WO2001018526A1 - Improved method and apparatus for aspirating and dispensing liquids - Google Patents

Improved method and apparatus for aspirating and dispensing liquids Download PDF

Info

Publication number
WO2001018526A1
WO2001018526A1 PCT/US2000/023188 US0023188W WO0118526A1 WO 2001018526 A1 WO2001018526 A1 WO 2001018526A1 US 0023188 W US0023188 W US 0023188W WO 0118526 A1 WO0118526 A1 WO 0118526A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
aspiration
probe
container
aspiration probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/023188
Other languages
English (en)
French (fr)
Inventor
Imran T. Siddiqui
Roberto Del Valle
Santos Vargas
Pedro P. Cabrera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Coulter International Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter International Corp filed Critical Coulter International Corp
Priority to EP00957737A priority Critical patent/EP1210575B1/en
Priority to JP2001522065A priority patent/JP4570120B2/ja
Priority to DE60043891T priority patent/DE60043891D1/de
Publication of WO2001018526A1 publication Critical patent/WO2001018526A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the LCU Upon venting the container, the LCU operates to reverse the state of double-acting pinch valve 90, thereby obstructing fluid communication between vent 95 and the sealed container, and permitting fluid communication between the vacuum pump 40 and the sealed container. Pinch valves 60 and 70 remain OPEN, and pinch valve 80 remains CLOSED. See FIG. 3.
  • the LCU Upon receiving a signal from level sensor 102 indicating that the probe tip is below the level of the contained liquid, the LCU activates vacuum pump 40 to begin aspiration of blood B through the aspirating probe; aspiration occurs, of course, as a result of the negative pressure within the probe provided by vacuum pump 40 applied through conduits 125, 126, 128, 120 and 115.
  • Purging After the liquid within the probe has been dispensed and, if desired, diluted, it is desirable to purge any traces of the metered liquid and the remaining diluent present within the interior of the probe so as to prevent contamination of the succeeding aspirated sample. To accomplish this purging, the aspiration probe is removed from the workstation and exposed to ambient air. Then, referring to FIG.
  • FIG. 9 illustrates a variation of the aforedescribed apparatus in which multiple aspiration probes P1-P4 are coupled in the manner described to a single shear valve V.
  • This arrangement allows for the simultaneous aspiration of sample from multiple sample containers C1-C4, thereby increasing the throughput of the apparatus.
  • the aspiration probes can have different internal volumes, all aspirating simultaneously from the same (or different) container(s) and each dispensing a different volume defined by its unique internal volume.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
PCT/US2000/023188 1999-09-08 2000-08-23 Improved method and apparatus for aspirating and dispensing liquids Ceased WO2001018526A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00957737A EP1210575B1 (en) 1999-09-08 2000-08-23 Improved method and apparatus for aspirating and dispensing liquids
JP2001522065A JP4570120B2 (ja) 1999-09-08 2000-08-23 液体を吸引及び分配するための改良された方法及び装置
DE60043891T DE60043891D1 (de) 1999-09-08 2000-08-23 Verbessertes verfahren und vorrichtung zum ansaugen und verteilen von flüssigkeiten

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/392,161 US6322752B1 (en) 1999-09-08 1999-09-08 Method and apparatus for aspirating and dispensing liquids
US09/392,161 1999-09-08

Publications (1)

Publication Number Publication Date
WO2001018526A1 true WO2001018526A1 (en) 2001-03-15

Family

ID=23549502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023188 Ceased WO2001018526A1 (en) 1999-09-08 2000-08-23 Improved method and apparatus for aspirating and dispensing liquids

Country Status (5)

Country Link
US (1) US6322752B1 (enExample)
EP (1) EP1210575B1 (enExample)
JP (1) JP4570120B2 (enExample)
DE (1) DE60043891D1 (enExample)
WO (1) WO2001018526A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4076048B2 (ja) * 2000-09-22 2008-04-16 富士フイルム株式会社 定量吸引装置
US7135146B2 (en) * 2000-10-11 2006-11-14 Innovadyne Technologies, Inc. Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device
US6852291B1 (en) * 2000-10-11 2005-02-08 Innovadyne Technologies, Inc. Hybrid valve apparatus and method for fluid handling
US6861034B1 (en) * 2000-11-22 2005-03-01 Xerox Corporation Priming mechanisms for drop ejection devices
US20020106804A1 (en) * 2001-02-05 2002-08-08 Nippon Laser & Electronics Lab Method for analyzing reaction test sample using test sample chip
WO2002089670A1 (en) * 2001-05-10 2002-11-14 Chempaq A/S Device for sampling small and precise volumes of liquid
US6872361B2 (en) * 2001-06-28 2005-03-29 Coulter International Corp. Dual pad liquid shear valve assembly
US6983636B2 (en) 2002-01-25 2006-01-10 Innovadyne Technologies, Inc. Apparatus and method for assessing the liquid flow performances through a small dispensing orifice
US6908226B2 (en) * 2003-02-07 2005-06-21 Beckman Coulter, Inc. Method and apparatus for aspirating liquid from a container
US7396512B2 (en) 2003-11-04 2008-07-08 Drummond Scientific Company Automatic precision non-contact open-loop fluid dispensing
JP4095968B2 (ja) * 2004-02-06 2008-06-04 株式会社日立ハイテクノロジーズ 液体分注装置、それを用いた自動分析装置、及び液面検出装置
US7621282B2 (en) * 2004-06-17 2009-11-24 Abbott Laboratories, Inc. Probe washing cups and methods
US7205158B2 (en) * 2004-06-18 2007-04-17 Dade Behring Inc. Method for aspiration of a liquid sample
US7481978B2 (en) * 2005-03-23 2009-01-27 Beckman Coulter, Inc. Apparatus for aspirating liquids from sealed containers
US20060258011A1 (en) * 2005-04-22 2006-11-16 Igor Shvets Cleaning of system for dispensing of liquid droplets
AU2006244476B2 (en) 2005-05-06 2011-09-29 Instrumentation Laboratory Company Telescoping closed-tube sampling assembly
US7618590B2 (en) * 2005-06-29 2009-11-17 Cascade Microtech, Inc. Fluid dispensing system
WO2007091654A1 (ja) * 2006-02-09 2007-08-16 Arkray, Inc. 液体クロマトグラフィ装置
JP2008058163A (ja) * 2006-08-31 2008-03-13 Hitachi High-Technologies Corp 自動分析装置
US7661326B2 (en) * 2006-10-26 2010-02-16 Beckman Coulter, Inc. Apparatus for aspirating and dispensing liquids in an automated analyzer
WO2008115815A1 (en) * 2007-03-16 2008-09-25 Tricontinent Scientific Syringe barrel wiper for liquid dispensing
JP2009025249A (ja) * 2007-07-23 2009-02-05 Olympus Corp 分注装置および自動分析装置
JP5162177B2 (ja) * 2007-07-31 2013-03-13 シスメックス株式会社 粒子分析装置及び粒子分析方法
US8726745B2 (en) * 2007-11-26 2014-05-20 Perkinelmer Health Sciences, Inc. Fluid handling device with ultrasound sensor and methods and systems using same
US8118042B2 (en) * 2008-02-29 2012-02-21 Beckman Coulter, Inc. Apparatus and method for cleaning a liquid handling probe
CH703127A1 (de) * 2010-05-12 2011-11-15 Tecan Trading Ag Dispenser und Verfahren zum Abgeben von fliess- oder rieselfähigen Materialien.
JP6003212B2 (ja) * 2012-05-17 2016-10-05 ソニー株式会社 サンプル送液装置、フローサイトメータ及びサンプルチューブ判定方法
US9909945B2 (en) 2012-10-04 2018-03-06 Siemens Healthcare Diagnostics Inc. Methods and apparatus for measuring aspiration pressure at low aspiration volumes
US9989551B2 (en) 2013-02-15 2018-06-05 Siemens Healthcare Diagnostics Inc. Real-time volume confirmation dispensing apparatus and methods
JP6220575B2 (ja) * 2013-06-27 2017-10-25 シスメックス株式会社 試料処理装置および試料処理装置の異常検出方法
WO2015092844A1 (ja) * 2013-12-16 2015-06-25 株式会社島津製作所 液採取装置及びその液採取装置を備えた自動分析装置
JP6230450B2 (ja) * 2014-03-10 2017-11-15 株式会社日立ハイテクノロジーズ 分注装置及び分注方法
JP5808473B2 (ja) * 2014-10-29 2015-11-10 株式会社東芝 自動分析装置
PL3283801T3 (pl) * 2015-04-14 2021-03-22 Keofitt A/S Urządzenie pobierające próbki do pobierania próbek płynu z pojemnika na płyn
HUE047612T2 (hu) * 2016-05-11 2020-05-28 Diatron Mi Zrt Eszköz folyadékok nagy pontosságú mintavételezésére automatizált mintaelemzõ berendezésben
DE102017008037B4 (de) * 2017-08-24 2021-05-12 Karl-Heinz Walz Tiefentnahmegerät für Flüssigkeitsproben
US12420276B2 (en) 2017-12-19 2025-09-23 Siemens Healthcare Diagnostics Inc. Probe apparatus, assemblies, and methods for aspirating and dispensing liquids
US12415165B2 (en) * 2019-10-24 2025-09-16 Fenwal, Inc. Small volume processing systems and methods with capacitive sensing

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199013A (en) * 1977-04-01 1980-04-22 Packard Instrument Company, Inc. Liquid sample aspirating and/or dispensing system
US4326851A (en) * 1980-10-24 1982-04-27 Coulter Electronics, Inc. Level sensor apparatus and method
EP0109198A1 (en) * 1982-11-15 1984-05-23 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Method and apparatus for metering introduction of fluid segments into conduit
US4726237A (en) * 1985-06-19 1988-02-23 Sequoia-Turner Corporation Fluid metering apparatus and method
US4822569A (en) * 1986-06-09 1989-04-18 Fisher Scientific Company Rotary shear valve with cleaning feature and method of using same
US4948565A (en) * 1989-04-25 1990-08-14 Fisher Scientific Company Analytical system
US5094961A (en) * 1990-12-13 1992-03-10 Coulter Corporation Aspiration method for hematology analyzing apparatus
WO1993010432A1 (en) * 1991-11-22 1993-05-27 Coulter Corporation Fluid metering, mixing and transfer valve assembly and analyzing system employing same
US5691486A (en) * 1996-07-30 1997-11-25 Bayer Corporation Apparatus and methods for selecting a variable number of test sample aliquots to mix with respective reagents
US5744099A (en) * 1995-09-15 1998-04-28 Cytek Development Inc. Apparatus for transfer of biological fluids
US5853665A (en) * 1997-09-16 1998-12-29 Coulter International Corp. Apparatus and method for monitoring vent line vacuum

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55136958A (en) * 1979-04-14 1980-10-25 Olympus Optical Co Ltd Automatic analyzer
US4276260A (en) 1980-01-28 1981-06-30 Coulter Electronics, Inc. Fluid transfer mechanism
US4445391A (en) 1981-10-19 1984-05-01 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US4507977A (en) 1981-10-19 1985-04-02 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US4544084A (en) * 1981-12-03 1985-10-01 Cleland Robert K Beverage dispenser
JPS61275661A (ja) * 1985-05-31 1986-12-05 Jeol Ltd 試薬秤量方式
US4702889A (en) 1986-01-16 1987-10-27 Coulter Electronics Inc. Liquid sampling valve
US4752690A (en) 1986-08-11 1988-06-21 Coulter Electronics, Inc. Method and apparatus for detecting incongruities, such as air bubbles, in fluid material
US4896546A (en) 1987-10-26 1990-01-30 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US5255568A (en) 1990-12-13 1993-10-26 Coulter Corporation Liquid sample/reagent metering and delivery method
US5158751A (en) 1990-12-13 1992-10-27 Coulter Corporation Liquid metering and transfer valve assembly
US5525302A (en) * 1991-02-01 1996-06-11 Astle; Thomas W. Method and device for simultaneously transferring plural samples
US5558838A (en) * 1993-09-29 1996-09-24 Becton Dickinson And Company Sample preparation apparatus
JPH07294534A (ja) * 1994-04-28 1995-11-10 New Oji Paper Co Ltd オートサンプラを用いる測定方法
JPH08338849A (ja) * 1995-04-11 1996-12-24 Precision Syst Sci Kk 液体の吸引判別方法およびこの方法により駆動制御される分注装置
US6158269A (en) * 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5843378A (en) * 1995-09-05 1998-12-01 Ljl Biosystems Method of producing a probe for aspirating and dispensing probe having surface sensing capability
TW384398B (en) * 1995-12-19 2000-03-11 Toa Medical Electronics Sample agitating and sucking apparatus
US6083762A (en) * 1996-05-31 2000-07-04 Packard Instruments Company Microvolume liquid handling system

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199013A (en) * 1977-04-01 1980-04-22 Packard Instrument Company, Inc. Liquid sample aspirating and/or dispensing system
US4326851A (en) * 1980-10-24 1982-04-27 Coulter Electronics, Inc. Level sensor apparatus and method
EP0109198A1 (en) * 1982-11-15 1984-05-23 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Method and apparatus for metering introduction of fluid segments into conduit
US4726237A (en) * 1985-06-19 1988-02-23 Sequoia-Turner Corporation Fluid metering apparatus and method
US4822569A (en) * 1986-06-09 1989-04-18 Fisher Scientific Company Rotary shear valve with cleaning feature and method of using same
US4948565A (en) * 1989-04-25 1990-08-14 Fisher Scientific Company Analytical system
US5094961A (en) * 1990-12-13 1992-03-10 Coulter Corporation Aspiration method for hematology analyzing apparatus
WO1993010432A1 (en) * 1991-11-22 1993-05-27 Coulter Corporation Fluid metering, mixing and transfer valve assembly and analyzing system employing same
US5460055A (en) * 1991-11-22 1995-10-24 Coulter Corporation Sampling metering and transfer valve assembly and analyzing system employing same
US5744099A (en) * 1995-09-15 1998-04-28 Cytek Development Inc. Apparatus for transfer of biological fluids
US5691486A (en) * 1996-07-30 1997-11-25 Bayer Corporation Apparatus and methods for selecting a variable number of test sample aliquots to mix with respective reagents
US5853665A (en) * 1997-09-16 1998-12-29 Coulter International Corp. Apparatus and method for monitoring vent line vacuum

Also Published As

Publication number Publication date
DE60043891D1 (de) 2010-04-08
EP1210575A1 (en) 2002-06-05
JP4570120B2 (ja) 2010-10-27
EP1210575B1 (en) 2010-02-24
US6322752B1 (en) 2001-11-27
JP2003508782A (ja) 2003-03-04

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