WO2002092608A3 - Utilisation d'une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant - Google Patents

Utilisation d'une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant Download PDF

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Publication number
WO2002092608A3
WO2002092608A3 PCT/FR2002/001657 FR0201657W WO02092608A3 WO 2002092608 A3 WO2002092608 A3 WO 2002092608A3 FR 0201657 W FR0201657 W FR 0201657W WO 02092608 A3 WO02092608 A3 WO 02092608A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
reagent
same
ionic nature
fluorination
Prior art date
Application number
PCT/FR2002/001657
Other languages
English (en)
Other versions
WO2002092608A2 (fr
Inventor
Vincent Schanen
Jean-Francis Spindler
Maxime Garayt
Boulaire Virginie Le
Danielle Gree
Rene Gree
Original Assignee
Rhodia Chimie Sa
Vincent Schanen
Jean-Francis Spindler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0106531A external-priority patent/FR2824831A1/fr
Priority claimed from FR0205984A external-priority patent/FR2839716A1/fr
Priority to EP02732875A priority Critical patent/EP1401844A2/fr
Priority to CA002445459A priority patent/CA2445459A1/fr
Priority to AU2002304483A priority patent/AU2002304483A1/en
Priority to US10/477,497 priority patent/US7393980B2/en
Application filed by Rhodia Chimie Sa, Vincent Schanen, Jean-Francis Spindler filed Critical Rhodia Chimie Sa
Priority to HU0400827A priority patent/HUP0400827A3/hu
Priority to JP2002589491A priority patent/JP2004529956A/ja
Priority to MXPA03010352A priority patent/MXPA03010352A/es
Publication of WO2002092608A2 publication Critical patent/WO2002092608A2/fr
Publication of WO2002092608A3 publication Critical patent/WO2002092608A3/fr
Priority to US12/113,232 priority patent/US20090036718A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
    • C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
    • C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne une nouvelle méthode pour réaliser des substitutions nucléophiles, notamment de type SNAr et SN2. Elle vise plus particulièrement l'utilisation comme milieu réactionnel fluorant de liquide ionique ou de sel fondu comportant au moins quatre atomes de carbone. Application à la synthèse de dérivés fluorure.
PCT/FR2002/001657 2001-05-17 2002-05-16 Utilisation d'une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant WO2002092608A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA03010352A MXPA03010352A (es) 2001-05-17 2002-05-16 Uso de una composicion de naturaleza ionica como reactivo de sustitucion, composicion que constituye un reactivo de fluoracion y metodo que la utiliza.
JP2002589491A JP2004529956A (ja) 2001-05-17 2002-05-16 置換試薬としてのイオン性の組成物の使用、フッ素化試薬を構成する組成物およびそれを用いる方法
CA002445459A CA2445459A1 (fr) 2001-05-17 2002-05-16 Utilisation d'une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant
AU2002304483A AU2002304483A1 (en) 2001-05-17 2002-05-16 Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same
US10/477,497 US7393980B2 (en) 2001-05-17 2002-05-16 Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same
EP02732875A EP1401844A2 (fr) 2001-05-17 2002-05-16 Utilisation d' une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant
HU0400827A HUP0400827A3 (en) 2001-05-17 2002-05-16 Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same
US12/113,232 US20090036718A1 (en) 2001-05-17 2008-05-01 Use of a composition of an ionic nature as a substitution reagent, a composition constituting a fluorination reagent and a method using same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0106531A FR2824831A1 (fr) 2001-05-17 2001-05-17 Composition utile comme reactif de substitution nucleophile, son utilisation et procede l'utilisant
FR01/06531 2001-05-17
FR0205984A FR2839716A1 (fr) 2002-05-15 2002-05-15 Utilisation d'une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant
FR02/05984 2002-05-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/113,232 Continuation US20090036718A1 (en) 2001-05-17 2008-05-01 Use of a composition of an ionic nature as a substitution reagent, a composition constituting a fluorination reagent and a method using same

Publications (2)

Publication Number Publication Date
WO2002092608A2 WO2002092608A2 (fr) 2002-11-21
WO2002092608A3 true WO2002092608A3 (fr) 2003-12-24

Family

ID=26213016

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/001657 WO2002092608A2 (fr) 2001-05-17 2002-05-16 Utilisation d'une composition de nature ionique comme reactif de substitution, composition constituant un reactif de fluoration et procede l'utilisant

Country Status (9)

Country Link
US (2) US7393980B2 (fr)
EP (1) EP1401844A2 (fr)
JP (2) JP2004529956A (fr)
CN (1) CN100545133C (fr)
AU (1) AU2002304483A1 (fr)
CA (1) CA2445459A1 (fr)
HU (1) HUP0400827A3 (fr)
MX (1) MXPA03010352A (fr)
WO (1) WO2002092608A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100441153B1 (ko) * 2002-03-14 2004-07-21 주식회사 씨트리 유기 불소화합물의 제조방법
PT102937A (pt) * 2003-04-09 2004-10-29 Reis De Aguiar Navarro Y Rosa Novos liquidos ionicos baseados na unidade tetra-alquil-dimetil-guanidinio
DE10325051A1 (de) 2003-06-02 2004-12-23 Merck Patent Gmbh Ionische Flüssigkeiten mit Guanidinium-Kationen
US7569703B2 (en) * 2003-12-25 2009-08-04 Sumitomo Chemical Company, Limited Fluorinating agent and method for producing fluorine-containing compound using the same
DE102004033525A1 (de) * 2004-07-08 2006-02-02 Lanxess Deutschland Gmbh Verbessertes Verfahren zur Herstellung kernfluorierter Aromaten
DE102004053662A1 (de) * 2004-11-03 2006-05-04 Basf Ag Verfahren zur Herstellung von Polyisocyanaten
JP5479697B2 (ja) * 2008-08-26 2014-04-23 日本曹達株式会社 フッ化ジスルフィド化合物の製造方法
CN102471477B (zh) * 2009-07-24 2014-09-03 因温斯特技术公司 使用离子液体的合成方法
TW201609651A (zh) 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（一）
TW201609652A (zh) 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（三）
BR102014028164A2 (pt) * 2013-11-12 2015-09-08 Dow Agrosciences Llc processo para fluoração de compostos
TWI726900B (zh) 2015-08-04 2021-05-11 美商陶氏農業科學公司 用於氟化化合物之過程
CN107141192B (zh) * 2017-05-09 2019-10-11 大连奇凯医药科技有限公司 一种均三氟苯的制备方法
CN108586257B (zh) * 2018-05-03 2020-12-22 浙江解氏新材料股份有限公司 一种对氟硝基苯的制备方法
CN111504933B (zh) * 2020-05-12 2022-12-06 扬州工业职业技术学院 一种分析检测抗艾滋病新药的方法
JP7381912B2 (ja) * 2021-10-13 2023-11-16 ダイキン工業株式会社 フッ素含有芳香族化合物の製造方法
JP2023150474A (ja) * 2022-03-31 2023-10-16 ダイキン工業株式会社 フッ素含有芳香族化合物の製造方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1998005610A2 (fr) * 1996-08-07 1998-02-12 Aventis Research & Technologies Gmbh & Co Kg Procede de preparation de composes fluores
WO2000037400A1 (fr) * 1998-12-18 2000-06-29 Ineos Chlor Limited Halogenation dans des liquides ioniques
FR2791670A1 (fr) * 1999-03-31 2000-10-06 Rhodia Chimie Sa Procede d'activation de substrats aromatiques par micro-ondes
WO2001087900A1 (fr) * 2000-05-18 2001-11-22 Cytec Technology Corp. Sels de phosphonium

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JPS60228436A (ja) * 1984-04-27 1985-11-13 Asahi Glass Co Ltd 芳香族化合物のフツ素化方法
DE3827436A1 (de) * 1988-08-12 1990-02-15 Bayer Ag Verfahren zum einfuehren von fluoratomen an aromatische kerne durch nucleophilen austausch
JPH02117624A (ja) * 1988-10-27 1990-05-02 Showa Denko Kk フッ素化剤
DE59106553D1 (de) * 1990-06-25 1995-10-26 Hoechst Ag Verfahren zur herstellung von chlorfluornitrobenzolen und difluornitrobenzolen.
JP2501723B2 (ja) * 1991-07-17 1996-05-29 ヘキスト・アクチェンゲゼルシャフト クロロフルオロニトロベンゼンの製造方法
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005610A2 (fr) * 1996-08-07 1998-02-12 Aventis Research & Technologies Gmbh & Co Kg Procede de preparation de composes fluores
WO2000037400A1 (fr) * 1998-12-18 2000-06-29 Ineos Chlor Limited Halogenation dans des liquides ioniques
FR2791670A1 (fr) * 1999-03-31 2000-10-06 Rhodia Chimie Sa Procede d'activation de substrats aromatiques par micro-ondes
WO2001087900A1 (fr) * 2000-05-18 2001-11-22 Cytec Technology Corp. Sels de phosphonium

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BHADURY, PINAKI S. ET AL: "A semi-molten mixture of hexadecyltributylphosphonium bromide and potassium fluoride in the synthesis of organofluorine compounds", JOURNAL OF FLUORINE CHEMISTRY (1999), 99(2), 115-117, XP004363094 *

Also Published As

Publication number Publication date
US7393980B2 (en) 2008-07-01
JP2008044944A (ja) 2008-02-28
JP2004529956A (ja) 2004-09-30
WO2002092608A2 (fr) 2002-11-21
AU2002304483A1 (en) 2002-11-25
CN1529684A (zh) 2004-09-15
US20090036718A1 (en) 2009-02-05
HUP0400827A3 (en) 2006-03-28
CA2445459A1 (fr) 2002-11-21
US20040144947A1 (en) 2004-07-29
EP1401844A2 (fr) 2004-03-31
CN100545133C (zh) 2009-09-30
MXPA03010352A (es) 2004-03-16
HUP0400827A2 (hu) 2004-07-28

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