WO2003006429A1 - Synthesis of taxol enhancers - Google Patents

Synthesis of taxol enhancers Download PDF

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Publication number
WO2003006429A1
WO2003006429A1 PCT/US2002/021716 US0221716W WO03006429A1 WO 2003006429 A1 WO2003006429 A1 WO 2003006429A1 US 0221716 W US0221716 W US 0221716W WO 03006429 A1 WO03006429 A1 WO 03006429A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
substituted
nhr
phenyl
aliphatic
Prior art date
Application number
PCT/US2002/021716
Other languages
English (en)
French (fr)
Inventor
Shoujun Chen
Lijun Sun
Zhi-Qiang Xia
Keizo Koya
Mitsunori Ono
Original Assignee
Synta Pharmaceuticals Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp. filed Critical Synta Pharmaceuticals Corp.
Priority to JP2003512201A priority Critical patent/JP2004534847A/ja
Priority to KR10-2004-7000333A priority patent/KR20040026679A/ko
Priority to AU2002316625A priority patent/AU2002316625B2/en
Priority to CA002453415A priority patent/CA2453415A1/en
Priority to EP02746946A priority patent/EP1406868A1/en
Priority to MXPA04000245A priority patent/MXPA04000245A/es
Publication of WO2003006429A1 publication Critical patent/WO2003006429A1/en
Priority to NO20040053A priority patent/NO20040053L/no
Priority to AU2006203689A priority patent/AU2006203689A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
PCT/US2002/021716 2001-07-10 2002-07-10 Synthesis of taxol enhancers WO2003006429A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2003512201A JP2004534847A (ja) 2001-07-10 2002-07-10 タキソール増強剤の合成
KR10-2004-7000333A KR20040026679A (ko) 2001-07-10 2002-07-10 택솔 인핸서의 합성
AU2002316625A AU2002316625B2 (en) 2001-07-10 2002-07-10 Synthesis of taxol enhancers
CA002453415A CA2453415A1 (en) 2001-07-10 2002-07-10 Synthesis of taxol enhancers
EP02746946A EP1406868A1 (en) 2001-07-10 2002-07-10 Synthesis of taxol enhancers
MXPA04000245A MXPA04000245A (es) 2001-07-10 2002-07-10 Sintesis de mejoradores de taxol.
NO20040053A NO20040053L (no) 2001-07-10 2004-01-07 Syntese av taxol forsterkende midler
AU2006203689A AU2006203689A1 (en) 2001-07-10 2006-08-24 Synthesis of taxol enhancers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30431801P 2001-07-10 2001-07-10
US60/304,318 2001-07-10

Publications (1)

Publication Number Publication Date
WO2003006429A1 true WO2003006429A1 (en) 2003-01-23

Family

ID=23176001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021716 WO2003006429A1 (en) 2001-07-10 2002-07-10 Synthesis of taxol enhancers

Country Status (11)

Country Link
US (4) US6825235B2 (US07652168-20100126-C00012.png)
EP (1) EP1406868A1 (US07652168-20100126-C00012.png)
JP (1) JP2004534847A (US07652168-20100126-C00012.png)
KR (1) KR20040026679A (US07652168-20100126-C00012.png)
CN (2) CN100398516C (US07652168-20100126-C00012.png)
AU (2) AU2002316625B2 (US07652168-20100126-C00012.png)
CA (1) CA2453415A1 (US07652168-20100126-C00012.png)
MX (1) MXPA04000245A (US07652168-20100126-C00012.png)
NO (1) NO20040053L (US07652168-20100126-C00012.png)
TW (1) TWI252847B (US07652168-20100126-C00012.png)
WO (1) WO2003006429A1 (US07652168-20100126-C00012.png)

Cited By (13)

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JP2008504264A (ja) * 2004-06-23 2008-02-14 シンタ ファーマスーティカルズ コーポレイション 癌治療のためのビス（チオ‐ヒドラジドアミド）塩
WO2009073148A2 (en) * 2007-11-28 2009-06-11 Synta Pharmaceuticals Corp. Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide)
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
US7652168B2 (en) 2001-07-10 2010-01-26 Synta Pharmaceuticals Corp. Synthesis of taxol enhancers
US7671092B2 (en) 2001-07-10 2010-03-02 Synta Pharmaceuticals Corp. Paclitaxel enhancer compounds
US7678832B2 (en) 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
US7750042B2 (en) 2001-07-10 2010-07-06 Synta Pharmaceuticals Corp. Paclitaxel enhancer compound
US7763658B2 (en) 2003-01-15 2010-07-27 Synta Pharmaceuticals Corp. Treatment for cancers
US7939564B2 (en) 2006-08-31 2011-05-10 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
US8017654B2 (en) 2005-04-15 2011-09-13 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
WO2013144228A1 (en) 2012-03-29 2013-10-03 Basf Se Pesticidal methods using heterocyclic compounds and derivatives for combating animal pests
US9156783B2 (en) 2006-08-21 2015-10-13 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders

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EP1827410A2 (en) * 2004-11-19 2007-09-05 Synta Pharmaceuticals Corporation Bis(thio-hydrazide amides) for increasing hsp70 expression
WO2006062732A2 (en) * 2004-11-19 2006-06-15 Synta Pharmaceuticals Corp. Compounds acting at the centrosome
WO2006113572A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
KR20080008399A (ko) * 2005-05-16 2008-01-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 염의 합성 방법
AU2007288334A1 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
US20080176828A1 (en) * 2006-08-21 2008-07-24 Martin Williams Treating melanoma with BIS(THIOHYDRAZIDE AMIDES)
AU2007288340A1 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis (thiohydrazide amides) for treating melanoma
CN101134057B (zh) * 2006-09-01 2011-04-27 中山大学 含紫杉醇的天然植物提取物的复方药物及其抗癌应用
US20080118562A1 (en) * 2006-09-11 2008-05-22 Keizo Koya Bis(thiohydrazide amides) formulation
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
US20090093538A1 (en) * 2007-01-03 2009-04-09 Synta Pharmaceuticals Corp Method for treating cancer
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8581004B2 (en) 2008-02-21 2013-11-12 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
MX2011004276A (es) 2008-10-22 2011-06-27 Synta Pharmaceuticals Corp Complejos de metales de transicion de compuestos bis (tiohidrazida amida).
EP2373624A4 (en) 2008-10-22 2014-06-11 Synta Pharmaceuticals Corp TRANSITION METAL COMPLEXES OF A TO [THIOHYDRAZIDAMID] COMPOUND
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
AU2009322603B2 (en) 2008-12-01 2013-08-29 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
US8815945B2 (en) 2010-04-20 2014-08-26 Masazumi Nagai Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
JP2014534238A (ja) 2011-11-10 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）化合物の投与
US20150057357A1 (en) 2012-01-05 2015-02-26 The Board Of Trustees Of The Leland Stanford Junior University Bis (thiohydrazide amide) compounds for treating cancers
CN115572249A (zh) * 2022-09-21 2023-01-06 南京红云生物科技有限公司上海分公司 一种铜离子螯合剂及其制备方法

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US20040229952A1 (en) 2004-11-18
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US20090005594A1 (en) 2009-01-01
EP1406868A1 (en) 2004-04-14
US7435843B2 (en) 2008-10-14
US7652168B2 (en) 2010-01-26
US7074952B2 (en) 2006-07-11
CA2453415A1 (en) 2003-01-23
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