WO2008041439A1 - Préparation liquide pour lentilles de contact - Google Patents

Préparation liquide pour lentilles de contact Download PDF

Info

Publication number
WO2008041439A1
WO2008041439A1 PCT/JP2007/067128 JP2007067128W WO2008041439A1 WO 2008041439 A1 WO2008041439 A1 WO 2008041439A1 JP 2007067128 W JP2007067128 W JP 2007067128W WO 2008041439 A1 WO2008041439 A1 WO 2008041439A1
Authority
WO
WIPO (PCT)
Prior art keywords
contact lens
lens
solution
agent
tris
Prior art date
Application number
PCT/JP2007/067128
Other languages
English (en)
Japanese (ja)
Inventor
Osamu Mori
Yukihiro Kojima
Original Assignee
Menicon Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menicon Co., Ltd. filed Critical Menicon Co., Ltd.
Priority to JP2008537437A priority Critical patent/JPWO2008041439A1/ja
Publication of WO2008041439A1 publication Critical patent/WO2008041439A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A61L12/142—Polymeric biguanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/30—Amines; Substituted amines ; Quaternized amines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/32—Organic compounds containing nitrogen
    • C11D7/3209—Amines or imines with one to four nitrogen atoms; Quaternized amines

Definitions

  • the present invention relates to a contact lens solution, and in particular, when disinfecting, cleaning, and storing a contact lens, the contact lens sterilization solution, the contact lens sterilization cleaning solution, the contact lens sterilization storage solution, It is used as a sterilizing and washing solution for lenses, etc., which can ensure excellent bactericidal effect and safety, is excellent in lens compatibility, and effectively prevents protein adhering to the lens from being denatured.
  • This relates to contact lens solutions.
  • contact lenses are classified into non-hydrous contact lenses and hydrous contact lenses according to their materials, hard contact lenses and soft contact lenses, and They are classified into non-ionic contact lenses and ionic contact lenses.
  • microorganisms such as bacteria attached to the lens surface proliferate while the contact lens is removed from the eye and stored.
  • it is necessary to disinfect contact lenses before wearing them.
  • microorganisms such as bacteria propagate. Therefore, disinfection before wearing becomes important.
  • a contact lens solution conventionally, a solution containing a predetermined disinfectant (preservative) is used, and the contact lens is immersed in the solution, and the intended disinfection is performed. Processing has been carried out.
  • a bactericidal agent added to such a contact lens solution for example, a biguanide compound represented by polyhexamethylene biguanide (PHMB), benzalkonium chloride, polyquatemium, etc. Representative quaternary ammonium compound power It is widely used because it has particularly useful bactericidal properties compared to other fungicides.
  • PHMB polyhexamethylene biguanide
  • benzalkonium chloride polyquatemium
  • Representative quaternary ammonium compound power It is widely used because it has particularly useful bactericidal properties compared to other fungicides.
  • Patent Document 1 a non-ionic isotonic agent is equivalent to a predetermined concentration of sodium chloride together with 0.1 ppm to 10 ppm polyhexamethylene biguanide.
  • Patent Document 2 proposes a nonionic tonicity agent and / or a predetermined polyquaternium. Contact lens solutions containing amino acids have been proposed.
  • the bactericidal efficacy of the contact lens liquid can be improved, but depending on the nonionic tonicity agent and amino acid used, contact lenses ( In particular, the problem that the size of the contact lens changes due to expansion or contraction of the soft contact lens) and the standard of the contact lens changes is inherent.
  • JP-A-2001-242428 Patent Document 3
  • JP-A-2002-136578 Patent Document 4
  • an amino acid salt specifically, a sodium salt of an amino acid.
  • JP 2003-160482 A (Patent Document 5) describes a Bigud type or quaternary ammonium salt type fungicide, a predetermined amino acid (salt), a carboxyl group or a phosphate group.
  • a solution for contact lenses that contains a predetermined acidic compound and has a sodium chloride concentration of 0 to 0.2% by weight has been proposed.
  • the antibacterial agent can be prevented from adsorbing to the contact lens, and the safety to the eye can be secured to a high level, and the contact lens can be prevented from swelling or shrinking. It has been clarified that the problem of size change is solved advantageously.
  • Patent Document 6 2005/018693 (Patent Document 6) includes a big system and a 4th class ammonia.
  • a salt-based fungicide component A
  • a predetermined acidic compound component B
  • 2-amino-2-methinole-1,3-propanediol component C
  • AMPD 2-amino-2-methinole-1,3-propanediol
  • C salt thereof
  • tears which are secretions from the body, contain proteins (mainly lysozyme), but the strength of these proteins is relatively low in molecular weight. Since the point is on the alkali side, it exists in the tears with a positive charge. For this reason, the protein is attracted and attached to a contact lens having a negative charge.
  • a contact lens having a negative charge.
  • the roller force and other proteins penetrate not only into the lens surface but also into the lens, and adhere and accumulate inside the lens. Thus, it is difficult to completely remove proteins that have entered and adhered to the inside of the lens with a general cleaning component such as a surfactant.
  • the protein will gradually change due to external factors such as drying of the lens surface during wearing, contact with air, UV light, and body temperature. It has become clear that this protein denaturation causes various problems in wearing contact lenses. That is, if the protein is denatured, the wearing feeling of the contact lens deteriorates, the lens becomes cloudy, and the cornea is damaged, and the denatured protein causes allergy and causes allergic conjunctivitis. Comes to occur.
  • liquid for contact lenses is in direct contact with the eye, it is desired to use a less toxic component in order to improve safety for the eye. [0011] Therefore, even in the conventional contact lens solution as described above, from the viewpoint of improving lens compatibility, improving eye safety, and preventing protein denaturation that causes allergies. Further improvements are desired.
  • Patent Document 1 Japanese Patent Laid-Open No. 10-108899
  • Patent Document 2 Japanese Patent Laid-Open No. 11 249087
  • Patent Document 3 Japanese Patent Laid-Open No. 2001-242428
  • Patent Document 4 Japanese Patent Laid-Open No. 2002-136578
  • Patent Document 5 Japanese Unexamined Patent Publication No. 2003-160482
  • Patent Document 6 International Publication No. 2005/018693 Pamphlet
  • the present invention has been made against the background of power and the circumstances, and the problem to be solved is a lens while ensuring an excellent bactericidal effect and safety to eyes. It is an object of the present invention to provide a solution for a contact lens that prevents a change in the size of the lens and advantageously suppresses the denaturation of the protein adhering to the lens.
  • organic anions can be used in contact lens solutions containing biguanide or quaternary ammonium salt fungicides.
  • Tris an acidic compound that produces a tris (hydroxymethyl) aminomethane
  • an excellent bactericidal effect and safety can be secured, and the lens compatibility is excellent.
  • the protein attached to the lens can be effectively prevented from being denatured.
  • the present invention has been completed on the basis of strength and knowledge, and the gist thereof is at least selected from the group consisting of biguanide fungicides and ammonium salt fungicides.
  • a contact lens solution characterized by containing one type of bactericide, an acidic compound capable of producing an organic anion, and tris (hydroxymethyl) aminomethane.
  • the acidic compound and the tris (hydroxymethyl) aminomethane are in a molar ratio of 1:20 to; It is made to contain so that it may become a ratio.
  • the bactericide is contained so as to have a concentration of 0.;! To 500 ppm.
  • the acidic compound is contained so as to have a concentration of 0.01 to 5 w / w%.
  • the acidic compound is selected from the group consisting of glycolic acid, aspartic acid, glutamic acid, lactic acid, and kenic acid. At least one power S can be employed.
  • neutral amino acids are further contained.
  • the neutral amino acids are contained so as to have a concentration of 0.;! To 4w / w%.
  • glycine or taurine may be employed as the neutral amino acids.
  • a nonionic tonicity agent is further contained.
  • the nonionic tonicity agent has a concentration of 0.;! To lw / w%. Can be included.
  • propylene glycol may be employed as the nonionic tonicity agent.
  • an acidic compound that ionizes in an aqueous medium to generate an organic anion is used together with a biguanide fungicide or a quaternary ammonium salt fungicide. Therefore, the adsorption of the bactericidal agent to the contact lens is advantageously suppressed, and the safety for the eye becomes excellent! More specifically, the bactericidal agent is attached to or adhered to a contact lens (particularly, an ionic contact lens having a negative ion charge) when present in the form of a cation in an aqueous medium.
  • the liquid agent for contact lenses according to the present invention contains a specific bactericidal agent in an aqueous medium mainly composed of water, and further contains an acidic compound that generates an organic anion and tris (hydroxymethyl) aminomethane (Tris). Are combined and contained.
  • the bactericidal ability is excellent, the contact lens is excellent in adaptability to the eyes and the like, and further, it is difficult to cause a disorder such as allergy.
  • at least one kind or a combination of two or more kinds of conventionally known biguanide fungicides and quaternary ammonium salt fungicides will be used.
  • the biguanide fungicide achieves an excellent bactericidal effect even in small quantities that are less susceptible to bactericidal inhibition by other liquid ingredients (eg, acidic compounds) than quaternary ammonium salt fungicides. Therefore, it is used more advantageously.
  • PHMB polyhexamethylene biguanide
  • the quaternary ammonium salt fungicides include, for example, alkyl ammonium salts such as trialkylbenzil ammonium salts such as alkyltrimethyl ammonium monchloride; hydroxyethyl alkyl imidazoline Alkylhydroxyalkyl imidazoline quaternary salts typified by oral rides; alkylisoquinolinium salts typified by alkylisoquinolinium bromides; alkyl pyridinium salts; cationic surface activity such as amidoamines
  • X is a monovalent anion such as C1—
  • R 9 and R 10 are each independently represented by C n H m O p
  • X— is a monovalent anion such as C ⁇
  • the fungicide as described above is preferably used in a range of about 0.5 ppm to about 500 ppm, more preferably about 0.5 to 200 ppm, so that a particularly effective bactericidal effect or antiseptic is used.
  • the effect will be shown. If the content of such a bactericide is less than the lower limit of the above range, a sufficient bactericidal or antiseptic effect cannot be obtained, and if it exceeds 500 ppm, toxicity is increased.
  • there is a possibility of causing problems in terms of safety for example, adversely affecting the eyes, skin, etc., and promoting the adsorption of the bactericide on the contact lens surface.
  • the desired bactericidal efficacy can be advantageously realized even if the content of the bactericidal agent is kept low to be in the above range. Therefore, the safety for the eyes is remarkably excellent.
  • the contact lens solution according to the present invention has an essential component as one of the essential components.
  • An acidic compound that produces an anion is included.
  • This acidic compound is partially or completely ionized in an aqueous medium to form an organic anion, which allows the disinfectant present as a cation in the aqueous medium to adsorb to the contact lens. Since this acidic compound binds to the protein adhering to the lens surface or the surface layer portion and electrostatically interacts with the protein, the protein is peeled off from the lens. is there.
  • the occurrence of eye damage such as inflammation caused by bactericides and staining of the entire surface of the cornea is advantageously prevented, and the effects of drying, ultraviolet rays, etc. Removal of the protein adhering to the lens surface or the surface layer portion that is more susceptible to exposure is performed, and as a result, a high degree of safety for the eyes can be ensured.
  • the content of the acidic compound that generates the organic anion as described above is advantageously suppressed from being adsorbed on the bactericide power S contact lens, and can also exhibit the protein removal effect.
  • the acid compound in the concentration range of 0.0;! To 5 w / w% (weight%), more preferably 0.05 to 2 w / w%, the acid compound is determined as appropriate. Is preferably used. This is because if the content is too small, the effect of suppressing the adsorption of the bactericide to the lens and the effect of removing the protein cannot be expected, and if the content is too large, the contact lens shrinks and the size is reduced.
  • the acidic compound that produces the organic anion as described above does not decrease the bactericidal effect of the bactericidal agent, and can efficiently remove the protein in the surface layer portion, as well as to the eye.
  • Those having high safety can be advantageously used, and examples of such acidic compounds include glycolic acid, aspartic acid, glutamic acid, lactic acid, and citrate, and at least one of these can be cited.
  • Species are used alone or in combination of two or more.
  • crystals on the lens surface Glycolic acid, aspartic acid, and glutamic acid are more preferably used for the reason that there is little influence on the disinfectant with less precipitation.
  • the contact lens solution according to the present invention is further contained as one of the essential components of Tris force.
  • Tris When Tris is added to the liquid agent, since Tris is a basic compound, it has a positive ion charge in the aqueous medium, and in the state having the positive ion charge, It penetrates into the inside of the polymer and effectively suppresses the electrical repulsion between contact lens polymers having negative ion charges. As a result, even when applied to a type of soft contact lens that is particularly susceptible to size changes, lens size changes can be effectively prevented. Moreover, even if protein adheres to the contact lens, denaturation of the protein attached to the contact lens can be advantageously prevented by the Tris force ⁇ .
  • the contact lens solution according to the present invention contains Tris that generates an organic cation together with an acidic compound that generates an organic anion. Is effective, and a sufficient bactericidal effect can be secured even at low concentrations, and even when applied to a type of soft contact lens that tends to change in size, the change in lens size is more effective. Therefore, the lens compatibility is improved.
  • the cytotoxicity is lower than the conventional contact lens solution using 2-amino-2-methyl-1,3-propanepandiol (AMPD), which improves the safety to the eye. Allergic eye damage caused by the denatured protein can be prevented by advantageously preventing degeneration of the protein contained in the secretion from the body.
  • AMPD 2-amino-2-methyl-1,3-propanepandiol
  • the contact lens solution containing a bactericidal agent, an acid compound, and Tris as described above is immersed on the lens surface for a long period of time or is repeatedly applied to the lens surface.
  • the adhering protein can be removed advantageously, and even if the protein remains inside the lens without being removed, the protein will not be exposed to air, dryness, ultraviolet rays, body temperature effects, etc. As a result, it is possible to effectively prevent or suppress denaturation due to partial factors, and as a result, the onset of allergies caused by denatured proteins and the visibility of lenses caused by proteins that have become cloudy due to degeneration.
  • the reduced iso-force S can be advantageously prevented.
  • the content of Tris described above is determined as appropriate so that protein denaturation can be advantageously suppressed, by setting according to the amount of acidic compound used as described above,
  • the bactericidal effect of the bactericidal agent is advantageously expressed, an excellent bactericidal effect is obtained, and even when applied to a contact lens of a type in which a change in size is likely to occur, the change in size is more effectively suppressed, and the cell Toxicity is also reduced, and even better effects can be obtained, such as improved safety for the eyes.
  • the molar ratio of the acidic compound to Tris (acidic compound: Tris) force S that is, the force S used to be 1: 20-1.3: 1 is preferable.
  • the content power of Tris is 2 mol per 1 mol of acidic compound. If it exceeds 0 mol, it may not be possible to effectively prevent the disinfectant from adsorbing to the contact lens, and the content power of Tris against 1.3 mol of acidic compound If the amount is less than 1 mol, the bactericidal effect is reduced and the effect of preventing protein denaturation may be insufficient. Further, within the above range, in order to achieve the object of the present invention more effectively, it is preferably about 1: 15-; about 1.2: 1, more preferably 1: 10-; It is desirable to be about 1.
  • the contact lens solution according to the present invention containing a bactericide, an acidic compound and Tris as described above has been conventionally used to adjust osmotic pressure as an isotonic agent. It is desirable to contain sodium chloride as much as possible! /, And even if sodium chloride or the like is contained, the concentration is 0.2 w / w. % Or less, preferably, 0.1 lw / w% or less. In short, the content of sodium chloride is desirably 0 to 0.2 w / w%, preferably 0 to 0 lw / w%. This is because the sterilizing effect of the disinfectant is drastically lowered when the content of the sodium chloride content exceeds 0.2 w / w%, and the desired disinfecting effect may not be obtained. is there.
  • the contact lens solution according to the present invention usually has an osmotic pressure in consideration of physiological osmotic pressure so as not to irritate eyes or skin when used.
  • the concentration of the components contained in the liquid agent is appropriately set so as to be within a range substantially equal to the physiological osmotic pressure of about 250 to 400 mOsm / kg.
  • the contact lens solution according to the present invention contains, if necessary, an isotonic agent other than sodium chloride, specifically, neutral amino acids, nonionic tonicity agents, and the like. It is also possible to add and contain it, and by adding such an isotonic agent, the protein attached to the contact lens can be effectively prevented from being denatured, and the bactericidal effect of the bactericide is much more effective. To be expressed. Even when isotonic agents such as these neutral amino acids and nonionic tonicity agents are added, the amount added is quantitative so that the osmotic pressure of the solution does not exceed the expected value. It goes without saying that it is used in the range.
  • examples of the neutral amino acids described above include glycine, alanine, and tau.
  • Phosphorus, ⁇ -aminocaproic acid and the like can be mentioned, and one of these neutral amino acids can be used alone or in combination of two or more.
  • glycine and taurine can further effectively prevent the protein attached to the contact lens from being denatured and can assist the bactericidal action by the bactericidal agent.
  • the addition amount is preferably 0.
  • the concentration range be 4 w / w%, more preferably 0.3 to 2 w / w%. This is because when the amount added is less than 0.1 lw / w%, it is difficult to obtain the effect of addition (isotonic effect), and neutral amino acids are added in excess of 4 w / w%. In some cases, the osmotic pressure of the contact lens solution may be too high, or crystals may be deposited on the contact lens.
  • examples of the nonionic tonicity agent described above include propylene glycol, glycerin, saccharides and the like.
  • One of these nonionic tonicity agents can be used alone, Alternatively, two or more types can be used in combination. Further, by adding and adding such a nonionic tonicity agent to the contact lens solution according to the present invention, the lipophilicity of the solution is increased, and the occurrence of eye irritation is further advantageously suppressed. As a result, an even better feeling of use can be obtained and the cost of the liquid agent can be reduced.
  • propylene glycol is more preferably employed because it can increase the viscosity of the solution and advantageously reduce the occurrence of eye irritation.
  • the addition amount is preferably 0.;! To lw / w%, more preferably 0.3 to lw / It is desirable to use in the concentration range where w%. This is because if the amount used is less than 0.1 lw / w%, it is difficult to obtain an isotonic effect or a reduction effect on eye irritation by a nonionic tonicity agent. If added in excess of w%, the lens compatibility may be adversely affected.
  • the surfactant is used as a cleaning agent in order to advantageously impart a removal effect (cleaning effect) of dirt such as eye grease to the liquid for contact lenses according to the present invention. Added.
  • surfactants include, for example, polyglycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene / polyoxypropylene block copolymer, polyoxyethylene.polyoxypropylene. Ethylenediamine, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkylphenyl ether formaldehyde condensate, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkylphenyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene Sorbit fatty acid ester, polyoxyethylene castor oil, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyoxyethylene fatty acid ester, polyoxyethylene Polyoxypropylene alkyl ether, polyoxyethylene lanolin alcohol, polyoxyethylene alkylamine, polyoxyethylene alkylamide, polyoxyethylene alkyl ether phosphoric acid, polysorbate, etc. can be mentioned alone or in combination. Can be used.
  • the content of such a surfactant is generally about 0.001 to 5 w / w%, preferably about 0.005 to 2 w / w%, and more preferably Is from about 0.01 to about lw / w%. This is because if the amount added is too small, the resulting cleaning effect is insufficient, and if it is too large, the cleaning effect cannot be improved according to the amount added. This is because the cleaning effect does not change and may cause eye irritation.
  • the contact lens solution according to the present invention includes a metal chelating agent for preventing metal ions such as calcium in tears from adsorbing to contact lenses, particularly soft contact lenses.
  • Such metal chelating agents that are preferably incorporated include, for example, ethylene diamine tetraacetic acid (EDTA) and its salts, such as ethylene diamine tetraacetic acid 2 sodium (EDTA.2Na), ethylene diamine tetraacetic acid 3 sodium. (EDTA.3Na) Can give power S.
  • EDTA ethylene diamine tetraacetic acid
  • Such metal chelating agents are generally added at a rate of about 0.01 to;! ⁇ 0 w / w%.
  • the sodium chloride concentration power s in the liquid is 0.2 w / w% or less, preferably 0.1 lw / w% or less.
  • the liquid agent for contact lenses in the present invention may be added with a buffer in addition to the above pH adjuster. It is appropriately selected and used. Specifically, phosphate buffer, borate buffer, carbonate buffer, 2-amino-2-methylol 1,3-propane (AMP) buffer, and bis (2- Hydroxyethyl) iminotris (hydroxymethyl) methane (813-13 ⁇ 43), etc. 0 00 (1-81 ⁇ £ 6 etc.), especially safe for eyes and skin and less impact on contact lens
  • the addition amount of the force and the buffering agent is generally about 0.0 ;! to 2 w / w%, but it can be dissolved in water. When using buffering agents exhibiting a relatively large ionic strength, such as phosphates, the disinfecting ability of the disinfecting agent is determined by these buffering agents Therefore, it is desirable to make the addition amount zero or as low as possible.
  • the contact lens solution according to the present invention may be further added with a thickener as necessary.
  • a thickener for example, various gums such as heteropolysaccharides, synthetic organic polymer compounds, for example, Thickeners such as polybulol alcohol, poly (N-butylpyrrolidone), polyethylene glycol, polypropylene (polypropylene), polyacrylamide and the like, and further cellulose derivatives and starch derivatives can be appropriately used.
  • a contact lens solution according to the present invention containing a bactericidal agent, an acidic compound and Tris as described above, a special aqueous solution is prepared without any special method. Similarly to the case, each component can be easily obtained by increasing the melting angle in an aqueous medium such as purified water or distilled water.
  • the contact lens solution according to the present invention obtained as described above is, for example, a contact lens sterilization solution (disinfectant solution), a contact lens sterilization cleaning solution, a contact lens sterilization preservation solution, or a contact lens use solution. It is preferably used as a sterilization washing preservation solution or the like.
  • the contact lens solution according to the present invention can be used as an eye drop for contact lenses, etc., because excellent safety can be secured for eyes with low cytotoxicity. is there.
  • the contact lens removed from the eye is filled with the contact lens solution according to the present invention.
  • Disinfection is performed by immersing in a clean container for a predetermined time.
  • the contact lens is worn again, generally, the contact lens is taken out from the solution, washed, and then worn.
  • the sterilized contact lens is washed with physiological saline or the like.
  • this solution is safe for the eyes, it is possible to take out the contact lens immersed in this solution and apply it directly to the eye as it is.
  • disinfection of contact lenses using this solution may be performed after cleaning the contact lenses.
  • the contact lenses that are the target of the liquid for contact lenses are not limited in any kind, for example, soft contacts classified into all of non-water content, low water content, high water content, etc. Lenses and node contact lenses can be the object, and there is no question when applying the contact lens solution according to the present invention.
  • the contact lens solution according to the present invention is resistant to the disinfectant from being attached to the contact lens and has excellent lens compatibility, as well as denaturation of proteins that cause allergies attached to the contact lens. From the point that it can be advantageously controlled, soft contact lenses that are easily incorporated with disinfectants and dirt such as proteins and that are likely to cause a size change, especially the group that has traditionally been particularly likely to cause a size change. It can be applied particularly advantageously to ionic high water content soft contact lenses belonging to IV (US FDA classification).
  • a disinfectant used PHMB, which is a biguanide fungicide, or Polyquatayuum 1-4 and Polyquaterumum 22 which are quaternary ammonium salt fungicides.
  • aspartic acid, glutamic acid, or glycolic acid was used as an acidic compound (B in Table 1) that produces an organic anion.
  • Tris tris (hydroxymethyl) aminomethane
  • glycine or taurine was used as neutral amino acids
  • propylene glycol was used as a nonionic tonicity agent.
  • Tetronicl 07 (registered trademark, manufactured by BASF: ethylenediaminetetrapolyoxyethylenepolyoxypropylene) was used as the nonionic surfactant, and EDTA ′ 2Na was used as the metal chelating agent.
  • EDTA ′ 2Na 2-amino-2-methyl-1,3-propanediol (AMPD) was used in place of Tris for comparison.
  • AMPD 2-amino-2-methyl-1,3-propanediol
  • the egg white-derived lysozyme was added to each test solution (solution) so that the concentration was 0.24 w / w%, and the anti-denaturation effect when heat was applied was evaluated according to the following evaluation criteria.
  • the transmittance was measured by irradiating each test solution after heating with 700 nm visible light using an ultraviolet-visible spectrophotometer and measuring the light transmittance at that wavelength.
  • ⁇ The transmittance of the liquid when heated at 75 ° C for 60 minutes is 50% or less.
  • the liquid preparations of Experimental Examples 13 to 16 contain AMPD instead of Tris, and thus the protein denaturation prevention efficacy evaluation is ⁇ or X. Is denatured.
  • V79 cells (Chinese, Muster lung-derived fibroblasts) were seeded in a cell culture medium (MEM medium supplemented with 5 vol% fetal calf serum), cultured for 24 hours, and then Experimental Examples 1 to 16; Each solution was added to the culture solution so that the amount of each solution would be 5, 10, 20, and 30%, followed by further culturing for 1 week, and then the colony formation rate at each concentration was measured.
  • the colony formation rate was calculated according to the following formula.
  • Colony formation rate (%) at each concentration average number of colonies formed at each concentration ⁇ average number of colonies formed with negative control (culture medium only)
  • the measurement was performed using a projector (manufacturer: Nikon Corporation, model number: V12A) set at a rate.
  • the contact lenses taken out from the ISO physiological saline were immersed in the contact lens solution according to Experiment 1 16 maintained at 25 ° C, and the contact lenses were immersed in the immersed state.
  • the size (diameter: D) of the outer contour lens was measured. And got
  • the amount was calculated.
  • the lens compatibility was evaluated from the obtained lens size change amount according to the following evaluation criteria.
  • Number of bacteria reduced log (Number of viable cells in ImL immediately after preparation) log (Number of viable cells in ImL after treatment)
  • the bactericidal efficacy was evaluated from the value of the above-mentioned log reduction.
  • the evaluation criteria were “Yes” if the first criteria (related to sterilization) in IS014729 were satisfied, and “X” if not satisfied.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Eyeglasses (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne une préparation liquide pour lentilles de contact, dont l'effet bactéricide supérieur garantit une meilleure sécurité pour les yeux. Ladite préparation prévient tout changement de dimension de la lentille et présente une dénaturation avantageusement réduite des protéines adhérant à la lentille. La préparation liquide comprend au moins un agent antibactérien choisi dans le groupe constitué par un agent antibactérien biguanide et un agent antibactérien de sel d'ammonium ; un composé acide capable de générer un anion organique ; et du tris(hydroxyméthyl)aminométhane (Tris).
PCT/JP2007/067128 2006-09-29 2007-09-03 Préparation liquide pour lentilles de contact WO2008041439A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008537437A JPWO2008041439A1 (ja) 2006-09-29 2007-09-03 コンタクトレンズ用液剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006268055 2006-09-29
JP2006-268055 2006-09-29

Publications (1)

Publication Number Publication Date
WO2008041439A1 true WO2008041439A1 (fr) 2008-04-10

Family

ID=39268303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/067128 WO2008041439A1 (fr) 2006-09-29 2007-09-03 Préparation liquide pour lentilles de contact

Country Status (2)

Country Link
JP (1) JPWO2008041439A1 (fr)
WO (1) WO2008041439A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011064723A (ja) * 2009-09-15 2011-03-31 Nof Corp コンタクトレンズ用処理溶液
JP2012177901A (ja) * 2011-02-03 2012-09-13 Menicon Nect:Kk コンタクトレンズ用液剤
WO2024089166A1 (fr) * 2022-10-26 2024-05-02 Bausch + Lomb Ireland Limited Solution de traitement de lentilles de contact

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018693A1 (fr) * 2003-08-20 2005-03-03 Menicon Co., Ltd. Preparation liquide pour lentilles de contact
JP2006198001A (ja) * 2005-01-18 2006-08-03 Seed Co Ltd コンタクトレンズ用溶液

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018693A1 (fr) * 2003-08-20 2005-03-03 Menicon Co., Ltd. Preparation liquide pour lentilles de contact
JP2006198001A (ja) * 2005-01-18 2006-08-03 Seed Co Ltd コンタクトレンズ用溶液

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011064723A (ja) * 2009-09-15 2011-03-31 Nof Corp コンタクトレンズ用処理溶液
JP2012177901A (ja) * 2011-02-03 2012-09-13 Menicon Nect:Kk コンタクトレンズ用液剤
WO2024089166A1 (fr) * 2022-10-26 2024-05-02 Bausch + Lomb Ireland Limited Solution de traitement de lentilles de contact

Also Published As

Publication number Publication date
JPWO2008041439A1 (ja) 2010-02-04

Similar Documents

Publication Publication Date Title
EP1346021B1 (fr) Prevention de prise preservatrice dans des lentilles ophtalmiques
EP1734923B1 (fr) Composition de conservateur a base de zinc et procede d'utilisation
JP4255656B2 (ja) 眼科用液剤及びコンタクトレンズ用液剤
JP2000047156A (ja) コンタクトレンズ用殺菌液
KR20010031990A (ko) 알카리 탄산염을 포함하는 수용액을 이용한 콘택트 렌즈의처리 방법 및 조성물
JP2008510568A (ja) トリアルカノールアミン・アルコキシレートバッファー剤を含む組成物
JP2006509532A (ja) 生体材料および生物医学的デバイスへの細菌付着の減少
JP2009175543A (ja) コンタクトレンズ用液剤及びコンタクトレンズ並びにコンタクトレンズに対する殺菌剤の付着防止方法
JP3894945B2 (ja) コンタクトレンズ用液剤
US20040063620A1 (en) Compositions with enhanced antimicrobial efficacy against E. Coli
EP1812085A1 (fr) Compositions contenant des tampons a base de n,n,n',n'-tetrakis(hydroxyalkyl)diamine ou de n,n,n',n'-tetrakis(hydroxyalkoxy)diamine
JP5296953B1 (ja) 非イオン性ソフトコンタクトレンズ用消毒液
WO2008041439A1 (fr) Préparation liquide pour lentilles de contact
JPH0892017A (ja) コンタクトレンズ用液剤
AU2012253546B2 (en) Ophthalmic system with synergistic properties
WO2009096038A1 (fr) Agent liquide pour des lentilles de contact
EP0819968A1 (fr) Composition desinfectante/lavante pour lentilles de contact et procede de desinfection et de lavage de lentilles de contact a l'aide de cette composition
WO2003026420A1 (fr) Solutions bactericides
JP2008501026A (ja) 穏やかな保存組成物
JP4947895B2 (ja) コンタクトレンズケア用組成物
EP0175490A2 (fr) Compositions pour le traitement de lentilles de contact et utilisation de ces compositions
KR19990074047A (ko) 콘택트렌즈용 세척, 소독 및 보존제 조성물
JPH11322515A (ja) コンタクトレンズ用液剤
JP2002345929A (ja) コンタクトレンズ用の眼科用組成物
WO2014091575A1 (fr) Solution antiseptique pour lentille de contact souple ionique

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07806601

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008537437

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07806601

Country of ref document: EP

Kind code of ref document: A1