Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
  • C07C51/42—Separation; Purification; Stabilisation; Use of additives

Definitions

• the invention relates to stabilized compositions of o-iodoxybenzoic acid, or IBX, of formula
• This hypervalent iodine derivative is the precursor of 1, 1, 1 -triacetoxy-1, 1 - d ⁇ hydro-1, 2-benzodioxol-3 (1 H) -one or periodinane of Dess-Martin, of formula
• IBX can be prepared by oxidation of 2-iodobenzoic acid, in particular by KBrO 3 in sulfuric acid, a conventional process which has been improved several times, or by Oxone®, consisting of 2KHSO 5 .KHSO 4 .K 2 SO, as described in J. Org. Chem. 1999, 64, 4537-4538. The authors of this recent article confirm that the IBX obtained is a crystalline, white solid, which even explodes very pure.
• the present invention relates to stabilized compositions of o-iodoxybenzoic acid which contain per 1 mole of o-iodoxybenzoic acid from 0.5 to 4 moles of a stabilizing agent chosen from
• n is between 8 and 20 and preferably equal to 14 or
• R represents H, CH 3 , COOH or their mixtures
• compositions in which there are from 1 to 2.5 moles of stabilizing agent per mole of o-iodoxybenzoic acid, and better still from 1.8 to 2.2 moles, in order to ensure maximum stabilization without increase costs excessively.
• acids of formula II preferred are benzoic, toluic, isophthalic and terephthalic acids, and among them of melting points above 200 C C such as isophthalic and terephthalic acid, temperature generally accepted as being that at which the IBX spontaneously explodes.
• mixtures of benzoic acid or o-toluic acid or one of their mixtures on the one hand and isophthalic acid or terephthalic acid or one of their mixtures on the other hand for good reason from 25 to 75% by mole of the monoacid in the mixture and better from 45 to 55% give stabilized compositions which do not explode under the action of an impact or heat.
• iodoxybenzoic acid compositions containing, as stabilizing agent, one or more compounds of formula II.
• compositions based on stabilizing agent of formula I it is preferable in the compositions based on stabilizing agent of formula I to also introduce an agent of formula II and preference is given to mixtures of a part of stearic or palmitic acid or of one of their mixtures, widely used acids , and on the other hand terephthalic acid or isophthalic acid or a mixture thereof, in an amount of 25 to 75 mol% of fatty acid in the mixture.
• the invention also relates to the process for preparing the compositions of the invention either from already isolated IBX or during the synthesis of IBX.
• a solution or suspension in water is made of the alkaline salts, particularly sodium, of the acids constituting the composition, and then acidified to total insolubilization of the composition.
• the stabilizing agents of formula I or II it is also possible to introduce a suitable quantity of one of the stabilizing agents of formula I or II, one of its alkaline salts or one of their mixtures into the medium in which the IBX is prepared, preferably in whole or partly from the start of the reaction, if the stabilizing agent is not broken down in this reaction medium.
• the stabilizing agent is a mixture, one of the constituents may be added during the reaction and the other before the isolation of the IBX.
• Those skilled in the art will be able, during a few preliminary tests, to determine the relative proportions of the stabilizing agent (s) and of the IBX as well as the modes of introduction of these agents, taking into account their possible reactivities and their relative solubilities in the media. reaction and precipitation.
• the concentration of IBX in the compositions obtained was determined by assay with sodium thiosulfate, iodine released during the oxidation of Kl by the IBX present in the composition (oxidimetric test).
• a composition is obtained which by heating gives a thick gray smoke but no orange flame.
• 10 g of stearic acid are added to a suspension of 10 g of IBX in 60 ml of water before introducing dropwise 8 ml of 10N aqueous NaOH solution to salify the acids.
• the heterogeneous medium is then acidified by adding 8 ml of an aqueous HCl solution at 33% before the isolation of the solid phase by filtration.
• the composition obtained after washing with 30 ml of water and drying does not explode with heat.
• Example 6 32 g of 2-iodobenzoic acid and 32 g of stearic acid are introduced into a solution of 1117 g of Oxone and 490 ml of water. After 2 hours at 70 ° C the medium is treated as above; the isolated composition generally does not explode with heat.
• the same proportions of reagents are used as in the previous example, but benzoic acid and isophthalic acid are not introduced until after oxidation during the cooling of the medium, around 35 ° C.
• the composition isolated by filtration is then homogenized. It is suspended in 4100 ml of water and 440 ml of aqueous 10N NaOH solution are added; the solution obtained at pH 7 is then acidified to 78 ° C by slow addition of 440 ml of an aqueous solution of hydrochloric acid at 33%.
• the composition isolated after filtration, washing with 500 ml of water and drying under vacuum contains 45%) by weight of IBX (oxydimetry). It is shock resistant and does not explode on heating.
• Example 8 The procedure is as in Example 8 but replacing the benzoic acid with a molar equivalent of stearic acid. A non-explosive composition is thus obtained which contains 38% by weight of IBX.
• Example 10 15 minutes, 30.6 g of the composition of Example 10 to a solution of 4.7 g of 3-pyridylmethanol in 70 ml of dimethylsulfoxide and the medium is stirred for 2 hours before pouring it onto 150 ml of and 60 ml of ethyl acetate. After neutralization of the aqueous phase and separation of the precipitate, the organic phase is separated and brought to dryness. 4.2 g of the expected 3-pyridyl carboxaldehyde are obtained (conformal NMR).
• menthone is obtained with L-menthol with 87% yield.

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• Oil, Petroleum & Natural Gas (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

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Citations (1)

• 2001
  • 2001-01-19 FR FR0100759A patent/FR2819808B1/fr not_active Expired - Fee Related
• 2002
  • 2002-01-17 ES ES02711994T patent/ES2240717T3/es not_active Expired - Lifetime
  • 2002-01-17 AT AT02711994T patent/ATE292613T1/de not_active IP Right Cessation
  • 2002-01-17 WO PCT/FR2002/000189 patent/WO2002057210A1/fr not_active Ceased
  • 2002-01-17 PT PT02711994T patent/PT1351917E/pt unknown
  • 2002-01-17 EP EP02711994A patent/EP1351917B1/fr not_active Expired - Lifetime
  • 2002-01-17 US US10/050,035 patent/US6462227B2/en not_active Expired - Lifetime
  • 2002-01-17 JP JP2002557892A patent/JP4332347B2/ja not_active Expired - Fee Related
  • 2002-01-17 DE DE60203595T patent/DE60203595T2/de not_active Expired - Lifetime

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