WO2004084865A1 - Formulations comprising an active ingredient and cocoa powder and use thereof - Google Patents
Formulations comprising an active ingredient and cocoa powder and use thereof Download PDFInfo
- Publication number
- WO2004084865A1 WO2004084865A1 PCT/IB2004/000860 IB2004000860W WO2004084865A1 WO 2004084865 A1 WO2004084865 A1 WO 2004084865A1 IB 2004000860 W IB2004000860 W IB 2004000860W WO 2004084865 A1 WO2004084865 A1 WO 2004084865A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation according
- oil
- apis
- chosen
- administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- This invention relates to novel orally administered pharmaceutical formulations of one or more active pharmaceutical ingredients (APIs), optionally comprising salts, 5 complexes, prodrugs and metabolites thereof, further comprising cocoa powder, to the use of one or more active pharmaceutical ingredients (APIs), optionally comprising salts, prodrugs and metabolites thereof, for the manufacturing of a medicament to be administered orally for achieving a pharmacological effect, and to methods of medical treatment of humans or animals by oral administration of one or more active pharma- 10 ceutical ingredients (APIs), optionally comprising salts, prodrugs and metabolites thereof.
- APIs active pharmaceutical ingredients
- APIs active pharmaceutical ingredients
- APIs active pharmaceutical ingredients
- the present invention provides an orally administered pharmaceutical formulation of one or more APIs, optionally comprising salts, complexes, prodrugs and metabo- lites thereof for achieving a pharmacological effect.
- the administration can be to a human being or to an animal.
- Rapid onset is herein meant that a therapeutic effect is achieved within a short period of time, preferably in less than 1 hour, more preferably in less than 30 minutes, following administration.
- the administration may be accomplished without the addition of liquid.
- Administration without added liquid is a big advantage in all those situations where e g clean water or other suitable liquid is not available, such as on travel.
- the administration is discreet being a big advantage e g at lectures and on the theatre.
- use of the present formulation, which should melt in the mouth rather than be swallowed is of a great advantage to all those persons having difficulties in swallowing a traditional tablet.
- a particularly useful dosage form of the present invention is thus a formulation that disintegrates or melts in the mouth without need for drinking water or other fluid.
- the formulation is a dosage form comprising a therapeutically effective amount of one or more APIs. It is preferred that the amount of the one or more APIs be lower than an amount causing significant side effects.
- An object of the invention is to provide novel orally administered pharmaceutical formulations of one or more APIs comprising cocoa powder.
- a second object of the invention is to provide methods for preparing said formulations.
- a t hird object of the invention is methods for using said formulations in therapy for medical treatment of a human or animal subject.
- Formulations according to the present invention should preferably melt in the oral cavity, whereby intraoral uptake of the one or more APIs is favorized.
- the invention is adapted for discreet self-administration.
- discreet self- administration herein is meant self-administration that does not draw attention to the existence of a need for therapy.
- the formulation provides for a rapid onset through essentially intraoral uptake of the one or more APIs; 2) The formulation does not require any added liquid at the time of administration;
- the formulation provides for discreet self-administration; 6) The formulation is easy to administer for persons having problems in swallowing;
- the formulation provides for increased bioavailability due to reduced first-pass metabolism
- the formulation may provide for an association of pleasure.
- Cocoa powder is defined as cocoa nib with some fat removed and ground into a powder. Cocoa nib is defined as cocoa beans with the shell removed. Cocoa butter is defined as fat expelled from the center (kernels or nib) of cocoa beans. Cocoa powder is prepared from roasted cocoa beans. It is a complex compound, which consists of starch, cocoa butter, amino acids, proteins, xanthines, amines, mono- and polysaccharides % phospholipids, flavonoids, pyrazines, etc.
- the object of the invention to provide such a formulation that disintegrates and/or melts in the oral cavity with or without the aid of salivary fluid or mechanical erosion, or a combination thereof after which the formulation may show adhesiveness towards the tissues in the oral cavity.
- buffering agents provides for a transient change in local pH of the saliva, which facilitates uptake in the oral cavity.
- cocoa powder acts as taste masker, filler and texturizer.
- a general embodiment of a formulation according to the present invention has a weight of around 200 - 1000 mg and has the following composition (w/w):
- a formulation weighing around 400 mg, is prepared having the following composition (w/w):
- Cocoa powder may be used in a non-alkalized form and in an alkalized form. Both are useful in the present formulations. Alkalized cocoa powder is preferred when a somewhat milder taste is desirable.
- a part of the hydrogenated soybean oil is melted.
- the solid components i e the API if solid (eletriptan hydrobromide is solid), cocoa powder, mannitol, maize starch, aspartame, acesulfame-K, titanium dioxide, sodium chloride and the flavoring agents if solid, are added and mixed.
- a reduction of particle size of the solid components is performed by milling in a roll-refiner. If the solid components have already got the required particle size, e g by milling before the mixing with the fatty components, roll refining is dispensed with.
- the mixture After treatment in the roll-refiner the mixture is mixed with the rest of the melted fatty components or remelted, if solidified, and mixed with the rest of t he melted hydrogenated soybean oil.
- a mixing of the melt is performed in a suitable mixer.
- the liquid components, i e the API if liquid (eletriptan hydrobromide is though solid and is handled as above), soy lecithin and the flavoring agents if liquid, are added. Tablets or other solid dosage forms are subsequently made using suitable techniques, such as molding, extrusion or congealing, including pastiUation, when necessary after suitable preconditioning. Also other suitable manufacturing methods may be used.
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 500 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 300 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 400 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 600 mg having the below ingredients (w/w):
- Example 6 Preparation of a further embodiment In essentially the same way as in Example 1 is manufactured a formulation ⁇ vith a weight of around 400 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 400 mg having the below ingredients (w/w):
- Example 8 Preparation of a further embodiment In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 400 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 400 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 400 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 300 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 300 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 800 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 500 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 600 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 is manufactured a formulation with a weight of around 500 mg having the below ingredients (w/w):
- Example 2 In essentially the same way as in Example 1 are manufactured formulations with a weight from around 200 mg to around 1000 mg having the below ingredients:
- APIs active pharmaceutical ingredients
- the above one or more active pharmaceutical ingredients is/are selected from APIs suitable for intraoral uptake, preferred, but non-limiting examples of which are o the antiinflammatory agents diclofenac, ketorolac, indometacin, tornoxicam, piroxicam, tenoxicam, ketoprofen, celecoxib and roficoxib; o the muscle relaxants orphenadrine and baclofen; o the drugs affecting bone mineralization alendronic acid and risedronic acid; o the analgesics propoxyphene, buprenorfin, ketobenidon, hydromorphone, tramadol and morphine o the antimigraine preparations dihydroergotamine, ergotamine, eletriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan; o the anti-Parkinson drags pramipexole, ropinirole and selegiline;
- cocoa powder may be used in its non-alkalized form, its alkalized form or in a mixture thereof.
- the diluents may be selected from one or more of the compounds sucrose, fructose, glucose, galactose, lactose, maltose, invert sugar, a pharmaceutically acceptable polyol such as xylitol, sorbitol, maltitol, mannitol, isomalt and glycerol, or polydex- trose, or starch, or any mixture thereof, but only to such an extent that the taste-masking effect of the cocoa-powder remains sufficient.
- a pharmaceutically acceptable polyol such as xylitol, sorbitol, maltitol, mannitol, isomalt and glycerol, or polydex- trose, or starch, or any mixture thereof, but only to such an extent that the taste-masking effect of the cocoa-powder remains sufficient.
- the lipid ingredient being fatty components, may be chosen from one or more of the following compounds: - cocoa butter and cocoa butter alternatives, including cocoa butter equivalents
- CBE cocoa butter substitutes
- CBR cocoa butter replacers
- CBI cocoa butter improvers
- the optional buffering agent s may be selected from one or more of carbonates, bicarbonates, acetates, gluconates, glycerophosphates, phosphates or glycinates of sodium, potassium or ammonium, or mixtures thereof. Most phosphates are though less suitable because their taste usually is disagreeable and difficult to mask. Addition of buffering agents/s may increase the uptake through the mucosa in the oral cavity.
- the sweetener may selected from one or more artificial sweeteners, such as sucrose, aspartame, acesulfame potassium saccharine, sodium saccharine, cyclamate, glycyrrhizine, thaumatin (talin), sucralose, dihydrochalcone (neohesperidin dihydro- chalcone), alitame, miraculin (miracle fruit), monellin (serendipity berry), stevside and/or salts thereof.
- artificial sweeteners such as sucrose, aspartame, acesulfame potassium saccharine, sodium saccharine, cyclamate, glycyrrhizine, thaumatin (talin), sucralose, dihydrochalcone (neohesperidin dihydro- chalcone), alitame, miraculin (miracle fruit), monellin (serendipity berry), stevside and/or salts thereof
- the emulsifier/solubiliser is preferably soy lecithin and/or egg lecithin, but may be exchanged for
- nonionic surfactant such as poloxamer, polyoxyethylene alkyl ether, polyoxyethylene castor oil derivative, polyoxyethylene sorbitan fatty acid ester, monoglyce- ride, diglyceride and esther thereof, polyoxyethylene stearate, polyglycerolester of fatty acids, including polyglycerolpolyricinoleic acid (PGPR), sorbitan fatty acid ester,
- PGPR polyglycerolpolyricinoleic acid
- an anionic surfactant such as fatty acid, soap of fatty acid, lactylate, especially sodium and/or calcium stearoyllactylate, sodium lauryl sulfate and latanol,
- zwitterionic surfactant such as zwitterionic phospholipid, such as phosphati- dylcholine and phosphatidylethanolamine, or mixtures, fractions or derivatives thereof or with lecithin.
- the taste modifier is preferably selected from sodium chloride, monosodium glutamate and ammonium glycyrrhizinate.
- the coloring agent is preferably selected from titanium dioxide, iron oxides and aluminum lakes.
- Formulations according to the present inventions primarily constitute meltable and/or suckable oral tablets, but also include other suitable dosage forms for intraoral administration such as buccal patches, buccal pastes and buccal sprays.
- the present invention encompasses administration of the captioned formulations via the oral route concomitantly with administration APIs via one or more other routes, such as through transdermal administration, peroral administration, administration by inhalation, administration by creams, salves and vagitories, and/or administration by injection.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002519155A CA2519155A1 (en) | 2003-03-26 | 2004-03-16 | Formulations comprising an active ingredient and cocoa powder and use thereof |
MXPA05010196A MXPA05010196A (es) | 2003-03-26 | 2004-03-16 | Nuevas formulaciones y su uso. |
BRPI0408655-4A BRPI0408655A (pt) | 2003-03-26 | 2004-03-16 | formulações compreendendo um agente ativo e cacau em pó e a sua utilização |
AU2004224557A AU2004224557B2 (en) | 2003-03-26 | 2004-03-16 | Formulations comprising an active ingredient and cocoa powder and use thereof |
EP04720946A EP1605921A1 (en) | 2003-03-26 | 2004-03-16 | Formulations comprising an active ingredient and cocoa powder and use thereof |
JP2006506377A JP2006521348A (ja) | 2003-03-26 | 2004-03-16 | 活性成分及びカカオ粉末を含む製剤、並びにその使用 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0300831-5 | 2003-03-26 | ||
SE0300831A SE0300831D0 (sv) | 2003-03-26 | 2003-03-26 | New formulations and use therof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004084865A1 true WO2004084865A1 (en) | 2004-10-07 |
Family
ID=20290786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2004/000860 WO2004084865A1 (en) | 2003-03-26 | 2004-03-16 | Formulations comprising an active ingredient and cocoa powder and use thereof |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1605921A1 (es) |
JP (2) | JP2006521348A (es) |
CN (1) | CN1764440A (es) |
AR (1) | AR043772A1 (es) |
AU (1) | AU2004224557B2 (es) |
BR (1) | BRPI0408655A (es) |
CA (1) | CA2519155A1 (es) |
CL (1) | CL2004000564A1 (es) |
MX (1) | MXPA05010196A (es) |
SE (1) | SE0300831D0 (es) |
TW (1) | TW200503782A (es) |
WO (1) | WO2004084865A1 (es) |
ZA (1) | ZA200507719B (es) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009502984A (ja) * | 2005-08-02 | 2009-01-29 | ドロサファーム アクチェンゲゼルシャフト | インドメタシン及び/又はアセメタシンを含む医薬組成物 |
US8263581B2 (en) | 2009-07-03 | 2012-09-11 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
US8513259B2 (en) | 2009-07-03 | 2013-08-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8900645B2 (en) | 2007-06-13 | 2014-12-02 | Otsuka Pharmaceuticals Co., Ltd. | Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food |
US8927025B2 (en) | 2010-05-11 | 2015-01-06 | Cima Labs Inc. | Alcohol-resistant metoprolol-containing extended-release oral dosage forms |
US8951555B1 (en) | 2000-10-30 | 2015-02-10 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US8975273B2 (en) | 1999-10-29 | 2015-03-10 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
WO2015189726A1 (en) * | 2014-06-10 | 2015-12-17 | Capsugel Belgium Nv | Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use |
US9974751B2 (en) | 2006-09-15 | 2018-05-22 | Cima Labs Inc. | Abuse resistant drug formulation |
US10166187B2 (en) | 2013-03-06 | 2019-01-01 | Capsugel Belgium Nv | Curcumin solid lipid particles and methods for their preparation and use |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
WO2019166098A1 (de) * | 2018-03-01 | 2019-09-06 | Lts Lohmann Therapie-Systeme Ag | Orale darreichungsform mit theobrominfreiem kakao |
US11324699B2 (en) | 2014-12-04 | 2022-05-10 | Capsugel Belgium Nv | Lipid multiparticulate formulations |
US11331268B2 (en) | 2016-11-18 | 2022-05-17 | The University Of Western Australia | Taste masking product |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101444273B (zh) * | 2007-11-22 | 2013-04-24 | 何煜 | 一种保健品口腔速释制剂及其制造方法 |
CN101439053A (zh) * | 2007-11-22 | 2009-05-27 | 何煜 | 一种中药口腔速释制剂及其制造方法 |
WO2009070978A1 (fr) * | 2007-11-22 | 2009-06-11 | Yu He | Libération rapide dans la cavité buccale des produits de santé et procédé de préparation associé |
BRPI1012170A2 (pt) * | 2009-05-20 | 2016-03-29 | Lingual Consegna Pty Ltd | formulação e/ou sublingual e método para reduzir a quantidade de composto ativo usado para alcançar um efeito em um paciente em comparação com um composto típico que é ingerido. |
CN103583781B (zh) * | 2013-11-01 | 2015-11-25 | 阳波 | 咖啡味甲硝唑口香糖 |
JP6334482B2 (ja) * | 2015-08-28 | 2018-05-30 | 中野Bc株式会社 | 固形剤とその製造方法 |
CN108430233A (zh) * | 2015-12-09 | 2018-08-21 | 波维瓦茶业有限责任公司 | 包含亲脂性活性剂的稳定的即饮型饮料组合物 |
CA3176596A1 (en) * | 2015-12-09 | 2017-06-15 | Poviva Corp. | Methods for formulating orally ingestible compositions comprising lipophilic active agents |
CN109053718B (zh) * | 2018-08-09 | 2022-06-03 | 天津理工大学 | 一种罗格列酮糖精盐及其制备方法 |
CN111729087A (zh) * | 2020-07-24 | 2020-10-02 | 成都大学 | 一种选择性β2受体激动剂的脂质修饰物及其制备方法与用途 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB785574A (en) * | 1955-03-29 | 1957-10-30 | Pfizer & Co C | Pharmaceutical compositions containing tetracycline antibiotics |
GB918955A (en) * | 1960-05-19 | 1963-02-20 | Thomae Gmbh Dr K | Pharmaceutical laxative compositions comprising 4,4-dihydroxy-2-amino triphenylmethane |
FR2717387A1 (fr) * | 1994-03-17 | 1995-09-22 | Hi Pharmtech | Procédé de fabrication de comprimés à croquer à base de troxérutine, de carbonate de calcium, de phosphate de calcium, d'aspartate d'arginine, de glutamate d'arginine d'amoxicilline. |
WO2000030641A1 (en) * | 1998-11-23 | 2000-06-02 | Pharmacia & Upjohn Ab | Nicotine-containing pharmaceutical compositions giving a rapid transmucosal absorption |
JP2001114668A (ja) * | 1999-10-13 | 2001-04-24 | Meiji Seika Kaisha Ltd | チョコレート剤 |
JP2002193839A (ja) * | 2000-12-27 | 2002-07-10 | Meiji Seika Kaisha Ltd | ココア製剤 |
WO2003026655A1 (en) * | 2001-09-27 | 2003-04-03 | Pharmacia Ab | New formulations and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001106641A (ja) * | 1999-10-06 | 2001-04-17 | Tendou Seiyaku Kk | 口内薬 |
US20020172732A1 (en) * | 2001-03-21 | 2002-11-21 | Wies Ter Laak | Composition comprising cocoa |
-
2003
- 2003-03-26 SE SE0300831A patent/SE0300831D0/xx unknown
-
2004
- 2004-03-16 MX MXPA05010196A patent/MXPA05010196A/es unknown
- 2004-03-16 AU AU2004224557A patent/AU2004224557B2/en not_active Ceased
- 2004-03-16 CN CNA2004800077898A patent/CN1764440A/zh active Pending
- 2004-03-16 BR BRPI0408655-4A patent/BRPI0408655A/pt not_active IP Right Cessation
- 2004-03-16 CA CA002519155A patent/CA2519155A1/en not_active Abandoned
- 2004-03-16 JP JP2006506377A patent/JP2006521348A/ja not_active Withdrawn
- 2004-03-16 WO PCT/IB2004/000860 patent/WO2004084865A1/en active Application Filing
- 2004-03-16 EP EP04720946A patent/EP1605921A1/en not_active Withdrawn
- 2004-03-18 CL CL200400564A patent/CL2004000564A1/es unknown
- 2004-03-23 TW TW093107802A patent/TW200503782A/zh unknown
- 2004-03-24 AR ARP040100981A patent/AR043772A1/es not_active Application Discontinuation
-
2005
- 2005-09-23 ZA ZA200507719A patent/ZA200507719B/en unknown
-
2010
- 2010-11-15 JP JP2010255113A patent/JP2011079841A/ja active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB785574A (en) * | 1955-03-29 | 1957-10-30 | Pfizer & Co C | Pharmaceutical compositions containing tetracycline antibiotics |
GB918955A (en) * | 1960-05-19 | 1963-02-20 | Thomae Gmbh Dr K | Pharmaceutical laxative compositions comprising 4,4-dihydroxy-2-amino triphenylmethane |
FR2717387A1 (fr) * | 1994-03-17 | 1995-09-22 | Hi Pharmtech | Procédé de fabrication de comprimés à croquer à base de troxérutine, de carbonate de calcium, de phosphate de calcium, d'aspartate d'arginine, de glutamate d'arginine d'amoxicilline. |
WO2000030641A1 (en) * | 1998-11-23 | 2000-06-02 | Pharmacia & Upjohn Ab | Nicotine-containing pharmaceutical compositions giving a rapid transmucosal absorption |
JP2001114668A (ja) * | 1999-10-13 | 2001-04-24 | Meiji Seika Kaisha Ltd | チョコレート剤 |
JP2002193839A (ja) * | 2000-12-27 | 2002-07-10 | Meiji Seika Kaisha Ltd | ココア製剤 |
WO2003026655A1 (en) * | 2001-09-27 | 2003-04-03 | Pharmacia Ab | New formulations and use thereof |
Non-Patent Citations (3)
Title |
---|
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 10 July 2002 (2002-07-10), ISHIKURA, TOYOAKI ET AL: "Cocoa powder-containing pharmaceutical formulations", XP002289559, retrieved from STN Database accession no. 2002:513067 * |
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 April 2001 (2001-04-25), ISHIKURA, TOYOAKI ET AL: "Pharmaceutical chocolate preparations using cocoa butter substitutes", XP002289558, retrieved from STN Database accession no. 2001:290825 * |
See also references of EP1605921A1 * |
Cited By (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9675611B1 (en) | 1999-10-29 | 2017-06-13 | Purdue Pharma L.P. | Methods of providing analgesia |
US9320717B2 (en) | 1999-10-29 | 2016-04-26 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US10076516B2 (en) | 1999-10-29 | 2018-09-18 | Purdue Pharma L.P. | Methods of manufacturing oral dosage forms |
US9669022B2 (en) | 1999-10-29 | 2017-06-06 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9669024B2 (en) | 1999-10-29 | 2017-06-06 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9278074B2 (en) | 1999-10-29 | 2016-03-08 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9056107B1 (en) | 1999-10-29 | 2015-06-16 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US8975273B2 (en) | 1999-10-29 | 2015-03-10 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US8980291B2 (en) | 1999-10-29 | 2015-03-17 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9682077B2 (en) | 2000-10-30 | 2017-06-20 | Purdue Pharma L.P. | Methods of providing analgesia |
US9526724B2 (en) | 2000-10-30 | 2016-12-27 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9056052B1 (en) | 2000-10-30 | 2015-06-16 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US8951555B1 (en) | 2000-10-30 | 2015-02-10 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9060940B2 (en) | 2000-10-30 | 2015-06-23 | Purdue Pharma L.P. | Controlled release hydrocodone |
US10022368B2 (en) | 2000-10-30 | 2018-07-17 | Purdue Pharma L.P. | Methods of manufacturing oral formulations |
US9669023B2 (en) | 2000-10-30 | 2017-06-06 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9572804B2 (en) | 2000-10-30 | 2017-02-21 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9572805B2 (en) | 2000-10-30 | 2017-02-21 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9198863B2 (en) | 2000-10-30 | 2015-12-01 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9289391B2 (en) | 2000-10-30 | 2016-03-22 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9205055B2 (en) | 2000-10-30 | 2015-12-08 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9517236B2 (en) | 2000-10-30 | 2016-12-13 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9504681B2 (en) | 2000-10-30 | 2016-11-29 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9205056B2 (en) | 2000-10-30 | 2015-12-08 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US9023401B1 (en) | 2000-10-30 | 2015-05-05 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
JP2009502984A (ja) * | 2005-08-02 | 2009-01-29 | ドロサファーム アクチェンゲゼルシャフト | インドメタシン及び/又はアセメタシンを含む医薬組成物 |
US9216176B2 (en) | 2006-09-15 | 2015-12-22 | Cima Labs Inc. | Abuse resistant drug formulation |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
US9572803B2 (en) | 2006-09-15 | 2017-02-21 | Cima Labs Inc. | Abuse resistant drug formulation |
US9974751B2 (en) | 2006-09-15 | 2018-05-22 | Cima Labs Inc. | Abuse resistant drug formulation |
US10681930B2 (en) | 2007-06-13 | 2020-06-16 | Otsuka Pharmaceutical Co., Ltd. | Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food |
US8993014B2 (en) | 2007-06-13 | 2015-03-31 | Otsuka Pharmaceutical Co., Ltd. | Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food |
US9192185B2 (en) | 2007-06-13 | 2015-11-24 | Otsuka Pharmaceutical Co., Ltd. | Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food |
US8900645B2 (en) | 2007-06-13 | 2014-12-02 | Otsuka Pharmaceuticals Co., Ltd. | Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food |
US9180090B2 (en) | 2009-07-03 | 2015-11-10 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8314083B2 (en) | 2009-07-03 | 2012-11-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8263581B2 (en) | 2009-07-03 | 2012-09-11 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US9161902B2 (en) | 2009-07-03 | 2015-10-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US9119771B2 (en) | 2009-07-03 | 2015-09-01 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8513259B2 (en) | 2009-07-03 | 2013-08-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
US8927025B2 (en) | 2010-05-11 | 2015-01-06 | Cima Labs Inc. | Alcohol-resistant metoprolol-containing extended-release oral dosage forms |
US10166187B2 (en) | 2013-03-06 | 2019-01-01 | Capsugel Belgium Nv | Curcumin solid lipid particles and methods for their preparation and use |
WO2015189726A1 (en) * | 2014-06-10 | 2015-12-17 | Capsugel Belgium Nv | Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use |
EP3766480A1 (en) * | 2014-06-10 | 2021-01-20 | Capsugel Belgium NV | Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use |
US11324699B2 (en) | 2014-12-04 | 2022-05-10 | Capsugel Belgium Nv | Lipid multiparticulate formulations |
US11331268B2 (en) | 2016-11-18 | 2022-05-17 | The University Of Western Australia | Taste masking product |
WO2019166098A1 (de) * | 2018-03-01 | 2019-09-06 | Lts Lohmann Therapie-Systeme Ag | Orale darreichungsform mit theobrominfreiem kakao |
US20210000963A1 (en) * | 2018-03-01 | 2021-01-07 | Lts Lohmann Therapie-Systeme Ag | Oral dosage form containing theobromine-free cocoa |
Also Published As
Publication number | Publication date |
---|---|
JP2006521348A (ja) | 2006-09-21 |
ZA200507719B (en) | 2007-09-26 |
SE0300831D0 (sv) | 2003-03-26 |
AU2004224557A1 (en) | 2004-10-07 |
CL2004000564A1 (es) | 2005-02-04 |
EP1605921A1 (en) | 2005-12-21 |
AR043772A1 (es) | 2005-08-10 |
CN1764440A (zh) | 2006-04-26 |
MXPA05010196A (es) | 2005-11-08 |
AU2004224557B2 (en) | 2009-06-18 |
BRPI0408655A (pt) | 2006-03-28 |
TW200503782A (en) | 2005-02-01 |
CA2519155A1 (en) | 2004-10-07 |
JP2011079841A (ja) | 2011-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2004224557B2 (en) | Formulations comprising an active ingredient and cocoa powder and use thereof | |
AU2002334522B2 (en) | New formulations and use thereof | |
US20100197742A1 (en) | New formulations and use thereof | |
JP2002530335A (ja) | 急速経粘膜吸収を与えるニコチン含有医薬組成物 | |
AU2002334522A1 (en) | New formulations and use thereof | |
US20070092554A1 (en) | Sexual Dysfunction Compounds | |
CN1674866B (zh) | 含有治疗性功能障碍化合物和可可粉的药物制剂及其用途 | |
CN100548281C (zh) | 用于递送催眠药穿过口腔粘膜的组合物及其用法 | |
ZA200506710B (en) | Formulations comprising tolterodine and cocoa powder and use thereof | |
US20040191345A1 (en) | New formulations and use thereof | |
KR20050047527A (ko) | 코코아 분말을 포함하는, 신속하게 발현되는 신규성적-기능장애-화합물-함유 제약 제제 및 그의 용도 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2004224557 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004720946 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 3884/DELNP/2005 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2519155 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2004224557 Country of ref document: AU Date of ref document: 20040316 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2004224557 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20048077898 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005/07719 Country of ref document: ZA Ref document number: PA/a/2005/010196 Country of ref document: MX Ref document number: 200507719 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006506377 Country of ref document: JP |
|
WWP | Wipo information: published in national office |
Ref document number: 2004720946 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0408655 Country of ref document: BR |