WO2002051376A2 - Compositions gommantes contenant des nanoparticules - Google Patents

Compositions gommantes contenant des nanoparticules Download PDF

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Publication number
WO2002051376A2
WO2002051376A2 PCT/EP2001/014649 EP0114649W WO02051376A2 WO 2002051376 A2 WO2002051376 A2 WO 2002051376A2 EP 0114649 W EP0114649 W EP 0114649W WO 02051376 A2 WO02051376 A2 WO 02051376A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition
skin
use according
particle size
average particle
Prior art date
Application number
PCT/EP2001/014649
Other languages
German (de)
English (en)
Other versions
WO2002051376A3 (fr
Inventor
Christian Kropf
Claudia Hundeiker
Marcel Roth
Soraya Heinen
Christian Umbreit
Original Assignee
Henkel Kommanditgesellschaft Auf Aktien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Kommanditgesellschaft Auf Aktien filed Critical Henkel Kommanditgesellschaft Auf Aktien
Priority to AU2002229654A priority Critical patent/AU2002229654A1/en
Publication of WO2002051376A2 publication Critical patent/WO2002051376A2/fr
Publication of WO2002051376A3 publication Critical patent/WO2002051376A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/28—Zirconium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • the invention relates to aqueous compositions for the abrasive treatment of the skin of the human body, in particular the face and / or the neck, which, in a cosmetically and / or dermatologically compatible carrier, contain a toxicologically acceptable, water-insoluble, nanoparticulate compound of an element from the second to fourth main group or the second, fourth or eighth subgroup of the Periodic Table of the Elements, the particles having an average particle size in the range from 10 to 1000 nm.
  • the compositions result in a thorough and gentle deep cleansing of the skin.
  • Aqueous surfactant solutions are usually used to clean the skin. However, stuck impurities, dead skin flakes, sebum secretions and make-up can only be removed incompletely.
  • abrasives While hand washing pastes with relatively coarse abrasives such as pumice powder, sea sand, sawdust or chalk are used for cleaning dirty hands, softer or finer ground abrasives are used for deep cleaning of sensitive skin, e.g. fine polymer powder, finely divided wax or triglyceride Powder and especially vegetable abrasives. Due to their emery effect, peeling compositions remove dead skin cells, massage the skin and ensure improved blood circulation. As abrasives, they usually contain oxidic materials or plastic particles, e.g. B. polyethylene particles or nylon particles, with particle sizes above 10 microns. Due to this relatively large particle size, however, only larger unevenness is removed, and burrs and flakes remain in the ⁇ m range.
  • oxidic materials or plastic particles e.g. B. polyethylene particles or nylon particles
  • JP-A 11049636 proposes skin cleansing and massage compositions containing molybdenum sulfate, tungsten sulfate, selenium-coated molybdenum and selenium-coated tungsten, in which these substances are in the form of particles with a size between 50 and 2000 nm.
  • these heavy metal compounds are not commercially available and, on the other hand, their use for cosmetic purposes is questionable for toxicological reasons, which applies in particular to the selenium-containing substances.
  • the invention therefore relates to the use of an aqueous composition which, in a cosmetically and / or dermatologically compatible carrier, contains a toxicologically acceptable, water-insoluble nanoparticulate compound of an element of the second to fourth main group or of the second, fourth or eighth subgroup of the periodic table of the elements with a contains average particle size in the range of 10 to 1000 nm, for the abrading treatment of the skin of the human body, especially the face and / or the neck.
  • the invention thus relates to compositions which are particularly useful in the cosmetic and / or dermatological field for massaging, deep cleansing and / or abrading treatment of the skin of the human body, in particular the face and / or the neck.
  • the compositions enable in particular the gentle removal of dead cells and impurities and unevenness of the skin and the opening of the skin pores.
  • composition can also contain several of the above-mentioned compounds or mixed compounds such as mixed oxides of two or more of the elements defined above. If the elements are metals, light metals (density below 5) and iron are preferred. Oxides, hydroxides, phosphates, silicates, carbonates and sulfates are preferred as compounds.
  • the average particle size of the nanoparticulate compounds is preferably in the range between 20 and 500 nm.
  • the size specifications are to be understood as diameters in the direction of the greatest longitudinal expansion of the particles; mean is the volume-weighted mean.
  • the size of nanoparticles always follows a distribution curve.
  • the method of dynamic light scattering known to the person skilled in the art can be used for the experimental determination of the particle size.
  • it is a compound of magnesium, calcium, aluminum, silicon, zinc, titanium, zirconium or iron, for example their oxides and silicates, insofar as they are sparingly soluble in water.
  • poor solubility in water means a solubility at 20 ° C. of less than 1% by weight, preferably less than 0.1% by weight, based on the total weight of the solution.
  • Zinc oxide, iron oxides, zirconium dioxide, aluminum oxide and aluminum oxide hydroxide are particularly preferred as nanoparticulate compounds.
  • nanoparticulate compounds suitable according to the invention are, for example, zinc oxide (Z-Cote from Sunsmart or Nanox from Rheox), magnesium silicate (Optigel SH from Süd-Chemie, Laponite XLG from Laporte), aluminum oxide (AI203 C from Fa Degussa) and aluminum oxide hydroxide (Boehmite from Condea).
  • zinc oxide Z-Cote from Sunsmart or Nanox from Rheox
  • magnesium silicate Optigel SH from Süd-Chemie, Laponite XLG from Laporte
  • aluminum oxide AI203 C from Fa Degussa
  • aluminum oxide hydroxide Boehmite from Condea
  • the nanoparticulate compounds are enveloped by one or more surface modification agents.
  • Surface modification is to be understood as covering the particle surface with organic compounds which interact with the surface of the particles via chemical bonds or physical forces.
  • Suitable surface modifiers for the nanoparticles are, for example, monobasic and polybasic carboxylic acids with 2 to 18 carbon atoms, hydroxycarboxylic acids, ether carboxylic acids, fruit acids and amino acids.
  • n SiR be used 4_ in which n is an integer between 1 and 3, R' is an alkyl radical having 1 to 4 carbon atoms and R is an organic hydrocarbon radical having 1 to 18 carbon atoms means where the radical R additionally contains a hydroxyl, carboxy, ester, amino, ammonium or epoxy group, quaternary ammonium compounds and amino acids are also suitable for surface modification.
  • surface modification agents are, for example, gelatin, starch, dextrin, dextran, pectin, gum arabic, casein, gums, polyvinyl alcohols, polyethylene glycols, polyvinyl pyrrolidone, polyvinyl butyrals, methyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose and surfactants and emulsifiers such as, for. B. fatty alcohol polyglycol ethers, fatty alcohol polyglycosides, fatty acid alkanolamides, glycerol esters, sorbitan esters or alkoxylated esters.
  • the nanoparticles are treated, for example, with a solution of 0.05 to 0.5 mol of the surface modification agent per mol of the nanoparticulate compound, preferably in water. This treatment is preferably carried out over a period of 1-24 hours at a temperature of at least 20 ° C., but preferably at 100 ° C.
  • the surface-modified nanoparticles are preferably isolated from the reaction mixture by dewatering.
  • the dispersion is preferably subjected to freeze drying.
  • Nanoparticles modified by this process preferably contain between 1 and 30% by weight, particularly preferably between 2 and 20% by weight, of the surface modification agent, based on the total weight of the surface-modified nanoparticles.
  • the optionally surface-modified nanoparticles are contained in an amount of 0.01 to 50 and preferably 0.1 to 15% by weight, based on the total weight of the compositions.
  • the nanoparticles used according to the invention it was found that even small skin flakes and superficial burrs and unevenness of the stratum corneum are removed by the nanoparticles used according to the invention, so that a smoother one Skin surface arises as with conventional peeling compositions. This cleanses and smoothes the skin very thoroughly and gives it an even, radiant appearance. In addition, the formation of new skin imperfections is prevented. Due to their small size, the nanoparticles do not cause an annoying granular, sandy or hard feeling when used. Another advantage is that they can be homogeneously distributed and stably dispersed in the compositions without any problems.
  • Nanoparticulate zinc oxide In the case of nanoparticulate zinc oxide, the nanoparticles not only act as a mild abrasive, but they also have an antibacterial and skin-calming effect that is effective directly at the same place of action, where the abrasive effect also takes place. Nanoparticulate zinc oxide therefore has a double function as a constituent of the compositions according to the invention and thus allows the formulation of particularly abrasive skin cleansers which are gentle on the skin. It is therefore particularly preferred for the purposes of the present invention.
  • compositions according to the invention can not only effectively remove small skin flakes and fine surface roughnesses of the skin, but also coarser particles and bumps in the order of magnitude of several ⁇ m, it is preferred if the compositions according to the invention additionally have one or more conventional ones in addition to the nanoparticulate compounds defined above Contain abrasives, which usually have an average particle size in the range of 10 to 500 microns.
  • Such conventional abrasives are, for example, chalk (calcite), aluminum oxide, aluminum oxide trihydrate, calcium phosphate dihydrate (CaHP0 4 2H 2 0), calcium pyrophosphate, insoluble sodium metaphosphate and silicas (precipitation and gel silicas), as well as polyethylene or polyamide Powder.
  • Herbal abrasives are e.g. B. the ground endocarp of apricot, peach, walnut or cherry kernels or the ground, possibly defatted pulp of almonds, coconuts, jojoba fruits, macadamia Nuts and other nuts.
  • Vegetable flours valued as mild abrasives are e.g. B. corn on the cob, wheat bran, oatmeal and wood flour.
  • the conventional abrasives defined above can be contained in the compositions according to the invention in an amount of 0.1 to 30% by weight, based on the total weight of the composition.
  • auxiliaries such as. B. thickeners, surfactants, fatty substances,
  • Preservatives pH adjusting agents or buffer salts, dyes, fragrances, glycols and polyols such as e.g. Glycerin, sorbitol or propylene glycol and optionally cosmetic or dermatological active ingredients, e.g. antimicrobial, sebosuppressive, anti-inflammatory (anti-inflammatory) agents, plant extracts, vitamins, proteins and protein derivatives.
  • active ingredients e.g. antimicrobial, sebosuppressive, anti-inflammatory (anti-inflammatory) agents, plant extracts, vitamins, proteins and protein derivatives.
  • B. guar cellulose derivatives, vegetable gums and microbial polysaccharides such as xanthan gum, inorganic substances such as. B. layered silicates, e.g. B. bentonite, montmorillonite, kaolin, talc and organically modified phyllosilicates, aluminosilicates and pyrogenic silicas.
  • synthetic organic thickeners can additionally z. B. water-soluble polyethylene oxides, polyurethanes, polyvinyl pyrrolidone,
  • Polyvinyl alcohol and polyacrylamides are used.
  • Anionic, zwitterionic, ampholytic and nonionic surfactants and mixtures thereof are suitable as surface-active substances.
  • the surfactants are preferably present in the compositions in amounts of 0.1-30% by weight.
  • Suitable surfactants are characterized by a preferably linear alkyl group or acyl group with 8-22 C atoms and a polar, ionic or nonionic grouping.
  • Examples of particularly suitable surface-active substances are, above all, the readily water-soluble anionic surfactants, such as those which produce foam in an aqueous medium.
  • alkyl sulfates and alkyl ether sulfates the alkyl (polyglycol ether) carboxylates
  • the alkyl sulfosuccinate salts alkane sulfonates, ⁇ -olefin sulfonates
  • the preparations according to the invention can be in the form of a lotion, a paste, a cream, a gel or another conventional form of application.
  • Flowable lotions with viscosities of 1-500 Pa s (20 ° C) or pastes with viscosities of more than 500 Pa s (20 ° C) are preferred. They can also contain emulsified oil or fat components or dispersed waxes or other meltable fat components to thicken and improve the skin cosmetic properties.
  • Preferred waxes are hydrogenated castor oil, particularly preferably in the form of nanoparticulate particles, optionally coated with a surfactant or emulsifier, as described, for example, in patent application DE 10059668.1.
  • the invention further relates to a method for cleaning and / or for the abrading treatment of the skin of the human body, in particular the face and / or the neck, which consists in applying a composition as defined above to the skin, the skin for removal of blemishes and imperfections is massaged with this composition, and then the skin is rinsed off, which is preferably done with water.
  • a zinc oxide paste was first produced by adding 81 g of nanoparticulate zinc oxide (Z-Cote from Sunsmart, average primary particle size smaller than 200 nm) and 19 g of Plantacare 1200 UP (C12-C16-alkyl polyglycoside) , 50% by weight of active substance in water) were intimately mixed in a laboratory kneader.
  • the average particle size in the paste was 280 nm.
  • a 1% by weight aqueous dispersion was prepared from the paste by stirring it into water. The measurement was carried out using the UPA 3.150 device from Microtrac.
  • phase 1 the constituents of phase 1 were first heated to 80 ° C. with stirring, held at 80 ° C. for about 2 minutes, and then cooled to about 35 ° C. with stirring.
  • ZnO paste and phase 2 water were then mixed and added to phase 1 with stirring.
  • Example 4 Peeling cream
  • the gel was adjusted to pH 5.5 with citric acid.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention concerne des compositions aqueuses utilisées pour effectuer un gommage de la peau du corps humain, en particulier du visage et/ou du cou. Ces compositions contiennent, dans un excipient cosmétiquement et/ou dermatologiquement acceptable, un composé nanoparticulaire toxicologiquement sans danger et difficilement soluble dans l'eau d'un élément du deuxième, troisième ou quatrième groupe principal ou du deuxième, quatrième ou huitième sous-groupe de la classification périodique des éléments, les particules présentant une taille moyenne comprise entre 10 et 1000 nm. Ces compositions permettent d'effectuer un nettoyage en profondeur de la peau efficace et non agressif.
PCT/EP2001/014649 2000-12-22 2001-12-13 Compositions gommantes contenant des nanoparticules WO2002051376A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002229654A AU2002229654A1 (en) 2000-12-22 2001-12-13 Nanoparticle-containing peeling compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064489.9 2000-12-22
DE2000164489 DE10064489A1 (de) 2000-12-22 2000-12-22 Nanopartikel enthaltende Peeling-Zusammensetzung

Publications (2)

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WO2002051376A2 true WO2002051376A2 (fr) 2002-07-04
WO2002051376A3 WO2002051376A3 (fr) 2003-08-21

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AU (1) AU2002229654A1 (fr)
DE (1) DE10064489A1 (fr)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080437A1 (fr) * 2003-03-14 2004-09-23 NanoOptec Ltd. Procede d'administration de substance par absorption transdermique, agent de pelage destine a etre utilise dans l'administration de substance par absorption transdermique, appareil de pelage et bande adhesive jetable pour appareil de pelage
EP1634565A1 (fr) * 2004-08-20 2006-03-15 Henkel Kommanditgesellschaft auf Aktien Composition exfoliante pour le corps
WO2007107258A1 (fr) * 2006-03-17 2007-09-27 Clariant International Ltd Agent cosmetique contenant du corindon nanoparticulaire
US8070079B2 (en) 2005-08-18 2011-12-06 Clariant Finance (Bvi) Limited Method for producing a silane modified surface nano-corundum
EP2371234B1 (fr) * 2010-04-05 2014-08-27 Rovcal, Inc. Revêtements pour appareil de soins personnels contenant du carbonate de calcium dérivé de coquilles de mollusques ou de perles

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10157541A1 (de) * 2001-11-23 2003-06-12 Beiersdorf Ag Hautreinigungszubereitung
DE10246160A1 (de) * 2002-10-02 2004-04-15 Beiersdorf Ag Mit Befeuchtungsmitteln getränkte Tücher, welche Zinkoxid einer Partikelgröße von 20 bis 100 mm enthalten
FR2870549B1 (fr) * 2004-05-24 2006-08-25 Financ Elysees Balzac Sa Non-tisse recurant, outil d'entretien incorporant dans sa structure ledit non-tisse recurant, fabrication

Citations (5)

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Publication number Priority date Publication date Assignee Title
US5139782A (en) * 1991-12-23 1992-08-18 Uop Facial cleansing mineral compositions
WO1993007855A1 (fr) * 1991-10-25 1993-04-29 The Boots Company Plc Composition de toilette
WO1999045901A1 (fr) * 1998-03-13 1999-09-16 Color Access, Inc. Utilisation de la tourmaline dans des compositions cosmetiques de nettoyage
WO2000054733A2 (fr) * 1999-03-12 2000-09-21 Henkel Kommanditgesellschaft Auf Aktien Supports souples et absorbants, pourvus de dispersions de nanoparticules, pour le traitement de la peau
EP1174122A1 (fr) * 2000-07-13 2002-01-23 L'oreal Composition cosmétique de nettoyage

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US4992476A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Skin cleansing and moisturizing composition and method of using and preparing same
US5512277A (en) * 1991-05-15 1996-04-30 Kao Corporation Keratotic plug remover
JP3629339B2 (ja) * 1996-07-30 2005-03-16 花王株式会社 洗浄剤組成物
JP3641697B2 (ja) * 1997-08-07 2005-04-27 株式会社ノエビア 皮膚マッサージ用及び清浄化用外用剤

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Publication number Priority date Publication date Assignee Title
WO1993007855A1 (fr) * 1991-10-25 1993-04-29 The Boots Company Plc Composition de toilette
US5139782A (en) * 1991-12-23 1992-08-18 Uop Facial cleansing mineral compositions
WO1999045901A1 (fr) * 1998-03-13 1999-09-16 Color Access, Inc. Utilisation de la tourmaline dans des compositions cosmetiques de nettoyage
WO2000054733A2 (fr) * 1999-03-12 2000-09-21 Henkel Kommanditgesellschaft Auf Aktien Supports souples et absorbants, pourvus de dispersions de nanoparticules, pour le traitement de la peau
EP1174122A1 (fr) * 2000-07-13 2002-01-23 L'oreal Composition cosmétique de nettoyage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YAMAZAKI, RITSUKO ET AL: "Skin cleanser compositions containing nonionic surfactants and water-swellable clay minerals" retrieved from STN Database accession no. 128:158747 XP002202925 & JP 10 045565 A (KAO CORP., JAPAN) 17. Februar 1998 (1998-02-17) *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 05, 31. Mai 1999 (1999-05-31) & JP 11 049636 A (NOEVIR CO LTD), 23. Februar 1999 (1999-02-23) in der Anmeldung erwähnt *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080437A1 (fr) * 2003-03-14 2004-09-23 NanoOptec Ltd. Procede d'administration de substance par absorption transdermique, agent de pelage destine a etre utilise dans l'administration de substance par absorption transdermique, appareil de pelage et bande adhesive jetable pour appareil de pelage
EP1634565A1 (fr) * 2004-08-20 2006-03-15 Henkel Kommanditgesellschaft auf Aktien Composition exfoliante pour le corps
US8070079B2 (en) 2005-08-18 2011-12-06 Clariant Finance (Bvi) Limited Method for producing a silane modified surface nano-corundum
WO2007107258A1 (fr) * 2006-03-17 2007-09-27 Clariant International Ltd Agent cosmetique contenant du corindon nanoparticulaire
EP2371234B1 (fr) * 2010-04-05 2014-08-27 Rovcal, Inc. Revêtements pour appareil de soins personnels contenant du carbonate de calcium dérivé de coquilles de mollusques ou de perles

Also Published As

Publication number Publication date
AU2002229654A1 (en) 2002-07-08
DE10064489A1 (de) 2002-07-11
WO2002051376A3 (fr) 2003-08-21

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