JP2006509532A - 生体材料および生物医学的デバイスへの細菌付着の減少 - Google Patents
生体材料および生物医学的デバイスへの細菌付着の減少 Download PDFInfo
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- JJHXBHDPYFGKLE-UHFFFAOYSA-O chloromethane;1-ethenyl-1h-imidazol-1-ium Chemical compound ClC.C=C[NH+]1C=CN=C1 JJHXBHDPYFGKLE-UHFFFAOYSA-O 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 150000007965 phenolic acids Chemical group 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000011354 prosthesis-related infectious disease Diseases 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000010301 surface-oxidation reaction Methods 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical group C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- FQDIANVAWVHZIR-OWOJBTEDSA-N trans-1,4-Dichlorobutene Chemical compound ClC\C=C\CCl FQDIANVAWVHZIR-OWOJBTEDSA-N 0.000 description 1
- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 description 1
- VZTGWJFIMGVKSN-UHFFFAOYSA-O trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium Chemical compound CC(=C)C(=O)NCCC[N+](C)(C)C VZTGWJFIMGVKSN-UHFFFAOYSA-O 0.000 description 1
- VUEZMURBIBNRIB-UHFFFAOYSA-O trimethyl-[3-methyl-3-(prop-2-enoylamino)butyl]azanium Chemical compound C[N+](C)(C)CCC(C)(C)NC(=O)C=C VUEZMURBIBNRIB-UHFFFAOYSA-O 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 238000012784 weak cation exchange Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
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- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
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- A—HUMAN NECESSITIES
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- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
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- A61L12/142—Polymeric biguanides
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/42—Amino alcohols or amino ethers
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
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Abstract
Description
本発明は、生体材料(生物医学的デバイス(例えば、コンタクトレンズ)が挙げられる)の表面への微生物の付着を阻害するための、方法および組成物に関する。
生体材料の表面への細菌の付着は、医療デバイス関連感染における寄与要因であると考えられる。感染を受けやすいことが見出されている医療デバイスの例としては、眼用レンズ(例えば、コンタクトレンズまたは眼内レンズ、眼内移植物、膜および他のフィルム)、カテーテル、マウスガード(mouth guard)、入れ歯のライナー(liner)、組織置換物、心臓弁などが挙げられ得る。多年の間進行中のこのようなデバイスの研究開発にも関わらず、種々の微生物が特定の生体材料またはデバイスに付着する程度は、予測困難なままである。
本発明は、生体材料および生物医学的デバイスの表面への微生物の付着を阻害および/または処理する際に使用するための、方法および組成物に関する。
本発明は、生体材料および生物医学的デバイスの表面への微生物の付着を阻害および/または処理するための、方法および対応する組成物に関する。
[a]その生物医学的デバイスの表面を、その生物医学的デバイスの表面上に反応性基を提供するために化学物質および組成物で前処理する工程;ならびに
[b]その表面上の反応性基を、水溶液中のポリエーテルと接触させる工程であって、その反応性基は、その水溶液中のポリエーテルと化学結合相互作用を形成するようになる、工程;
を包含する。
を包含する。
または点眼剤として処方され得、そしてサイズが1mlから30mlまでの広範囲の小容量容器中にで販売される。そのような容器は、HDPE(高密度ポリエチレン)、LDPE(低密度ポリエチレン)、ポリプロピレン、ポリ(エチレンテレフタレート)などから作製され得る。点眼剤について、従来の供給(dispensing)トップを有する弾性ボトルが、本発明とともに使用するために特に適切である。本発明の点眼剤処方物は、例えば、必要な場合に、眼に約1滴〜3滴滴下することによって、使用される。
特に、本発明において使用するために適切なポリクオタニウム(polyquaternium)ポリマーは、約5,000〜5,000,000、好ましくは約10,000〜500,000、最も好ましくは約20,000〜200,000の重量平均分子量を有する。
x=0〜5、y=0〜4、およびZ=0〜5であり、
Xは、Cl−、Br−、I−、HSO4 −、CHSO4 −、H2PO4 −、NO3 −である。
この実施例は、コンタクトレンズ表面への細菌の付着を減少させるような、親水性コンタクトレンズ上へのポリマーの結合効果を説明する。
ポリエーテル含有溶液の20mlのアリコートを、滅菌されたポリスチレンの使い捨てペトリ皿に注いだ。群IIIの延長装用コンタクトレンズ(PurevisionTM、Bausch & Lomb Incorporated、シリコーンヒドロゲル材料から作製され、そしてアニオン性の電荷を有する)を、滅菌ピンセットを用いて、それらのパッケージから取り出し、そして最初に滅菌された0.9%生理食塩水180mlに5回浸漬した。次いで、これらのレンズを、ポリエーテル含有溶液を含むペトリ皿内に配置し、そして室温で4時間浸漬した。4時間のインキュベーション時間の後に、これらのレンズを、滅菌ピンセットを用いてポリエーテル含有溶液から取り出し、そして最初に滅菌された0.9%生理食塩水の3回の連続的な充填(180ml)の各々に、それぞれ5回浸漬した。次いで、これらのレンズを、3mlの約108細胞/ml接種材料を含む20mlのガラスシンチレーションバイアルに移し、これを引き続いて、37℃でさらに2時間インキュベートした。
付着研究を、ポリエーテル含有溶液で処理した上記コンタクトレンズサンプルに対して、Sawantら(Sawant,A.D.,M.Gabriel,M.S.Mayo,およびD.G.Ahearn(1991)Radioopacity additives in silicone stent materials reduce in vitro bacterial adherence,Curr.Microbiol.22:285−292)oyobiGabrielra(Gabriel,M.M.,A.D.Sawant,R.B.Simmons,oyobiD.G.Ahearn(1995)Effects of Sliver on adherence of bacteria to urinary catheter:in vitro studies,Curr.Microbio.30:17−22)(これらの開示は、本明細書中に参考として援用される)の手順の改変に基づいて、実施した。
コンタクトレンズサンプルを、実施例に類似の様式で処理した。この実施例において、その処理溶液は、表2に列挙されるように、逆ポロキサマー(reverse poloxamer)であった。
Claims (20)
- 生物医学的デバイスの表面への細菌の付着を阻害するための方法であって、
該生物医学的デバイスの表面を、ポリエーテルを含む水溶液と接触させる工程、
を包含する、方法。 - 請求項1に記載の方法であって、前記生物医学的デバイスの表面を水溶液中の前記ポリエーテルと接触させる工程は、該生物医学的デバイス上での表面コーティングの形成をもたらす、方法。
- 請求項1に記載の方法であって、前記生物医学的デバイスは、眼用レンズである、方法。
- 請求項3に記載の方法であって、前記眼用レンズは、コンタクトレンズである、方法。
- 請求項4に記載の方法であって、前記コンタクトレンズは、シリコーンヒドロゲル物質から形成される、方法。
- 請求項1に記載の方法であって、前記水溶液は、約200mOsom/kg〜約400mOsom/kgのイオン強度を有する、方法。
- 請求項1に記載の方法であって、前記水溶液は、約240mOsom/kg〜約310mOsom/kgのイオン強度を有する、方法。
- 請求項1に記載の方法であって、前記水溶液は、抗菌剤、張度調整剤、緩衝剤、キレート剤、pH調整剤、および粘度改変剤からなる群より選択される1種以上の成分をさらに含む組成物である、方法。
- 請求項1に記載の方法であって、前記水溶液は、ポリマー性四級アンモニウム化合物をさらに含む、方法。
- 請求項9に記載の方法であって、前記水溶液は、カチオン性多糖をさらに含む、方法。
- 請求項1に記載の方法であって、前記ポリエーテルは、ポロキサマーである、方法。
- 請求項1に記載の方法であって、前記溶液は、コンタクトレンズを清浄にし、すすぎ、保存し、そして消毒するための、多目的コンタクトレンズ溶液である、方法。
- 請求項12に記載の方法であって、前記溶液は、消毒量の抗菌剤および緩衝剤をさらに含む、方法。
- 請求項13に記載の方法であって、前記抗菌剤は、ビグアナイド剤を含む、方法。
- 請求項13に記載の方法であって、前記溶液は、カチオン性セルロースポリマーをさらに含む、方法。
- 生物医学的デバイスの表面への細菌の付着を阻害するための方法であって、
該生物医学的デバイスの表面を、該生物医学的デバイスの表面上に反応性基を提供するために化学物質および組成物で前処理する工程;ならびに
該表面上の反応性基を、水溶液中のポリエーテルと接触させる工程;
を包含する、方法。 - コンタクトレンズの表面への細菌の付着を阻害するための方法であって、
該コンタクトレンズの表面にポリエーテル含有組成物を適用して、該コンタクトレンズの表面上に該ポリエーテルまたは該ポリエーテル組成物の表面コーティングを形成する工程、
を包含する、方法。 - 請求項17に記載の方法であって、前記ポリエーテルは、エチレンオキシド(EO)ブロックおよびプロピレンオキシド(PO)ブロックから構成されるブロックコポリマーから形成される、方法。
- 請求項18に記載の方法であって、前記ポリマーは、エチレンオキシド−プロピレンオキシド−エチレンオキシドブロックコポリマー、およびプロピレンオキシド−エチレンオキシド−プロピレンオキシドブロックコポリマーからなる群より選択される、方法。
- 請求項17に記載の方法であって、前記組成物は、
抗菌剤と、
張度調整剤、緩衝剤、キレート剤、pH調整剤、および粘度改変剤からなる群より選択される、少なくとも1種の構成要素と、
をさらに含む、方法。
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US41495802P | 2002-09-30 | 2002-09-30 | |
PCT/US2003/028400 WO2004030715A1 (en) | 2002-09-30 | 2003-09-10 | Bacterial attachment reduction to biomaterials and biomedical devices |
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JP2006509532A true JP2006509532A (ja) | 2006-03-23 |
JP2006509532A5 JP2006509532A5 (ja) | 2006-09-14 |
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JP2004541524A Pending JP2006509532A (ja) | 2002-09-30 | 2003-09-10 | 生体材料および生物医学的デバイスへの細菌付着の減少 |
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US (1) | US20060205621A1 (ja) |
EP (1) | EP1545641A1 (ja) |
JP (1) | JP2006509532A (ja) |
KR (1) | KR20050074464A (ja) |
CN (1) | CN1684722A (ja) |
AU (1) | AU2003270504A1 (ja) |
BR (1) | BR0314952A (ja) |
CA (1) | CA2500540A1 (ja) |
TW (1) | TW200418537A (ja) |
WO (1) | WO2004030715A1 (ja) |
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Also Published As
Publication number | Publication date |
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CA2500540A1 (en) | 2004-04-15 |
EP1545641A1 (en) | 2005-06-29 |
BR0314952A (pt) | 2005-08-02 |
KR20050074464A (ko) | 2005-07-18 |
WO2004030715A1 (en) | 2004-04-15 |
CN1684722A (zh) | 2005-10-19 |
US20060205621A1 (en) | 2006-09-14 |
TW200418537A (en) | 2004-10-01 |
AU2003270504A1 (en) | 2004-04-23 |
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