WO2004067017A1 - Brouillard de feng-you-jing - Google Patents

Brouillard de feng-you-jing Download PDF

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Publication number
WO2004067017A1
WO2004067017A1 PCT/CN2003/001089 CN0301089W WO2004067017A1 WO 2004067017 A1 WO2004067017 A1 WO 2004067017A1 CN 0301089 W CN0301089 W CN 0301089W WO 2004067017 A1 WO2004067017 A1 WO 2004067017A1
Authority
WO
WIPO (PCT)
Prior art keywords
spray
bottle
pharmaceutical composition
camphor
wind
Prior art date
Application number
PCT/CN2003/001089
Other languages
English (en)
Chinese (zh)
Inventor
Chengfei Zhang
Huihong Zhang
Original Assignee
Beijing Orientking Pharmaceutical Science & Technology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Orientking Pharmaceutical Science & Technology Co., Ltd. filed Critical Beijing Orientking Pharmaceutical Science & Technology Co., Ltd.
Priority to AU2003292859A priority Critical patent/AU2003292859A1/en
Publication of WO2004067017A1 publication Critical patent/WO2004067017A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the invention relates to a medicinal preparation, in particular to a prescription, a preparation process and a spray device of wind olein spray.
  • Fengyoujing is an over-the-counter medicine for traditional Chinese medicine. It is an indispensable medicine for people traveling at home. Especially in summer, Fengyoujing is popular for its good mosquito repellent and anti-inflammatory, analgesic, cool, antipruritic and wind-repellent effects. .
  • liquid wind olein only has one formulation of tincture, and a single formulation brings many inconveniences to people. For example: When people use wind olein as a mosquito repellent in summer, they usually apply wind olein on the body. It is impossible to apply the whole body evenly. Only some parts can be selected. The part is irritating, and the part that is not applied is still vulnerable to mosquito attack.
  • the invention uses wind oil essence to make a spray, which has the following advantages: 1) When used to repel mosquitoes on human bodies and objects, it can be distributed evenly by spraying a few times easily, and achieves a good mosquito repellent effect. 2) The insect repellent can be sprayed directly into the air, and the insect repellent can be sprayed out of the hand. 3) As oral spray can be used with a fixed-dose manual pump, as long as it is sprayed into the cup according to the dosage, it can be taken by adding water, the dosage is accurate. 4) The solvent used has a wide range of sources and is cheap, and the preparation process used is simple and suitable for industrial production.
  • the invention is composed of a medicinal solution prepared from the main medicine and auxiliary materials of wind olein and a spray device.
  • wind olein refers to the wind olein contained in the ministerial standard.
  • the weight ratio of the main drug is 10-40% menthol, 5-35% methyl salicylate, and camphor 0. 5-5%, eucalyptus oil 0.5-5%, eugenol 0.5-5%, and excipients 5-80%.
  • the excipients include an additive and a pharmaceutically acceptable solvent
  • the additive includes a flavoring agent such as a flavor, a weight ratio of 1-20%, and a coloring agent such as chlorophyll, a weight ratio of 0.01-1%, a pharmaceutically acceptable solvent weight The ratio is 3-70%.
  • the preferred prescription composition of the main medicine is 320 g of menthol, 260 g of methyl salicylate, 30 g of camphor, 30 g of eucalyptus oil, 30 g of eugenol, 100 g of essence, lg of chlorophyll, and the solvent is added to 1000 g.
  • the term "> aerosol” refers to a formulation containing no propellant and releasing the contents in the form of a mist or the like by the pressure of a hand pump.
  • the spray device used in the present invention is composed of a manual pump (also called a valve system) and a bottle body.
  • the valve system may adopt a quantitative valve system or a non-quantitative valve system, preferably a quantitative Gangmen system, such as the quantitative of the German Pfeiffer company (Pfeiffer).
  • Spray pump The basic composition of the valve system is the basic pump, screw cap, immersion tube, gasket, push button, spray head, integrated atomizer and protective cover. Among them, the immersion tube may not be used, but the spray bottle needs to be inverted when using. 05- 0. 20ml ⁇ Each spray dose of the spray bottle is 0. 02- 0. 3ml, preferably 0. 05-0. 20ml.
  • the bottle used in the present invention is a glass bottle.
  • Plastic spray bottles are usually used for medicinal use. However, during the implementation of the present invention, it was unexpectedly discovered that wind oil essence liquid will be lost after long-term storage in plastic bottles. There is no loss (see the experimental research section), which may be due to the certain volatility of wind oil and the certain permeability of plastic bottles.
  • the medicinal solution of the present invention is composed of the main drug of wind olein, an additive and a solvent.
  • Viscosity is an important factor affecting spray performance (see Table 1, provided by Taiwan System Spray Co., Ltd.). Increasing viscosity increases the shape of the spray and the size of the droplets becomes larger. Generally, the viscosity of the solution When the degree exceeds a certain range, it cannot be atomized.
  • the patent CN1346298 proves that the fragrance with a viscosity of more than 6.4 centipoise cannot be atomized in its device through an example.
  • the present invention proves that when a manual pump is used, the viscosity is above 55 centipoise. It cannot be atomized.
  • the present invention surprisingly found that: the main drug of wind olein can increase the viscosity of low-viscosity solvents, while for high-viscosity solvents, wind olein
  • the main drug can greatly reduce its viscosity (see the experimental research section), a result that cannot be taught by the prior art.
  • high-viscosity solvents such as polyethylene glycol 400, propylene glycol, liquid paraffin, fatty oils, etc.
  • the solvent itself is laborious to spray (spraying labor makes it difficult for people to use) or cannot be sprayed. Can form a good spray.
  • the solvent used in the present invention is selected from one or a mixture of liquid paraffin, ethanol, propylene glycol, ethyl acetate, glycerin, isopropyl myristate, polyethylene glycol, and fatty oils, and preferably liquid Body paraffin, absolute ethanol, polyethylene glycol, isopropyl myristate, and most preferably liquid paraffin.
  • the viscosity of the drug solution prepared by using the solvent in the present invention is 55 centipoise or less, preferably 27 centipoise or less.
  • the preparation process of the present invention is: take menthol and camphor, add an appropriate amount of solvent, and then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add solvent, mix well, leave it for 24 hours, and take a clear solution , Dispensed in a glass spray bottle, tighten the hand pump, that's it.
  • Viscosity is the property of a liquid and is the resistance of a liquid to changes in the shape or arrangement of its constituents during flow. Liquid viscosity is the main factor that affects the formation of spray shapes, and it is also an important factor that determines the size of droplets. As the viscosity of liquid increases, the particle size of droplets increases. High viscosity liquids require higher lower pressures to form a spray shape and produce a narrow spray angle. For this type of wind oil essence spray sprayed by hand pump, the spray pressure is constant, and the solution with a viscosity exceeding a certain limit may not be able to form a spray, and the solution forming the spray may not have a suitable spray shape and droplets. Size, it is necessary to conduct a viscosity study on the drug solution to find a drug solution with a suitable viscosity for spraying.
  • Preparation process Take menthol and camphor, add an appropriate amount of ethanol, and then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add ethanol to 1000g, mix well, leave it for 24 hours, take the clear solution, Dispensed in a glass spray bottle and screwed on the hand pump.
  • the spray has a solid cone shape. In the area covered, the droplets are uniformly distributed, round, and the droplets are small.
  • Preparation process Take menthol and camphor, add an appropriate amount of liquid paraffin, and then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add liquid stone field to make 1000g, mix well, let stand for 24 hours, and clarify The liquid is dispensed into a glass spray bottle, and the hand pump is tightened, and the liquid is obtained.
  • the spray has a solid cone shape. In the area covered, the droplets are distributed uniformly, in a garden shape, and the droplets are small.
  • Preparation process Take menthol and camphor, add an appropriate amount of ethyl acetate, and then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add ethyl acetate to make 1000g, mix well, and let stand for 24 hours. Take the clear solution, dispense it into a glass spray bottle, and tighten the hand pump to get it.
  • the spray has a solid shape. In the area covered, the droplets are uniformly distributed, round, and the droplets are small.
  • Preparation process Take menthol and camphor, add an appropriate amount of isopropyl myristate, and then add eucalyptus oil, methyl salicylate, eucalyptus butanol, flavor, and chlorophyll, and add myristic acid iso-green oil.
  • the propyl ester was made into 1000g, mixed with the hook, and left to stand for 24 hours.
  • the clear solution was taken and dispensed into a glass spray bottle, and the hand pump was tightened to obtain it.
  • the spray has a solid cone shape. In the area covered, the droplets are uniformly distributed, round, and the droplets are small.
  • Preparation process Take menthol and camphor, add an appropriate amount of propylene glycol, and then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add propylene glycol to 1000g, mix well, leave it for 24 hours, and take a clear solution. Dispensed in a glass spray bottle and screwed on the hand pump.
  • Preparation process Take menthol and camphor, add an appropriate amount of polyethylene glycol 400, and then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add polyethylene glycol 400 to 1000 g, mix well, and mix Set for 24 hours, take the clear solution, dispense it into a glass spray bottle, and tighten the hand pump to get it.
  • the spray has a solid cone and a slightly larger spray angle. In the area covered, the droplets are uniformly distributed, round, and the droplets are small.
  • Preparation process Take menthol and camphor, add an appropriate amount of mixed solvent, then add eucalyptus oil, methyl salicylate, eugenol, flavor, and appropriate amount of chlorophyll, add mixed solvent to make 1000g, mix well, let stand for 24 hours, and clarify The liquid is dispensed into a glass spray bottle, and the hand pump is tightened to obtain it.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un FENG-YOU-JING sous forme de brouillard, qui consiste en un médicament liquide et un dispositif pulvérisateur. Ledit médicament liquide, dont le composant principal et le FENG-YOU-JING, et qui contient un additif et un solvant médicinal, se compose de méthol, de salicylate de méthyle, de camphre, d'huile d'eucalyptus, d'eugénole, d'additif et de solvant médicinal. Le dispositif pulvérisateur comporte une pompe manuelle et un flacon, lequel flacon est en verre.
PCT/CN2003/001089 2002-12-31 2003-12-19 Brouillard de feng-you-jing WO2004067017A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003292859A AU2003292859A1 (en) 2002-12-31 2003-12-19 Feng-you-jing spray

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN02159441A CN1424105A (zh) 2002-12-31 2002-12-31 风油精喷雾剂
CN02159441.4 2002-12-31

Publications (1)

Publication Number Publication Date
WO2004067017A1 true WO2004067017A1 (fr) 2004-08-12

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ID=4753305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2003/001089 WO2004067017A1 (fr) 2002-12-31 2003-12-19 Brouillard de feng-you-jing

Country Status (3)

Country Link
CN (1) CN1424105A (fr)
AU (1) AU2003292859A1 (fr)
WO (1) WO2004067017A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103223015A (zh) * 2013-05-03 2013-07-31 广东伊茗药业有限公司 一种治疗肌肉酸痛及皮肤痕痒的药物组合物及其制备方法
CN105770237B (zh) * 2016-04-22 2018-01-26 广东红珊瑚药业有限公司 一种具有止痒、消炎功效的泡沫剂及其制备方法
CN108014410A (zh) * 2016-10-31 2018-05-11 吉林化工学院 吸入振动式樟脑治疗仪
CN106474241A (zh) * 2016-12-07 2017-03-08 广西大学 一种含有叶绿素成分的制剂
CN107412343B (zh) * 2017-05-04 2020-09-22 湖南青木青生物科技有限公司 提神喷雾及其制备方法
CN107412210A (zh) * 2017-05-26 2017-12-01 何东良 一种治疗老年人的身体异味和/或口腔异味的药物组合物及其制剂
CN107232187A (zh) * 2017-06-23 2017-10-10 骆琦 一种百草植物驱蚊喷雾液及其制备方法
CN108117929B (zh) * 2017-12-21 2018-11-20 漳州水仙药业股份有限公司 一种精油及其制备方法
CN109106837A (zh) * 2018-04-19 2019-01-01 陕西谷佳现代有机农业科技有限公司 一种以生物质干馏提取物制成的喷剂
CN114848510A (zh) * 2022-06-26 2022-08-05 张忠明 一种长效驱蚊止痒喷雾及制备方法
CN116173098A (zh) * 2022-12-31 2023-05-30 河南农业大学 一种防暑驱蚊木本清凉油及其制备方法及使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1365686A (zh) * 2001-01-15 2002-08-28 杨孟君 纳米丁香制剂药物及其制备方法
CN1369302A (zh) * 2002-01-28 2002-09-18 赵子珍 固体风油精

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1365686A (zh) * 2001-01-15 2002-08-28 杨孟君 纳米丁香制剂药物及其制备方法
CN1369302A (zh) * 2002-01-28 2002-09-18 赵子珍 固体风油精

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Drug standard of Ministry of public health of the People's Republic of China---Ready-prepared chinese medicine preparation", ASSOCIATION OF PHARMACOPOEIA OF PEOPLE'S REPUBLIC OF CHINA, 31 December 1994 (1994-12-31), pages 42 *
HE XINLIANG: "Gas chromatographical analysis of feng-you-jing", JOURNAL OF PHARMACEUTICAL ANALYSIS, vol. 7, no. 3, 1987, pages 176 - 177 *
ZHOU ZIXIN: "The content determination of four naphta in feng-you-jing", CHINESE TRADITIONAL CHINESE MEDICINAL JOURNAL, vol. 21, no. 7, 1996, pages 418 - 419 *

Also Published As

Publication number Publication date
CN1424105A (zh) 2003-06-18
AU2003292859A1 (en) 2004-08-23

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