WO2001013954A1 - Methode de traitement de l'infestation du corps par les insectes - Google Patents
Methode de traitement de l'infestation du corps par les insectes Download PDFInfo
- Publication number
- WO2001013954A1 WO2001013954A1 PCT/US2000/022577 US0022577W WO0113954A1 WO 2001013954 A1 WO2001013954 A1 WO 2001013954A1 US 0022577 W US0022577 W US 0022577W WO 0113954 A1 WO0113954 A1 WO 0113954A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lice
- silicone
- shampoo
- infestation
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Definitions
- This invention relates to the safe and effective treatment of lice, nits (and other infestational insects) by using low surface tension lubricants.
- the invention compromises the direct treatment of body insect infestation with a synthetic lubricant, such as food grade silicon, to effectively kill infesting insects such as lice, and nits, as well as fleas, ticks and other insects.
- a synthetic lubricant such as food grade silicon
- the synthetic lubricant is applied directly to the insects, or is provided as a major (more than 50 volume percent) of a shampoo formulation. If added to a shampoo, the exact effective concentration level above 50% is determined based on both the nature of the synthetic lubricant, and the nature of the shampoo used.
- Silicone was directly applied to the hair of three school children, each of which had been infested with lice and nits. Each of the children applied the silicone directly to his or her hair and left it on for five minutes. After five minutes, the hair was washed first with Prell R shampoo and then with Johnson's Baby Shampoo ® . In all three cases the infestation was successfully ended with one application.
- Silicone was directly applied to the hair of twenty school children, each of which had been infested with lice and nits. Each of the children applied the silicone directly to his or her hair and left it on for ten minutes minutes. After ten minutes, the hair was washed with a shampoo of the parent's choice. In all twenty cases the infestation was successfully ended with one application.
- the preferred embodiment for use as a head lice treatment is to use the Silicone in its pure state, that is Dow Corning 200 fluid, 350 CST.
- the Silicone is water white and has a consistency of light syrup. This form is preferred as it clings easily to the hair.
- the Silicone is applied to the entire head, left on for at least ten minutes, and then washed off with any standard shampoo. Within a short time after application of the shampoo, the area is free of any live lice. Any nits do not mature.
- Other embodiments include the processing of synthetic lubricants into a shampoo that effectively kills ticks, fleas, and other insects.
- concentration of such lubricants, and the amount of time they must remain on the affected area is above 50% by volume and is adjusted depending on the type of insect being treated.
- the ticks took longer to die than the lice did in the prior experiments using pure Silicone treatment.
- ten Amblyomma Americanum ticks were coated with Silicone, and ten were coated with Prell " Shampoo.
- the lubricating properties of the silicone provide a morbidity passageway for interfering with insect respiratory and possibly digestive functions, and accordingly other similar lubricants and Silicone derivatives are effective in such insect control.
- head lice the point of entry where the silicone permeates the head lice is very likely the thoracic spiracle, the honeycomb structure which creates maximum surface area and efficient exchange of air and moisture. The nits are likely affected via the head louse nit operculum which contain doughnut shaped holes. See Meinking, T.L. Current Problems in Dermatology 1 1(3) pp 73-120 May/June 1999. With regard to head lice many natural oils treatments have been attempted but with limited efficacy.
- PIB Polyisobutylene
- Krytox 1514 18 6 1. Ryan, T.W. ; Callahan . T.J.; and Dodge, L.G. in Vegetable Oil Fuels, ASAE Conference , 1982 pg. 72
- the surface tension of polydimethylsiloxane at about 20.9 dynes/cm is about 50% lower than the surface tension of most natural oils and is believed to account for its greater ability to penetrate and induce morbidity in insects.
- Krytox® 1514 a fluorinated oil PerFluoroPolyEther (PFPE), with a surface tension of 18, we found that it was also effective in killing lice but slightly less effective than Dow Corning 200 fluid, 350 CST .
- PFPE fluorinated oil PerFluoroPolyEther
- Viscosity or kinematic viscosity is measured in stokes, and is defined to be the dynamic viscosity divided by the density of the liquid; this gives a quantity which depends only on the type of the liquid, independent of its concentration or density.
- Krytoxl 514 has a viscosity of 142 centistokes (cst). while Dow Corning 200 fluid, 350 CST has a viscosity of 350 cst. The viscosity adds to the effectiveness by creating better adhesion of the lubricant to the insects.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catching Or Destruction (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001518089A JP2003507436A (ja) | 1999-08-19 | 2000-08-17 | 身体への虫寄生の治療法 |
NZ517149A NZ517149A (en) | 1999-08-19 | 2000-08-17 | Method of treating body insect infestation using a low surface tension lubricant |
CA2382177A CA2382177C (fr) | 1999-08-19 | 2000-08-17 | Methode de traitement de l'infestation du corps par les insectes |
US09/937,627 US6683065B1 (en) | 1999-08-19 | 2000-08-17 | Method of treating body insect infestation |
AU67813/00A AU780713B2 (en) | 1999-08-19 | 2000-08-17 | Method of treating body insect infestation |
IL14813800A IL148138A0 (en) | 1999-08-19 | 2000-08-17 | Method of treating body insect infestation |
EP00955645A EP1207908A4 (fr) | 1999-08-19 | 2000-08-17 | Methode de traitement de l'infestation du corps par les insectes |
MXPA02001759A MXPA02001759A (es) | 1999-08-19 | 2000-08-17 | Metodo para tratar la infestcion corporal de insectos. |
BR0013437-6A BR0013437A (pt) | 1999-08-19 | 2000-08-17 | Método para tratamento de infestação do corpo por insetos |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14947199P | 1999-08-19 | 1999-08-19 | |
US60/149,471 | 1999-08-19 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/937,627 A-371-Of-International US6683065B1 (en) | 1999-08-19 | 2000-08-17 | Method of treating body insect infestation |
US10/232,472 Continuation US20030013683A1 (en) | 1999-08-19 | 2002-08-30 | Method of treating body insect infestation |
US10/889,717 Continuation US20040242541A1 (en) | 1999-08-19 | 2004-07-12 | Method of treating body insect infestation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001013954A1 true WO2001013954A1 (fr) | 2001-03-01 |
Family
ID=22530431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/022577 WO2001013954A1 (fr) | 1999-08-19 | 2000-08-17 | Methode de traitement de l'infestation du corps par les insectes |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1207908A4 (fr) |
JP (1) | JP2003507436A (fr) |
AU (1) | AU780713B2 (fr) |
BR (1) | BR0013437A (fr) |
CA (1) | CA2382177C (fr) |
IL (1) | IL148138A0 (fr) |
MX (1) | MXPA02001759A (fr) |
NZ (1) | NZ517149A (fr) |
WO (1) | WO2001013954A1 (fr) |
ZA (1) | ZA200201195B (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350734B1 (en) | 1999-01-26 | 2002-02-26 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6663876B2 (en) | 2002-04-29 | 2003-12-16 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US7829551B2 (en) | 1999-09-16 | 2010-11-09 | Durminster Limited | Method and composition for the control of arthropods |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2470208B (en) * | 2009-05-14 | 2014-01-29 | Thornton & Ross Ltd | A method and composition for the control of ectoparasites |
JP2019081752A (ja) * | 2017-10-30 | 2019-05-30 | アース製薬株式会社 | 吸血性害虫の定着阻害方法及び吸血性害虫の定着阻害剤 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5876705A (en) * | 1995-10-16 | 1999-03-02 | The Procter & Gamble Co. | Conditioning shampoo compositions |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4155995A (en) * | 1973-03-23 | 1979-05-22 | Witco Chemical Corporation | Petroleum based mosquito larvicide |
US4146619A (en) * | 1977-05-31 | 1979-03-27 | Block Drug Company Inc. | Siloxane toxicants |
JPS5939809A (ja) * | 1982-08-31 | 1984-03-05 | Shin Etsu Chem Co Ltd | 衛生・農業害虫駆除剤 |
EP0191543A1 (fr) * | 1985-01-15 | 1986-08-20 | Ventec Laboratories, Inc. | Toxiques de silicone contre les insectes |
GB8613914D0 (en) * | 1986-06-07 | 1986-07-09 | Coopers Animal Health | Liquid formulations |
DK0525078T3 (da) * | 1990-04-18 | 1997-08-25 | Procter & Gamble | Præparater til behandling af lus |
JPH04334305A (ja) * | 1991-05-09 | 1992-11-20 | Mitsubishi Kasei Corp | 殺虫・殺ダニ剤組成物 |
JPH07206615A (ja) * | 1993-11-25 | 1995-08-08 | Dainippon Jochugiku Co Ltd | 防虫剤組成物 |
DE19544669A1 (de) * | 1995-11-30 | 1997-06-05 | Bayer Ag | Schädlingsbekämpfungsmittel auf Basis cyclischer Polysiloxane |
DK1215965T3 (da) * | 1999-09-16 | 2004-02-16 | Durminster Ltd | Fremgangsmåde og præparat til bekæmpelse af arthropoder |
-
2000
- 2000-08-17 WO PCT/US2000/022577 patent/WO2001013954A1/fr active IP Right Grant
- 2000-08-17 MX MXPA02001759A patent/MXPA02001759A/es active IP Right Grant
- 2000-08-17 JP JP2001518089A patent/JP2003507436A/ja active Pending
- 2000-08-17 IL IL14813800A patent/IL148138A0/xx active IP Right Review Request
- 2000-08-17 CA CA2382177A patent/CA2382177C/fr not_active Expired - Lifetime
- 2000-08-17 EP EP00955645A patent/EP1207908A4/fr not_active Withdrawn
- 2000-08-17 BR BR0013437-6A patent/BR0013437A/pt not_active Application Discontinuation
- 2000-08-17 AU AU67813/00A patent/AU780713B2/en not_active Expired
- 2000-08-17 NZ NZ517149A patent/NZ517149A/en not_active IP Right Cessation
-
2002
- 2002-02-12 ZA ZA200201195A patent/ZA200201195B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5876705A (en) * | 1995-10-16 | 1999-03-02 | The Procter & Gamble Co. | Conditioning shampoo compositions |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6350734B1 (en) | 1999-01-26 | 2002-02-26 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6541455B2 (en) | 1999-01-26 | 2003-04-01 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US7829551B2 (en) | 1999-09-16 | 2010-11-09 | Durminster Limited | Method and composition for the control of arthropods |
US6663876B2 (en) | 2002-04-29 | 2003-12-16 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US8178116B2 (en) | 2002-04-29 | 2012-05-15 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US8815270B2 (en) | 2002-04-29 | 2014-08-26 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
Also Published As
Publication number | Publication date |
---|---|
AU780713B2 (en) | 2005-04-14 |
IL148138A0 (en) | 2002-09-12 |
EP1207908A1 (fr) | 2002-05-29 |
CA2382177A1 (fr) | 2001-03-01 |
JP2003507436A (ja) | 2003-02-25 |
EP1207908A4 (fr) | 2002-09-11 |
CA2382177C (fr) | 2011-10-11 |
ZA200201195B (en) | 2003-04-30 |
BR0013437A (pt) | 2002-04-30 |
MXPA02001759A (es) | 2003-07-14 |
NZ517149A (en) | 2004-01-30 |
AU6781300A (en) | 2001-03-19 |
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