Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
  • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
  • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
  • A01N47/44—Guanidine; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
  • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
  • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
  • A61L12/141—Biguanides, e.g. chlorhexidine
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B08—CLEANING
  • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
  • B08B1/00—Cleaning by methods involving the use of tools
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B08—CLEANING
  • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
  • B08B1/00—Cleaning by methods involving the use of tools
  • B08B1/10—Cleaning by methods involving the use of tools characterised by the type of cleaning tool
  • B08B1/14—Wipes; Absorbent members, e.g. swabs or sponges
  • B08B1/143—Wipes
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/0005—Other compounding ingredients characterised by their effect
  • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/26—Organic compounds containing nitrogen
  • C11D3/32—Amides; Substituted amides
  • C11D3/323—Amides; Substituted amides urea or derivatives thereof
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/37—Polymers
  • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • C11D3/3726—Polyurethanes
• • G—PHYSICS
  • G02—OPTICS
  • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
  • G02C13/00—Assembling; Repairing; Cleaning
  • G02C13/008—Devices specially adapted for cleaning contact lenses

Definitions

• the present invention relates to a contact lens cleaning sheet.
• a contact lens a water-containing soft contact lens excellent in a feeling of wearing, a hard contact lens having a high oxygen permeability, and the like are generally and widely used. All of these contact lenses require care such as cleaning after being worn, and in particular, hydrous soft contact lenses require disinfection treatment to prevent contamination by microorganisms such as bacteria and fungi.
• a method of cleaning contact lenses a method of rubbing with fingers using a cleaning solution containing a surfactant or an abrasive, or a multipurpose cleaning, disinfecting, or preserving solution, which has recently become popular for soft contact lenses.
• a method of immersing in a cleaning solution containing hydrogen peroxide or a protease to perform cleaning is known.
• a contact lens cleaning sheet in which a nonwoven fabric web or a water-absorbing material is impregnated with a cleaning solution containing a surfactant or a preservative for example, Patent Documents 1, 2, and 3 See.
• these techniques involve the use of components that cause irritation to the eyes, such as preservatives, especially preservatives, such as benzalkonium chloride, benzethonium chloride, chlorhexidine salt, sorbic acid and its sodium.
• preservatives especially preservatives, such as benzalkonium chloride, benzethonium chloride, chlorhexidine salt, sorbic acid and its sodium.
• a salt or the like adheres to or adheres to the contact lens.
• a nonwoven fabric or a woven fabric made of a fiber having an affinity for a protein is added to a surfactant.
• a cleaning sheet impregnated with a cleaning liquid for example, see Patent Documents 4, 5, 6, 7, and 8) is disclosed.
• a contact lens cleaner characterized by impregnating a water-absorbent sheet material with at least one of sodium chloride and potassium salt, and a preservative or a cleaning solution containing a preservative and ethanol water (for example, see Patent References 9 and 10) are disclosed.
• these preservatives are generally sterilized, such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, sorbic acid, potassium sorbate, and sodium sorbate, which are generally known as preservative components.
• Known ingredients include clohexhexinate, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, and cetyltrimethylammonium bromide. These preservatives transfer the preservatives to the contact lenses used to ensure the bacteriostatic and sterility of the water-absorbent sheet material used in the cleaner, causing eye irritation. Was awake.
• Patent Document 1 Japanese Patent Publication No. 1-46047
• Patent Document 2 JP-A-6-317769
• Patent Document 3 Japanese Patent Publication No. 7-74865
• Patent Document 4 JP-A-2000-19464
• Patent Document 5 Japanese Patent Application Laid-Open No. 2000-19465
• Patent Document 6 JP-A-2000-19466
• Patent Document 7 JP-A-2000-19467
• Patent Document 8 JP-A-2000-19468
• Patent Document 9 Japanese Patent Application Laid-Open No. 2002-296550
• Patent Document 10 Japanese Patent Application Laid-Open No. 2002-296551 Disclosure of the invention
• An object of the present invention is to effectively remove stains such as proteins adhered or deposited on a contact lens by a simple washing operation.
• An object of the present invention is to provide a contact lens cleaning sheet substantially free of irritation.
• the present inventors can ensure the sterility of a nonwoven fabric or a woven or knitted fabric used for a contact lens cleaning sheet, and do not transfer to a contact lens when cleaning the contact lens with the cleaning sheet.
• the hexamethylene biguanide derivative represented by the general formula (I) described later has a property that it is unexpectedly easily adsorbed to nonwoven fabric or woven or knitted material.
• a cleaning sheet is prepared by combining a cleaning solution containing the derivative with a nonwoven fabric or a woven or knitted fabric, the sterility of the nonwoven fabric or the woven or knitted fabric can be ensured.
• the present inventors have found that the derivative is hardly transferred to a contact lens, and have completed the present invention.
• the present invention provides:
• X and Y may be the same or different, and each represents a group represented by the formula: one C ⁇ T ⁇ , or a formula:
• a contact lens cleaning kit comprising the cleaning liquid according to the above [1] and a nonwoven fabric or a knitted fabric.
• dirt such as proteins deposited or adhered on the surface of the contact lens can be effectively removed only by gently rubbing the contact lens, and the contact lens after cleaning can be used as it is.
• a contact lens cleaning sheet that does not substantially irritate the eyes when worn is obtained.
• the contact lens cleaning sheet of the present invention (hereinafter sometimes referred to as a cleaning sheet) is obtained by impregnating a non-woven fabric or a woven or knitted fabric with a cleaning liquid, and the cleaning liquid is a hexane represented by the general formula (I).
• a cleaning sheet is obtained by impregnating a non-woven fabric or a woven or knitted fabric with a cleaning liquid, and the cleaning liquid is a hexane represented by the general formula (I).
• invitation of methylene biguanide One of the major features is that it contains conductors.
• the washing liquid of the present invention can be prepared by mixing and dissolving various components described below in water as a solvent by a conventional method.
• water any water such as tap water, distilled water, purified water and the like, which is not particularly limited, can be used.
• water as a solvent may contain a solvent component other than water as long as it does not substantially cause eye irritation.
• the solvent constitutes the remainder of the cleaning liquid excluding various components.
• the hexamethylene biguanide derivative represented by the general formula (I) is used as a preservative or a bactericide in the present invention.
• the hexamethylene biguanide derivative includes hexamethylene biguanide and a polymer of hexamethylene biguanide (ie, polyhexamethylene biguanide).
• the polymer refers to a polymer having a degree of polymerization of a hexamethylene biguanide derivative wherein n in the general formula (I) is 2 or more.
• N is preferably in the range of 2-500, more preferably in the range of 2-300, and even more preferably in the range of 4-200.
• n is preferably 2 or more because there is substantially no incorporation of the derivative into the polymer chain of the resin constituting the contact lens, while n is preferably 500 or less from the viewpoint of obtaining good sterilization performance. Preferably it is. Therefore, the present invention
• the hexamethylene biguanide derivative is polyhexamethylene biguanide.
• the derivative may be a salt such as a hydrochloride, a borate, an acetate, a dalconate, a sulfonate, a tartrate, and a citrate.
• Hexamethylene biguanide derivatives used in the present invention are commercially available and can be used.
• Commercially available products include, for example, “AriagardE”, “CosmocilCQ”, “ProxelIB”, “VantocilIB” (trade name, manufactured by Abishia K.K., trade name), “Mikrokill”, “Mikrok ill20” [trade name, Brooks ), Product name).
• the n of the hexamethylene biguanide derivative in these commercial products is about 12.
• the hexamethylene biguanide derivative may be used singly or as a mixture of two or more.
• the content of the hexamethylene biguanide derivative in the washing solution of the present invention is good. From the viewpoint of exhibiting a strong bactericidal action and sufficiently suppressing eye irritation, it is preferably in the range of 0.1 to 1 ppm, more preferably in the range of 0.5 to 5 ppm. In addition, “ppm” represents the concentration of the derivative expressed in parts by weight of the derivative in 1 million parts by weight of the washing liquid.
• the hexamethylene biguanide derivative of the present invention exhibits an adsorptive effect on the nonwoven fabric or woven or knitted fabric used in the present invention, and further exerts a sterilizing effect on the nonwoven fabric or woven or knitted fabric.
• the adsorbed derivative is hard to be desorbed from the nonwoven fabric or the woven or knitted fabric used in the present invention, the derivative is hardly eluted from the nonwoven fabric or the woven or knitted fabric constituting the cleaning sheet of the present invention. Wearing contact lenses immediately without rinsing with water after rinsing causes virtually no eye irritation. Also, the derivative does not substantially accumulate in the contact lens.
• a polymer compound having a property of increasing the viscosity is added from the viewpoint of reducing the friction between the contact lens and the cleaning sheet and preventing the lens from being damaged more sufficiently.
• the high molecular compound include vinyl polymers such as polyvinylpyrrolidone polymers, polyvinyl alcohol polymers, and the like, cenorelose derivatives such as hydroxypropylmethylcellulose, hydroxyethynoresenorelose, and methinoresenorelose, and gelatin. Of water-soluble polymers. These polymer compounds can be used alone or in combination of two or more.
• the content of the polymer compound in the washing solution of the present invention is preferably 0.01 to 1% by weight, more preferably 0.05 to 0.3% by weight.
• the pH of human tears is about 7, and the osmotic pressure is about 290 mOsm.
• the washing solution is preferably adjusted to a pH and / or osmotic pressure close to the tear.
• the pH of the cleaning solution of the present invention is preferably in the range of 68, and more preferably in the range of 6.5 to 7.5 from the viewpoint of ensuring sufficient safety for the eyes. It is preferable to use at least one buffer for adjusting the pH of the washing solution.
• the powerful buffer may be appropriately selected from known ones that are not particularly limited. Examples of the buffer include boric acid buffer, citrate buffer, glycine buffer, Tris buffer [tris (hydroxymethyl) aminomethane buffer], phosphate buffer, carbonate buffer and the like. Eye among these Phosphate buffer is preferred because of its low irritation and low impact on contact lenses.
• phosphate buffer sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate S are generally widely used and easily available. It is preferably used. These buffers can be used alone or in combination of two or more. The content of the buffer in the washing solution may be appropriately selected so as to obtain a desired effect.
• the osmotic pressure of the cleaning solution of the present invention is preferably in the range of 200 to 400 mOsm, and more preferably in the range of 250 to 350 mOsm, from the same viewpoint as pH. It is preferable to use an isotonic agent for adjusting the osmotic pressure of the washing solution.
• the tonicity and strength of the tonicity agent are not particularly limited as long as it is an ophthalmically acceptable compound; inorganic salts such as sodium chloride, potassium chloride and sodium bicarbonate; glycols such as glycerin, propylene glycol and ethylene glycol; These glycols include nonionic organic compounds such as polymers having an average molecular weight of 1000 or less; and combinations thereof.
• the content of the tonicity agent in the washing solution may be appropriately selected so as to obtain a desired effect.
• a sequestering agent is added to the cleaning solution of the present invention in order to remove polyvalent metal ions deposited on the surface of the worn contact lens before cleaning with the cleaning sheet of the present invention.
• the sequestering agent is not particularly limited as long as it is an ophthalmically acceptable compound.
• polyvalent carboxylic acids such as ethylenediaminetetraacetic acid, dalconic acid, citric acid and tartaric acid, and their sodium salts and potassium Salts such as salts can be mentioned.
• These sequestering agents can be used alone or in combination of two or more.
• the content of the sequestering agent in the cleaning solution may be appropriately selected so as to obtain a desired effect.
• a surfactant is appropriately added to the cleaning solution of the present invention as long as compatibility with the contact lens is allowed. That can be S.
• the “range in which the compatibility with the contact lens is acceptable” refers to a range in which the eye irritation substantially does not substantially adhere to the lens or the lens shape does not substantially change.
• the surfactant that can be added include any nonionic surfactant. Among them, block copolymers of polyethylene oxide and polypropylene oxide are preferred. Used appropriately.
• the nonionic surfactants can be used alone or in combination of two or more.
• the content of the nonionic surfactant in the washing solution may be appropriately selected so as to obtain a desired effect.
• the cationic surfactant and the anionic surfactant may be contained as long as the desired effects of the present invention are not impaired.
• the cleaning liquid of the present invention may be supplemented with an enzyme or a protein softener. Dirt such as proteins deposited on the surface of the contact lens can be decomposed by the enzyme or protein softener contained in the cleaning solution, and the cleanliness of the contact lens is improved.
• the powerful enzyme and protein softener are not particularly limited as long as they are ophthalmically acceptable compounds. Examples thereof include proteases, lipases, urea, and glycine known in the ophthalmic field. Enzymes and protein softeners can be used alone or in combination of two or more. Their contents in the cleaning solution may be appropriately selected so as to obtain a desired effect S.
• the nonwoven fabric or woven or knitted fabric used in the present invention will be described. Since the nonwoven fabric or the woven or knitted fabric functions as a support for the cleaning liquid of the present invention, in the following, both may be referred to as a support.
• the nonwoven fabric or woven or knitted fabric of the present invention is generally composed of a main fiber or a mixture of a main fiber and a binder fiber.
• the main fiber refers to a fiber other than the binder fiber in the fibers constituting the nonwoven fabric or the woven or knitted fabric of the present invention.
• the term “fiber” usually refers to a main fiber, except for a particular description as a binder fiber.
• the shape of the support of the cleaning sheet of the present invention is not particularly limited, but in consideration of the convenience of use, a thin sheet, for example, preferably having a thickness of 0.001. 3 mm, more preferably 0.01 lmm, vertical length is preferably 10 200 mm, more preferably 30 100 mm, horizontal width is preferably 10 200 mm, more preferably 30 100 mm Les, which is preferred. Further, the basis weight of the support is usually preferably about 10 to 100 g / m 2 . [0031] As the support, any known nonwoven fabric or woven or knitted fabric can be used, and the production method thereof is not particularly limited. From the viewpoint of producing the support in large quantities and at low cost, the support is preferably a nonwoven fabric.
• a nonwoven fabric can be obtained by mechanically knitting or mixing a main fiber alone or a mixture of a main fiber and a binder fiber, or by laminating and adhering or entangled the fibers.
• a dry method [short fibers (25 lOOmZm) is used for a machine called a card.
• Spunbonding method or meltblowing method The melted raw material resin is eluted from the tip of the sponge and spun to form a laminate of continuous long fibers on the net.) Method).
• a chemical bond method an adhesive resin of emulsion type is applied to the webs by impregnation or spraying, etc., and the intersection of the fibers is heated by heating.
• Bonding method thermal bonding method (a method of heat fusion, a method of bonding fibers by thermocompression bonding or heat treatment of a web in which heat-fused fibers are mixed.
• a single method such as a calendar method and an embossed calendar method
• a needle punch method a method in which the web is repeatedly pierced with a needle (needle) that moves up and down due to infarction, and the fibers are entangled and bonded.
• water entanglement method a method of tying fibers together by jetting a high-pressure water stream into a web in a columnar manner
• the material of the fibers constituting the support is not particularly limited.
• Examples of the material of the support of the present invention include cotton, rayon, polyolefin (polyethylene, propylene, polymethylpentene), polybutyl alcohol-based polymers (polybutyl alcohol, ethylene-modified polybutyl alcohol, etc.), polyamide ( PA6, PA66, PA6_12, various types of nylon, etc., polyester (polyethylene terephthalate, polybutylene terephthalate, polylactic acid, etc.), polyacrylonitrile, polyurethane That can be S.
• the support of the present invention can be prepared by mixing fibers made of these materials singly or in an arbitrary ratio. These materials may have been arbitrarily modified.
• the material of the support preferably contains at least one selected from the group consisting of polyolefin, polyamide and polyester. Therefore, it is more preferable to impregnate a cleaning liquid containing a hexamethylene biguanide derivative into a nonwoven fabric or a woven or knitted fabric made of fibers of such a preferable material to produce the cleaning sheet of the present invention.
• the nonwoven fabric or woven or knitted fabric constituting the cleaning sheet can be kept sanitary, and the amount of the hexamethylene biguanide derivative eluted from the nonwoven fabric or woven or knitted fabric can be significantly reduced, and eye irritation can be more effectively achieved. Can be suppressed.
• the total content of polyolefin, polyamide and polyester contained in the material of the support is preferably 10 to 100% by weight, more preferably 30 to 100% by weight.
• the nonwoven fabric or woven or knitted fabric may be impregnated with a cleaning liquid and then sterilized.
• the sterilization method is not limited, autoclave sterilization is generally used from the viewpoint of simplicity and the like.
• the material of the nonwoven fabric or the woven or knitted fabric at that time preferably contains polyamide and / or polyester from the viewpoint of exhibiting good sterilization resistance.
• the total content of polyamide and polyester is preferably 20-100% by weight, more preferably 50-100% by weight.
• the material of the support contains polyamide and polyester.
• the total content of the polyamide and polyester preferably 20-100 weight 0/0, more preferably 50 to 100 wt%.
• the weight ratio of polyester to polyamide (polyester: polyamide) contained in the nonwoven fabric or woven or knitted fabric is preferably 4: 1 to 1: 4, and more preferably 2: 11: 2.
• polyethylene terephthalate and polybutylene terephthalate are used as polyester, and polyamide is used as polyamide.
• PA6, PA66 and the like are preferred.
• the average fiber diameter in the fibers constituting the support is preferably 0. 3- 10 ⁇ m, more preferred properly by the use of ultra-fine fibers of 0. 3- 7 ⁇ ⁇ , to the support
• the impregnation amount of the cleaning liquid can be increased, and the support can be provided with higher flexibility.
• a method of producing ultrafine fibers a method of removing the sea component of the sea-island structure fiber or a method of splitting the splittable fiber by a water flow or the like is known, but the latter method is generally used. Used for The average fiber diameter is determined by converting the diameter of a circle having the same area as the fiber cross-sectional area.
• the content of the ultrafine fibers in the support is preferably 50 to 100% by weight, more preferably 70 to 100% by weight.
• the fibers constituting the support include non-round cross-section fibers. More preferably, it contains fibers.
• the term "non-circular cross section" is not strict. For example, when a fiber cross section is observed by an electron microscope (magnification: about 3000 times), it has at least three corners that are not round at first glance. More specifically, it refers to a shape that can be determined to be a polygon such as a triangle or a quadrangle, or a flat shape such as an ellipse.
• the content of the fiber having a non-round cross section in the support is preferably 50 to 100% by weight, more preferably 70 to 100% by weight.
• the cleaning sheet of the present invention it is preferable to prevent fibers (lint) detached from the cleaning sheet from adhering to the contact lens when the dirt of the contact lens is wiped off.
• fibers (lint) detached from the cleaning sheet it is preferable to use a woven or knitted fabric made of long fibers or a spunbond nonwoven fabric as the support.
• a nonwoven fabric made of short fibers by using an entanglement treatment such as a water entanglement or a binder fiber, it is possible to suppress the generation of lint during wiping.
• binder fiber those having a core-sheath structure (core: fiber-forming resin, sheath: binder resin) are preferred.
• core fiber-forming resin
• sheath binder resin
• a resin having a lower melting point than the core component is preferable. Fats or those having a low glass transition temperature and having thermal adhesiveness are preferred.
• Binder One fiber is not particularly limited, but the core component is polyethylene terephthalate and the sheath component is modified polyethylene terephthalate, or the core component is polypropylene and the sheath component is Is generally used.
• Specific examples of the binder fiber include “Sofit N720” (trade name) made by Kuraray clay.
• the binder fiber may be arbitrarily mixed with the support and used.
• the content of the binder fiber is as follows.
• the support it is preferably 530% by weight, more preferably 525% by weight. Therefore, in this case, the content of the main fiber in the support is preferably 70 to 95% by weight, more preferably 75 to 95% by weight.
• a treatment such as autoclave sterilization may be appropriately performed.
• the main fibers are made of ultrafine fibers having an average fiber diameter of 0.310 xm, particularly a non-round cross section, containing polyester and polyamide in the material thereof. Those containing binder fibers having a core-sheath structure are particularly preferred.
• the water absorbency of the cleaning sheet of the present invention is not particularly limited, but is preferably from the viewpoint of improving the flexibility of the cleaning sheet obtained by impregnating the support with the cleaning liquid. It is about 100-5000%, more preferably about 700-1400%. Note that the water absorbency of the washing sheet specifically means the water absorbency of the support. The water absorption is determined by the method described in the examples described below.
• the cleaning sheet of the present invention can be obtained by impregnating a nonwoven fabric or a woven or knitted fabric having a desired shape with a cleaning liquid containing the hexamethylenebiguanide derivative by a known method. As a form of impregnation, it is preferable that the cleaning liquid is uniformly impregnated into the entire nonwoven fabric or woven or knitted fabric.
• the content of the cleaning liquid in the cleaning sheet can be appropriately set in consideration of the water absorption of the nonwoven fabric or woven or knitted fabric used.
• the cleaning sheet of the present invention obtained as described above is used by directly applying to a contact lens and rubbing lightly. As a result, it is possible to effectively remove stains such as proteins adhered or deposited on the contact lens, and it is possible to wear it on the eyes as it is after washing.
• the contact lens can be stored with the contact lens sandwiched between the cleaning sheets of the present invention, or can be disinfected or stored using a commercially available lens case and a cleaning solution.
• the cleaning sheet of the present invention can be subjected to a sterilization operation, packaging, or the like, if desired.
• the cleaning sheet of the present invention is housed in a packaging material and sealed, and can be opened and taken out at the time of use, drying of the impregnated cleaning liquid from the cleaning sheet is prevented. It is easy to use, portable and convenient.
• the form of the packaging material is not particularly limited, but a bag-like material is preferred in terms of portability.
• the material of the packaging material is preferably a film having low water vapor permeability from the viewpoint of preventing drying of the cleaning sheet and the ease of opening.
• the total amount of the cleaning liquid in the packaging material may exceed the water absorption of the above-mentioned cleaning sheet.
• the packaging material contains the cleaning sheet (support and cleaning liquid) of the present invention and excess cleaning liquid. Therefore, in the above-mentioned cleaning tool, the total amount of the cleaning liquid present in the packaging material is a force that can be arbitrarily selected from a wide range. Normally, 100 to 100 parts by weight of the cleaning sheet support (nonwoven fabric or woven or knitted fabric) is used.
• the method of manufacturing a powerful cleaning tool is not particularly limited. 2. A method in which a nonwoven fabric or a woven or knitted fabric having a desired shape is filled in a packaging material in advance, and a washing liquid containing a hexamethylene biguanide derivative is added to the packaging material.
• a contact lens cleaning kit including the cleaning liquid and a nonwoven fabric or a woven or knitted fabric (preferably a sheet).
• the power kit is used by impregnating a non-woven fabric or a woven or knitted fabric with a cleaning solution in an appropriate amount to obtain the cleaning sheet of the present invention.
• the kit may optionally contain instructions and the like describing the method of use and the like.
• the contact lens to which the cleaning sheet or kit of the present invention is used is not particularly limited, and a soft contact lens excellent in a feeling of wearing, a hard contact lens having high oxygen permeability, a non-hydrated contact lens, and the like. Can be mentioned.
• soft contact lenses Kuraray Medical Co., Ltd., trade name "Kuraray Soft Facinore”; frequency: 3,000, diameter: 14. Omm, base curve: 8, 70 mm
• hard contact lenses Kuraray Made from medical clay, trade name “Clara Supermarket EX”; frequency: 3,000, diameter: 8.8mm, base curve: 7 ⁇ 75mm (hereinafter, both may be referred to as contact lens)
• a process was performed to form a state equivalent to a state where the cleaning sheet was cleaned for one month.
• the treated contact lens was subjected to an extraction operation using physiological saline, and the resulting extract was subjected to a rabbit eye irritation test by the Draize method.
• the occurrence of bacteria during storage of the cleaning sheet was evaluated according to the Japanese Pharmacopoeia sterility test and preservation efficacy test.
• An artificial tear (2 mL) and a contact lens having the following composition were placed in a vial (5 mL) and immersed and heated (100 ° C) for 2 hours to prepare a protein-contaminated contact lens. .
• Ovalbumin 0.38 wt 0/0, lysozyme 0.12 wt 0/0, bovine serum gamma - globulin 10.16 wt% purified water balance.
• the cleaning power (%) of the contact lens with the cleaning sheet was calculated from X100, and the following value was obtained based on the value of the obtained cleaning power. According to the evaluation criteria, the cleaning effect of the cleaning sheet on protein stains was evaluated.
• the content of the bactericidal component or the preservative component in the cleaning sheet is calculated by the following formula:
• the dissolution amount of the sterilizing component or the preservative component was determined from the concentration of the sterilizing component or the preservative component in the physiological saline (ppm) ⁇ the amount of the physiological saline (mL). (5) Sterilization resistance
• the washing sheet was wrapped with a packaging material having autoclave resistance, subjected to autoclave sterilization at 121 ° C and 1.2 ⁇ 10 ° Pa for 40 minutes, and the sterilization resistance was evaluated according to the following evaluation criteria.
• the sheet material used as the support for the cleaning sheet was cut into about O.lg pieces, and the weight (W) was measured. 1.2% per lcm 2 of the sheet material before cutting
• Cleaning made for hard contact lenses (Kuraray Medical Co., Ltd., product name “Kuraray Super EX”; frequency: 3,000, diameter: 8.8 mm, base curve: 7,75 mm) according to the voluntary standards of the Contact Lens Association.
• a treatment was performed to form a state equivalent to a state where the cleaning sheet was washed for one month.
• the degree of breakage of the cleaning sheet after use for cleaning was evaluated according to the following evaluation criteria.
• a soft contact lens manufactured by Johnson & Johnson, trade name "2week Accu-Buichi”; frequency: 3,000, diameter: 14. Omm, base curve: 8.70 mm
• the degree of adhesion of fibers (lint) dropped from the cleaning sheet to the lens was evaluated according to the following evaluation criteria.
• EVAL Ethylene-modified polyvinyl alcohol
• E112YS E112YS, ethylene content 44 monoles, MI 12 gZlO content
• PP polypropylene
• EVAL Ethylene-modified polyvinyl alcohol
• PP polypropylene
• the cross section of the constituent fibers was non-round (more specifically, a flat square).
• Reference Example 2 Polypropylene (PP) (made by Idemitsu Petrochemical Co., Ltd., Y3002G, MI 30 g / 10 min) is used as the island component, and thermoplastic polyvinyl alcohol (made by Kuraray Co., Ltd., Exeval CP4104B2) is used as the sea component. : 30 islands of sea-island composite fiber filaments (fiber diameter 20 zm, cut length 5 mm) of 36 islands, knitted and knitted, then dissolve and remove sea components with hot water at 90 ° C to average fiber diameter of about 0.4 A knitted fabric (PP) with a basis weight of 85 gZm 2 , which has an ultrafine polypropylene fiber strength of ⁇ m, was produced.
• PP Polypropylene
• thermoplastic polyvinyl alcohol made by Kuraray Co., Ltd., Exeval CP4104B2
• polyethylene terephthalate (intrinsic viscosity 0.51 (measured with a mixed solvent of phenol Z and tetrachloroethane at an equal weight of 30 ° C))
• a knitted fabric was prepared in the same manner as in Reference Example 2 except that low-density polyethylene (Milson FL60, MI 70gZlO, manufactured by Mitsui Chemicals, Inc.) was used instead, and sea components were dissolved and removed with 90 ° C tonoleene.
• a knitted fabric (PET) with a basis weight of 85 g / m 2 made of ultrafine polyethylene terephthalate fiber having an average fiber diameter of about 0.4 ⁇ m was produced.
• Nylon 6 (Ube Industries, UBE Nippon, 1013BK1) was used in place of the polypropylene used in Reference Example 2, and an intrinsic viscosity of 0.51 (phenol / tetrachloroethane) was used in place of the thermoplastic polyvinyl alcohol.
• polyethylene terephthalate and nylon 6 were used at the respective ratios shown in Table 1 to prepare an 11-layer laminated fiber of polyethylene terephthalate and nylon 6, and a binder fiber [Co., Ltd. Kurarene earth manufactured by using Sofitto N720] in proportions shown in Table 1, subjected to paper making after hydroentanglement treatment, the average fiber diameter was produced about 1. 8 xm, wet spun lace having a basis weight of about 60gZm 2 (PET / Ny) . The cross section of the constituent fibers was non-round (more specifically, a flat square).
• the paper was subjected to a water entanglement treatment, and a wet spun lace ( ⁇ / ⁇ P) having an average fiber diameter of about 1.8 ⁇ and a basis weight of about 60 g / m 2 was produced.
• the cross section of the constituent fibers was non-round (more specifically, a flat square).
• a non-woven fabric made of cotton (Benlyse SP-204, manufactured by Asahi Kasei Fibers Ltd.) was used as a support.
• a cleaning solution having a composition shown in Table 2 below and containing no bactericidal component or antiseptic component was prepared and used without impregnating the nonwoven fabric or woven or knitted fabric, and (1) eye irritation of the cleaning solution was evaluated. Also, without using non-woven fabric or woven or knitted fabric, protein-contaminated contact lenses were rinsed with 3 mL of the cleaning solution, then immersed in 3 mL of the cleaning solution at room temperature for 4 hours, and (3) the cleaning effect of protein stain was evaluated. did. The results are shown in Table 3 below.
• Example 1 (g) (us (ig) SC then HC then SCL HG Example 1 1 0.100 0 0 0 0 None None None None None oo Example 2 3 0.375 0 0 0 0 None None None None None None oo Example 3 5 0.775 0 0 0 0 None None None None oo Example 4 1 0.010 0 0 0 0 None None None None oo Example 5 3 0.100 0 0 0 0 None None None None None oo Example 6 5 0.250 0 0 0 0 None None None None None o ⁇
• Example 7 3 0.360 0 0 0 0 None None None None None None oo Example 8 3 0.355 0 0 0 0 None None None None oo Example 9 3 0.360 0 0 0 0 None None None None None oo ⁇ Example 10 3 0.350 0 0 0 0 0 None None None None oo Example 1 1 3 0.360 0 0 0 0 None None
• the cleaning sheet obtained by impregnating a nonwoven fabric or a woven or knitted fabric with the cleaning liquid containing the hexamethylene biguanide derivative (PHMB) of Example 118, which is a product of the present invention has PHMB elution. It can be seen that the amount is small and the bacteria are not irritating, and the cleaning performance is excellent.
• PHMB hexamethylene biguanide derivative
• Comparative Examples 1 and 5 in which 50 ⁇ g of benzalkonium chloride was contained in the washing solution, the germicidal component migrated to the contact lens, causing eye irritation. Furthermore, in Comparative Example 2 in which the content of benzalkonium chloride was reduced to 5 ⁇ g as compared to Comparative Example 1, the benzalkonium salt was transferred to the contact lens, causing eye irritation. In Comparative Examples 3 and 6, in which sodium sorbate was contained in the cleaning solution at 700 / ig, sodium sorbate migrated to the contact lens, causing not only eye irritation, but also aseptic nonwoven or woven or knitted fabric. The nature is not secured.
• Comparative Examples 4 and 7 in which the cleaning solution did not contain any germicidal or antiseptic components, there was no eye irritation, but the sterility of the nonwoven or woven or knitted fabric was not ensured. In the case of Comparative Example 8, no cleaning effect was obtained.
• Examples 9 to 15 using PET / Ny ultrafine fibers high sterilization resistance was exhibited.
• Examples 9, 11, 12, 14, and 15 in which the composition ratio of PET / Ny is 2 / 1-1 / 2 show excellent water absorption, no breakage of the sheet was observed, and was excellent as a cleaning sheet. Performance.
• Examples 11, 12 and 14 in which the binder fiber was blended in an amount of 10 to 20% by weight no adhesion of lint was observed, the scratch resistance was good, and the most excellent performance as a cleaning sheet was exhibited. From the above, it is clear that the cleaning sheet of the present invention is very excellent as a means for cleaning a contact lens.

Landscapes

• Chemical & Material Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Wood Science & Technology (AREA)
• Health & Medical Sciences (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Organic Chemistry (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Dentistry (AREA)
• Veterinary Medicine (AREA)
• General Chemical & Material Sciences (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Physics & Mathematics (AREA)
• Public Health (AREA)
• Plant Pathology (AREA)
• Pest Control & Pesticides (AREA)
• Agronomy & Crop Science (AREA)
• Epidemiology (AREA)
• General Physics & Mathematics (AREA)
• Optics & Photonics (AREA)
• Ophthalmology & Optometry (AREA)
• Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
• Eyeglasses (AREA)
• Detergent Compositions (AREA)

Priority Applications (1)

Applications Claiming Priority (2)

Publications (1)

Family

ID=34805539

Family Applications (1)

Country Status (4)

Cited By (2)

Families Citing this family (1)

Citations (4)

• 2005
  • 2005-01-26 CN CNA200580003268XA patent/CN1914545A/zh active Pending
  • 2005-01-26 JP JP2005517309A patent/JPWO2005071467A1/ja not_active Withdrawn
  • 2005-01-26 WO PCT/JP2005/000956 patent/WO2005071467A1/ja active Application Filing
  • 2005-01-26 KR KR1020067017076A patent/KR20060111714A/ko not_active Application Discontinuation

Patent Citations (4)

Also Published As

Similar Documents

Legal Events