WO2000072776A1 - Couche appliquee sur un implant destine a une structure osseuse ou tissulaire, un tel implant et procede d'application de cette couche - Google Patents

Couche appliquee sur un implant destine a une structure osseuse ou tissulaire, un tel implant et procede d'application de cette couche Download PDF

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Publication number
WO2000072776A1
WO2000072776A1 PCT/SE2000/001026 SE0001026W WO0072776A1 WO 2000072776 A1 WO2000072776 A1 WO 2000072776A1 SE 0001026 W SE0001026 W SE 0001026W WO 0072776 A1 WO0072776 A1 WO 0072776A1
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WO
WIPO (PCT)
Prior art keywords
implant
layer
bone
channel
layer according
Prior art date
Application number
PCT/SE2000/001026
Other languages
English (en)
Inventor
Jan Hall
Jukka Lausmaa
Original Assignee
Nobel Biocare Ab (Publ)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Biocare Ab (Publ) filed Critical Nobel Biocare Ab (Publ)
Priority to EP00937435A priority Critical patent/EP1191901B1/fr
Priority to JP2000620890A priority patent/JP4695265B2/ja
Priority to DE60019752T priority patent/DE60019752T2/de
Priority to AU52608/00A priority patent/AU779517B2/en
Priority to US09/980,006 priority patent/US7713307B1/en
Priority to CA2373701A priority patent/CA2373701C/fr
Priority to AT00937435T priority patent/ATE293932T1/de
Priority to DK00937435T priority patent/DK1191901T3/da
Publication of WO2000072776A1 publication Critical patent/WO2000072776A1/fr
Priority to US12/748,867 priority patent/US8152856B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A61C8/0015—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating being a conversion layer, e.g. oxide layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Definitions

  • Layer arranged on implant for bone or tissue structure, such an implant, and a method for application of the layer.
  • the present invention relates to a layer which can be arranged on an implant for bone or tissue structure and which is intended to constitute a boundary or barrier between the body of the implant and the structure for the purpose of increasing retention and which has, in this context, a substantial thickness.
  • the invention also relates to an implant with such a layer, and to a method for producing the said layer on the implant.
  • the present invention is based on the recognition that the oxide layer structure used in this context can have a decisive influence for improving implantation and incorporation processes.
  • the aim of the invention is primarily to solve this problem.
  • it is important to establish good corrosion resistance and, for example in connection with the use of hydrogen fluoride (HF) , to avoid the occurrence of brittleness.
  • HF hydrogen fluoride
  • the oxide layer is also important to be able to have a structure which eliminates or to a large extent counteracts mechanical stress concentrations in implants inserted in the bone or equivalent, cf . the built-in stresses which can occur in connection with etched surfaces. Further demands and requirements are that the process of incorporation of the implant in the bone or tissue can be improved. The invention solves this problem too.
  • the implant it is possible in some cases (i.e. in one embodiment) to use bone- growth-initiating and bone-growth-stimulating agents and substances, for example those belonging to the superfamily TGF- ⁇ . It is important to be able to apply the agent or the substance to or on the implant in a technically simple and economically advantageous manner.
  • the invention also solves this problem and proposes, through the novel oxide layer structure, a suitable depot function which can be used in long-term and optimal bone growth situations and incorporation functions for the implant in the bone or equivalent.
  • the present invention also proposes methods satisfying the conditions for production of oxide layers of the type in question.
  • the method is based on the recognition that the electrolyte composition and/or the electrical voltages used can be of decisive importance.
  • the feature which can principally be regarded as characterizing a layer according to the invention is that it is designed with a channel network which gives the layer a substantial porosity, and that the channel network is designed with mouths which face towards the structure and whose respective cross-sectional areas, at the surface of the layer facing towards the structure, are substantially less than the respective extents of the channels in and down into the layer as seen from the said surface.
  • the channel network comprises contiguous channel branches which extend through at least the greater part of the layer as seen from the said surface and in to the transition to the body of the implant.
  • the layer can be established on an undulating or uneven surface present on the implant from the start and having a high roughness value (for example 0.4 - 5 ⁇ m) for the purpose of increasing the layer volume.
  • the channel network can also have channel branches which extend in directions which are different from the depth direction of the layer (or the radial direction of the implant) .
  • the layer has a thickness which gives substantial corrosion resistance in relation to the previously proposed oxide layer arrangements.
  • the channel network can also be arranged with a mouth arrangement towards the bone or tissue structure, permitting increased release of bone growth substance from the channel network via the said mouths .
  • the layer can be given an average thickness in accordance with the attached patent claims. Preferred values in respect of the surface area sizes of the mouths of the channel network, the total channel or pore volume in the layer, the surface roughness and the porosity are likewise indicated in the attached patent claims.
  • an implant according to the invention can principally be regarded as being characterized by the fact that each layer present on the implant is designed with a channel network which gives the layer a substantial porosity, and by the fact that the channel network is designed with mouths which face towards the structure and whose respective cross-sectional areas, at the surface of the layer facing towards the structure, are substantially less than the respective extents of the channels in and down into the layer as seen from the said surface.
  • the implant can consist of a screw implant for application in bone, for example dentine.
  • the oxide layer can form a depot for applied bone-growth-initiating or bone-growth-stimulating agent or substance. The agent or the substance can migrate from the depot to the bone or tissue structure by means of concentration diffusion, which can be optimized by means of the channel network's mouth arrangement facing towards the bone or tissue structure.
  • the layer consists of or comprises a titanium oxide layer.
  • a method according to the invention starts out from anodic oxidation of the implant material in question.
  • the method can principally be characterized by the fact that diluted inorganic acids, diluted organic acids and/or small quantities of hydrofluoric acid or hydrogen peroxide are added to the electrolytic composition which is used in the method, and by the fact that the energy source is chosen to operate with a voltage value of at least 150 volts.
  • voltage values in the range of 200 - 400 volts can be used.
  • the voltage varies at times for the same implant in order to create different channel or pore sizes within the same surface area or surface areas of the implant.
  • different porosities or pore or channel characteristics can be obtained by means of the position of the implant in the electrolyte being changed, together with the choice of the electrolyte composition and/or the voltage used.
  • the oxide thickness can also be varied by means of the said parameters .
  • Figure 1 shows, in longitudinal section, an illustrative embodiment of a titanium oxide layer produced on an implant body, the oxide layer starting from a relatively plane surface on the implant body,
  • Figure 2 shows, in longitudinal section, an example of the position of the oxide layer on an undulating surface or on a surface with a high degree of surface roughness
  • Figure 3 shows a plan view, from outside, of an example of a mouth arrangement for a channel network arranged in the oxide layer
  • Figure 4 shows, in vertical section and in diagrammatic form, a channel network for an oxide layer produced on an implant body, where the implant with associated oxide layer is applied in a partially shown bone and/or tissue structure in the human body, and in the oxide layer there is a channel network with a mouth arrangement facing towards the structure,
  • Figure 5 shows a side view of equipment for anodic oxidation of an implant
  • Figure 6 shows, in diagram form, the voltage and current functions used in association with the oxidation process
  • Figure 7 shows, in table form, parameters for building up different titanium oxide layers.
  • reference number 1 indicates parts of an implant body.
  • the implant body has been treated in an oxidation function, resulting in an oxidation layer 2 having been formed on its outer surface.
  • the oxidation layer can be built up on a surface structure which is relatively smooth from the outset, as has been indicated by 3 in Figure 1.
  • the oxide layer 2 has a considerable thickness T.
  • the layer can assume values of between 0.5 and 10 ⁇ m, with the values preferably being towards the upper limit of the range. According to the invention, the invention will function primarily in the range of 2 - 10 ⁇ m, although values as low as 0.5 ⁇ m may be used in certain exceptional cases.
  • the outer surface 2a of the oxide layer must have a surface roughness within the range of
  • the oxide layer 2 has a high degree of porosity and encloses a channel network of specific type.
  • Figure 2 shows an example which differs from that in Figure 1 and where the oxide layer 2' has been built up on a surface structure 3 ' located on the implant 1' and having a relatively high degree of surface roughness, which has been obtained in a manner known per se upon production of the implant (e.g. by etching) .
  • the embodiment according to Figure 2 satisfies conditions for a relatively greater oxide layer volume than in the case according to Figure 1.
  • Figure 3 shows, from the outside of the oxide layer 2 ' ' , mouths 3, 4 leading from the channel network mentioned above.
  • the scale is shown at the bottom right-hand corner, i.e. the size 10 ⁇ m length in each figure.
  • the implant is indicated by 1 ' ' and the oxide layer produced on the implant is indicated by 2' ' ' .
  • a bone or tissue structure is indicated symbolically by 5.
  • the structure can consist, for example, of a jaw bone in which the implant can be screwed down into the bone or equivalent.
  • the implant can thus consist of or comprise titanium material, which means that the layer 2' ' ' consists of a titanium oxide layer.
  • the screw or the thread of the implant is not indicated in Figure 4, but reference may be made to the already disclosed prior art and to known implants.
  • the corresponding thread in the jaw bone 5 is not shown either, but here again reference may be made to the prior art.
  • the oxide layer 2 ' ' ' which is designed with the considerable thickness T' , e.g. a thickness in the range of 5 - 25 ⁇ m, is provided with a channel network which is indicated symbolically by the arrow 6.
  • the channel network has mouths or openings 3', 4 ' .
  • the channel network branches down and/or in to the oxide layer, as seen from the outside 7 of the oxide layer.
  • the channel network comprises different channel parts, for example 8, 9, 10.
  • Channel routes can be established through the channel network which are made up of different channel parts and run from the outside 2a' of the layer 2''' and down or in towards a transition 11 between the implant and the oxide layer.
  • Such a continuous channel formation is established with the channel parts or channel branches 12, 13, 14, 15 in the figure.
  • a characteristic of the channel or pore formation according to the invention is that the surface area or the diameter D of each mouth is substantially less than the respective channel boundary or pore depth, for example a pore depth H.
  • the pore depth or channel depth can be significant and correspond, for example, to the said thickness T' .
  • the channels can extend in the direction of depth of the oxide layer 2' ' ' and/or in directions which are different than this direction, or in the radial direction R of the implant.
  • the channel branches or the channel parts can be straight and/or curved, a curved channel branch having been indicated by 16 in Figure 4.
  • such a channel system can constitute a depot for substance which stimulates and/or initiates bone growth, and this has been symbolized by 17 in Figure 4.
  • a substance thus introduced into the channel network can, by means of concentration diffusion, migrate out into the bone or tissue structure, as has been symbolized by the arrow 18 in Figure 4.
  • bone or tissue organisms can pass into the system in conjunction with the said diffusion.
  • the mouths can be given different sizes and can create conditions for bone growth with a specific penetration function in the mouth arrangement, contributing to the degree of incorporation of the implant in the structure.
  • the oxide layer of high porosity can be formed with 1 x 10 7 - 1 x 10 10 pores (channel mouths) /cm 2 .
  • the diameter sizes can be chosen in the range of 0.1 - 10 ⁇ m, and one and the same surface area of the oxide layer can have pores or channel mouths of different diameters or surface areas.
  • a total volume for the channel network according to Figure 4 can be chosen in a range of 5 x 10 "2 and 10 "5 cm 3 .
  • the titanium oxide layers according to the above are preferably produced by so-called anodic oxidation, which is an electrochemical process.
  • anodic oxidation which is an electrochemical process.
  • the principle and the procedure for producing the layers in question are described with reference to Figures 5 and 6.
  • a container is indicated by 20.
  • a titanium anode is indicated by 21, and a porous meshed cathode is indicated by 22.
  • a Teflon insulation of the titanium anode is indicated by 23, and the anodes extend through a Teflon cover 24.
  • a magnetic agitator 25 is also included.
  • the attachments for anode and cathode are indicated by 21' and 22', respectively.
  • the implant or the parts of the implant which are to be prepared are preferably mechanically worked by turning, milling, polishing, etc.
  • the implant or parts in question comprise titanium surfaces which are to be treated in the electrochemical process.
  • the implant or parts in question are mounted on a holder which is immersed in a bath in the container consisting of an electrolyte 26. Those parts of the implant which are not to be treated are masked by a liquid-tight protective sleeve or alternatively with a suitable lacquer which is arranged on the parts which are not to be treated.
  • the implant or its said parts are in electrical contact, via the holder, with the attachment 21' above the surface of the electrolyte.
  • the said cathode 22 functions as a counter-electrode.
  • This counter-electrode is made of suitable material, for example Pt , gold or graphite.
  • the counter-electrode is preferably mounted on the holder in such a way that the whole arrangement is jointly fixed in the electrolyte bath 26.
  • the anodic oxidation is obtained by applying an electrical voltage between implant/implant part/implant parts and counter- electrode, whereupon the implant or its part or parts in question are given positive potential.
  • the implant, implant part/implant parts, the counter electrode and the electrolyte constitute an electrochemical cell in which the implant or its respective part forms an anode.
  • the difference in electrical potential between implant/implant part and counter-electrode gives rise to a stream of negatively (positive) charged electrolyte ions to the implant or implant part (counter-electrode) .
  • the electrolyte reactions in the cell result in formation of an oxide layer on the implant or surface of the implant part . Since the electrode reactions also result in gas formation, the electrolyte should be stirred in a suitable manner, which is done with magnetic agitator 25, preventing gas bubbles from remaining on the electrode surfaces.
  • the formation of the titanium oxide layer and its final properties are affected by a number of parameters in the process, e.g. the electrolyte's composition and temperature, the voltage and current applied, the electrode geometry and the treatment time.
  • the electrolyte's composition and temperature e.g. the electrolyte's composition and temperature, the voltage and current applied, the electrode geometry and the treatment time.
  • the way in which the desired layers are produced is described in more detail below. Examples are also given of how the process parameters affect various properties of the oxide layers and how the oxide thickness and porosity can be varied.
  • a mechanically worked surface which can be turned or polished.
  • Cast and pressed implants or implant parts can also be used.
  • the surface is cleaned in a suitable manner, for example by ultrasound cleaning in organic solvents in order to remove impurities from previous production stages.
  • the cleaned implant or the cleaned implant part is secured in the said container, which is secured together with the counter-electrode on the holder.
  • the arrangement can then be immersed in the electrolyte.
  • the two electrodes are thereafter coupled to a voltage source
  • the electrical voltage can be applied in different ways, cf. also Figure 6.
  • a galvanostatic process the current is kept constant, the voltage being allowed to vary according to the resistance in the cell, whereas, in a potentiostatic process, the voltage instead is kept constant and the current is allowed to vary.
  • the desired layers are formed preferably by using a combination of galvanostatic and potentiostatic control. Galvanostatic control is used in a first stage, the voltage being allowed to increase to a preset value. When this voltage value has been reached, the process changes over to potentiostatic control . On account of the resistance of the oxide layer which has been formed, the current drops in this state.
  • Figure 6 shows the development of the current 27 and voltage 28 over time. The exact appearance of the curves depends on various process parameters and also reflects the formation of the oxide layer and its properties.
  • oxide layers Up to a certain voltage, which is dependent on electrolyte, relatively thin oxide layers ( ⁇ 0.2 ⁇ m) are obtained, where the oxide layer thickness is approximately linearly dependent on the applied voltage, and independent of treatment time after the maximum voltage has been reached. These layers are essentially closed, and only in exceptional circumstances do they have a partially open porosity. For most electrolytes, the critical voltage is about 100 volts.
  • Suitable electrolytes for achieving porous layers using this method are diluted inorganic acids (e.g. sulphuric acid, phosphoric acid, chromic acid) and/or diluted organic acids (e.g. acetic acid, citric acid), or mixtures of these.
  • the implant which is treated in sulphuric acid has a surface with high density and open pores . Some 20% of the surface consists of pores or channels/ channel branches, with sizes (diameters) preferably in the range of 0.1 - 0.5 ⁇ m.
  • the thickness of the layer can be 2 ⁇ m.
  • the implant which is treated in phosphoric acid has a similar density of pores. The pore size distribution can differ considerably. In the case shown, pore sizes can be chosen preferably in the range of 0.3 - 0.5 ⁇ m, but a good number of larger pores (up to 1.5 ⁇ m) can also be present on the surface.
  • the oxide thickness in this embodiment is 5 ⁇ m.
  • the table according to Figure 7 shows the structure of the oxide layer made with different process parameters in this method.
  • the parameters shown are the electrolyte composition, voltage (volts) , current (mA) , time, pore diameter, pore density, porosity and oxide thickness.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ceramic Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une couche (2''') appliquée sur un implant (1'') destiné à une structure osseuse ou tissulaire (5). Cette couche forme une limite ou une barrière entre le corps actuel ou non oxydé (1'') de l'implant et la structure en vue d'augmenter la rétention d'eau et a, en l'occurrence, une importante épaisseur (T'). Cette couche est pourvue d'un réseau de canaux (6) qui lui confère une grande porosité. Le réseau de canaux est conçu avec des bouches (3', 4') qui font face à la structure et dont les diamètres transversaux respectifs (D), à la surface (2a') de la couche faisant face à la structure (5), sont nettement inférieurs à la longueur respective (par ex. H) des canaux pénétrant dans la couche vu de ladite surface (2a').
PCT/SE2000/001026 1999-05-31 2000-05-23 Couche appliquee sur un implant destine a une structure osseuse ou tissulaire, un tel implant et procede d'application de cette couche WO2000072776A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP00937435A EP1191901B1 (fr) 1999-05-31 2000-05-23 Couche appliquée sur un implant pour une structure osseuse ou tissulaire et procédé d'application de cette couche.
JP2000620890A JP4695265B2 (ja) 1999-05-31 2000-05-23 骨または組織構造用のインプラント上に配置される層、およびかかるインプラント
DE60019752T DE60019752T2 (de) 1999-05-31 2000-05-23 Beschichtung eines Implantates für Knochen oder Gewebe und Verfahren zum Aufbringen dieser Beschichtung.
AU52608/00A AU779517B2 (en) 1999-05-31 2000-05-23 Layer arranged on implant for bone or tissue structure, such an implant, and a method for application of the layer
US09/980,006 US7713307B1 (en) 1999-05-31 2000-05-23 Layer arranged on implant for bone or tissue structure
CA2373701A CA2373701C (fr) 1999-05-31 2000-05-23 Couche appliquee sur un implant destine a une structure osseuse ou tissulaire, un tel implant et procede d'application de cette couche
AT00937435T ATE293932T1 (de) 1999-05-31 2000-05-23 Beschichtung eines implantates für knochen oder gewebe und verfahren zum aufbringen dieser beschichtung.
DK00937435T DK1191901T3 (da) 1999-05-31 2000-05-23 Lag anbragt på et implantat til knogle- eller vævsstruktur og fremgangsmåde til påföring af dette lag
US12/748,867 US8152856B2 (en) 1999-05-31 2010-03-29 Layer arranged on implant for bone or tissue structure, such an implant, and a method for application of the layer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901974-7 1999-05-31
SE9901974A SE514202C2 (sv) 1999-05-31 1999-05-31 På implantat till ben- eller vävnadsstruktur anordnat skikt samt sådant implantat och förfarande för applicering av skiktet

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/980,006 A-371-Of-International US7713307B1 (en) 1999-05-31 2000-05-23 Layer arranged on implant for bone or tissue structure
US12/748,867 Continuation US8152856B2 (en) 1999-05-31 2010-03-29 Layer arranged on implant for bone or tissue structure, such an implant, and a method for application of the layer

Publications (1)

Publication Number Publication Date
WO2000072776A1 true WO2000072776A1 (fr) 2000-12-07

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PCT/SE2000/001026 WO2000072776A1 (fr) 1999-05-31 2000-05-23 Couche appliquee sur un implant destine a une structure osseuse ou tissulaire, un tel implant et procede d'application de cette couche

Country Status (11)

Country Link
US (2) US7713307B1 (fr)
EP (1) EP1191901B1 (fr)
JP (2) JP4695265B2 (fr)
AT (1) ATE293932T1 (fr)
AU (1) AU779517B2 (fr)
CA (1) CA2373701C (fr)
DE (1) DE60019752T2 (fr)
DK (1) DK1191901T3 (fr)
ES (1) ES2239009T3 (fr)
SE (1) SE514202C2 (fr)
WO (1) WO2000072776A1 (fr)

Cited By (25)

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WO2003003939A1 (fr) * 2001-07-04 2003-01-16 Nobel Biocare Ab (Publ) Implant, par exemple implant dentaire
WO2003003938A1 (fr) * 2001-07-04 2003-01-16 Nobel Biocare Ab (Publ) Arrangement et procede de fourniture d'accessoires de prothese essentiellement faits en titane
WO2003003937A1 (fr) * 2001-07-04 2003-01-16 Nobel Biocare Ab (Publ) Procede de traitement d'implant et implant traite selon ce procede
WO2003003936A1 (fr) * 2001-07-04 2003-01-16 Nobel Biocare Ab (Publ) Implant
JP2003190272A (ja) * 2001-10-17 2003-07-08 Tadashi Kokubo 生体親和性に優れた骨代替材料およびその製造方法
WO2004010891A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Dispositif permettant d'augmenter la resistance a la contrainte d'implants et lesdits implants
WO2004010887A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Moyen d'utilisation d'une matiere osteoinductive ou bioactive pour induire la croissance osseuse et/ou pour ameliorer la stabilite des implants dans l'os de la machoire, implant utilise a cet effet
WO2004010888A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Agencement d'utilisation d'un materiau bioactif ou osteoinducteur pour former un support lateral a base d'os pour implants dans l'os de la machoire
WO2004010890A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Agencement de deux implants ou plus dotes de substances stimulant la croissance
WO2004010889A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Dispositif pour implants comportant une ou des matiere(s) stimulant la croissance, et implant correspondant
WO2005089829A2 (fr) 2004-03-10 2005-09-29 Scil Technology Gmbh Implants revetus, fabrication et utilisation de ceux-ci
WO2007090433A2 (fr) * 2006-02-09 2007-08-16 Plus Orthopedics Ag Oxydes purifies avec de nouvelles morphologies formees a partir d'alliages de ti
DE102008026557A1 (de) 2008-06-03 2009-12-17 Königsee Implantate und Instrumente zur Osteosynthese GmbH Elektrochemisch hergestellte, biologisch degradationsstabile, duktile und haftfeste Titanoxid-Oberflächenschicht auf Titan oder Titanbasislegierungen
DE102008026558A1 (de) 2008-06-03 2010-01-14 Königsee Implantate und Instrumente zur Osteosynthese GmbH Elektrochemisches Tauchverfahren in einem wässrigen Elektrolyt zur Erzeugung einer biologisch degradationsstabilen Oberflächenschicht auf Grundkörpern aus Titan oder Titanbasislegierungen
US7763270B2 (en) 2002-09-10 2010-07-27 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
WO2010097214A1 (fr) 2009-02-26 2010-09-02 Nobel Biocare Services Ag Dispositif pour indiquer la position et l'orientation d'un implant dentaire
AU2004296171B2 (en) * 2003-12-11 2010-09-09 Nobel Biocare Services Ag Arrangement with an implant and/or a unit belonging to said implant, and method for production of the implant and/or unit
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US8771361B2 (en) 2002-07-25 2014-07-08 Nobel Biocare Services Ag Arrangement for increasing the stress resistance of implants and one such implant
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US8257728B2 (en) 2002-09-10 2012-09-04 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
AU2004296171B2 (en) * 2003-12-11 2010-09-09 Nobel Biocare Services Ag Arrangement with an implant and/or a unit belonging to said implant, and method for production of the implant and/or unit
US9931184B2 (en) 2003-12-11 2018-04-03 Nobel Biocare Services Ag Arrangement with an implant and/or a unit belonging to said implant, and method for production of the implant and/or unit
EP2361588A3 (fr) * 2003-12-11 2011-12-14 Nobel Biocare Services AG Agencement avec implant et/ou unité appartenant à cet implant et procédé de production de l'implant et/ou de l'unité
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US8372419B2 (en) 2004-03-10 2013-02-12 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
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EP2712573A2 (fr) 2009-02-26 2014-04-02 Nobel Biocare Services AG Dispositif pour indiquer la position et l'orientation d'un implant dentaire
WO2010097214A1 (fr) 2009-02-26 2010-09-02 Nobel Biocare Services Ag Dispositif pour indiquer la position et l'orientation d'un implant dentaire
EP2264425A1 (fr) 2009-06-18 2010-12-22 Nobel Biocare Services AG Procédé et agencement de polissage d'un échantillon d'implant
CN103732802A (zh) * 2010-06-11 2014-04-16 阿山特斯医疗有限公司 金属处理
US8888983B2 (en) 2010-06-11 2014-11-18 Accentus Medical Limited Treating a metal implant with a rough surface portion so as to incorporate biocidal material
WO2011154715A3 (fr) * 2010-06-11 2014-01-09 Accentus Medical Limited Traitement du métal
CN103732802B (zh) * 2010-06-11 2017-05-03 阿山特斯医疗有限公司 金属处理
FR2971142A1 (fr) * 2011-02-09 2012-08-10 Eric Blois Procede de fabrication d'un tenon dentaire et tenon dentaire obtenu selon ledit procede
EP2517737A2 (fr) 2011-04-21 2012-10-31 ZL Microdent-Attachment GmbH & Co. KG Implant et procédé de fabrication d'une surface d'implant
DE102011018677A1 (de) 2011-04-21 2012-10-25 Zl Microdent-Attachment Gmbh & Co. Kg Implantat und Verfahren zur Herstellung einer Implantatoberfläche
US9938631B2 (en) 2011-06-09 2018-04-10 DePuy Synthes Products, Inc. Anodizing container
EP3034033A1 (fr) 2014-12-16 2016-06-22 Nobel Biocare Services AG Implant dentaire
EP3590463A1 (fr) 2014-12-16 2020-01-08 Nobel Biocare Services AG Implant dentaire
US11357600B2 (en) 2014-12-16 2022-06-14 Nobel Biocare Services Ag Dental implant
US11918434B2 (en) 2014-12-16 2024-03-05 Nobel Biocare Services Ag Dental implant

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CA2373701C (fr) 2010-06-22
SE9901974L (sv) 2000-12-01
CA2373701A1 (fr) 2000-12-07
DE60019752D1 (de) 2005-06-02
EP1191901B1 (fr) 2005-04-27
DE60019752T2 (de) 2006-01-19
US20100185293A1 (en) 2010-07-22
SE514202C2 (sv) 2001-01-22
DK1191901T3 (da) 2005-08-15
US8152856B2 (en) 2012-04-10
ATE293932T1 (de) 2005-05-15
EP1191901A1 (fr) 2002-04-03
AU779517B2 (en) 2005-01-27
JP2009000546A (ja) 2009-01-08
ES2239009T3 (es) 2005-09-16
SE9901974D0 (sv) 1999-05-31
AU5260800A (en) 2000-12-18
US7713307B1 (en) 2010-05-11
JP2003500159A (ja) 2003-01-07
JP4695265B2 (ja) 2011-06-08

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