WO2000047242A1 - Materiau de suture de plaies a base de methylidene malonate - Google Patents
Materiau de suture de plaies a base de methylidene malonate Download PDFInfo
- Publication number
- WO2000047242A1 WO2000047242A1 PCT/FR2000/000305 FR0000305W WO0047242A1 WO 2000047242 A1 WO2000047242 A1 WO 2000047242A1 FR 0000305 W FR0000305 W FR 0000305W WO 0047242 A1 WO0047242 A1 WO 0047242A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- weight
- methylidene malonate
- molecular weight
- formula
- equal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
- C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
Definitions
- the present invention relates to a new wound suture material based on methylidene malonate.
- suture material is intended to denote a biocompatible material which makes it possible, by adhesion, to join the lips of wounds, to stop bleeding (hemostasis) and to promote the scarring of injured tissue.
- the invention essentially finds application in the field of treatment of epidermal, dermo-epidermal or hypo-dermo-epidermal wounds, in particular frank dermo-epidermal wounds.
- Wire suturing is generally used to bring together the superficial dermal and epidermal planes, in the case of non-absorbable threads, or to bring together the deep muscular and hypodermic planes in the case of absorbable threads. This treatment method is currently the most commonly used.
- this mode of treatment is more or less traumatic psychologically for the patient, especially when it comes to children, for whom a quick and painless gesture is necessary.
- the stapling poses, in practice, substantially the same problems as thread suturing.
- the application of adhesive strips such as for example the product known under the trade name Stéri-Strip ® , makes it possible to treat minor wounds in a practically painless manner.
- glues These adhesive materials generally designated by the term “glues” can be divided into two categories:
- - synthetic glues mainly based on cyanoacrylate, and in particular, 2-octylcyanoacrylate, 2-ethylcyanoacrylate, 2-butylcyanoacrylate and 2-isobutylcyanoacrylate.
- Biological glues are products chosen to reproduce the last phase of coagulation and to anchor the clot to the tissue via the supply of fibronectin ("junction protein") to the healing sites.
- these adhesives are generally potentially allergenic and are very difficult to degrade in the body, generally forming products considered to be toxic for the latter, which considerably limits their interest.
- the present invention aims to solve the technical problem consisting in the supply of a new wound suture material, of essentially synthetic nature, which has the same advantages as the abovementioned synthetic glues, which is of a easy implementation, which can be degraded relatively easily in the body without generating toxic products and which can be applied inside the wound in all the damaged skin layers.
- the present invention also aims to solve the aforementioned technical problem in a manner applicable on an industrial scale.
- compositions based on monomers and / or oligomers and / or polymers based on methylidene malonate have all the required properties, in particular in terms of bio-adhesion and viscosity before and / or after application, to make new wound suturing materials that meet this objective.
- the subject of the present invention is a wound suturing material consisting of a biocompatible, bio-adhesive mixture comprising at least 50% by weight, and preferably at least 80% by weight, of a composition based on methylidene malonate containing:
- Ri and R 2 independently represent a linear or branched alkyl group having from 1 to 6 carbon atoms, and n is an integer included between 1 and 5; and / or one or more methylidene malonate oligomer (s) having a molecular weight less than or equal to 6,000 and consisting of recurring units of formula (II):
- A represents a group (a) in which R 1 represents an alkyl group having from 1 to 6 carbon atoms, preferably an ethyl group,
- R represents an alkyl group having from 1 to 6 carbon atoms, preferably an ethyl group, and n is a number equal to 1.
- the above-mentioned methylidene malonate composition contains:
- methylidene malonate oligomer (s) having a molecular weight less than or equal to 6,000 preferably less than or equal to 3,000 and consisting of recurring units of formula (II) ,
- the above-mentioned methylidene malonate composition contains: - from 55 to 65% by weight of one or more methylidene malonate oligomer (s) having a molecular weight less than or equal to 3,000, and preferably between 300 and 1,000 and consisting of recurring units of formula (II),
- the wound suture material according to the present invention is essentially characterized in that it consists mainly of a composition based on methylidene malonate itself itself mainly consisting of monomer (s) and / or oligomer (s) of molecular weight less than or equal to 6000, preferably less than or equal to 3000.
- Such a composition has viscosity and bioadhesion (or bonding) properties allowing its use in the treatment of dermo-epidermal wounds, alone or in admixture with other biocompatible components.
- compositions based on methylidene malonate which can be used in the context of the invention are degradable by bioerosion, by releasing ethanol and glycolic acid which are generally considered to be non-toxic for the organism, glycolic acid even seems to act as a stimulator of cell growth.
- These compositions based on methylidene malonate can be easily prepared by the skilled person, optionally by simple mixing in an appropriate solvent of its constituents (monomeric, oligomeric, polymeric) prepared separately, and subsequent evaporation of the solvent.
- the methylidene malonate monomers can be prepared by following the process described in patent EP 0,283,346 corresponding to the patents
- the oligomers and polymers of methylidene malonate can be synthesized anionically or radically from the abovementioned monomers.
- compositions which are formed from a mixture of oligomer (s) and polymer (s)
- these compositions can also be obtained in a single step; the relative proportions of the constituents can be adjusted by varying the concentration of anionic or radical initiator in the polymerization medium.
- the physicochemical characteristics of the abovementioned methylidene malonate compositions can be easily adjusted by a person skilled in the art, in order to obtain a wound suturing material having the required bioadhesion and viscosity characteristics.
- the constituents of the wound suturing material according to the invention may represent up to 50% by weight of this material.
- These constituents will of course be chosen so as to form, with the compositions based on methylidene malonate mentioned above, intimate mixtures having the desired bio-adhesion and viscosity characteristics.
- these constituents will represent only about 1 to 20%, more preferably 1 to 10% by weight, relative to the total weight of the suture material.
- polycyanoacrylates preferably polyalkylcyanoacrylates
- Preferred additional constituents are, for example, polyethylene glycol, a hydrophilic additive belonging to the family of polyoxyalkylenes capable of thwarting the role of plasticizer within the mixture, or alternatively poly (lactide-co-glycolide), a biodegradable additive belonging to the family of polylactate-co-glycolates capable of allowing an improvement in the biodegradability of the mixture.
- these constituents will be present within the suture material in the form of mixtures with the compositions based on methylidene malonate mentioned above. It should be noted that, without departing from the scope of the present invention, these constituents may also be present within the suture material in the form of monomeric units in copolymers comprising methylidene malonate units of formula (II), as defined previously.
- methylidene malonate-based copolymers can be prepared by conventional polymerization techniques well known to those skilled in the art, among which mention may be made of anionic polymerization, radical polymerization or else the technique of coupling the precursor sequences of the copolymer, these sequences having previously been adequately functionalized at the end of the chain.
- the monomeric units forming the abovementioned constituents will be chosen from the constituent monomeric units of polyacrylates, polysaccharides, polyoxyalkylenes, polylactates and polylactate-co-glycolates.
- alkylcyanoacrylates alkyl methacrylates and itaconates.
- the copolymers based on methylidene malonate used in the context of the present invention will consist, for at least 50% of their monomeric units, by methylidene malonate units.
- copolymers may be random or have block or grafted structures.
- the suture material in accordance with the present invention may, where appropriate, comprise, among its constituents, biocompatible products capable of adjusting its viscosity, such as, for example, plasticizers, or even biocompatible products making it possible to improve adhesion, such as for example so-called "tackifying" resins.
- biocompatible products capable of adjusting its viscosity such as, for example, plasticizers, or even biocompatible products making it possible to improve adhesion, such as for example so-called "tackifying" resins.
- plasticizing agents which are suitable in the context of the present invention, there may be mentioned, for example, esters derived from adipic acid, azelaic acid, citric acid, oleic acid, stearic acid. , sebaccic acid; polyethylene glycol.
- tackifying resins which are suitable in the context of the present invention, mention may be made of modified polyterpene or terpene resins, hydrocarbon resins, mixtures of aromatic and aliphatic resins.
- the suture material in accordance with the present invention, can also comprise, among its constituents, one or more active ingredients chosen in particular from local anesthetics, such as lidocaine; bacteriostatic agents and antibiotic agents, such as, for example, streptomycin; analgesics, such as ketoprofen.
- local anesthetics such as lidocaine
- bacteriostatic agents and antibiotic agents such as, for example, streptomycin
- analgesics such as ketoprofen.
- the subject of the present invention is a method for treating epidermal, dermo-epidermal, hypo-dermo-epidermal wounds, characterized in that it consists in applying to the interior of said wound. a sufficient quantity of a wound suturing material as defined above, preheated if necessary to a temperature above its softening temperature.
- the aforementioned preheating temperature is range from 35 ° C to 47 ° C.
- the suture material according to the present invention will be packaged in a form allowing its application, such as for example inside a self-heating syringe.
- PMM 2.1.2 oligomer or polymer consisting of recurring monomer units corresponding to the formula
- PEG poly (ethylene glycol)
- PLGA poly (lactide-co-glycolide)
- molecular weight means the weight-average molar mass designated M w , expressed in g / mole of polystyrene equivalent (PS), and measured by the method of
- CPG Gel Permeation Chromatography
- glass transition temperature (Tg) was determined by differential enthalpy analysis with a scanning speed of 10 ° C per minute.
- compositions based on methylidene malonate formed from mixtures of oligomers and polymers were prepared by anionic polymerization (0.1N NaOH) in solvent medium (acetone) from the monomer, in accordance with the following procedure:
- Composition No. 2 consists for about 78% by weight of oligomers of molecular weight less than 3,100, and for about 22% by weight of polymers whose majority representative has a molecular weight of 13,000.
- Composition No. 5 is made up of approximately 78% by weight of oligomers of molecular weight less than 5,100 and of approximately 22% by weight of polymers whose majority representative has a molecular weight of approximately 18,000.
- a study carried out on flaps of human skin coming from surgical waste on abdominoplasties made it possible to confirm that all these compositions have all the qualities required, in particular in terms of bio-adhesion and viscosity, to be able to be used as suture material. , alone or in combination with other bio-compatible constituents, as defined above.
- composition No. 1 It has been observed that a small amount of composition is sufficient to obtain satisfactory tackiness when manual compression of the two edges of the wound is carried out after application of said composition. The best results have been obtained with composition No. 1.
- the glass transition temperature is less than 0 ° C., to prevent these compositions from solidifying too quickly before application inside the wound.
- this glass transition temperature will be between - 10 and - 35 ° C. and more preferably between - 20 ° C and - 30 ° C.
- compositions based on methylidene malonate formed from a mixture of oligomers and polymers and optionally incorporating one or more other constituents were prepared by mixing in an appropriate solvent. More specifically, the methylidene malonate oligomers, the methylidene malonate polymers and optionally an additional constituent were weighed in previously determined quantities, and dissolved in a common solvent (generally acetone) with magnetic stirring, then the solvent was evaporated using a rotary evaporator, and the mixture dried in a desiccator under primary vacuum.
- a common solvent generally acetone
- compositions 6 and 7 only consist of oligomers and polymers of methylidene malonate 2.1.2.
- compositions n ° 8 and 9 also comprise a hydrophilic additive of the PEG type of low molar mass which can be used as a plasticizer within the mixture.
- compositions 10 and 11 also contain a biodegradable additive of the PLGA type which can be used to modulate the bio-degradability of the mixture.
- the PLGA used has the following characteristics:
- Composition No. 11 also comprises a part consisting of methylidene malonate 2.1.2 monomers, this monomer having been added cold to a mixture in acetone consisting of the three other components.
- the compositions no. 12 and 13 also comprise an amphiphilic additive, itself based on methylidene malonate 2.1.2 which has good affinity with the other components and makes it possible to improve the behavior of the adhesive on the wound.
- This amphiphilic additive is a block copolymer having 250 ethylene oxide units and 43 MM 2.1.2 units prepared anionically by successive polymerization of ethylene oxide and then MM 2.1.2.
- Composition No. 14 further comprises a bio-degradable additive based on MM 2.1.2 which is a PMM 2.1.2 - P ⁇ CL copolymer which has good affinity with the mixture and a biodegradable sequence enabling the kinetics of overall degradability to be modulated. of said mixture.
- MM 2.1.2 which is a PMM 2.1.2 - P ⁇ CL copolymer which has good affinity with the mixture and a biodegradable sequence enabling the kinetics of overall degradability to be modulated. of said mixture.
- This additive is a block copolymer having a PMM 2.1.2 sequence of 5800 g / mol, and a P ⁇ CL block of 2000 g / mol which was prepared by chemical coupling between the two homopolymers, PMM 2.1.2 ⁇ -hydroxy functionalized and functionalized P ⁇ CL ⁇ -carboxy, in the presence of DCC in dichloromethane.
- composition No. 1 which has a glass transition temperature of -22 ° C., and in parallel against a reference system (suture by non-absorbable thread).
- Betadine disinfection for a second shave
- the temperature is taken in a control flask containing water.
- a sample of the composition tested is taken from the dish using a fine spatula of a chemist (3 mm wide and 1 mm thick) for application, f - a digital approximation of s 2 banks of the wound for
- each guinea pig is sutured using a Prolene Blue 4/0 monofilament equipped with a needle. P3 curve, 13 mm section.
- the method of suturing the incision is as follows:
- each guinea pig is returned to its cage, wakes up in less than 5 minutes after the operation, then is free to move.
- the guinea pigs are sacrificed by intraperitoneal injection of a solution of phenobarbital after eleven days for the "glue” group and after twelve days for the "suture" group.
- Two excision-biopsies, per guinea-pig, are carried out: a witness in healthy skin and one taking a global scar.
- the total duration of the operations was 1 hour between the first and the last guinea pig in each group.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/509,830 US6610078B1 (en) | 1999-02-09 | 2000-02-09 | Suture material for wounds based on methylidene malonate |
AU25543/00A AU767823B2 (en) | 1999-02-09 | 2000-02-09 | Suture material for wounds based on methylidene malonate |
AT00903761T ATE223739T1 (de) | 1999-02-09 | 2000-02-09 | Wundnahtmaterial auf der basis von methylidenmalonat |
DE60000437T DE60000437D1 (de) | 1999-02-09 | 2000-02-09 | Wundnahtmaterial auf der basis von methylidenmalonat |
CA002361628A CA2361628A1 (en) | 1999-02-09 | 2000-02-09 | Suture material for wounds based on methylidene malonate |
KR1020017010027A KR20010104341A (ko) | 1999-02-09 | 2000-02-09 | 메틸리덴 말로네이트를 기재로 한 상처 봉합 물질 |
PL00350244A PL350244A1 (en) | 1999-02-09 | 2000-02-09 | Suture material for wounds based on methylidene malonate |
DK00903761T DK1150723T3 (da) | 1999-02-09 | 2000-02-09 | Sammenføjningsmateriale til sår baseret på methylidenmalonat |
BR0008091-8A BR0008091A (pt) | 1999-02-09 | 2000-02-09 | Material de sutura de feridas, e, material |
JP2000598193A JP4863550B2 (ja) | 1999-02-09 | 2000-02-09 | マロン酸メチリデンベース傷縫合材料 |
EP00903761A EP1150723B1 (fr) | 1999-02-09 | 2000-02-09 | Materiau de suture de plaies a base de methylidene malonate |
SK1077-2001A SK10772001A3 (sk) | 1999-02-09 | 2000-02-09 | Materiál na zošitie rán na báze metylidénmalonátu |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR99/01485 | 1999-02-09 | ||
FR9901485A FR2789314B1 (fr) | 1999-02-09 | 1999-02-09 | Materiau de suture de plaies a base de methylidene malonate |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000047242A1 true WO2000047242A1 (fr) | 2000-08-17 |
Family
ID=9541764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2000/000305 WO2000047242A1 (fr) | 1999-02-09 | 2000-02-09 | Materiau de suture de plaies a base de methylidene malonate |
Country Status (22)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017021785A1 (en) | 2015-07-31 | 2017-02-09 | Afinitica Technologies, S.L. | Fast light curing cyanoacrylate compositions |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8795332B2 (en) | 2002-09-30 | 2014-08-05 | Ethicon, Inc. | Barbed sutures |
US6241747B1 (en) | 1993-05-03 | 2001-06-05 | Quill Medical, Inc. | Barbed Bodily tissue connector |
US5931855A (en) | 1997-05-21 | 1999-08-03 | Frank Hoffman | Surgical methods using one-way suture |
FR2774096B1 (fr) * | 1998-01-29 | 2000-04-07 | Virsol | Nouveaux copolymeres tensioactifs a base de methylidene malonate |
FR2812551B1 (fr) * | 2000-08-07 | 2003-03-28 | Virsol | Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire |
US7056331B2 (en) | 2001-06-29 | 2006-06-06 | Quill Medical, Inc. | Suture method |
US6848152B2 (en) | 2001-08-31 | 2005-02-01 | Quill Medical, Inc. | Method of forming barbs on a suture and apparatus for performing same |
US6773450B2 (en) | 2002-08-09 | 2004-08-10 | Quill Medical, Inc. | Suture anchor and method |
US20040088003A1 (en) | 2002-09-30 | 2004-05-06 | Leung Jeffrey C. | Barbed suture in combination with surgical needle |
US8100940B2 (en) | 2002-09-30 | 2012-01-24 | Quill Medical, Inc. | Barb configurations for barbed sutures |
US7624487B2 (en) | 2003-05-13 | 2009-12-01 | Quill Medical, Inc. | Apparatus and method for forming barbs on a suture |
RU2404717C2 (ru) | 2004-05-14 | 2010-11-27 | Квилл Медикал, Инк. | Способы и устройства для наложения швов |
JP2007100108A (ja) * | 2007-01-22 | 2007-04-19 | Dainippon Ink & Chem Inc | 硬化性樹脂組成物 |
US8915943B2 (en) | 2007-04-13 | 2014-12-23 | Ethicon, Inc. | Self-retaining systems for surgical procedures |
EP2197501B8 (en) | 2007-09-27 | 2012-10-03 | Ethicon, LLC | Self-retaining sutures including tissue retainers having improved strength |
US8916077B1 (en) | 2007-12-19 | 2014-12-23 | Ethicon, Inc. | Self-retaining sutures with retainers formed from molten material |
JP5518737B2 (ja) | 2007-12-19 | 2014-06-11 | エシコン・エルエルシー | 熱接触媒介リテーナを備えた留置縫合糸 |
US8118834B1 (en) | 2007-12-20 | 2012-02-21 | Angiotech Pharmaceuticals, Inc. | Composite self-retaining sutures and method |
WO2009097556A2 (en) | 2008-01-30 | 2009-08-06 | Angiotech Pharmaceuticals, Inc. | Appartaus and method for forming self-retaining sutures |
US8615856B1 (en) | 2008-01-30 | 2013-12-31 | Ethicon, Inc. | Apparatus and method for forming self-retaining sutures |
US9125647B2 (en) | 2008-02-21 | 2015-09-08 | Ethicon, Inc. | Method and apparatus for elevating retainers on self-retaining sutures |
US8216273B1 (en) | 2008-02-25 | 2012-07-10 | Ethicon, Inc. | Self-retainers with supporting structures on a suture |
US8641732B1 (en) | 2008-02-26 | 2014-02-04 | Ethicon, Inc. | Self-retaining suture with variable dimension filament and method |
BRPI0911132B8 (pt) | 2008-04-15 | 2021-06-22 | Angiotech Pharm Inc | sutura para ser usada em um procedimento aplicado ao tecido |
US8961560B2 (en) | 2008-05-16 | 2015-02-24 | Ethicon, Inc. | Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods |
BRPI0921810B8 (pt) | 2008-11-03 | 2021-06-22 | Angiotech Pharm Inc | montagem para inserir um comprimento de sutura no interior do corpo de um mamífero |
US8106234B2 (en) * | 2009-05-07 | 2012-01-31 | OptMed, Inc | Methylidene malonate process |
US8975435B2 (en) * | 2009-05-07 | 2015-03-10 | Optmed, Inc. | Methylidene malonate process |
KR101883143B1 (ko) | 2010-05-04 | 2018-07-31 | 에티컨, 엘엘씨 | 자가-유지형 봉합재를 생성하기 위한 레이저 커팅 시스템 및 방법 |
BR112012031606B1 (pt) | 2010-06-11 | 2020-11-10 | Ethicon Llc | distribuidor de sutura |
MX2013004513A (es) | 2010-10-20 | 2013-09-26 | Bioformix Inc | Síntesis de metilenmalonatos sustancialmente libres de impurezas. |
US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
US9279022B1 (en) * | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
AU2011323299B2 (en) | 2010-11-03 | 2016-06-30 | Ethicon Llc | Drug-eluting self-retaining sutures and methods relating thereto |
EP2637574B1 (en) | 2010-11-09 | 2016-10-26 | Ethicon, LLC | Emergency self-retaining sutures |
RU2659454C2 (ru) | 2011-03-23 | 2018-07-02 | ЭТИКОН ЭлЭлСи | Самоудерживающиеся нити с регулируемой петлей |
US20130172931A1 (en) | 2011-06-06 | 2013-07-04 | Jeffrey M. Gross | Methods and devices for soft palate tissue elevation procedures |
JP2014534969A (ja) | 2011-10-19 | 2014-12-25 | シラス・インコーポレイテッド | メチレンβ−ケトエステルモノマー、メチレンβ−ケトエステルモノマーを製造するための方法、これらから作られる重合可能な組成物および製品 |
JP6553505B2 (ja) | 2012-03-30 | 2019-07-31 | シラス・インコーポレイテッド | 複合材およびラミネート物品ならびにこれらを作製するための重合系 |
JP6188252B2 (ja) | 2012-03-30 | 2017-08-30 | シラス・インコーポレイテッド | 重合性組成物の活性化方法、重合系およびこれにより形成される製品 |
US9234107B2 (en) | 2012-03-30 | 2016-01-12 | Sirrus, Inc. | Ink coating formulations and polymerizable systems for producing the same |
WO2013181600A2 (en) | 2012-06-01 | 2013-12-05 | Bioformix Inc. | Optical material and articles formed therefrom |
WO2014078689A1 (en) | 2012-11-16 | 2014-05-22 | Bioformix Inc. | Plastics bonding systems and methods |
US10607910B2 (en) | 2012-11-30 | 2020-03-31 | Sirrus, Inc. | Composite compositions for electronics applications |
CN105008321A (zh) | 2013-01-11 | 2015-10-28 | 瑟拉斯公司 | 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法 |
US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
EP3310821B1 (en) * | 2015-06-19 | 2021-02-17 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
US11591425B2 (en) | 2017-06-02 | 2023-02-28 | Arkema France | Curable compositions and uses thereof |
WO2021014219A2 (en) | 2019-07-19 | 2021-01-28 | Arkema France | Curable compositions useful for obtaining non-sensitizing cured products |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996000760A1 (en) * | 1994-06-28 | 1996-01-11 | Tri-Point Medical Corporation | pH-MODIFIED BIOCOMPATIBLE MONOMER AND POLYMER COMPOSITIONS |
WO1996002278A1 (fr) * | 1994-07-18 | 1996-02-01 | Laboratoires Upsa | Immunonanoparticules revetues d'anticorps monoclonaux anti-beta-2 microglobuline |
DE19508049A1 (de) * | 1995-02-23 | 1996-09-12 | Schering Ag | Verwendung von Methylenmalondiesterderivaten zur Herstellung von Mikropartikel |
US5575997A (en) * | 1993-03-31 | 1996-11-19 | Tri-Point Medical Corporation | Biocompatible monomer and polymer compositions |
US5624669A (en) * | 1993-03-31 | 1997-04-29 | Tri-Point Medical Corporation | Method of hemostatic sealing of blood vessels and internal organs |
WO1998018455A1 (fr) * | 1996-10-25 | 1998-05-07 | Virsol | Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550172A (en) * | 1995-02-07 | 1996-08-27 | Ethicon, Inc. | Utilization of biocompatible adhesive/sealant materials for securing surgical devices |
-
1999
- 1999-02-09 FR FR9901485A patent/FR2789314B1/fr not_active Expired - Fee Related
-
2000
- 2000-02-08 TW TW089102064A patent/TW492883B/zh not_active IP Right Cessation
- 2000-02-09 ES ES00903761T patent/ES2183782T3/es not_active Expired - Lifetime
- 2000-02-09 AT AT00903761T patent/ATE223739T1/de not_active IP Right Cessation
- 2000-02-09 PL PL00350244A patent/PL350244A1/xx unknown
- 2000-02-09 WO PCT/FR2000/000305 patent/WO2000047242A1/fr active Search and Examination
- 2000-02-09 CZ CZ20012896A patent/CZ20012896A3/cs unknown
- 2000-02-09 RU RU2001124828/15A patent/RU2241494C2/ru not_active IP Right Cessation
- 2000-02-09 EP EP00903761A patent/EP1150723B1/fr not_active Expired - Lifetime
- 2000-02-09 DK DK00903761T patent/DK1150723T3/da active
- 2000-02-09 PT PT00903761T patent/PT1150723E/pt unknown
- 2000-02-09 BR BR0008091-8A patent/BR0008091A/pt not_active Application Discontinuation
- 2000-02-09 HU HU0200330A patent/HUP0200330A2/hu unknown
- 2000-02-09 AR ARP000100556A patent/AR022549A1/es unknown
- 2000-02-09 CN CNA2004100637016A patent/CN1559622A/zh active Pending
- 2000-02-09 KR KR1020017010027A patent/KR20010104341A/ko not_active Application Discontinuation
- 2000-02-09 SK SK1077-2001A patent/SK10772001A3/sk unknown
- 2000-02-09 CA CA002361628A patent/CA2361628A1/en not_active Abandoned
- 2000-02-09 AU AU25543/00A patent/AU767823B2/en not_active Ceased
- 2000-02-09 CN CN00803582A patent/CN1339974A/zh active Pending
- 2000-02-09 DE DE60000437T patent/DE60000437D1/de not_active Expired - Fee Related
- 2000-02-09 US US09/509,830 patent/US6610078B1/en not_active Expired - Lifetime
- 2000-02-09 JP JP2000598193A patent/JP4863550B2/ja not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5575997A (en) * | 1993-03-31 | 1996-11-19 | Tri-Point Medical Corporation | Biocompatible monomer and polymer compositions |
US5624669A (en) * | 1993-03-31 | 1997-04-29 | Tri-Point Medical Corporation | Method of hemostatic sealing of blood vessels and internal organs |
WO1996000760A1 (en) * | 1994-06-28 | 1996-01-11 | Tri-Point Medical Corporation | pH-MODIFIED BIOCOMPATIBLE MONOMER AND POLYMER COMPOSITIONS |
WO1996002278A1 (fr) * | 1994-07-18 | 1996-02-01 | Laboratoires Upsa | Immunonanoparticules revetues d'anticorps monoclonaux anti-beta-2 microglobuline |
DE19508049A1 (de) * | 1995-02-23 | 1996-09-12 | Schering Ag | Verwendung von Methylenmalondiesterderivaten zur Herstellung von Mikropartikel |
WO1998018455A1 (fr) * | 1996-10-25 | 1998-05-07 | Virsol | Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017021785A1 (en) | 2015-07-31 | 2017-02-09 | Afinitica Technologies, S.L. | Fast light curing cyanoacrylate compositions |
US10626310B2 (en) | 2015-07-31 | 2020-04-21 | Afinitica Technologies, S.L. | Fast light curing cyanoacrylate compositions |
Also Published As
Publication number | Publication date |
---|---|
CZ20012896A3 (cs) | 2002-01-16 |
DK1150723T3 (da) | 2003-01-20 |
SK10772001A3 (sk) | 2001-12-03 |
CN1339974A (zh) | 2002-03-13 |
FR2789314A1 (fr) | 2000-08-11 |
AU767823B2 (en) | 2003-11-27 |
JP2002536124A (ja) | 2002-10-29 |
FR2789314B1 (fr) | 2001-04-27 |
CA2361628A1 (en) | 2000-08-17 |
CN1559622A (zh) | 2005-01-05 |
US6610078B1 (en) | 2003-08-26 |
KR20010104341A (ko) | 2001-11-24 |
JP4863550B2 (ja) | 2012-01-25 |
PL350244A1 (en) | 2002-12-02 |
DE60000437D1 (de) | 2002-10-17 |
BR0008091A (pt) | 2001-11-13 |
TW492883B (en) | 2002-07-01 |
EP1150723B1 (fr) | 2002-09-11 |
PT1150723E (pt) | 2003-01-31 |
HUP0200330A2 (en) | 2002-06-29 |
EP1150723A1 (fr) | 2001-11-07 |
RU2241494C2 (ru) | 2004-12-10 |
AR022549A1 (es) | 2002-09-04 |
ATE223739T1 (de) | 2002-09-15 |
AU2554300A (en) | 2000-08-29 |
ES2183782T3 (es) | 2003-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1150723B1 (fr) | Materiau de suture de plaies a base de methylidene malonate | |
EP0664132B1 (fr) | Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé | |
Jenkins et al. | Integrating mussel chemistry into a bio-based polymer to create degradable adhesives | |
EP0863933B1 (fr) | Nouveaux hydrogels a base de copolymeres trisequences, leur preparation et leur application | |
EP0862468B2 (fr) | Composition adhesive a base de polyaldehyde macromoleculaire et procede de reticulation de collagene | |
AU2009296249B2 (en) | Bioadhesive constructs | |
EP1115434B1 (fr) | Mousse proteique adhesive a usage chirurgical et/ou therapeutique | |
EP1307245B1 (fr) | Forme pharmaceutique comprenant un facteur de regulation cellulaire et/ou un promoteur de proliferation cellulaire | |
JP2007217699A (ja) | 生体適合性架橋ポリマー | |
CH667874A5 (fr) | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. | |
FR2889449A1 (fr) | Preparations implantables | |
JPH11263830A (ja) | 炭酸トリメチレンと光学不活性ラクチドとからなる新規コポリマ― | |
EP1940877A1 (fr) | Polymères biodégradables modifiés, leur préparation et leur usage pour la fabrication de biomatériaux et de pansements | |
Zhu et al. | A mussel-inspired wet-adhesion hydrogel with hemostasis and local anti-inflammation for managing the development of acute wounds | |
EP2148686A2 (fr) | Nouveau principe actif dans la cicatrisation et son utilisation | |
JP2011074075A (ja) | 多機構外科用組成物 | |
JP4709479B2 (ja) | 高分子ミセルを有効成分とする組織接着剤 | |
NL2028827B1 (en) | Bio-adhesive | |
FR2560048A1 (fr) | Matiere pour elements de jonction de parties molles de l'organisme et de visceres. | |
CN115814173B (zh) | 自粘性可吸收生物补片及其制备方法和应用 | |
US20230390191A1 (en) | Self-regulating bioadhesives for wet substrates | |
WO2009050361A1 (fr) | Gel de polyacrylamide naturellement resorbable, procede d'obtention et utilisations | |
CA2620633A1 (fr) | Polymeres biodegradables modifies, leur preparation et leur usage pour la fabrication de biomateriaux et de pansements | |
KR20210124767A (ko) | 실크 피브로인을 포함하는 광경화성 하이드로겔 지혈제 및 이의 제조 방법 | |
FR2909285A1 (fr) | "utilisation d'un gel anti-adhesif et anti fibrotique" |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 00803582.2 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09509830 Country of ref document: US |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2000903761 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10772001 Country of ref document: SK |
|
WWE | Wipo information: entry into national phase |
Ref document number: 25543/00 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2000 598193 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2001/008028 Country of ref document: MX Ref document number: 1020017010027 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: 2361628 Country of ref document: CA Ref document number: 2361628 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV2001-2896 Country of ref document: CZ |
|
WWP | Wipo information: published in national office |
Ref document number: 2000903761 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1020017010027 Country of ref document: KR |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: PV2001-2896 Country of ref document: CZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 2000903761 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 25543/00 Country of ref document: AU |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1020017010027 Country of ref document: KR |
|
DPE2 | Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101) |