WO2003043680A1 - Procede pour faire fonctionner un dialyseur - Google Patents

Procede pour faire fonctionner un dialyseur Download PDF

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Publication number
WO2003043680A1
WO2003043680A1 PCT/SE2002/002145 SE0202145W WO03043680A1 WO 2003043680 A1 WO2003043680 A1 WO 2003043680A1 SE 0202145 W SE0202145 W SE 0202145W WO 03043680 A1 WO03043680 A1 WO 03043680A1
Authority
WO
WIPO (PCT)
Prior art keywords
dialysis machine
sodium chloride
line
water
dialysis
Prior art date
Application number
PCT/SE2002/002145
Other languages
English (en)
Inventor
Anders Felding
Original Assignee
Gambro Lundia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20286081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003043680(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR10-2004-7007786A priority Critical patent/KR20040068149A/ko
Priority to AU2002348565A priority patent/AU2002348565A1/en
Priority to US10/496,086 priority patent/US7387734B2/en
Priority to KR1020107025668A priority patent/KR101244119B1/ko
Priority to ES02782066.1T priority patent/ES2312636T5/es
Application filed by Gambro Lundia Ab filed Critical Gambro Lundia Ab
Priority to DE60229428T priority patent/DE60229428D1/de
Priority to JP2003545358A priority patent/JP4235555B2/ja
Priority to EP02782066.1A priority patent/EP1450879B2/fr
Priority to CA2461552A priority patent/CA2461552C/fr
Publication of WO2003043680A1 publication Critical patent/WO2003043680A1/fr
Priority to US11/472,448 priority patent/US20060237351A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A61M1/1607—Physical characteristics of the dialysate fluid before use, i.e. upstream of dialyser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/166—Heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1666—Apparatus for preparing dialysates by dissolving solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1668—Details of containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A61M1/1682—Sterilisation or cleaning before or after use both machine and membrane module, i.e. also the module blood side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A61M1/1686—Sterilisation or cleaning before or after use by heat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/28—Apparatus therefor

Definitions

  • the present invention relates to a method of priming or rinse back of an extracorporeal circuit using a dialysis machine.
  • the invention further relates to a dialysis machine comprising means for preparing a saline solution.
  • the purpose of priming the circuit is to remove air from the blood lines and the dialyser as well as to remove possible fragments of remaining sterilising agents or other residuals from the disposables elements, such as bloodlines and dialysers that form the extracorporeal circuit, before the patient is connected. Rinse back is performed to avoid loss of patient blood that would otherwise remain in the extracorporeal circuit.
  • the conventional way of doing this is to use for instance a 2 liters bag of physiological saline solution of which 1.5 liters is used for priming of the circuit and 0.5 liters is used for rinse back of the blood to the patient after the treatment.
  • Modern dialysis equipment can perform so called on-line treatments, which means that the substitution fluid for hemofiltration or hemodiafiltration is prepared on-line by means of ultrafiltration of dialysis fluid in several steps to obtain a sterile and pyrogen free fluid.
  • On-line prepared substitution fluid can be prepared in practically unlimited quantities which means that this fluid also can be used for priming, bolus and rinse back purposes which also is cost saving and convenient from a handling point of view.
  • substitution fluid has to contain a high concentration of bicarbonate.
  • Infusing priming liquid with this volume and composition into the patient often causes problems, e.g. not well feeling. This problem is known from "Gambro AK 200 ULTRA operator's manual HCEN9568. Rev 12.1999 and cautioned for in all on-line systems. Clinics experiencing such problems often go back to priming with saline from bags.
  • the sodium chloride concentrate is prepared by dissolving solid sodium chloride in water.
  • the arterial line is connected to the dialysis machine through an infusion line which preferably includes an ultrafilter.
  • the saline solution comprises minor amounts of other electrolytes and other components for the dialysis liquid, such as potassium, calcium, magnesium, glucose with or without acid such as citric acid, hydrochloric acid and acetic acid,
  • the water from said source of water and/or said saline solution is passed through one or more ultrafilters for removal of bacteria and endotoxins.
  • the saline solution is substantially physiological with a sodium ion concentration about 154 mmol/1.
  • This object is achieved in accordance with claim 11 by providing a dialysis machine with separate sources of bicarbonate concentrate and sodium chloride concentrate and means to prepare a mix of the liquids from said source of water and said source of sodium chloride concentrate to obtain a saline solution.
  • the dialysis machine comprises a conductivity cell downstream of said mixing point.
  • the dialysis machine further comprises means to adjust the mixing ratio of said water and said sodium chloride concentrate, preferably in response to a signal from the conductivity cell.
  • the dialysis machine further comprises an infusion line connected to the outlet of the dialysis machine, said infusion line preferably including an ultrafilter.
  • the dialysis machine further comprises at least one ultrafilter in the flow path of said water.
  • Figure 1 is a schematic diagram of a dialysis machine according to the invention.
  • dialysis as used here includes hemodialysis, hemofiltration, hemodiafiltration and therapeutic plasma exchange (TPE), among other similar treatment procedures.
  • dialyzer as used here includes hemofilters and hemodiafilters amongst other similar devices. ⁇
  • saline solution as used here includes any solution comprising saline, preferably a substantially physiological saline solution.
  • solutions comprising saline described as substantially physiological saline solutions, are approved by the health and/or regulatory authorities in the country in which they are used. Therefore, these saline solutions comprising saline may differ somewhat in their composition in different countries, but a physiologically acceptable saline solution is always a solution that is physiological acceptable used, or when administered to a patient.
  • An example of an acceptable physiological saline may be a solution comprised of about 0.85% salt and distilled water; this solution approximately, therefore, being equal to the salt content of blood serum and thereby able to maintain normal osmotic pressure in the body.
  • saline solution as used here also includes in any solution containing minor amounts of other electrolytes and other components such as those normally used in preparing for the dialysis liquid, and can include, for example, potassium, calcium, magnesium, glucose and/or acid, as long as the solution remains substantially physiological: a typical solution with a sodium ion concentration may contain, for example, about 154 mmol/1. Deviations from this concentration in the range of 150 to 158 mmol/1 are tolerable.
  • a dialysis machine includes a dialyser 50 having two compartments 51 and 52 that are separated by a semi- permeable membrane 54.
  • the compartment 51 is connected to a circuit for convening a flow of blood outside the body of a patient comprising an upstream duct 80, usually referred to as arterial line, having a peristaltic pump 84 disposed therein, and a downstream duct 70, usually referred to as venous line.
  • Nenous line 70 is provided with a bubble trap 74 and the free ends of the ducts of the arterial and venous lines can be fitted respective needles or catheter connections to enable them to be connected to the vascular circuit of a patient.
  • the dialysis machine comprises a system for preparing dialysis fluid from dialysate fluid concentrate and/or powder including a heating reservoir 10 having an inlet 12 for water from for example a reverse osmosis unit. An ultra filter 11 is placed between the water inlet 12 and the tank 10. A dry powder vessel 20 containing bicarbonate is disposed in duct 21. A part of the water in the heating reservoir 10 is flown through the vessel 20 by a precisely controlled pump 22. Thus, a saturated bicarbonate solution is obtained from the vessel 20, and mixed into the main duct 5 at mixing point 17.
  • the dialysis fluid preparation system further comprises a duct 23 for preparing sodium chloride concentrate.
  • a dry powder vessel 15 containing sodium chloride is disposed in duct 23.
  • a part of the water in the heating reservoir 10 is flown through the vessel 15 by a precisely controlled pump 16.
  • Pump 16 is connected to the vessel 15 by a duct 14.
  • a saturated sodium chloride solution is obtained from the vessel 16 and mixed into the main duct 5 at mixing point 7.
  • the remaining electrolytes used in dialysis fluid e.g. potassium, calcium, magnesium, and other substances such as glucose and acid are added into duct 5 at mixing point 7 by withdrawing a concentrate solution containing from a small bag or canister 26 by means of a metering pump 28 in duct 31.
  • Pumps 16, 22 and 28 are controlled by a control unit 58. Downstream of mixing points 7 and 17 conductivity cells 9 and 19 monitor the conductivity change caused by the introduction of the respective electrolytes in the main duct 5. The signal of the respective conductivity cell is in a closed loop manner compared with the expected conductivity determined by the control unit 58. When the actual conductivity differs from the expected the control unit 58 adjusts the respective pump 16 and 22 in order to arrive at the correct conductivity and composition of the dialysate fluid.
  • the main duct includes a pump 8 and in normal dialysis operation (not shown) directs the dialysate fluid to an inlet of compartment 52 of the dialyser 50.
  • an outlet of the compartment 52 is connected to a downstream duct 61 having an extraction pump 64 disposed therein for establishing variable suction inside the compartment 52.
  • the duct 61 leads to a waste liquid (ultrafiltrate and/or processed dialysis liquid) container 67.
  • Duct 5 leading to compartment 52 and duct 61 leading away from compartment 52 both pass a flow rate cell 40.
  • the dialysis machine is provided with input means 59 allowing an operator to select a mode of operation in which the dialysis machine prepares a saline or a saline like solution, hi this mode of operation pumps 22 and 28 are not operated.
  • the conductivity set value for the conductivity cell 9 downstream of mixing point 7 is set to a value corresponding to a solution having a sodium chloride concentration of 154 mmol/1 and pump 16 is controlled accordingly.
  • an infusion line 44 is connected to the main duct 5.
  • the main duct 5 comprises a second ultrafilter 48.
  • the infusion line 44 includes another ultrafilter
  • the infusion line 44 is primed with the saline solution and then the infusion line is connected to the arterial bloodline 80 by connector 85 and the priming of the extracorporeal circuit begins.
  • the venous bloodline 70 is typically connected to a waste bag
  • the control unit 58 of the dialysis machine is connected to a sensor (not shown) that detects the presence of blood in the extraco ⁇ oreal blood circuit.
  • the control unit 58 adjusts the settings of the pumps 16, 22 and 28 and the conductivity cells 9 and 19 to values for preparing dialysate fluid with a composition in accordance with the settings of the operator.
  • the usual setting for sodium ions is for instance 140 mmol/1 and the usual setting for bicarbonate ions is 34 mmol/1.
  • the infusion line is connected to the arterial bloodline again whilst the venous bloodline remains connected to the patient (not shown)
  • the control unit 58 sets the pumps 16, 22 and 28 for preparing a saline solution and by means of pump 8 the saline solution is transported into the extraco ⁇ oreal circuit to rinse back the patient blood.
  • the saline solution is produced by mixing sodium chloride concentrate coming from vessel 15 and the concentrate of vessel 26 with the water in the main duct 5.
  • the resulting saline solution will, apart from sodium chloride, contain some minor amounts of other electrolytes and some acid, but this does not pose any problem for the patients.
  • chamber 52 of the dialyser is also filled with the saline solution.
  • chamber 52 is connected to the main duct 5 as in the dialysis treatment (not shown), and the saline solution is pumped into chamber 52.
  • the vessel 15 containing sodium chloride in dry form is primed by drawing water in from heating vessel 10 though activation of pump 16.
  • Line 31 is primed by running pump 28 at high speed until a fluid flow is detected.
  • the vessel 20 containing sodium bicarbonate does not have to be primed until the patient is comiected. If it is primed anyway before the saline preparation has started, the main duct 5 is rinsed from bicarbonate before the saline preparation begins.
  • the vessels 15 and 20 containing the electrolytes in dry form do not necessarily have to be cartridges as shown in the accompanying drawings. Bags, or any other kind of containers are equally suitable.
  • the fluid preparation system does not have to be based on the use of a flow rate cell 40.
  • the present invention will operate also with fluid preparation systems using the balance chamber principle.

Abstract

L'invention concerne un procédé et un appareil pour amorcer ou rincer en retour un circuit extracorporel au moyen d'un dialyseur équipé d'un système de préparation de liquide de dialyse. Le dialyseur sert à préparer une solution saline en ligne. Le circuit extracorporel est connecté au dialyseur et amorcé avec la solution saline.
PCT/SE2002/002145 2001-11-23 2002-11-22 Procede pour faire fonctionner un dialyseur WO2003043680A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA2461552A CA2461552C (fr) 2001-11-23 2002-11-22 Procede pour faire fonctionner un dialyseur
AU2002348565A AU2002348565A1 (en) 2001-11-23 2002-11-22 Method of operating a dialysis machine
US10/496,086 US7387734B2 (en) 2001-11-23 2002-11-22 Method of operating a dialysis machine
KR1020107025668A KR101244119B1 (ko) 2001-11-23 2002-11-22 투석기 작동 방법
ES02782066.1T ES2312636T5 (es) 2001-11-23 2002-11-22 Método de cebado de una máquina de diálisis
KR10-2004-7007786A KR20040068149A (ko) 2001-11-23 2002-11-22 투석기 작동 방법
DE60229428T DE60229428D1 (de) 2001-11-23 2002-11-22 Verfahren zum initialisieren eines dialysegeräts
JP2003545358A JP4235555B2 (ja) 2001-11-23 2002-11-22 体外回路のプライミング方法および透析装置
EP02782066.1A EP1450879B2 (fr) 2001-11-23 2002-11-22 Procede pour initialiser un dialyseur
US11/472,448 US20060237351A1 (en) 2001-11-23 2006-06-22 Method of operating a dialysis machine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0103907A SE525132C2 (sv) 2001-11-23 2001-11-23 Metod vid manövrering av dialysanordning
SE0103907-2 2001-11-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/472,448 Division US20060237351A1 (en) 2001-11-23 2006-06-22 Method of operating a dialysis machine

Publications (1)

Publication Number Publication Date
WO2003043680A1 true WO2003043680A1 (fr) 2003-05-30

Family

ID=20286081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2002/002145 WO2003043680A1 (fr) 2001-11-23 2002-11-22 Procede pour faire fonctionner un dialyseur

Country Status (11)

Country Link
US (2) US7387734B2 (fr)
EP (1) EP1450879B2 (fr)
JP (1) JP4235555B2 (fr)
KR (3) KR101244119B1 (fr)
AT (1) ATE411060T1 (fr)
AU (1) AU2002348565A1 (fr)
CA (1) CA2461552C (fr)
DE (1) DE60229428D1 (fr)
ES (1) ES2312636T5 (fr)
SE (1) SE525132C2 (fr)
WO (1) WO2003043680A1 (fr)

Cited By (56)

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CN100435863C (zh) * 2006-01-10 2008-11-26 赵滨宇 单路血液透析循环装置
WO2011161055A1 (fr) * 2010-06-23 2011-12-29 Gambro Lundia Ab Composition de précurseur pour la dialyse
WO2012000637A1 (fr) * 2010-06-29 2012-01-05 Fresenius Medical Care Deutschland Gmbh Dispositif fonctionnel médical, fluide de traitement et appareil de traitement médical
EP2535070A1 (fr) * 2007-10-24 2012-12-19 Baxter International Inc Système d'hémodialyse personnel
WO2014121167A1 (fr) * 2013-02-02 2014-08-07 Medtronic, Inc. Système de gestion de ph et de tampon pour des systèmes d'hémodialyse
WO2014121168A1 (fr) * 2013-02-02 2014-08-07 Medtronic, Inc. Système de gestion de sodium pour hémodialyse
US9192707B2 (en) 2011-04-29 2015-11-24 Medtronic, Inc. Electrolyte and pH monitoring for fluid removal processes
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US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US9616161B2 (en) 2011-06-20 2017-04-11 Gambro Lundia Ab Dialysis precursor composition
US9687507B2 (en) 2011-12-21 2017-06-27 Gambro Lundia Ab Dialysis precursor composition
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US9713668B2 (en) 2012-01-04 2017-07-25 Medtronic, Inc. Multi-staged filtration system for blood fluid removal
US9724298B2 (en) 2012-03-08 2017-08-08 Gambro Lundia Ab Method to form a dialysis composition comprising citrate, calcium and magnesium
US9821102B2 (en) 2011-06-20 2017-11-21 Gambro Lundia Ab Dialysis precursor composition
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
US9833470B2 (en) 2011-12-21 2017-12-05 Gambro Lundia Ab Dialysis precursor composition
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9855379B2 (en) 2013-02-02 2018-01-02 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9872949B2 (en) 2013-02-01 2018-01-23 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US9925155B2 (en) 2012-12-18 2018-03-27 Gambro Lundia Ab Dialysis composition
US9943633B2 (en) 2009-09-30 2018-04-17 Medtronic Inc. System and method to regulate ultrafiltration
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US10076283B2 (en) 2013-11-04 2018-09-18 Medtronic, Inc. Method and device to manage fluid volumes in the body
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US10478545B2 (en) 2013-11-26 2019-11-19 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
US10543052B2 (en) 2013-02-01 2020-01-28 Medtronic, Inc. Portable dialysis cabinet
US10595775B2 (en) 2013-11-27 2020-03-24 Medtronic, Inc. Precision dialysis monitoring and synchronization system
US10695481B2 (en) 2011-08-02 2020-06-30 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US10857277B2 (en) 2011-08-16 2020-12-08 Medtronic, Inc. Modular hemodialysis system
US10874787B2 (en) 2014-12-10 2020-12-29 Medtronic, Inc. Degassing system for dialysis
US10881777B2 (en) 2013-01-09 2021-01-05 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US10926017B2 (en) 2014-06-24 2021-02-23 Medtronic, Inc. Modular dialysate regeneration assembly
US10981148B2 (en) 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
US10994064B2 (en) 2016-08-10 2021-05-04 Medtronic, Inc. Peritoneal dialysate flow path sensing
US11013843B2 (en) 2016-09-09 2021-05-25 Medtronic, Inc. Peritoneal dialysis fluid testing system
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