Classifications

• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
  • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
  • A23L33/29—Mineral substances, e.g. mineral oils or clays
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
  • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
  • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
  • A23L33/24—Cellulose or derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/02—Nutrients, e.g. vitamins, minerals
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/04—Anorexiants; Antiobesity agents

Definitions

• the present invention relates to an agent for oral administration to produce a long-lasting satiety effect, comprising at least one substance which increases the viscosity of a liquid and at least one further compound which increases the residence time of the viscosity-increasing substance in the stomach.
• Preparations with gel-forming substances that develop their long-lasting, satiating effect via the gastrointestinal tract in the form of tablets, granules, suspensions or solutions are used for treatment, e.g. B. from overweight and diseases caused by obesity.
• Appropriate preparations contain herbal mucilage and swelling agents, such as. B. alginates, pectin, wheat bran, starch gels or guar flour. With an ingestion fluid together or in the presence of gastric fluid, these substances form a gel-like structure, so-called hydrode or hydrocolloids, which among other things. can serve the saturation.
• the present invention relates to an agent for oral administration to produce a long-lasting satiety effect, comprising at least one substance which increases the viscosity of a liquid and at least one further compound which increases the residence time of the viscosity-increasing substance to prolong a satiety effect in the stomach.
• fatty acids and / or fatty acid derivatives are added as a further compound to the substances used to form gel or pulp or to increase the viscosity of liquids.
• Fatty acids and / or fatty acid derivatives lead to a slowdown in gastric emptying and thus to the desired increased gastric dwell time.
• the agents according to the invention do not contain any drugs that have a systemic, pharmacological effect. Drugs which have a systemic, pharmacological effect are understood to mean those drugs which, after absorption, are distributed in the blood stream and thus reach the site of action.
• the agents according to the invention are further characterized in that they contain fatty acids with at least 6 carbon atoms in the molecule, their salts and / or derivatives thereof. According to the invention, these can be saturated and / or unsaturated fatty acids.
• the agent according to the invention can contain fatty acids with a carbon chain of length in the range from do to C 2 o, preferably C-12 to Cis, particularly preferably C 13 to C 16 .
• fatty acids is mentioned here as an example, but these are not limiting for the present invention.
• Salts and / or derivatives of the fatty acids are also included according to the invention. These can be, for example, alkali and / or ammonium salts and / or various fatty acid esters. Examples include glycerol esters such as. B. fats in which the fatty acids can be bound. Furthermore, the fatty acids can be chemically bound in lecithin and released by enzymatic processes during digestion in the gastrointestinal tract, in order subsequently to bring about the desired function of extending the residence time of the agent according to the invention.
• the fatty acids can be incorporated into the agent according to the invention in finely dispersed form by trituration with colloidal silica.
• the solubility of the fatty acids in the agent according to the invention is improved.
• the agent according to the invention can contain fatty acids in a proportion of 0.7 to 70 mg / g, preferably 2.5 to 50 mg / g and particularly preferably 10 to 20 mg / g of viscosity-increasing substance.
• a viscosity-increasing substance is to be understood as a mostly organic and high-molecular substance
• gels are to be understood as meaning dimensionally stable, easily deformable systems which result from the interaction of high-molecular substances with liquids.
• the substances referred to as gel formers form three-dimensional networks in which liquid molecules (dispersants) are incorporated. If the dispersant is a liquid, one speaks of lyogels; if it is water, the gels are called hydrogels.
• the gels have no firm connections between the cavities filled with liquid or gas, as is the case with sponges or sponge-like structures.
• the agent for achieving a long-lasting saturation effect contains, in addition to the aforementioned fatty acids, their salts and / or derivatives as a viscosity-increasing substance, natural, synthetic and / or semi-synthetic polysaccharides and / or polyacids and / or mixtures thereof.
• Examples of this are well known, e.g. B. agar-agar, alginic acid, alginates, laminarin, fucoidin, lentinan, schitophyllan, acacia gum, carrageenan, guar gum, St. John's wort, galactomannans, tragacanth, hyaluronic acid, althea mucus, quince mucus, psyllium mucus, xanthanymethyl cellulose , Pectins, dextrans, dextrin, cellulose, acacia, gelatin, soy, starch and / or their derivatives and / or mixtures thereof.
• Preferred embodiments of the agent according to the invention contain guar gum and / or methyl cellulose and / or starch derivatives.
• guar gallactomannan is particularly preferred and / or guar gum and / or hydroxymethyl cellulose
• Carboxymethyl cellulose and / or hydroxyethyl starch and / or mixtures of the aforementioned substances are particularly useful as carboxymethyl cellulose and / or hydroxyethyl starch and / or mixtures of the aforementioned substances.
• the agent is in the form of a powder, granules, compressed, pellet, tablet, capsule, solution, dispersion, slurry and / or any other suitable formulation.
• the agent can be dissolved and / or dispersed in a hydrophilic or lipophilic medium.
• Media which are particularly suitable according to the invention are water, milk drinks, fruit juices and / or oil.
• the preparation can be carried out by stirring the agent according to the invention into these liquids and / or can be processed into a slurry by heating.
• the agent according to the invention can contain gas-forming substances.
• these gas-generating substances can support the formation of a gel.
• the agent according to the invention can contain shower mixtures.
• the shower mix can preferably be flavored.
• the present invention also relates to the use of a previously mentioned agent as an additive to foods, for the production of nutritional supplements, appetite suppressants and / or
• Food are used, but also before, during and / or after eating food and so one longer residence time of the food combined with a long-lasting satiety effect in the stomach.
• the C- ⁇ 4 fatty acid is finely rubbed with the colloidal silica and then sieved (mesh size 0.3 mm).
• the trituration of the fatty acid with the colloidal silica is mixed with the guar flour. This is then followed by granulation with purified water. The granules are dried at 45 ° C.
• the fatty acids are triturated homogeneously with the table salt and colloidal silica.
• 3 to 6 g of the granules described in Preparation 1 are distributed in 150 ml of multivitamin juice with stirring.
• the suspension of the granules is drunk in the multivitamin juice within the first minute after being added.
• the feeling of satiety lasts for about 2 to 3 hours.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Nutrition Science (AREA)
• Mycology (AREA)
• Polymers & Plastics (AREA)
• Food Science & Technology (AREA)
• General Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Medicinal Chemistry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• General Health & Medical Sciences (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Animal Behavior & Ethology (AREA)
• Pharmacology & Pharmacy (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Obesity (AREA)
• Hematology (AREA)
• Diabetes (AREA)
• Dispersion Chemistry (AREA)
• Child & Adolescent Psychology (AREA)
• Medicinal Preparation (AREA)
• Coloring Foods And Improving Nutritive Qualities (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Priority Applications (4)

Applications Claiming Priority (2)

Publications (2)

Family

ID=7655784

Family Applications (1)

Country Status (7)

Cited By (2)

Families Citing this family (5)

Family Cites Families (3)

• 2000
  • 2000-09-11 DE DE10044846A patent/DE10044846A1/de not_active Ceased
• 2001
  • 2001-09-07 EP EP01978347A patent/EP1322182A2/de not_active Withdrawn
  • 2001-09-07 US US10/363,090 patent/US20030161885A1/en not_active Abandoned
  • 2001-09-07 WO PCT/EP2001/010309 patent/WO2002019842A2/de not_active Ceased
  • 2001-09-07 AU AU2002210491A patent/AU2002210491A1/en not_active Abandoned
  • 2001-09-07 JP JP2002524334A patent/JP2004508310A/ja active Pending
  • 2001-09-07 CA CA002419389A patent/CA2419389A1/en not_active Abandoned

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