WO2002100819A1 - N-arylphenylacetamide derivatives and medicinal compositions containing the same - Google Patents
N-arylphenylacetamide derivatives and medicinal compositions containing the same Download PDFInfo
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- WO2002100819A1 WO2002100819A1 PCT/JP2002/005586 JP0205586W WO02100819A1 WO 2002100819 A1 WO2002100819 A1 WO 2002100819A1 JP 0205586 W JP0205586 W JP 0205586W WO 02100819 A1 WO02100819 A1 WO 02100819A1
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- represents hydrogen
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003503589A JPWO2002100819A1 (ja) | 2001-06-11 | 2002-06-06 | N−アリールフェニルアセトアミド誘導体及びそれを含有する医薬組成物 |
CA002448764A CA2448764A1 (en) | 2001-06-11 | 2002-06-06 | N-arylphenylacetamide derivatives and pharmaceutical compositions containing the same |
MXPA03011448A MXPA03011448A (es) | 2001-06-11 | 2002-06-06 | Derivados de n-arilfenilacetamida y composicion farmaceutica que los contienen. |
BR0210297-8A BR0210297A (pt) | 2001-06-11 | 2002-06-06 | Derivados de n-arilfenilacetamida e composição farmacêutcia contendo os mesmos |
KR10-2003-7016120A KR20040017227A (ko) | 2001-06-11 | 2002-06-06 | 엔-아릴페닐아세트아미드 유도체 및 이를 함유하는약제학적 조성물 |
AU2002306269A AU2002306269B2 (en) | 2001-06-11 | 2002-06-06 | N-arylphenylacetamide derivatives and pharmaceutical composition containing the same |
EP02733338A EP1403235A4 (en) | 2001-06-11 | 2002-06-06 | N-ARLYPHENYLACETAMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING SAID DERIVATIVES |
US10/480,377 US7084176B2 (en) | 2001-06-11 | 2002-06-06 | N-arylphenylacetamide derivatives and medicinal compositions containing the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001176252 | 2001-06-11 | ||
JP2001-176252 | 2001-06-11 |
Publications (1)
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PCT/JP2002/005586 WO2002100819A1 (en) | 2001-06-11 | 2002-06-06 | N-arylphenylacetamide derivatives and medicinal compositions containing the same |
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US (1) | US7084176B2 (ja) |
EP (1) | EP1403235A4 (ja) |
JP (1) | JPWO2002100819A1 (ja) |
KR (1) | KR20040017227A (ja) |
CN (1) | CN1282640C (ja) |
AU (1) | AU2002306269B2 (ja) |
BR (1) | BR0210297A (ja) |
CA (1) | CA2448764A1 (ja) |
MX (1) | MXPA03011448A (ja) |
TW (1) | TWI239942B (ja) |
WO (1) | WO2002100819A1 (ja) |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2168975A (en) * | 1984-12-20 | 1986-07-02 | Procter & Gamble | Amides and compositions thereof having anti-inflammatory and analgesic activity |
EP0525360A2 (en) * | 1991-07-30 | 1993-02-03 | Korea Research Institute Of Chemical Technology | Novel phenylacetamide derivatives and processes for the preparation thereof |
EP0721939A1 (en) * | 1995-01-10 | 1996-07-17 | Korea Research Institute of Chemical Technology | N-arylalkylphenylacetamide derivatives |
WO1999029674A1 (en) * | 1997-12-11 | 1999-06-17 | Janssen Pharmaceutica N.V. | Retinoic acid mimetic anilides |
WO2001023347A1 (en) * | 1999-09-29 | 2001-04-05 | Novo Nordisk A/S | Novel aromatic compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013759A (en) * | 1985-06-10 | 1991-05-07 | The Procter & Gamble Company | Compounds and compositions having anti-inflammatory and analgesic activity |
ES2061624T3 (es) | 1987-03-09 | 1994-12-16 | Procter & Gamble | Compuestos fenilicos sustituidos con amino-etilo en posicion beta, y composiciones anti-inflamatorias o analgesicas que los contienen. |
HU210683B (en) | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
IT1302264B1 (it) | 1998-09-24 | 2000-09-05 | Innovet Italia Srl | Derivati a struttura n-acil vanillinamidica in grado di attivare irecettori periferici dei cannabinoidi |
-
2002
- 2002-06-05 TW TW091112065A patent/TWI239942B/zh not_active IP Right Cessation
- 2002-06-06 CN CNB028143124A patent/CN1282640C/zh not_active Expired - Fee Related
- 2002-06-06 US US10/480,377 patent/US7084176B2/en not_active Expired - Fee Related
- 2002-06-06 WO PCT/JP2002/005586 patent/WO2002100819A1/ja not_active Application Discontinuation
- 2002-06-06 CA CA002448764A patent/CA2448764A1/en not_active Abandoned
- 2002-06-06 BR BR0210297-8A patent/BR0210297A/pt not_active IP Right Cessation
- 2002-06-06 KR KR10-2003-7016120A patent/KR20040017227A/ko not_active Application Discontinuation
- 2002-06-06 AU AU2002306269A patent/AU2002306269B2/en not_active Ceased
- 2002-06-06 EP EP02733338A patent/EP1403235A4/en not_active Withdrawn
- 2002-06-06 MX MXPA03011448A patent/MXPA03011448A/es active IP Right Grant
- 2002-06-06 JP JP2003503589A patent/JPWO2002100819A1/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2168975A (en) * | 1984-12-20 | 1986-07-02 | Procter & Gamble | Amides and compositions thereof having anti-inflammatory and analgesic activity |
EP0525360A2 (en) * | 1991-07-30 | 1993-02-03 | Korea Research Institute Of Chemical Technology | Novel phenylacetamide derivatives and processes for the preparation thereof |
EP0721939A1 (en) * | 1995-01-10 | 1996-07-17 | Korea Research Institute of Chemical Technology | N-arylalkylphenylacetamide derivatives |
WO1999029674A1 (en) * | 1997-12-11 | 1999-06-17 | Janssen Pharmaceutica N.V. | Retinoic acid mimetic anilides |
WO2001023347A1 (en) * | 1999-09-29 | 2001-04-05 | Novo Nordisk A/S | Novel aromatic compounds |
Non-Patent Citations (1)
Title |
---|
See also references of EP1403235A4 * |
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Also Published As
Publication number | Publication date |
---|---|
CN1529692A (zh) | 2004-09-15 |
KR20040017227A (ko) | 2004-02-26 |
EP1403235A1 (en) | 2004-03-31 |
TWI239942B (en) | 2005-09-21 |
JPWO2002100819A1 (ja) | 2004-09-24 |
EP1403235A4 (en) | 2006-08-30 |
US20040248983A1 (en) | 2004-12-09 |
AU2002306269B2 (en) | 2007-07-05 |
MXPA03011448A (es) | 2004-07-01 |
CA2448764A1 (en) | 2002-12-19 |
CN1282640C (zh) | 2006-11-01 |
BR0210297A (pt) | 2004-07-13 |
US7084176B2 (en) | 2006-08-01 |
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