Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/20—Halogens; Compounds thereof
  • A61K8/21—Fluorides; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/25—Silicon; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• the present invention relates, generally, to zeolite granules including fluorine and silica as an abrasive at the same time, and toothpaste compositions including predetermined amounts of the zeolite granules. More specifically, the present invention is directed to zeolite granules for use in toothpastes, containing silica as an abrasive and fluorine to exhibit high anti-tartar and anti-plaque efficacies, and a toothpaste composition comprising the same.
• teeth cavities are known to be caused by foods with high sugar content and oral bacteria on the teeth having weak resistance. To protect against teeth cavities, the above causes should be addressed.
• the plaque is a membrane produced on the teeth by the oral bacteria, and changed to tartar due to the deposition of multivalent ions contained in the foods over time. Since such tartar is colored by color deposition and becomes brown, it makes an unfavorable impression and also causes periodontal diseases. Thus, the tartar should be preferably removed from the teeth.
• Korean Patent No. 012156 discloses a method of removing multivalent ions, such as calcium or magnesium, in the saliva, by using powders or granules of neutral zeolite (4A) resulting from neutralization of zeolite.
• the use of the neutralized zeolite leads to a decreased removal function of calcium or magnesium.
• the prepared toothpaste has a bitter taste due to the excessive addition of the zeolite.
• a toothpaste composition comprising a water-insoluble inorganic material (zeolite, synthetic alumino silicate, calcium diphosphate, etc.) mixed and then granulated with 5-10 wt% of an organic binder (polystyrene latex, polyacrylic stearate, wax, etc.) insoluble to water.
• an organic binder polystyrene latex, polyacrylic stearate, wax, etc.
• WO 02/45677 discloses that zeolite granules are used to remove the tartar and plaque from the teeth, however the zeolite granules alone exhibit poor abrading function and thus, an abrasive should be additionally used.
• Another object of the present invention is to provide a toothpaste composition having an excellent removal function of tartar from the teeth, obtained by a simplified preparation process while omitting a separate adding process of fluorine.
• zeolite granules for use in toothpaste include 10 to 50 wt% of silica as an abrasive, and 0.5 to 3 wt% of a fluorine compound as a strength enhancer, added to zeolite.
• a toothpaste composition of the present invention includes 0.5 to 40 wt% of the zeolite granules.
• Zeolite has a cation exchange capacity, thus acting to effectively remove plaque and tartar from the teeth.
• silica having an abrading function is used instead of an organic binder to prepare zeolite.
• silica has higher expansion efficiency than that of zeolite, upon dryness and wetness.
• the resulting granules are physically weak and thus fractured upon a stirring process to produce the toothpaste. Hence, such granules cannot be applied for the toothpaste.
• silica is suspended to water to prepare slurry, which is then added with fluoride (selected from the group consisting of hydrofluorosilic acid, sodium fluorosilicate, potassium fluorosilicate, hydrofluoric acid, sodium fluoride, potassium fluoride, monofluorophosphoric acid, sodium monofluorophosphate, potassium monofluorophosphate, magnesium fluorosilicate, and mixtures thereof).
• fluoride selected from the group consisting of hydrofluorosilic acid, sodium fluorosilicate, potassium fluorosilicate, hydrofluoric acid, sodium fluoride, potassium fluoride, monofluorophosphoric acid, sodium monofluorophosphate, potassium monofluorophosphate, magnesium fluorosilicate, and mixtures thereof.
• the fluoride is suitably added in the amount of 0.5-3.0 wt%. If the amount is less than the above lower limit, the resulting granules are very weak in strength, thus exhibiting no abrading function. Meanwhile, if the amount exceeds the above upper limit, the obtained granules are very strong and thus may damage the surface of the teeth.
• the strength required for the granules corresponds to the extent of the granule particles being broken when applied with 5-20 g of loads.
• the zeolite has excellent cation exchange capacity, and thus the amount of zeolite in the granules should be at least 47 wt%.
• the zeolite alone has high calcium ion-sequestering capacity of about 300 mg/g but is poor in strength, and hence cannot be used for toothpaste as it is. Even though the fluoride and silica are mixed together to enhance the strength of the granules, the calcium ion- sequestering capacity should be maintained at the level not less than 150 mg/g.
• the zeolite in the granules should be used in the amount not less than 47 wt%.
• the calcium ion-sequestering capacity of the toothpaste is maintained at the level not less than 25 mg/g.
• the zeolite may be added with silica and fluorine components and thus directly granulated.
• first granules may be additionally coated with a suspension having relatively high silica amount.
• the silica component is present in larger amounts on the granules, thus further increasing fracture strength.
• the first granules it is preferable that 5 to 15 wt% of silica is added to the zeolite.
• the suspension for surface coating it is preferable that 40 to 50 wt% of silica is added to the zeolite. Since the amount of silica is high on the surface of the granules, the coated layer becomes transparent while absorbing water.
• the prepared zeolite granules are dried at 100-120°C to have water content of 15 wt% or less, sintered in a rotary kiln at 250-350°C, and then sieved through a standard mesh of 0.1-1.0 mm, and preferably, 0.2-0.6 mm.
• the granules have a fracture strength of 7-16 g/number, with the variation of the strength, and a calcium ion-sequestering capacity of 175 mg/g.
• the slurry A was slowly introduced to form granules. After 20 min., the slurry B for coating was added to the granules and then the granulation was further performed for 20 min., thus obtaining coated granules.
• Such granules were dried at 105°C for 11 hours to have a water content of 13 wt%, and then passed through a rotary kiln having a length of 3.5 m and an inner diameter of 200 mm at 300°C, to prepare granules having a water content of 6 wt%, which were thereafter sieved through a 40-70 mesh, thereby obtaining desired granules for use in a toothpaste.
• the granules have a fracture strength of 14-20 g/number, with decreasing the variation of the strength. From this, it can be found that the strength of the granules resulting from the present example is further increased to the extent of 20- 30%, compared to that of the granules obtained in Preparative Example 1.
• a calcium ion-sequestering capacity is 158 mg/g.
• Granules for use in a toothpaste were prepared in the same manner as in Example 2, with the exception that 350g (50% solution 700g) of monofluorophosphoric acid as a fluorine compound was used.
• the obtained granules have a fracture strength of 25-30 g/number, which is too strong to use as toothpaste and tastes bitter.
• Each toothpaste composition was prepared according to known methods using components shown in Table 1, below. As such, the zeolite granules obtained in Preparative Example 2 were used.
• the sequestering capacity with respect to calcium ions mainly causing the tartar on the teeth was determined by measuring the ion binding capacity, and thus the anti-tartar efficacies of the toothpaste compositions of the present invention were compared.
• 1 g of respective compositions obtained in preparative examples and comparative preparative examples were dispersed in 50 g of water, added with 50 mL of 0.05 M EDTA solution, and then titrated with 0.05N calcium chloride solution.
• the results are shown in Table 2, below.
• Apatite (Ca 3 (PO ) 2 ) as a main component of the teeth was pulverized to the size of 2-3 mm and the surface thereof was abraded using a sand mill, to prepare an apatite ball.
• 10 g of the apatite ball was mixed with respective compositions obtained in preparative examples and comparative preparative examples to have 0.04% of fluorine, and allowed to stand at room temperature for 24 hours, washed with water, and then incorporated into 10 mL of an acetate buffer solution, pH 5.0, for 20 min.
• the Ca ion present in the solution was measured by use of an ICP, to compare the protection effects of fluorine against teeth cavities. The results are given in the following Table 3.
• the present invention provides fluorine-containing zeolite granules for use in toothpaste, and a toothpaste composition comprising the same.
• the prepared toothpaste is advantageous in terms of superior protection efficacies against teeth cavities and high anti-plaque and anti-tartar effects, and drastically increased storability.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
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• Veterinary Medicine (AREA)
• Chemical & Material Sciences (AREA)
• Inorganic Chemistry (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Cosmetics (AREA)

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Citations (5)

• 2003
  • 2003-06-24 WO PCT/KR2003/001235 patent/WO2004037219A1/en not_active Application Discontinuation
  • 2003-06-24 AU AU2003246282A patent/AU2003246282A1/en not_active Abandoned
  • 2003-06-25 KR KR1020030041665A patent/KR100556146B1/ko not_active IP Right Cessation

Patent Citations (5)

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