WO2002072175A1 - Orifice d'injection de liquide chimique et recipient pour liquide chimique contenant ledit liquide chimique - Google Patents

Orifice d'injection de liquide chimique et recipient pour liquide chimique contenant ledit liquide chimique

Info

Publication number
WO2002072175A1
WO2002072175A1 PCT/JP2002/002003 JP0202003W WO02072175A1 WO 2002072175 A1 WO2002072175 A1 WO 2002072175A1 JP 0202003 W JP0202003 W JP 0202003W WO 02072175 A1 WO02072175 A1 WO 02072175A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection port
chemical
chemical liquid
passage
liquid
Prior art date
Application number
PCT/JP2002/002003
Other languages
English (en)
Japanese (ja)
Inventor
Nobuo Takagi
Takamitsu Ohkawara
Koji Munechika
Norihide Kishi
Tadaaki Inoue
Original Assignee
Nipro Corporation
Mitsubishi Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nipro Corporation, Mitsubishi Pharma Corporation filed Critical Nipro Corporation
Priority to JP2002571133A priority Critical patent/JP4408338B2/ja
Priority to KR20037011669A priority patent/KR100816974B1/ko
Publication of WO2002072175A1 publication Critical patent/WO2002072175A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents

Definitions

  • the present invention relates to a medicinal solution injection port for aseptically and easily performing co-injection of medicinal solutions, specifically, co-injection of another medicinal solution into an injection solution such as an infusion solution, and a medicinal solution provided with the medicinal solution injection port.
  • a medicinal solution injection port for aseptically and easily performing co-injection of medicinal solutions, specifically, co-injection of another medicinal solution into an injection solution such as an infusion solution, and a medicinal solution provided with the medicinal solution injection port.
  • Japanese Patent Application Laid-Open No. 9-184080 discloses a medical container for aseptically performing a co-injection operation.
  • This medical container comprises a cylindrical mouth member which is attached to the plastic container body in a liquid-tight manner, A rubber stopper that tightly seals, a housing that is communicated with a piercing portion that can pierce the rubber stopper, or that is integrally formed with the piercing portion; a sterilization filter that is supported by the housing; A co-injection port (chemical solution injection port) is provided, which houses the puncture portion, the housing, and the sterilization filter in a sterilized state, and includes a storage cover attached to the mouth member.
  • a co-injection port chemical solution injection port
  • This invention can inject a chemical
  • the purpose is to provide a drug solution container.
  • the present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, completed the present invention. That is, the present invention is as follows.
  • a liquid inlet that can be connected to a syringe, and at the other end, a liquid outlet that can be connected to a liquid container is formed.
  • a tubular body having a passage extending from the inlet to the drug solution outlet; a disinfecting filter provided in the passage;
  • Closing means provided between the sterilization filter and the chemical solution discharge port so as to close the passage and to open the passage when a chemical solution is injected into the passage from the chemical liquid inlet;
  • a chemical solution input port characterized by this.
  • the cylindrical body has an annular projecting portion projecting toward the passage, and the closing means is a film welded to the chemical solution outlet side of the ⁇ -shaped projecting portion.
  • the cylindrical body is composed of a first cylindrical member having a chemical liquid inlet, and a second cylindrical member having a chemical liquid outlet and an annular protrusion, and the first cylindrical member and the second cylindrical member.
  • the shielding means is a rubber cap fitted into the chemical inlet.
  • the rubber cap has an opening in a top surface thereof communicating with the passage, and the hole is formed by a gas filter.
  • a drug solution container provided with the drug solution injection port according to any one of [1] to [5].
  • FIG. 1 is a front view, partially cut away, showing a drug solution container provided with a drug solution injection port as a preferred example of the present invention.
  • FIG. 2 is an enlarged cross-sectional view showing a chemical injection port of the example of FIG.
  • FIG. 3 is a cross-sectional view schematically showing another preferred example of the liquid injection port of the present invention.
  • FIG. 4 is a cross-sectional view showing a simplified still another example of a liquid injection port according to the present invention.
  • FIG. 1 is a partially cutaway front view of a chemical container 1 having a preferable example of a chemical injection port 2 of the present invention
  • FIG. 2 is a schematic view of the chemical injection port 2 of the example of FIG. It is sectional drawing which expands and shows.
  • FIG. 2 is a cross-section including the axis of the chemical injection port 2.
  • the liquid injection port 2 of the present invention is a cylindrical body. 3, a disinfection filter 4 and a closing means 5 are basically provided.
  • the cylindrical body 3 is a substantially cylindrical, preferably cylindrical member, and a chemical solution that can be connected to a syringe at one end (hereinafter, sometimes referred to as “one axial side A1 side”).
  • An injection port 6 is formed, and a chemical solution discharge port 7 that can be connected to a chemical solution container is formed at an end of the other side (hereinafter, sometimes referred to as “the other axial direction A2 side”).
  • the cylinder 3 has a passage 9 extending from the chemical liquid inlet 6 to the chemical liquid outlet 7.
  • the chemical liquid inlet 6 may be any structure that can connect a syringe containing a chemical liquid to be co-injected. In the example shown in FIG.
  • the passage 9 is formed through the passage (a through hole 18 described later) from the middle. It is formed in a gently tapered shape such that the diameter gradually increases toward one side A1 in the axial direction, so that the luer tip portion of the luer tip type syringe can be fitted and connected.
  • the chemical solution outlet 7 may be any structure that can be connected to the chemical solution container, and in the example shown in FIG. 2, it is formed so as to expand outward at the end on the other side A2 in the axial direction, for example.
  • the flange portion 8 formed of a material that can be welded to the chemical solution container.
  • the sanitizing filter 4 is provided in the cylindrical body 3 in the middle of the passage 9.
  • a disinfecting filter 4 is not particularly limited, but is generally used in the art, such as a membrane type, a screen type, a depth type, and an anisotropic type. Each type of filter can be suitably used. Among them, it is particularly preferable to use a membrane filter. If the sterilizing filter 4 is a membrane-type real soul, its pore size (coarseness) is selected to be 0.01 im to l.O / im, which is a size that can prevent the passage of gentle bacteria. It is more preferable to select from 0.1 ⁇ to 0.5 m.
  • Materials for forming the sterilizing filter 4 include cellulose acetate, regenerated cenorellose, cellulose ester / ester, nylon, polytetrafluoroethylene, polystyrene, polycarbonate, acryl-based resin, and the like. Examples include, but are not limited to, polyolefin, polyvinylidene difluoride, and polyether sulfone.
  • the closing means 5 is provided so as to close the passage 9 between the sterilizing filter 4 and the chemical solution outlet 7.
  • the closing means 5 is not particularly limited as long as it closes the passage 9 so that the passage 9 can be opened when a chemical is injected into the passage 9 from the chemical inlet 6.
  • Such closing means 5 may be realized by a film welded to a cylindrical body as described later, or may be realized by a check valve.
  • the chemical liquid injection port 2 of the present invention having the above-described structure allows the chemical liquid injected from the chemical liquid inlet 6 to reach the closing means 5 when mounted on the chemical liquid container as shown in FIG. Since the closing means 5 is opened only for the first time, the chemical solution contained in the chemical solution container can be prevented from flowing out to the chemical solution injection port side at least before use (before the co-injection operation). In addition, since the liquid injection port 2 does not allow the closing means 5 to communicate the portion of the passage 9 closer to the liquid injection port 6 than the closing means 5 of the passage 9 with the internal space of the liquid medicine container, the liquid injection port 2 is not used. The chemical solution contained in the chemical solution container can be aseptically maintained before use, with G2 attached.
  • a syringe (not shown) containing another medicinal solution to be co-injected into the medicinal solution in the medicinal solution container (hereinafter, sometimes referred to as “co-injection solution”) is connected to the medicinal solution inlet 6.
  • the mixed injection liquid is injected into the passage 9 from the chemical liquid inlet 6.
  • the disinfecting filter 4 is provided in the middle of the passage 9, so that the mixed injection liquid after passing through the disinfecting filter 4 is sterilized.
  • the closing means 5 provided between 4 and the chemical solution discharge port 7, the closing means 5 is opened. After the closing means 5 is released, the mixed injection liquid is discharged from the chemical liquid outlet 7 and flows into the chemical liquid container, and mixes with the chemical liquid in the chemical liquid container.
  • the chemical liquid injection port 2 of the present invention is configured such that the passage 9 and the internal space of the chemical liquid container are communicated only after the mixed liquid is injected, the aseptic mixed injection operation can be reliably performed. With Wear. Therefore, it is not necessary to sterilize the mixed drug solution in the drug solution container 1 after the co-injection, and even the one that is likely to be deteriorated by the sterilization process can be used for the co-injection operation.
  • a chemical solution injection port capable of performing the aseptic co-injection operation as described above is sealed in a liquid-tight manner at an opening as disclosed in a conventional Japanese Patent Application Laid-Open No. 9-148080, for example.
  • the present invention can be realized without using a rubber stopper and a piercing portion capable of piercing the rubber stopper. Therefore, unlike the conventional case, coring does not occur when a rubber stopper is pierced, and foreign matter such as rubber chips does not enter the chemical solution container.
  • the chemical injection port is small and has a simple structure with a small number of parts, so the manufacturing cost is significantly reduced. can do.
  • co-infusion solution to be co-injected into the medicinal solution in the medicinal solution container using such a medicinal solution injecting port 2 of the present invention, but one that is likely to be altered by sterilization.
  • those which are extremely unstable, and those which are susceptible to a change in the composition due to sterilization treatment are exemplified as particularly preferable.
  • the cylindrical body 3 has a projecting portion of a ring projecting toward the passage 9, and the closing means 5 is realized by a film welded to the side of the annular projecting portion on the side of the chemical solution outlet 7.
  • the cylindrical body 3 has a substantially cylindrical peripheral wall 10, and an annular protrusion 11 protruding from the peripheral wall 10 toward the passage 9.
  • the annular projection 11 is welded to the chemical outlet 7 side, and more specifically, is welded to the annular rib 12 formed on the chemical outlet 7 side of the annular projection 11. An example is shown.
  • the film must be weakly welded so that the film easily peels off from the annular rib 12 due to the weight of the chemical when the chemical passes through the passage 9. Until the chemical reaches the closing means 5 and the welding is maintained to such an extent that the welding is maintained. It must be welded to the ribs 12.
  • the cylindrical body 3 includes a first cylindrical member 13 having the chemical liquid inlet 6 and a second cylindrical member having the chemical liquid outlet 7 and the annular protrusion 11. It is preferable that the first tubular member 13 and the second tubular member 14 are realized by being fitted to each other while holding the sterilization filter 4 therebetween.
  • the first cylindrical member 13 and the second cylindrical member 14 are fitted to each other while sandwiching the sterilizing quilter 4, so that the first cylindrical member 13 and the second cylindrical member 14 are provided in the middle of the passage 9.
  • a chemical solution injection port provided with the sterilization filter 4 can be easily manufactured.
  • the human first cylindrical member 13 has a support part 15, a fitting part 16, and a peripheral wall part 17, in addition to the chemical liquid inlet 6.
  • the support part 15 is a disc-shaped part and has a concentric through hole 18.
  • the chemical liquid inlet 6 is formed so as to rise from the periphery of the through hole 18 of the support portion 15 toward the one axial direction A1 side and coaxially.
  • the chemical liquid inlet 6 in the example shown in FIG. 2 is formed in a gently tapered shape such that the diameter gradually increases from the through hole 18 toward one side A 1 in the axial direction as described above. You.
  • the opening of the chemical liquid inlet 6 and the through hole 18 in the support 15 form a part of the passage 9 described above.
  • the fitting portion 16 is formed so as to be fitted to a fitting portion 19 of a second cylindrical member 14 described later.
  • the fitting portion 16 is formed as a concave portion that gradually becomes deeper in a so-called skirt shape toward the center axis, for example, on the other axial side A 2 of the support portion 15.
  • the peripheral wall portion 17 is a cylindrical portion formed on the outer periphery of the support portion 15, and the peripheral wall portion 17 forms a part of the peripheral wall 10 of the above-described cylindrical body 3.
  • FIG. 2 shows an example in which the liquid injection port 6 is formed so as to rise from the force supporter 15 toward the one axial side A 1 in the axial direction by the same distance as the peripheral wall 17. .
  • Examples of a material for forming such a first cylindrical member 13 include synthetic resins having chemical resistance such as polyethylene, polypropylene, polyvinyl chloride, polyester, and polycarbonate.
  • the second cylindrical member 14 has a fitting portion 19 and a peripheral wall portion 20 in addition to the chemical solution outlet 7 and the annular projecting portion 11.
  • the fitted portion 19 is formed so as to be fitted with the fitted portion 16 of the first cylindrical member 13 described above.
  • the fitted portion 19 is a convex portion having a stepwise height corresponding to the shape of the fitted portion 16 on the other axial side A 2 of the support portion 15. It is formed.
  • the peripheral wall portion 20 is a substantially cylindrical portion, and the first cylindrical member 13 and the second cylindrical member 14 are fitted together as shown in FIG. Together with the peripheral wall portion 17 of the cylindrical member 13, the peripheral wall 10 of the cylindrical body 3 is formed.
  • the annular protrusion 11 protrudes from the peripheral wall 20 toward the passage 9.
  • Examples of the material forming the second cylindrical member 14 include the same materials as those of the first cylindrical member 13 described above, such as polyethylene, polypropylene, polyvinyl chloride, polyester, and polycarbonate. Synthetic resin having the above chemical resistance.
  • the first tubular member 13 and the second tubular member 14 are formed of the same material if selected from the above synthetic resin materials. They may be formed of different materials, but are preferably formed of the same material.
  • a material that can be welded is selected from the above-described resin materials according to the material of the mating member to be welded.
  • the second cylindrical member and the flange portion may be formed separately, and if the second cylindrical member and the flange portion are connected to the container body by welding in this manner, at least the flange portion is formed of a material that can be welded. It should be done.
  • the closing means 5 is realized by a film welded to the annular rib 12 as described above.
  • the material for forming the film is not particularly limited as long as it has chemical resistance and can be welded to the annular rib 12.
  • the material for forming the second cylindrical member 14 described above is not particularly limited. (Material for forming the annular ribs 12) is appropriately selected.
  • the film forming material there is a case where the second cylindrical member 14 is formed of a polymer blend of a material for forming the second cylindrical member 14 and a resin having no compatibility with the material.
  • the second cylindrical member 14 is formed of polyethylene
  • a polymer blend of polyethylene and polypropylene is preferably used as a film forming material serving as the closing means 5.
  • the mixing ratio of polyethylene and polypropylene in the film is preferably 3: 7 to 7: 3.
  • the annular ribs 12 and the film may both be formed of polyethylene, and more preferably both, of high-density polyethylene. Even with such a combination of forming materials, the film can be welded to the annular rib 12 as described above.
  • the welding of the film to the annular projecting portion 11 may be performed by heating, ultrasonic induction, or high-frequency, induction heat generation as in the case of the conventionally known welding. Since it is intended to be peeled off by injecting a chemical solution from the inlet section 6, in the example of Fig. 2, welding is performed on the annular rib 12 having a semicircular cross section, in other words, the area of welding is reduced. it can
  • the above-mentioned weak welding has been realized by reducing the number of welds. In the present invention, the above-mentioned weak welding is realized by adjusting the welding conditions, not the area to be welded, for example, by lowering the heating temperature or shortening the heating time. Is also good.
  • the drug solution injection port 2 of the present invention is realized such that the drug solution inlet port 6 is aseptically shielded by a sealable means that can be opened before use.
  • the shielding means may be any one that can aseptically shield the chemical solution inlet 6 until the chemical solution injection port is used, in other words, a material that can substantially hermetically seal the chemical solution inlet 6. There is no particular limitation. Thus, the sterilized state of the passage 9 before use can be maintained.
  • FIG. 2 shows a sealing seal attached to the cylindrical body 3 as a shielding means so as to cover the entire opening of the chemical solution inlet 6 over the entire surface (indicated by a two-dot chain line 2 in the figure). 2) is used.
  • the hermetic seal 22 is realized by a film such as a sterilized paper, an aluminum film, for example, a film made of aluminum alone, a plastic film, a laminated film of an anore film and another plastic, or an aluminum film. If you want to co-inject the chemical at the chemical injection port 2, peel off the sealing seal 22 before use.
  • the chemical solution inlet 6 is formed so as to rise from the support portion 15 toward the one axial side A 1 by the same distance as the peripheral wall portion 17. If a sealing seal 22 is adhered to one end portion 1, 7 a of the peripheral wall portion 17 on one axial side, the opening of the chemical solution inlet 6 can be entirely covered with the sealing seal 22.
  • the peripheral wall portion 17 on the first cylindrical member 13 in this manner, the sticking and peeling of the hermetic seal 22 are easier than in the case where the peripheral wall portion is not formed.
  • the chemical liquid inlet may be formed so as to rise from the support portion toward one side in the axial direction by a distance smaller than the peripheral wall portion, and the above-described advantage can be obtained by such an embodiment.
  • Such a liquid injection port 2 can be suitably used as a liquid injection port for a liquid container as shown in FIG.
  • the chemical container is not particularly limited as long as it can be used for medical purposes.
  • the chemical solution container 1 in the example shown in FIG. 1 includes a container body 25 and a chemical solution discharge port 26 in addition to the chemical solution injection port 2.
  • the container body 25 is a container formed by laminating two sheets made of a flexible synthetic resin and welding the periphery thereof.
  • Materials for forming this container include polyethylene, polypropylene, soft polyester, vinyl chloride, ethylene-vinyl acetate copolymer, etc., especially low-density polyethylene, which has excellent chemical resistance, and Chain low-density polyethylene, polypropylene, etc. are preferably used.
  • the container body 25 contains a liquid such as an amino acid solution, a glucose solution, a solution containing an electrolyte, or a physiological saline solution.
  • the container body is not limited to the one having only one chamber as in the present example shown in FIG. 1, but may be one having two or more chambers separated by a partition wall. Further, in addition to the shape in which the sheets are overlapped, a tube-shaped member or the like can be used.
  • the chemical solution discharge port 26 is composed of a discharge port member 27 made of a synthetic resin molded article such as polyethylene or polypropylene, and a connection member formed of the same material as the discharge port member 27. 28, and a rubber stopper 29 supported by the discharge port member 27 and hermetically sealing the opening thereof in a liquid-tight manner.
  • the rubber stopper 29 and the inside of the container body 25 communicate with each other via a connecting member 28, and a bottle needle of an infusion set is pierced through the rubber stopper 29, and the medicinal solution contained inside the human body is removed. Will be administered.
  • the rubber stopper 29 may be made of any material that does not leak chemicals during infusion, and a rubber-like elastic body such as a thermoplastic elastomer may be used.
  • the medical solution discharge port is not limited to a shape in which a bottle needle of an infusion set is pierced through a rubber-like elastic body such as a rubber stopper 29 or the like. It may be shaped so that they are connected together.
  • the chemical solution and injection port 2 is a port for aseptically injecting the chemical solution into the container body 25 described above, a first cylindrical member having a chemical solution injection port 6 connectable to a syringe, and a closing means.
  • the sterilization filter 4 is sandwiched between the second cylindrical member 5 and the second cylindrical member, and the second cylindrical member is fixed to the connection port 30.
  • FIG. 3 is a cross-sectional view schematically showing a chemical injection port 46 of another preferred example of the present invention. Portions having the same configuration as the above-described liquid injection port 2 are denoted by the same reference numerals as those in FIG. 2, and description thereof will be omitted.
  • the chemical liquid injection port 46 of the embodiment shown in FIG. 3 has a shape corresponding to a luer-lock type (with a lock screw) syringe, for example, a female luer single-port structure. It is formed in such a shape.
  • the liquid inlet 47 that can be connected to the syringe more stably and stably can be realized. To perform a co-injection operation.
  • the chemical injection port of the present invention may be replaced with the hermetic seal 22 described above, and the rubber cap 48 may be replaced with the chemical injection port 47 as shown in FIG. It can be used as a shield to keep the sterile condition before use by fitting it into the opening.
  • the first tubular member 51 does not have a peripheral wall portion, and only the peripheral wall portion 20 of the second tubular member 14 has a cylindrical body 50. This is realized so as to form the peripheral wall 10.
  • such a rubber cap 48 is removed during the co-injection operation, but after the co-infusion operation, it can be fitted into the opening of the chemical liquid inlet 47 to prevent the mixed chemical solution from flowing back.
  • FIG. 4 is a simplified cross-sectional view showing a chemical solution injection port 56 of still another preferred embodiment of the present invention. Portions having the same configuration as the above-described liquid injection port 2 are denoted by the same reference numerals as in FIG. 2 and description thereof is omitted. As shown in FIG.
  • the chemical solution injection port 56 of the present invention has a shielding means whose top surface (in the rubber cap 57, the side fitted to the opening of the chemical solution inlet 47) This is realized by fitting a rubber cap (elastomer cap) 57 with a hole 58 formed with an opening 59 in 5a into the opening of the chemical inlet 47. Is also good.
  • the material for forming the rubber cap 57 is not particularly limited as long as it has rubber-like elasticity, and examples thereof include elastomers, ordinary natural rubber, butyl rubber, and polystyrene resins.
  • SEBS styrene-ethylene-butylene-styrene block copolymer
  • SBS copolymers
  • SIS styrene-isoprene-styrene block copolymers
  • olefin-based polymers such as ethylene-propylene copolymer copolymers
  • Thermoplastic elastomer can be preferably used.
  • the hole 58 in the rubber cap 57 has an opening 59 in the top surface 57a of the rubber cap 57, as described above, and the rubber cap 57, as shown in FIG. It is formed so as to communicate with the passage 9 of the chemical liquid injection port 56 and the external space in a state of being fitted into the opening of the injection port portion 47.
  • the diameter of the hole 58 is not particularly limited as long as it is smaller than the outer diameter of the liquid inlet 47, but usually, the diameter is 1 mm! A diameter of ⁇ 5 mm is adopted.
  • the hole 58 formed in the rubber cap 57 is closed by a gas filter (bactericidal filter) 60 so as to allow ventilation.
  • a gas filter 60 provided so as to cover the opening 59 from the outside (above the top surface 57 a).
  • the gas filter 60 is provided, for example, by being thermally welded to the top surface 57 a of the rubber cap 57.
  • the gas filter 60 has the same disinfection performance as the disinfection filter 4 described above, and has a pore size (high-temperature steam sterilization or ethylene oxide gas sterilization (EOG sterilization) described later) capable of sterilization. It is preferable that the material has a (roughness).
  • the pore size of the gas filter 60 is, for example, 0.011 to 1.0 ⁇ m, more preferably 0.01 // // ⁇ to 0.5 / zm.
  • the material for forming such a gas filter 60 is not particularly limited, and includes, for example, the same material as for the sterilization filter 4 provided in the passage 9.
  • the gas finoleta 60 is heat-welded to the top surface 57a so as to cover the opening 59 as described above, for example, polytetrafluoroethylene, polyvinylidene funoleoleide, tetranoroleo, etc.
  • a filter formed by laminating a material having good heat adhesion such as, for example, polyethylene or polypropylene as a material having poor heat adhesion such as an ethylene-hexafluoropropylene copolymer can be preferably used.
  • gas filter 60 may be provided in the middle of the hole 58 so as to block the hole 58 so as to allow ventilation.
  • gas can pass through the gas filter 60, so that it is not limited to the ⁇ -ray sterilization that was used when the rubber cap 48 shown in FIG. 3 was used.
  • Sterilization methods such as high-pressure steam sterilization and EOG sterilization can be adopted.
  • the above-mentioned drug solution injection port 56 is fixed to the connection port 30 of the drug solution container filled with the drug solution, and then subjected to high-pressure steam sterilization again. In this high-pressure steam sterilization, if a drying step is not provided after the sterilization, water droplets will remain in the passage 9.
  • a waterproof sheet (a portion 61 enclosed by a two-dot chain line in FIG. 4) is attached to the outside of the gas filter 60 by heat welding or the like to prevent this.
  • the waterproof sheet 61 is preferably made of a material such as polyethylene or polypropylene. Plastics, such as laminates and plastics made of aluminum and plastic, are used.
  • the liquid injection port 56 of the embodiment shown in FIG. 4 is different from the embodiments shown in FIGS. 2 and 3 in that the cylindrical body 62 has a first rectangular member 63 having a liquid injection port 47.
  • the first cylindrical member 63 And the second tubular member 64 are fitted to each other via the third tubular member 65 with the sterilization filter 4 held therebetween.
  • the first cylindrical member 63 and the second cylindrical member 64 both have no peripheral wall, and the peripheral wall 6 of the third cylindrical member 65 does not have a peripheral wall. 6 alone forms the peripheral wall of the cylindrical body 62.
  • the chemical solution discharge port member of the chemical solution container of the present invention is formed so as to have a peripheral wall and a rubber stopper fitted into the peripheral wall.
  • the configuration was such that the drug solution in the drug solution container was discharged by penetrating a bottle needle or the like, the present invention is not limited to this, and for example, a shape in which a drug solution discharge port member is connected by a connector. You may.
  • a drug solution injection port 46 of the present invention having the embodiment shown in FIG. 3 was produced.
  • the disinfecting filter 4 a nylon filter having a hole diameter of 0.2 // m was used.
  • high-density polyethylene was used.
  • the closing means 5 a polymer film of polyethylene and polypropylene was used.
  • the opening of the chemical solution inlet 47 is made of a styrene-based thermoplastic elastomer, SEBS (styrene-ethylene ⁇ butylene-styrene block coke). After fitting a rubber cap made of polymer, 7-line sterilization was performed.
  • SEBS styrene-ethylene ⁇ butylene-styrene block coke
  • a drug solution injection port 56 of the present invention having the embodiment shown in FIG. 4 was produced.
  • a filter made of polyvinylidene fluoride having a pore size of 0.2 ⁇ m was used as the sterilization filter 4 provided in the passage 9.
  • a rubber cap 57 made of SEBS and having a hole 58 with a diameter of 2 mni was fitted into the opening of the medicine inlet 47.
  • the top surface 57 a of the rubber cap 57 is laminated with polytetrafluoroethylene having a hole diameter of 0.2 m and high-density polyethylene so as to cover the opening 59 of the hole 58.
  • a gas filter 60 was thermally welded.
  • high-density polyethylene was used as a material for forming the first tubular member 63, the second tubular member 64, and the third tubular member 65.
  • the closing means 5 a polymer blend fi / rem of polyethylene and polypropylene was used.
  • the gas filter 60 is covered using a polyethylene seal as the waterproof sheet 61, and the top surface 57 After heat-sealing and affixing to a, the whole was subjected to high-pressure steam sterilization.
  • a chemical solution can be aseptically injected without the occurrence of coring, the number of parts is small, and the chemical solution injection port has a smaller and simplified structure than the conventional one. And a drug solution container provided with the drug solution injection port.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un orifice d'injection de liquide chimique qui comporte : sur une extrémité, un corps cylindrique et une partie orifice d'injection de liquide chimique conçue pour être reliée à une seringue ; sur l'autre extrémité, un orifice de décharge de liquide chimique conçu pour être relié à un récipient pour liquide chimique ; un passage reliant la partie orifice d'injection de liquide chimique à l'orifice de décharge de liquide chimique ; un filtre de séparation des micro-organismes installé dans le passage ; un dispositif de fermeture installé entre le filtre de séparation des micro-organismes et l'orifice de décharge de liquide chimique, ce dispositif étant destiné à fermer le passage et conçu pour ouvrir le passage lorsque le liquide chimique est injecté dans le passage par la partie orifice d'injection de liquide chimique ; enfin un récipient contenant ledit liquide chimique.
PCT/JP2002/002003 2001-03-05 2002-03-05 Orifice d'injection de liquide chimique et recipient pour liquide chimique contenant ledit liquide chimique WO2002072175A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002571133A JP4408338B2 (ja) 2001-03-05 2002-03-05 薬液注入ポートおよびそれを備える薬液容器
KR20037011669A KR100816974B1 (ko) 2001-03-05 2002-03-05 약액 주입 포트 및 그것을 구비하는 약액 용기

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001-60438 2001-03-05
JP2001060438 2001-03-05
JP2001230530 2001-07-30
JP2001-230530 2001-07-30

Publications (1)

Publication Number Publication Date
WO2002072175A1 true WO2002072175A1 (fr) 2002-09-19

Family

ID=26610642

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/002003 WO2002072175A1 (fr) 2001-03-05 2002-03-05 Orifice d'injection de liquide chimique et recipient pour liquide chimique contenant ledit liquide chimique

Country Status (4)

Country Link
JP (2) JP4408338B2 (fr)
KR (1) KR100816974B1 (fr)
CN (1) CN1254280C (fr)
WO (1) WO2002072175A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437115A1 (fr) * 2001-09-14 2004-07-14 Nipro Corporation Orifice d'alimentation en produit chimique et recipient pour produit chimique pourvu de cet orifice
JP2008525122A (ja) * 2004-12-23 2008-07-17 ホスピラ・インコーポレイテツド 静脈内流体容器用のポート閉鎖システム
JP2009509683A (ja) * 2005-09-29 2009-03-12 アルコン，インコーポレイティド 二室型溶液包装システム
US8136330B2 (en) 2004-12-23 2012-03-20 Hospira, Inc. Medical fluid container

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170121667A1 (en) * 2014-03-27 2017-05-04 Hitachi Chemical Company, Ltd. Cell capture device, cell capture filter, cell capture apparatus, and method for manufacturing cell capture device
KR101875518B1 (ko) * 2017-05-08 2018-07-10 (주)에이디켐테크 개방이 용이한 플라스틱 백

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1084942A (ja) * 1996-09-19 1998-04-07 Terumo Corp 容器連結体および細菌培養方法
JPH10328269A (ja) * 1997-05-30 1998-12-15 Material Eng Tech Lab Inc 医療用容器
JP2002035086A (ja) * 2001-04-24 2002-02-05 Mitsubishi Pharma Corp 栓体付き薬液容器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0232588Y2 (fr) * 1984-10-30 1990-09-04
JPH06116Y2 (ja) * 1989-10-30 1994-01-05 キヨーラク株式会社 輸液用プラスチック容器
JPH0852196A (ja) * 1994-08-09 1996-02-27 Material Eng Tech Lab Inc 薬剤連結口を有する輸液容器
JPH09173416A (ja) * 1995-12-22 1997-07-08 Material Eng Tech Lab Inc 医療用容器の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1084942A (ja) * 1996-09-19 1998-04-07 Terumo Corp 容器連結体および細菌培養方法
JPH10328269A (ja) * 1997-05-30 1998-12-15 Material Eng Tech Lab Inc 医療用容器
JP2002035086A (ja) * 2001-04-24 2002-02-05 Mitsubishi Pharma Corp 栓体付き薬液容器

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437115A1 (fr) * 2001-09-14 2004-07-14 Nipro Corporation Orifice d'alimentation en produit chimique et recipient pour produit chimique pourvu de cet orifice
EP1437115A4 (fr) * 2001-09-14 2006-11-29 Nipro Corp Orifice d'alimentation en produit chimique et recipient pour produit chimique pourvu de cet orifice
US7322969B2 (en) 2001-09-14 2008-01-29 Nipro Corporation Liquid-medicine injection port device, and liquid-medicine container provided with the same
JP2008525122A (ja) * 2004-12-23 2008-07-17 ホスピラ・インコーポレイテツド 静脈内流体容器用のポート閉鎖システム
US8034041B2 (en) 2004-12-23 2011-10-11 Hospira, Inc. Port closure system for intravenous fluid container
US8034042B2 (en) 2004-12-23 2011-10-11 Hospira, Inc. Port closure system for intravenous fluid container
US8136330B2 (en) 2004-12-23 2012-03-20 Hospira, Inc. Medical fluid container
JP2009509683A (ja) * 2005-09-29 2009-03-12 アルコン，インコーポレイティド 二室型溶液包装システム

Also Published As

Publication number Publication date
JP4408338B2 (ja) 2010-02-03
CN1254280C (zh) 2006-05-03
KR20030088450A (ko) 2003-11-19
JP2009178584A (ja) 2009-08-13
KR100816974B1 (ko) 2008-03-26
JPWO2002072175A1 (ja) 2004-10-07
CN1501819A (zh) 2004-06-02

Similar Documents

Publication Publication Date Title
AU2005322136B2 (en) Port closure system for intravenous fluid container
US20090270832A1 (en) Needleless port assembly for a container
US20090192484A1 (en) Port closure system for intravenous fluid container
JP3820889B2 (ja) 輸液容器
JP2009178584A (ja) 薬液注入ポートおよびそれを備える薬液容器
US20090105684A1 (en) Medication port for medical fluid container
JP4004106B2 (ja) 薬液注入器具
JP4366131B2 (ja) 複室容器
JP3949124B2 (ja) キャップおよび既充填薬液容器
JP2000107257A (ja) 輸液用容器
JP2004290218A (ja) 薬剤入り多室バッグ及びポート部材
JPH09173416A (ja) 医療用容器の製造方法
JP2011131104A (ja) 医療用複室容器
JPH0919480A (ja) 医療用容器
JP3634560B2 (ja) 既充填薬液容器
JP2001009006A (ja) 複室容器
WO2003000170A1 (fr) Bouche de recipient destinee a au traitement de melangeage et de remplissage et recipient d'infusion utilisant ladite bouche
JP2009154024A (ja) 複室容器
JP2007267877A (ja) 医療用容器
JPH0975425A (ja) 医療用容器
JPH09108302A (ja) 医療用容器及びその製造方法
JPH10165479A (ja) 医療用容器
JP3949125B2 (ja) マルチ針付きホルダー
AU2011265422B2 (en) Port closure system for intravenous fluid container
JPH08238299A (ja) 医療用容器

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002571133

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 028059433

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 1020037011669

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1020037011669

Country of ref document: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase