WO2002002531A1 - Spirobenzoazepines non peptidiques substituees, antagonistes de la vasopressine - Google Patents

Spirobenzoazepines non peptidiques substituees, antagonistes de la vasopressine Download PDF

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Publication number
WO2002002531A1
WO2002002531A1 PCT/US2001/021080 US0121080W WO0202531A1 WO 2002002531 A1 WO2002002531 A1 WO 2002002531A1 US 0121080 W US0121080 W US 0121080W WO 0202531 A1 WO0202531 A1 WO 0202531A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
alkyl
compound
spiro
phenyl
Prior art date
Application number
PCT/US2001/021080
Other languages
English (en)
Inventor
Robert H. Chen
Min A. Xiang
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2413945A priority Critical patent/CA2413945C/fr
Priority to EP01950821A priority patent/EP1307430B1/fr
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Priority to MXPA03000135A priority patent/MXPA03000135A/es
Priority to AT01950821T priority patent/ATE305454T1/de
Priority to DE60113696T priority patent/DE60113696T2/de
Priority to AU2001271780A priority patent/AU2001271780B2/en
Priority to NZ523450A priority patent/NZ523450A/en
Priority to CN018149278A priority patent/CN1449386B/zh
Priority to JP2002507788A priority patent/JP4916639B2/ja
Priority to AU7178001A priority patent/AU7178001A/xx
Priority to BR0112372-6A priority patent/BR0112372A/pt
Priority to IL15371001A priority patent/IL153710A0/xx
Priority to HU0301590A priority patent/HUP0301590A3/hu
Publication of WO2002002531A1 publication Critical patent/WO2002002531A1/fr
Priority to IL153710A priority patent/IL153710A/en
Priority to NO20030028A priority patent/NO324499B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

L'invention porte sur des spirobenzoazepines non peptidiques substituées, antagonistes de la vasopressine, de formule générale (i) dans laquelle: A, X, n, R1, R2, R3, R4, R5, a et b sont définis dans la description, et qui s'avèrent d'utiles antagonistes du récepteur de la vasopressine pour le traitement de troubles liés à l'activité dudit récepteur dont ceux impliquant un accroissement de la résistance vasculaire, et l'insuffisance cardiaque. L'invention porte également sur des compositions pharmaceutiques comprenant un composé de formule (I), et sur des procédés de traitement d'affections telles que l'hypertension, l'insuffisance cardiaque congestive, l'insuffisance cardiaque, l'angiospasme coronarien, l'ischémie cardiaque, la cirrhose du foie, l'angiospasme du rein, l'oedème cérébral, l'ischémie cérébrale, les attaques, les thromboses ou la rétention d'eau.
PCT/US2001/021080 2000-07-05 2001-07-02 Spirobenzoazepines non peptidiques substituees, antagonistes de la vasopressine WO2002002531A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP2002507788A JP4916639B2 (ja) 2000-07-05 2001-07-02 バソプレシン拮抗質としての非ペプチド系置換スピロベンゾアゼピン
CN018149278A CN1449386B (zh) 2000-07-05 2001-07-02 作为血管升压素拮抗剂的非肽取代的螺苯并氮杂*
MXPA03000135A MXPA03000135A (es) 2000-07-05 2001-07-02 Espirobenzoazepinas sustitudas no peptidicas como antagonistas de vasopresina.
EP01950821A EP1307430B1 (fr) 2000-07-05 2001-07-02 Spirobenzoazepines non peptidiques substituees, antagonistes de la vasopressine
DE60113696T DE60113696T2 (de) 2000-07-05 2001-07-02 Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten
AU2001271780A AU2001271780B2 (en) 2000-07-05 2001-07-02 Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
AU7178001A AU7178001A (en) 2000-07-05 2001-07-02 Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
CA2413945A CA2413945C (fr) 2000-07-05 2001-07-02 Spirobenzoazepines non peptidiques substituees, antagonistes de la vasopressine
AT01950821T ATE305454T1 (de) 2000-07-05 2001-07-02 Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten
NZ523450A NZ523450A (en) 2000-07-05 2001-07-02 Nonpeptide substituted spirobenzoazepines as vasopressin receptor antagonists
BR0112372-6A BR0112372A (pt) 2000-07-05 2001-07-02 Espirobenzoazepinas substituìdas por não-peptìdeo como antagonistas de vasopressina
IL15371001A IL153710A0 (en) 2000-07-05 2001-07-02 Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
HU0301590A HUP0301590A3 (en) 2000-07-05 2001-07-02 Nonpeptide substituted spirobenzoazepines as vasopressin antagonists, pharmaceutical compositions containing them and their preparation
IL153710A IL153710A (en) 2000-07-05 2002-12-27 Nonpeptide substituted spirobenzoazepines as vasopressin antagonists and pharmaceutical compositions comprising the same
NO20030028A NO324499B1 (no) 2000-07-05 2003-01-03 Ikke-peptidsubstituerte spirobenzoazepiner som vasopressinantagonister

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21622000P 2000-07-05 2000-07-05
US60/216,220 2000-07-05

Publications (1)

Publication Number Publication Date
WO2002002531A1 true WO2002002531A1 (fr) 2002-01-10

Family

ID=22806231

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021080 WO2002002531A1 (fr) 2000-07-05 2001-07-02 Spirobenzoazepines non peptidiques substituees, antagonistes de la vasopressine

Country Status (20)

Country Link
US (4) US7001898B2 (fr)
EP (1) EP1307430B1 (fr)
JP (1) JP4916639B2 (fr)
CN (1) CN1449386B (fr)
AT (1) ATE305454T1 (fr)
AU (2) AU2001271780B2 (fr)
BR (1) BR0112372A (fr)
CA (1) CA2413945C (fr)
DE (1) DE60113696T2 (fr)
DK (1) DK1307430T3 (fr)
ES (1) ES2250432T3 (fr)
HU (1) HUP0301590A3 (fr)
IL (2) IL153710A0 (fr)
MX (1) MXPA03000135A (fr)
MY (1) MY135101A (fr)
NO (1) NO324499B1 (fr)
NZ (1) NZ523450A (fr)
TW (1) TWI316057B (fr)
WO (1) WO2002002531A1 (fr)
ZA (1) ZA200300972B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1364968A1 (fr) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostic et traitement des maladies associées au récepteur 1 d'arginine-vasopressine (AVPR1)
WO2005000819A1 (fr) * 2003-06-17 2005-01-06 Janssen Pharmaceutica N.V. Processus de preparation de derives de spirobenzoazepine substitues non peptidiques
WO2005037795A2 (fr) * 2003-06-17 2005-04-28 Janssen Pharmaceutica N.V. Spirobenzazepines substituees
WO2008036755A1 (fr) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spirobenzazépines utilisées en tant qu'antagonistes de vasopressine
WO2008036759A1 (fr) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spirobenzazépines utilisées en tant qu'antagonistes de vasopressine
WO2008154347A1 (fr) * 2007-06-06 2008-12-18 Janssen Pharmaceutica N.V. Spirobenzoazépine en tant qu'antagonistes de vasopressine
US7691844B2 (en) 2000-07-05 2010-04-06 Ortho-Mcneil Pharmaceutical, Inc. Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
WO2019116324A1 (fr) 2017-12-15 2019-06-20 Richter Gedeon Nyrt. Triazolobenzazépines utilisées en tant qu'antagonistes du récepteur de la vasopressine v1a
WO2019116325A1 (fr) 2017-12-15 2019-06-20 Richter Gedeon Nyrt. Composés tricycliques utilisés en tant qu'antagonistes du récepteur de la vasopressine v1a

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1984342A2 (fr) * 2006-01-20 2008-10-29 Janssen Pharmaceutica, N.V. Formes solides atypiques d acide carboxylique (4r)-1-[4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl]-1,2,3,5-tetrahydro-spiro[4h-1-benzazepine-4,1'-[2]cyclopentene]-3'
BRPI0920330A2 (pt) * 2008-10-10 2016-02-23 Janssen Pharmaceutica Nv terapia de combinação que compreende bloqueadores do receptor da angiotensina e antagonistas do receptor da vasopressina
EP4253367A1 (fr) * 2020-11-26 2023-10-04 Shanghai Jemincare Pharmaceuticals Co., Ltd. Nouveau dérivé spiro de benzazépine
CN112939864B (zh) * 2021-01-29 2022-05-06 中国医科大学 螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物

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EP0640592A1 (fr) * 1993-07-29 1995-03-01 American Cyanamid Company Azahétérocycles tricycliques n-acylés utiles comme antagonistes de vasopressine
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WO1999037637A1 (fr) * 1998-01-27 1999-07-29 Fujisawa Pharmaceutical Co., Ltd. Derives de benzamide antagonistes vis-a-vis de la vasopressine

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005549A1 (fr) * 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Composes benzoheterocycliques
WO1994007496A1 (fr) * 1992-10-07 1994-04-14 Merck & Co., Inc. Antagonistes recepteurs d'oxytocine tocolytique
EP0640592A1 (fr) * 1993-07-29 1995-03-01 American Cyanamid Company Azahétérocycles tricycliques n-acylés utiles comme antagonistes de vasopressine
EP0636608A1 (fr) * 1993-07-30 1995-02-01 Sanofi Dérivés du 1-benzènesulfonyl-1,3-dihydro-indol-2-one, leur préparation, les compositions pharmaceutiques en contenant
WO1995025443A1 (fr) * 1994-03-24 1995-09-28 Merck & Co., Inc. Antagonistes tocolytique des recepteurs de l'ocytocine
WO1997049707A1 (fr) * 1996-06-27 1997-12-31 American Cyanamid Company Les benzazepines: des antagonistes tricycliques de la vasopressine
WO1999037637A1 (fr) * 1998-01-27 1999-07-29 Fujisawa Pharmaceutical Co., Ltd. Derives de benzamide antagonistes vis-a-vis de la vasopressine

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7691844B2 (en) 2000-07-05 2010-04-06 Ortho-Mcneil Pharmaceutical, Inc. Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
EP1364968A1 (fr) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostic et traitement des maladies associées au récepteur 1 d'arginine-vasopressine (AVPR1)
WO2003099867A1 (fr) * 2002-05-23 2003-12-04 Bayer Healthcare Ag Agents de diagnostic et de therapie pour des maladies associees au recepteur 1 de l'arginine vasopressine (avpr1)
AU2004281257B2 (en) * 2003-06-17 2010-02-04 Janssen Pharmaceutica N.V. Substituted spirobenzazepines
KR101086246B1 (ko) 2003-06-17 2011-11-23 얀센 파마슈티카 엔.브이. 치환된 스피로벤즈아제핀
JP2007521272A (ja) * 2003-06-17 2007-08-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 置換スピロベンズアゼピン
WO2005037795A3 (fr) * 2003-06-17 2005-07-28 Janssen Pharmaceutica Nv Spirobenzazepines substituees
AU2004281257C1 (en) * 2003-06-17 2010-07-01 Janssen Pharmaceutica N.V. Substituted spirobenzazepines
WO2005000819A1 (fr) * 2003-06-17 2005-01-06 Janssen Pharmaceutica N.V. Processus de preparation de derives de spirobenzoazepine substitues non peptidiques
EA011089B1 (ru) * 2003-06-17 2008-12-30 Янссен Фармацевтика Н.В. Замещённые спиробензазепины
WO2005037795A2 (fr) * 2003-06-17 2005-04-28 Janssen Pharmaceutica N.V. Spirobenzazepines substituees
US7687494B2 (en) 2003-06-17 2010-03-30 Janssen Pharmaceutica Nv Substituted spirobenzazepines
WO2008036759A1 (fr) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spirobenzazépines utilisées en tant qu'antagonistes de vasopressine
US7825110B2 (en) 2006-09-22 2010-11-02 Janssen Pharmaceutica Nv Substituted spiroheterocycles
US7825111B2 (en) 2006-09-22 2010-11-02 Janssen Pharmaceutica Nv Substituted spiroheterocycles
WO2008036755A1 (fr) * 2006-09-22 2008-03-27 Janssen Pharmaceutica N.V. Spirobenzazépines utilisées en tant qu'antagonistes de vasopressine
AU2007299818B2 (en) * 2006-09-22 2012-08-02 Janssen Pharmaceutica N.V. Spiro benzazepines used as vasopressin antagonists
WO2008154347A1 (fr) * 2007-06-06 2008-12-18 Janssen Pharmaceutica N.V. Spirobenzoazépine en tant qu'antagonistes de vasopressine
WO2019116324A1 (fr) 2017-12-15 2019-06-20 Richter Gedeon Nyrt. Triazolobenzazépines utilisées en tant qu'antagonistes du récepteur de la vasopressine v1a
WO2019116325A1 (fr) 2017-12-15 2019-06-20 Richter Gedeon Nyrt. Composés tricycliques utilisés en tant qu'antagonistes du récepteur de la vasopressine v1a
US11298363B2 (en) 2017-12-15 2022-04-12 Richter Gedeon Nyrt. Triazolobenzazepines as vasopressin V1a receptor antagonists

Also Published As

Publication number Publication date
ES2250432T3 (es) 2006-04-16
CN1449386B (zh) 2012-07-04
JP4916639B2 (ja) 2012-04-18
TWI316057B (en) 2009-10-21
ATE305454T1 (de) 2005-10-15
EP1307430B1 (fr) 2005-09-28
JP2004502677A (ja) 2004-01-29
IL153710A (en) 2010-12-30
IL153710A0 (en) 2003-07-06
US7238687B2 (en) 2007-07-03
US20060111567A1 (en) 2006-05-25
DE60113696T2 (de) 2006-07-13
NO324499B1 (no) 2007-10-29
BR0112372A (pt) 2003-07-22
AU2001271780B2 (en) 2006-09-14
US20030045517A1 (en) 2003-03-06
US7691844B2 (en) 2010-04-06
CA2413945A1 (fr) 2002-01-10
NO20030028D0 (no) 2003-01-03
MY135101A (en) 2008-02-29
NZ523450A (en) 2004-11-26
EP1307430A1 (fr) 2003-05-07
DK1307430T3 (da) 2006-01-30
HUP0301590A2 (hu) 2003-09-29
CA2413945C (fr) 2011-05-17
MXPA03000135A (es) 2005-02-17
US7365062B2 (en) 2008-04-29
AU7178001A (en) 2002-01-14
US20070117790A1 (en) 2007-05-24
CN1449386A (zh) 2003-10-15
NO20030028L (no) 2003-03-03
HUP0301590A3 (en) 2005-01-28
US7001898B2 (en) 2006-02-21
ZA200300972B (en) 2004-05-04
DE60113696D1 (de) 2006-02-09
US20070135409A1 (en) 2007-06-14

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