WO2005009947A3 - Produits aryl-heteroaromatiques, compositions les contenant et utilisation - Google Patents

Produits aryl-heteroaromatiques, compositions les contenant et utilisation Download PDF

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Publication number
WO2005009947A3
WO2005009947A3 PCT/FR2004/001944 FR2004001944W WO2005009947A3 WO 2005009947 A3 WO2005009947 A3 WO 2005009947A3 FR 2004001944 W FR2004001944 W FR 2004001944W WO 2005009947 A3 WO2005009947 A3 WO 2005009947A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
same
aryl
heteroaromatic products
products
Prior art date
Application number
PCT/FR2004/001944
Other languages
English (en)
Other versions
WO2005009947A2 (fr
Inventor
Patrick Mailliet
Alain Le-Brun
Fabienne Thompson
Gilles Tiraboschi
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Priority to AU2004259112A priority Critical patent/AU2004259112A1/en
Priority to EP04785992A priority patent/EP1651602A2/fr
Priority to MXPA06000479A priority patent/MXPA06000479A/es
Priority to CA002533494A priority patent/CA2533494A1/fr
Priority to JP2006520863A priority patent/JP2006528615A/ja
Priority to BRPI0412254-2A priority patent/BRPI0412254A/pt
Publication of WO2005009947A2 publication Critical patent/WO2005009947A2/fr
Publication of WO2005009947A3 publication Critical patent/WO2005009947A3/fr
Priority to IL173205A priority patent/IL173205A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Produits aryl-hétéroaromatiques, compositions les contenant et utilisation. La présente invention concerne notamment de nouveaux produits aryl-hétéroaromatiques présentant une activité anticancéreuse, et en particulier une activité inhibitrice de polymérisation de la tubuline.
PCT/FR2004/001944 2003-07-24 2004-07-22 Produits aryl-heteroaromatiques, compositions les contenant et utilisation WO2005009947A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2004259112A AU2004259112A1 (en) 2003-07-24 2004-07-22 Aryl heteroaromatic products, compositions comprising the same and use thereof
EP04785992A EP1651602A2 (fr) 2003-07-24 2004-07-22 Produits aryl-heteroaromatiques, compositions les contenant et utilisation
MXPA06000479A MXPA06000479A (es) 2003-07-24 2004-07-22 Productos aril-heteroaromaticos, composiciones que los contienen y utilizacion.
CA002533494A CA2533494A1 (fr) 2003-07-24 2004-07-22 Produits aryl-heteroaromatiques, compositions les contenant et utilisation
JP2006520863A JP2006528615A (ja) 2003-07-24 2004-07-22 アリールヘテロ芳香族生成物、それを含む組成物及びその使用
BRPI0412254-2A BRPI0412254A (pt) 2003-07-24 2004-07-22 produtos aril-heteroaromáticos, composições que os contêm e utilização
IL173205A IL173205A0 (en) 2003-07-24 2006-01-17 Aryl heteroaromatic products, compositions comprising the same and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0309092 2003-07-24
FR0309092A FR2857966A1 (fr) 2003-07-24 2003-07-24 Produits aryl-heteroaromatiques, compositions les contenant et utilisation

Publications (2)

Publication Number Publication Date
WO2005009947A2 WO2005009947A2 (fr) 2005-02-03
WO2005009947A3 true WO2005009947A3 (fr) 2005-03-31

Family

ID=33561081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/001944 WO2005009947A2 (fr) 2003-07-24 2004-07-22 Produits aryl-heteroaromatiques, compositions les contenant et utilisation

Country Status (14)

Country Link
US (1) US20050020593A1 (fr)
EP (1) EP1651602A2 (fr)
JP (1) JP2006528615A (fr)
KR (1) KR20060041274A (fr)
CN (1) CN1826319A (fr)
AR (1) AR045083A1 (fr)
AU (1) AU2004259112A1 (fr)
BR (1) BRPI0412254A (fr)
CA (1) CA2533494A1 (fr)
FR (1) FR2857966A1 (fr)
IL (1) IL173205A0 (fr)
MX (1) MXPA06000479A (fr)
TW (1) TW200524907A (fr)
WO (1) WO2005009947A2 (fr)

Families Citing this family (40)

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US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
AR051095A1 (es) * 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso comoinhibidores de la estearoil-coa desaturasa
TW200626155A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101083986A (zh) * 2004-09-20 2007-12-05 泽农医药公司 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途
BRPI0515478A (pt) * 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase
AU2005329423A1 (en) * 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
TW200626154A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101083982A (zh) 2004-09-20 2007-12-05 泽农医药公司 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物
CN101084207A (zh) * 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
WO2006034279A1 (fr) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation comme agents therapeutiques
EA013525B1 (ru) * 2005-05-20 2010-06-30 Алантос-Фармасьютикалз Холдинг, Инк. Гетеробициклические ингибиторы металлопротеазы и их применение
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
BRPI0611187A2 (pt) * 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
CN101268048A (zh) * 2005-09-16 2008-09-17 瑟瑞耐克斯有限公司 咔唑衍生物
CA2648748A1 (fr) * 2006-04-14 2007-10-25 Takeda Pharmaceutical Company Limited Compose heterocyclique azote
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
CN100444842C (zh) * 2006-11-30 2008-12-24 四川大学华西医院 N-芳基杂环族化合物的制药用途
SG183699A1 (en) * 2007-08-10 2012-09-27 Lundbeck & Co As H Heteroaryl amide analogues
EP2085398A1 (fr) 2008-02-01 2009-08-05 Merz Pharma GmbH & Co. KGaA Pyrazolopyrimidines, leur procédé de préparation et leur utilisation en tant que médicament
EP2090576A1 (fr) 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-pyrazolo[1,5-a]pyridines, leur procédé de préparation et leur utilisation en tant que modulateurs des récepteurs metabotropiques du glutamate (mGluR)
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
WO2012173952A1 (fr) 2011-06-13 2012-12-20 Emory University Dérivés de pipérazine, compositions et utilisations
PE20151332A1 (es) 2013-02-19 2015-09-20 Pfizer Compuestos de azabencimidazol
SG11201509650YA (en) * 2013-05-24 2015-12-30 Iomet Pharma Ltd Slc2a transporter inhibitors
PE20161372A1 (es) 2014-02-03 2017-01-08 Vitae Pharmaceuticals Inc Inhibidores de dihidropirrolopiridina de ror-gamma
EP2966856B1 (fr) * 2014-07-08 2020-04-15 Sony Depthsensing Solutions N.V. Pixel à plage dynamique élevée et son procédé de fonctionnement
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
KR102061952B1 (ko) 2014-08-06 2020-01-02 화이자 인코포레이티드 이미다조피리다진 화합물
UA118989C2 (uk) 2014-10-14 2019-04-10 Вітае Фармасьютікалс, Інк. Дигідропіролопіридинові інгібітори ror-гамма
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
CN104876851A (zh) * 2015-05-15 2015-09-02 南京大学 一类含吲哚-3羧酸骨架的哌嗪类衍生物的制备方法及在抗癌药物中的应用
EP3331876B1 (fr) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulateurs de ror-gamma
MA53943A (fr) 2015-11-20 2021-08-25 Vitae Pharmaceuticals Llc Modulateurs de ror-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
RS65129B1 (sr) 2016-03-28 2024-02-29 Incyte Corp Jedinjenja pirolotriazina kao inhibitori tam
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
CN111225914B (zh) 2017-07-24 2022-10-11 生命医药有限责任公司 RORγ的抑制剂
WO2019018975A1 (fr) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibiteurs de ror gamma
CA3107548A1 (fr) 2018-08-06 2020-02-13 Moexa Pharmaceuticals Limited Inhibiteurs de smad3

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WO2002060872A1 (fr) * 2001-02-01 2002-08-08 The Australian National University Synthese destinee a la preparation de composes de criblage utilises comme agents de fixation a la tubuline
WO2003037862A1 (fr) * 2001-10-30 2003-05-08 Nippon Shinyaku Co., Ltd. Derives amide, et medicaments correspondants
WO2003037861A1 (fr) * 2001-10-26 2003-05-08 Baxter Healthcare Sa Utilisation de 2-acylindoles pour traiter des tumeurs

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2002060872A1 (fr) * 2001-02-01 2002-08-08 The Australian National University Synthese destinee a la preparation de composes de criblage utilises comme agents de fixation a la tubuline
WO2003037861A1 (fr) * 2001-10-26 2003-05-08 Baxter Healthcare Sa Utilisation de 2-acylindoles pour traiter des tumeurs
WO2003037862A1 (fr) * 2001-10-30 2003-05-08 Nippon Shinyaku Co., Ltd. Derives amide, et medicaments correspondants

Also Published As

Publication number Publication date
MXPA06000479A (es) 2006-04-05
TW200524907A (en) 2005-08-01
EP1651602A2 (fr) 2006-05-03
CN1826319A (zh) 2006-08-30
AU2004259112A1 (en) 2005-02-03
KR20060041274A (ko) 2006-05-11
CA2533494A1 (fr) 2005-02-03
AR045083A1 (es) 2005-10-12
FR2857966A1 (fr) 2005-01-28
IL173205A0 (en) 2006-06-11
WO2005009947A2 (fr) 2005-02-03
JP2006528615A (ja) 2006-12-21
US20050020593A1 (en) 2005-01-27
BRPI0412254A (pt) 2006-09-19

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