Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
  • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
  • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
  • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
  • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
  • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
  • C07C2601/14—The ring being saturated
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
  • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Definitions

• the present relation relates to a process for regio- and stereoselective opening of an epoxide ring, and more particularly to the regio- and stereoselective conversion of (+)- limonene oxide to (+)-p-mentha-2,8-diene-l-ol.
• Epoxides also known as oxiranes, are useful intermediates in synthesizing active pharmaceutical ingredients and drugs.
• the inherent polarity and strain of the three- membered ring makes them susceptible to reaction with a large number of reagents.
• Of particular interest is the stereoselective nucleophilic attack of the epoxide ring to form
• THC Tetrahydrocannabinol
• Pha ⁇ naceutical interest in THC has increased due to FDA approval for several therapeutic applications.
• Many of the known processes for the preparation of THC utilize (+)-p-mentha-2,8-diene-l-ol or an analog thereof as an intermediate.
• the (+)-p-mentha- 2,8-diene-l-ol or an analog can be prepared from limonene through a synthesis that includes opening an epoxy ring.
• Conventional methods for converting limonene into (+)- p-mentha-2,8-diene-l-ol include oxidizing limonene with singlet oxygen and conversion using an enzymatic reaction.
• An aspect of the present invention is to provide a process for the regio- and stereoselective opening of an epoxide ring, the process comprising reacting a compound having the epoxide ring with at least one amine in the presence of at least one Lewis acid.
• Another aspect of the present invention is to provide a process for preparing (+)-p- mentha-2,8-diene-l-ol and analogs thereof.
• the process comprises reacting (+)-limonene oxide with an amine in the presence of a Lewis acid to form amine adduct intermediates.
• the desired amine adduct intermediate is formed at a ratio of .greater than 20: 1 over other reaction products.
• the desired amine adduct is then oxidized to form an N-oxide that is pyrolized to form (+)-p-mentha-2,8-diene-l-ol.
• the amine adduct is converted to an acid salt and then base hydrolyzed to form (+)-p-mentha-2,8-diene-l-ol.
• epoxide ring where one carbon of the epoxide ring is more substituted.
• a compound having such an epoxide ring is reacted with an amine in the presence of a Lewis acid.
• nucleophilic attack This allows for the regio- and stereoselective opening of the epoxide ring.
• step a (major) (minor)
• step b step c
• R 4 is an alkyl, alkenyl or alcohol.
• step a (major) (minor)
• Reaction step (a) comprises reacting a mixture of cis and trans isomers of (+)-
• the amine may be primary, wherein R 2 and R 3 are H; secondary, wherein R
• R ls R 2 and R 3 in the tertiary amine are limited only in that R lt R 2 and R 3 must
• Suitable amines include, but are not limited to, amines wherein R 1; R and R 3 are
• lower alkyl radicals having from about 1 to about 6 carbons, or aryl groups.
• the Lewis acid may be any compound containing an element that is two electrons
• acids include but are not limited to non-protic acids including metals, primarily halides,
• alkyls and ether complexes thereof.
• Suitable alkyl metal halides include MRX wherein
• R is an alkyl, preferably having 1 to 6 carbons.
• M is a metal, including but not limited to
• Suitable ether complexes include those of the formula MOR, wherein M is a metal and R is an alkyl, preferably having 1 to 6 carbons. While
• the metal is typically selected from Group I alkali metals, any suitable metal may be any suitable metal.
• M is selected from Li, K and Na,
• R is selected from methyl, ethyl, propyl or butyl.
• reaction products of step (a) are the amine adducts Formula (2b) and Formula
• Step (a) leads to a significant improvement of the regio- and stereoselectivity of the
• (+)-limonene oxide reaction of (+)-limonene oxide with the primary or secondary amine. Only one major
• Formula (2b) is formed at a ratio of
• Another advantage of the present invention is that the (+)-trans-limonene oxide
• Suitable acids include but are not limited to HCl salt using concentrated hydrochloric acid
• step (b) the amine adduct of Formula (2b) is oxidized to form the N-oxide of
• a peracid for example about 30% to about 50% hydrogen peroxide (H 2 O ) in the
• Suitable alcohols include but are not limited to alkyl
• step (c) the N-oxide intermediate Formula (4b) is pyrolized to produce (+)-p- mentha-2,8-diene-l-ol.
• This pyrolysis reaction to eliminate the tertiary amine oxide is known as a Cope elimination.
• the pyrolysis takes place in a
• solvent system including toluene at a temperature of at least about 110° C, or at any
• the pyrolysis takes place in toluene in the presence of at least one particulate matter such as zeolites or silica gels.
• the particulate matter is SiO 2 or molecular sieves.
• the overall yield of the conversion of (+)-limonene oxide to (+)-p-mentha-2,8- diene-1-ol of the present invention is typically about 50%.
• R t and R 2 are H, alkyl or aryl
• R5 is an H, aryl or alkyl; wherein R 4 is an alkyl, alkenyl or alcohol; and wherein X is a halide.
• the amine adduct of Formula (2b) reacts with the R 5 X to form the quaternary salt of Formula (6b) that is then heated under basic condition to form (+)-p-mentha-2,8-diene- l-ol of Formula (5b).
• Mel is used, as illustrated below.
• (+)-limonene oxide 40.00 g (0.26 mol) was dissolved into 90 ml of ethanol and placed into a 250 ml 3 neck round bottom flask.
• the ethanol was distilled off from the reaction mixture under vacuum to give a light yellow oil.
• the oil was then re-dissolved into 200 ml of chloroform, and the resulting solution was washed with 100 ml of deionized water twice and 100 ml of brine once, and finally dried with anhydrous MgSO 4 .
• the solid was filtered out and the solvent removed under vacuum to give a light yellow oil.
• the reaction product was analyzed by HPLC and compared to an authentic sample. The results indicated that the reaction product contained the major product II and a minor amount of m.
• Example 2 substituting lithium bromide in place of the lithium acetate in the reaction.
• reaction mixture was continuously stirred at 50° C for about 16 hours.
• (lS,2S,4R)-2-(N-diisopropyl)-l-methyl-4-(l-methylethenyl)-cyclohexanol was synthesized as described in example 5, by utilizing diisopropylamine as the amine.
• the product, (lS,2S,4R)-2-(N-diisopropyl)-l-methyl-4-(lmethylethenyl)- cyclohexanol was further purified and isolated by recrystallization in isopropanol.
• reaction mixture was heated to reflux for about 6 hours and followed by HPLC. Upon completion of the reaction the reaction mixture was filtered and the solvent
• the above compound was recovered as a colorless oil by fractional distillation.

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• Chemical & Material Sciences (AREA)
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• Chemical Kinetics & Catalysis (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

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• 2004
  • 2004-04-14 CA CA2523419A patent/CA2523419C/en not_active Expired - Fee Related
  • 2004-04-14 AU AU2004234350A patent/AU2004234350A1/en not_active Abandoned
  • 2004-04-14 EP EP04760258A patent/EP1660421A2/en not_active Withdrawn
  • 2004-04-14 CN CNA2004800109761A patent/CN1777569A/zh active Pending
  • 2004-04-14 US US10/549,976 patent/US7323607B2/en not_active Expired - Lifetime
  • 2004-04-14 MX MXPA05011292A patent/MXPA05011292A/es active IP Right Grant
  • 2004-04-14 WO PCT/US2004/011509 patent/WO2004096740A2/en not_active Ceased
  • 2004-04-14 JP JP2006510032A patent/JP2006524247A/ja not_active Withdrawn

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