WO2009096038A1 - Agent liquide pour des lentilles de contact - Google Patents

Agent liquide pour des lentilles de contact Download PDF

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Publication number
WO2009096038A1
WO2009096038A1 PCT/JP2008/051658 JP2008051658W WO2009096038A1 WO 2009096038 A1 WO2009096038 A1 WO 2009096038A1 JP 2008051658 W JP2008051658 W JP 2008051658W WO 2009096038 A1 WO2009096038 A1 WO 2009096038A1
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WIPO (PCT)
Prior art keywords
contact lens
component
acid
concentration
agent
Prior art date
Application number
PCT/JP2008/051658
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English (en)
Japanese (ja)
Inventor
Osamu Mori
Original Assignee
Menicon Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menicon Co., Ltd. filed Critical Menicon Co., Ltd.
Priority to PCT/JP2008/051658 priority Critical patent/WO2009096038A1/fr
Publication of WO2009096038A1 publication Critical patent/WO2009096038A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A61L12/142—Polymeric biguanides

Definitions

  • the present invention relates to a contact lens solution, and more particularly to a contact lens solution in which the adsorption of a bactericidal agent to the contact lens is suppressed.
  • contact lenses are classified into hard contact lenses and soft contact lenses according to the material, non-hydrous contact lenses and hydrous contact lenses, and further non-ionic. It is classified into contact lenses and ionic contact lenses. Furthermore, in recent years, contact lenses using a new material, silicone hydrogel, have appeared, and various types of contact lenses have been widely used. If any of these contact lenses is used continuously, microorganisms such as bacteria attached to the lens surface may grow while the contact lens is removed from the eye and stored. Therefore, it is generally necessary to sterilize the contact lens before wearing it. In particular, in soft contact lenses, disinfection before wearing is extremely important because microorganisms such as bacteria are easy to propagate.
  • Such contact lenses are generally sterilized by using a solution containing a predetermined disinfectant (disinfectant), and immersing the contact lens after wearing in a solution containing the disinfectant. The sterilization process is carried out.
  • a bactericidal agent added to such a contact lens solution for example, a biguanide bactericidal agent represented by polyhexamethylene biguanide (PHMB), benzalkonium chloride, polyquaternium (Polyquaternium), etc.
  • PHMB polyhexamethylene biguanide
  • benzalkonium chloride polyquaternium
  • Polyquaternium polyquaternium
  • Representative ammonium salt fungicides are widely used because they have particularly useful fungicidal properties compared to other fungicides.
  • Patent Document 1 a biguanide cationic disinfectant and a polyquaterium-based antibacterial agent are provided for the purpose of providing a contact lens solution having sufficiently high disinfection efficacy and low toxicity to the eye.
  • a contact lens solution containing an amino acid and / or an amino acid salt as an isotonic agent together with a bactericidal agent has been proposed.
  • Patent Document 1 discloses that the bactericidal effect of a liquid agent for contact lenses can be enhanced by adding a borate buffer as a pH buffer.
  • Patent Document 2 Japanese Patent Publication No. 6-49642
  • Patent Document 2 it has been clarified that the disinfecting effect can be enhanced by combining a biguanide and a boric acid buffer. Test) to confirm the disinfection effect by changing the concentration.
  • Patent Document 2 no study is made on the deterioration of cytotoxicity caused by the borate buffer.
  • Patent Document 3 discloses a tertiary amino group and a quaternary ammonium group for the purpose of providing a composition for contact lenses that imparts antifouling properties simultaneously with cleaning.
  • a contact lens composition containing a polymer compound for preventing protein adhesion is proposed, and in the examples, together with the polymer compound for preventing protein adhesion, polyhexamethylene biguanide hydrochloride, boric acid, borax.
  • a composition containing sodium aspartate, sodium glutamate and the like has been clarified.
  • the compositions disclosed in Patent Document 3 are all for improving the antifouling property, and there is no disclosure of a technique for achieving both a conflicting bactericidal effect and safety for eyes. Absent.
  • Patent Document 4 discloses a bactericidal agent for contact lenses using the component B. It has been clarified that the adsorbing of water can be suppressed, and the decrease in the bactericidal efficacy is suppressed by the C component, so that a good bactericidal efficacy can be obtained.
  • AMPD has a problem that the raw material cost is high, and as a result, the product cost of the liquid preparation for contact lenses is high, and further improvement is required for the disinfection effect and safety. It is.
  • the present invention has been made in the background of such circumstances, and the problem to be solved is that the adsorption of the bactericide to the contact lens can be advantageously prevented and the cytotoxicity is low. And it is providing the liquid agent for contact lenses in which the disinfection effect was improved at low cost.
  • the gist of the present invention is that (A) at least one fungicide selected from the group consisting of a biguanide fungicide and an ammonium salt fungicide, and (B) 25 mM. At least one acidic compound selected from the group consisting of glycolic acid, aspartic acid, glutamic acid and salts thereof at a concentration of ⁇ 250 mM, and (C) boric acid and borax at a concentration of 20 mM to 90 mM in terms of boric acid And at least one boric acid selected from the group consisting of borates and a boric acid salt solution.
  • the molar ratio of the B component and the C component is 1: 3 to 5: 1.
  • the component A is contained so as to have a concentration of 0.1 to 500 ppm.
  • neutral amino acids are further contained.
  • Such neutral amino acids advantageously contain glycine.
  • a nonionic tonicity agent is further contained.
  • propylene glycol is advantageously contained.
  • polyhexamethylene biguanide is preferably contained as the biguanide fungicide.
  • the contact lens solution according to the present invention at least one selected from the group consisting of glycolic acid, aspartic acid, glutamic acid and salts thereof together with a biguanide-based or ammonium salt-based bactericidal agent (component A). Since the acidic compound (B component) of the seed is contained at a predetermined concentration, the adsorption of the bactericide (A component) to the contact lens can be effectively suppressed, and the bactericidal agent (A component) Even if the sterilization or disinfection effect is inhibited by the acidic compound (component B), the decrease in the sterilization or disinfection effect can be suppressed as much as possible.
  • a biguanide-based or ammonium salt-based bactericidal agent component A
  • the contact lens solution according to the present invention includes at least one selected from the group consisting of boric acid, borax, and borate in addition to the bactericidal agent (component A) and acidic compound (component B).
  • Boric acids (component C) are contained, even if the disinfection or disinfection effect of the bactericidal agent (component A) is inhibited by the acidic compound (component B), the boric acids (component C) In addition, an excellent sterilization or disinfection effect can be expressed.
  • the boric acids (component C) are contained at a low concentration, the cells can be used in spite of the high sterilization or disinfection effect. It has low toxicity and has improved safety for the eyes compared to conventional liquids containing boric acid.
  • boric acids component C
  • AMPD 2-amino-2-methyl-1,3-propanediol
  • the liquid for contact lenses according to the present invention contains (A) a specific bactericidal agent in an aqueous medium mainly composed of water, and (B) a specific acidic compound and (C) boric acids. It is configured by being combined and contained.
  • the disinfectant (component A) is excellent in disinfecting or disinfecting ability, excellent in compatibility with contact lenses, eyes, etc., and further difficult to cause a disorder such as allergy.
  • the various conventionally known biguanide fungicides and ammonium salt fungicides at least one or two or more of them are used in combination.
  • biguanide fungicides are less susceptible to sterilization inhibition by other liquid component components (for example, acidic compounds) than ammonium salt fungicides, and have excellent sterilization or disinfection effects even in small amounts. Can be used more advantageously.
  • examples of the biguanide bactericides include polyhexamethylene biguanide (PHMB) and biguanide polymers represented by the following structural formula (I).
  • ammonium salt fungicide examples include, for example, alkylammonium salts such as tetraalkylammonium salts such as alkyltrimethylammonium chloride and trialkylbenzylammonium salts such as octadecyldimethylbenzylammonium chloride; and hydroxyethylalkylimidazoline chloride.
  • alkylammonium salts such as tetraalkylammonium salts such as alkyltrimethylammonium chloride and trialkylbenzylammonium salts such as octadecyldimethylbenzylammonium chloride; and hydroxyethylalkylimidazoline chloride.
  • alkyl hydroxyalkyl imidazoline quaternary salts alkyl isoquinolinium salts typified by alkyl isoquinolinium bromides; alkyl pyridinium salts; cationic surfactants such as amidoamines as well as the following structural formulas (II) to A quaternary ammonium polymer represented by (IV), a condensate of a diamine and a dihalogen compound, as disclosed in Japanese Patent No. 2550036, JP-A-4-231044 Examples thereof include polycationic compounds disclosed in Japanese Patent Laid-Open No. 8-512145, JP-A-11-249087, and benzalkonium halides.
  • the bactericidal agent (component A) as described above is preferably used in a range of about 0.1 to 500 ppm, more preferably about 0.5 to 100 ppm, so that a particularly effective bactericidal effect (disinfecting effect). Will be shown.
  • the desired bactericidal efficacy can be advantageously realized even if the content of the bactericidal agent is kept low to be in the above range.
  • the safety for the eyes is remarkably excellent.
  • the content of such a bactericidal agent is less than the lower limit of the above range, a sufficient bactericidal effect cannot be obtained, and when it is too much, toxicity is increased, for example, the eye etc.
  • a problem may occur in terms of safety, such as an adverse effect on the surface of the contact lens and the adsorption of the bactericide on the contact lens surface.
  • the contact lens solution according to the present invention contains a specific acidic compound as component B.
  • a specific acidic compound as component B.
  • an acidic compound at least one of glycolic acid, aspartic acid, glutamic acid and salts thereof (for example, sodium salt, potassium salt, etc.) is used alone or in combination of two or more. Will be.
  • This acidic compound (component B) is partly or wholly ionized in an aqueous medium to produce an organic anion, and this organic anion becomes a cation in the aqueous medium, and a bactericide (component A) ),
  • the adsorption of the bactericide (component A) to the contact lens can be extremely effectively suppressed.
  • glycolic acid has a low molecular weight compared to other materials, so even if the blending amount (w / w%) is small, the antibacterial agent (component A) has a high effect of preventing adhesion to contact lenses. Therefore, it can be particularly suitably employed because it has the advantage that the raw material cost and thus the product cost of the contact lens solution can be kept low by the amount that can be reduced (w / w%). .
  • the content of the acidic compound (component B) is 25 mM to 250 mM in terms of molar concentration so that the bactericidal agent (component A) can be advantageously prevented from adsorbing to the contact lens.
  • the concentration range is 30 mM to 200 mM.
  • At least one boric acid selected from the group consisting of boric acid, borax and borate is used alone or in combination of two or more as the C component.
  • the borate include sodium borate, potassium borate, sodium tetraborate, and potassium tetraborate.
  • the adhesion of the bactericidal agent (A component) to the contact lens is effectively suppressed.
  • excellent safety to the eyes can be secured, while the sterilization or disinfection effect of the bactericidal agent (component A) tends to be inhibited by the acidic compound (component B).
  • acids (C component) By combining acids (C component), the sterilization or the reduction of the disinfection effect can be supplemented advantageously.
  • the said boric acid functions also as a pH buffer, it contributes also to the pH stability of the liquid agent for contact lenses.
  • boric acids are inexpensive materials, it is possible to keep raw material costs and, in turn, product costs of contact lens solutions low.
  • the content of such boric acids is a molar concentration in terms of boric acid, in a range of 20 mM to 90 mM, preferably 30 mM to 90 mM.
  • the reason for this is that if the content of boric acid is less than 20 mM in terms of boric acid, the effect of addition cannot be sufficiently obtained, and the sterilization or disinfection effect cannot be sufficiently supplemented, and the boric acid is used. This is because the pH buffering action cannot be expressed. On the other hand, when it exceeds 90 mM, the cytotoxicity of the liquid for contact lenses is increased, which may cause adverse effects on the eyes.
  • said "boric acid conversion” means converting borax and borate into the quantity of boric acid. For example, when borax is used, 1 mol of borax is converted into boric acid. This corresponds to 4 moles.
  • the content of the boric acid (component C) is not particularly limited as long as it is within the above-mentioned concentration range, but is preferably set according to the content of the acidic compound (component B).
  • the molar ratio of the acidic compound (component B) and boric acids (component C) (component B: component C) is preferably 1: 3 to 5: 1, more preferably 1 : 2.5 to 4.5: 1. This is because when the content of boric acid (C component) is too much with respect to the acidic compound (B component), the acidic compound (B component) can sufficiently exert the effect of preventing the disinfectant from attaching to the contact lens. If the content of boric acids (component C) is too small relative to the acidic compound (component B), it sufficiently supplements the sterilization or reduction of the disinfection effect. This is because there is a possibility that sufficient sterilization or disinfection effects cannot be obtained.
  • At least one of glycolic acid, aspartic acid, glutamic acid, and salts thereof, among the acidic compounds that generate organic anions as the B component is a predetermined component.
  • at least one of boric acid, borax, and borate as a C component is contained at a predetermined concentration.
  • Adhesion of (A component) is advantageously prevented, and even if the bactericidal effect of such a bactericidal agent (A component) is inhibited by an acidic compound (B component), boric acids (C component) compensate for it and The bactericidal effect can be realized.
  • the concentration of boric acids (component C) is kept as low as 20 mM to 90 mM, the cytotoxicity is low, and the safety to the eye is enhanced compared to conventional liquids containing boric acid. It is.
  • the contact lens solution according to the present invention containing the components A to C as described above may contain neutral amino acids and nonionic tonicity agents as necessary. is there.
  • the contact lens solution according to the present invention has a osmotic pressure of usually 250 to 400 mOsm / kg in consideration of physiological osmotic pressure so as not to irritate eyes when it is used. More preferably, the concentrations of various components are appropriately set so as to be within a range substantially equal to physiological osmotic pressure of about 250 to 350 mOsm / kg.
  • examples of the neutral amino acids include glycine, alanine, taurine, ⁇ -aminocaproic acid and the like.
  • One of these neutral amino acids can be used alone, or two or more can be used. They can be used in combination. Then, by adding and adding such neutral amino acids to the contact lens solution according to the present invention, the effects as described above according to the present invention can be exhibited more advantageously.
  • glycine is particularly preferably used because it has little influence on the size change of the contact lens.
  • the content is preferably in a concentration range of 0.1 to 4 w / w%, more preferably 0.3 to 2 w / w%. It is desirable. This is because when the content is too small, the effect of addition (isotonic effect) becomes difficult to obtain, and when there are too many neutral amino acids, the osmotic pressure of the contact lens solution is high. This is because there is a risk of becoming too much.
  • nonionic tonicity agent examples include propylene glycol, glycerin, saccharides and the like.
  • these nonionic tonicity agents can be used alone, or two or more can be used. They can be used in combination.
  • the occurrence of eye irritation is further advantageously suppressed, which is even better.
  • a feeling of use can be obtained.
  • propylene glycol is more preferable because it can adjust the liquid for contact lenses to a physiological osmotic pressure at a relatively low concentration and can advantageously reduce the occurrence of eye irritation. Adopted.
  • the content is preferably 0.1 to 4 w / w%, more preferably 0.3 to 2 w / w%. It is desirable to be used in a certain concentration range. This is because if the content is too small, it is difficult to obtain an isotonic effect or a reduction effect on eye irritation by a nonionic tonicity agent, and if it is too much, it is suitable for lens adaptation. This is because there is a risk of adverse effects on sex.
  • a surfactant for example, a surfactant, a metal chelating agent, a pH adjusting agent, a buffering agent, a thickener, etc. are conventionally used.
  • Various known additives that are added to and contained in the liquid preparations can be appropriately selected and incorporated, and there is no problem.
  • any conventionally known additives can be used as long as they are highly safe to living bodies and do not affect the shape or physical properties of the contact lens. In the quantitative range that does not impair the action and effect of, it is advantageously added and contained.
  • the surfactant is added as a cleaning agent in order to advantageously impart a removal effect (cleaning effect) of dirt such as eye grease to the contact lens solution according to the present invention.
  • surfactants include, for example, polyglycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene / polyoxypropylene block copolymer, polyoxyethylene / polyoxypropylene ethylenediamine, and polyoxyethylene sorbitan.
  • Fatty acid ester polyoxyethylene alkyl phenyl ether formaldehyde condensate, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl phenyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene castor oil, polyoxyethylene Sterol, polyoxyethylene hydrogenated sterol, polyoxyethylene fatty acid ester, polyoxyethylene Examples thereof include oxypropylene alkyl ether, polyoxyethylene lanolin alcohol, polyoxyethylene alkylamine, polyoxyethylene alkylamide, polyoxyethylene alkyl ether phosphoric acid, polysorbate and the like, and can be used alone or in combination. .
  • the content of such a surfactant is generally about 0.001 to 5 w / w%. This is because if the amount added is too small, the resulting cleaning effect will be insufficient, and if it is too large, improvement in the cleaning effect corresponding to the amount added will not be obtained. This is because the effect does not change and may cause eye irritation.
  • the metal chelating agent is added in order to prevent metal ions such as calcium in tears from adsorbing to contact lenses, particularly soft contact lenses.
  • metal chelating agents include ethylenediaminetetraacetic acid (EDTA) and salts thereof, such as ethylenediaminetetraacetic acid.2 sodium (EDTA.2Na), ethylenediaminetetraacetic acid.3 sodium (EDTA.3Na), and the like.
  • EDTA ethylenediaminetetraacetic acid
  • Such metal chelating agents are generally added at a ratio of about 0.01 to 1.0 w / w%.
  • the pH adjusting agent or buffering agent has a pH value of 4.0 to 9.0, preferably, so as not to cause irritation or damage to the eye. It is advantageously used for adjusting to 6.0 to 8.0, especially around 7.0.
  • examples of the pH adjuster include sodium hydroxide, potassium hydroxide, hydrochloric acid, and the like, which are appropriately selected and used.
  • phosphate buffer, carbonate buffer, tris (hydroxymethyl) aminomethane (Tris) buffer, 2-amino-2-methyl 1,3-propane (AMP) buffer, 2-amino-2-methyl-1,3-propanediol (AMPD) buffer, bis (2-hydroxyethyl) iminotris (hydroxymethyl) methane (Bis-Tris) Good-Buffer, etc. can be exemplified particularly because it is safe for the eyes and skin and can reduce the influence on the contact lens, and is added as necessary.
  • the thickener is blended in order to adjust the viscosity of the liquid for contact lenses and improve the feeling of use.
  • various gums such as heteropolysaccharides, synthetic organic Polymer compounds such as polyvinyl alcohol, poly-N-vinyl pyrrolidone, polyethylene glycol, polypropylene glycol, polyacrylamide and the like, and further cellulose derivatives and starch derivatives can be used as appropriate.
  • a contact lens solution according to the present invention which contains a bactericidal agent (component A), an acidic compound (component B), and boric acids (component C) as described above, any special method is required. Instead, it can be easily obtained by dissolving each component in an aqueous medium such as purified water or distilled water, as in the case of preparing an ordinary aqueous solution.
  • component A bactericidal agent
  • component B an acidic compound
  • boric acids component C
  • the contact lens solution according to the present invention obtained as described above is, for example, a contact lens sterilization liquid (disinfection liquid), a contact lens sterilization cleaning liquid, a contact lens sterilization preservation liquid, or a cleaning process or a rinsing process. Therefore, it is preferably used as a multi-purpose solution (MPS) or the like that can perform all of the disinfection processing and the storage processing. Moreover, since the concentration of boric acids (component C) is kept low compared with conventional solutions, the liquid for contact lenses according to the present invention has low cytotoxicity and safety for eyes can be secured. Therefore, it can be used as a contact lens mounting agent, a contact lens eye drop, or the like.
  • MPS multi-purpose solution
  • the contact lens removed from the eye is appropriately filled with the contact lens solution according to the present invention.
  • Disinfection is performed by immersing in a container for a predetermined time.
  • the contact lens is worn again, generally, the immersed contact lens is taken out from the solution, washed, and then worn. In such wearing, the sterilized contact lens is washed with physiological saline.
  • this solution is safe for the eyes, it is possible to take out the contact lens soaked in this solution and apply it directly to the eye as it is. is there.
  • disinfection of contact lenses using this solution may be performed after the contact lenses are cleaned.
  • the type of contact lens that is the target of the contact lens solution is not limited in any way, and includes, for example, soft contact lenses classified into all of non-water content, low water content, high water content, and the like.
  • the contact lens can be the object, and the material of the contact lens is not questioned when the contact lens solution according to the present invention is applied.
  • the contact lens solution according to the present invention is a contact lens in which a bactericidal agent is not easily attached to a contact lens, and particularly, a contact lens that is easy to incorporate a bactericidal agent, particularly an ionic high water content belonging to Group IV (US FDA classification). It can be applied particularly advantageously to soft contact lenses and silicon hydrogel lenses.
  • predetermined additive components were added to sterilized purified water at various ratios shown in Tables 1 and 2 below, and the contact lens solutions according to Examples 1 to 12 and Comparative Examples 1 to 16, respectively. Each was prepared.
  • PHMB which is a biguanide type fungicide is used as the A component
  • aspartic acid glutamic acid or glycolic acid is used as the B component
  • boric acid and borax are used as the C component.
  • glycine was used as neutral amino acids
  • propylene glycol was used as a nonionic tonicity agent.
  • citric acid was used in a ratio of 67.7 mM in place of the component B.
  • the bactericidal efficacy test was conducted in accordance with the stand-alone test of ISO 14729. Specifically, each 9.9 mL of each solution is put into a test tube, and as a test bacterium, Staphylococcus aureus (IFO 13276) or Candida albicans IFO 1594 ) was added with 0.1 mL of a bacterial solution containing 10 8 to 10 9 cfu / mL and stirred, and finally a bacterial suspension containing 10 6 to 10 7 cfu / mL of bacterial cells was prepared. Then, after leaving them at 23 ° C.
  • bactericidal effect was evaluated from the value of the above-mentioned log reduction (log reduction) by the following evaluation criteria.
  • the dyed lens of 2 was immersed in 7 mL of ethanol for about 30 seconds to remove excess EosinY adhering to the contact lens. 4).
  • the obtained contact lens is immersed in JP physiological saline to adjust the lens state, and using a spectrophotometer, the measurement wavelength region: 450 to 600 nm, slit width: 12 nm, measurement mode: ABS conditions Then, the absorption spectrum of the contact lens was measured. 5). Then, a value X obtained by subtracting the absorbance at the maximum absorption wavelength of the absorption spectrum of the new lens from the absorbance at the maximum absorption wavelength of the absorption spectrum of the contact lens immersed in an aqueous solution of PHMB only (Comparative Example 12) was obtained.
  • IC 50 concentration of each liquid when the plating efficiency is approximately 50%
  • the solution containing the bactericide contains a predetermined acidic compound (component B) and boric acids (component C),
  • component B a predetermined acidic compound
  • component C boric acids
  • the contact lens solution according to Examples 1 to 12 contained at a predetermined concentration, the bactericidal effect on Staphylococcus aureus and Candida albicans, the adsorption inhibitory effect of the bactericide on the contact lens, and the evaluation of cytotoxicity
  • both are good and have good bactericidal effect and good safety for eyes.
  • the comparative example 1 in which the concentration of the acidic compound (component B) exceeds 250 mM is clear as compared with the comparative example 12 containing only the germicide (component A), and the germicide (component A).
  • the sterilizing effect is reduced, the osmotic pressure is high, and the cytotoxicity is also increased.
  • Comparative Examples 2 to 4 where the concentration of boric acid (component C) is less than 20 mM the bactericidal effect against Candida albicans is ⁇ or ⁇ , and the bactericidal effect of the bactericidal agent (component A) is boric acid. It can be seen that (C component) is not sufficiently supplemented.
  • Comparative Examples 5, 6 and 8 in which the concentration of the acidic compound (component B) is less than 25 mM, and Comparative Examples 12 to 14 to which no acidic compound (component B) is added are sterilized against the contact lens. It can be seen that the agent is easily adsorbed. Further, Comparative Examples 7, 10 and 11 in which the concentration of boric acids (C component) exceeds 90 mM have high cytotoxicity. Further, in Comparative Example 9 containing citric acid instead of the B component, the bactericidal effect against Candida albicans is reduced. In addition, in both Comparative Examples 15 and 16, the bactericidal effect against Candida albicans is x, and the bactericidal effect of the bactericidal agent (component A) is reduced.

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Abstract

L'invention vise à proposer à moindre coût un agent liquide pour des lentilles de contact, qui peut avantageusement empêcher un désinfectant d'être adsorbé sur la lentille de contact et qui a une faible cytotoxicité et qui présente également un effet de désinfection amélioré. On a préparé l'agent liquide pour lentille de contact contenant (A) au moins un type de désinfectant choisi dans le groupe constitué par les désinfectants à base de biguanide et les désinfectants à base de sels d'ammonium ; (B) au moins un type de composé acide choisi dans le groupe constitué par l'acide glycolique, l'acide aspartique, l'acide glutamique et les sels de ceux-ci à une concentration de 25 mM à 250 mM ; et (C) au moins un type de composé d'acide borique choisi dans le groupe constitué par l'acide borique, le borax et les borates à une concentration de 20 mM à 90 mM en termes d'acide borique.
PCT/JP2008/051658 2008-02-01 2008-02-01 Agent liquide pour des lentilles de contact WO2009096038A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011084520A (ja) * 2009-10-15 2011-04-28 Rohto Pharmaceutical Co Ltd ソフトコンタクトレンズ用眼科組成物
JP2016194704A (ja) * 2010-07-06 2016-11-17 ロート製薬株式会社 コンタクトレンズケア用組成物
WO2022159829A1 (fr) * 2021-01-23 2022-07-28 Brim Biotechnology, Inc. Compositions comprenant des peptides courts dérivés de pedf (pdsp) et leurs utilisations

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