WO2005102150A1 - Procede de mesure de la pression, dispositif de mesure de la pression et tonometre - Google Patents

Procede de mesure de la pression, dispositif de mesure de la pression et tonometre Download PDF

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Publication number
WO2005102150A1
WO2005102150A1 PCT/JP2005/004916 JP2005004916W WO2005102150A1 WO 2005102150 A1 WO2005102150 A1 WO 2005102150A1 JP 2005004916 W JP2005004916 W JP 2005004916W WO 2005102150 A1 WO2005102150 A1 WO 2005102150A1
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WO
WIPO (PCT)
Prior art keywords
pressure
measured
contact
vibration
current value
Prior art date
Application number
PCT/JP2005/004916
Other languages
English (en)
Japanese (ja)
Inventor
Makoto Nakai
Sunao Takeda
Akihiko Uchiyama
Kenji Yanashima
Akihiro Fujita
Itaru Yoshizawa
Original Assignee
Waseda University
Kowa Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waseda University, Kowa Company, Ltd. filed Critical Waseda University
Priority to EP05721103A priority Critical patent/EP1738681A4/fr
Priority to US11/578,910 priority patent/US7713197B2/en
Publication of WO2005102150A1 publication Critical patent/WO2005102150A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L9/00—Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
    • G01L9/0001—Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means
    • G01L9/0008—Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means using vibrations
    • G01L9/0022—Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means using vibrations of a piezoelectric element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051—Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L11/00—Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group G01L7/00 or G01L9/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L9/00—Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
    • G01L9/0041—Transmitting or indicating the displacement of flexible diaphragms
    • G01L9/008—Transmitting or indicating the displacement of flexible diaphragms using piezoelectric devices

Definitions

  • Pressure measuring method pressure measuring device, and tonometer
  • the present invention relates to a pressure measurement method, a pressure measurement device, and a tonometer, and is particularly suitable for being applied to an intraocular pressure measurement technique used in an ophthalmic examination.
  • the following two methods are generally known as methods for measuring intraocular pressure. Specifically, a method of applying a certain pressure to the cornea and measuring the intraocular pressure based on the state of depression of the cornea due to this pressure, a contact method of estimating the intraocular pressure by bringing a pressurizer into contact with the cornea, or This is a method for estimating the intraocular pressure by injecting compressed air into the cornea and estimating the relative force of the cornea area deformed by the pressure.
  • Patent Document 3 5,251,627 (Patent Document 3)), and pressurize from above the eyelid with the eyes closed (See JP-A-6-105811 (Patent Document 4), JP-A-8-280630 (Patent Document 5), JP-A 8-322803 (Patent Document 6)), etc.
  • Proposed Invention Disclosure includes JP-A-6-105811 (Patent Document 4), JP-A-8-280630 (Patent Document 5), JP-A 8-322803 (Patent Document 6), etc.
  • the conventional pressure measurement method and the tonometer as the device described above have the following problems. That is, in the method in which the measuring element is brought into direct contact with the cornea, anesthesia is required, and the subject feels discomfort and pain. [0006] Further, in the method described in Patent Documents 13 to 13, since the intraocular pressure is measured in an open eye state, the subject also feels discomfort and pain. In addition, the pressure measurement device itself is large and directly stimulates the cornea, requiring high security, and therefore requires the examiner to be a physician or a health care professional.
  • Patent Documents 416 a method in which an inspection is performed in a state in which the eyelids are closed, that is, in a state in which the eyes are closed. According to the knowledge of the present inventors, in these methods, intraocular pressure is used. The reproducibility of the measurement results was insufficient.
  • an object of the present invention is to provide a pressure measuring method capable of measuring pressure with a simple method and high reproducibility at the time of measurement, and to provide an intraocular pressure measuring device (tonometer) When applied to a subject, intraocular pressure can be measured simply by lightly touching the eyelids, and pressure can be accurately measured by a simple method that does not cause discomfort or pain to the subject.
  • another object of the present invention is to provide a pressure measurement device that allows a subject to measure intraocular pressure.
  • the burden on the cornea in the measurement of intraocular pressure causes discomfort. Therefore, the present inventor studied a method of measuring intraocular pressure without closing the eyelids and placing a burden on the cornea.
  • the present inventor has come up with the idea of using a vibrator.
  • the present inventor conducted various experiments and studies based on the experiments. We have found that there is a characteristic that the current flowing through the vibrator changes according to the substance in contact. Based on this finding, the present inventors conducted further experiments and studies. If the eyeball is vibrated using this vibrator, the current flowing through the vibrator changes according to the intraocular pressure, so it is recalled that the intraocular pressure can be measured by measuring the current value. Reached.
  • the present invention has been devised based on the above study.
  • a pressure measuring device that can directly or indirectly contact the vibration means with the DUT, apply a voltage to the vibration means and vibrate together with the DUT, and change according to the vibration amplitude of the vibration means
  • the current value to be measured is calculated based on the measured current value.
  • the first invention of the present invention is:
  • Vibrating means coupled to the contacting means and vibrating when a voltage is applied thereto is connected to the vibrating means via contacting means having a predetermined shape and contacting an object to be measured to which pressure is applied outward.
  • a voltage is applied to the vibrating means by a voltage applying means for applying an AC voltage to the vibrating means, and a current value flowing to the vibrating means is measured by a measuring means for measuring a value of a current flowing through the vibrating means,
  • the information processing means calculates a resonance point of the device under test based on a change in the current value caused by a change in the vibration frequency.
  • the pressure is measured based on the current value at the point.
  • a reference measurement object serving as a reference for correcting a change in a measured value due to a temperature characteristic of the vibrator is used, and the reference measurement object is used immediately before or after measuring the pressure of the object to be measured. At the same time, the pressure of the reference object is measured, and the pressure of the object is measured by comparing the measured value of the reference object with the measured value of the object.
  • the second invention of the present invention is:
  • Vibrating means coupled to the contact means and capable of vibrating upon application of a voltage
  • Voltage applying means configured to apply an AC voltage to the vibration means
  • Measuring means configured to measure a current value flowing through the vibration means
  • Information processing means configured to be able to calculate a pressure value corresponding to the current value measured by the measuring means
  • a current value flowing through the vibration means can be measured by the measurement means by applying an AC voltage to the vibration means by the voltage application means.
  • the information processing means can calculate the pressure of the measured object.
  • the third invention of the present invention is:
  • Vibrating means coupled to the contact means and capable of vibrating upon application of a voltage
  • Voltage applying means configured to apply an AC voltage to the vibration means
  • Measuring means configured to measure a current value flowing through the vibration means
  • Information processing means configured to be able to calculate a pressure value corresponding to the current value measured by the measuring means
  • a current value flowing through the vibration means can be measured by the measurement means by applying an AC voltage to the vibration means by the voltage application means.
  • the information processing means can calculate the intraocular pressure of the eyeball
  • a resonance point of an object or an eyeball is calculated from a change in a measured current value caused by changing a vibration frequency, and the resonance point is calculated. It is configured to measure the current value near the point.
  • a support means is further provided, and the support means is provided outside the movable area of the contact means and outside the movable area of the vibration means.
  • the reference measurement as a reference for correcting a change in the measurement value due to the temperature characteristic of the vibrator.
  • the pressure of the measured object is measured by executing the measurement of the pressure on the measured object and comparing the measured value of the reference measured object with the measured value of the measured object by the calculating means.
  • the apparatus further includes output means configured to output a measurement result by the measurement means and a calculation result by Z or the calculation means.
  • the contact means is coupled to the vibration means via a fixing member. It is desirable to use an elastic body such as rubber as the fixing member.
  • the technical concept of the present invention is not necessarily limited to the above-described combination.
  • the technical concept of the present invention also includes a technical concept realized by appropriately combining the plurality of inventions described above.
  • a pressure-applied object having a predetermined shape and having a pressure applied to the outside with a simple method and high reproducibility during measurement.
  • the pressure in the measurement object can be measured.
  • the intraocular pressure can be accurately measured by a simple method without affecting the eyeball, it is possible to give an uncomfortable feeling to the subject.
  • the subject can safely and accurately measure the measured intraocular pressure by himself / herself.
  • FIG. 1 is a diagram showing a configuration of a pressure measuring device according to an embodiment of the present invention.
  • FIG. 2 is a schematic diagram showing a measuring device used for measuring intraocular pressure according to an embodiment of the present invention.
  • FIG. 3 is a schematic diagram showing a bimorph vibrator provided in a measuring instrument according to one embodiment of the present invention.
  • FIG. 4 is a circuit diagram showing an equivalent circuit of a resonator according to an embodiment of the present invention and a graph showing frequency-impedance characteristics.
  • FIG. 5 is a graph showing the results of frequency-current characteristics when the internal pressure of a balloon filled with water is changed based on the method for measuring intraocular pressure according to one embodiment of the present invention.
  • FIG. 6 is a graph showing the results of measuring intraocular pressure by directly contacting the measuring instrument according to one embodiment of the present invention with pig eyes.
  • FIG. 7 is a graph showing a result of measuring intraocular pressure by bringing a measuring instrument according to an embodiment of the present invention into contact with a pig eye via an eyelid.
  • FIG. 8 is a graph showing the measurement results of the current / pressure characteristics when the pig eye is directly contacted with the pig eye and the pig eye is brought into contact with the pig eye via the eyelid according to the embodiment of the present invention.
  • FIG. 9 is a graph showing measurement results of frequency-current characteristics when the intraocular pressure of the same subject is measured ten times using the measuring device according to one embodiment of the present invention.
  • FIG. 10 is a schematic diagram illustrating a calibration method for measuring intraocular pressure according to an embodiment of the present invention.
  • FIG. 11 is a graph showing the transition of measurement results when human intraocular pressure is measured using the measuring device according to one embodiment of the present invention and a conventional injection-type tonometer.
  • FIG. 12 is a schematic diagram illustrating a measuring instrument provided with a support according to an embodiment of the present invention.
  • FIG. 13 is a schematic diagram showing a measuring instrument provided with a support base according to an embodiment of the present invention.
  • Figure 1 shows this 1 shows an overall configuration of a pressure measuring device according to one embodiment.
  • a measuring device 1 for actually measuring intraocular pressure As shown in FIG. 1, in a pressure measuring device used as a tonometer according to one embodiment of the present invention, a measuring device 1 for actually measuring intraocular pressure, a piezo driver 2, a terminal block 3, information It has a processing device 4 and a resistor 5.
  • the piezo driver 2 is for amplifying the applied voltage.
  • the terminal block 3 is used to concentrate the input / output wiring, apply the voltage amplified by the piezo driver 2 to the measuring instrument 1 as an output, and measure the potential or voltage as an input. It is.
  • the piezo driver 2 is configured so that the voltage output from the terminal block 3 can be amplified, for example, 15 times.
  • the resistor 5 is for causing a voltage drop between both ends of the resistor 5, and in this embodiment, the resistance value is, for example, lk ⁇ .
  • the information processing device 4 has an information processing unit and an auxiliary storage unit as arithmetic means, such as a personal computer equipped with a node disk, and has a display as output means capable of outputting arithmetic results and measurement results. Having.
  • any device having an information processing unit capable of performing information processing such as force calculation processing using a personal computer and a storage unit using a personal computer can be adopted as the information processing device 4. It is not necessarily limited to a personal computer.
  • An auxiliary storage unit (not shown) provided in the information processing device 4 has an information storage database 4b based on an operating system (OS) 4a for operating the information processing device 4,
  • OS operating system
  • a result processing application 4c, an input data analysis program 4d, an arithmetic processing application 4e, and an output side frequency change program 4f are installed. Then, in the information processing device 4, various analysis processes and arithmetic processes are executed according to these programs. In the examples described later, the measurement processing and the analysis processing are executed based on these programs.
  • FIG. 2 shows the measuring device 1
  • FIG. 3 shows an example of a bimorph type vibrator used in the measuring device 1.
  • the measuring device 1 according to this embodiment has a configuration in which the contactor 14 is brought into contact with the eyelid 16 in measuring the intraocular pressure. That is, in the measuring instrument 1, a vibrator 11 such as a bimorph vibrator as a vibrating means, four rubber stands 12 as elastic bodies, and vibrating while accommodating these vibrators 11 and the rubber stand 12 It has a simple case 13 and a contact 14 that actually contacts the eyelid 16.
  • the vibrator 11 and the eyeball 17 are substantially indirectly in contact with each other and are linked to each other.
  • the vibrator 11 has both ends sandwiched by a pair of rubber stands 12, whereby the vibrator 11 is arranged and fixed at the center of the case 13. As shown in FIG. 3, the vibrator 11 has a configuration in which both sides of a metal plate lib are sandwiched between ceramic elements 11a.
  • the vibrator 11 is electrically connected to a piezo driver 2 (not shown in FIG. 3) via a vibrator cable 15.
  • the vibrator 11 when a voltage is applied to the vibrator 11 with an external force through the vibrator cable 15, the vibrator 11 first vibrates. Then, the vibration is sequentially transmitted to the rubber base 12, the case 13, and the contact 14, so that the entire case 13 vibrates and is transmitted to the eyeball 17 via the contact 14 and the eyelid 16. That is, the measuring device 1 according to the embodiment applies a vibration to the eye to be examined and measures the vibration non-invasively.
  • non-invasive means that a member that directly contacts the cornea (not specifically shown) of the eyeball 17 is not used.
  • the vibrator 11 can be represented by an equivalent circuit shown in FIG. 4A.
  • This equivalent circuit Is an equivalent circuit when the vibrator 11 is in a non-contact state. Even when an arbitrary object comes into contact with the vibrator 11, it can be regarded as basically the same equivalent circuit.
  • Figure 4B shows the frequency 'impedance characteristics of this equivalent circuit.
  • FIG. 4B shows that the vibrator 11 resonates in parallel, and that the impedance changes depending on the applied frequency. Therefore, it can be seen that if the applied AC voltage is always constant, the current flowing through the vibrator 11 changes according to the frequency.
  • one resonance point fs is a mechanical resonance point of the vibrator 11, and the other resonance point fp is a resonance point generated from the vibrator 11.
  • the measuring instrument 1 provided with the vibrator 11 is installed on a vibration-proof rubber (not shown), and other vibrator cables and the like are fixed.
  • the vibrator 11 is irradiated with laser light using a displacement meter, and the vibration amplitude is measured.
  • the applied frequency is from 400Hz to 700Hz at 10Hz intervals.
  • a resonance point is searched for in advance, and set in the vicinity of the resonance point, specifically, in a frequency range before and after the resonance point.
  • the value of the characteristic and the resonance frequency were shifted depending on the hardness of the substance.
  • the vibrator 11 resonates in parallel as described above, and the impedance changes according to the applied frequency. In other words, if the applied AC voltage is always constant, the flowing current changes with the frequency. Therefore, using this characteristic, the current flowing through the vibrator 11 is measured from the voltage drop at the resistor 5 connected in series to the vibrator 11, and the intraocular pressure is calculated based on the measured current value. To do.
  • the measuring device 1 is arranged so as to be in contact with the eyeball 17 via the eyelid 16.
  • an AC voltage is applied to the oscillator 11 based on the frequency change program installed in the information processing device 4.
  • the vibrator 11 is vibrated by the application of the AC voltage, the entire measuring instrument 1 vibrates. This vibration is transmitted to the eyeball 17 via the eyelid 16.
  • the eyeball 17 itself also vibrates according to the intraocular pressure, and the vibration amplitude of the measuring instrument 1 changes.
  • the amplitude of the vibrator 11 also changes, and the current flowing through the vibrator 11 changes with this change.
  • the respective potentials at both ends of the resistor 5 are measured, and the value of the measured potential is input to the information processing device 4.
  • the information processing device 4 arithmetic processing is performed on the value of this potential by an arithmetic processing application, and the difference between them, that is, the voltage, is obtained.
  • a change in current in the vibrator 11 is calculated, and the information processing device 4 calculates an intraocular pressure value based on the current value.
  • the information processing device 4 is provided with a display as an output means. When the change in the current is calculated, the result of the analysis processing according to the analysis program is displayed on the display. I have.
  • FIG. 5B is an enlarged view of the frequency range of FIG. 5A in the vicinity of the resonance point.
  • the measurement device 1 was brought into direct contact with the device, and the measurement was performed in the frequency range of 700 to 850 Hz. Then, the eyelids were closed, and the upper force of the eyelids was also measured. These series of measurements were repeated while changing the pressure in the eyeball.
  • FIG. 6 and FIG. 7 show the results of measuring the frequency / current characteristics in this manner.
  • Fig. 6 shows the measurement results when the measurement device 1 was brought into direct contact with the eyeball
  • Fig. 7 shows the measurement when the upper cap measurement device 1 was brought into contact with the eyelid with the eyelid closed. The result when performing the above is shown.
  • FIGS. 6B and 7B are enlarged views of the frequency range of FIGS. 6A and 7A, respectively, near the resonance point.
  • Fig. 8 shows the pressure dependence of the current value at the frequency of 769Hz (between the maximum point and the minimum point (two resonance points)) in Figs. The result of comparison is shown.
  • the present inventor has found that in the process of proceeding with the measurement using the pig's eye, the temperature characteristic of the vibrator 11 in the measuring instrument 1 causes the current to fluctuate. Therefore, the present inventor has conceived a method of performing measurement after the vibrator 11 continues to vibrate until the temperature is saturated. Thereby, the tonometry can be stably performed.
  • the current characteristics were measured using the measuring device 1 continuously for the same subject. That is, the oscillator 11 is vibrated for 45 minutes, and the oscillator 11 Immediately after summing, the measuring instrument 1 according to this embodiment is brought into contact with the human eyelid, and the current characteristics are measured 10 times at 2 minute intervals.
  • the frequency range where the current characteristics are measured shall be 700-840 Hz.
  • the measuring instrument 1 is separated from the eyelid 16 for each measurement.
  • Figure 9 shows the measurement results.
  • FIG. 9B is an enlarged view of the frequency range of FIG. 9A in the vicinity of the resonance point.
  • the method of vibrating the vibrator 11 until the temperature of the vibrator 11 is saturated which is employed in the measurement of the current characteristics described above, takes time. This is because the vibrator 11 has a temperature characteristic. Then, the present inventor studied a method of minimizing the influence of the temperature characteristic as much as possible, and came to think of a method of performing calibration using a reference table. Fig. 10 shows the calibration procedure using this reference platform.
  • the reference table 21 is provided on an elastic spring 22 made of, for example, rubber and having the same properties as when an eyeball is pressed.
  • the contact 14 of the measuring device 1 is brought into contact with the reference table 21 and the measurement is performed.
  • the contact 14 of the measuring device 1 is brought into contact with the eyelid 16 to measure the intraocular pressure.
  • the value measured on the eyelid is calibrated based on the value measured by the reference table 21 to improve the measurement accuracy.
  • the amplification factor of the value y obtained on the eyelid (X is expressed by the following (1) ) Calculate from the formula.
  • the amplification factor ⁇ in the equation (1) is a ratio between the reference base 21 where the pressure is always constant and the pressure on the eyelid 16 to be measured. Since the pressure of the reference base 21 is constant, the measured value is always Since it becomes constant, the intraocular pressure value measured on the eyelid 16 can be accurately obtained using the amplification factor ⁇ . Further, since the measurement for the reference base 21 and the measurement for the eyelids 16 are performed almost simultaneously, the influence of the temperature characteristics can be minimized.
  • the present inventor measures the intraocular pressure by bringing the measuring instrument 1 according to the embodiment into contact with the human eyelid, and measures the conventional intraocular pressure as a comparative example.
  • the intraocular pressure in the human eyeball was measured using a projection tonometer.
  • Figure 11 shows the results. In FIG. 11, the number of times of measurement using the measuring device 1 and the number of times of measurement using the conventional ejection tonometer are shifted by one time. This is in order to cope with the change due to the continuous measurement of the intraocular pressure determined in Example 3.
  • the present inventor has found that in order to use the measuring instrument 1 according to this embodiment as a tonometer with improved reproducibility, every time it is brought into contact with a human eyelid, We found that it was necessary to make contact under the same conditions. However, it is difficult to place the case 13 of the measuring device 1 on the human eyelid when measuring by bringing the contact 14 of the measuring device 1 into contact with the human eyelid. Therefore, the present inventor studied and conceived of providing a support for supporting the case 13 of the measuring instrument 1. The configuration of the measuring instrument 1 provided with this support is shown in FIGS.
  • the support 23 supports the case 13 and is provided with a concave curved portion having a shape close to a skeleton around a human eye.
  • the side shown in FIG. 12 is formed so as to be on the left or right side of the human face.
  • the left side is the nose side with respect to the eyes and the right side is the right side. It is configured to be on the temple side with respect to the eyes.
  • the support base 23 is configured to support the measuring instrument 1 and cover the periphery of the eyes of the human face.
  • the contactor 14 comes into contact with the eyelid 16 by contacting the periphery of the human eyeball with the concave curved portion of the support 23. Also, make sure that this support 23 does not affect the measurement of intraocular pressure.
  • the support base 23 is fixed outside the case 13 and attached to a portion that does not hinder vibration outside the movable area (vibration area) of the contact 11.
  • the user's power of the measuring device 1 is used to measure the intraocular pressure while gripping the support base 23 and use it for the case 13 in which the contactor 14 and the vibrator 11 are housed during vibration. Is not touched. Therefore, the position of the contact 14 is fixed relative to the support base 23 without affecting the measurement in the measuring device 1, and the contact 14 always contacts the human eyelid under the same conditions. It is possible to do.
  • a bimorph type vibrator is employed as the vibrator used in the measuring device 1, but the vibrator uses a current value according to the amplitude of vibration. It is possible to employ any vibrator having a change in frequency. For example, it is possible to use a piezoelectric ceramic vibrator such as a Langevin type vibrator.
  • an elastic rubber which is an elastic body, is used as a fixing member for fixing the vibrator 11 to the case 13.
  • an elastic spring, a synthetic resin, or the like is used. It is possible to use other materials that can fix the vibrator with an appropriate force.
  • the vibrator 11 may further include, for example, brass or Alternatively, a weight having a metallic force such as stainless steel (stainless steel), lead (Pb), or copper (Cu) may be provided.
  • the weight can be provided at an arbitrary portion of the vibrator 11, but is preferably provided at the center of a plane perpendicular to the amplitude direction of the vibrator 11 in consideration of the stability of vibration.

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Abstract

Il est prévu un procédé de mesure de la pression dans lequel une pression est mesurée par un procédé simple à haute reproductibilité et un dispositif de mesure de la pression intraoculaire capable de mesurer une pression intraoculaire par simple contact avec une paupière et avec lequel un sujet peut lui-même effectuer la mesure de la pression intraoculaire. Le dispositif de mesure de la pression intraoculaire est constitué d’une unité de mesure (1), d’un circuit d’attaque piézoélectrique, d’un support terminal, d’un dispositif de traitement d’informations et d’une résistance. L’unité de mesure (1) est constituée d’un vibreur (11) tel qu’un vibreur bimorphe, de quatre supports en caoutchouc (12), d’un boîtier (13) susceptible de vibrer avec le vibreur (11) et les supports en caoutchouc (12) reçus dans le boîtier, et d’un contacteur (14) venant au contact d’une paupière (16). Lors de la mesure de la pression intraoculaire, le contacteur (14) est amené au contact de la paupière (16). Le vibreur (11) est constitué d’un vibreur bimorphe dans lequel un courant électrique varie en fonction de la pression interne d’un objet à mesurer au contact du vibreur avec une tension alternative constante appliquée au vibreur. Une pression telle qu’une pression intraoculaire de l’objet à mesurer est mesurée par mesure d’une valeur de courant électrique circulant dans le vibreur.
PCT/JP2005/004916 2004-04-23 2005-03-18 Procede de mesure de la pression, dispositif de mesure de la pression et tonometre WO2005102150A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05721103A EP1738681A4 (fr) 2004-04-23 2005-03-18 Procede de mesure de la pression, dispositif de mesure de la pression et tonometre
US11/578,910 US7713197B2 (en) 2004-04-23 2005-03-18 Pressure measuring method, pressure measuring device, and tonometer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004-128423 2004-04-23
JP2004128423A JP4583801B2 (ja) 2004-04-23 2004-04-23 圧力測定方法および圧力測定装置ならびに眼圧計

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US (1) US7713197B2 (fr)
EP (1) EP1738681A4 (fr)
JP (1) JP4583801B2 (fr)
KR (1) KR20070004981A (fr)
CN (1) CN100571610C (fr)
RU (1) RU2372021C2 (fr)
WO (1) WO2005102150A1 (fr)

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DE102006033035B4 (de) * 2006-07-14 2015-06-03 Universität Bremen Vorrichtung und Verfahren zur berührungslosen Innendruckbestimmung
KR100936047B1 (ko) 2008-03-03 2010-01-08 한국표준과학연구원 안압계 테스팅 장치
EP2477535A1 (fr) * 2009-09-18 2012-07-25 Orthomems, Inc. Dispositifs de capteur à systèmes micro-électro-mécaniques ophtalmiques pouvant être implantés et procédés pour la chirurgie de l' il
JP2013505076A (ja) 2009-09-18 2013-02-14 オーソメムス， インコーポレイテッド 緑内障監視のための埋込式ｍｅｍｓ眼圧センサデバイスおよび方法
KR101114819B1 (ko) * 2010-07-23 2012-02-15 (재)예수병원유지재단 접촉식 안압측정장치
PL2458357T5 (pl) * 2010-11-29 2018-03-30 Air Products And Chemicals, Inc. Sposób i urządzenie do mierzenia ciśnienia gazu
KR101233966B1 (ko) * 2011-01-19 2013-02-18 주식회사 휴비츠 안압 측정 방법
KR101329334B1 (ko) * 2012-09-24 2013-11-13 충남대학교산학협력단 비침습적 압력측정장치
CN103940547A (zh) * 2013-07-17 2014-07-23 贵州兴化化工股份有限公司 一种脱碳塔压力测试方法
JP2015047354A (ja) * 2013-09-02 2015-03-16 セイコーエプソン株式会社 超音波測定装置及び超音波測定方法
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WO2018031386A1 (fr) * 2016-08-09 2018-02-15 Li Zan Dispositifs portables de surveillance de maladies oculaires et procédés associés
CN106725298B (zh) * 2017-03-05 2019-04-30 苏州云目医疗技术有限公司 一种运动机构、眼压计测压探头以及眼压计
JP7110681B2 (ja) * 2018-03-30 2022-08-02 株式会社ニデック 非接触式超音波眼圧計
US20210068656A1 (en) * 2018-03-30 2021-03-11 Nidek Co., Ltd. Non-contact ultrasonic ophthalmotonometer
JP7110680B2 (ja) * 2018-03-30 2022-08-02 株式会社ニデック 非接触式超音波眼圧計
CN109793496A (zh) * 2018-12-04 2019-05-24 苏州大学 一种结合传感器和ss-oct技术测试眼压的装置及应用
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JP7259599B2 (ja) * 2019-07-03 2023-04-18 株式会社ニデック 超音波眼圧計
KR102531033B1 (ko) * 2020-08-07 2023-05-11 한양대학교 산학협력단 안압 측정 장치 및 방법
WO2022031096A1 (fr) * 2020-08-07 2022-02-10 한양대학교 산학협력단 Dispositif et procédé de mesure de la pression intraoculaire
CN113884231B (zh) * 2021-09-29 2023-05-30 中国科学院光电技术研究所 一种测试压电陶瓷驱动器输出力的装置
CN113866544B (zh) * 2021-09-29 2023-05-30 中国科学院光电技术研究所 一种测量压电陶瓷驱动器负载下位移输出的装置
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Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US319276A (en) 1885-06-02 Waist-belt clasp
JPS57206424A (en) * 1981-03-31 1982-12-17 Fraunhofer Ges Forschung Apparatus for measuring eye pressure
JPH01162166A (ja) * 1987-12-18 1989-06-26 Yokogawa Hewlett Packard Ltd Ｑ測定器
JPH02180241A (ja) 1988-09-28 1990-07-13 Univ Ohio 非接触超音波眼圧計
US5251627A (en) 1991-06-27 1993-10-12 Morris Donald E Non-invasive measurement of eyeball pressure using vibration
JPH06105811A (ja) 1992-09-29 1994-04-19 Kowa Co 眼圧計
US5375595A (en) 1993-03-17 1994-12-27 The Regents Of The University Of Calif. Apparatus and method for non-contact, acoustic resonance determination of intraocular pressure
JPH08280630A (ja) 1995-04-10 1996-10-29 Kowa Co 閉眼式眼圧測定方法および装置
JPH08322803A (ja) 1995-05-31 1996-12-10 Canon Inc 眼圧計
EP0764842A2 (fr) 1995-09-20 1997-03-26 Axiom Co., Ltd. Circuit de détection d'un déviation en fréquence et appareil de mesure utilisant ce circuit
WO2001015594A1 (fr) 1999-08-31 2001-03-08 Bioresonator Ab Procede et dispositif de determination de la pression intra-oculaire en mesurant le changement des courbes de resonance
WO2002078531A1 (fr) * 2001-03-30 2002-10-10 Waseda University Procede et dispositif de mesure de la tension intraoculaire
WO2002100260A1 (fr) 2001-06-13 2002-12-19 Sis Ag Surgical Instrument Systems Dispositifs et procedes de determination de la pression interne d'un oeil
JP2004267299A (ja) * 2003-03-05 2004-09-30 Univ Nihon 眼圧検査装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192765A (en) 1962-07-17 1965-07-06 Franklin Institute Vibration tonometer
EP0157533B1 (fr) * 1984-03-26 1991-06-05 Seiko Instruments Inc. Appareil pour mesurer la pression, p.ex. un baromètre
US4646754A (en) * 1985-02-19 1987-03-03 Seale Joseph B Non-invasive determination of mechanical characteristics in the body
US5830139A (en) 1996-09-04 1998-11-03 Abreu; Marcio M. Tonometer system for measuring intraocular pressure by applanation and/or indentation

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US319276A (en) 1885-06-02 Waist-belt clasp
JPS57206424A (en) * 1981-03-31 1982-12-17 Fraunhofer Ges Forschung Apparatus for measuring eye pressure
JPH01162166A (ja) * 1987-12-18 1989-06-26 Yokogawa Hewlett Packard Ltd Ｑ測定器
JPH02180241A (ja) 1988-09-28 1990-07-13 Univ Ohio 非接触超音波眼圧計
US5251627A (en) 1991-06-27 1993-10-12 Morris Donald E Non-invasive measurement of eyeball pressure using vibration
JPH06105811A (ja) 1992-09-29 1994-04-19 Kowa Co 眼圧計
US5375595A (en) 1993-03-17 1994-12-27 The Regents Of The University Of Calif. Apparatus and method for non-contact, acoustic resonance determination of intraocular pressure
JPH08280630A (ja) 1995-04-10 1996-10-29 Kowa Co 閉眼式眼圧測定方法および装置
JPH08322803A (ja) 1995-05-31 1996-12-10 Canon Inc 眼圧計
EP0764842A2 (fr) 1995-09-20 1997-03-26 Axiom Co., Ltd. Circuit de détection d'un déviation en fréquence et appareil de mesure utilisant ce circuit
WO2001015594A1 (fr) 1999-08-31 2001-03-08 Bioresonator Ab Procede et dispositif de determination de la pression intra-oculaire en mesurant le changement des courbes de resonance
WO2002078531A1 (fr) * 2001-03-30 2002-10-10 Waseda University Procede et dispositif de mesure de la tension intraoculaire
EP1374759A1 (fr) 2001-03-30 2004-01-02 Waseda University Procede et dispositif de mesure de la tension intraoculaire
WO2002100260A1 (fr) 2001-06-13 2002-12-19 Sis Ag Surgical Instrument Systems Dispositifs et procedes de determination de la pression interne d'un oeil
JP2004267299A (ja) * 2003-03-05 2004-09-30 Univ Nihon 眼圧検査装置

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP1738681A4 *
UJIIE H. ET AL: "Kikai Shindoshi o Mochiita Hyomen Karano Kin Kinchodo ni Kansaru Parameter Keisoku no Kiso Jikken.", THE INSTITUTE OF ELECTRONICS, INFORMATION AND COMMUNICATION ENGINEERS., vol. 92, no. 310, 19 November 1992 (1992-11-19), pages 47 - 52, XP002993464 *

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US7713197B2 (en) 2010-05-11
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EP1738681A4 (fr) 2009-07-29
RU2372021C2 (ru) 2009-11-10
CN101026990A (zh) 2007-08-29
KR20070004981A (ko) 2007-01-09
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CN100571610C (zh) 2009-12-23
JP4583801B2 (ja) 2010-11-17

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