be in any form such as liquid, gel, solid, jewel, paste, and sheet. What is necessary is just to set suitably according to the intended purpose.
  • the sedative composition of the present invention can be used by supporting a nonwoven fabric, a sheet, a film, or the like as a carrier (holding body).
  • the carrier material for carrying the sedative composition of the present invention is not particularly limited.
  • natural fibers such as pulp, cotton, wool, hemp and silk
  • polypropylene, polyethylene, polyamide, polyethylene terephthalate, Synthetic fibers such as ribylene terephthalate, polysulfone, rayon, methacrylic acid resin, and glass fiber
  • porous materials such as zeolite, talc, white carbon, diatomaceous earth, lime, silica gel, and activated charcoal.
  • the form of the sedative composition of the present invention is not limited as long as lavender steam distilled water is volatilized and aroma is exhibited.
  • the form of the sedative composition of the present invention one used in a mode in which lavender steam-distilled water is evaporated or volatilized in an indoor space can be mentioned.
  • a soothing composition include products such as aroma candles and indoor fragrances.
  • the steam distilled water of lavender is evaporated in the space, and the effect of calming the mind can be given to the person or pet existing in the space.
  • cosmetic forms such as lotion, emulsion, cream, ointment, lotion, oil, knock, foundation, lipstick, scarlet, bath preparation Is mentioned.
  • the sedative composition of the present invention may be in the form of an external preparation for skin (external medicine or quasi drug).
  • the sedative composition of the present invention includes, for example, bedding such as futons and pillows; clothing; curtains; doors; screen doors; Those used in an embodiment in which steam distilled water is sprayed or applied.
  • bedding such as futons and pillows
  • clothing curtains
  • doors screen doors
  • the components of the lavender steam-distilled water are volatilized from the daily necessities to which the sedative composition is adhered, thereby producing an excellent sedative effect.
  • Examples of such forms include spray preparations, aerosol preparations, liquid, gel or cream preparations, and those obtained by impregnating them with a nonwoven fabric or the like.
  • the sedative composition of the present invention uses lavender steam distilled water, which is a natural component, and has high safety, so that it is volatilized in the space and applied or sprayed to daily necessities. It can be applied directly to human skin as a simple cosmetic.
  • the sedative composition of the present invention has an excellent sedative effect in addition to an excellent sedative effect, it is also useful as a composition for inducing sleep or a composition for sedative sleep. Suitable for people with insomnia and poor sleep.
  • steam-distilled water from which the above-ground part of lavender or the whole plant power can be obtained has a particularly prominent sleep / sedation effect, and a sedative composition containing the steam-distilled water is extremely useful.
  • FIG. 1 is a diagram showing the results (chromatograph) of lavender steam distilled water obtained in Example 1 analyzed by gas chromatography.
  • Example 1 With the paper (40 mm long, 40 mm wide, 5 mm thick) impregnated with about 4 g of lavender steam distilled water obtained in Example 1 installed on the monitor of a desktop personal computer at the office desk, Three subjects (Subjects 1 to 3) Force The task of inputting simple numerical data into a computer was performed for 15 minutes, and the accuracy of the task (input correct answer rate) and worker fatigue were evaluated. As a comparison, one 30-year-old subject (subject 4) used water instead of the lavender's steam distilled water to perform the same personal computer input work as above. We evaluated the feasibility (input correct answer rate) and worker fatigue. At the same time the day before the above test, subjects 1 to 4 performed the same personal computer input work using water instead of lavender steam distilled water, and the result was used as a control console. . Specifically, the evaluation was performed according to the following criteria.
  • Example 1 We also randomly selected three adults with poor sleep or adult insomnia. 350 ml of the lavender steam distilled water obtained in Example 1 is put in a known volatile liquid volatilization container, this is placed at the bedside, and the above three subjects sleep at this state. The effect of the composition on sleep was evaluated. The evaluation was performed according to the following evaluation criteria for (1) falling asleep, (2) depth of sleep, (3) awakening during sleep, and (4) state of awakening.
  • Table 2 shows the results obtained. As a result, it was confirmed that the sedative composition of the present invention has an excellent sleep promoting effect and a sleep inducing effect.
  • the numbers in the table indicate the number of people.
  • Example 2 We also randomly selected three adults with poor sleep or adult insomnia. 50 ml of the lavender steam-distilled water obtained in Example 1 was added to a water bath containing about 200 L of hot water. The above three subjects soaked in this bathtub for about 5 minutes and then went to sleep within 30 minutes. The sleepiness at that time was evaluated according to the following evaluation criteria.
  • the numbers in the table indicate the number of people.
  • the lavender steam distilled water and lavender essential oil obtained in Example 1 were subjected to component analysis by gas chromatography.
  • the lavender essential oil to be analyzed the oil phase in which the distillate power produced by steam distillation was recovered in Example 1 was used.
  • 47.5 g of lavender steam distilled water obtained in Example 1 was mixed with 2.5 g of hexane, and the lavender essential oil diluted to 1% by weight with methanol was used as samples. .
  • the analysis conditions are as follows. ⁇ Analysis conditions>
  • FID hydrogen flame ionization
  • Figure 1 shows the chromatograph obtained for lavender steam distilled water
  • Figure 2 shows the chromatograph obtained for Lavender mono essential oil. The peak patterns are different between Fig. 1 and Fig. 2, and it was confirmed that the composition of lavender steam distilled water and lavender essential oil differ.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • Medical Informatics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Composition sédative très efficace comme tranquillisant. L’eau distillée obtenue par distillation à la vapeur de lavande présente d’excellentes propriétés tranquillisantes et permet de bien dormir. L’eau distillée est utilisée pour préparer une composition sédative.
PCT/JP2005/006390 2004-09-30 2005-03-31 Composition sedative WO2006006282A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004-289176 2004-09-30
JP2004289176A JP2006104073A (ja) 2004-09-30 2004-09-30 鎮静用組成物

Publications (1)

Publication Number Publication Date
WO2006006282A1 true WO2006006282A1 (fr) 2006-01-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/006390 WO2006006282A1 (fr) 2004-09-30 2005-03-31 Composition sedative

Country Status (2)

Country Link
JP (1) JP2006104073A (fr)
WO (1) WO2006006282A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01185267A (ja) * 1988-01-19 1989-07-24 Geran Kaihatsu Kenkyusho:Kk 新吸入器
JPH06165619A (ja) * 1992-09-16 1994-06-14 Hokkaido Nogyo Shikenjo ラベンダー切り花の鮮度保持方法
JP2000212589A (ja) * 1999-01-20 2000-08-02 Cosmo Ace:Kk 植物精油含有水溶液およびその製造方法
JP2003192568A (ja) * 2001-12-27 2003-07-09 Nonogawa Shoji Kk 芳香化粧料組成物
JP2004238299A (ja) * 2003-02-04 2004-08-26 Ichimaru Pharcos Co Ltd 植物由来水蒸気蒸留水含有化粧料組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01185267A (ja) * 1988-01-19 1989-07-24 Geran Kaihatsu Kenkyusho:Kk 新吸入器
JPH06165619A (ja) * 1992-09-16 1994-06-14 Hokkaido Nogyo Shikenjo ラベンダー切り花の鮮度保持方法
JP2000212589A (ja) * 1999-01-20 2000-08-02 Cosmo Ace:Kk 植物精油含有水溶液およびその製造方法
JP2003192568A (ja) * 2001-12-27 2003-07-09 Nonogawa Shoji Kk 芳香化粧料組成物
JP2004238299A (ja) * 2003-02-04 2004-08-26 Ichimaru Pharcos Co Ltd 植物由来水蒸気蒸留水含有化粧料組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUCHBAUER G. ET AL.: "Aromatherapy: evidence for sedative effects of the essential o", BIOSCIENCES, vol. 46, no. 11-12, 1991, pages 1067 - 1072, XP002989855 *
PLOTTO A. ET AL: "Aroma quality of lavender water: a comparative study.", PERFUMER&FLAVORIST., vol. 26, no. 3, 2001, pages 44 - 64, XP002989847 *
VALLEE R. ET AL: "Natural plant extracts bring a new dimension to cosmetics by awakening the sensation of relaxation and well-being.", FRAGR.J., vol. 31, no. 11, 2003, pages 47 - 54, XP002989854 *

Also Published As

Publication number Publication date
JP2006104073A (ja) 2006-04-20

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