WO2002076935A8 - Nouveau derive de l'acide lipoique et son utilisation - Google Patents

Nouveau derive de l'acide lipoique et son utilisation

Info

Publication number
WO2002076935A8
WO2002076935A8 PCT/JP2002/002577 JP0202577W WO02076935A8 WO 2002076935 A8 WO2002076935 A8 WO 2002076935A8 JP 0202577 W JP0202577 W JP 0202577W WO 02076935 A8 WO02076935 A8 WO 02076935A8
Authority
WO
WIPO (PCT)
Prior art keywords
novel
acid derivative
lipoic acid
inhibitory activity
formula
Prior art date
Application number
PCT/JP2002/002577
Other languages
English (en)
French (fr)
Other versions
WO2002076935A1 (fr
Inventor
Kazumi Ogata
Takahiro Sakaue
Kazuhiko Ito
Original Assignee
Senju Pharma Co
Kazumi Ogata
Takahiro Sakaue
Kazuhiko Ito
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co, Kazumi Ogata, Takahiro Sakaue, Kazuhiko Ito filed Critical Senju Pharma Co
Priority to US10/472,726 priority Critical patent/US7700080B2/en
Priority to JP2002576197A priority patent/JP4072062B2/ja
Priority to AT02705321T priority patent/ATE446949T1/de
Priority to DE60234164T priority patent/DE60234164D1/de
Priority to EP02705321A priority patent/EP1371640B1/en
Publication of WO2002076935A1 publication Critical patent/WO2002076935A1/ja
Publication of WO2002076935A8 publication Critical patent/WO2002076935A8/ja
Priority to US12/715,131 priority patent/US20100152288A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
PCT/JP2002/002577 2001-03-19 2002-03-18 Nouveau derive de l'acide lipoique et son utilisation WO2002076935A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/472,726 US7700080B2 (en) 2001-03-19 2002-03-18 Method of suppressing melanin production by metal chelates of lipoyl amino acid derivatives
JP2002576197A JP4072062B2 (ja) 2001-03-19 2002-03-18 新規α−リポ酸誘導体およびその用途
AT02705321T ATE446949T1 (de) 2001-03-19 2002-03-18 Neues a-liponsäurederivat und dessen verwendung
DE60234164T DE60234164D1 (de) 2001-03-19 2002-03-18 Neues a-liponsäurederivat und dessen verwendung
EP02705321A EP1371640B1 (en) 2001-03-19 2002-03-18 Novel a-lipoic acid derivative and use thereof
US12/715,131 US20100152288A1 (en) 2001-03-19 2010-03-01 NOVEL a-LIPOIC ACID DERIVATIVES AND APPLICATIONS THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001078571 2001-03-19
JP2001-78571 2001-03-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/715,131 Continuation US20100152288A1 (en) 2001-03-19 2010-03-01 NOVEL a-LIPOIC ACID DERIVATIVES AND APPLICATIONS THEREOF

Publications (2)

Publication Number Publication Date
WO2002076935A1 WO2002076935A1 (fr) 2002-10-03
WO2002076935A8 true WO2002076935A8 (fr) 2002-10-31

Family

ID=18935167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/002577 WO2002076935A1 (fr) 2001-03-19 2002-03-18 Nouveau derive de l'acide lipoique et son utilisation

Country Status (7)

Country Link
US (2) US7700080B2 (ja)
EP (1) EP1371640B1 (ja)
JP (1) JP4072062B2 (ja)
AT (1) ATE446949T1 (ja)
DE (1) DE60234164D1 (ja)
ES (1) ES2331832T3 (ja)
WO (1) WO2002076935A1 (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647612B2 (en) * 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
US7935332B2 (en) 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US7914815B2 (en) * 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
US8697109B2 (en) 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
US8147816B2 (en) * 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
US20050112113A1 (en) * 2000-08-16 2005-05-26 Till Jonathan S. Presbyopia treatment by lens alteration
DE60234164D1 (de) * 2001-03-19 2009-12-10 Senju Pharma Co Neues a-liponsäurederivat und dessen verwendung
AU2003264412A1 (en) * 2002-09-13 2004-04-30 Oga Research, Incorporated Melanin extinguisher
AU2003284337B2 (en) * 2002-10-25 2010-04-15 Precision Dermatology, Inc. Modulation of zinc levels to improve tissue properties
JP2008174453A (ja) * 2005-04-28 2008-07-31 Iwaki Kk 頭皮脱毛治療剤
JP2007254423A (ja) * 2006-03-24 2007-10-04 Dhc Co シート状パック材及びシート状パック材の品質保持方法
DE102007038849A1 (de) 2007-08-16 2009-02-19 Adscil Gmbh Verwendung von R(+)-alpha-Liponsäure zur Behandlung der kryptogenen Neuropathie
US8102027B2 (en) * 2007-08-21 2012-01-24 Broadcom Corporation IC package sacrificial structures for crack propagation confinement
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
US9044439B2 (en) 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
US20090258841A1 (en) 2008-04-01 2009-10-15 Michael Patrick Murphy Compositions and methods for skin care
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
EP3542629A3 (en) 2009-06-15 2020-01-01 Encore Health, LLC Dithiol compounds, derivatives, and uses therefor
PL2442645T3 (pl) 2009-06-15 2015-02-27 Encore Health Llc Estry choliny
KR101368179B1 (ko) 2010-11-12 2014-03-03 포항공과대학교 산학협력단 강한 전하를 가지는 나노입자 표면 분자체와 이를 이용한 생접합 및 층상 자기조립 방법
DK2640423T3 (en) * 2010-11-18 2017-10-02 Ischemix Llc LIPOYL COMPOUNDS AND THEIR USE IN TREATMENT OF ISchemic DAMAGE
ITFI20120170A1 (it) * 2012-08-28 2014-03-01 Consorzio Interuniversitario Nazion Ale Per La Sci Nuovi composti ad azione anti-allodinica ed anti-iperalgesica.
JP2017509617A (ja) 2014-02-27 2017-04-06 コンソルツィオ インターユニヴァーシタリオ ナチオナーレ ペル ラ シエンツァ エ テクノロジア デイ マテリアーリ 抗異痛活性および抗痛覚過敏活性を有する新規化合物
CA2941518A1 (en) 2014-03-03 2015-09-11 Encore Vision, Inc. Lipoic acid choline ester compositions and methods of use
CN107427433B (zh) * 2015-04-18 2020-10-20 捷鸥化妆品株式会社 酪氨酸酶活性抑制剂及皮肤外用剂
JP6752551B2 (ja) * 2015-04-18 2020-09-09 ジェイオーコスメティックス株式会社 チロシナーゼ活性阻害剤および皮膚外用剤
EP3615023B1 (en) 2017-04-25 2023-06-21 Ischemix LLC Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB935962A (en) 1960-06-17 1963-09-04 Fujisawa Pharmaceutical Co Improvements in or relating to the production of 6.8-dithiooctanamides
JPS6011494A (ja) * 1983-06-29 1985-01-21 Sumitomo Chem Co Ltd 有機ゲルマニウム化合物
JPS638316A (ja) * 1986-06-28 1988-01-14 Sansho Seiyaku Kk 外用剤
FR2710340B1 (fr) 1993-09-22 1995-12-15 D Hinterland Lucien Dussourd Dérivés peptidiques de l'alpha-MSH et leur application .
US6365623B1 (en) 1997-11-17 2002-04-02 Nicholas V. Perricone Treatment of acne using lipoic acid
FR2781157B1 (fr) * 1998-07-15 2000-08-25 Oreal Composition anti-inflammatoire
AU6001299A (en) * 1998-10-02 2000-04-26 Sankyo Company Limited Dithiol derivatives
JP2000169371A (ja) 1998-10-02 2000-06-20 Sankyo Co Ltd ジチオラン誘導体を含有する医薬
CA2348998C (en) * 1998-10-26 2012-03-06 The Research Foundation Of State University Of New York Lipoic acid derivatives and their use in treatment of disease
JP2002535247A (ja) * 1998-11-26 2002-10-22 ペンタファルム アクチェンゲゼルシャフト 輸送系複合体
US6288106B1 (en) * 1999-05-25 2001-09-11 Chronorx, Llc Processes for the synthesis and use of various α-lipoic acid complexes
DE60234164D1 (de) * 2001-03-19 2009-12-10 Senju Pharma Co Neues a-liponsäurederivat und dessen verwendung

Also Published As

Publication number Publication date
EP1371640A1 (en) 2003-12-17
ATE446949T1 (de) 2009-11-15
US20040092586A1 (en) 2004-05-13
US20100152288A1 (en) 2010-06-17
DE60234164D1 (de) 2009-12-10
ES2331832T3 (es) 2010-01-18
JP4072062B2 (ja) 2008-04-02
EP1371640B1 (en) 2009-10-28
JPWO2002076935A1 (ja) 2004-07-15
US7700080B2 (en) 2010-04-20
EP1371640A4 (en) 2007-10-10
WO2002076935A1 (fr) 2002-10-03

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