WO2004056326A2 - Composizioni per uso topico a base di un diamido - Google Patents
Composizioni per uso topico a base di un diamido Download PDFInfo
- Publication number
- WO2004056326A2 WO2004056326A2 PCT/IB2003/006092 IB0306092W WO2004056326A2 WO 2004056326 A2 WO2004056326 A2 WO 2004056326A2 IB 0306092 W IB0306092 W IB 0306092W WO 2004056326 A2 WO2004056326 A2 WO 2004056326A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- starch
- topical compositions
- compositions according
- topical
- mpa
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
Definitions
- the present invention relates to topical compositions comprising a bi-starch as excipient. STATE OF THE ART
- starch There exist many different types of starch according to the source, for example wheat, maize, rice, potatoes, tapioca, peas, according to the variety thereof, and according to the different percentage of amylopectin and amylose. Starches are used both as such and modified by means of various physical or chemical methods.
- One of the physical methods is pre-gelatinization, whereby the starch undergoes a thermal treatment in the presence of water, thus losing its granular form and becoming soluble in cold water.
- chemical methods it is possible to cite oxidation, esterification, etherification, and cross-linking.
- esterification is generally obtained, by reaction, for example, of an anhydride of a mono or dicarboxylic acid or a salt of an inorganic acid, such as, for instance, phosphoric acid.
- a more complex molecule is obtained, i.e., a bi-starch in which each amide molecule is connected to the other molecule via a chain spacer represented by the residue of phosphoric acid or of the aforesaid dicarboxylic acid, which forms an ester with each of said amide molecules.
- Starch modified physically and chemically has multiple applications in industry, and above all in the food industry as thickening agent. It is moreover used in the cosmetics industry, once again as thickening agent.
- US 6.391.260 describes formulations for cosmetic use in the form of emulsions consisting of an aqueous phase, an oily phase, an emulsifier and a glyceryl starch cross-linked by reaction with epichlorohydrin.
- EP 689829 describes formulations for cosmetic use containing a starch modified with an amino multicarboxylate group.
- the presence of the oily component is indispensable in addition to the starch, said oily component in general being made up of paraffins, mineral oils, castor oil, etc., i.e., non-biodegradable materials.
- the present invention relates to water-based topical compositions which have a creamy consistency or are in the form of gels, are substantially free from oily substances, and contain a bi-starch as excipient.
- a further subject of the present invention are the aforesaid topical compositions for cosmetic use.
- Yet another subject of the present invention are the aforesaid topical compositions according to the present invention for pharmaceutical use, and hence containing at least one active pharmaceutical ingredient.
- Yet a further subject of the present invention are the aforesaid topical compositions for veterinary use, hence containing at least one active principle for veterinary use.
- compositions capable of enabling adsorption of an active cosmetic, veterinary, or pharmaceutical principle via topical route, through the skin, the scalp, and the oral and vaginal mucosae.
- the topical compositions that form the subject of the present invention have a biodegradablity of 100%.
- creamy consistency or in the form of gels is meant a composition for topical use having a Brookfield viscosity measured at 23°C and at 20 rpm comprised between 1000 mPa.s and 180,000 mPa.s.
- the topical compositions forming the subject of the present invention have a Brookfield viscosity of between 3000 mPa.s and 150,000 mPa.s, and even more preferably between 11 ,000 mPa.s and 60,000 mPa.s.
- each starch molecule is connected to the second starch molecule by means of a chain spacer, which is preferably chosen between:
- bi-starch is chosen in the class consisting of phosphate bi-starch, phosphate acetylated bi-starch , adipate acetylated bi-starch, phosphate hydroxypropylated bi-starch, and phosphate phosphated bi-starch.
- adipate acetylated bi-starch is used.
- bi-starch As likewise the other bi-starches mentioned above, are prepared according to the chemical reactions described in "STARCH: CHEMISTRY AND TECHNOLOGY R" chap. 10, Whistler et a/., 2nd edition, 1984.
- the bi-starch used in the preparation of the topical compositions forming the subject of the present invention is preferably pre-gelatinized i.e., it has undergone a thermal treatment in the presence of water, according to methods known to any person skilled in the art.
- this starch thus modified is dispersed in an aqueous solution, which is poured onto a rotating drum heated to a temperature of between 100°C and 130°C, operating at pressures of between 2 and 6 bar, so that, in contact with the surface of the drum, the dispersion "explodes", with consequent evaporation of the water in time intervals ranging from 30 seconds to 3 minutes.
- the bi-starch used in the preparation of the topical compositions forming the subject of the present invention has an amount of amylopectin higher than 50 wt%, and preferably higher than 90 wt%.
- the bi-starch is that of maize.
- a particularly preferred embodiment envisages that pre-gelatinized adipate acetylated bi-starch of maize is used for the preparation of the topical compositions forming the subject of the present invention.
- the topical compositions forming the subject of the present invention preferably contain the bi-starch in concentrations of between 4 wt% and 20 wt%, more preferably between 5 wt% and 11 wt%, and even more preferably between 6 wt% and 9 wt% calculated on the total Weight of said formulation.
- the topical compositions forming the subject of the present invention moreover contain emollients chosen in the class of the polyols and in particular are chosen from glycerine, sorbitol and corresponding analogues, such as for example mannitol, maltit ⁇ l, xylitol etc., or mixtures of said polyols.
- compositions forming the subject of the present invention consequently have a creamy consistency and appearance or are in the form of gels.
- Compositions for cosmetic use, which form a further subject of the present invention may possibly contain a further active ingredient suitable for cosmetic use, in addition to glycerine and sorbitol.
- topical compositions forming the subject of the present invention for cosmetic use mention may be made, for example, of hair gel containing in particular 20 wt% of glycerine, 20 wt% of sorbitol preferably in the form of a 70 wt% aqueous dispersion, between 6 wt% and 9 wt% of pre-gelatinized adipate acetylated bi-starch adipate of maize, and the remainder to reach 100 wt% is represented by water.
- topical compositions forming the subject of the present invention and in particular the topical compositions containing as further excipients glycerine and sorbitol are preferably prepared according to the following operating conditions: a) mixing glycerine and bi-starch, while adding gradually water during said mixing; b) adding, finally, sorbitol to the mixture coming from stage (a).
- topical composition forming the subject of the present invention.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003303190A AU2003303190A1 (en) | 2002-12-23 | 2003-12-19 | Bi-starch based compositions for topical use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI20022746 ITMI20022746A1 (it) | 2002-12-23 | 2002-12-23 | Composizioni per uso topico a base di un diamido. |
ITMI2002A002746 | 2002-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004056326A2 true WO2004056326A2 (it) | 2004-07-08 |
WO2004056326A3 WO2004056326A3 (it) | 2004-09-10 |
Family
ID=32676861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/006092 WO2004056326A2 (it) | 2002-12-23 | 2003-12-19 | Composizioni per uso topico a base di un diamido |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003303190A1 (it) |
IT (1) | ITMI20022746A1 (it) |
WO (1) | WO2004056326A2 (it) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022073A2 (en) * | 1995-01-18 | 1996-07-25 | National Starch And Chemical Investment Holding Corporation | Cosmetics containing thermally-inhibited starches |
EP0948958A2 (en) * | 1998-04-09 | 1999-10-13 | National Starch and Chemical Investment Holding Corporation | Non-ionically derivatized starches and their use in aerosol hair fixative compositions |
EP0948959A2 (en) * | 1998-04-09 | 1999-10-13 | National Starch and Chemical Investment Holding Corporation | Nonionically derivatized starches and their use in low voc, polyacrylic acid-containing hair fixative compositions |
FR2779648A1 (fr) * | 1998-06-15 | 1999-12-17 | Oreal | Composition cosmetique ou pharmaceutique se presentant sous forme de solide et pouvant etre deformable |
WO2001019404A1 (en) * | 1999-09-15 | 2001-03-22 | Avebe America, Inc. | Shear thickening pregelatinized starch |
US6248338B1 (en) * | 1996-07-08 | 2001-06-19 | National Starch And Chemical Investment Holding Corporation | Starchy cleaning and cosmetic care preparations |
WO2003084487A1 (de) * | 2002-04-11 | 2003-10-16 | Beiersdorf Ag | Haarpflegemittel vorgelatinisierte, quervernetzte stärkederivate enthaltend |
-
2002
- 2002-12-23 IT ITMI20022746 patent/ITMI20022746A1/it unknown
-
2003
- 2003-12-19 WO PCT/IB2003/006092 patent/WO2004056326A2/it not_active Application Discontinuation
- 2003-12-19 AU AU2003303190A patent/AU2003303190A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022073A2 (en) * | 1995-01-18 | 1996-07-25 | National Starch And Chemical Investment Holding Corporation | Cosmetics containing thermally-inhibited starches |
US6248338B1 (en) * | 1996-07-08 | 2001-06-19 | National Starch And Chemical Investment Holding Corporation | Starchy cleaning and cosmetic care preparations |
EP0948958A2 (en) * | 1998-04-09 | 1999-10-13 | National Starch and Chemical Investment Holding Corporation | Non-ionically derivatized starches and their use in aerosol hair fixative compositions |
EP0948959A2 (en) * | 1998-04-09 | 1999-10-13 | National Starch and Chemical Investment Holding Corporation | Nonionically derivatized starches and their use in low voc, polyacrylic acid-containing hair fixative compositions |
FR2779648A1 (fr) * | 1998-06-15 | 1999-12-17 | Oreal | Composition cosmetique ou pharmaceutique se presentant sous forme de solide et pouvant etre deformable |
WO2001019404A1 (en) * | 1999-09-15 | 2001-03-22 | Avebe America, Inc. | Shear thickening pregelatinized starch |
WO2003084487A1 (de) * | 2002-04-11 | 2003-10-16 | Beiersdorf Ag | Haarpflegemittel vorgelatinisierte, quervernetzte stärkederivate enthaltend |
Also Published As
Publication number | Publication date |
---|---|
WO2004056326A3 (it) | 2004-09-10 |
AU2003303190A8 (en) | 2004-07-14 |
AU2003303190A1 (en) | 2004-07-14 |
ITMI20022746A1 (it) | 2004-06-24 |
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